Aliases for JAG1 Gene
External Ids for JAG1 Gene
Previous HGNC Symbols for JAG1 Gene
Previous GeneCards Identifiers for JAG1 Gene
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for JAG1 Gene
JAG1 (Jagged 1) is a Protein Coding gene. Diseases associated with JAG1 include alagille syndrome and jag1-related alagille syndrome. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include calcium ion binding and growth factor activity. An important paralog of this gene is NOTCH2.
UniProtKB/Swiss-Prot for JAG1 Gene
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).