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Aliases for JADE3 Gene

Aliases for JADE3 Gene

  • Jade Family PHD Finger 3 2 3
  • PHD Finger Protein 16 2 3 4
  • PHF16 3 4 6
  • Jade Family PHD Finger Protein 3 3 4
  • KIAA0215 4 6
  • Protein Jade-3 3
  • JADE-3 3

External Ids for JADE3 Gene

Previous HGNC Symbols for JADE3 Gene

  • PHF16

Previous GeneCards Identifiers for JADE3 Gene

  • GC0XP046773

Summaries for JADE3 Gene

Entrez Gene Summary for JADE3 Gene

  • This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

GeneCards Summary for JADE3 Gene

JADE3 (Jade Family PHD Finger 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for JADE3 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.

Gene Wiki entry for JADE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JADE3 Gene

Genomics for JADE3 Gene

Genomic Location for JADE3 Gene

Start:
46,912,276 bp from pter
End:
47,061,242 bp from pter
Size:
148,967 bases
Orientation:
Plus strand

Genomic View for JADE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JADE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JADE3 Gene

No data available for Regulatory Elements for JADE3 Gene

Proteins for JADE3 Gene

  • Protein details for JADE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92613-JADE3_HUMAN
    Recommended name:
    Protein Jade-3
    Protein Accession:
    Q92613
    Secondary Accessions:
    • Q6IE79

    Protein attributes for JADE3 Gene

    Size:
    823 amino acids
    Molecular mass:
    93808 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.
    SequenceCaution:
    • Sequence=BAA13205.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for JADE3 Gene

Proteomics data for JADE3 Gene at MOPED

Post-translational modifications for JADE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JADE3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for JADE3 Gene

Domains for JADE3 Gene

Gene Families for JADE3 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Graphical View of Domain Structure for InterPro Entry

Q92613

UniProtKB/Swiss-Prot:

JADE3_HUMAN :
  • Q92613
Family:
  • Belongs to the JADE family.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with JADE3: view

No data available for Suggested Antigen Peptide Sequences for JADE3 Gene

Function for JADE3 Gene

Molecular function for JADE3 Gene

UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.
UniProtKB/Swiss-Prot Induction: By estradiol in estrogen-responsive breast cancer cells.

Gene Ontology (GO) - Molecular Function for JADE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with JADE3: view

Phenotypes for JADE3 Gene

MGI mutant phenotypes for JADE3:
inferred from 1 alleles
GenomeRNAi human phenotypes for JADE3:
genes like me logo Genes that share phenotypes with JADE3: view

Animal Model Products

CRISPR Products

miRNA for JADE3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JADE3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for JADE3 Gene

Localization for JADE3 Gene

Gene Ontology (GO) - Cellular Components for JADE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with JADE3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for JADE3 Gene

Pathways for JADE3 Gene

genes like me logo Genes that share pathways with JADE3: view

Pathways by source for JADE3 Gene

Interacting Proteins for JADE3 Gene

Selected Interacting proteins: Q92613-JADE3_HUMAN for JADE3 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for JADE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043966 histone H3 acetylation IDA 16387653
GO:0043981 histone H4-K5 acetylation IDA 16387653
GO:0043982 histone H4-K8 acetylation IDA 16387653
GO:0043983 histone H4-K12 acetylation IDA 16387653
GO:0043984 NOT histone H4-K16 acetylation IDA 16387653
genes like me logo Genes that share ontologies with JADE3: view

Transcripts for JADE3 Gene

mRNA/cDNA for JADE3 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JADE3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for JADE3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JADE3 Gene

No ASD Table

Relevant External Links for JADE3 Gene

GeneLoc Exon Structure for
JADE3
ECgene alternative splicing isoforms for
JADE3

Expression for JADE3 Gene

mRNA expression in normal human tissues for JADE3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for JADE3 Gene

mRNA Expression by UniProt/SwissProt for JADE3 Gene

Q92613-JADE3_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in placenta and uterus.
genes like me logo Genes that share expressions with JADE3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for JADE3 Gene

Orthologs for JADE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for JADE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JADE3 36
  • 99 (a)
OneToOne
PHF16 35
  • 99.04 (n)
  • 98.57 (a)
cow
(Bos Taurus)
Mammalia JADE3 36
  • 84 (a)
OneToOne
PHF16 35
  • 88.01 (n)
  • 83.96 (a)
dog
(Canis familiaris)
Mammalia JADE3 36
  • 88 (a)
OneToOne
PHF16 35
  • 90.64 (n)
  • 89.31 (a)
mouse
(Mus musculus)
Mammalia Jade3 35
  • 84.89 (n)
  • 82.02 (a)
Phf16 16
Phf16 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JADE3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JADE3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jade3 35
  • 85.34 (n)
  • 82.99 (a)
chicken
(Gallus gallus)
Aves JADE3 36
  • 74 (a)
OneToOne
PHF16 35
  • 75.05 (n)
  • 74.48 (a)
lizard
(Anolis carolinensis)
Reptilia JADE3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jade3 35
  • 67.64 (n)
  • 67.72 (a)
Str.566 35
zebrafish
(Danio rerio)
Actinopterygii jade3 35
  • 64.38 (n)
  • 63.19 (a)
jade3 35
jade3 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rno 36
  • 10 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.659 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for JADE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JADE3 Gene

ENSEMBL:
Gene Tree for JADE3 (if available)
TreeFam:
Gene Tree for JADE3 (if available)

Paralogs for JADE3 Gene

Paralogs for JADE3 Gene

Selected SIMAP similar genes for JADE3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JADE3: view

Variants for JADE3 Gene

Sequence variations from dbSNP and Humsavar for JADE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6725 -- 47,061,200(+) ATGTC(A/C)CCTTT utr-variant-3-prime
rs962473 -- 47,026,494(-) AAAAA(A/C)CCTTG intron-variant
rs996918 -- 46,957,406(+) ATTAT(A/G)TGTCA intron-variant
rs1154782 -- 46,994,624(-) CCCCA(A/T)CAAGA intron-variant
rs1984390 -- 47,033,076(-) GTGAA(A/T)GAATC intron-variant

Relevant External Links for JADE3 Gene

HapMap Linkage Disequilibrium report
JADE3
Locus Specific Mutation Databases (LSDB)
PHF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JADE3 Gene

Disorders for JADE3 Gene

No disorders were found for JADE3 Gene.

No data available for UniProtKB/Swiss-Prot for JADE3 Gene

Publications for JADE3 Gene

  1. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Identification of human estrogen-inducible transcripts that potentially mediate the apoptotic response in breast cancer. (PMID: 10775800) Szelei J. … Sonnenschein C. (J. Steroid Biochem. Mol. Biol. 2000) 3 4
  5. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 2 3

Products for JADE3 Gene

Sources for JADE3 Gene

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