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Aliases for JADE2 Gene

Aliases for JADE2 Gene

  • Jade Family PHD Finger 2 2 3
  • PHD Finger Protein 15 2 3 4
  • PHF15 3 4 6
  • Jade Family PHD Finger Protein 2 3 4
  • KIAA0239 4 6
  • Protein Jade-2 3
  • JADE-2 3

External Ids for JADE2 Gene

Previous Symbols for JADE2 Gene

  • PHF15

Summaries for JADE2 Gene

GeneCards Summary for JADE2 Gene

JADE2 (Jade Family PHD Finger 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for JADE2 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JADE2 Gene

Genomics for JADE2 Gene

Genomic Location for JADE2 Gene

Start:
134,524,312 bp from pter
End:
134,583,230 bp from pter
Size:
58,919 bases
Orientation:
Plus strand

Genomic View for JADE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JADE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JADE2 Gene

No data available for Regulatory Elements for JADE2 Gene

Proteins for JADE2 Gene

  • Protein details for JADE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQC1-JADE2_HUMAN
    Recommended name:
    Protein Jade-2
    Protein Accession:
    Q9NQC1
    Secondary Accessions:
    • D3DQA3
    • Q6IE80
    • Q8TEK0
    • Q92513
    • Q96GQ6

    Protein attributes for JADE2 Gene

    Size:
    790 amino acids
    Molecular mass:
    87466 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.
    SequenceCaution:
    • Sequence=BAA13245.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84949.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305}; Sequence=CAB94935.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JADE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JADE2 Gene

Proteomics data for JADE2 Gene at MOPED

Post-translational modifications for JADE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JADE2 Gene

No data available for DME Specific Peptides for JADE2 Gene

Domains for JADE2 Gene

Gene Families for JADE2 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

JADE2_HUMAN
Family:
  • Belongs to the JADE family.:
    • Q9NQC1
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q9NQC1
genes like me logo Genes that share domains with JADE2: view

Function for JADE2 Gene

Molecular function for JADE2 Gene

UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.

Gene Ontology (GO) - Molecular Function for JADE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with JADE2: view
genes like me logo Genes that share phenotypes with JADE2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for JADE2 Gene

Localization for JADE2 Gene

Gene Ontology (GO) - Cellular Components for JADE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with JADE2: view

Pathways for JADE2 Gene

genes like me logo Genes that share pathways with JADE2: view

Pathways by source for JADE2 Gene

Gene Ontology (GO) - Biological Process for JADE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043966 histone H3 acetylation IDA 16387653
GO:0043981 histone H4-K5 acetylation IDA 16387653
GO:0043982 histone H4-K8 acetylation IDA 16387653
GO:0043983 histone H4-K12 acetylation IDA 16387653
GO:0043984 NOT histone H4-K16 acetylation IDA 16387653
genes like me logo Genes that share ontologies with JADE2: view

Transcripts for JADE2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for JADE2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - -
SP7:
SP8: -
SP9: -
SP10: - -
SP11:
SP12:

ExUns: 16b ^ 17
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for JADE2 Gene

GeneLoc Exon Structure for
JADE2
ECgene alternative splicing isoforms for
JADE2

Expression for JADE2 Gene

mRNA expression in normal human tissues for JADE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JADE2 Gene

genes like me logo Genes that share expressions with JADE2: view

Orthologs for JADE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JADE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JADE2 37
  • 100 (a)
OneToOne
PHF15 36
  • 99.41 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia JADE2 37
  • 90 (a)
OneToOne
PHF15 36
  • 91.67 (n)
  • 95.41 (a)
dog
(Canis familiaris)
Mammalia JADE2 37
  • 87 (a)
OneToOne
PHF15 36
  • 90.48 (n)
  • 94.49 (a)
mouse
(Mus musculus)
Mammalia Jade2 36
  • 87.52 (n)
  • 91.46 (a)
Phf15 16
Phf15 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JADE2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JADE2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jade2 36
  • 87.01 (n)
  • 90.83 (a)
chicken
(Gallus gallus)
Aves JADE2 37
  • 67 (a)
OneToOne
PHF15 36
  • 73.29 (n)
  • 75.19 (a)
lizard
(Anolis carolinensis)
Reptilia JADE2 37
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii JADE2 37
  • 55 (a)
OneToOne
phf15 36
  • 71.76 (n)
  • 69.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta rno 37
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for JADE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JADE2 Gene

ENSEMBL:
Gene Tree for JADE2 (if available)
TreeFam:
Gene Tree for JADE2 (if available)

Paralogs for JADE2 Gene

Paralogs for JADE2 Gene

Selected SIMAP similar genes for JADE2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with JADE2: view

Variants for JADE2 Gene

Sequence variations from dbSNP and Humsavar for JADE2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs167900 -- 134,524,302(+) GCCCG(A/C)GGCTC upstream-variant-2KB
rs179278 -- 134,542,892(+) catgc(A/C/G/T)gggct intron-variant
rs191294 -- 134,525,235(+) GAGCA(A/G)AAAGT upstream-variant-2KB, intron-variant
rs329115 -- 134,523,028(+) CTTTC(C/T)GAAAA upstream-variant-2KB
rs329116 -- 134,523,705(+) TTTGA(A/G)CTCAT upstream-variant-2KB

Relevant External Links for JADE2 Gene

HapMap Linkage Disequilibrium report
JADE2

No data available for Structural Variations from Database of Genomic Variants (DGV) for JADE2 Gene

Disorders for JADE2 Gene

No disorders were found for JADE2 Gene.

No data available for UniProtKB/Swiss-Prot for JADE2 Gene

Publications for JADE2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4
  5. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. (PMID: 14612400) Tzouanacou E. … Wilson V. (Mol. Cell. Biol. 2003) 3 4

Products for JADE2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate JADE2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for JADE2
    • Block miRNA regulation of JADE2 using miScript Target Protectors

    Sources for JADE2 Gene

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