Aliases for JADE1 Gene
External Ids for JADE1 Gene
Previous HGNC Symbols for JADE1 Gene
Previous GeneCards Identifiers for JADE1 Gene
GeneCards Summary for JADE1 Gene
JADE1 (Jade Family PHD Finger 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription coactivator activity. An important paralog of this gene is JADE2.
UniProtKB/Swiss-Prot for JADE1 Gene
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.