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JADE1 Gene

protein-coding   GIFtS: 48
GCID: GC04P129731

Jade Family PHD Finger 1

(Previous name: PHD finger protein 17)
(Previous symbol: PHF17)
  Search for JADE1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jade Family PHD Finger 11 2     Gene For Apoptosis And Differentiation In Epithelia2
PHF171 2 3 5     PHD Protein Jade-12
PHD Finger Protein 171 2 3     Protein Jade-12
Jade Family PHD Finger Protein 12 3     KIAA18073

External Ids:    HGNC: 300271   Entrez Gene: 799602   Ensembl: ENSG000000776847   OMIM: 6105145   UniProtKB: Q6IE813   

Export aliases for JADE1 gene to outside databases

Previous GC identifer: GC04P130189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JADE1 Gene:
JADE1 (jade family PHD finger 1) is a protein-coding gene. An important paralog of this gene is JADE2.

UniProtKB/Swiss-Prot: JADE1_HUMAN, Q6IE81
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional
coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a
renal tumor suppressor

Gene Wiki entry for JADE1 (PHF17) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for JADE1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJADE1 promoter sequence
   Search Chromatin IP Primers for JADE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JADE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27   Ensembl cytogenetic band:  4q28.2   HGNC cytogenetic band: 4q26-q27

JADE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JADE1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P129731:  view genomic region     (about GC identifiers)

Start:
129,730,779 bp from pter      End:
129,796,379 bp from pter
Size:
65,601 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: JADE1_HUMAN, Q6IE81 (See protein sequence)
Recommended Name: Protein Jade-1  
Size: 842 amino acids; 95533 Da
Subunit: Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1,
JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5
Sequence caution: Sequence=BAB15371.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC11335.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DNY0 D3DNY1 Q4W5D5 Q6ZSL7 Q8NC41 Q96JL8 Q96SQ1 Q9H692
Alternative splicing: 3 isoforms:  Q6IE81-1   Q6IE81-2   Q6IE81-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JADE1: NX_Q6IE81

Explore proteomics data for JADE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JADE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001274366.1  NP_001274368.1  NP_001274369.1  NP_001274370.1  NP_001274371.1  NP_001274372.1  NP_079176.2  NP_955352.1  

    ENSEMBL proteins: 
     ENSP00000423737   ENSP00000388015   ENSP00000426590   ENSP00000425730   ENSP00000422445  
     ENSP00000426920   ENSP00000421265   ENSP00000421778   ENSP00000404211   ENSP00000424280  
     ENSP00000425535   ENSP00000226319  
    Reactome Protein details: Q6IE81

    JADE1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019542 Enhancer_polycomb-like_N

    Graphical View of Domain Structure for InterPro Entry Q6IE81

    ProtoNet protein and cluster: Q6IE81

    UniProtKB/Swiss-Prot: JADE1_HUMAN, Q6IE81
    Domain: The 2 PHD-type zinc fingers are required for transcriptional activity
    Similarity: Belongs to the JADE family
    Similarity: Contains 2 PHD-type zinc fingers


    JADE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JADE1_HUMAN, Q6IE81
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional
    coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a
    renal tumor suppressor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IDA--
    GO:0005515protein binding IPI12169691
    GO:0008270zinc ion binding IEA--
         
    JADE1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for JADE1:
     Decreased viability with pacli  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Phf17):
     mortality/aging 

    JADE1 for phenotypes           About GeneDecksing

    Animal Models:
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    miRTarBase miRNAs that target JADE1:
    hsa-mir-124-3p (MIRT022313), hsa-mir-155-5p (MIRT001806), hsa-mir-21-5p (MIRT030770), hsa-mir-192-5p (MIRT026279), hsa-mir-324-3p (MIRT042863), hsa-mir-342-5p (MIRT038204), hsa-mir-145-5p (MIRT021530)

    Block miRNA regulation of human, mouse, rat JADE1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JADE1_HUMAN, Q6IE81: Cytoplasm. Nucleus

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA16387653
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12169691
    GO:0005739mitochondrion ----

    JADE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JADE1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for JADE1
        HATs acetylate histones



    JADE1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JADE1
    Interactions:

        Search GeneGlobe Interaction Network for JADE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for JADE1 (Q6IE812, 3 ENSP000002263194) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276472 MINT-2876576 I2D: score=4 STRING: ENSP00000381045
    SMN1Q166372, 3MINT-8271388 I2D: score=2 
    SMN2Q166372, 3MINT-8271388 I2D: score=2 
    HMOX2P305192, 3MINT-8258379 I2D: score=2 
    PFDN1O609252, 3MINT-8265974 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006915apoptotic process NAS12169691
    GO:0006950response to stress NAS12169691
    GO:0030308negative regulation of cell growth NAS12169691
    GO:0043966histone H3 acetylation IDA16387653

    JADE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JADE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for JADE1 gene (8 alternative transcripts): 
    NM_001287437.1  NM_001287439.1  NM_001287440.1  NM_001287441.1  NM_001287442.1  NM_001287443.1  NM_024900.4  NM_199320.3  

    Unigene Cluster for JADE1:

    PHD finger protein 17
    Hs.12420  [show with all ESTs]
    Unigene Representative Sequence: NM_199320
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511647 ENST00000452328 ENST00000504089 ENST00000512960 ENST00000503785
    ENST00000514740 ENST00000510308 ENST00000511925 ENST00000413543(uc003igj.3 uc003igm.3)
    ENST00000507833 ENST00000508997 ENST00000226319(uc003igk.3 uc003igl.3 uc011cgy.2)

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      QuantiFast Probe-based Assays in human, mouse, rat JADE1

    Additional mRNA sequence: 

    AB058710.1 AF520952.1 AK026132.1 AK027620.1 AK074986.1 AK127326.1 AK297357.1 AK304235.1 
    AK304815.1 BC032376.1 

    14 DOTS entries:

    DT.413933  DT.312111  DT.108704  DT.97810799  DT.95162900  DT.97829487  DT.100775334  DT.100837227 
    DT.121272906  DT.100774543  DT.121272886  DT.92422807  DT.95266680  DT.97829486 

    Selected AceView cDNA sequences (see all 272):

    AI089485 CA447486 F13175 BQ219053 CB114988 BU738962 AL541766 AA463295 
    BG150179 AI682446 BF438294 AW269233 BX107708 BP362166 BF988896 BE465864 
    AI361192 BQ008165 AK127326 CA418958 BQ017363 BQ576145 AI658994 BI964148 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for JADE1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
    SP1:              -     -     -     -     -     -     -                                   -                                                     -     -         
    SP2:                                                                                                                                            -     -         
    SP3:              -     -     -     -     -     -     -                                                                                                         
    SP4:                                                  -                                                                                                         
    SP5:                                -     -     -     -                                                                                                         

    ExUns: 14a · 14b · 14c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for JADE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JADE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    JADE1 Expression
    About this image

    JADE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JADE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12420

    UniProtKB/Swiss-Prot: JADE1_HUMAN, Q6IE81
    Tissue specificity: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level).
    Down-regulated in renal cancer cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JADE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JADE1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf175
    Jade11
    PHD finger protein 175
    jade family PHD finger 11
    90.3(n)1
    93.15(a)1
      3 (19.88 cM)5
    2694241  NM_001130185.11  NP_001123657.11 
     415557345 
    chicken
    (Gallus gallus)
    Aves PHF171 PHD finger protein 17 77.18(n)
    81.41(a)
      422502  XM_004941013.1  XP_004941070.1 
    lizard
    (Anolis carolinensis)
    Reptilia JADE16
    jade family PHD finger 1
    77(a)
    1 ↔ 1
    5(136004214-136073986)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193172 Xenopus laevis transcribed sequence with weak similarity more 76.19(n)    BQ384563.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi11a042 wufi11a04 77.68(n)   327437  BC046874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rno6
    rhinoceros
    10(a)
    1 → many
    3L(187207-199762)


    ENSEMBL Gene Tree for JADE1 (if available)
    TreeFam Gene Tree for JADE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JADE1 gene
    JADE22  PHF142  JADE32  BRD12  BRPF12  MLLT62  MLLT102  BRPF32  
    5 SIMAP similar genes for JADE1 using alignment to 8 protein entries:     JADE1_HUMAN (see all proteins):
    JADE3    AF10    JADE2    PHF15    MLL/AF10 fusion

    JADE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JADE1 (see all 1317)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs131429641,2
    C,F,H--129729064(+) cttaaC/Gaaccc 2 -- us2k122Minor allele frequency- G:0.08NS EA NA WA 2640
    rs1128569191,2
    C--129729147(+) ATCCC-/AACAGG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1814111461,2
    --129729225(+) TTCTAA/CAGAGA 2 -- us2k10--------
    rs100089271,2
    C,F,H--129729239(+) TGTGCA/GAGGTG 2 -- us2k123Minor allele frequency- G:0.26NS EA NA WA CSA 2341
    rs1426102311,2
    --129729273(+) AGTGCA/CATACT 2 -- us2k10--------
    rs131437711,2
    C,F,H--129729412(+) ATATAT/CAGTAC 2 -- us2k120Minor allele frequency- C:0.46NS EA NA WA 2346
    rs1866032611,2
    --129729507(+) TAACGG/TTCTGG 2 -- us2k10--------
    rs1919717831,2
    --129729555(+) ATTACA/GTGAAA 2 -- us2k10--------
    rs1433830671,2
    C--129729604(+) ACATAC/TGCCTT 2 -- us2k10--------
    rs1483864321,2
    --129729652(+) GTTCCC/TATTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for JADE1 (129730779 - 129796379 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for JADE1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JADE1
    DNA2.0 Custom Variant and Variant Library Synthesis for JADE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610514    OMIM disorders: --


    JADE1 for disorders           About GeneDecksing


    Export disorders for JADE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JADE1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with JADE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. (PubMed id 12169691)1, 2, 3, 9 Zhou M.I.... Cohen H.T. (J. Biol. Chem. 2002)
    2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    4. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. (PubMed id 16046545)1, 2 Zhou M.I....Cohen H.T. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. (PubMed id 15502158)1, 2 Panchenko M.V.... Cohen H.T. (J. Biol. Chem. 2004)
    9. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. (PubMed id 14612400)1, 2 Tzouanacou E.... Wilson V. (Mol. Cell. Biol. 2003)
    10. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. (PubMed id 18806787)1, 9 Chitalia V.C....Cohen H.T. (Nat. Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79960 HGNC: 30027 AceView: PHF17 Ensembl:ENSG00000077684 euGenes: HUgn79960
    ECgene: JADE1 H-InvDB: JADE1

    (According to HUGE)
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    HUGE: KIAA1807

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JADE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JADE1 gene:
    Search GeneIP for patents involving JADE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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