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Aliases for JADE1 Gene

Aliases for JADE1 Gene

  • Jade Family PHD Finger 1 2 3
  • PHD Finger Protein 17 2 3 4
  • Jade Family PHD Finger Protein 1 3 4
  • PHF17 3 4
  • Gene For Apoptosis And Differentiation In Epithelia 3
  • PHD Protein Jade-1 3
  • KIAA1807 4

External Ids for JADE1 Gene

Previous HGNC Symbols for JADE1 Gene

  • PHF17

Previous GeneCards Identifiers for JADE1 Gene

  • GC04P130189
  • GC04P129731

Summaries for JADE1 Gene

GeneCards Summary for JADE1 Gene

JADE1 (Jade Family PHD Finger 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include RNA polymerase II transcription coactivator activity. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for JADE1 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.

Gene Wiki entry for JADE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JADE1 Gene

Genomics for JADE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for JADE1 Gene

Chromosome:
4
Start:
128,809,623 bp from pter
End:
128,875,224 bp from pter
Size:
65,602 bases
Orientation:
Plus strand

Genomic View for JADE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JADE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JADE1 Gene

No data available for Regulatory Elements for JADE1 Gene

Proteins for JADE1 Gene

  • Protein details for JADE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IE81-JADE1_HUMAN
    Recommended name:
    Protein Jade-1
    Protein Accession:
    Q6IE81
    Secondary Accessions:
    • D3DNY0
    • D3DNY1
    • Q4W5D5
    • Q6ZSL7
    • Q8NC41
    • Q96JL8
    • Q96SQ1
    • Q9H692

    Protein attributes for JADE1 Gene

    Size:
    842 amino acids
    Molecular mass:
    95533 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5.
    SequenceCaution:
    • Sequence=BAB15371.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11335.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JADE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JADE1 Gene

Proteomics data for JADE1 Gene at MOPED

Post-translational modifications for JADE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JADE1 Gene

Domains & Families for JADE1 Gene

Gene Families for JADE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IE81

UniProtKB/Swiss-Prot:

JADE1_HUMAN :
  • The 2 PHD-type zinc fingers are required for transcriptional activity
  • Belongs to the JADE family.
  • Contains 2 PHD-type zinc fingers.
Domain:
  • The 2 PHD-type zinc fingers are required for transcriptional activity
Family:
  • Belongs to the JADE family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with JADE1: view

Function for JADE1 Gene

Molecular function for JADE1 Gene

UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.

Gene Ontology (GO) - Molecular Function for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity IDA 23001567
GO:0005515 protein binding IPI 12169691
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with JADE1: view

Phenotypes for JADE1 Gene

genes like me logo Genes that share phenotypes with JADE1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for JADE1 Gene

Localization for JADE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JADE1 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus IDA 12169691
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12169691
GO:0005829 cytosol IDA 24739512
genes like me logo Genes that share ontologies with JADE1: view

No data available for Subcellular locations from COMPARTMENTS for JADE1 Gene

Pathways & Interactions for JADE1 Gene

genes like me logo Genes that share pathways with JADE1: view

Pathways by source for JADE1 Gene

Gene Ontology (GO) - Biological Process for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process NAS 12169691
GO:0006950 response to stress NAS 12169691
GO:0030308 negative regulation of cell growth NAS 12169691
genes like me logo Genes that share ontologies with JADE1: view

No data available for SIGNOR curated interactions for JADE1 Gene

Drugs & Compounds for JADE1 Gene

No Compound Related Data Available

Transcripts for JADE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for JADE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: - - - - - -
SP10:

ExUns: 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for JADE1 Gene

GeneLoc Exon Structure for
JADE1
ECgene alternative splicing isoforms for
JADE1

Expression for JADE1 Gene

mRNA expression in normal human tissues for JADE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JADE1 Gene

This gene is overexpressed in Urine (28.5), Monocytes (15.1), and Retina (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JADE1 Gene



mRNA Expression by UniProt/SwissProt for JADE1 Gene

Q6IE81-JADE1_HUMAN
Tissue specificity: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
genes like me logo Genes that share expression patterns with JADE1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for JADE1 Gene

Orthologs for JADE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for JADE1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PHF17 35
  • 91.45 (n)
  • 95.61 (a)
JADE1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jade1 35
  • 90.3 (n)
  • 93.15 (a)
Phf17 16
Phf17 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PHF17 35
  • 99.68 (n)
  • 100 (a)
PHF17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jade1 35
  • 90.69 (n)
  • 94.32 (a)
cow
(Bos Taurus)
Mammalia JADE1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JADE1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHF17 35
  • 77.18 (n)
  • 81.41 (a)
JADE1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JADE1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jade1 35
  • 67.28 (n)
  • 70.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19317 35
zebrafish
(Danio rerio)
Actinopterygii jade1 35
  • 60.46 (n)
  • 58.37 (a)
wufi11a04 35
jade1 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rno 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for JADE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JADE1 Gene

ENSEMBL:
Gene Tree for JADE1 (if available)
TreeFam:
Gene Tree for JADE1 (if available)

Paralogs for JADE1 Gene

Paralogs for JADE1 Gene

genes like me logo Genes that share paralogs with JADE1: view

Variants for JADE1 Gene

Sequence variations from dbSNP and Humsavar for JADE1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_053777 -

Variation tolerance for JADE1 Gene

Residual Variation Intolerance Score: 9.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JADE1 Gene

HapMap Linkage Disequilibrium report
JADE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JADE1 Gene

Disorders for JADE1 Gene

Relevant External Links for JADE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JADE1
genes like me logo Genes that share disorders with JADE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JADE1 Gene

Publications for JADE1 Gene

  1. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. (PMID: 12169691) Zhou M.I. … Cohen H.T. (J. Biol. Chem. 2002) 2 23 67
  2. Role of the VHL (von Hippel-Lindau) gene in renal cancer: a multifunctional tumour suppressor. (PMID: 18481984) Nyhan M.J. … McKenna S.L. (Biochem. Soc. Trans. 2008) 23 67
  3. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. (PMID: 18684714) Foy R.L. … Panchenko M.V. (J. Biol. Chem. 2008) 23 67
  4. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. (PMID: 18806787) Chitalia V.C. … Cohen H.T. (Nat. Cell Biol. 2008) 23 67
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 67

Products for JADE1 Gene

Sources for JADE1 Gene

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