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Aliases for JADE1 Gene

Aliases for JADE1 Gene

  • Jade Family PHD Finger 1 2 3
  • PHD Finger Protein 17 2 3 4
  • Jade Family PHD Finger Protein 1 3 4
  • PHF17 3 4
  • Gene For Apoptosis And Differentiation In Epithelia 3
  • PHD Protein Jade-1 3
  • Protein Jade-1 3
  • KIAA1807 4
  • PHF17, 6

External Ids for JADE1 Gene

Previous HGNC Symbols for JADE1 Gene

  • PHF17

Previous GeneCards Identifiers for JADE1 Gene

  • GC04P130189
  • GC04P129731

Summaries for JADE1 Gene

GeneCards Summary for JADE1 Gene

JADE1 (Jade Family PHD Finger 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for JADE1 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.

Gene Wiki entry for JADE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JADE1 Gene

Genomics for JADE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for JADE1 Gene

Start:
128,809,623 bp from pter
End:
128,875,224 bp from pter
Size:
65,602 bases
Orientation:
Plus strand

Genomic View for JADE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JADE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JADE1 Gene

No data available for Regulatory Elements for JADE1 Gene

Proteins for JADE1 Gene

  • Protein details for JADE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IE81-JADE1_HUMAN
    Recommended name:
    Protein Jade-1
    Protein Accession:
    Q6IE81
    Secondary Accessions:
    • D3DNY0
    • D3DNY1
    • Q4W5D5
    • Q6ZSL7
    • Q8NC41
    • Q96JL8
    • Q96SQ1
    • Q9H692

    Protein attributes for JADE1 Gene

    Size:
    842 amino acids
    Molecular mass:
    95533 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Isoform 3 interacts with VHL and KAT5.
    SequenceCaution:
    • Sequence=BAB15371.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11335.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JADE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JADE1 Gene

Proteomics data for JADE1 Gene at MOPED

Post-translational modifications for JADE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JADE1 Gene

Domains for JADE1 Gene

Gene Families for JADE1 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Graphical View of Domain Structure for InterPro Entry

Q6IE81

UniProtKB/Swiss-Prot:

JADE1_HUMAN :
  • Q6IE81
Domain:
  • The 2 PHD-type zinc fingers are required for transcriptional activity
Family:
  • Belongs to the JADE family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with JADE1: view

No data available for Suggested Antigen Peptide Sequences for JADE1 Gene

Function for JADE1 Gene

Molecular function for JADE1 Gene

UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.

Gene Ontology (GO) - Molecular Function for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity IDA 23001567
GO:0005515 protein binding IPI 12169691
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with JADE1: view

Phenotypes for JADE1 Gene

MGI mutant phenotypes for JADE1:
inferred from 1 alleles
GenomeRNAi human phenotypes for JADE1:
genes like me logo Genes that share phenotypes with JADE1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for JADE1 Gene

Localization for JADE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JADE1 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12169691
GO:0005886 plasma membrane IDA 23001567
genes like me logo Genes that share ontologies with JADE1: view

No data available for Subcellular locations from COMPARTMENTS for JADE1 Gene

Pathways for JADE1 Gene

genes like me logo Genes that share pathways with JADE1: view

Pathways by source for JADE1 Gene

Gene Ontology (GO) - Biological Process for JADE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process NAS 12169691
GO:0006950 response to stress NAS 12169691
GO:0030308 negative regulation of cell growth NAS 12169691
genes like me logo Genes that share ontologies with JADE1: view

Transcripts for JADE1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JADE1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for JADE1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JADE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: - - - - - -
SP10:

ExUns: 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for JADE1 Gene

GeneLoc Exon Structure for
JADE1
ECgene alternative splicing isoforms for
JADE1

Expression for JADE1 Gene

mRNA expression in normal human tissues for JADE1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JADE1 Gene

mRNA Expression by UniProt/SwissProt for JADE1 Gene

Q6IE81-JADE1_HUMAN
Tissue specificity: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
genes like me logo Genes that share expressions with JADE1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for JADE1 Gene

Orthologs for JADE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for JADE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF17 35
  • 99.68 (n)
  • 100 (a)
PHF17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JADE1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JADE1 36
  • 95 (a)
OneToOne
PHF17 35
  • 91.45 (n)
  • 95.61 (a)
mouse
(Mus musculus)
Mammalia Jade1 35
  • 90.3 (n)
  • 93.15 (a)
Phf17 16
Phf17 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JADE1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jade1 35
  • 90.69 (n)
  • 94.32 (a)
chicken
(Gallus gallus)
Aves JADE1 36
  • 81 (a)
OneToOne
PHF17 35
  • 77.18 (n)
  • 81.41 (a)
lizard
(Anolis carolinensis)
Reptilia JADE1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19317 35
tropical clawed frog
(Silurana tropicalis)
Amphibia jade1 35
  • 67.28 (n)
  • 70.18 (a)
zebrafish
(Danio rerio)
Actinopterygii jade1 35
  • 60.46 (n)
  • 58.37 (a)
jade1 36
  • 52 (a)
OneToOne
wufi11a04 35
fruit fly
(Drosophila melanogaster)
Insecta rno 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for JADE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JADE1 Gene

ENSEMBL:
Gene Tree for JADE1 (if available)
TreeFam:
Gene Tree for JADE1 (if available)

Paralogs for JADE1 Gene

Paralogs for JADE1 Gene

Selected SIMAP similar genes for JADE1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with JADE1: view

Variants for JADE1 Gene

Sequence variations from dbSNP and Humsavar for JADE1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1129142 -- 128,873,273(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs1425618 -- 128,819,332(+) TGGCA(C/T)GATCA intron-variant
rs1809274 -- 128,854,719(-) TTCAG(A/C)ACTTT intron-variant
rs2004378 -- 128,845,653(+) ctcat(A/G)cttgt intron-variant
rs2016294 -- 128,845,248(+) CAGGC(C/G)CAGGA intron-variant

Relevant External Links for JADE1 Gene

HapMap Linkage Disequilibrium report
JADE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JADE1 Gene

Disorders for JADE1 Gene

No disorders were found for JADE1 Gene.

No data available for UniProtKB/Swiss-Prot for JADE1 Gene

Publications for JADE1 Gene

  1. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. (PMID: 12169691) Zhou M.I. … Cohen H.T. (J. Biol. Chem. 2002) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. (PMID: 14612400) Tzouanacou E. … Wilson V. (Mol. Cell. Biol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. (PMID: 18684714) Foy R.L. … Panchenko M.V. (J. Biol. Chem. 2008) 3 23

Products for JADE1 Gene

Sources for JADE1 Gene

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