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Aliases for IL17B Gene

Aliases for IL17B Gene

  • Interleukin 17B 2 3 5
  • Neuronal Interleukin-17-Related Factor 2 4
  • IL-17B 3 4
  • ZCYTO7 3 4
  • IL-20 3 4
  • NIRF 3 4
  • Neuronal Interleukin-17 Related Factor 3
  • Cytokine-Like Protein ZCYTO7 3
  • Interleukin-17 Beta 3
  • Cytokine Zcyto7 4
  • Interleukin 20 3
  • Interleukin-20 4
  • IL20 4

External Ids for IL17B Gene

Previous GeneCards Identifiers for IL17B Gene

  • GC05M148797
  • GC05M149348
  • GC05M148782
  • GC05M148734
  • GC05M143900

Summaries for IL17B Gene

Entrez Gene Summary for IL17B Gene

  • The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for IL17B Gene

IL17B (Interleukin 17B) is a Protein Coding gene. Diseases associated with IL17B include leiomyoma. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot for IL17B Gene

  • Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17B Gene

Genomics for IL17B Gene

Regulatory Elements for IL17B Gene

Genomic Location for IL17B Gene

Chromosome:
5
Start:
149,371,324 bp from pter
End:
149,404,244 bp from pter
Size:
32,921 bases
Orientation:
Minus strand

Genomic View for IL17B Gene

Genes around IL17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17B Gene

Proteins for IL17B Gene

  • Protein details for IL17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF5-IL17B_HUMAN
    Recommended name:
    Interleukin-17B
    Protein Accession:
    Q9UHF5
    Secondary Accessions:
    • Q14CE5

    Protein attributes for IL17B Gene

    Size:
    180 amino acids
    Molecular mass:
    20437 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17B Gene

Proteomics data for IL17B Gene at MOPED

Post-translational modifications for IL17B Gene

Other Protein References for IL17B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL17B Gene

Domains & Families for IL17B Gene

Gene Families for IL17B Gene

Protein Domains for IL17B Gene

Suggested Antigen Peptide Sequences for IL17B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHF5

UniProtKB/Swiss-Prot:

IL17B_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17B: view

Function for IL17B Gene

Molecular function for IL17B Gene

GENATLAS Biochemistry:
interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding to the IL17 receptor
UniProtKB/Swiss-Prot Function:
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
genes like me logo Genes that share phenotypes with IL17B: view

Animal Model Products

miRNA for IL17B Gene

miRTarBase miRNAs that target IL17B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL17B Gene

Localization for IL17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17B Gene COMPARTMENTS Subcellular localization image for IL17B gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IL17B Gene

Pathways & Interactions for IL17B Gene

genes like me logo Genes that share pathways with IL17B: view

Pathways by source for IL17B Gene

Interacting Proteins for IL17B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261796%0d%0a9606.ENSP00000288167%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9UHF5-IL17B_HUMAN ENSP00000261796 for IL17B Gene via I2D MINT STRING

SIGNOR curated interactions for IL17B Gene

Activates:

Gene Ontology (GO) - Biological Process for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 10639155
genes like me logo Genes that share ontologies with IL17B: view

Drugs & Compounds for IL17B Gene

(1) Drugs for IL17B Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vidofludimus Pharma inhibitor 0
genes like me logo Genes that share compounds with IL17B: view

Transcripts for IL17B Gene

Unigene Clusters for IL17B Gene

Interleukin 17B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17B Gene

No ASD Table

Relevant External Links for IL17B Gene

GeneLoc Exon Structure for
IL17B
ECgene alternative splicing isoforms for
IL17B

Expression for IL17B Gene

mRNA expression in normal human tissues for IL17B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17B Gene

This gene is overexpressed in Nerve - Tibial (x14.8), Artery - Tibial (x4.8), and Artery - Aorta (x4.7).

Protein differential expression in normal tissues from HIPED for IL17B Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17B Gene



SOURCE GeneReport for Unigene cluster for IL17B Gene Hs.156979

mRNA Expression by UniProt/SwissProt for IL17B Gene

Q9UHF5-IL17B_HUMAN
Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
genes like me logo Genes that share expression patterns with IL17B: view

Protein tissue co-expression partners for IL17B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IL17B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL17B 35
  • 89.63 (n)
  • 91.67 (a)
IL17B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17B 35
  • 89.44 (n)
  • 92.22 (a)
IL17B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17b 35
  • 84.63 (n)
  • 88.33 (a)
Il17b 16
Il17b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL17B 35
  • 99.44 (n)
  • 99.44 (a)
IL17B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17b 35
  • 86.85 (n)
  • 89.44 (a)
oppossum
(Monodelphis domestica)
Mammalia IL17B 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17B 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17B 35
  • 67.43 (n)
  • 56.32 (a)
IL17B 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17B 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17b 35
  • 60.71 (n)
  • 57.62 (a)
Species with no ortholog for IL17B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17B Gene

ENSEMBL:
Gene Tree for IL17B (if available)
TreeFam:
Gene Tree for IL17B (if available)

Paralogs for IL17B Gene

Paralogs for IL17B Gene

genes like me logo Genes that share paralogs with IL17B: view

Variants for IL17B Gene

Sequence variations from dbSNP and Humsavar for IL17B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs442266 -- 149,404,415(+) CTCTC(A/G)CAATG upstream-variant-2KB
rs353257 -- 149,391,230(+) CAAAC(C/T)GCTGG intron-variant
rs353258 -- 149,391,850(+) CTGTC(A/G)TGACC intron-variant
rs353259 -- 149,392,281(+) ATCTT(G/T)TATTT intron-variant
rs353260 -- 149,393,645(+) tccta(A/C)ctccc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL17B Gene

Variant ID Type Subtype PubMed ID
nsv883023 CNV Loss 21882294

Variation tolerance for IL17B Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17B Gene

HapMap Linkage Disequilibrium report
IL17B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17B Gene

Disorders for IL17B Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL17B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma
  • leiomyomatous neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search IL17B in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL17B

Genetic Association Database (GAD)
IL17B
Human Genome Epidemiology (HuGE) Navigator
IL17B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17B
genes like me logo Genes that share disorders with IL17B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17B Gene

Publications for IL17B Gene

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PMID: 10639155) Li H. … Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23 67
  2. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. (PMID: 25732306) Wu H.H. … Lee W.H. (J. Exp. Med. 2015) 3
  3. Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-I_B-mediated antiapoptotic pathway. (PMID: 23851503) Huang C.K. … Lee W.H. (Oncogene 2014) 3
  4. Neutrophils produce interleukin-17B in rheumatoid synovial tissue. (PMID: 24056520) Kouri V.P. … Mandelin J. (Rheumatology (Oxford) 2014) 3
  5. Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients. (PMID: 23661335) Robak E. … Sysa-Jedrzejowska A. (Eur. Cytokine Netw. 2013) 3

Products for IL17B Gene

Sources for IL17B Gene

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