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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL17B Gene

protein-coding GIFtS: 53
GCID: GC05M148734

interleukin 17B

Explore 18 diseases affiliated with
IL17B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 17B¹ ²		Cytokine-Like Protein ZCYTO7²
IL-17B¹ ² ³		Interleukin 20²
IL-20¹ ² ³		Interleukin-17 Beta²
NIRF¹ ² ³		Interleukin-17B¹
ZCYTO7¹ ² ³		Interleukin-20³
Cytokine Zcyto7² ³		Neuronal Interleukin-17 Related Factor²
Neuronal Interleukin-17-Related Factor² ³		IL20³
MGC138900¹		Interleukin-20³
MGC138901¹

External Ids:	HGNC: 5982¹	Entrez Gene: 27190²	Ensembl: ENSG00000127743⁷	OMIM: 604627⁵	UniProtKB: Q9UHF5³

Export aliases for IL17B gene to outside databases

Previous GC identifers: GC05M148797 GC05M149348 GC05M148782 GC05M143900

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17B:

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine

was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line.

Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal

cell bodies. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5

Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL17B gene promoter:
AREB6 HEN1 GR Ik-2 GR-beta c-Myb GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL17B promoter sequence

Search SABiosciences Chromatin IP Primers for IL17B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q33.1

IL17B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M148734: view genomic region (about GC identifiers)

Start:	148,750,887 bp from pter	End:	148,783,765 bp from pter
Size:	32,879 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5 (See protein sequence)

Recommended Name: Interleukin-17B precursor

Size: 180 amino acids; 20437 Da

Subcellular location: Secreted

Secondary accessions: Q14CE5

Explore the universe of human proteins at neXtProt for IL17B: NX_Q9UHF5

IL17B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055258.1

ENSEMBL proteins:

ENSP00000261796

Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for IL17B (IL-17B)
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	Novus Biologicals IL17B Proteins Novus Biologicals IL17B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IL17B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

IL17B for ontologies About GeneDecksing

IL17B Antibody Products:

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	Uscn Antibodies for IL17B
	ThermoFisher Antibodies for IL17B

Assay Products for IL17B:

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	Uscn ELISAs and CLIAs for IL17B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL17B for domains About GeneDecksing

2 InterPro domains/families:

IPR020440 Interleukin-17_chordata

IPR010345 Interleukin-17

Graphical View of Domain Structure for InterPro Entry Q9UHF5

ProtoNet protein and cluster: Q9UHF5

1 Blocks protein family: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5

Similarity: Belongs to the IL-17 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5

Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

Genatlas biochemistry entry for IL17B:

interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding to

the IL17 receptor

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17B
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17B (see all 4) OriGene shRNA RFP: IL17B OriGene siRNA: IL17B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL17B

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17B (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL17B
		Search LifeMap BioReagents cell lines for IL17B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--

IL17B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Il17b^tm1Lex for IL17B
     1 MGI phenotypic allele

for Il17b (no phenotypes)

IL17B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.26

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for IL17B):

Cytokine-cytokine receptor interaction

IL17B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IL17B

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for IL17B (Q9UHF5^{2, 3} ENSP00000261796⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENO2	P09104²^,³	MINT-63443 I2D: score=5
IL17RB	Q9NRM6³, ENSP00000288167⁴	I2D: score=3 STRING: ENSP00000288167
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
--	Q6FHV6³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	TAS	10639155
GO:0007267	cell-cell signaling	TAS	10639155
GO:1900017	positive regulation of cytokine production involved in inflammatory response	IEA	--

IL17B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL17B
Search CenterWatch for drugs/clinical trials and news about IL17B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL17B gene:

NM_014443.2

Unigene Cluster for IL17B:

Interleukin 17B

Hs.156979 [show with all ESTs]

Unigene Representative Sequence: NM_014443

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000518814 ENST00000261796(uc003lqo.3) ENST00000505432

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17B
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL17B
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17B (see all 4) OriGene shRNA RFP: IL17B OriGene siRNA: IL17B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17B (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17B
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17B

Additional cDNA sequence:

AF110385.1 AF152098.1 AF184969.1 AF212311.1 AF218727.1 AY358931.1 BC113925.1 BC113946.1

CR457192.1

3 DOTS entries:

DT.310662 DT.97834163 DT.91700292

24/31 AceView cDNA sequences (see all 31):

NM_014443 AF218727 BU753501 AY358931 AI867949 AF152098 BM719497 BU741486

BM682816 BF476508 BQ574994 AA704834 AF110385 CR457192 AA680405 CA413832

AI370793 AI375503 BM826445 AA780147 AF184969 AF212311 AI375735 BM724859

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL17B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACCATCG

About this image

IL17B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Hepatic Mesenchyme

Mesothelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL17B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL17B

SOURCE GeneReport for Unigene cluster: Hs.156979

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5

Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced

expression in prostate, colon mucosal lining, and ovary

SABiosciences Expression via Pathway-Focused PCR Arrays including IL17B:

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Common Cytokines in human mouse rat

Notch Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL17B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL17B gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il17b^{1 , 5}	interleukin 17B^{1, 5}	84.63(n)¹ 88.33(a)¹		18 (34.67 cM)⁵ 56069¹ NM_019508.1¹ NP_062381.1¹ 61687935⁵
chicken (Gallus gallus)	Aves	IL17B¹	interleukin 17B	67.62(n) 56.9(a)		427620 XM_425192.3 XP_425192.3
lizard (Anolis carolinensis)	Reptilia	IL17B⁶	--	63(a)	1 ↔ 1	2(122751704-122754537)
zebrafish (Danio rerio)	Actinopterygii	il17a/f1⁶ il17a/f3⁶	interleukin 17a/f3	23(a) 21(a)	many → 1 many → 1	17(12573842-12576188) 20(34816796-34818723)

ENSEMBL Gene Tree for IL17B (if available)
TreeFam Gene Tree for IL17B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL17B gene

IL17A² IL17D² IL17F² IL17C²

IL17B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77102876^1,2		--	148753339(+)	`TTAAAG/AGAAAC`	1	--	ds500¹		1		WA	118
rs2227470^1,2	C,F,	--	148753353(-)	`CACCCG/AGCCCA`	1	--	ds500¹		4		NS WA	256
rs186910872^1,2		--	148753472(+)	`CCCCAC/TATCTA`	1	--	ds500¹		0	--	--	--	--
rs375208^1,2	C,F,	--	148753511(-)	`GTGTGT/CGCCAC`	1	--	ds500¹		11		EA NA NS	440
rs142408331^1,2		--	148753650(+)	`AGGAA-/ACACATG`	1	--	ds500¹		0	--	--	--	--
rs2227463^1,2	C,F	--	148753651(-)	`CATGTGT/-TTCCT`	1	--	ds500¹		3		NS	142
rs191278597^1,2		--	148753669(+)	`TAGGTA/GGTAGA`	1	--	ds500¹		0	--	--	--	--
rs2227462^1,2	C,F	--	148753766(-)	`CCTGGG/AAGGTA`	1	--	ds500¹		4		NS NA	140
rs115498474^1,2		--	148753803(+)	`ACTTCG/AAAGCC`	1	--	ds500¹		1		NA	120
rs138991563^1,2	C	--	148753999(+)	`CTGTGC/TGGGGC`	2	H R	mis¹		2		NA EU	5043

HapMap Linkage Disequilibrium report for IL17B (148750887 - 148783765 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL17B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17B

DNA2.0 Custom Variant and Variant Library Synthesis for IL17B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL17B for disorders           About GeneDecksing

OMIM gene information: 604627    OMIM disorders: --

18 diseases for IL17B:    About MalaCards

charcot-marie-tooth disease neuronitis tooth disease rheumatoid arthritis

lupus nephritis fanconi's anemia nephritis spondyloarthropathy

leiomyoma leiomyosarcoma arthritis psoriasis

kidney disease anemia periodontitis atherosclerosis

obesity prostatitis

7 Novoseek disease relationships for IL17B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis	58.8	16	17911452 (5), 14712309 (1), 16778121 (1), 18758357 (1)
leiomyoma	50.9	1	12761473 (1)
rheumatoid arthritis	27.4	7	18061474 (4), 18758357 (1)
inflammation	25	2	16947773 (1), 11470428 (1)
necrosis	22.3	6	16709143 (1), 10639155 (1), 18061474 (1), 18758357 (1)
arthritis	12.3	4	16947773 (3)
tumors	7.06	7	16908179 (1), 16709143 (1), 10639155 (1), 16511554 (1) (see all 5)

Genetic Association Database (GAD): IL17B
Human Genome Epidemiology (HuGE) Navigator: IL17B (3 documents)

Export disorders for IL17B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL17B gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with IL17B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)^{1, 2, 3, 9} Li H.... Wood W.I. (2000)
Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PubMed id 15713213)^{1, 4} Ryan A.W....McManus R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PubMed id 10749887)^{1, 2} Shi Y.... Ebner R. (2000)
[Eukaryotic expression and biological activity of reco mbinant human IL-17B protein]. (PubMed id 22394632)¹ Liu G.Q....Zhang X.G. (2012)
A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)¹ Shamay M....Hayward S.D. (2012)
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
Fine mapping of the CELIAC2 locus on chromosome 5q31- q33 in the Finnish and Hungarian populations. (PubMed id 19845895)¹ Koskinen L.L....Saavalainen P. (2009)
Expression profile of immune-associated genes in nasal polyps. (PubMed id 16805377)¹ Wang X....Guan B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27190	HGNC: 5982	AceView: IL17B	Ensembl:ENSG00000127743	euGenes: HUgn27190
ECgene: IL17B	Kegg: 27190	H-InvDB: IL17B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL17B	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_17
SeattleSNPs	http://pga.gs.washington.edu/data/il17b/

Intellectual Property for IL17B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL17B gene:
Search GeneIP for patents involving IL17B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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interleukin 17B

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