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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17B Gene

protein-coding   GIFtS: 53
GCID: GC05M148734

Interleukin 17B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 17B1 2     Interleukin 202
Neuronal Interleukin-17-Related Factor1 2 3     Interleukin-17 Beta2
Cytokine Zcyto72 3     interleukin-17B2
IL-17B2 3     interleukin-202
IL-202 3     Neuronal Interleukin-17 Related Factor2
NIRF2 3     IL203
ZCYTO72 3     Interleukin-203
Cytokine-Like Protein ZCYTO72     

External Ids:    HGNC: 59821   Entrez Gene: 271902   Ensembl: ENSG000001277437   OMIM: 6046275   UniProtKB: Q9UHF53   

Export aliases for IL17B gene to outside databases

Previous GC identifers: GC05M148797 GC05M149348 GC05M148782 GC05M143900


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17B Gene:
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This
cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line.
Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to
neuronal cell bodies. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL17B Gene: 
IL17B (interleukin 17B) is a protein-coding gene. Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17B gene promoter:
         AREB6   HEN1   GR   Ik-2   GR-beta   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17B promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

IL17B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M148734:  view genomic region     (about GC identifiers)

Start:
148,750,887 bp from pter      End:
148,783,765 bp from pter
Size:
32,879 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5 (See protein sequence)
Recommended Name: Interleukin-17B precursor  
Size: 180 amino acids; 20437 Da
Subcellular location: Secreted
Secondary accessions: Q14CE5

Explore the universe of human proteins at neXtProt for IL17B: NX_Q9UHF5

Explore proteomics data for IL17B at MOPED 

IL17B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL17B Protein Expression

REFSEQ proteins: NP_055258.1  
ENSEMBL proteins: 
 ENSP00000261796  

Human Recombinant Protein Products for IL17B: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL17B (IL-17B)
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL17B
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL17B
GenScript Custom Purified and Recombinant Proteins Services for IL17B
Novus Biologicals IL17B Proteins
Novus Biologicals IL17B Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for IL17B 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

IL17B for ontologies           About GeneDecksing



IL17B Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL17B (IL-17B)
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Novus Biologicals IL17B Antibodies
Abcam antibodies for IL17B
Cloud-Clone Corp. Antibodies for IL17B 
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LSBio Antibodies in human, mouse, rat for IL17B 

Assay Products for IL17B: 
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R&D Systems ELISAs for IL17B (IL-17B)
GenScript Custom Assay Services for IL17B
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL17B 
Cloud-Clone Corp. CLIAs for IL17B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

2 InterPro protein domains:
 IPR010345 Interleukin-17
 IPR020440 Interleukin-17_chordata

Graphical View of Domain Structure for InterPro Entry Q9UHF5

ProtoNet protein and cluster: Q9UHF5

1 Blocks protein domain: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
Similarity: Belongs to the IL-17 family


IL17B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL17B_HUMAN, Q9UHF5
Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

     Genatlas biochemistry entry for IL17B:
interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding
to the IL17 receptor

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
IL17B for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Il17b (no phenotypes)

IL17B for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Il17btm1Lex for IL17B

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL17B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL17B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17B 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17B 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17B
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL17B
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL17B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL17B
Sirion Biotech Customized adenovirus for overexpression of IL17B

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL17B (see all 6)
OriGene ORF clones in mouse, rat for IL17B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
Sino Biological Human cDNA Clone for IL17B
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17B
Sirion Biotech Customized lentivirus for stable overexpression of IL17B 
                     Customized lentivirus expression plasmids for stable overexpression of IL17B 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IL17B
Search LifeMap BioReagents cell lines for IL17B
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL17B About                                                                                                See pathways by source

SuperPathContained pathways About
1Mucin expression in CF via IL-6, IL-17 signaling pathways
IL-17 Signaling0.48
2PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL17B
    IL-17 Signaling




1         Kegg Pathway  (Kegg details for IL17B):
    Cytokine-cytokine receptor interaction


IL17B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17B

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for IL17B (Q9UHF52, 3 ENSP000002617964) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ENO2P091042, 3MINT-63443 I2D: score=5 
IL17RBQ9NRM63, ENSP000002881674I2D: score=3 STRING: ENSP00000288167
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
--Q6FHV63I2D: score=1 
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0006955immune response TAS10639155
GO:0007267cell-cell signaling TAS10639155
GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

IL17B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL17B

Search CenterWatch for drugs/clinical trials and news about IL17B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL17B gene: 
NM_014443.2  

Unigene Cluster for IL17B:

Interleukin 17B
Hs.156979  [show with all ESTs]
Unigene Representative Sequence: NM_014443
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000518814 ENST00000261796(uc003lqo.3) ENST00000505432
miRNA
Products:
     
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL17B
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL17B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17B
Clone
Products:
     
OriGene clones in human, mouse for IL17B (see all 6)
OriGene ORF clones in mouse, rat for IL17B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17B
Sirion Biotech Customized lentivirus for stable overexpression of IL17B 
                     Customized lentivirus expression plasmids for stable overexpression of IL17B 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IL17B
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL17B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17B

Additional mRNA sequence: 

AF110385.1 AF152098.1 AF184969.1 AF212311.1 AF218727.1 AY358931.1 BC113925.1 BC113946.1 
CR457192.1 

3 DOTS entries:

DT.310662  DT.97834163  DT.91700292 

24/31 AceView cDNA sequences (see all 31):

AI867949 AF152098 BU753501 AF218727 NM_014443 AY358931 BM682816 BM719497 
BU741486 AA704834 BQ574994 AA443286 BF476508 BM724859 AF110385 AA680405 
AA780147 AF184969 AI370793 BM826445 AI375503 AF212311 AI375735 CR457192 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL17B expression in normal human tissues (normalized intensities)      IL17B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGACCATCG
IL17B Expression
About this image


IL17B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Zeugopod Long Bone
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Intestine (Gastrointestinal Tract)
         ileum   
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 Gonad
         Secondary Oocyte Antral Follicle

See IL17B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL17B

SOURCE GeneReport for Unigene cluster: Hs.156979

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced
expression in prostate, colon mucosal lining, and ovary

    SABiosciences Expression via Pathway-Focused PCR Arrays including IL17B: 
          Th17 Response in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Notch Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL17B
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL17B gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il17b1 , 5 interleukin 17B1, 5 84.63(n)1
88.33(a)1
  18 (34.67 cM)5
560691  NM_019508.11  NP_062381.11 
 616879355 
chicken
(Gallus gallus)
Aves IL17B1 interleukin 17B 67.62(n)
56.9(a)
  427620  XM_425192.3  XP_425192.3 
lizard
(Anolis carolinensis)
Reptilia IL17B6
Uncharacterized protein
48(a)
1 ↔ 1
2(122749366-122754558)


ENSEMBL Gene Tree for IL17B (if available)
TreeFam Gene Tree for IL17B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IL17B gene
IL17D2  

IL17B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/173 SNPs in IL17B are shown (see all 173)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs771028761,2
F--148753339(+) TTAAAG/AGAAAC 1 -- ds50011Minor allele frequency- A:0.01WA 118
rs22274701,2
C,F--148753353(-) cacccG/AgccCA 1 -- ds50014Minor allele frequency- A:0.02NS WA 256
rs1869108721,2
--148753472(+) CCCCAC/TATCTA 1 -- ds50010--------
rs3752081,2
C,F--148753511(-) GTGTGT/CGCCAC 1 -- ds500111Minor allele frequency- C:0.13EA NA NS 440
rs22274631,2
C,F--148753650(-) CATGTGT/-TTCCT 1 -- ds50013Minor allele frequency- -:0.01NS 142
rs1912785971,2
C--148753669(+) TAGGTA/GGTAGA 1 -- ds50010--------
rs22274621,2
C,F--148753766(-) CCTGGG/AAGGTA 1 -- ds50014Minor allele frequency- A:0.01NS NA 140
rs1154984741,2
C,F--148753803(+) ACTTCG/AAAGCC 1 -- ds50011Minor allele frequency- A:0.01NA 120
rs1389915631,2
C--148753999(+) CTGTGC/TGGGGC 2 H R mis12Minor allele frequency- T:0.00NA EU 5043
rs1499082631,2
C,F--148754005(+) GGGGCG/AGTGGC 2 /P /L mis11Minor allele frequency- A:0.00NA 4132

HapMap Linkage Disequilibrium report for IL17B (148750887 - 148783765 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL17B:    About this table     
Variant IDTypeSubtypePubMed ID
nsv883023CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL17B
DNA2.0 Custom Variant and Variant Library Synthesis for IL17B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604627    OMIM disorders: --

20 diseases for IL17B:    About MalaCards
spondyloarthropathy    neuronitis    leiomyoma    lupus nephritis
psoriasis    leiomyosarcoma    tooth disease    charcot-marie-tooth disease
nephritis    fanconi's anemia    rheumatoid arthritis    arthritis
kidney disease    periodontitis    anemia    atherosclerosis
kaposi's sarcoma    obesity    sarcoma    prostatitis


IL17B for disorders           About GeneDecksing

7 Novoseek inferred disease relationships for IL17B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 58.8 16 17911452 (5), 14712309 (1), 16778121 (1), 18758357 (1)
leiomyoma 50.9 1 12761473 (1)
rheumatoid arthritis 27.4 7 18061474 (4), 18758357 (1)
inflammation 25 2 16947773 (1), 11470428 (1)
necrosis 22.3 6 16709143 (1), 10639155 (1), 18061474 (1), 18758357 (1)
arthritis 12.3 4 16947773 (3)
tumors 7.06 7 16908179 (1), 16709143 (1), 10639155 (1), 16511554 (1) (see all 5)

Genetic Association Database (GAD): IL17B
Human Genome Epidemiology (HuGE) Navigator: IL17B (3 documents)

Export disorders for IL17B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL17B gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with IL17B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)1, 2, 3, 9 Li H.... Wood W.I. (2000)
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31- q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (2009)
  3. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PubMed id 15713213)1, 4 Ryan A.W....McManus R. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PubMed id 10749887)1, 2 Shi Y.... Ebner R. (2000)
  7. [Eukaryotic expression and biological activity of reco mbinant human IL-17B protein]. (PubMed id 22394632)1 Liu G.Q....Zhang X.G. (2012)
  8. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
  9. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
  10. Expression profile of immune-associated genes in nasal polyps. (PubMed id 16805377)1 Wang X....Guan B. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 27190 HGNC: 5982 AceView: IL17B Ensembl:ENSG00000127743 euGenes: HUgn27190
ECgene: IL17B Kegg: 27190 H-InvDB: IL17B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL17B Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Interleukin_17
SeattleSNPshttp://pga.gs.washington.edu/data/il17b/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL17B gene:
Search GeneIP for patents involving IL17B

GeneCards and IP:
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