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Aliases for IL17B Gene

Aliases for IL17B Gene

  • Interleukin 17B 2 3
  • Neuronal Interleukin-17-Related Factor 2 3 4
  • Cytokine Zcyto7 3 4
  • Interleukin-20 3 4
  • IL-17B 3 4
  • ZCYTO7 3 4
  • IL-20 3 4
  • NIRF 3 4
  • Neuronal Interleukin-17 Related Factor 3
  • Cytokine-Like Protein ZCYTO7 3
  • Interleukin-17 Beta 3
  • Interleukin-17B 3
  • Interleukin 20 3
  • IL20 4

External Ids for IL17B Gene

Previous GeneCards Identifiers for IL17B Gene

  • GC05M148797
  • GC05M149348
  • GC05M148782
  • GC05M148734
  • GC05M143900

Summaries for IL17B Gene

Entrez Gene Summary for IL17B Gene

  • The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17B Gene

IL17B (Interleukin 17B) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot for IL17B Gene

  • Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17B Gene

Genomics for IL17B Gene

Regulatory Elements for IL17B Gene

Genomic Location for IL17B Gene

Start:
149,371,324 bp from pter
End:
149,404,202 bp from pter
Size:
32,879 bases
Orientation:
Minus strand

Genomic View for IL17B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17B Gene

Proteins for IL17B Gene

  • Protein details for IL17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF5-IL17B_HUMAN
    Recommended name:
    Interleukin-17B
    Protein Accession:
    Q9UHF5
    Secondary Accessions:
    • Q14CE5

    Protein attributes for IL17B Gene

    Size:
    180 amino acids
    Molecular mass:
    20437 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17B Gene

Proteomics data for IL17B Gene at MOPED

Post-translational modifications for IL17B Gene

Other Protein References for IL17B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17B Gene

Domains for IL17B Gene

Gene Families for IL17B Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL17B Gene

Suggested Antigen Peptide Sequences for IL17B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHF5

UniProtKB/Swiss-Prot:

IL17B_HUMAN :
  • Q9UHF5
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17B: view

Function for IL17B Gene

Molecular function for IL17B Gene

GENATLAS Biochemistry: interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding to the IL17 receptor
UniProtKB/Swiss-Prot Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

Gene Ontology (GO) - Molecular Function for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IL17B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL17B Gene

Localization for IL17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17B Gene COMPARTMENTS Subcellular localization image for IL17B gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL17B: view

Pathways for IL17B Gene

genes like me logo Genes that share pathways with IL17B: view

Pathways by source for IL17B Gene

1 BioSystems pathway for IL17B Gene
1 R&D Systems pathway for IL17B Gene

Interacting Proteins for IL17B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261796%0d%0a9606.ENSP00000288167%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9UHF5-IL17B_HUMAN ENSP00000261796 for IL17B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 10639155
GO:0007267 cell-cell signaling TAS 10639155
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17B: view

Transcripts for IL17B Gene

Unigene Clusters for IL17B Gene

Interleukin 17B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17B Gene

No ASD Table

Relevant External Links for IL17B Gene

GeneLoc Exon Structure for
IL17B
ECgene alternative splicing isoforms for
IL17B

Expression for IL17B Gene

mRNA expression in normal human tissues for IL17B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17B Gene

This gene is overexpressed in Nerve - Tibial (14.8), Artery - Tibial (4.8), and Artery - Aorta (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL17B Gene

SOURCE GeneReport for Unigene cluster for IL17B Gene Hs.156979

mRNA Expression by UniProt/SwissProt for IL17B Gene

Q9UHF5-IL17B_HUMAN
Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary
genes like me logo Genes that share expressions with IL17B: view

Orthologs for IL17B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17B 35
  • 99.44 (n)
  • 99.44 (a)
IL17B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17B 35
  • 89.63 (n)
  • 91.67 (a)
IL17B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17B 35
  • 89.44 (n)
  • 92.22 (a)
IL17B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17b 35
  • 84.63 (n)
  • 88.33 (a)
Il17b 16
Il17b 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17B 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17B 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17b 35
  • 86.85 (n)
  • 89.44 (a)
chicken
(Gallus gallus)
Aves IL17B 35
  • 67.43 (n)
  • 56.32 (a)
IL17B 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17B 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17b 35
  • 60.71 (n)
  • 57.62 (a)
Species with no ortholog for IL17B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17B Gene

ENSEMBL:
Gene Tree for IL17B (if available)
TreeFam:
Gene Tree for IL17B (if available)

Paralogs for IL17B Gene

Paralogs for IL17B Gene

genes like me logo Genes that share paralogs with IL17B: view

Variants for IL17B Gene

Sequence variations from dbSNP and Humsavar for IL17B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs353257 -- 149,391,230(+) CAAAC(C/T)GCTGG intron-variant
rs353258 -- 149,391,850(+) CTGTC(A/G)TGACC intron-variant
rs353259 -- 149,392,281(+) ATCTT(G/T)TATTT intron-variant
rs353260 -- 149,393,645(+) tccta(A/C)ctccc intron-variant
rs353261 -- 149,394,287(+) aactg(C/G)ggcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17B Gene

Variant ID Type Subtype PubMed ID
nsv883023 CNV Loss 21882294

Relevant External Links for IL17B Gene

HapMap Linkage Disequilibrium report
IL17B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17B Gene

Disorders for IL17B Gene

(7) Novoseek inferred disease relationships for IL17B Gene

Disease -log(P) Hits PubMed IDs
psoriasis 58.8 8
leiomyoma 50.9 1
rheumatoid arthritis 27.4 5
inflammation 25 2
necrosis 22.3 4

Relevant External Links for IL17B

Genetic Association Database (GAD)
IL17B
Human Genome Epidemiology (HuGE) Navigator
IL17B
genes like me logo Genes that share disorders with IL17B: view

No data available for UniProtKB/Swiss-Prot for IL17B Gene

Publications for IL17B Gene

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PMID: 10639155) Li H. … Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PMID: 15713213) Ryan A.W. … McManus R. (Tissue Antigens 2005) 3 48
  5. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3 48

Products for IL17B Gene

Sources for IL17B Gene

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