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ICOS Gene

protein-coding GIFtS: 65

GC02P204509

inducible T-cell co-stimulator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AILIM ^¹, ², ³, ⁵
CD278 ^¹, ²
MGC39850 ^²

Descriptions
Activation-inducible lymphocyte immunomediatory molecule ^², ³
CD278 antigen ^³
inducible T-cell co-stimulator ^²
inducible costimulator ^²

External Ids
HGNC: 5351¹
Entrez Gene: 29851²
UniProtKB: Q9Y6W8³
Ensembl: ENSG00000163600⁷

Search outside databases for aliases for ICOS gene

Previous GC identifers: GC02P203018 GC02P203526 GC02P204765 GC02P205004 GC02P204626

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICOS:

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It

forms homodimers and plays an important role in cell-cell signaling, immune responses, and

regulation of cell proliferation. [provided by RefSeq]

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8

Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion

of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help

for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells

and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the

production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the

apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of

immunoglobin isotypes (By similarity)

Gene Wiki entry for ICOS (CD278)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICOS gene

Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.2 HGNC cytogenetic band: 2q33

ICOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P204509: (about GC identifiers)

Start:	204,509,716 bp from pter
End:	204,534,545 bp from pter
Size:	24,830 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8 (See protein sequence)

Recommended Name: Inducible T-cell costimulator precursor

Size: 199 amino acids; 22625 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)

Subcellular location: Isoform 2: Secreted (Potential)

Secondary accessions: Q8N6W8

Alternative splicing: 2 isoforms: Q9Y6W8-1 Q9Y6W8-2

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036224.1

ENSEMBL proteins:

ENSP00000319476

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ICOS
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICOS)
	Human Recombinant Proteins from Abnova (ICOS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

About this table

Antibodies for ICOS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ICOS
	R&D Systems Antibodies for ICOS
	Antibodies from Abcam (ICOS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICOS)
	Novus Biologicals Antibodies for ICOS

Assays for ICOS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y6W8

ProtoNet protein and cluster: Q9Y6W8

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICOS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICOS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012092

Applied Biosystems Silencer® siRNAs for ICOS

Sigma-Aldrich siRNA for ICOS

Sigma-Aldrich shRNA Panels and shRNA for ICOS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICOS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012092
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012092
untagged cDNA clone in CMV expression vector: NM_012092

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012092

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8

Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion

of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help

for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells

and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the

production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the

apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of

immunoglobin isotypes (By similarity)

Induction: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and

continues to be expressed into the later phases of T-cell activation

5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Icos):

digestive/alimentary

endocrine/exocrine gland

hematopoietic system

homeostasis/metabolism

immune system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ICOS (Your Favorite Gene powered by Ingenuity)

iCOS-iCOSL Signaling in T Helper Cells

GeneDecks ICOS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ICOS

5/49 Interacting proteins for ICOS (ENSP00000319476³) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICOSLG	ENSP00000339477³	STRING (score=.999)
IL2	ENSP00000226730³	STRING (score=.992)
CD40LG	ENSP00000359663³	STRING (score=.984)
CD80	ENSP00000264246³	STRING (score=.967)
CTLA4	ENSP00000303939³	STRING (score=.967)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	NAS	9930702

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICOS
1 Novoseek chemical compound relationship for ICOS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	47.92	2	18025189 (1), 15963052 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICOS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICOS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012092

Sigma-Aldrich siRNA for ICOS

Sigma-Aldrich shRNA Panels and shRNA for ICOS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012092

REFSEQ mRNAs for ICOS gene:

NM_012092.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012092

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012092
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012092
                                 untagged cDNA clone in CMV expression vector: NM_012092

Additional cDNA sequence:

AB023135.1 AJ277832.1 AK314985.1 BC028006.1 BC028210.1

2 DOTS entries:

DT.40113835 DT.95364711

16 AceView cDNA sequences:

AJ277832 BC028210 AB023135 BI907838 BF061888 BC028006 NM_012092 BI907242

BX116591 CB528580 W57945 AW451448 BI818907 W58028 CD709661 AW188759

highest scoring ESTs for ICOS:

AB023135 AJ277832 AW188759 AW451448 BC028006 BC028210 BF061888 BF829501 BI818907 BI907242

Unigene Cluster for ICOS:

Inducible T-cell co-stimulator

Hs.56247 [show with all ESTs]

Unigene Representative Sequence: BC028210

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ICOS

ExUns:	1	^	2	^	3	^	4
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for ICOS

1 Ensembl transcript including schematic representation:

ENST00000316386

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICOS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICOS

¹ / ² / ³

3 probe-sets matching ICOS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34607_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB023135	1.00	1.00	1.00	1
210439_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB023135	1.00	1.00	1.00	1
210439_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICOS for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.56247
Expression variation in blood from EXPOLDB for ICOS
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely
associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell
maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes.
Expressed in the medulla of fetal and newborn thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICOS gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICOS¹	--	inducible T-cell co-stimulator	84.26(n) 71.57(a)	403456 NM_001002972.1 NP_001002972.1
chimpanzee (Pan troglodytes)	ICOS¹	--	inducible T-cell co-stimulator	99.16(n) 99.5(a)	747295 XM_001173460.1 XP_001173460.1
cow (Bos taurus)	ICOS¹	--	inducible T-cell co-stimulator	83.84(n) 73.74(a)	507026 NM_001034275.1 NP_001029447.1
mouse (Mus musculus)	Icos^{1, 5}	1 (32.00 cM)⁵	inducible T-cell co-stimulator^{1, 5}	77.95(n)¹ 69.7(a)¹	54167¹ NM_017480.1¹ NP_059508.1¹ AA596654⁵ AA655889⁵ (see all 19)
chicken (Gallus gallus)	ICOS¹	--	inducible T-cell co-stimulator	49.38(n) 33.33(a)	424105 XM_421959.2 XP_421959.1

About this table Species with no ortholog for ICOS

ENSEMBL Gene Tree for ICOS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/143 NCBI SNPs in ICOS are shown (see all 143 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 78)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4452124^1,2	A,C,F,H	204507942(+)	`agcccT/Cgtgtc`	1	--	ng5¹ tfbs³		4		EU EA WA	418
	rs11883722^1,2	A,C,F,H	204509090(+)	`GGGATG/AGGGAG`	1	--	ng5¹		4		EU EA WA	390
	rs4404254^1,2	A,C,F,H	204533531(+)	`TTTAGT/CTCTTT`	1	--	ut3¹		12		EU EA WA	1258
	rs4675379^1,2	A,C,F,H	204534340(+)	`GAGGAG/CAACCT`	1	--	ut3¹ trp³		7		EU EA WA NA	562
	rs10183087^1,2	A,C,F,H	204532569(+)	`ATAATA/CTGGAA`	1	--	ut3¹ ese³		8		EU EA WA	840
	rs10932037^1,2	C,F,H	204533591(+)	`ATTCTC/TATGGG`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs10932036^1,2	C,F,H	204533426(+)	`GTTCAA/TGTTAG`	1	--	ut3¹ ese³		12		EU EA WA	1256
	rs1559931^1,2	C,F,H	204533974(+)	`AATATA/GTGGAA`	1	--	ut3¹ ese³		9		EU EA WA NA	1507
	rs10932038^1,2	C,F,H	204533829(+)	`CCTGCA/GTTCAT`	1	--	ut3¹ ese³		8		EU EA WA	836
--	rs11889352^1,2	A,C	204508916(+)	`ctataA/Ttcata`	1	--	ng5¹ tfbs³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ICOS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604558 disorders: 607594

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8

Defects in ICOS are the cause of ICOS deficiency (ICOSD) [MIM:607594]. ICOSD is a form of

common variable immunodeficiency (CVID) characterized by recurrent bacterial infections of the

respiratory and digestive tracts characteristic of humoral immunodeficiency. There is absence of

other complicating features of CVID such as splenomegaly, autoimmune phenomena, or sarcoid-like

granulomas and absence of clinical signs of overt T-cell immunodeficiency. A severe disturbance of

the T-cell-dependent B-cell maturation occurs in secondary lymphoid tissue. B-cells exhibit a

naive IgD+/IgM+ phenotype and the numbers of IgM memory and switched memory B-cells are

substantially reduced

6 Novoseek disease relationships for ICOS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
icos deficiency	93.22	7	16757923 (4), 16630927 (1), 12577056 (1)
common variable immunodeficiency	77.01	3	16757923 (1), 12577056 (1), 15963052 (1)
autoimmune diseases	31.95	4	12753665 (1), 11904679 (1), 16187941 (1)
lupus erythematosus systemic	24.41	1	17000707 (1)
autoimmunity	8.86	1	16026134 (1)
inflammation	0.00	2	14731127 (2)

About this table

GeneTests: ICOS

Common Variable Immune Deficiency

Human Gene Mutation Database: ICOS
Genetic Association Database: ICOS
Human Genome Epidemiology Navigator: ICOS (26 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/116 PubMed articles for ICOS gene (see all 116 ):

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. (PubMed id 9930702)^{2, 3, 4} Hutloff A.... Kroczek R.A. (1999)
Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. (PubMed id 14610488)^{1, 3, 6} Lee W.I....Ochs H.D. (2003)
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. (PubMed id 12577056)^{1, 3, 4} Grimbacher B.... Peter H.H. (2003)
Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. (PubMed id 16112024)^{1, 3, 6} Guzman V.B....Gerbase-Delima M. (2005)
Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. (PubMed id 12753665)^{1, 3, 4} Haaning Andersen A.D.... Lillevang S.T. (2003)
T-cell co-stimulation through B7RP-1 and ICOS. (PubMed id 10617205)^{1, 2, 3} Yoshinaga S.K....Senaldi G. (1999)
Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population. (PubMed id 16237465)^{3, 6} Brophy K....McManus R. (2006)
Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma. (PubMed id 15953005)^{3, 6} Piras G....Gabbas A. (2005)
A common CTLA4 haplotype associated with coeliac disease. (PubMed id 15657618)^{3, 6} Hunt K.A.... van Heel D.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 29851	HGNC: 5351	AceView: ICOS	Ensembl:ENSG00000163600	euGenes: HUgn29851
ECgene: ICOS	H-InvDB: ICOS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ICOSbase	http://bioinf.uta.fi/ICOSbase/
GeneReviews	http://www.genetests.org/query?gene=ICOS

Licensable Technologies for ICOS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICOS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICOS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICOS		Antibodies for ICOS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICOS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICOS)
	Antibodies (ICOS)
	Chimera RNAi (ICOS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ICOS)
	Antibodies (ICOS)

Search OriGene for ICOS

Search Tocris compounds for ICOS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICOS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ICOS Gene at Home site.
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ICOS Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ICOS

Summaries
for ICOS

Genomic Location
for ICOS

Proteins
for ICOS

Protein Domains/
Families
for ICOS

Gene Function
for ICOS

Pathways & Interactions
for ICOS

Drugs & Compounds
for ICOS

Transcripts
for ICOS

Expression
for ICOS

Orthologs
for ICOS

Paralogs
for ICOS

SNPs/Variants
for ICOS

Disorders & Mutations
for ICOS

Medical News
for ICOS

Publications
for ICOS

Search for ICOS

Genome Databases showing ICOS

Other Databases showing ICOS

Specialized Databases showing ICOS

Licensable Technologies
for ICOS

Services
for ICOS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICOS Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ICOS

Summariesfor ICOS

Genomic Locationfor ICOS

Proteinsfor ICOS

Protein Domains/Familiesfor ICOS

Gene Functionfor ICOS

Pathways & Interactionsfor ICOS

Drugs & Compoundsfor ICOS

Transcriptsfor ICOS

Expression for ICOS

Orthologsfor ICOS

Paralogsfor ICOS

SNPs/Variantsfor ICOS

Disorders & Mutationsfor ICOS

Medical Newsfor ICOS

Publicationsfor ICOS

Search for ICOS

Genome Databases showing ICOS

Other Databases showing ICOS

Specialized Databases showing ICOS

Licensable Technologiesfor ICOS

Servicesfor ICOS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICOS

Summaries
for ICOS

Genomic Location
for ICOS

Proteins
for ICOS

Protein Domains/
Families
for ICOS

Gene Function
for ICOS

Pathways & Interactions
for ICOS

Drugs & Compounds
for ICOS

Transcripts
for ICOS

Expression
for ICOS

Orthologs
for ICOS

Paralogs
for ICOS

SNPs/Variants
for ICOS

Disorders & Mutations
for ICOS

Medical News
for ICOS

Publications
for ICOS

Licensable Technologies
for ICOS

Services
for ICOS