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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IZUMO4 Gene

protein-coding   GIFtS: 43
GCID: GC19P002085

IZUMO Family Member 4

(Previous name: chromosome 19 open reading frame 36)
(Previous symbol: C19orf36)
  Search for IZUMO4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IZUMO Family Member 41 2     IMAGE:42153392
C19orf361 2 3     Izumo Sperm-Egg Fusion Protein 42
Sperm 22 KDa Protein C1132 3     Putative SAMP14 Binding Protein Variant 12
Chromosome 19 Open Reading Frame 361     Putative SAMP14 Binding Protein Variant 22

External Ids:    HGNC: 269501   Entrez Gene: 1131772   Ensembl: ENSG000000998407   UniProtKB: Q1ZYL83   

Export aliases for IZUMO4 gene to outside databases

Previous GC identifer: GC19P001869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IZUMO4 Gene: 
IZUMO4 (IZUMO family member 4) is a protein-coding gene. Among its related super-pathways are Interaction With The Zona Pellucida.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IZUMO4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IZUMO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IZUMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

IZUMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IZUMO4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002085:  view genomic region     (about GC identifiers)

Start:
2,096,380 bp from pter      End:
2,099,592 bp from pter
Size:
3,213 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8 (See protein sequence)
Recommended Name: Izumo sperm-egg fusion protein 4 precursor  
Size: 232 amino acids; 26510 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Izumo is the name of a Japanese shrine to marriage
Sequence caution: Sequence=AAH10443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7RA93 A7RA94 Q6UXA2 Q96FT6 Q96L02
Alternative splicing: 4 isoforms:  Q1ZYL8-1   Q1ZYL8-2   Q1ZYL8-3   Q1ZYL8-4   

Explore the universe of human proteins at neXtProt for IZUMO4: NX_Q1ZYL8

Explore proteomics data for IZUMO4 at MOPED 

IZUMO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IZUMO4 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001026905.2  NP_001034935.1  

ENSEMBL proteins: 
 ENSP00000378718   ENSP00000378712   ENSP00000378709  
Reactome Protein details: Q1ZYL8
Human Recombinant Protein Products for IZUMO4: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

IZUMO4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q1ZYL8

UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8
Similarity: Belongs to the Izumo family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 MGI phenotypic allele for Izumo4 (no phenotypes)

IZUMO4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Izumo4tm1Lex for IZUMO4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IZUMO4 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IZUMO4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Fertilization
Fertilization0.38
Reproduction0.38
2Sperm:Oocyte Membrane Binding
Sperm:Oocyte Membrane Binding

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



3        Reactome Pathways for IZUMO4
    Fertilization
Reproduction
Sperm:Oocyte Membrane Binding



IZUMO4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IZUMO4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IZUMO4 (IZUM4)

Search CenterWatch for drugs/clinical trials and news about IZUMO4 / IZUM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IZUMO4 gene (3 alternative transcripts): 
NM_052878.1  NM_001031735.2  NM_001039846.1  

Unigene Cluster for IZUMO4:

IZUMO family member 4
Hs.424049  [show with all ESTs]
Unigene Representative Sequence: BC040964
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000481489 ENST00000395307 ENST00000497445 ENST00000478879(uc002luw.1 uc010xgw.1)
ENST00000395301 ENST00000498554 ENST00000590985 ENST00000591894 ENST00000588003
ENST00000593185 ENST00000395296
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Inhib. RNA
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Additional mRNA sequence: 

AK294083.1 AK301957.1 AY753639.1 BC014609.2 BC040964.1 DQ196309.1 DQ196310.1 DQ424900.1 

11 DOTS entries:

DT.423686  DT.86841481  DT.95182218  DT.100788170  DT.312897  DT.101982266  DT.100788169  DT.95182217 
DT.121414692  DT.453508  DT.95182213 

24/86 AceView cDNA sequences (see all 86):

AY358444 CD672070 CA396282 BX378854 BI825218 NM_052878 AA789135 BU623084 
BI828436 CD245930 BI825523 AA431731 BG723934 BI826670 BM853351 BV202125 
BI831745 BI827974 BM847462 BI827887 BI830254 AW182303 AI004977 BI827131 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO4    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:                                                                                    
SP2:                                            -                                       
SP3:                                            -                                       
SP4:                                            -                                       
SP5:                                            -                                       


ECgene alternative splicing isoforms for IZUMO4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IZUMO4 expression in normal human tissues (normalized intensities)      IZUMO4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAGCTGAG
IZUMO4 Expression
About this image


IZUMO4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Brain (Nervous System)    fully expand to see all 2 entries
         ganglion/cranial/trigeminal V   
 
 Peripheral Nervous System (Nervous System)
         spinal/ganglion/dorsal root ganglion   
 
 Gonad
         XY Germ Cells Testis Cord
 
 Spinal Cord (Nervous System)
         spinal/ganglion/dorsal root ganglion   

See IZUMO4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IZUMO4

SOURCE GeneReport for Unigene cluster: Hs.424049

UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8
Tissue specificity: Detected in sperm

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IZUMO4 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Izumo41 , 5 IZUMO family member 41, 5 82.64(n)1
79.26(a)1
  10 (39.72 cM)5
715641  NM_027829.31  NP_082105.31 
 807026935 


ENSEMBL Gene Tree for IZUMO4 (if available)
TreeFam Gene Tree for IZUMO4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IZUMO4 gene
1 SIMAP similar gene for IZUMO4 using alignment to 2 protein entries:     IZUM4_HUMAN (see all proteins):
C19orf36

IZUMO4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 SNPs in IZUMO4 are shown (see all 128)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0509114
----see VAR_0509112 F L mis40--------
VAR_0306834
----see VAR_0306832 A T mis40--------
VAR_0616304
----see VAR_0616302 Y F mis40--------
rs1125284321,2
C--2098285(+) CCACAA/C/GGTCCT 2 -- spa11CSA 1
rs1398123801,2
C,F--2098291(+) GTCCTC/TGGCGC 4 S L mis12Minor allele frequency- T:0.00NA EU 5643
rs1432103841,2
C,F--2098294(+) CTCGGC/TGCAGT 4 A V mis12Minor allele frequency- T:0.00NA EU 5657
rs1489045191,2
C,F--2098318(+) CCAGGG/ACCTCC 4 /D /G mis11Minor allele frequency- A:0.00NA 4546
rs1880726241,2
C--2098371(+) CCTGGG/ACCTGG 2 -- int11Minor allele frequency- A:0.00EU 593
rs2013529101,2
C,F--2098386(+) GAACAC/TTGGCC 2 -- int11Minor allele frequency- T:0.01EU 1297
rs1413386931,2
C--2098388(+) ACACTA/GGCCAC 2 -- int10--------

HapMap Linkage Disequilibrium report for IZUMO4 (2096380 - 2099592 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/15 variations for IZUMO4 (see all 15):    About this table     
Variant IDTypeSubtypePubMed ID
nsv470107CNV Loss18288195
nsv910625CNV Loss21882294
dgv3614n71CNV Loss21882294
dgv3629n71CNV Loss21882294
nsv910619CNV Loss21882294
nsv910499CNV Loss21882294
dgv3626n71CNV Loss21882294
dgv3624n71CNV Loss21882294
dgv3622n71CNV Loss21882294
dgv3612n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IZUMO4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IZUMO4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
  2. Positive Selection and the Evolution of izumo Genes in Mammals. (PubMed id 22957301)1, 3 Grayson P. and Civetta A. (2012)
  3. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PubMed id 19658160)1, 3 Ellerman D.A....Primakoff P. (2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 113177 HGNC: 26950 AceView: C19orf36 Ensembl:ENSG00000099840 euGenes: HUgn113177
ECgene: IZUMO4 H-InvDB: IZUMO4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IZUMO4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IZUMO4 gene:
Search GeneIP for patents involving IZUMO4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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