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Aliases for IZUMO4 Gene

Aliases for IZUMO4 Gene

  • IZUMO Family Member 4 2 3
  • Sperm 22 KDa Protein C113 3 4
  • C19orf36 3 4
  • Putative SAMP14 Binding Protein Variant 1 3
  • Putative SAMP14 Binding Protein Variant 2 3
  • Chromosome 19 Open Reading Frame 36 2
  • Izumo Sperm-Egg Fusion Protein 4 3
  • IMAGE:4215339 3

External Ids for IZUMO4 Gene

Previous Symbols for IZUMO4 Gene

  • C19orf36

Summaries for IZUMO4 Gene

GeneCards Summary for IZUMO4 Gene

IZUMO4 (IZUMO Family Member 4) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO4 Gene

Genomics for IZUMO4 Gene

Genomic Location for IZUMO4 Gene

2,096,423 bp from pter
2,099,593 bp from pter
3,171 bases
Plus strand

Genomic View for IZUMO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IZUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO4 Gene

No data available for Regulatory Elements for IZUMO4 Gene

Proteins for IZUMO4 Gene

  • Protein details for IZUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Izumo sperm-egg fusion protein 4
    Protein Accession:
    Secondary Accessions:
    • A7RA93
    • A7RA94
    • Q6UXA2
    • Q96FT6
    • Q96L02

    Protein attributes for IZUMO4 Gene

    232 amino acids
    Molecular mass:
    26510 Da
    Quaternary structure:
    No Data Available
    • Izumo is the name of a Japanese shrine to marriage
    • Sequence=AAH10443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IZUMO4 Gene


neXtProt entry for IZUMO4 Gene

Proteomics data for IZUMO4 Gene at MOPED

Post-translational modifications for IZUMO4 Gene

  • Glycosylation at Asn24 and Asn219

Other Protein References for IZUMO4 Gene

No data available for DME Specific Peptides for IZUMO4 Gene

Domains for IZUMO4 Gene

Protein Domains for IZUMO4 Gene



  • Belongs to the Izumo family.:
    • Q1ZYL8
genes like me logo Genes that share domains with IZUMO4: view

No data available for Gene Families for IZUMO4 Gene

Function for IZUMO4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IZUMO4 Gene

Localization for IZUMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO4 Gene


Subcellular locations from

Jensen Localization Image for IZUMO4 Gene COMPARTMENTS Subcellular localization image for IZUMO4 gene
Compartment Confidence
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for IZUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with IZUMO4: view

Pathways for IZUMO4 Gene

SuperPathways for IZUMO4 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO4: view

Pathways by source for IZUMO4 Gene

3 Reactome pathways for IZUMO4 Gene

Interacting Proteins for IZUMO4 Gene

Gene Ontology (GO) - Biological Process for IZUMO4 Gene


Transcripts for IZUMO4 Gene

Unigene Clusters for IZUMO4 Gene

IZUMO family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for IZUMO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IZUMO4 Gene

mRNA expression in normal human tissues for IZUMO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO4 Gene

This gene is overexpressed in Testis (24.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IZUMO4 Gene

SOURCE GeneReport for Unigene cluster for IZUMO4 Gene Hs.424049

mRNA Expression by UniProt/SwissProt for IZUMO4 Gene

Tissue specificity: Detected in sperm.
genes like me logo Genes that share expressions with IZUMO4: view

Orthologs for IZUMO4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IZUMO4 36
  • 98.99 (n)
  • 97.84 (a)
  • 80 (a)
(Bos Taurus)
Mammalia IZUMO4 36
  • 86.58 (n)
  • 84.42 (a)
  • 84 (a)
(Canis familiaris)
Mammalia IZUMO4 36
  • 87 (n)
  • 86.24 (a)
  • 86 (a)
(Mus musculus)
Mammalia Izumo4 36
  • 82.64 (n)
  • 78.8 (a)
Izumo4 16
Izumo4 37
  • 76 (a)
(Rattus norvegicus)
Mammalia Izumo4 36
  • 83.26 (n)
  • 80.18 (a)
Species with no ortholog for IZUMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO4 Gene

Gene Tree for IZUMO4 (if available)
Gene Tree for IZUMO4 (if available)

Paralogs for IZUMO4 Gene

Selected SIMAP similar genes for IZUMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IZUMO4: view

No data available for Paralogs for IZUMO4 Gene

Variants for IZUMO4 Gene

Sequence variations from dbSNP and Humsavar for IZUMO4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1051767 -- 2,099,363(+) CTGCC(C/T)CAGGG utr-variant-3-prime
rs2240649 -- 2,099,110(+) ACCCT(G/T)CTGAC intron-variant
rs9967630 -- 2,099,821(+) AGAGC(A/G)CCTGG downstream-variant-500B
rs11542699 -- 2,098,997(+) TTCTC(C/T)TGGCC intron-variant, reference, synonymous-codon
rs11668148 -- 2,099,097(+) CCGCG(C/G)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO4 Gene

Variant ID Type Subtype PubMed ID
nsv910499 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3622n71 CNV Loss 21882294
dgv3624n71 CNV Loss 21882294
dgv3625n71 CNV Loss 21882294
dgv3626n71 CNV Loss 21882294
dgv3627n71 CNV Gain+Loss 21882294
nsv910619 CNV Loss 21882294
nsv910623 CNV Loss 21882294
nsv910624 CNV Gain 21882294
nsv910625 CNV Loss 21882294
nsv910626 CNV Loss 21882294
dgv3629n71 CNV Loss 21882294

Relevant External Links for IZUMO4 Gene

HapMap Linkage Disequilibrium report

Disorders for IZUMO4 Gene

No disorders were found for IZUMO4 Gene.

No data available for UniProtKB/Swiss-Prot for IZUMO4 Gene

Publications for IZUMO4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3
  4. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P. … Civetta A. (Int J Evol Biol 2012) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IZUMO4 Gene

Sources for IZUMO4 Gene

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