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Aliases for IZUMO4 Gene

Aliases for IZUMO4 Gene

  • IZUMO Family Member 4 2 3 5
  • Sperm 22 KDa Protein C113 3 4
  • C19orf36 3 4
  • Putative SAMP14 Binding Protein Variant 1 3
  • Putative SAMP14 Binding Protein Variant 2 3
  • Chromosome 19 Open Reading Frame 36 2
  • IMAGE:4215339 3

External Ids for IZUMO4 Gene

Previous HGNC Symbols for IZUMO4 Gene

  • C19orf36

Previous GeneCards Identifiers for IZUMO4 Gene

  • GC19P002085
  • GC19P001869

Summaries for IZUMO4 Gene

GeneCards Summary for IZUMO4 Gene

IZUMO4 (IZUMO Family Member 4) is a Protein Coding gene. Among its related pathways are Reproduction.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO4 Gene

Genomics for IZUMO4 Gene

Regulatory Elements for IZUMO4 Gene

Promoters for IZUMO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IZUMO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IZUMO4 Gene

Chromosome:
19
Start:
2,096,429 bp from pter
End:
2,099,593 bp from pter
Size:
3,165 bases
Orientation:
Plus strand

Genomic View for IZUMO4 Gene

Genes around IZUMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO4 Gene

Proteins for IZUMO4 Gene

  • Protein details for IZUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZYL8-IZUM4_HUMAN
    Recommended name:
    Izumo sperm-egg fusion protein 4
    Protein Accession:
    Q1ZYL8
    Secondary Accessions:
    • A7RA93
    • A7RA94
    • Q6UXA2
    • Q96FT6
    • Q96L02

    Protein attributes for IZUMO4 Gene

    Size:
    232 amino acids
    Molecular mass:
    26510 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Izumo is the name of a Japanese shrine to marriage.
    SequenceCaution:
    • Sequence=AAH10443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IZUMO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO4 Gene

Proteomics data for IZUMO4 Gene at MOPED

Post-translational modifications for IZUMO4 Gene

  • Glycosylation at Asn 24 and Asn 219

No data available for DME Specific Peptides for IZUMO4 Gene

Domains & Families for IZUMO4 Gene

Gene Families for IZUMO4 Gene

Protein Domains for IZUMO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1ZYL8

UniProtKB/Swiss-Prot:

IZUM4_HUMAN :
  • Belongs to the Izumo family.
Family:
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO4: view

Function for IZUMO4 Gene

Phenotypes for IZUMO4 Gene

GenomeRNAi human phenotypes for IZUMO4:
genes like me logo Genes that share phenotypes with IZUMO4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO4 Gene

Localization for IZUMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IZUMO4 Gene COMPARTMENTS Subcellular localization image for IZUMO4 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for IZUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IZUMO4: view

Pathways & Interactions for IZUMO4 Gene

SuperPathways for IZUMO4 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO4: view

Pathways by source for IZUMO4 Gene

3 Reactome pathways for IZUMO4 Gene

Interacting Proteins for IZUMO4 Gene

Gene Ontology (GO) - Biological Process for IZUMO4 Gene

None

No data available for SIGNOR curated interactions for IZUMO4 Gene

Drugs & Compounds for IZUMO4 Gene

No Compound Related Data Available

Transcripts for IZUMO4 Gene

Unigene Clusters for IZUMO4 Gene

IZUMO family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for IZUMO4 Gene

GeneLoc Exon Structure for
IZUMO4
ECgene alternative splicing isoforms for
IZUMO4

Expression for IZUMO4 Gene

mRNA expression in normal human tissues for IZUMO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO4 Gene

This gene is overexpressed in Testis (x24.5).

Protein differential expression in normal tissues from HIPED for IZUMO4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IZUMO4 Gene



SOURCE GeneReport for Unigene cluster for IZUMO4 Gene Hs.424049

mRNA Expression by UniProt/SwissProt for IZUMO4 Gene

Q1ZYL8-IZUM4_HUMAN
Tissue specificity: Detected in sperm.
genes like me logo Genes that share expression patterns with IZUMO4: view

Protein tissue co-expression partners for IZUMO4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IZUMO4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IZUMO4 35
  • 98.99 (n)
  • 97.84 (a)
IZUMO4 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IZUMO4 36
  • 84 (a)
OneToOne
IZUMO4 35
  • 86.58 (n)
  • 84.42 (a)
dog
(Canis familiaris)
Mammalia IZUMO4 35
  • 87 (n)
  • 86.24 (a)
IZUMO4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Izumo4 36
  • 76 (a)
OneToOne
Izumo4 16
Izumo4 35
  • 82.64 (n)
  • 78.8 (a)
rat
(Rattus norvegicus)
Mammalia Izumo4 35
  • 83.26 (n)
  • 80.18 (a)
Species with no ortholog for IZUMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO4 Gene

ENSEMBL:
Gene Tree for IZUMO4 (if available)
TreeFam:
Gene Tree for IZUMO4 (if available)

Paralogs for IZUMO4 Gene

(1) SIMAP similar genes for IZUMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IZUMO4: view

No data available for Paralogs for IZUMO4 Gene

Variants for IZUMO4 Gene

Sequence variations from dbSNP and Humsavar for IZUMO4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_030683 -
VAR_050911 -
VAR_061630 -
rs1051767 -- 2,099,363(+) CTGCC(C/T)CAGGG utr-variant-3-prime
rs2240649 -- 2,099,110(+) ACCCT(G/T)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO4 Gene

Variant ID Type Subtype PubMed ID
nsv910499 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3622n71 CNV Loss 21882294
dgv3624n71 CNV Loss 21882294
dgv3625n71 CNV Loss 21882294
dgv3626n71 CNV Loss 21882294
dgv3627n71 CNV Gain+Loss 21882294
nsv910619 CNV Loss 21882294
nsv910623 CNV Loss 21882294
nsv910624 CNV Gain 21882294
nsv910625 CNV Loss 21882294
nsv910626 CNV Loss 21882294
dgv3629n71 CNV Loss 21882294

Variation tolerance for IZUMO4 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IZUMO4 Gene

HapMap Linkage Disequilibrium report
IZUMO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO4 Gene

Disorders for IZUMO4 Gene

Relevant External Links for IZUMO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IZUMO4

No disorders were found for IZUMO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO4 Gene

Publications for IZUMO4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P. … Civetta A. (Int J Evol Biol 2012) 2 3
  3. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for IZUMO4 Gene

Sources for IZUMO4 Gene

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