IZUMO4 Gene
protein-coding GIFtS: 37
GCID: GC19P002085
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IZUMO family member 4(Previous name: chromosome 19 open reading frame 36 )
(Previous symbol: C19orf36)
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Aliases
for IZUMO4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IZUMO Family Member 41 2 | | IMAGE:42153392 | | C19orf361 2 3 | | Izumo Sperm-Egg Fusion Protein 42 | | Sperm 22 KDa Protein C1132 3 | | Putative SAMP14 Binding Protein Variant 12 | | Chromosome 19 Open Reading Frame 361 | | Putative SAMP14 Binding Protein Variant 22 |
Export aliases for IZUMO4 gene to outside databasesPrevious GC identifer: GC19P001869 |
Summaries
for IZUMO4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IZUMO4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IZUMO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IZUMO4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IZUMO4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3IZUMO4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002085: view genomic region
(about GC identifiers)
Start:
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2,096,380 bp from pter |
End:
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2,099,592 bp from pter |
Size:
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3,213 bases |
Orientation:
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plus strand |
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Proteins
for IZUMO4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8 (See
protein sequence)Recommended Name: Izumo sperm-egg fusion protein 4 precursor Size: 232 amino acids; 26510 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Izumo is the name of a Japanese shrine to marriage
Sequence caution: Sequence=AAH10443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7RA93 A7RA94 Q6UXA2 Q96FT6 Q96L02Alternative splicing: 4 isoforms: Q1ZYL8-1 Q1ZYL8-2 Q1ZYL8-3 Q1ZYL8-4 Explore the universe of human proteins at neXtProt for IZUMO4: NX_Q1ZYL8
IZUMO4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001026905.2 NP_001034935.1
ENSEMBL proteins: ENSP00000378718 ENSP00000378712 ENSP00000300960 ENSP00000378709
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
IZUMO4 for ontologies About GeneDecksing
IZUMO4 Antibody Products:
Assay Products for IZUMO4: |
Protein
Domains /
Families
for IZUMO4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q1ZYL8 UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8Similarity: Belongs to the Izumo family |
Function
for IZUMO4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IZUMO4 (NM_001031735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IZUMO4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO4 |
Animal Models:
Mouse knock-out Izumo4tm1Lex for IZUMO4
1 MGI phenotypic allele  for Izumo4 (no phenotypes)
IZUMO4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IZUMO4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IZUMO4
|
Drugs & Compounds
for IZUMO4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IZUMO4
Search CenterWatch for drugs/clinical trials and news about IZUMO4 / IZUM4
|
Transcripts
for IZUMO4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IZUMO4 gene (3 alternative transcripts): NM_052878.1 NM_001031735.2 NM_001039846.1 Unigene Cluster for IZUMO4: IZUMO family member 4 Hs.424049 [show with all ESTs]Unigene Representative Sequence: BC04096412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481489 ENST00000395307 ENST00000497445 ENST00000478879(uc002luw.1 uc010xgw.1)
ENST00000395301 ENST00000498554 ENST00000590985 ENST00000591894 ENST00000588003
ENST00000593185 ENST00000300960(uc002lux.1) ENST00000395296
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IZUMO4 (NM_001031735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IZUMO4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO4 |
Additional cDNA sequence: AK294083.1 AK301957.1 AY753639.1 BC014609.2 BC040964.1 DQ196309.1 DQ196310.1 DQ424900.1 11 DOTS entries: DT.423686 DT.86841481 DT.95182218 DT.100788170 DT.312897 DT.101982266 DT.100788169 DT.95182217 DT.121414692 DT.453508 DT.95182213 24/86 AceView cDNA sequences (see all 86): BI825218 BI825523 CD245930 BX378854 AY358444 NM_052878 CA396282 BI828436 AA789135 CD672070 BU623084 BX378853 BI826670 BC014609 BC010443 BM919396 CA389724 BI836649 BM563632 BI830254 BG719800 BI827887 BI826259 BI827131
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IZUMO4
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Expression
for IZUMO4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IZUMO4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGCTGAG
About this image
See IZUMO4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IZUMO4
SOURCE GeneReport for Unigene cluster: Hs.424049
UniProtKB/Swiss-Prot: IZUM4_HUMAN, Q1ZYL8Tissue specificity: Detected in sperm
SABiosciences Custom PCR Arrays for IZUMO4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IZUMO4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IZUMO4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IZUMO4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IZUMO4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO4 |
Orthologs
for IZUMO4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for IZUMO4 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for IZUMO4 (if available)
TreeFam Gene Tree for IZUMO4 (if available) |
Paralogs
for IZUMO4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IZUMO4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IZUMO4 (2096380 - 2099592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IZUMO4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IZUMO4 |
|
Disorders
/ Diseases
for IZUMO4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for IZUMO4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IZUMO4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IZUMO4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Positive Selection and the Evolution of izumo Genes in Mammals. (PubMed id 22957301)1, 3 Grayson P. and Civetta A. (2012)
- Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PubMed id 19658160)1, 3 Ellerman D.A....Primakoff P. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for IZUMO4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IZUMO4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IZUMO4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IZUMO4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IZUMO4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IZUMO4 gene:
Search GeneIP for patents involving IZUMO4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IZUMO4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IZUMO4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IZUMO4 | | | OriGene Protein Over-expression Lysate for IZUMO4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for IZUMO4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IZUMO4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IZUMO4 | | OriGene Custom Protein Services for IZUMO4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IZUMO4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IZUMO4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IZUMO4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IZUMO4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IZUMO4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IZUMO4 |
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 |  |  |  | |
| | | | Search Tocris compounds for IZUMO4 |
| |  |  |  |  | | | | |
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 | | | IZUMO4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO4 |
|  |  |  | | | | Search ThermoFisher Antibodies for IZUMO4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO4 |
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