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Aliases for IZUMO3 Gene

Aliases for IZUMO3 Gene

  • IZUMO Family Member 3 2 3
  • C9orf134 3 4
  • Chromosome 9 Open Reading Frame 134 2
  • Izumo Sperm-Egg Fusion Protein 3 3
  • BA20A20.1 3

External Ids for IZUMO3 Gene

Previous HGNC Symbols for IZUMO3 Gene

  • C9orf134

Previous GeneCards Identifiers for IZUMO3 Gene

  • GC09U901496

Summaries for IZUMO3 Gene

GeneCards Summary for IZUMO3 Gene

IZUMO3 (IZUMO Family Member 3) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include protein homodimerization activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO3 Gene

Genomics for IZUMO3 Gene

Genomic Location for IZUMO3 Gene

24,542,952 bp from pter
24,545,946 bp from pter
2,995 bases
Minus strand

Genomic View for IZUMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IZUMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO3 Gene

No data available for Regulatory Elements for IZUMO3 Gene

Proteins for IZUMO3 Gene

  • Protein details for IZUMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Izumo sperm-egg fusion protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IZUMO3 Gene

    239 amino acids
    Molecular mass:
    27768 Da
    Quaternary structure:
    • Monomer and homodimer.
    • Izumo is the name of a Japanese shrine to marriage
    • Sequence=CAH71315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IZUMO3 Gene

Proteomics data for IZUMO3 Gene at MOPED

Post-translational modifications for IZUMO3 Gene

  • Glycosylation at Asn96 and Asn126

Other Protein References for IZUMO3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IZUMO3 Gene

Domains for IZUMO3 Gene

Gene Families for IZUMO3 Gene

Protein Domains for IZUMO3 Gene


Suggested Antigen Peptide Sequences for IZUMO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Izumo family.
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO3: view

Function for IZUMO3 Gene

Gene Ontology (GO) - Molecular Function for IZUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with IZUMO3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO3 Gene

Localization for IZUMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IZUMO3 Gene COMPARTMENTS Subcellular localization image for IZUMO3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IZUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IZUMO3: view

Pathways for IZUMO3 Gene

SuperPathways for IZUMO3 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO3: view

Pathways by source for IZUMO3 Gene

3 Reactome pathways for IZUMO3 Gene

Interacting Proteins for IZUMO3 Gene

Gene Ontology (GO) - Biological Process for IZUMO3 Gene


Transcripts for IZUMO3 Gene

mRNA/cDNA for IZUMO3 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IZUMO3 Gene

IZUMO family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO3 Gene

No ASD Table

Relevant External Links for IZUMO3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IZUMO3 Gene

mRNA expression in normal human tissues for IZUMO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO3 Gene

This gene is overexpressed in Testis (53.0).

SOURCE GeneReport for Unigene cluster for IZUMO3 Gene Hs.573530

genes like me logo Genes that share expressions with IZUMO3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IZUMO3 Gene

Orthologs for IZUMO3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IZUMO3 35
  • 84.09 (n)
  • 75.91 (a)
  • 76 (a)
(Canis familiaris)
Mammalia IZUMO3 35
  • 86.21 (n)
  • 80.45 (a)
  • 80 (a)
(Mus musculus)
Mammalia Izumo3 35
  • 79.74 (n)
  • 72.25 (a)
Izumo3 16
Izumo3 36
  • 64 (a)
(Pan troglodytes)
Mammalia IZUMO3 35
  • 99.14 (n)
  • 98.71 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Izumo3 35
  • 78.55 (n)
  • 72.22 (a)
(Monodelphis domestica)
Mammalia IZUMO3 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia IZUMO3 36
  • 50 (a)
Species with no ortholog for IZUMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO3 Gene

Gene Tree for IZUMO3 (if available)
Gene Tree for IZUMO3 (if available)

Paralogs for IZUMO3 Gene

No data available for Paralogs for IZUMO3 Gene

Variants for IZUMO3 Gene

Sequence variations from dbSNP and Humsavar for IZUMO3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1329847 -- 24,543,550(+) TCCCA(A/G)AATTT intron-variant
rs2772577 -- 24,547,234(-) CATTC(C/T)ACTGT upstream-variant-2KB
rs2772578 -- 24,545,959(-) CATCT(C/G)CCTGC upstream-variant-2KB
rs2772579 -- 24,545,697(-) GTGAA(C/G)TAGTT upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs6475797 -- 24,545,515(+) CGGCC(A/G)GGGAC reference, synonymous-codon, intron-variant

Relevant External Links for IZUMO3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IZUMO3 Gene

Disorders for IZUMO3 Gene

No disorders were found for IZUMO3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IZUMO3 Gene

Publications for IZUMO3 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3
  3. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P. … Civetta A. (Int J Evol Biol 2012) 2 3

Products for IZUMO3 Gene

Sources for IZUMO3 Gene

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