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Aliases for IZUMO3 Gene

Aliases for IZUMO3 Gene

  • IZUMO Family Member 3 2 3 5
  • C9orf134 3 4
  • Chromosome 9 Open Reading Frame 134 2
  • Izumo Sperm-Egg Fusion Protein 3 3
  • BA20A20.1 3

External Ids for IZUMO3 Gene

Previous HGNC Symbols for IZUMO3 Gene

  • C9orf134

Previous GeneCards Identifiers for IZUMO3 Gene

  • GC09U901496

Summaries for IZUMO3 Gene

GeneCards Summary for IZUMO3 Gene

IZUMO3 (IZUMO Family Member 3) is a Protein Coding gene. Among its related pathways are Reproduction. GO annotations related to this gene include protein homodimerization activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO3 Gene

Genomics for IZUMO3 Gene

Regulatory Elements for IZUMO3 Gene

Enhancers for IZUMO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F024572 0.4 ENCODE 12.3 -26.7 -26657 1.1 SMARCA4 IZUMO3 GC09P024602 ENSG00000269957
GH09F024509 0.4 ENCODE 11.2 +35.9 35926 1.1 CBX3 IZUMO3 GC09P024502 LOC105375994
GH09F024479 0.2 ENCODE 11 +66.3 66265 1.2 IZUMO3 GC09P024502 PIR35899
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IZUMO3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IZUMO3 Gene

Chromosome:
9
Start:
24,542,952 bp from pter
End:
24,545,946 bp from pter
Size:
2,995 bases
Orientation:
Minus strand

Genomic View for IZUMO3 Gene

Genes around IZUMO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO3 Gene

Proteins for IZUMO3 Gene

  • Protein details for IZUMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ72-IZUM3_HUMAN
    Recommended name:
    Izumo sperm-egg fusion protein 3
    Protein Accession:
    Q5VZ72

    Protein attributes for IZUMO3 Gene

    Size:
    239 amino acids
    Molecular mass:
    27768 Da
    Quaternary structure:
    • Monomer and homodimer.
    Miscellaneous:
    • Izumo is the name of a Japanese shrine to marriage.
    SequenceCaution:
    • Sequence=CAH71315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IZUMO3 Gene

Post-translational modifications for IZUMO3 Gene

  • Glycosylation at Asn 96 and Asn 126

Other Protein References for IZUMO3 Gene

No data available for DME Specific Peptides for IZUMO3 Gene

Domains & Families for IZUMO3 Gene

Gene Families for IZUMO3 Gene

Protein Domains for IZUMO3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZ72

UniProtKB/Swiss-Prot:

IZUM3_HUMAN :
  • Belongs to the Izumo family.
Family:
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO3: view

Function for IZUMO3 Gene

Gene Ontology (GO) - Molecular Function for IZUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
GO:0042803 protein homodimerization activity IEA,ISS --
genes like me logo Genes that share ontologies with IZUMO3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO3 Gene

Localization for IZUMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IZUMO3 gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IZUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IZUMO3: view

Pathways & Interactions for IZUMO3 Gene

SuperPathways for IZUMO3 Gene

SuperPathway Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO3: view

Pathways by source for IZUMO3 Gene

3 Reactome pathways for IZUMO3 Gene

Interacting Proteins for IZUMO3 Gene

Gene Ontology (GO) - Biological Process for IZUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IZUMO3: view

No data available for SIGNOR curated interactions for IZUMO3 Gene

Transcripts for IZUMO3 Gene

mRNA/cDNA for IZUMO3 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IZUMO3 Gene

IZUMO family member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO3 Gene

No ASD Table

Relevant External Links for IZUMO3 Gene

GeneLoc Exon Structure for
IZUMO3
ECgene alternative splicing isoforms for
IZUMO3

Expression for IZUMO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IZUMO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO3 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of IZUMO3 Gene:

IZUMO3

SOURCE GeneReport for Unigene cluster for IZUMO3 Gene:

Hs.573530
genes like me logo Genes that share expression patterns with IZUMO3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IZUMO3 Gene

Orthologs for IZUMO3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IZUMO3 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia IZUMO3 34 35
  • 86.21 (n)
cow
(Bos Taurus)
Mammalia IZUMO3 34 35
  • 84.09 (n)
mouse
(Mus musculus)
Mammalia Izumo3 34 16 35
  • 79.74 (n)
rat
(Rattus norvegicus)
Mammalia Izumo3 34
  • 78.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IZUMO3 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IZUMO3 35
  • 45 (a)
OneToOne
Species where no ortholog for IZUMO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO3 Gene

ENSEMBL:
Gene Tree for IZUMO3 (if available)
TreeFam:
Gene Tree for IZUMO3 (if available)

Paralogs for IZUMO3 Gene

No data available for Paralogs for IZUMO3 Gene

Variants for IZUMO3 Gene

Sequence variations from dbSNP and Humsavar for IZUMO3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10812057 -- 24,543,479(+) CTGGA(A/T)ACTTC intron-variant
rs10812058 -- 24,543,593(+) AGGAA(A/G)AGGGA intron-variant, nc-transcript-variant
rs10966335 -- 24,543,323(+) ACCTT(C/T)GTATT intron-variant, reference, missense
rs10966336 -- 24,543,734(+) ATTCT(C/T)AGCCT downstream-variant-500B, reference, missense
rs10966337 -- 24,544,895(+) GAACT(C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO3 Gene

Variant ID Type Subtype PubMed ID
esv2752290 CNV gain 17911159
nsv1027072 CNV loss 25217958
nsv1032945 CNV loss 25217958
nsv831529 CNV loss 17160897

Variation tolerance for IZUMO3 Gene

Gene Damage Index Score: 2.97; 49.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IZUMO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IZUMO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO3 Gene

Disorders for IZUMO3 Gene

Relevant External Links for IZUMO3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IZUMO3

No disorders were found for IZUMO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO3 Gene

Publications for IZUMO3 Gene

  1. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P. … Civetta A. (Int J Evol Biol 2012) 2 3 64
  2. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for IZUMO3 Gene

Sources for IZUMO3 Gene

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