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Aliases for IZUMO2 Gene

Aliases for IZUMO2 Gene

  • IZUMO Family Member 2 2 3 5
  • C19orf41 3 4
  • SCRL 3 4
  • Chromosome 19 Open Reading Frame 41 2
  • Izumo Sperm-Egg Fusion Protein 2 3
  • PLAL6978 3
  • PRO21961 3

External Ids for IZUMO2 Gene

Previous HGNC Symbols for IZUMO2 Gene

  • C19orf41

Previous GeneCards Identifiers for IZUMO2 Gene

  • GC19M050656
  • GC19M046995

Summaries for IZUMO2 Gene

GeneCards Summary for IZUMO2 Gene

IZUMO2 (IZUMO Family Member 2) is a Protein Coding gene. Among its related pathways are Reproduction.

Additional gene information for IZUMO2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO2 Gene

Genomics for IZUMO2 Gene

Regulatory Elements for IZUMO2 Gene

Enhancers for IZUMO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050264 0.8 FANTOM5 1.8 -101.3 -101312 0 CTCF ATF1 RB1 TAL1 RAD21 TCF12 CC2D1A MTA3 POLR2A NCOR1 KLK12 IZUMO2 PIR48748 GC19P050308
GH19H050165 0.7 ENCODE 0.7 -2.3 -2318 0 CTCF ZNF654 REST KLF4 RAD21 ZNF217 ZFHX2 EGR1 GLIS1 SMC3 IZUMO2 MYH14
GH19H050172 1.1 ENCODE dbSUPER 0.4 -9.9 -9943 1 HDAC1 TBP KLF17 RFX5 ZNF121 GATA2 ELK1 RCOR1 ATF7 ZNF280D IZUMO2 MYH14
GH19H050178 1.1 ENCODE dbSUPER 0.4 -15.8 -15785 1 ZBTB40 ZNF366 SCRT2 KLF7 ATF7 ZNF391 IKZF2 CREM EGR2 SP3 MYH14 IZUMO2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IZUMO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IZUMO2 Gene

50,152,548 bp from pter
50,163,281 bp from pter
10,734 bases
Minus strand

Genomic View for IZUMO2 Gene

Genes around IZUMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO2 Gene

Proteins for IZUMO2 Gene

  • Protein details for IZUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Izumo sperm-egg fusion protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5GRG3
    • Q5GRG4
    • Q6ZNM5
    • Q8NHR8

    Protein attributes for IZUMO2 Gene

    221 amino acids
    Molecular mass:
    24856 Da
    Quaternary structure:
    No Data Available
    • Izumo is the name of a Japanese shrine to marriage.
    • Sequence=AAQ05826.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAQ05827.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for IZUMO2 Gene


neXtProt entry for IZUMO2 Gene

Post-translational modifications for IZUMO2 Gene

  • Glycosylation at isoforms=291
  • Modification sites at PhosphoSitePlus

Other Protein References for IZUMO2 Gene

No data available for DME Specific Peptides for IZUMO2 Gene

Domains & Families for IZUMO2 Gene

Gene Families for IZUMO2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for IZUMO2 Gene


Suggested Antigen Peptide Sequences for IZUMO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Izumo family.
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO2: view

Function for IZUMO2 Gene

genes like me logo Genes that share phenotypes with IZUMO2: view

Animal Model Products

CRISPR Products

miRNA for IZUMO2 Gene

miRTarBase miRNAs that target IZUMO2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IZUMO2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IZUMO2 Gene

Localization for IZUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IZUMO2 gene
Compartment Confidence
plasma membrane 3
nucleus 3
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IZUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IZUMO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IZUMO2 Gene

Pathways & Interactions for IZUMO2 Gene

SuperPathways for IZUMO2 Gene

SuperPathway Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO2: view

Pathways by source for IZUMO2 Gene

3 Reactome pathways for IZUMO2 Gene

Interacting Proteins for IZUMO2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000293405 for IZUMO2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IZUMO2 Gene


No data available for SIGNOR curated interactions for IZUMO2 Gene

Drugs & Compounds for IZUMO2 Gene

No Compound Related Data Available

Transcripts for IZUMO2 Gene

mRNA/cDNA for IZUMO2 Gene

Unigene Clusters for IZUMO2 Gene

IZUMO family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IZUMO2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO2 Gene

No ASD Table

Relevant External Links for IZUMO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IZUMO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IZUMO2 Gene

mRNA differential expression in normal tissues according to GTEx for IZUMO2 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for IZUMO2 Gene

This gene is overexpressed in Stomach (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IZUMO2 Gene

Protein tissue co-expression partners for IZUMO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IZUMO2 Gene:


SOURCE GeneReport for Unigene cluster for IZUMO2 Gene:

genes like me logo Genes that share expression patterns with IZUMO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IZUMO2 Gene

Orthologs for IZUMO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IZUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IZUMO2 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia IZUMO2 33 34
  • 81.21 (n)
(Mus musculus)
Mammalia Izumo2 34
  • 60 (a)
(Bos Taurus)
Mammalia C18H19ORF41 34
  • 47 (a)
(Anolis carolinensis)
Reptilia IZUMO2 34
  • 34 (a)
Species where no ortholog for IZUMO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO2 Gene

Gene Tree for IZUMO2 (if available)
Gene Tree for IZUMO2 (if available)

Paralogs for IZUMO2 Gene

(3) SIMAP similar genes for IZUMO2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IZUMO2: view

No data available for Paralogs for IZUMO2 Gene

Variants for IZUMO2 Gene

Sequence variations from dbSNP and Humsavar for IZUMO2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000234823 -- 50,163,190(+) CCAGA(A/G)GCATG nc-transcript-variant, reference, missense
rs1000291839 -- 50,156,871(+) TTGAA(C/T)AAATC intron-variant
rs1000349301 -- 50,160,544(+) ATGGC(A/G)TGATC intron-variant, nc-transcript-variant
rs1000524192 -- 50,154,421(+) GTACG(A/G)GGCAG intron-variant
rs1000992310 -- 50,160,784(+) TGCTA(A/C)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO2 Gene

Variant ID Type Subtype PubMed ID
esv2658287 CNV deletion 23128226
esv2751796 CNV gain 17911159
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv2526 CNV insertion 18451855
nsv428369 CNV loss 18775914

Variation tolerance for IZUMO2 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IZUMO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO2 Gene

Disorders for IZUMO2 Gene

Relevant External Links for IZUMO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IZUMO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO2 Gene

Publications for IZUMO2 Gene

  1. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P … Civetta A (International journal of evolutionary biology 2012) 2 3 60
  2. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman DA … Primakoff P (Molecular reproduction and development 2009) 2 3 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for IZUMO2 Gene

Sources for IZUMO2 Gene

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