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Aliases for IZUMO2 Gene

Aliases for IZUMO2 Gene

  • IZUMO Family Member 2 2 3
  • C19orf41 3 4
  • SCRL 3 4
  • Chromosome 19 Open Reading Frame 41 2
  • Izumo Sperm-Egg Fusion Protein 2 3
  • PLAL6978 3
  • PRO21961 3

External Ids for IZUMO2 Gene

Previous Symbols for IZUMO2 Gene

  • C19orf41

Summaries for IZUMO2 Gene

GeneCards Summary for IZUMO2 Gene

IZUMO2 (IZUMO Family Member 2) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO2 Gene

Genomics for IZUMO2 Gene

Genomic Location for IZUMO2 Gene

50,152,548 bp from pter
50,163,281 bp from pter
10,734 bases
Minus strand

Genomic View for IZUMO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IZUMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO2 Gene

No data available for Regulatory Elements for IZUMO2 Gene

Proteins for IZUMO2 Gene

  • Protein details for IZUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Izumo sperm-egg fusion protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5GRG3
    • Q5GRG4
    • Q6ZNM5
    • Q8NHR8

    Protein attributes for IZUMO2 Gene

    221 amino acids
    Molecular mass:
    24856 Da
    Quaternary structure:
    No Data Available
    • Izumo is the name of a Japanese shrine to marriage
    • Sequence=AAQ05826.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAQ05827.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for IZUMO2 Gene


neXtProt entry for IZUMO2 Gene

Proteomics data for IZUMO2 Gene at MOPED

Post-translational modifications for IZUMO2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn91

Other Protein References for IZUMO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IZUMO2 Gene

Domains for IZUMO2 Gene

Protein Domains for IZUMO2 Gene



  • Belongs to the Izumo family.:
    • Q6UXV1
genes like me logo Genes that share domains with IZUMO2: view

No data available for Gene Families for IZUMO2 Gene

Function for IZUMO2 Gene

miRNA for IZUMO2 Gene

miRTarBase miRNAs that target IZUMO2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IZUMO2 Gene

Localization for IZUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IZUMO2 Gene COMPARTMENTS Subcellular localization image for IZUMO2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IZUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IZUMO2: view

Pathways for IZUMO2 Gene

SuperPathways for IZUMO2 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO2: view

Pathways by source for IZUMO2 Gene

3 Reactome pathways for IZUMO2 Gene

Interacting Proteins for IZUMO2 Gene

Gene Ontology (GO) - Biological Process for IZUMO2 Gene


Transcripts for IZUMO2 Gene

mRNA/cDNA for IZUMO2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IZUMO2 Gene

IZUMO family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO2 Gene

No ASD Table

Relevant External Links for IZUMO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IZUMO2 Gene

mRNA expression in normal human tissues for IZUMO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO2 Gene

This gene is overexpressed in Testis (51.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IZUMO2 Gene

SOURCE GeneReport for Unigene cluster for IZUMO2 Gene Hs.414175

genes like me logo Genes that share expressions with IZUMO2: view

Orthologs for IZUMO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IZUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IZUMO2 36
  • 99.7 (n)
  • 99.55 (a)
  • 100 (a)
(Bos Taurus)
Mammalia C18H19ORF41 37
  • 47 (a)
(Canis familiaris)
Mammalia IZUMO2 36
  • 81.21 (n)
  • 70 (a)
  • 69 (a)
(Mus musculus)
Mammalia Izumo2 16
Izumo2 37
  • 60 (a)
(Anolis carolinensis)
Reptilia IZUMO2 37
  • 34 (a)
Species with no ortholog for IZUMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO2 Gene

Gene Tree for IZUMO2 (if available)
Gene Tree for IZUMO2 (if available)

Paralogs for IZUMO2 Gene

Selected SIMAP similar genes for IZUMO2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IZUMO2: view

No data available for Paralogs for IZUMO2 Gene

Variants for IZUMO2 Gene

Sequence variations from dbSNP and Humsavar for IZUMO2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs658644 -- 50,164,247(+) tcacc(C/T)gcctc upstream-variant-2KB
rs921934 -- 50,164,193(+) acggg(G/T)tttca upstream-variant-2KB
rs1290836 -- 50,154,272(-) aaaaa(A/C)aaaaa intron-variant
rs1290837 -- 50,154,247(-) tattt(G/T)gtgga intron-variant
rs1296504 -- 50,154,280(-) aaaaa(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO2 Gene

Variant ID Type Subtype PubMed ID
esv2751796 CNV Gain 17911159
nsv428369 CNV Loss 18775914
dgv3975n71 CNV Gain 21882294
nsv2526 CNV Insertion 18451855
esv2658287 CNV Deletion 23128226

Relevant External Links for IZUMO2 Gene

HapMap Linkage Disequilibrium report

Disorders for IZUMO2 Gene

No disorders were found for IZUMO2 Gene.

No data available for UniProtKB/Swiss-Prot for IZUMO2 Gene

Publications for IZUMO2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3
  3. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P. … Civetta A. (Int J Evol Biol 2012) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for IZUMO2 Gene

Sources for IZUMO2 Gene

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