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Aliases for IZUMO1R Gene

Aliases for IZUMO1R Gene

  • IZUMO1 Receptor, JUNO 2 3 5
  • Folate Receptor 4, Delta (Putative) 2 3
  • IZUMO1 Receptor Protein JUNO 3 4
  • Folate Receptor Delta 3 4
  • FR-Delta 3 4
  • FOLR4 3 4
  • JUNO 3 4
  • Folate Receptor 4 (Delta) Homolog (Mouse) 2
  • Folate Receptor 4 (Delta) Homolog 3
  • Probable Folate Receptor Delta 3
  • Sperm-Egg Fusion Protein Juno 3
  • Folate Receptor 4 4
  • Folbp3 3

External Ids for IZUMO1R Gene

Previous HGNC Symbols for IZUMO1R Gene

  • FOLR4

Summaries for IZUMO1R Gene

GeneCards Summary for IZUMO1R Gene

IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Folate Metabolism. GO annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR1.

UniProtKB/Swiss-Prot for IZUMO1R Gene

  • Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen. Does not bind folate.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO1R Gene

Genomics for IZUMO1R Gene

Regulatory Elements for IZUMO1R Gene

Enhancers for IZUMO1R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G094303 0.8 Ensembl ENCODE 0.7 -0.3 -273 2.2 CTCF MNT REST RAD21 GPR83 MRE11 ENSG00000255893 LOC105369435 IZUMO1R GC11P094202
GH11G094325 0.6 ENCODE 0.3 +21.3 21309 0.2 CTCF MAZ TRIM22 CEBPB CEBPG REST RAD21 SMC3 THAP11 IZUMO1R GC11M094380 GC11M094381
GH11G094237 0.9 ENCODE 0.2 -66.7 -66732 0.1 ZNF473 ZNF195 BRCA1 GLIS2 HSF1 ZNF416 ZNF350 MCM3 ZNF114 YY2 MED17 BUD13P1 ANKRD49 ENSG00000270578 MRE11 SNORA1 FUT4 GC11P094202 IZUMO1R
GH11G094310 0.4 FANTOM5 0.4 +5.5 5538 0.0 ZBTB17 IZUMO1R GC11M094380 GC11M094381
GH11G094238 0.8 ENCODE 0.2 -66.6 -66562 0.1 CTCF KLF1 FOXA2 ZNF792 ZNF704 ZIC2 GLIS2 ZNF157 ZBTB48 HSF1 MED17 MRE11 ANKRD49 SNORA1 BUD13P1 FUT4 GC11P094202 IZUMO1R
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IZUMO1R on UCSC Golden Path with GeneCards custom track

Genomic Location for IZUMO1R Gene

Chromosome:
11
Start:
94,304,561 bp from pter
End:
94,307,762 bp from pter
Size:
3,202 bases
Orientation:
Plus strand

Genomic View for IZUMO1R Gene

Genes around IZUMO1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO1R Gene

Proteins for IZUMO1R Gene

  • Protein details for IZUMO1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND01-JUNO_HUMAN
    Recommended name:
    Sperm-egg fusion protein Juno
    Protein Accession:
    A6ND01

    Protein attributes for IZUMO1R Gene

    Size:
    250 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Monomer (PubMed:27309808). Interacts with IZUMO1; the interaction is direct. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:24739963, PubMed:27309818, PubMed:27309808).

    Three dimensional structures from OCA and Proteopedia for IZUMO1R Gene

    Alternative splice isoforms for IZUMO1R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO1R Gene

Post-translational modifications for IZUMO1R Gene

  • The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.
  • Glycosylation at isoforms=273

Other Protein References for IZUMO1R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IZUMO1R Gene

Domains & Families for IZUMO1R Gene

Gene Families for IZUMO1R Gene

Protein Domains for IZUMO1R Gene

Suggested Antigen Peptide Sequences for IZUMO1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6ND01

UniProtKB/Swiss-Prot:

JUNO_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with IZUMO1R: view

Function for IZUMO1R Gene

Molecular function for IZUMO1R Gene

UniProtKB/Swiss-Prot Function:
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen. Does not bind folate.

Gene Ontology (GO) - Molecular Function for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IPI 24739963
GO:0005515 protein binding IPI 24739963
GO:0005542 NOT folic acid binding ISS --
genes like me logo Genes that share ontologies with IZUMO1R: view
genes like me logo Genes that share phenotypes with IZUMO1R: view

Animal Models for IZUMO1R Gene

MGI Knock Outs for IZUMO1R:

Animal Model Products

  • Taconic Biosciences Mouse Models for IZUMO1R

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO1R Gene

Localization for IZUMO1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO1R Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=GPI-anchored at the oolemma. {ECO:0000250 UniProtKB:Q9EQF4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IZUMO1R gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with IZUMO1R: view

Pathways & Interactions for IZUMO1R Gene

genes like me logo Genes that share pathways with IZUMO1R: view

Pathways by source for IZUMO1R Gene

Interacting Proteins for IZUMO1R Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000416935%0d%0a9606.ENSP00000298223%0d%0a9606.ENSP00000308137%0d%0a9606.ENSP00000327786%0d%0a
Selected Interacting proteins: ENSP00000416935 A6ND01-JUNO_HUMAN for IZUMO1R Gene via STRING IID

Gene Ontology (GO) - Biological Process for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007155 cell adhesion ISS --
GO:0007338 single fertilization ISS --
GO:0007342 fusion of sperm to egg plasma membrane ISS --
GO:0035036 sperm-egg recognition ISS --
genes like me logo Genes that share ontologies with IZUMO1R: view

No data available for SIGNOR curated interactions for IZUMO1R Gene

Drugs & Compounds for IZUMO1R Gene

(1) Drugs for IZUMO1R Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved, Vet_approved Nutra 4392
genes like me logo Genes that share compounds with IZUMO1R: view

Transcripts for IZUMO1R Gene

mRNA/cDNA for IZUMO1R Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO1R Gene

No ASD Table

Relevant External Links for IZUMO1R Gene

GeneLoc Exon Structure for
IZUMO1R
ECgene alternative splicing isoforms for
IZUMO1R

Expression for IZUMO1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IZUMO1R Gene

NURSA nuclear receptor signaling pathways regulating expression of IZUMO1R Gene:

IZUMO1R
genes like me logo Genes that share expression patterns with IZUMO1R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IZUMO1R Gene

Orthologs for IZUMO1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IZUMO1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR4 35 34
  • 99.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Folr4 34
  • 78.06 (n)
mouse
(Mus musculus)
Mammalia Folr4 35 34
  • 77.87 (n)
OneToOne
Izumo1r 16
oppossum
(Monodelphis domestica)
Mammalia FOLR4 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOLR4 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for IZUMO1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IZUMO1R Gene

ENSEMBL:
Gene Tree for IZUMO1R (if available)
TreeFam:
Gene Tree for IZUMO1R (if available)

Paralogs for IZUMO1R Gene

Paralogs for IZUMO1R Gene

genes like me logo Genes that share paralogs with IZUMO1R: view

Variants for IZUMO1R Gene

Sequence variations from dbSNP and Humsavar for IZUMO1R Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000008389 -- 94,307,016(+) TCTTA(A/G)CCTCA intron-variant
rs1000679709 -- 94,307,836(+) CATGC(A/C)ACTGC downstream-variant-500B
rs1000682192 -- 94,305,978(+) CTCTA(A/G)CCACT intron-variant
rs1001134329 -- 94,307,396(+) GGAGG(G/T)AAGCT intron-variant
rs1001220646 -- 94,305,769(+) TCTAT(A/G)AGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IZUMO1R Gene

Variant ID Type Subtype PubMed ID
esv3627315 CNV gain 21293372
esv3627317 CNV gain 21293372
esv3892069 CNV loss 25118596
esv3892072 CNV gain 25118596
esv3892073 CNV loss 25118596
nsv523083 CNV gain 19592680
nsv832233 CNV gain 17160897

Variation tolerance for IZUMO1R Gene

Gene Damage Index Score: 5.15; 69.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IZUMO1R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IZUMO1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO1R Gene

Disorders for IZUMO1R Gene

Relevant External Links for IZUMO1R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IZUMO1R

No disorders were found for IZUMO1R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO1R Gene

Publications for IZUMO1R Gene

  1. Juno is the egg Izumo receptor and is essential for mammalian fertilization. (PMID: 24739963) Bianchi E. … Wright G.J. (Nature 2014) 2 3 4 64
  2. Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. (PMID: 27309818) Aydin H. … Lee J.E. (Nature 2016) 3 4 64
  3. Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. (PMID: 27309808) Ohto U. … Shimizu T. (Nature 2016) 3 4 64
  4. Identification of two putative novel folate receptor genes in humans and mouse. (PMID: 11111049) Spiegelstein O. … Finnell R.H. (Gene 2000) 2 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for IZUMO1R Gene

Sources for IZUMO1R Gene

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