Aliases for IZUMO1R Gene
External Ids for IZUMO1R Gene
Previous HGNC Symbols for IZUMO1R Gene
GeneCards Summary for IZUMO1R Gene
IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Antifolate resistance and Endocytosis. GO annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR1.
UniProtKB/Swiss-Prot for IZUMO1R Gene
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen. Does not bind folate.