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Aliases for IZUMO1R Gene

Aliases for IZUMO1R Gene

  • IZUMO1 Receptor, JUNO 2 3 5
  • Folate Receptor 4, Delta (Putative) 2 3
  • IZUMO1 Receptor Protein JUNO 3 4
  • Folate Receptor Delta 3 4
  • FR-Delta 3 4
  • FOLR4 3 4
  • JUNO 3 4
  • Folate Receptor 4 (Delta) Homolog (Mouse) 2
  • Folate Receptor 4 (Delta) Homolog 3
  • Probable Folate Receptor Delta 3
  • Folate Receptor 4 4
  • Folbp3 3

External Ids for IZUMO1R Gene

Previous HGNC Symbols for IZUMO1R Gene

  • FOLR4

Summaries for IZUMO1R Gene

GeneCards Summary for IZUMO1R Gene

IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR3.

UniProtKB/Swiss-Prot for IZUMO1R Gene

  • Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen. Does not bind folate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO1R Gene

Genomics for IZUMO1R Gene

Regulatory Elements for IZUMO1R Gene

Enhancers for IZUMO1R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IZUMO1R on UCSC Golden Path with GeneCards custom track

Genomic Location for IZUMO1R Gene

Chromosome:
11
Start:
94,304,561 bp from pter
End:
94,307,762 bp from pter
Size:
3,202 bases
Orientation:
Plus strand

Genomic View for IZUMO1R Gene

Genes around IZUMO1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO1R Gene

Proteins for IZUMO1R Gene

  • Protein details for IZUMO1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND01-JUNO_HUMAN
    Recommended name:
    Sperm-egg fusion protein Juno
    Protein Accession:
    A6ND01

    Protein attributes for IZUMO1R Gene

    Size:
    250 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with IZUMO1; the interaction is direct.

    Alternative splice isoforms for IZUMO1R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO1R Gene

Proteomics data for IZUMO1R Gene at MOPED

Post-translational modifications for IZUMO1R Gene

  • The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm (By similarity).
  • Glycosylation at Asn 73

Other Protein References for IZUMO1R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IZUMO1R Gene

Domains & Families for IZUMO1R Gene

Protein Domains for IZUMO1R Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6ND01

UniProtKB/Swiss-Prot:

JUNO_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with IZUMO1R: view

No data available for Gene Families for IZUMO1R Gene

Function for IZUMO1R Gene

Molecular function for IZUMO1R Gene

UniProtKB/Swiss-Prot Function:
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen. Does not bind folate (By similarity).
genes like me logo Genes that share phenotypes with IZUMO1R: view

Animal Models for IZUMO1R Gene

MGI Knock Outs for IZUMO1R:

Animal Model Products

  • Taconic Biosciences Mouse Models for IZUMO1R

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO1R Gene

Localization for IZUMO1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO1R Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=GPI-anchored at the oolemma. {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IZUMO1R Gene

Pathways & Interactions for IZUMO1R Gene

SuperPathways for IZUMO1R Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with IZUMO1R: view

Pathways by source for IZUMO1R Gene

1 KEGG pathway for IZUMO1R Gene

Interacting Proteins for IZUMO1R Gene

Gene Ontology (GO) - Biological Process for IZUMO1R Gene

None

No data available for SIGNOR curated interactions for IZUMO1R Gene

Drugs & Compounds for IZUMO1R Gene

(1) Drugs for IZUMO1R Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved Nutra 4079
genes like me logo Genes that share compounds with IZUMO1R: view

Transcripts for IZUMO1R Gene

mRNA/cDNA for IZUMO1R Gene

(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO1R Gene

No ASD Table

Relevant External Links for IZUMO1R Gene

GeneLoc Exon Structure for
IZUMO1R
ECgene alternative splicing isoforms for
IZUMO1R

Expression for IZUMO1R Gene

mRNA expression in normal human tissues for IZUMO1R Gene

genes like me logo Genes that share expression patterns with IZUMO1R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IZUMO1R Gene

Orthologs for IZUMO1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IZUMO1R Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Folr4 35
  • 77.87 (n)
  • 68.88 (a)
Izumo1r 16
Folr4 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOLR4 35
  • 99.73 (n)
  • 99.6 (a)
FOLR4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Folr4 35
  • 78.06 (n)
  • 70.83 (a)
dog
(Canis familiaris)
Mammalia FOLR4 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOLR4 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for IZUMO1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IZUMO1R Gene

ENSEMBL:
Gene Tree for IZUMO1R (if available)
TreeFam:
Gene Tree for IZUMO1R (if available)

Paralogs for IZUMO1R Gene

Paralogs for IZUMO1R Gene

genes like me logo Genes that share paralogs with IZUMO1R: view

Variants for IZUMO1R Gene

Sequence variations from dbSNP and Humsavar for IZUMO1R Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs522504 -- 94,304,744(-) CTCCA(C/T)GTGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs569781 -- 94,306,990(-) CCTGG(A/G)CTATA intron-variant
rs577062 -- 94,303,128(+) ACCCT(A/G)TGAAG upstream-variant-2KB
rs577124 -- 94,303,155(+) CCTAT(A/T)TCCAT upstream-variant-2KB
rs628994 -- 94,305,143(-) CCCCA(A/G)GTCTG intron-variant, upstream-variant-2KB

Variation tolerance for IZUMO1R Gene

Gene Damage Index Score: 5.15; 69.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for IZUMO1R Gene

Disorders for IZUMO1R Gene

Relevant External Links for IZUMO1R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IZUMO1R

No disorders were found for IZUMO1R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO1R Gene

Publications for IZUMO1R Gene

  1. Juno is the egg Izumo receptor and is essential for mammalian fertilization. (PMID: 24739963) Bianchi E. … Wright G.J. (Nature 2014) 2 3 4 67
  2. Identification of two putative novel folate receptor genes in humans and mouse. (PMID: 11111049) Spiegelstein O. … Finnell R.H. (Gene 2000) 2 3

Products for IZUMO1R Gene

Sources for IZUMO1R Gene

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