Aliases for IZUMO1 Gene
External Ids for IZUMO1 Gene
Previous GeneCards Identifiers for IZUMO1 Gene
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
GeneCards Summary for IZUMO1 Gene
IZUMO1 (Izumo Sperm-Egg Fusion 1) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include protein homodimerization activity.
UniProtKB/Swiss-Prot for IZUMO1 Gene
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen.