Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IZUMO1 Gene

Aliases for IZUMO1 Gene

  • Izumo Sperm-Egg Fusion 1 2 3
  • Oocyte Binding/Fusion Factor 2 3 4
  • Sperm-Specific Protein Izumo 3 4
  • OBF 3 4
  • Izumo Sperm-Egg Fusion Protein 1 3
  • MGC34799 6
  • IZUMO 3

External Ids for IZUMO1 Gene

Previous GeneCards Identifiers for IZUMO1 Gene

  • GC19M053939
  • GC19M049244
  • GC19M045623

Summaries for IZUMO1 Gene

Entrez Gene Summary for IZUMO1 Gene

  • The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IZUMO1 Gene

IZUMO1 (Izumo Sperm-Egg Fusion 1) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for IZUMO1 Gene

  • Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IZUMO1 Gene

Genomics for IZUMO1 Gene

Regulatory Elements for IZUMO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IZUMO1 Gene

Start:
48,740,852 bp from pter
End:
48,747,574 bp from pter
Size:
6,723 bases
Orientation:
Minus strand

Genomic View for IZUMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IZUMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO1 Gene

Proteins for IZUMO1 Gene

  • Protein details for IZUMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYV9-IZUM1_HUMAN
    Recommended name:
    Izumo sperm-egg fusion protein 1
    Protein Accession:
    Q8IYV9
    Secondary Accessions:
    • Q6Q8P6
    • Q6Q8P7

    Protein attributes for IZUMO1 Gene

    Size:
    350 amino acids
    Molecular mass:
    38930 Da
    Quaternary structure:
    • Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity).
    Miscellaneous:
    • Izumo is the name of a Japanese shrine to marriage

    Alternative splice isoforms for IZUMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO1 Gene

Proteomics data for IZUMO1 Gene at MOPED

Post-translational modifications for IZUMO1 Gene

Other Protein References for IZUMO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IZUMO1 Gene

Domains for IZUMO1 Gene

Protein Domains for IZUMO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYV9

UniProtKB/Swiss-Prot:

IZUM1_HUMAN :
  • Q8IYV9
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO1: view

No data available for Gene Families for IZUMO1 Gene

Function for IZUMO1 Gene

Molecular function for IZUMO1 Gene

UniProtKB/Swiss-Prot Function:
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen.

Gene Ontology (GO) - Molecular Function for IZUMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 24739963
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with IZUMO1: view

Phenotypes for IZUMO1 Gene

MGI mutant phenotypes for IZUMO1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with IZUMO1: view

Animal Models for IZUMO1 Gene

MGI Knock Outs for IZUMO1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IZUMO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IZUMO1 Gene

Localization for IZUMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IZUMO1 Gene COMPARTMENTS Subcellular localization image for IZUMO1 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IZUMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle --
GO:0002080 acrosomal membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 15759005
genes like me logo Genes that share ontologies with IZUMO1: view

Pathways for IZUMO1 Gene

SuperPathways for IZUMO1 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with IZUMO1: view

Pathways by source for IZUMO1 Gene

3 Reactome pathways for IZUMO1 Gene

Interacting Proteins for IZUMO1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327786%0d%0a9606.ENSP00000009180%0d%0a
Selected Interacting proteins: ENSP00000327786 for IZUMO1 Gene via STRING

Symbol External ID(s) Details
CD9

Gene Ontology (GO) - Biological Process for IZUMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IC 15759005
GO:0007338 single fertilization TAS --
GO:0007342 fusion of sperm to egg plasma membrane TAS --
GO:0032504 multicellular organism reproduction TAS --
GO:0035036 sperm-egg recognition ISS --
genes like me logo Genes that share ontologies with IZUMO1: view

Transcripts for IZUMO1 Gene

Unigene Clusters for IZUMO1 Gene

Izumo sperm-egg fusion 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IZUMO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for IZUMO1 Gene

GeneLoc Exon Structure for
IZUMO1
ECgene alternative splicing isoforms for
IZUMO1

Expression for IZUMO1 Gene

mRNA expression in normal human tissues for IZUMO1 Gene

mRNA differential expression in normal tissues according to GTEx for IZUMO1 Gene

This gene is overexpressed in Testis (24.3), Pancreas (7.4), and Stomach (4.5).

SOURCE GeneReport for Unigene cluster for IZUMO1 Gene Hs.400688

mRNA Expression by UniProt/SwissProt for IZUMO1 Gene

Q8IYV9-IZUM1_HUMAN
Tissue specificity: Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
genes like me logo Genes that share expressions with IZUMO1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for IZUMO1 Gene

Orthologs for IZUMO1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IZUMO1 35
  • 77.38 (n)
  • 67.87 (a)
IZUMO1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Izumo1 35
  • 65.13 (n)
  • 54.77 (a)
Izumo1 16
Izumo1 36
  • 44 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IZUMO1 35
  • 99.24 (n)
  • 99.14 (a)
IZUMO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Izumo1 35
  • 69.35 (n)
  • 62.99 (a)
dog
(Canis familiaris)
Mammalia IZUMO1 36
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IZUMO1 36
  • 31 (a)
OneToOne
Species with no ortholog for IZUMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IZUMO1 Gene

ENSEMBL:
Gene Tree for IZUMO1 (if available)
TreeFam:
Gene Tree for IZUMO1 (if available)

Paralogs for IZUMO1 Gene

No data available for Paralogs for IZUMO1 Gene

Variants for IZUMO1 Gene

Sequence variations from dbSNP and Humsavar for IZUMO1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs838144 -- 48,746,982(-) GCGAT(A/G)GGCGG upstream-variant-2KB, intron-variant
rs838145 -- 48,745,473(-) AATAC(C/T)GTTTT intron-variant
rs838146 -- 48,744,795(-) GCGGG(A/G)GGATT intron-variant
rs838147 -- 48,743,609(-) GATGA(C/T)CTGGC intron-variant
rs838148 -- 48,743,121(-) tggac(C/T)cagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3967n71 CNV Loss 21882294
nsv912238 CNV Gain 21882294
dgv3968n71 CNV Loss 21882294
nsv912242 CNV Loss 21882294
nsv912244 CNV Gain 21882294

Relevant External Links for IZUMO1 Gene

HapMap Linkage Disequilibrium report
IZUMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO1 Gene

Disorders for IZUMO1 Gene

Relevant External Links for IZUMO1

Genetic Association Database (GAD)
IZUMO1
Human Genome Epidemiology (HuGE) Navigator
IZUMO1

No disorders were found for IZUMO1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IZUMO1 Gene

Publications for IZUMO1 Gene

  1. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. (PMID: 15759005) Inoue N. … Okabe M. (Nature 2005) 2 3 4 23
  2. Preliminary study on the role of the human IZUMO gene in oocyte- spermatozoa fusion failure. (PMID: 18082733) Granados-Gonzalez V. … Levy R. (Fertil. Steril. 2008) 3 4 48
  3. Putative sperm fusion protein IZUMO and the role of N-glycosylation. (PMID: 18952059) Inoue N. … Okabe M. (Biochem. Biophys. Res. Commun. 2008) 2 3
  4. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman D.A. … Primakoff P. (Mol. Reprod. Dev. 2009) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IZUMO1 Gene

Sources for IZUMO1 Gene

Back to Top

Content