Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IZUMO1 Gene

protein-coding   GIFtS: 50
GCID: GC19M049244

Izumo Sperm-Egg Fusion 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Izumo Sperm-Egg Fusion 11 2     IZUMO2
Oocyte Binding/Fusion Factor1 2 3     Izumo Sperm-Egg Fusion Protein 12
Sperm-Specific Protein Izumo2 3     MGC347995
OBF2 3     

External Ids:    HGNC: 285391   Entrez Gene: 2843592   Ensembl: ENSG000001822647   OMIM: 6092785   UniProtKB: Q8IYV93   

Export aliases for IZUMO1 gene to outside databases

Previous GC identifers: GC19M053939 GC19M045623


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IZUMO1 Gene:
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg
plasma membrane binding and fusion (Inoue et al., 2005 (PubMed 15759005)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IZUMO1 Gene:
IZUMO1 (izumo sperm-egg fusion 1) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot: IZUM1_HUMAN, Q8IYV9
Function: Involved in the fertilization process. May be involved in the fusion of the sperm with the egg




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IZUMO1 gene promoter:
         PPAR-gamma1   p300   MyoD   STAT3   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIZUMO1 promoter sequence
   Search Chromatin IP Primers for IZUMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IZUMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

IZUMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IZUMO1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049244:  view genomic region     (about GC identifiers)

Start:
49,244,109 bp from pter      End:
49,250,166 bp from pter
Size:
6,058 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IZUM1_HUMAN, Q8IYV9 (See protein sequence)
Recommended Name: Izumo sperm-egg fusion protein 1 precursor  
Size: 350 amino acids; 38930 Da
Subunit: Monomer, homodimer and homooligomer (By similarity)
Miscellaneous: Izumo is the name of a Japanese shrine to marriage
Secondary accessions: Q6Q8P6 Q6Q8P7
Alternative splicing: 3 isoforms:  Q8IYV9-1   Q8IYV9-2   Q8IYV9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IZUMO1: NX_Q8IYV9

Explore proteomics data for IZUMO1 at MOPED

Post-translational modifications: 

  • N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm (By
    similarity)1
  • Phosphorylated (By similarity)1
  • Glycosylation2 at Asn204
  • Modification sites at PhosphoSitePlus

  • See IZUMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872381.2  
    ENSEMBL proteins: 
     ENSP00000327786   ENSP00000470144   ENSP00000471815   ENSP00000471134  
    Reactome Protein details: Q8IYV9

    IZUMO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IZUMO1
    OriGene Protein Over-expression Lysate for IZUMO1
    OriGene MassSpec for IZUMO1
    OriGene Custom Protein Services for IZUMO1
    GenScript Custom Purified and Recombinant Proteins Services for IZUMO1
    Novus Biologicals IZUMO1 Lysate
    Sino Biological Recombinant Protein for IZUMO1
    Sino Biological Cell Lysate for IZUMO1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IZUMO1

     
    Search eBioscience for Proteins for IZUMO1 

    IZUMO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IZUMO1
    Novus Biologicals IZUMO1 Antibodies
    Abcam antibodies for IZUMO1
    Cloud-Clone Corp. Antibodies for IZUMO1
    Search ThermoFisher Antibodies for IZUMO1
    LSBio Antibodies in human, mouse, rat for IZUMO1

    IZUMO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IZUMO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IZUMO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IZUMO1
    Cloud-Clone Corp. CLIAs for IZUMO1
    Search eBioscience for ELISAs for IZUMO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8IYV9

    ProtoNet protein and cluster: Q8IYV9

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: IZUM1_HUMAN, Q8IYV9
    Similarity: Belongs to the Izumo family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with IZUMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IZUM1_HUMAN, Q8IYV9
    Function: Involved in the fertilization process. May be involved in the fusion of the sperm with the egg

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS--
         
    Find genes that share ontologies with IZUMO1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Izumo1):
     reproductive system 

    Find genes that share phenotypes with IZUMO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Izumo1tm1Osb for IZUMO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IZUMO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IZUMO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IZUMO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IZUMO1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IZUMO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IZUMO1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IZUMO1
    Predesigned siRNA for gene silencing in human, mouse, rat IZUMO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IZUMO1

    Clone
    Products:
         
    OriGene clones in human, mouse for IZUMO1 (see all 6)
    OriGene ORF clones in mouse, rat for IZUMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IZUMO1 (NM_182575)
    Sino Biological Human cDNA Clone for IZUMO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IZUMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IZUMO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IZUMO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IZUM1_HUMAN, Q8IYV9: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0002080acrosomal membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IDA15759005

    Find genes that share ontologies with IZUMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IZUMO1 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Sperm-Oocyte Membrane Binding0.00
    Fertilization1.00


    Find genes that share SuperPaths with IZUMO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IZUMO1
        Sperm:Oocyte Membrane Binding


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IZUMO1
    Interactions:

        Search GeneGlobe Interaction Network for IZUMO1

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IC15759005
    GO:0007338single fertilization TAS--
    GO:0007342fusion of sperm to egg plasma membrane TAS--
    GO:0032504multicellular organism reproduction TAS--

    Find genes that share ontologies with IZUMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IZUMO1 (IZUM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IZUMO1 gene: 
    NM_182575.2  

    Unigene Cluster for IZUMO1:

    Izumo sperm-egg fusion 1
    Hs.400688  [show with all ESTs]
    Unigene Representative Sequence: AK301750
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599871 ENST00000332955(uc010eme.3 uc010emf.3 uc002pkj.3)
    ENST00000595937 ENST00000595517 ENST00000597553 ENST00000602105
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IZUMO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IZUMO1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IZUMO1
    Predesigned siRNA for gene silencing in human, mouse, rat IZUMO1
    Clone
    Products:
         
    OriGene clones in human, mouse for IZUMO1 (see all 6)
    OriGene ORF clones in mouse, rat for IZUMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IZUMO1 (NM_182575)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IZUMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IZUMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IZUMO1
      QuantiTect SYBR Green Assays in human, mouse, rat IZUMO1
      QuantiFast Probe-based Assays in human, mouse, rat IZUMO1

    Additional mRNA sequence: 

    AB195682.1 AK301750.1 AY552609.1 AY552610.1 BC034769.1 

    5 DOTS entries:

    DT.97790052  DT.102826248  DT.99963967  DT.121466017  DT.95187831 

    Selected AceView cDNA sequences (see all 68):

    AW969501 BC021860 BM906443 BF516076 BF197429 AI241453 AA503542 AI143393 
    CR608210 BE856162 NM_017805 AK123179 BX089325 AK000408 AW772163 BM694838 
    BC028614 AI682390 AI928221 AI808410 AY378097 BQ717077 AI018800 BX389914 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                  -           -                           
    SP2:                    -                             -                                       
    SP3:                                                              -                           


    ECgene alternative splicing isoforms for IZUMO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IZUMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTCCAG
    IZUMO1 Expression
    About this image

    IZUMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IZUMO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.400688

    UniProtKB/Swiss-Prot: IZUM1_HUMAN, Q8IYV9
    Tissue specificity: Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome
    reaction

        Custom PCR Arrays for IZUMO1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IZUMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IZUMO1
    QuantiTect SYBR Green Assays in human, mouse, rat IZUMO1
    QuantiFast Probe-based Assays in human, mouse, rat IZUMO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for IZUMO1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Izumo11 , 5 izumo sperm-egg fusion 11, 5 65.13(n)1
    54.77(a)1
      7 (29.39 cM)5
    734561  NM_001018013.11  NP_001018013.11 
     456218115 


    ENSEMBL Gene Tree for IZUMO1 (if available)
    TreeFam Gene Tree for IZUMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IZUMO1 (see all 159)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348948071,2
    C--49245982(+) CTCTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1907376811,2
    --49246008(+) TAGATG/TAAGTC 1 -- int10--------
    rs8381481,2
    C,F--49246378(-) tggacC/Tcagga 1 -- int16Minor allele frequency- T:0.19WA CSA NA EA 364
    rs1385734751,2
    --49246487(+) GCTATA/GTTGCC 1 -- int10--------
    rs3729516041,2
    C--49246722(+) ACTTTC/G/TGACAA 3 Q P R mis10--------
    rs1416749291,2
    C--49246810(+) TGTATA/TTGCCC 1 -- int10--------
    rs2020853501,2
    --49246826(+) GGGGCA/GTGGCT 1 -- int10--------
    rs8381471,2
    C,F,O,A,H--49246866(-) GATGAC/TCTGGC 1 -- int125Minor allele frequency- T:0.27EA MN NS NA WA CSA 2217
    rs1830260691,2
    C--49246896(+) CAGACA/GAAGGC 1 -- int10--------
    rs124623351,2
    C,F,H--49247024(+) gcgggA/Cggatc 1 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for IZUMO1 (49244109 - 49250166 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IZUMO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3967n71CNV Loss21882294
    dgv3968n71CNV Loss21882294
    nsv912242CNV Loss21882294
    nsv912244CNV Gain21882294
    nsv912238CNV Gain21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IZUMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for IZUMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609278    OMIM disorders: --


    Find genes that share disorders with IZUMO1           About GenesLikeMe

    Genetic Association Database (GAD): IZUMO1
    Human Genome Epidemiology (HuGE) Navigator: IZUMO1 (1 document)

    Export disorders for IZUMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IZUMO1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with IZUMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. (PubMed id 15759005)1, 2, 3, 9 Inoue N.... Okabe M. (Nature 2005)
    2. Preliminary study on the role of the human IZUMO gene in oocyte- spermatozoa fusion failure. (PubMed id 18082733)1, 2, 4 Granados-Gonzalez V.... Levy R. (Fertil. Steril. 2008)
    3. Positive Selection and the Evolution of izumo Genes in Mammals. (PubMed id 22957301)1, 3 Grayson P. and Civetta A. (Int J Evol Biol 2012)
    4. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PubMed id 19658160)1, 3 Ellerman D.A....Primakoff P. (Mol. Reprod. Dev. 2009)
    5. Putative sperm fusion protein IZUMO and the role of N-glycosylation. (PubMed id 18952059)1, 3 Inoue N....Okabe M. (Biochem. Biophys. Res. Commun. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. (PubMed id 23636237)1 Tanaka T....Nettleton J.A. (Am. J. Clin. Nutr. 2013)
    8. Presence and incidence of izumo antibodies in sera of immunoinfertile women and men. (PubMed id 23279005)1 Clark S. and Naz R.K. (Am. J. Reprod. Immunol. 2013)
    9. Novel locus including FGF21 is associated with dietary macronutrient intake. (PubMed id 23372041)1 Chu A.Y....Qi L. (Hum. Mol. Genet. 2013)
    10. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 284359 HGNC: 28539 AceView: RASIP1andMGC34799 Ensembl:ENSG00000182264 euGenes: HUgn284359
    ECgene: IZUMO1 H-InvDB: IZUMO1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IZUMO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IZUMO1 gene:
    Search GeneIP for patents involving IZUMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IZUMO1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IZUMO1  
     OriGene MassSpec something-or-other for IZUMO1   OriGene clones in human, mouse for IZUMO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IZUMO1   OriGene Purified Protein for IZUMO1  
     OriGene ORF clones in mouse, rat for IZUMO1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IZUMO1   OriGene Custom Protein Services for IZUMO1  

     
     
     Block miRNA regulation of human, mouse, rat IZUMO1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IZUMO1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IZUMO1 Predesigned siRNA for gene silencing in human, mouse, rat IZUMO1
     QuantiFast Probe-based Assays in human, mouse, rat IZUMO1 QuantiTect SYBR Green Assays in human, mouse, rat IZUMO1
     Custom PCR Arrays for IZUMO1 Search Chromatin IP Primers for IZUMO1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IZUMO1  Search GeneGlobe Interaction Network for IZUMO1
     Regulatory tfbs in IZUMO1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IZUMO1 GenScript cDNA clones with any tag delivered in your preferred vector for IZUMO1
     GenScript Custom Assay Services for IZUMO1 GenScript Custom overexpressing Cell Line Services for IZUMO1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IZUMO1 (IZUM1)
     Proteins for IZUMO1
     Cell Lysates for IZUMO1
     cDNA Clones for IZUMO1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IZUMO1 antibodies
     IZUMO1 lysates
     Antibodies for IZUMO1
     See all of Abcam's Antibodies, Kits and Proteins for IZUMO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IZUMO1
     Antibodies for IZUMO1
     ELISAs for IZUMO1
     CLIAs for IZUMO1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IZUMO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IZUMO1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IZUMO1
     SwitchGear Promoter luciferase reporter plasmids for IZUMO1
     Search ThermoFisher Antibodies for IZUMO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IZUMO1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IZUMO1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IZUMO1
     LSBio Antibodies in human, mouse, rat for IZUMO1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IZUMO1
      Search eBioscience for proteins for IZUMO1
      Search eBioscience for elisas for IZUMO1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IZUMO1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4