Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IYD Gene

protein-coding   GIFtS: 59
GCID: GC06P150731

Iodotyrosine Deiodinase

(Previous name: chromosome 6 open reading frame 71)
(Previous symbol: C6orf71)
  See IYD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Iodotyrosine Deiodinase1 2     Chromosome 6 Open Reading Frame 711
C6orf711 2 3     dJ422F24.12
DEHAL12 3 5     Iodotyrosine Dehalogenase 12
IYD-12 3     EC 1.22.1.13
TDH42 5     

External Ids:    HGNC: 210711   Entrez Gene: 3894342   Ensembl: ENSG000000097657   OMIM: 6120255   UniProtKB: Q6PHW03   

Export aliases for IYD gene to outside databases

Previous GC identifer: GC06P148255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IYD Gene:
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine,
which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a
membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is
also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis
type 4. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for IYD Gene:
IYD (iodotyrosine deiodinase) is a protein-coding gene. Diseases associated with IYD include croup, and thyroid dyshormonogenesis 4. GO annotations related to this gene include iodide peroxidase activity and oxidoreductase activity.

UniProtKB/Swiss-Prot: IYD1_HUMAN, Q6PHW0
Function: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine
(L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the
hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine

Gene Wiki entry for IYD (Iodotyrosine deiodinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IYD gene promoter:
         COUP-TF1   TBP   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   PPAR-gamma1   COUP-TF   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIYD promoter sequence
   Search Chromatin IP Primers for IYD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IYD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

IYD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IYD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150731:  view genomic region     (about GC identifiers)

Start:
150,690,028 bp from pter      End:
150,727,105 bp from pter
Size:
37,078 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IYD1_HUMAN, Q6PHW0 (See protein sequence)
Recommended Name: Iodotyrosine dehalogenase 1 precursor  
Size: 289 amino acids; 33360 Da
Cofactor: FMN (Probable)
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=AAY41467.1; Type=Erroneous translation; Sequence=BAC85255.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: C9JFW2 Q2VPW0 Q2VPW1 Q5F1L5 Q5F1L6 Q5THM4 Q6ZP69 Q7Z7D7 Q7Z7D8
Alternative splicing: 6 isoforms:  Q6PHW0-1   Q6PHW0-3   Q6PHW0-4   Q6PHW0-5   Q6PHW0-6   Q6PHW0-7   (Ref.1 (AAP22073) sequence is in conflict in position: 265:C->R)

Explore the universe of human proteins at neXtProt for IYD: NX_Q6PHW0

Explore proteomics data for IYD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IYD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158166.1  NP_001158167.1  NP_981932.1  

    ENSEMBL proteins: 
     ENSP00000229447   ENSP00000343763   ENSP00000356304   ENSP00000376085   ENSP00000376084  
     ENSP00000441276   ENSP00000397342   ENSP00000390081  
    Reactome Protein details: Q6PHW0

    IYD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IYD
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IYD
    GenScript Custom Purified and Recombinant Proteins Services for IYD
    Novus Biologicals IYD Protein
    Novus Biologicals IYD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IYD

     
    Search eBioscience for Proteins for IYD 

     
    antibodies-online proteins for IYD (7 products) 

     
    antibodies-online peptides for IYD

    IYD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IYD
    Novus Biologicals IYD Antibodies
    Abcam antibodies for IYD
    Cloud-Clone Corp. Antibodies for IYD
    ThermoFisher Antibodies for IYD
    antibodies-online antibodies for IYD (8 products) 

    IYD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IYD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IYD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IYD
    Cloud-Clone Corp. CLIAs for IYD
    Search eBioscience for ELISAs for IYD 
    antibodies-online kits for IYD (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000415 Nitroreductase-like

    Graphical View of Domain Structure for InterPro Entry Q6PHW0

    ProtoNet protein and cluster: Q6PHW0

    1 Blocks protein domain: IPB000415 Nitroreductase family

    UniProtKB/Swiss-Prot: IYD1_HUMAN, Q6PHW0
    Similarity: Belongs to the nitroreductase family


    Find genes that share domains with IYD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IYD1_HUMAN, Q6PHW0
    Function: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine
    (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the
    hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine
    Catalytic activity: L-tyrosine + 2 NADP(+) + 2 I(-) = 3,5-diiodo-L-tyrosine + 2 NADPH
    Biophysicochemical properties: Kinetic parameters: KM=2.67 uM for L-DIT; KM=1.35 uM for L-MIT;

         Enzyme Number (IUBMB): EC 1.22.1.11

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004447iodide peroxidase activity IEA--
    GO:0016491oxidoreductase activity TAS--
         
    Find genes that share ontologies with IYD           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IYD:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IYD

    miRNA
    Products:
        
    miRTarBase miRNAs that target IYD:
    hsa-mir-335-5p (MIRT017241)

    Block miRNA regulation of human, mouse, rat IYD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IYD (see all 14):
    hsa-miR-130a* hsa-miR-26b* hsa-miR-23c hsa-miR-551b* hsa-miR-606 hsa-miR-1305 hsa-miR-3922-3p hsa-miR-382
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IYD
    Predesigned siRNA for gene silencing in human, mouse, rat IYD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IYD

    Clone
    Products:
         
    OriGene clones in human, mouse for IYD (see all 14)
    OriGene ORF clones in mouse, rat for IYD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IYD (NM_203395)
    Sino Biological Human cDNA Clone for IYD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IYD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IYD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IYD
    Browse ESI BIO Cell Lines and PureStem Progenitors for IYD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IYD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IYD1_HUMAN, Q6PHW0: Cell membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IYD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IYD About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Thyroxine biosynthesis0.00
    Amine-derived hormones0.00
    2Metabolism
    Metabolism0.38
    3Insulin secretion
    Thyroid hormone synthesis0.36


    Find genes that share SuperPaths with IYD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IYD
        Thyroxine biosynthesis


    1 Kegg Pathway  (Kegg details for IYD):
        Thyroid hormone synthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IYD
    Interactions:

        Search GeneGlobe Interaction Network for IYD

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with IYD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IYD (IYD1)

    3 HMDB Compounds for IYD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    IodideIodide (see all 10)20461-54-5--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for IYD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,5-Diiodotyrosine-- 300-39-0target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IYD gene (3 alternative transcripts): 
    NM_001164694.1  NM_001164695.1  NM_203395.2  

    Unigene Cluster for IYD:

    Iodotyrosine deiodinase
    Hs.310225  [show with all ESTs]
    Unigene Representative Sequence: NM_001164694
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229447(uc003qnx.2 uc003qnw.2) ENST00000344419(uc003qnv.2 uc003qnu.2 uc010kik.2)
    ENST00000367335 ENST00000392256 ENST00000392255 ENST00000500320 ENST00000546121
    ENST00000422583 ENST00000425615
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IYD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IYD (see all 14):
    hsa-miR-130a* hsa-miR-26b* hsa-miR-23c hsa-miR-551b* hsa-miR-606 hsa-miR-1305 hsa-miR-3922-3p hsa-miR-382
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IYD
    Predesigned siRNA for gene silencing in human, mouse, rat IYD
    Clone
    Products:
         
    OriGene clones in human, mouse for IYD (see all 14)
    OriGene ORF clones in mouse, rat for IYD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IYD (NM_203395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IYD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IYD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IYD
    OriGene qSTAR qPCR primer pairs in human, mouse for IYD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IYD
      QuantiTect SYBR Green Assays in human, mouse, rat IYD
      QuantiFast Probe-based Assays in human, mouse, rat IYD

    Additional mRNA sequence: 

    AK129950.1 AY259176.1 AY259177.1 AY424901.1 AY424902.2 AY957659.1 AY957660.1 AY957661.1 
    AY957662.1 BC056253.1 

    5 DOTS entries:

    DT.429420  DT.212350  DT.75135587  DT.121334150  DT.100724090 

    Selected AceView cDNA sequences (see all 52):

    BF197599 AY259177 NM_203395 AI627642 AI823392 BE172678 CB163161 AA862523 
    BF431199 AY259176 BQ083170 H59290 BG426800 AW197685 AI248316 BU676096 
    AI767686 AW615276 T95890 AI284243 BC056253 AI985325 BX089449 AI768652 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IYD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGTATTA
    IYD Expression
    About this image


    IYD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Thyroid (Endocrine System)
    IYD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IYD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.310225

    UniProtKB/Swiss-Prot: IYD1_HUMAN, Q6PHW0
    Tissue specificity: Expressed at a high level in thyroid gland and at lower level in kidney and trachea

        Custom PCR Arrays for IYD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IYD
    OriGene qSTAR qPCR primer pairs in human, mouse for IYD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IYD
    QuantiTect SYBR Green Assays in human, mouse, rat IYD
    QuantiFast Probe-based Assays in human, mouse, rat IYD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IYD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IYD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iyd1 , 5 iodotyrosine deiodinase1, 5 84.21(n)1
    85.96(a)1
      10 (2.06 cM)5
    703371  NM_027391.31  NP_081667.11 
     35402405 
    chicken
    (Gallus gallus)
    Aves IYD1 iodotyrosine deiodinase 73.83(n)
    72.89(a)
      421631  XM_419670.3  XP_419670.2 
    lizard
    (Anolis carolinensis)
    Reptilia IYD6
    iodotyrosine deiodinase
    59(a)
    1 ↔ 1
    GL343259.1(555824-567133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia iyd1 iodotyrosine deiodinase 67.25(n)
    71.58(a)
      496718  NM_001011267.1  NP_001011267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003309401 Iodotyrosine dehalogenase 1-like 65.85(n)
    67.72(a)
      100330940  XM_002666422.2  XP_002666468.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62791 CG6279 55.65(n)
    58.05(a)
      39242  NM_001169943.1  NP_001163414.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C02C2.51 C02C2.5 48.09(n)
    43.85(a)
      182108  NM_066311.3  NP_498712.2 


    ENSEMBL Gene Tree for IYD (if available)
    TreeFam Gene Tree for IYD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IYD gene
    1 SIMAP similar gene for IYD using alignment to 5 protein entries:     IYD1_HUMAN (see all proteins):
    DEHAL1

    Find genes that share paralogs with IYD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IYD (see all 1080)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0459654
    Thyroid dyshormonogenesis 4 (TDH4)4--see VAR_0459652 I T mis40--------
    VAR_0459634
    Thyroid dyshormonogenesis 4 (TDH4)4--see VAR_0459632 R W mis40--------
    rs1219181381,2
    Cpathogenic1150709766(+) AGAGAC/TGGTCA 6 R W mis10--------
    rs1219181401,2
    Cpathogenic1150714518(+) CCATCA/GCTTGT 6 T A mis10--------
    rs667881451,2
    C--148256652(+) TGTGT-/TTGT  
            
    GAGAG
    3 -- int12Minor allele frequency- TTGT:0.25NA 4
    rs1999075971,2
    C--148258631(+) TTGTG-/TGGGTCC 3 -- int10--------
    rs2005688711,2
    C--148266775(-) ACAAAA/GGTTGA 3 -- int10--------
    rs2010239321,2
    C--148268615(-) CCATTA/TAATTG 3 -- int10--------
    rs674283531,2
    C--148271518(+) GTGAT-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs350697861,2
    C--148271527(+) AAAAA-/A/AA  
            
    GATTG
    3 -- int11NA 2

    HapMap Linkage Disequilibrium report for IYD (150690028 - 150727105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IYD (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732880CNV Deletion23290073
    esv1594235CNV Deletion17803354
    esv2732883CNV Deletion23290073
    esv2732881CNV Deletion23290073
    esv2732886CNV Deletion23290073
    esv2732882CNV Deletion23290073
    esv1485241CNV Deletion17803354
    esv2732885CNV Deletion23290073
    esv2625832CNV Insertion19546169
    nsv464078CNV Loss19166990

    Human Gene Mutation Database (HGMD): IYD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IYD
    DNA2.0 Custom Variant and Variant Library Synthesis for IYD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612025   
    OMIM disorders: 274800  
    UniProtKB/Swiss-Prot: IYD1_HUMAN, Q6PHW0
  • Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing
    severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits
    derived from unrecognized and untreated hypothyroidism. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 6 diseases for IYD:    
    About MalaCards
    croup    thyroid dyshormonogenesis 4    congenital hypothyroidism, iyd-related    rapsn-related congenital myasthenic syndrome
    congenital hypothyroidism    hypothyroidism

    2 diseases from the University of Copenhagen DISEASES database for IYD:
    Hypothyroidism     Croup

    Find genes that share disorders with IYD           About GenesLikeMe

    Genetic Association Database (GAD): IYD
    Human Genome Epidemiology (HuGE) Navigator: IYD (1 document)

    Export disorders for IYD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IYD gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with IYD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. (PubMed id 15289438)1, 2, 3, 9 Gnidehou S.... Dupuy C. (FASEB J. 2004)
    2. Mutations in the iodotyrosine deiodinase gene and hypothyroidism. (PubMed id 18434651)1, 2 Moreno J.C.... Visser T.J. (N. Engl. J. Med. 2008)
    3. Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. (PubMed id 16316988)1, 3 Friedman J.E....Rokita S.E. (J. Biol. Chem. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Characterisation of DEHAL1 expression in thyroid pathologies. (PubMed id 17322488)1, 9 Krause K....Fuhrer D. (Eur. J. Endocrinol. 2007)
    8. Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B. (PubMed id 16910871)1, 9 Gnidehou S....Dupuy C. (Thyroid 2006)
    9. Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. (PubMed id 19436071)1, 9 Thomas S.R....Rokita S.E. (J. Biol. Chem. 2009)
    10. Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations. (PubMed id 20298747)1, 9 Moreno J.C. and Visser T.J. (Mol. Cell. Endocrinol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 389434 HGNC: 21071 AceView: DEHAL1 Ensembl:ENSG00000009765 euGenes: HUgn389434
    ECgene: IYD Kegg: 389434 H-InvDB: IYD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IYD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IYD gene:
    Search GeneIP for patents involving IYD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IYD  
     OriGene qPCR primer pairs and template standards for IYD   OriGene Protein Over-expression Lysate for IYD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IYD  
     OriGene qSTAR qPCR primer pairs in human, mouse for IYD   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IYD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IYD   OriGene Custom Protein Services for IYD  

     
     
     Block miRNA regulation of human, mouse, rat IYD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IYD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IYD Predesigned siRNA for gene silencing in human, mouse, rat IYD
     QuantiFast Probe-based Assays in human, mouse, rat IYD QuantiTect SYBR Green Assays in human, mouse, rat IYD
     Custom PCR Arrays for IYD Search Chromatin IP Primers for IYD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IYD  Search GeneGlobe Interaction Network for IYD
     Regulatory tfbs in IYD promoter
     GenScript Custom Purified and Recombinant Proteins Services for IYD GenScript cDNA clones with any tag delivered in your preferred vector for IYD
     GenScript Custom Assay Services for IYD GenScript Custom overexpressing Cell Line Services for IYD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IYD (IYD1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IYD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IYD antibodies
     IYD proteins
     IYD lysates
     Antibodies for IYD
     See all of Abcam's Antibodies, Kits and Proteins for IYD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IYD
     Antibodies for IYD
     ELISAs for IYD
     CLIAs for IYD



     Browse ESI BIO Cell Lines and PureStem Progenitors for IYD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IYD
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IYD
     SwitchGear Promoter luciferase reporter plasmids for IYD
     ThermoFisher Antibodies for IYD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IYD
     Browse compounds at ApexBio
     Search Addgene for plasmids for IYD
      Search eBioscience for proteins for IYD
      Search eBioscience for elisas for IYD
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IYD
     antibodies-online antibodies for IYD (8 products)
     antibodies-online kits for IYD (8 products)
     antibodies-online peptides for IYD
     antibodies-online proteins for IYD (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IYD gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4