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Aliases for IWS1 Gene

Aliases for IWS1 Gene

  • IWS1, SUPT6H Interacting Protein 2 3
  • IWS1 Homolog (S. Cerevisiae) 2 5
  • IWS1-Like Protein 4
  • IWS1L 4

External Ids for IWS1 Gene

Previous GeneCards Identifiers for IWS1 Gene

  • GC02M127955
  • GC02M128193
  • GC02M120545

Summaries for IWS1 Gene

GeneCards Summary for IWS1 Gene

IWS1 (IWS1, SUPT6H Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IWS1 Gene

  • Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Gene Wiki entry for IWS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IWS1 Gene

Genomics for IWS1 Gene

Regulatory Elements for IWS1 Gene

Promoters for IWS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IWS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IWS1 Gene

Chromosome:
2
Start:
127,436,207 bp from pter
End:
127,526,886 bp from pter
Size:
90,680 bases
Orientation:
Minus strand

Genomic View for IWS1 Gene

Genes around IWS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IWS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IWS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IWS1 Gene

Proteins for IWS1 Gene

  • Protein details for IWS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST2-IWS1_HUMAN
    Recommended name:
    Protein IWS1 homolog
    Protein Accession:
    Q96ST2
    Secondary Accessions:
    • Q2TB65
    • Q6P157
    • Q8N3E8
    • Q96MI7
    • Q9NV97
    • Q9NWH8

    Protein attributes for IWS1 Gene

    Size:
    819 amino acids
    Molecular mass:
    91955 Da
    Quaternary structure:
    • Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5. Interacts with HDGFRP2.
    SequenceCaution:
    • Sequence=AAH65279.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IWS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IWS1 Gene

Proteomics data for IWS1 Gene at MOPED

Post-translational modifications for IWS1 Gene

  • Ubiquitination at Lys 767
  • Modification sites at PhosphoSitePlus

Other Protein References for IWS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IWS1 Gene

Domains & Families for IWS1 Gene

Protein Domains for IWS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IWS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96ST2

UniProtKB/Swiss-Prot:

IWS1_HUMAN :
  • Contains 1 TFIIS N-terminal domain.
  • Belongs to the IWS1 family.
Domain:
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the IWS1 family.
genes like me logo Genes that share domains with IWS1: view

No data available for Gene Families for IWS1 Gene

Function for IWS1 Gene

Molecular function for IWS1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Phenotypes for IWS1 Gene

GenomeRNAi human phenotypes for IWS1:
genes like me logo Genes that share phenotypes with IWS1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IWS1 Gene

Localization for IWS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IWS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IWS1 Gene COMPARTMENTS Subcellular localization image for IWS1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for IWS1 Gene

Pathways & Interactions for IWS1 Gene

SuperPathways for IWS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010793 regulation of mRNA export from nucleus IMP 17234882
GO:0050684 regulation of mRNA processing IMP 17234882
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with IWS1: view

No data available for Pathways by source and SIGNOR curated interactions for IWS1 Gene

Drugs & Compounds for IWS1 Gene

No Compound Related Data Available

Transcripts for IWS1 Gene

Unigene Clusters for IWS1 Gene

IWS1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IWS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b ^ 9 ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IWS1 Gene

GeneLoc Exon Structure for
IWS1
ECgene alternative splicing isoforms for
IWS1

Expression for IWS1 Gene

mRNA expression in normal human tissues for IWS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IWS1 Gene

This gene is overexpressed in Adrenal (32.4), Peripheral blood mononuclear cells (8.3), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IWS1 Gene



SOURCE GeneReport for Unigene cluster for IWS1 Gene Hs.469879

genes like me logo Genes that share expression patterns with IWS1: view

Protein tissue co-expression partners for IWS1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IWS1 Gene

Orthologs for IWS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IWS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IWS1 35
  • 99.59 (n)
  • 99.51 (a)
IWS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IWS1 36
  • 93 (a)
OneToOne
IWS1 35
  • 89.61 (n)
  • 90.83 (a)
dog
(Canis familiaris)
Mammalia IWS1 35
  • 89.82 (n)
  • 91.78 (a)
IWS1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iws1 16
Iws1 36
  • 90 (a)
OneToOne
Iws1 35
  • 88.2 (n)
  • 90.43 (a)
oppossum
(Monodelphis domestica)
Mammalia IWS1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Iws1 35
  • 86.35 (n)
  • 87.93 (a)
chicken
(Gallus gallus)
Aves IWS1 36
  • 79 (a)
OneToOne
IWS1 35
  • 74.52 (n)
  • 74.96 (a)
lizard
(Anolis carolinensis)
Reptilia IWS1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12317 35
tropical clawed frog
(Silurana tropicalis)
Amphibia iws1 35
  • 66 (n)
  • 67.54 (a)
Str.2923 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6347 35
zebrafish
(Danio rerio)
Actinopterygii IWS1 36
  • 57 (a)
OneToOne
Dr.690 35
LOC100329390 35
  • 60.97 (n)
  • 61.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9915 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13B12.1 35
  • 49.1 (n)
  • 43.24 (a)
F13B12.1 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPN1 36
  • 26 (a)
OneToOne
SPN1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for IWS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IWS1 Gene

ENSEMBL:
Gene Tree for IWS1 (if available)
TreeFam:
Gene Tree for IWS1 (if available)

Paralogs for IWS1 Gene

No data available for Paralogs for IWS1 Gene

Variants for IWS1 Gene

Sequence variations from dbSNP and Humsavar for IWS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34377117 - 127,504,734(+) TCTTC(A/G)CTACT nc-transcript-variant, reference, missense
rs34785867 - 127,503,523(+) TGATA(C/T)AGCAT nc-transcript-variant, reference, missense
rs191379 -- 127,514,358(+) ggggt(A/G)tctaa intron-variant
rs334137 -- 127,515,098(+) TAATC(A/G)CTCAT intron-variant
rs334138 -- 127,514,892(+) caggc(A/G)aatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IWS1 Gene

Variant ID Type Subtype PubMed ID
nsv875014 CNV Loss 21882294
nsv2912 CNV Loss 18451855

Variation tolerance for IWS1 Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IWS1 Gene

HapMap Linkage Disequilibrium report
IWS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IWS1 Gene

Disorders for IWS1 Gene

Relevant External Links for IWS1

Genetic Association Database (GAD)
IWS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IWS1

No disorders were found for IWS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IWS1 Gene

Publications for IWS1 Gene

  1. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (PMID: 17234882) Yoh S.M. … Jones K.A. (Genes Dev. 2007) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3
  4. The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells. (PMID: 25590759) GAcrard A. … Emiliani S. (Cell Host Microbe 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for IWS1 Gene

Sources for IWS1 Gene

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