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Aliases for IWS1 Gene

Aliases for IWS1 Gene

  • IWS1, SUPT6H Interacting Protein 2 3 5
  • IWS1 Homolog (S. Cerevisiae) 2
  • IWS1-Like Protein 4
  • IWS1L 4

External Ids for IWS1 Gene

Previous GeneCards Identifiers for IWS1 Gene

  • GC02M127955
  • GC02M128193
  • GC02M120545

Summaries for IWS1 Gene

GeneCards Summary for IWS1 Gene

IWS1 (IWS1, SUPT6H Interacting Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat.

UniProtKB/Swiss-Prot for IWS1 Gene

  • Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Gene Wiki entry for IWS1 Gene

Additional gene information for IWS1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IWS1 Gene

Genomics for IWS1 Gene

GeneHancer (GH) Regulatory Elements for IWS1 Gene

Promoters and enhancers for IWS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I127525 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.9 -0.2 -244 4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IWS1 MAP3K2 AMMECR1L WDR33 ENSG00000236682 UGGT1 ENSG00000272789 ENSG00000231731 SFT2D3 GC02P127529
GH02I127507 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +17.2 17178 4.9 PKNOX1 SIN3A FEZF1 ZNF2 ATF7 FOS REST TSHZ1 MAFF SMARCA4 SFT2D3 ENSG00000236682 MYO7B RNU4-48P LIMS2 ERCC3 IWS1 ENSG00000231731 AMMECR1L MAP3K2
GH02I127534 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 4.5 -9.2 -9154 3.6 NFIA NR4A1 ZNF48 MEF2D NFIC ZFHX2 NR2C1 ZNF24 HNF4A EGR2 MYO7B GPR17 ENSG00000236682 MAP3K2 ERCC3 IWS1 LOC105373609
GH02I127540 Enhancer 1 ENCODE dbSUPER 5.3 -15.2 -15243 3.2 HDAC1 FOXA2 ARNT ZSCAN4 ARID4B CHAMP1 TCF12 ATF7 CAVIN1 ZBTB2 ENSG00000236682 MYO7B GPR17 ERCC3 IWS1 LOC105373609
GH02I127523 Enhancer 0.6 dbSUPER 8.5 +3.1 3086 1.4 SCRT1 FOXA2 RXRA TAF1 REST GABPA YY1 ZNF121 JUND ATF3 IWS1 GC02M127501
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IWS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IWS1 gene promoter:

Genomic Locations for IWS1 Gene

Genomic Locations for IWS1 Gene
chr2:127,436,207-127,526,886
(GRCh38/hg38)
Size:
90,680 bases
Orientation:
Minus strand
chr2:128,193,783-128,284,462
(GRCh37/hg19)

Genomic View for IWS1 Gene

Genes around IWS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IWS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IWS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IWS1 Gene

Proteins for IWS1 Gene

  • Protein details for IWS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST2-IWS1_HUMAN
    Recommended name:
    Protein IWS1 homolog
    Protein Accession:
    Q96ST2
    Secondary Accessions:
    • Q2TB65
    • Q6P157
    • Q8N3E8
    • Q96MI7
    • Q9NV97
    • Q9NWH8

    Protein attributes for IWS1 Gene

    Size:
    819 amino acids
    Molecular mass:
    91955 Da
    Quaternary structure:
    • Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5. Interacts with HDGFRP2.
    SequenceCaution:
    • Sequence=AAH65279.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IWS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IWS1 Gene

Post-translational modifications for IWS1 Gene

  • Ubiquitination at isoforms=2, 3767

No data available for DME Specific Peptides for IWS1 Gene

Domains & Families for IWS1 Gene

Gene Families for IWS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IWS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IWS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96ST2

UniProtKB/Swiss-Prot:

IWS1_HUMAN :
  • Belongs to the IWS1 family.
Family:
  • Belongs to the IWS1 family.
genes like me logo Genes that share domains with IWS1: view

Function for IWS1 Gene

Molecular function for IWS1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Phenotypes From GWAS Catalog for IWS1 Gene

Gene Ontology (GO) - Molecular Function for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17234882
genes like me logo Genes that share ontologies with IWS1: view

Phenotypes for IWS1 Gene

GenomeRNAi human phenotypes for IWS1:
genes like me logo Genes that share phenotypes with IWS1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IWS1 Gene

Localization for IWS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IWS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IWS1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17234882
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with IWS1: view

Pathways & Interactions for IWS1 Gene

genes like me logo Genes that share pathways with IWS1: view

Gene Ontology (GO) - Biological Process for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with IWS1: view

No data available for SIGNOR curated interactions for IWS1 Gene

Drugs & Compounds for IWS1 Gene

No Compound Related Data Available

Transcripts for IWS1 Gene

Unigene Clusters for IWS1 Gene

IWS1 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IWS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b ^ 9 ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IWS1 Gene

GeneLoc Exon Structure for
IWS1
ECgene alternative splicing isoforms for
IWS1

Expression for IWS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IWS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IWS1 Gene

This gene is overexpressed in Adrenal (32.4), Peripheral blood mononuclear cells (8.3), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IWS1 Gene



Protein tissue co-expression partners for IWS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IWS1 Gene:

IWS1

SOURCE GeneReport for Unigene cluster for IWS1 Gene:

Hs.469879

Evidence on tissue expression from TISSUES for IWS1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Blood(4.2)
  • Eye(4.1)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with IWS1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IWS1 Gene

Orthologs for IWS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IWS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IWS1 33 34
  • 99.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IWS1 33 34
  • 89.82 (n)
cow
(Bos Taurus)
Mammalia IWS1 33 34
  • 89.61 (n)
mouse
(Mus musculus)
Mammalia Iws1 33 16 34
  • 88.2 (n)
rat
(Rattus norvegicus)
Mammalia Iws1 33
  • 86.35 (n)
oppossum
(Monodelphis domestica)
Mammalia IWS1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IWS1 33 34
  • 74.52 (n)
lizard
(Anolis carolinensis)
Reptilia IWS1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iws1 33
  • 66 (n)
Str.2923 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12317 33
zebrafish
(Danio rerio)
Actinopterygii LOC100329390 33
  • 60.97 (n)
IWS1 34
  • 57 (a)
OneToOne
Dr.690 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6347 33
fruit fly
(Drosophila melanogaster)
Insecta CG9915 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13B12.1 33 34
  • 49.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPN1 34 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToOne
Species where no ortholog for IWS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IWS1 Gene

ENSEMBL:
Gene Tree for IWS1 (if available)
TreeFam:
Gene Tree for IWS1 (if available)

Paralogs for IWS1 Gene

No data available for Paralogs for IWS1 Gene

Variants for IWS1 Gene

Sequence variations from dbSNP and Humsavar for IWS1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000044134 -- 127,494,573(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000071030 -- 127,508,945(-) T/C intron_variant
rs1000150372 -- 127,526,980(-) A/T upstream_transcript_variant
rs1000275938 -- 127,502,389(-) T/C intron_variant
rs1000318920 -- 127,515,429(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IWS1 Gene

Variant ID Type Subtype PubMed ID
nsv2912 CNV deletion 18451855

Variation tolerance for IWS1 Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IWS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IWS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IWS1 Gene

Disorders for IWS1 Gene

Additional Disease Information for IWS1

No disorders were found for IWS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IWS1 Gene

Publications for IWS1 Gene

  1. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (PMID: 17234882) Yoh SM … Jones KA (Genes & development 2007) 2 3 4 58
  2. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K … Zhang P (Biochemical and biophysical research communications 2015) 3 4 58
  3. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (PMID: 19141475) Yoh SM … Jones KA (Genes & development 2008) 3 4 58
  4. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. (PMID: 17184735) Liu Z … Bao S (Biochemical and biophysical research communications 2007) 3 4 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for IWS1 Gene

Sources for IWS1 Gene

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