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Aliases for IWS1 Gene

Aliases for IWS1 Gene

  • IWS1, SUPT6H Interacting Protein 2 3 5
  • IWS1 Homolog (S. Cerevisiae) 2
  • IWS1-Like Protein 4
  • IWS1L 4

External Ids for IWS1 Gene

Previous GeneCards Identifiers for IWS1 Gene

  • GC02M127955
  • GC02M128193
  • GC02M120545

Summaries for IWS1 Gene

GeneCards Summary for IWS1 Gene

IWS1 (IWS1, SUPT6H Interacting Protein) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Translational Control.

UniProtKB/Swiss-Prot for IWS1 Gene

  • Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Gene Wiki entry for IWS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IWS1 Gene

Genomics for IWS1 Gene

Regulatory Elements for IWS1 Gene

Enhancers for IWS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F127525 1.7 FANTOM5 Ensembl ENCODE 9.9 -0.2 -244 4.0 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 AMMECR1L ENSG00000236682 IWS1 WDR33 ENSG00000272789 LOC105373607 MAP3K2 SFT2D3 GC02P127529
GH02F127507 1.6 FANTOM5 Ensembl ENCODE 8.3 +17.2 17179 4.9 PKNOX1 SIN3A FEZF1 ZNF2 FOS ZNF263 TSHZ1 ZNF264 MAFF PBX2 AMMECR1L SFT2D3 ENSG00000236682 WDR33 UGGT1 MYO7B RNU4-48P LIMS2 ERCC3 IWS1
GH02F127404 1.4 Ensembl ENCODE 5.3 +118.4 118414 8.5 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 MAP3K2 ERCC3 ENSG00000236682 IWS1 PROC GC02P127390
GH02F127540 0.9 ENCODE 5.2 -15.2 -15243 3.2 HDAC1 ARID4B CHAMP1 GATA2 ZBTB2 NCOA1 ZEB2 SMARCA4 PBX2 IKZF1 ENSG00000236682 MYO7B GPR17 ERCC3 IWS1 LOC105373609
GH02F127480 0.5 ENCODE 8.1 +46.3 46272 1.0 CBX3 POLR2A TEAD4 ENSG00000236682 IWS1 LOC105373607 RNU4-48P GC02M127501
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IWS1 on UCSC Golden Path with GeneCards custom track

Promoters for IWS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303904 686 2801 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for IWS1 Gene

Chromosome:
2
Start:
127,436,207 bp from pter
End:
127,526,886 bp from pter
Size:
90,680 bases
Orientation:
Minus strand

Genomic View for IWS1 Gene

Genes around IWS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IWS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IWS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IWS1 Gene

Proteins for IWS1 Gene

  • Protein details for IWS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST2-IWS1_HUMAN
    Recommended name:
    Protein IWS1 homolog
    Protein Accession:
    Q96ST2
    Secondary Accessions:
    • Q2TB65
    • Q6P157
    • Q8N3E8
    • Q96MI7
    • Q9NV97
    • Q9NWH8

    Protein attributes for IWS1 Gene

    Size:
    819 amino acids
    Molecular mass:
    91955 Da
    Quaternary structure:
    • Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5. Interacts with HDGFRP2.
    SequenceCaution:
    • Sequence=AAH65279.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IWS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IWS1 Gene

Post-translational modifications for IWS1 Gene

  • Ubiquitination at Lys 767
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IWS1 Gene

Domains & Families for IWS1 Gene

Protein Domains for IWS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IWS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96ST2

UniProtKB/Swiss-Prot:

IWS1_HUMAN :
  • Contains 1 TFIIS N-terminal domain.
  • Belongs to the IWS1 family.
Domain:
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the IWS1 family.
genes like me logo Genes that share domains with IWS1: view

No data available for Gene Families for IWS1 Gene

Function for IWS1 Gene

Molecular function for IWS1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Gene Ontology (GO) - Molecular Function for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17234882
genes like me logo Genes that share ontologies with IWS1: view

Phenotypes for IWS1 Gene

GenomeRNAi human phenotypes for IWS1:
genes like me logo Genes that share phenotypes with IWS1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IWS1 Gene

Localization for IWS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IWS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IWS1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17234882
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with IWS1: view

Pathways & Interactions for IWS1 Gene

genes like me logo Genes that share pathways with IWS1: view

Gene Ontology (GO) - Biological Process for IWS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with IWS1: view

No data available for SIGNOR curated interactions for IWS1 Gene

Transcripts for IWS1 Gene

Unigene Clusters for IWS1 Gene

IWS1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IWS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b ^ 9 ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IWS1 Gene

GeneLoc Exon Structure for
IWS1
ECgene alternative splicing isoforms for
IWS1

Expression for IWS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IWS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IWS1 Gene

This gene is overexpressed in Adrenal (32.4), Peripheral blood mononuclear cells (8.3), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IWS1 Gene



Protein tissue co-expression partners for IWS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IWS1 Gene:

IWS1

SOURCE GeneReport for Unigene cluster for IWS1 Gene:

Hs.469879
genes like me logo Genes that share expression patterns with IWS1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IWS1 Gene

Orthologs for IWS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IWS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IWS1 34 35
  • 99.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IWS1 34 35
  • 89.82 (n)
cow
(Bos Taurus)
Mammalia IWS1 34 35
  • 89.61 (n)
mouse
(Mus musculus)
Mammalia Iws1 34 16 35
  • 88.2 (n)
rat
(Rattus norvegicus)
Mammalia Iws1 34
  • 86.35 (n)
oppossum
(Monodelphis domestica)
Mammalia IWS1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IWS1 34 35
  • 74.52 (n)
lizard
(Anolis carolinensis)
Reptilia IWS1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iws1 34
  • 66 (n)
Str.2923 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12317 34
zebrafish
(Danio rerio)
Actinopterygii LOC100329390 34
  • 60.97 (n)
IWS1 35
  • 57 (a)
OneToOne
Dr.690 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6347 34
fruit fly
(Drosophila melanogaster)
Insecta CG9915 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13B12.1 34 35
  • 49.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPN1 35 37
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToOne
Species where no ortholog for IWS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IWS1 Gene

ENSEMBL:
Gene Tree for IWS1 (if available)
TreeFam:
Gene Tree for IWS1 (if available)

Paralogs for IWS1 Gene

No data available for Paralogs for IWS1 Gene

Variants for IWS1 Gene

Sequence variations from dbSNP and Humsavar for IWS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10172132 -- 127,492,316(+) gaggc(A/G)ggtgg intron-variant
rs10172273 -- 127,492,456(+) cagga(G/T)aatcg intron-variant
rs10175642 -- 127,523,553(+) CTTAT(A/G)CTCCT intron-variant
rs10187760 -- 127,514,704(+) gccag(A/C)gcctg intron-variant
rs10190409 -- 127,515,064(+) CATTG(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IWS1 Gene

Variant ID Type Subtype PubMed ID
nsv2912 CNV deletion 18451855

Variation tolerance for IWS1 Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IWS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IWS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IWS1 Gene

Disorders for IWS1 Gene

Relevant External Links for IWS1

Genetic Association Database (GAD)
IWS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IWS1

No disorders were found for IWS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IWS1 Gene

Publications for IWS1 Gene

  1. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (PMID: 17234882) Yoh S.M. … Jones K.A. (Genes Dev. 2007) 2 3 4 64
  2. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. (PMID: 25689719) Gao K. … Zhang P. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
  3. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (PMID: 19141475) Yoh S.M. … Jones K.A. (Genes Dev. 2008) 3 4 64
  4. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. (PMID: 17184735) Liu Z. … Bao S. (Biochem. Biophys. Res. Commun. 2007) 3 4 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for IWS1 Gene

Sources for IWS1 Gene

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