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IWS1 Gene

protein-coding   GIFtS: 50
GCID: GC02M128193

IWS1 Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IWS1 Homolog (S. Cerevisiae)1 2
IWS1-Like Protein2 3
Interacts With Spt62
Protein IWS1 Homolog2
IWS1L3

External Ids:    HGNC: 254671   Entrez Gene: 556772   Ensembl: ENSG000001631667   UniProtKB: Q96ST23   

Export aliases for IWS1 gene to outside databases

Previous GC identifers: GC02M127955 GC02M120545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IWS1 Gene:
IWS1 (IWS1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with IWS1 include dentinogenesis imperfecta 1, and dentinogenesis imperfecta.

UniProtKB/Swiss-Prot: IWS1_HUMAN, Q96ST2
Function: Transcription factor which plays a key role in defining the composition of the RNA polymerase II
(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly
factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to
the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1
(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone
modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled
H3K36 methylation, a signature chromatin mark of active transcription

Gene Wiki entry for IWS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IWS1 gene promoter:
         E2F-4   E2F-3a   ER-alpha   E2F-5   p53   ATF-2   IRF-1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIWS1 promoter sequence
   Search Chromatin IP Primers for IWS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IWS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q14.3

IWS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IWS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128193:  view genomic region     (about GC identifiers)

Start:
128,193,783 bp from pter      End:
128,284,462 bp from pter
Size:
90,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IWS1_HUMAN, Q96ST2 (See protein sequence)
Recommended Name: Protein IWS1 homolog  
Size: 819 amino acids; 91955 Da
Subunit: Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4,
SETD2 and PRMT5
Sequence caution: Sequence=AAH65279.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91858.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q2TB65 Q6P157 Q8N3E8 Q96MI7 Q9NV97 Q9NWH8
Alternative splicing: 3 isoforms:  Q96ST2-1   Q96ST2-2   Q96ST2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IWS1: NX_Q96ST2

Explore proteomics data for IWS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys767
  • Modification sites at PhosphoSitePlus

  • See IWS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060439.2  
    ENSEMBL proteins: 
     ENSP00000396710   ENSP00000295321   ENSP00000387206   ENSP00000399245  

    IWS1 Human Recombinant Protein Products:

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    IWS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for IWS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q96ST2

    ProtoNet protein and cluster: Q96ST2

    UniProtKB/Swiss-Prot: IWS1_HUMAN, Q96ST2
    Similarity: Belongs to the IWS1 family
    Similarity: Contains 1 TFIIS N-terminal domain


    IWS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IWS1_HUMAN, Q96ST2
    Function: Transcription factor which plays a key role in defining the composition of the RNA polymerase II
    (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly
    factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to
    the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1
    (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone
    modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled
    H3K36 methylation, a signature chromatin mark of active transcription

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17234882
         
    IWS1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IWS1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IWS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IWS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IWS1:
    hsa-mir-16-5p (MIRT031971), hsa-mir-193b-3p (MIRT041528)

    Block miRNA regulation of human, mouse, rat IWS1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IWS1:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidIWS1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IWS1
    Predesigned siRNA for gene silencing in human, mouse, rat IWS1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IWS1 (NM_017969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IWS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IWS1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IWS1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IWS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IWS1_HUMAN, Q96ST2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    IWS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IWS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IWS1
        Translational Control



    IWS1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IWS1
    Interactions:

        Search GeneGlobe Interaction Network for IWS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IWS1 (Q96ST23 ENSP000002953214) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETD2Q9BYW23, ENSP000003867594I2D: score=1 STRING: ENSP00000386759
    SUPT6HQ7KZ853, ENSP000003191044I2D: score=1 STRING: ENSP00000319104
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    KBTBD7Q8WVZ93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0010793regulation of mRNA export from nucleus IMP17234882

    IWS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IWS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IWS1 gene: 
    NM_017969.2  

    Unigene Cluster for IWS1:

    IWS1 homolog (S. cerevisiae)
    Hs.469879  [show with all ESTs]
    Unigene Representative Sequence: NM_017969
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412979 ENST00000295321(uc010yzl.1 uc002ton.2 uc010fma.2)
    ENST00000497888 ENST00000495369 ENST00000409725 ENST00000486662 ENST00000479083
    ENST00000478949 ENST00000460511 ENST00000483889 ENST00000436740 ENST00000455721

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IWS1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IWS1:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidIWS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IWS1
    Predesigned siRNA for gene silencing in human, mouse, rat IWS1
    Clone
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    OriGene clones in human, mouse for IWS1 (see all 6)
    OriGene ORF clones in mouse, rat for IWS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IWS1 (NM_017969)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IWS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IWS1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IWS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IWS1
      QuantiTect SYBR Green Assays in human, mouse, rat IWS1
      QuantiFast Probe-based Assays in human, mouse, rat IWS1

    Additional mRNA sequence: 

    AK000868.1 AK001717.1 AK027561.1 AK056881.1 AK294669.1 AK296848.1 AK309006.1 AL834178.1 
    BC017012.2 BC065279.1 BC110536.1 BC110537.1 

    18 DOTS entries:

    DT.445889  DT.100786048  DT.100786061  DT.120969741  DT.40113269  DT.91762095  DT.100786046  DT.120969723 
    DT.95108071  DT.100664924  DT.120969746  DT.40128203  DT.100786042  DT.120969720  DT.99991478  DT.86846841 
    DT.95108036  DT.120969751 

    Selected AceView cDNA sequences (see all 263):

    BC017012 AA857819 BP353876 AI632208 BM667591 CF890880 CA444423 CB321934 
    AA936517 AA598439 BE464162 BQ231489 AK000868 AA704787 AI806056 BM828974 
    BQ900745 BP358935 AA057868 AI215901 BC065279 BF063222 BM467362 BM712471 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IWS1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b ^ 9 ^
    SP1:                                                                                                                                                            
    SP2:              -     -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP3:              -     -     -     -     -     -                       -     -     -                                                                           
    SP4:                                                                    -     -     -                                                                           
    SP5:                                      -     -                       -     -     -                                                                           

    ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for IWS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IWS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IWS1 Expression
    About this image


    IWS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IWS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IWS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469879
        Custom PCR Arrays for IWS1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IWS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IWS1
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    QuantiFast Probe-based Assays in human, mouse, rat IWS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IWS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IWS1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iws11 , 5 IWS1 homolog (S. cerevisiae)1, 5 88.2(n)1
    90.43(a)1
      18 (17.92 cM)5
    734731  NM_173441.31  NP_775617.11 
     320677345 
    chicken
    (Gallus gallus)
    Aves IWS11 IWS1 homolog (S. cerevisiae) 74.52(n)
    74.96(a)
      424750  XM_004936950.1  XP_004937007.1 
    lizard
    (Anolis carolinensis)
    Reptilia IWS16
    IWS1 homolog (S. cerevisiae)
    71(a)
    1 ↔ 1
    3(36101806-36121039)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123172 Xenopus laevis transcribed sequence with weak similarity more 73.71(n)    48016747 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.6902 Transcribed sequence with weak similarity to protein more 75.84(n)    57052041 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99156
    --
    28(a)
    1 ↔ 1
    X(16204131-16207171)
    worm
    (Caenorhabditis elegans)
    Secernentea F13B12.11 F13B12.1 49.1(n)
    43.24(a)
      177934  NM_069523.4  NP_501924.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPN1(YPR133C)4 Protein involved in RNA polymerase II transcription; more   --   16(797210-795978) 856251  NP_015458.1 


    ENSEMBL Gene Tree for IWS1 (if available)
    TreeFam Gene Tree for IWS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IWS1 (see all 1097)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441394551,2
    C--128237897(+) GCAGAA/GCTTCT 1 -- ds50010--------
    rs116828641,2
    C,F,H--128237987(+) tgtggG/Agtcca 1 -- ds50015Minor allele frequency- A:0.21NA WA EA 246
    rs1473251571,2
    C--128238069(+) CTCCCA/GGGTCC 1 -- ds50010--------
    rs758733471,2
    C--128238084(+) GGCCCA/TACCCT 1 -- ds50010--------
    rs775711001,2
    C--128238085(+) GCCCAA/CCCCTC 1 -- ds50010--------
    rs562171221,2
    C,F--128238154(+) GTTAGC/TATAAC 1 -- ds50016Minor allele frequency- T:0.20WA CSA NA EA 363
    rs116945811,2
    C,F,A,H--128238166(+) AGAGAC/TGCTCT 1 -- ds500118Minor allele frequency- T:0.46NS EA NA WA 2342
    rs1390696441,2
    --128238209(+) TCCTTA/GTCAGC 1 -- ds50010--------
    rs756351051,2
    --128238212(+) TTGTCA/CGCAAC 1 -- ds50010--------
    rs1508558811,2
    --128238267(+) GAGGAC/TTGAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IWS1 (128193783 - 128284462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IWS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875014CNV Loss21882294
    nsv2912CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for IWS1:    
    About MalaCards
    dentinogenesis imperfecta 1    dentinogenesis imperfecta    tonsillitis    thyroiditis
    cerebritis    malaria    endotheliitis


    IWS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IWS1

    Export disorders for IWS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IWS1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with IWS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (PubMed id 19141475)1, 2 Yoh S.M....Jones K.A. (amp 2008)
    2. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. (PubMed id 17184735)1, 2 Liu Z....Bao S. (Biochem. Biophys. Res. Commun. 2007)
    3. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (PubMed id 17234882)1, 2 Yoh S.M....Jones K.A. (amp 2007)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55677 HGNC: 25467 AceView: FLJ10006 Ensembl:ENSG00000163166 euGenes: HUgn55677
    ECgene: IWS1 H-InvDB: IWS1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IWS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IWS1 gene:
    Search GeneIP for patents involving IWS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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