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Aliases for IVNS1ABP Gene

Aliases for IVNS1ABP Gene

  • Influenza Virus NS1A Binding Protein 2 3
  • NS1BP 3 4 6
  • Aryl Hydrocarbon Receptor-Associated Protein 3 3 4
  • Kelch-Like Family Member 39 2 3
  • NS1-Binding Protein 3 4
  • FLARA3 3 4
  • NS1-BP 3 4
  • ND1 3 6
  • Aryl Hydrocarbon Receptor-Associated 3 3
  • Influenza Virus NS1A-Binding Protein 3
  • NCX Downstream Gene 1 3
  • KIAA0850 4
  • HSPC068 3
  • KLHL39 3
  • NS-1 3
  • ARA3 4
  • NS1 4

External Ids for IVNS1ABP Gene

Previous GeneCards Identifiers for IVNS1ABP Gene

  • GC01M181785
  • GC01M182504
  • GC01M181997
  • GC01M183532
  • GC01M156501

Summaries for IVNS1ABP Gene

GeneCards Summary for IVNS1ABP Gene

IVNS1ABP (Influenza Virus NS1A Binding Protein) is a Protein Coding gene. Diseases associated with IVNS1ABP include dengue hemorrhagic fever and influenza. Among its related pathways are Influenza A. An important paralog of this gene is GAN.

UniProtKB/Swiss-Prot for IVNS1ABP Gene

  • Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.

Gene Wiki entry for IVNS1ABP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IVNS1ABP Gene

Genomics for IVNS1ABP Gene

Regulatory Elements for IVNS1ABP Gene

Genomic Location for IVNS1ABP Gene

Start:
185,296,388 bp from pter
End:
185,317,339 bp from pter
Size:
20,952 bases
Orientation:
Minus strand

Genomic View for IVNS1ABP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IVNS1ABP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IVNS1ABP Gene

Proteins for IVNS1ABP Gene

  • Protein details for IVNS1ABP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Y0-NS1BP_HUMAN
    Recommended name:
    Influenza virus NS1A-binding protein
    Protein Accession:
    Q9Y6Y0
    Secondary Accessions:
    • A8K8R6
    • Q1G4T6
    • Q1G4T7
    • Q5TF75
    • Q6NW38
    • Q7LCG2
    • Q9NZX0
    • Q9Y480

    Protein attributes for IVNS1ABP Gene

    Size:
    642 amino acids
    Molecular mass:
    71729 Da
    Quaternary structure:
    • Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with AHR/Aryl hydrocarbon receptor.
    SequenceCaution:
    • Sequence=AAF29040.1; Type=Frameshift; Positions=100, 102; Evidence={ECO:0000305}; Sequence=BAA74873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA10029.1; Type=Frameshift; Positions=612; Evidence={ECO:0000305}; Sequence=CAI17867.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IVNS1ABP Gene

Proteomics data for IVNS1ABP Gene at MOPED

Post-translational modifications for IVNS1ABP Gene

  • Ubiquitination at Lys103, Lys197, Lys369, Lys464, and Lys477
  • Modification sites at PhosphoSitePlus

Other Protein References for IVNS1ABP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IVNS1ABP Gene

Domains for IVNS1ABP Gene

Gene Families for IVNS1ABP Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for IVNS1ABP Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6Y0

UniProtKB/Swiss-Prot:

NS1BP_HUMAN :
  • Q9Y6Y0
Domain:
  • When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with IVNS1ABP: view

Function for IVNS1ABP Gene

Molecular function for IVNS1ABP Gene

UniProtKB/Swiss-Prot Function: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.

Gene Ontology (GO) - Molecular Function for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IVNS1ABP: view
genes like me logo Genes that share phenotypes with IVNS1ABP: view

Animal Models for IVNS1ABP Gene

MGI Knock Outs for IVNS1ABP:

miRNA for IVNS1ABP Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IVNS1ABP Gene

Localization for IVNS1ABP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IVNS1ABP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IVNS1ABP Gene COMPARTMENTS Subcellular localization image for IVNS1ABP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IEA --
GO:0005667 transcription factor complex TAS 9696811
GO:0005681 spliceosomal complex TAS 9696811
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with IVNS1ABP: view

Pathways for IVNS1ABP Gene

SuperPathways for IVNS1ABP Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with IVNS1ABP: view

Pathways by source for IVNS1ABP Gene

1 KEGG pathway for IVNS1ABP Gene

Gene Ontology (GO) - Biological Process for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter TAS 9696811
GO:0008380 RNA splicing TAS 9696811
GO:0009615 response to virus TAS 9696811
GO:0016032 viral process IEA --
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with IVNS1ABP: view

Compounds for IVNS1ABP Gene

(1) Novoseek inferred chemical compound relationships for IVNS1ABP Gene

Compound -log(P) Hits PubMed IDs
adenylate 0 7
genes like me logo Genes that share compounds with IVNS1ABP: view

Transcripts for IVNS1ABP Gene

Unigene Clusters for IVNS1ABP Gene

Influenza virus NS1A binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IVNS1ABP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:

ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for IVNS1ABP Gene

GeneLoc Exon Structure for
IVNS1ABP
ECgene alternative splicing isoforms for
IVNS1ABP

Expression for IVNS1ABP Gene

mRNA expression in normal human tissues for IVNS1ABP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IVNS1ABP Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IVNS1ABP Gene

SOURCE GeneReport for Unigene cluster for IVNS1ABP Gene Hs.497183

genes like me logo Genes that share expressions with IVNS1ABP: view

No data available for mRNA Expression by UniProt/SwissProt for IVNS1ABP Gene

Orthologs for IVNS1ABP Gene

This gene was present in the common ancestor of animals.

Orthologs for IVNS1ABP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IVNS1ABP 35
  • 99.79 (n)
  • 99.69 (a)
IVNS1ABP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IVNS1ABP 35
  • 94.39 (n)
  • 97.2 (a)
IVNS1ABP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IVNS1ABP 35
  • 95.53 (n)
  • 97.98 (a)
IVNS1ABP 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ivns1abp 35
  • 93.3 (n)
  • 97.04 (a)
Ivns1abp 16
Ivns1abp 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IVNS1ABP 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IVNS1ABP 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ivns1abp 35
  • 91.83 (n)
  • 96.69 (a)
chicken
(Gallus gallus)
Aves IVNS1ABP 35
  • 82.89 (n)
  • 90.64 (a)
IVNS1ABP 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IVNS1ABP 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4940 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037891 35
  • 78.64 (n)
  • 82.27 (a)
Str.6416 35
zebrafish
(Danio rerio)
Actinopterygii ivns1abpa 35
  • 71.52 (n)
  • 78.25 (a)
ivns1abpa 36
  • 78 (a)
OneToMany
ivns1abpb 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003823 35
  • 47.88 (n)
  • 39.65 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-147 35
  • 46.33 (n)
  • 33.28 (a)
tag-147 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6660 36
  • 27 (a)
ManyToMany
Species with no ortholog for IVNS1ABP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IVNS1ABP Gene

ENSEMBL:
Gene Tree for IVNS1ABP (if available)
TreeFam:
Gene Tree for IVNS1ABP (if available)

Paralogs for IVNS1ABP Gene

Paralogs for IVNS1ABP Gene

genes like me logo Genes that share paralogs with IVNS1ABP: view

Variants for IVNS1ABP Gene

Sequence variations from dbSNP and Humsavar for IVNS1ABP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7123 -- 185,296,579(-) ACACA(A/G)AGAAC utr-variant-3-prime
rs10174 -- 185,297,982(-) GTTAG(C/T)AGAGG utr-variant-3-prime
rs1208517 -- 185,303,351(+) TCCTC(C/T)TTCAA intron-variant
rs1208518 -- 185,310,523(+) AGAAT(C/T)GCTTG intron-variant
rs2273222 -- 185,301,234(+) AATTA(C/T)TACTT intron-variant

Relevant External Links for IVNS1ABP Gene

HapMap Linkage Disequilibrium report
IVNS1ABP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IVNS1ABP Gene

Disorders for IVNS1ABP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for IVNS1ABP Gene including...

Search for IVNS1ABP Gene in MalaCards »

(17) Novoseek inferred disease relationships for IVNS1ABP Gene

Disease -log(P) Hits PubMed IDs
dengue 82.2 43
influenza 77.5 93
flavivirus infections 65.1 1
dengue hemorrhagic fever 64 2
encephalitis japanese 62.4 3

Relevant External Links for IVNS1ABP

Genetic Association Database (GAD)
IVNS1ABP
Human Genome Epidemiology (HuGE) Navigator
IVNS1ABP
genes like me logo Genes that share disorders with IVNS1ABP: view

No data available for UniProtKB/Swiss-Prot for IVNS1ABP Gene

Publications for IVNS1ABP Gene

  1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. (PMID: 9696811) Wolff T. … Palese P. (J. Virol. 1998) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. (PMID: 16582008) Dunham E.E. … Bradfield C.A. (Mol. Pharmacol. 2006) 3 4

Products for IVNS1ABP Gene

Sources for IVNS1ABP Gene

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