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Aliases for IVNS1ABP Gene

Aliases for IVNS1ABP Gene

  • Influenza Virus NS1A Binding Protein 2 3 5
  • Aryl Hydrocarbon Receptor-Associated Protein 3 3 4
  • Kelch-Like Family Member 39 2 3
  • NS1-Binding Protein 3 4
  • FLARA3 3 4
  • NS1-BP 3 4
  • NS1BP 3 4
  • Aryl Hydrocarbon Receptor-Associated 3 3
  • Influenza Virus NS1A-Binding Protein 3
  • NCX Downstream Gene 1 3
  • KIAA0850 4
  • HSPC068 3
  • KLHL39 3
  • NS-1 3
  • ARA3 4
  • ND1 3
  • NS1 4

External Ids for IVNS1ABP Gene

Previous GeneCards Identifiers for IVNS1ABP Gene

  • GC01M181785
  • GC01M182504
  • GC01M181997
  • GC01M183532
  • GC01M185265
  • GC01M156501

Summaries for IVNS1ABP Gene

GeneCards Summary for IVNS1ABP Gene

IVNS1ABP (Influenza Virus NS1A Binding Protein) is a Protein Coding gene. Diseases associated with IVNS1ABP include Influenza and Dengue Disease. Among its related pathways are Influenza A. An important paralog of this gene is KLHL10.

UniProtKB/Swiss-Prot for IVNS1ABP Gene

  • Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.

Gene Wiki entry for IVNS1ABP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IVNS1ABP Gene

Genomics for IVNS1ABP Gene

Regulatory Elements for IVNS1ABP Gene

Enhancers for IVNS1ABP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G185374 1.4 FANTOM5 Ensembl ENCODE 35.6 -58.9 -58867 3.1 PKNOX1 ETV1 TSC22D4 FOSL1 GATA2 RELB FOS IKZF2 STAT1 MTA2 IVNS1ABP RNU7-183P FAM129A SWT1 LOC100422414 RNF2 EDEM3 TRMT1L LOC102724897
GH01G185420 1.3 FANTOM5 Ensembl ENCODE 27.9 -103.5 -103460 1.5 CTCF MTA2 IKZF1 CEBPB FOXP2 IKZF2 TBX21 FAM129A IVNS1ABP SWT1 TRMT1L RNF2 RNU7-183P LOC102724897
GH01G185438 1.6 FANTOM5 Ensembl ENCODE 21.3 -123.8 -123816 4.6 PKNOX1 ATF1 SIN3A GLIS2 GATA2 FOS SP3 TSHZ1 ZNF623 TBX21 IVNS1ABP SWT1 RNF2 MCRIP2P2 ENSG00000279401
GH01G185426 1.2 FANTOM5 Ensembl ENCODE 19 -109.9 -109875 1.8 CTCF RNF2 JUN CEBPB CEBPG RAD21 ZBTB40 GATA3 CBX8 GATA2 IVNS1ABP FAM129A SWT1 RNF2 RNU7-183P LOC102724897
GH01G185483 1.4 FANTOM5 Ensembl ENCODE 14.7 -166.8 -166842 2.0 BACH1 RAD21 ZNF316 HNF4G FOS PRDM10 NFE2 MAFK NFE2L2 RNF2 IVNS1ABP SWT1 RNF2 ENSG00000279401 MCRIP2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IVNS1ABP on UCSC Golden Path with GeneCards custom track

Promoters for IVNS1ABP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017107 1343 4001 CREB3L1 AGO1 DMAP1 YBX1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21

Genomic Location for IVNS1ABP Gene

Chromosome:
1
Start:
185,296,388 bp from pter
End:
185,317,343 bp from pter
Size:
20,956 bases
Orientation:
Minus strand

Genomic View for IVNS1ABP Gene

Genes around IVNS1ABP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IVNS1ABP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IVNS1ABP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IVNS1ABP Gene

Proteins for IVNS1ABP Gene

  • Protein details for IVNS1ABP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Y0-NS1BP_HUMAN
    Recommended name:
    Influenza virus NS1A-binding protein
    Protein Accession:
    Q9Y6Y0
    Secondary Accessions:
    • A8K8R6
    • Q1G4T6
    • Q1G4T7
    • Q5TF75
    • Q6NW38
    • Q7LCG2
    • Q9NZX0
    • Q9Y480

    Protein attributes for IVNS1ABP Gene

    Size:
    642 amino acids
    Molecular mass:
    71729 Da
    Quaternary structure:
    • Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with AHR/Aryl hydrocarbon receptor.
    SequenceCaution:
    • Sequence=AAF29040.1; Type=Frameshift; Positions=100, 102; Evidence={ECO:0000305}; Sequence=BAA74873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA10029.1; Type=Frameshift; Positions=612; Evidence={ECO:0000305}; Sequence=CAI17867.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IVNS1ABP Gene

Post-translational modifications for IVNS1ABP Gene

  • Ubiquitination at posLast=103103, posLast=197197, isoforms=369, isoforms=464, and posLast=477477
  • Modification sites at PhosphoSitePlus

Other Protein References for IVNS1ABP Gene

No data available for DME Specific Peptides for IVNS1ABP Gene

Domains & Families for IVNS1ABP Gene

Gene Families for IVNS1ABP Gene

Suggested Antigen Peptide Sequences for IVNS1ABP Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6Y0

UniProtKB/Swiss-Prot:

NS1BP_HUMAN :
  • When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.
Domain:
  • When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.
genes like me logo Genes that share domains with IVNS1ABP: view

Function for IVNS1ABP Gene

Molecular function for IVNS1ABP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
genes like me logo Genes that share phenotypes with IVNS1ABP: view

Animal Models for IVNS1ABP Gene

MGI Knock Outs for IVNS1ABP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IVNS1ABP Gene

Localization for IVNS1ABP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IVNS1ABP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IVNS1ABP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005667 transcription factor complex TAS 9696811
GO:0005681 spliceosomal complex TAS 9696811
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with IVNS1ABP: view

Pathways & Interactions for IVNS1ABP Gene

SuperPathways for IVNS1ABP Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with IVNS1ABP: view

Pathways by source for IVNS1ABP Gene

1 KEGG pathway for IVNS1ABP Gene

Gene Ontology (GO) - Biological Process for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter TAS 9696811
GO:0008380 RNA splicing TAS 9696811
GO:0009615 response to virus TAS 9696811
GO:0016032 viral process IEA --
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with IVNS1ABP: view

No data available for SIGNOR curated interactions for IVNS1ABP Gene

Drugs & Compounds for IVNS1ABP Gene

(1) Additional Compounds for IVNS1ABP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IVNS1ABP: view

Transcripts for IVNS1ABP Gene

Unigene Clusters for IVNS1ABP Gene

Influenza virus NS1A binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IVNS1ABP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:

ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for IVNS1ABP Gene

GeneLoc Exon Structure for
IVNS1ABP
ECgene alternative splicing isoforms for
IVNS1ABP

Expression for IVNS1ABP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IVNS1ABP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IVNS1ABP Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for IVNS1ABP Gene

This gene is overexpressed in Breast (18.4), Islet of Langerhans (10.2), Placenta (7.4), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IVNS1ABP Gene



Protein tissue co-expression partners for IVNS1ABP Gene

NURSA nuclear receptor signaling pathways regulating expression of IVNS1ABP Gene:

IVNS1ABP

SOURCE GeneReport for Unigene cluster for IVNS1ABP Gene:

Hs.497183

Evidence on tissue expression from TISSUES for IVNS1ABP Gene

  • Nervous system(4.9)
  • Blood(4.2)
  • Skin(3.1)
  • Intestine(2.4)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with IVNS1ABP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IVNS1ABP Gene

Orthologs for IVNS1ABP Gene

This gene was present in the common ancestor of animals.

Orthologs for IVNS1ABP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IVNS1ABP 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia IVNS1ABP 34 35
  • 95.53 (n)
cow
(Bos Taurus)
Mammalia IVNS1ABP 34 35
  • 94.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IVNS1ABP 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ivns1abp 34 16 35
  • 93.3 (n)
rat
(Rattus norvegicus)
Mammalia Ivns1abp 34
  • 91.83 (n)
oppossum
(Monodelphis domestica)
Mammalia IVNS1ABP 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves IVNS1ABP 34 35
  • 82.89 (n)
lizard
(Anolis carolinensis)
Reptilia IVNS1ABP 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037891 34
  • 78.64 (n)
Str.6416 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4940 34
zebrafish
(Danio rerio)
Actinopterygii ivns1abpb 35
  • 74 (a)
OneToMany
ivns1abpa 34 35
  • 71.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003823 34
  • 47.88 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-147 34 35
  • 46.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6660 35
  • 27 (a)
ManyToMany
Species where no ortholog for IVNS1ABP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IVNS1ABP Gene

ENSEMBL:
Gene Tree for IVNS1ABP (if available)
TreeFam:
Gene Tree for IVNS1ABP (if available)

Paralogs for IVNS1ABP Gene

Paralogs for IVNS1ABP Gene

genes like me logo Genes that share paralogs with IVNS1ABP: view

Variants for IVNS1ABP Gene

Sequence variations from dbSNP and Humsavar for IVNS1ABP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000243681 -- 185,293,893(+) AGAAT(C/T)ACCAG utr-variant-3-prime
rs1000379743 -- 185,313,994(+) TTGTT(-/A)AAAAG intron-variant
rs1000578356 -- 185,314,776(+) ATTAT(C/T)AAAAT intron-variant
rs1000642384 -- 185,315,347(+) AATTT(A/G)AAACT intron-variant
rs1000652694 -- 185,319,220(+) ATGGC(C/T)CAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IVNS1ABP Gene

Variant ID Type Subtype PubMed ID
nsv548398 CNV gain 21841781

Variation tolerance for IVNS1ABP Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IVNS1ABP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IVNS1ABP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IVNS1ABP Gene

Disorders for IVNS1ABP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IVNS1ABP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
dengue disease
  • dengue hemorrhagic fever
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IVNS1ABP

Genetic Association Database (GAD)
IVNS1ABP
Human Genome Epidemiology (HuGE) Navigator
IVNS1ABP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IVNS1ABP
genes like me logo Genes that share disorders with IVNS1ABP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IVNS1ABP Gene

Publications for IVNS1ABP Gene

  1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. (PMID: 9696811) Wolff T. … Palese P. (J. Virol. 1998) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 64
  5. The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. (PMID: 16582008) Dunham E.E. … Bradfield C.A. (Mol. Pharmacol. 2006) 3 4 64

Products for IVNS1ABP Gene

Sources for IVNS1ABP Gene

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