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IVNS1ABP Gene

protein-coding   GIFtS: 59
GCID: GC01M185265

Influenza Virus NS1A Binding Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Influenza Virus NS1A Binding Protein1 2     KLHL392
NS1BP2 3 5     NS-12
Kelch-Like Family Member 391 2     Aryl Hydrocarbon Receptor-Associated 32
Aryl Hydrocarbon Receptor-Associated Protein 32 3     Influenza Virus NS1A-Binding Protein2
FLARA32 3     NCX Downstream Gene 12
NS1-BP2 3     ARA33
NS1-Binding Protein2 3     KIAA08503
ND12 5     NS13
HSPC0682     

External Ids:    HGNC: 169511   Entrez Gene: 106252   Ensembl: ENSG000001166797   OMIM: 6092095   UniProtKB: Q9Y6Y03   

Export aliases for IVNS1ABP gene to outside databases

Previous GC identifers: GC01M181785 GC01M182504 GC01M181997 GC01M183532 GC01M156501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IVNS1ABP Gene:
IVNS1ABP (influenza virus NS1A binding protein) is a protein-coding gene. Diseases associated with IVNS1ABP include dengue hemorrhagic fever, and newcastle disease. An important paralog of this gene is GAN.

UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0
Function: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of
actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by
actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the
actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in
cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in
pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as
modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate
transcription

Gene Wiki entry for IVNS1ABP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IVNS1ABP gene promoter:
         Max1   AhR   C/EBPbeta   FOXF2   CUTL1   HNF-3beta   Arnt   HFH-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIVNS1ABP promoter sequence
   Search Chromatin IP Primers for IVNS1ABP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IVNS1ABP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1-q31.1   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.1-q31.1

IVNS1ABP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IVNS1ABP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M185265:  view genomic region     (about GC identifiers)

Start:
185,265,520 bp from pter      End:
185,286,461 bp from pter
Size:
20,942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0 (See protein sequence)
Recommended Name: Influenza virus NS1A-binding protein  
Size: 642 amino acids; 71729 Da
Subunit: Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and
with AHR/Aryl hydrocarbon receptor
Sequence caution: Sequence=AAF29040.1; Type=Frameshift; Positions=100, 102; Sequence=BAA74873.2; Type=Erroneous
initiation; Sequence=CAA10029.1; Type=Frameshift; Positions=612; Sequence=CAI17867.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8K8R6 Q1G4T6 Q1G4T7 Q5TF75 Q6NW38 Q7LCG2 Q9NZX0 Q9Y480

Explore the universe of human proteins at neXtProt for IVNS1ABP: NX_Q9Y6Y0

Explore proteomics data for IVNS1ABP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys197, Lys369, Lys464, Lys477
  • Modification sites at PhosphoSitePlus

  • See IVNS1ABP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006460.2  
    ENSEMBL proteins: 
     ENSP00000356468   ENSP00000401826   ENSP00000356467   ENSP00000375864  

    IVNS1ABP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals IVNS1ABP Protein
    Novus Biologicals IVNS1ABP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IVNS1ABP

    IVNS1ABP Antibody Products:

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    ThermoFisher Antibody for IVNS1ABP
    LSBio Antibodies in human, mouse, rat for IVNS1ABP

    IVNS1ABP Assay Products:

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    Cloud-Clone Corp. ELISAs for IVNS1ABP
    Cloud-Clone Corp. CLIAs for IVNS1ABP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR017096 Kelch-like_gigaxonin-typ
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR015916 Gal_Oxidase_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q9Y6Y0

    ProtoNet protein and cluster: Q9Y6Y0

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0
    Domain: When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus,
    the BTB domain inhibits AHR signaling induced by IVNS1ABP
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    IVNS1ABP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NS1BP_HUMAN, Q9Y6Y0
    Function: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of
    actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by
    actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the
    actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in
    cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in
    pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as
    modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate
    transcription

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IVNS1ABP for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ivns1abp):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  muscle 
     respiratory system 

    IVNS1ABP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ivns1abptm1Htno for IVNS1ABP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IVNS1ABP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IVNS1ABP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IVNS1ABP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IVNS1ABP

    miRNA
    Products:
        
    miRTarBase miRNAs that target IVNS1ABP:
    hsa-mir-103a-3p (MIRT026996), hsa-mir-320a (MIRT044680), hsa-mir-16-5p (MIRT031511), hsa-mir-21-5p (MIRT030741), hsa-mir-26b-5p (MIRT029013)

    Block miRNA regulation of human, mouse, rat IVNS1ABP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IVNS1ABP (see all 34):
    hsa-miR-4291 hsa-miR-548j hsa-miR-765 hsa-let-7a-2* hsa-miR-3167 hsa-miR-548l hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIVNS1ABP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IVNS1ABP
    Predesigned siRNA for gene silencing in human, mouse, rat IVNS1ABP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IVNS1ABP

    Clone
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    OriGene clones in human, mouse for IVNS1ABP (see all 6)
    OriGene ORF clones in mouse, rat for IVNS1ABP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IVNS1ABP (NM_006469)
    Sino Biological Human cDNA Clone for IVNS1ABP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IVNS1ABP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IVNS1ABP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IVNS1ABP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IVNS1ABP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NS1BP_HUMAN, Q9Y6Y0: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin
    filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules
    and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution
    from speckles to a more diffuse distribution in the nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IEA--
    GO:0005667transcription factor complex TAS9696811
    GO:0005681spliceosomal complex TAS9696811
    GO:0005737cytoplasm IDA--

    IVNS1ABP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IVNS1ABP About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for IVNS1ABP):
        Influenza A


    IVNS1ABP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IVNS1ABP
    Interactions:

        GeneGlobe Interaction Network for IVNS1ABP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for IVNS1ABP (Q9Y6Y02, 3 ENSP000003564684) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-65879 I2D: score=5 
    PFN2P350802, 3MINT-65876 I2D: score=5 
    VIMP086702, 3MINT-65878 I2D: score=5 
    CITED4Q96RK13, ENSP000003617214I2D: score=1 STRING: ENSP00000361721
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006383transcription from RNA polymerase III promoter TAS9696811
    GO:0008380RNA splicing TAS9696811
    GO:0009615response to virus TAS9696811
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    IVNS1ABP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IVNS1ABP (NS1BP)

    1 Novoseek inferred chemical compound relationship for IVNS1ABP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 0 9 7908060 (5), 14645908 (2)



    IVNS1ABP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IVNS1ABP gene (2 alternative transcripts): 
    NM_016389.2  NM_006469.4  

    Unigene Cluster for IVNS1ABP:

    Influenza virus NS1A binding protein
    Hs.497183  [show with all ESTs]
    Unigene Representative Sequence: NM_006469
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480769(uc001gri.3 uc001grj.3) ENST00000367498(uc009wyj.3 uc001grl.3 uc009wyk.3)
    ENST00000459929 ENST00000475046 ENST00000494880(uc001grm.3) ENST00000468217
    ENST00000491112 ENST00000422754 ENST00000367497 ENST00000392007
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat IVNS1ABP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IVNS1ABP (see all 34):
    hsa-miR-4291 hsa-miR-548j hsa-miR-765 hsa-let-7a-2* hsa-miR-3167 hsa-miR-548l hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIVNS1ABP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IVNS1ABP
    Clone
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    OriGene ORF clones in mouse, rat for IVNS1ABP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IVNS1ABP (NM_006469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IVNS1ABP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IVNS1ABP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IVNS1ABP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IVNS1ABP
      QuantiTect SYBR Green Assays in human, mouse, rat IVNS1ABP
      QuantiFast Probe-based Assays in human, mouse, rat IVNS1ABP

    Additional mRNA sequence: 

    AB020657.1 AF161553.1 AF205218.1 AJ012449.1 AK000931.1 AK001273.1 AK001625.1 AK001824.1 
    AK023020.1 AK023123.1 AK092912.1 AK093912.1 AK292431.1 AL137640.1 BC067739.1 BX648273.1 
    BX649183.1 DQ443528.1 DQ443529.1 

    Selected DOTS entries (see all 28):

    DT.97799807  DT.218042  DT.95343436  DT.100797934  DT.92452328  DT.218043  DT.121345634  DT.100654815 
    DT.100706613  DT.100797930  DT.95151530  DT.100797937  DT.95151507  DT.99972603  DT.121345597  DT.121345627 
    DT.92452333  DT.95151528  DT.100715503  DT.100797945  DT.121345580  DT.121345624  DT.203810  DT.75154083 

    Selected AceView cDNA sequences (see all 419):

    AU108062 BM719856 CK818773 W31762 BI870413 BQ007647 AI140164 BM678383 
    BQ434960 BM766139 AW014744 BI828622 BQ223839 AA703214 BP369491 CB132599 
    AL137640 BM772429 T48739 BM773383 BX119216 BU735474 BP360894 D19877 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IVNS1ABP (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
    SP1:              -     -                                                                       -     -                 -     -     -     -                 -   
    SP2:              -     -                                                                 -     -     -                 -     -     -     -                 -   
    SP3:                                                                                            -     -                 -     -     -     -                 -   
    SP4:                                                                                                                    -     -     -     -                 -   
    SP5:                                                                                                                    -     -     -     -                 -   

    ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
    SP1:              -                                               -                           
    SP2:              -                                               -                           
    SP3:              -                                               -                           
    SP4:              -                                               -                           
    SP5:              -                             -                 -                           


    ECgene alternative splicing isoforms for IVNS1ABP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IVNS1ABP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACATAC
    IVNS1ABP Expression
    About this image


    IVNS1ABP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    IVNS1ABP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IVNS1ABP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497183
        Custom PCR Arrays for IVNS1ABP
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IVNS1ABP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ivns1abp1 , 5 influenza virus NS1A binding protein1, 5 93.3(n)1
    97.04(a)1
      1 (64.06 cM)5
    1171981  NM_054102.21  NP_473443.21 
     1513444985 
    chicken
    (Gallus gallus)
    Aves IVNS1ABP1 influenza virus NS1A binding protein 82.89(n)
    90.64(a)
      426862  XM_004949879.1  XP_004949936.1 
    lizard
    (Anolis carolinensis)
    Reptilia IVNS1ABP6
    influenza virus NS1A binding protein
    90(a)
    1 ↔ 1
    GL343203.1(3103451-3123862)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.49402 Xenopus laevis transcribed sequence with moderate similarity more 75.88(n)    CA790857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045449.12   -- 75.37(n)    BC045449.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0038231 AgaP_AGAP003823 47.88(n)
    39.65(a)
      1271563  XM_003436581.1  XP_003436629.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1471 tag-147 46.33(n)
    33.28(a)
      181410  NM_077708.5  NP_510109.1 


    ENSEMBL Gene Tree for IVNS1ABP (if available)
    TreeFam Gene Tree for IVNS1ABP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IVNS1ABP gene
    GAN2  KLHDC8B2  KLHL72  IPP2  KLHDC8A2  
    18 SIMAP similar genes for IVNS1ABP using alignment to 3 protein entries:     NS1BP_HUMAN (see all proteins):
    DKFZp686K06216    KLHL22    KEAP1    KLHL3    KLHDC8A    KLHL12
    KLHL23    KLHL21    KLHL8    KLHL2    KLHL30    KLHL5
    KLHL18    DKFZp761P1717    KLHL20    KLHL1    KLHL17    KLHL13

    IVNS1ABP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IVNS1ABP (see all 420)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609206261,2
    C,F--185265041(+) ACCCTG/ACATTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1456682051,2
    --185265071(+) CCACCC/TGAGTA 1 -- ds50010--------
    rs1844691961,2
    --185265072(+) CACCCA/GAGTAT 1 -- ds50010--------
    rs107980041,2
    C,F,A,H--185265149(+) ATTAAA/GTTGAC 1 -- ds500130Minor allele frequency- G:0.41NS EA NA WA CSA 2774
    rs1150267141,2
    C,F--185265159(+) CCAGAA/GGTGTG 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1402481761,2
    C--185265262(+) TCTCC-/CTCTCTG 1 -- ds50010--------
    rs71231,2
    C,F,O,A,H--185265711(-) ACACAA/GAGAAC 1 -- ut3132Minor allele frequency- G:0.49MN NA NS EA WA CSA 3028
    rs763949761,2
    C,F--185265740(+) AGTGGC/TAGAGT 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs1414356891,2
    C--185265806(+) CACTGA/CATAGT 1 -- ut310--------
    rs1869954021,2
    --185265928(+) GGTGAA/GTTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IVNS1ABP (185265520 - 185286461 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IVNS1ABP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IVNS1ABP
    DNA2.0 Custom Variant and Variant Library Synthesis for IVNS1ABP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609209    OMIM disorders: --

    Selected diseases for IVNS1ABP (see all 29):    
    About MalaCards
    dengue hemorrhagic fever    newcastle disease    japanese encephalitis    tick-borne encephalitis
    avian influenza    influenza    encephalitis    dengue shock syndrome
    hemorrhagic fever    arthropathy    west nile virus    echinococcosis
    leber hereditary optic neuropathy    uveitis    vaccinia    thrombocytopenia
    hepatitis c    pulmonary function    arthritis    neuropathy


    IVNS1ABP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for IVNS1ABP gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dengue 82.2 63 10698995 (6), 11825945 (4), 12853395 (3), 18471994 (3) (see all 24)
    influenza 77.5 111 15956587 (5), 19926108 (4), 19369407 (4), 10938102 (4) (see all 47)
    flavivirus infections 65.1 1 11825945 (1)
    dengue hemorrhagic fever 64 2 15878791 (1), 19232392 (1)
    encephalitis japanese 62.4 3 11166901 (2), 15528700 (1)
    encephalitis tick-borne 62.3 3 9304300 (2), 18756813 (1)
    virus infection 52.5 13 12853395 (2), 10698995 (2), 11825945 (1), 19926108 (1) (see all 9)
    secondary infection 47.6 3 11825945 (1), 18448542 (1), 10698995 (1)
    dengue shock syndrome 46.5 1 15878791 (1)
    bluetongue 30.8 1 16282482 (1)

    Genetic Association Database (GAD): IVNS1ABP
    Human Genome Epidemiology (HuGE) Navigator: IVNS1ABP (2 documents)

    Export disorders for IVNS1ABP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IVNS1ABP gene, integrated from 10 sources (see all 156):
    (articles sorted by number of sources associating them with IVNS1ABP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. (PubMed id 9696811)1, 2, 3, 9 Wolff T.... Palese P. (J. Virol. 1998)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    5. The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. (PubMed id 16582008)1, 2 Dunham E.E.... Bradfield C.A. (Mol. Pharmacol. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    9. Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus. (PubMed id 24210102)1 Othumpangat S....Beezhold D.H. (Virology 2013)
    10. Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. (PubMed id 23825951)1 Tsai P.L....Fontoura B.M. (PLoS Pathog. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10625 HGNC: 16951 AceView: IVNS1ABP Ensembl:ENSG00000116679 euGenes: HUgn10625
    ECgene: IVNS1ABP Kegg: 10625 H-InvDB: IVNS1ABP

    (According to HUGE)
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    HUGE: KIAA0850

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IVNS1ABP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IVNS1ABP gene:
    Search GeneIP for patents involving IVNS1ABP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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