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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IVNS1ABP Gene

protein-coding   GIFtS: 55
GCID: GC01M185265

influenza virus NS1A binding protein
 Explore 27 diseases affiliated with
IVNS1ABP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IVNS1ABP    

Aliases
for IVNS1ABP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Influenza Virus NS1A Binding Protein1 2     NS1BP2 3
NS1-BP1 2 3     NS1-Binding Protein2 3
HSPC0681 2     Aryl Hydrocarbon Receptor-Associated 32
KLHL391 2     Influenza Virus NS1A-Binding Protein2
ND11 2     Kelch-Like Family Member 392
NS-11 2     NCX Downstream Gene 12
KIAA08501 3     ARA33
Aryl Hydrocarbon Receptor-Associated Protein 32 3     NS13
FLARA32 3     

External Ids:    HGNC: 169511   Entrez Gene: 106252   Ensembl: ENSG000001166797   OMIM: 6092095   UniProtKB: Q9Y6Y03   

Export aliases for IVNS1ABP gene to outside databases

Previous GC identifers: GC01M181785 GC01M182504 GC01M181997 GC01M183532 GC01M156501


Summaries
for IVNS1ABP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0
Function: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin
filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin
destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing
cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By
similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the
inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor
pathway increasing the concentration of AHR available to activate transcription

Gene Wiki entry for IVNS1ABP


Genomic Views
for IVNS1ABP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IVNS1ABP gene promoter:
         Max1   AhR   C/EBPbeta   FOXF2   CUTL1   HNF-3beta   Arnt   HFH-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IVNS1ABP promoter sequence
   Search SABiosciences Chromatin IP Primers for IVNS1ABP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IVNS1ABP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1-q31.1   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.1-q31.1

IVNS1ABP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IVNS1ABP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M185265:  view genomic region     (about GC identifiers)

Start:
 185,265,520 bp from pter      End:
 185,286,461 bp from pter
Size:
 20,942 bases      Orientation:
 minus strand

Proteins
for IVNS1ABP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0 (See protein sequence)
Recommended Name: Influenza virus NS1A-binding protein  
Size: 642 amino acids; 71729 Da
Subunit: Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with
AHR/Aryl hydrocarbon receptor
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments
(By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched
in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a
more diffuse distribution in the nucleoplasm
Sequence caution: Sequence=AAF29040.1; Type=Frameshift; Positions=100, 102; Sequence=BAA74873.2; Type=Erroneous
initiation; Sequence=CAA10029.1; Type=Frameshift; Positions=612; Sequence=CAI17867.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8K8R6 Q1G4T6 Q1G4T7 Q5TF75 Q6NW38 Q7LCG2 Q9NZX0 Q9Y480

Explore the universe of human proteins at neXtProt for IVNS1ABP: NX_Q9Y6Y0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6Y0

    • IVNS1ABP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006460.2  
    ENSEMBL proteins: 
     ENSP00000356468   ENSP00000401826   ENSP00000356467   ENSP00000375864  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: IVNS1ABP
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    Novus Biologicals IVNS1ABP Protein
    Novus Biologicals IVNS1ABP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IVNS1ABP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex TAS9696811
    GO:0005681spliceosomal complex TAS9696811
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--


    IVNS1ABP for ontologies           About GeneDecksing



    IVNS1ABP Antibody Products: 
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    Uscn Antibodies for IVNS1ABP
    Search ThermoFisher Antibodies for IVNS1ABP

    Assay Products for IVNS1ABP: 
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    Uscn ELISAs and CLIAs for IVNS1ABP

    Protein Domains /
    Families
    for IVNS1ABP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IVNS1ABP for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9Y6Y0

    ProtoNet protein and cluster: Q9Y6Y0

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0
    Domain: When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the
    BTB domain inhibits AHR signaling induced by IVNS1ABP
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Function
    for IVNS1ABP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NS1BP_HUMAN, Q9Y6Y0
    Function: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin
    filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin
    destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing
    cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By
    similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the
    inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor
    pathway increasing the concentration of AHR available to activate transcription

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IVNS1ABP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IVNS1ABP
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate IVNS1ABP (see all 34):
    hsa-miR-4291 hsa-miR-548j hsa-miR-765 hsa-let-7a-2* hsa-miR-3167 hsa-miR-548l hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: IVNS1ABP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IVNS1ABP (see all 6)
    OriGene siRNA: IVNS1ABP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IVNS1ABP

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IVNS1ABP (see all 5)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IVNS1ABP 

    Cell Line
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    Search LifeMap BioReagents cell lines for IVNS1ABP

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IVNS1ABP

    Animal Models:
         Mouse knock-out Ivns1abptm1Htno for IVNS1ABP
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ivns1abp):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  muscle 
     respiratory system 

    IVNS1ABP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IVNS1ABP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Measles
    		Influenza A0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for IVNS1ABP):
        Influenza A


    IVNS1ABP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IVNS1ABP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/27 Interacting proteins for IVNS1ABP (Q9Y6Y02, 3 ENSP000003564684) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-65879 I2D: score=5 
    PFN2P350802, 3MINT-65876 I2D: score=5 
    VIMP086702, 3MINT-65878 I2D: score=5 
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    SYNCRIPO605063, ENSP000003586354I2D: score=1 STRING: ENSP00000358635
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006383transcription from RNA polymerase III promoter TAS9696811
    GO:0008380RNA splicing TAS9696811
    GO:0009615response to virus TAS9696811
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    IVNS1ABP for ontologies           About GeneDecksing



    Drugs & Compounds
    for IVNS1ABP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IVNS1ABP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IVNS1ABP
    1 Novoseek chemical compound relationship for IVNS1ABP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 0 9 7908060 (5), 14645908 (2)

    Search CenterWatch for drugs/clinical trials and news about IVNS1ABP / NS1BP 

    Transcripts
    for IVNS1ABP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IVNS1ABP gene (2 alternative transcripts): 
    NM_016389.2  NM_006469.4  

    Unigene Cluster for IVNS1ABP:

    Influenza virus NS1A binding protein
    Hs.497183  [show with all ESTs]
    Unigene Representative Sequence: NM_006469
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367498(uc009wyj.3 uc001grl.3 uc009wyk.3) ENST00000480769(uc001gri.3 uc001grj.3)
    ENST00000459929 ENST00000475046 ENST00000494880(uc001grm.3) ENST00000468217
    ENST00000491112 ENST00000422754 ENST00000367497 ENST00000392007

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IVNS1ABP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IVNS1ABP
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate IVNS1ABP (see all 34):
    hsa-miR-4291 hsa-miR-548j hsa-miR-765 hsa-let-7a-2* hsa-miR-3167 hsa-miR-548l hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: IVNS1ABP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IVNS1ABP (see all 6)
    OriGene siRNA: IVNS1ABP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IVNS1ABP
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IVNS1ABP
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    GenScript: all cDNA clones in your preferred vector: IVNS1ABP (NM_006469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IVNS1ABP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IVNS1ABP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IVNS1ABP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IVNS1ABP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IVNS1ABP

    Additional cDNA sequence: 

    AB020657.1 AF161553.1 AF205218.1 AJ012449.1 AK000931.1 AK001273.1 AK001625.1 AK001824.1 
    AK023020.1 AK023123.1 AK092912.1 AK093912.1 AK292431.1 AL137640.1 BC067739.1 BX648273.1 
    BX649183.1 DQ443528.1 DQ443529.1 

    24/28 DOTS entries (see all 28):

    DT.97799807  DT.218042  DT.95343436  DT.100797934  DT.92452328  DT.218043  DT.121345634  DT.100654815 
    DT.100706613  DT.100797930  DT.95151530  DT.100797937  DT.95151507  DT.99972603  DT.121345597  DT.121345627 
    DT.92452333  DT.95151528  DT.100715503  DT.100797945  DT.121345580  DT.121345624  DT.203810  DT.75154083 

    24/419 AceView cDNA sequences (see all 419):

    BM794012 AA308190 BM696888 BQ434960 BM676721 BU633423 BM678383 BP355437 
    CK429765 AU130922 AB020657 BX649183 BG571321 AA703214 AA486796 AI470623 
    AU117518 CR621232 CB132599 AI689568 BP360894 W31762 BQ271200 BE858805 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for IVNS1ABP (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
    SP1:              -     -                                                                       -     -                 -     -     -     -                 -   
    SP2:              -     -                                                                 -     -     -                 -     -     -     -                 -   
    SP3:                                                                                            -     -                 -     -     -     -                 -   
    SP4:                                                                                                                    -     -     -     -                 -   
    SP5:                                                                                                                    -     -     -     -                 -   

    ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
    SP1:              -                                               -                           
    SP2:              -                                               -                           
    SP3:              -                                               -                           
    SP4:              -                                               -                           
    SP5:              -                             -                 -                           


    ECgene alternative splicing isoforms for IVNS1ABP

    Expression
    for IVNS1ABP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IVNS1ABP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTACATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IVNS1ABP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See IVNS1ABP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IVNS1ABP

    SOURCE GeneReport for Unigene cluster: Hs.497183
        SABiosciences Custom PCR Arrays for IVNS1ABP
    Primer
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    Orthologs
    for IVNS1ABP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IVNS1ABP gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IVNS1ABP1 influenza virus NS1A binding protein 82.89(n)
    90.64(a)    		   426862  XM_424470.3  XP_424470.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IVNS1ABP6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343203.1(3104849-3118899)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.49402 Xenopus laevis transcribed sequence with moderate similarity more 75.88(n)    CA790857.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC045449.12   -- 75.37(n)    BC045449.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0038231 AGAP003823-PA 47.64(n)
    38.79(a)    		   1271563  XM_310384.6  XP_310384.6 
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1471 Protein TAG-147 46.53(n)
    32.79(a)    		   181410  NM_077708.4  NP_510109.1 


    ENSEMBL Gene Tree for IVNS1ABP (if available)
    TreeFam Gene Tree for IVNS1ABP (if available) 

    Paralogs
    for IVNS1ABP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IVNS1ABP gene
    KLHDC8B2  KLHDC8A2  
    17 SIMAP similar genes for IVNS1ABP using alignment to 3 protein entries:     NS1BP_HUMAN (see all proteins):
    DKFZp686K06216    KLHL22    KEAP1    KLHL3    KLHL12    KLHL21
    KLHL8    KLHL2    KLHL30    KLHL5    KLHL18    DKFZp761P1717
    KLHL20    KLHL1    KLHL17    KLHL13    DKFZp781C1855

    IVNS1ABP for paralogs           About GeneDecksing



    Genomic Variants
    for IVNS1ABP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 NCBI SNPs in IVNS1ABP are shown (see all 328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs609206261,2
    		C,--185265041(+) ACCCTG/ACATTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1456682051,2
    		--185265071(+) CCACCC/TGAGTA 1 -- ds50010--------
    rs1844691961,2
    		--185265072(+) CACCCA/GAGTAT 1 -- ds50010--------
    rs107980041,2
    		C,F,A,H,--185265149(+) ATTAAA/GTTGAC 1 -- ds500130Minor allele frequency- G:0.41NS EA NA WA CSA 2774
    rs1150267141,2
    		--185265159(+) CCAGAA/GGTGTG 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1402481761,2
    		C,--185265262(+) TCTCC-/CTCTCTG 1 -- ds50010--------
    rs71231,2
    		C,F,O,A,H,--185265711(-) ACACAA/GAGAAC 1 -- ut3132Minor allele frequency- G:0.49MN NA NS EA WA CSA 3028
    rs763949761,2
    		C,F,--185265740(+) AGTGGC/TAGAGT 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs1414356891,2
    		--185265806(+) CACTGA/CATAGT 1 -- ut310--------
    rs1869954021,2
    		--185265928(+) GGTGAA/GTTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IVNS1ABP (185265520 - 185286461 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IVNS1ABP: --

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    Disorders / Diseases
    for IVNS1ABP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IVNS1ABP for disorders           About GeneDecksing

    OMIM gene information: 609209    OMIM disorders: --

    20/27 diseases for IVNS1ABP (see all 27):    About MalaCards
    influenza    tick-borne encephalitis    dengue hemorrhagic fever    leber hereditary optic neuropathy
    west nile virus    hemorrhagic fever    dengue shock syndrome    japanese encephalitis
    newcastle disease    avian influenza    encephalitis    arthropathy
    rheumatoid arthritis    hepatitis c    echinococcosis    arthritis
    uveitis    neuropathy    thrombocytopenia    vaccinia

    10/17 Novoseek disease relationships for IVNS1ABP gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dengue 82.2 63 10698995 (6), 11825945 (4), 12853395 (3), 18471994 (3) (see all 24)
    influenza 77.5 111 15956587 (5), 19926108 (4), 19369407 (4), 10938102 (4) (see all 47)
    flavivirus infections 65.1 1 11825945 (1)
    dengue hemorrhagic fever 64 2 15878791 (1), 19232392 (1)
    encephalitis japanese 62.4 3 11166901 (2), 15528700 (1)
    encephalitis tick-borne 62.3 3 9304300 (2), 18756813 (1)
    virus infection 52.5 13 12853395 (2), 10698995 (2), 11825945 (1), 19926108 (1) (see all 9)
    secondary infection 47.6 3 11825945 (1), 18448542 (1), 10698995 (1)
    dengue shock syndrome 46.5 1 15878791 (1)
    bluetongue 30.8 1 16282482 (1)

    Human Genome Epidemiology (HuGE) Navigator: IVNS1ABP (2 documents)

    Export disorders for IVNS1ABP gene to outside databases

    Publications
    for IVNS1ABP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IVNS1ABP gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with IVNS1ABP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. (PubMed id 9696811)1, 2, 3, 9 Wolff T.... Palese P. (1998)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. (PubMed id 16582008)1, 2 Dunham E.E.... Bradfield C.A. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for IVNS1ABP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IVNS1ABP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10625 HGNC: 16951 AceView: IVNS1ABP Ensembl:ENSG00000116679 euGenes: HUgn10625
    ECgene: IVNS1ABP Kegg: 10625 H-InvDB: IVNS1ABP

    Other Databases showing IVNS1ABP gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0850

    Specialized Databases showing IVNS1ABP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IVNS1ABP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IVNS1ABP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IVNS1ABP gene:
    Search GeneIP for patents involving IVNS1ABP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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