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Aliases for IVL Gene

Aliases for IVL Gene

  • Involucrin 2 3

External Ids for IVL Gene

Previous GeneCards Identifiers for IVL Gene

  • GC01P150697
  • GC01P148663
  • GC01P149656
  • GC01P150097
  • GC01P149695
  • GC01P151147
  • GC01P124244

Summaries for IVL Gene

Entrez Gene Summary for IVL Gene

  • Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

GeneCards Summary for IVL Gene

IVL (Involucrin) is a Protein Coding gene. Diseases associated with IVL include senile angioma and clear cell acanthoma. Among its related pathways are Corticotropin-releasing hormone and G-Beta Gamma Signaling. GO annotations related to this gene include structural molecule activity and protein binding, bridging.

UniProtKB/Swiss-Prot for IVL Gene

  • Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia

Gene Wiki entry for IVL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IVL Gene

Genomics for IVL Gene

Regulatory Elements for IVL Gene

Genomic Location for IVL Gene

152,908,545 bp from pter
152,911,886 bp from pter
3,342 bases
Plus strand

Genomic View for IVL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IVL Gene

Proteins for IVL Gene

  • Protein details for IVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T7P4

    Protein attributes for IVL Gene

    585 amino acids
    Molecular mass:
    68479 Da
    Quaternary structure:
    • Directly or indirectly cross-linked to cornifelin (CNFN)

    Three dimensional structures from OCA and Proteopedia for IVL Gene

neXtProt entry for IVL Gene

Proteomics data for IVL Gene at MOPED

Post-translational modifications for IVL Gene

  • Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IVL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IVL Gene

Domains for IVL Gene

Protein Domains for IVL Gene

Suggested Antigen Peptide Sequences for IVL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P07476
  • Belongs to the involucrin family.
genes like me logo Genes that share domains with IVL: view

No data available for Gene Families for IVL Gene

Function for IVL Gene

Molecular function for IVL Gene

GENATLAS Biochemistry:
involucrin,precursor of cornified cell enveloppe (major component of keratinocyte cross-linked enveloppe),SPRR family,cytosol protein ultimately cross-linked to membrane by transglutaminase
UniProtKB/Swiss-Prot Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia

Gene Ontology (GO) - Molecular Function for IVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IDA 10908733
GO:0030674 protein binding, bridging IDA 10908733
genes like me logo Genes that share ontologies with IVL: view

Phenotypes for IVL Gene

MGI mutant phenotypes for IVL:
inferred from 1 alleles
GenomeRNAi human phenotypes for IVL:
genes like me logo Genes that share phenotypes with IVL: view

Animal Models for IVL Gene

MGI Knock Outs for IVL:

miRNA for IVL Gene

miRTarBase miRNAs that target IVL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IVL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IVL Gene

Localization for IVL Gene

Subcellular locations from UniProtKB/Swiss-Prot for IVL Gene

Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.

Subcellular locations from

Jensen Localization Image for IVL Gene COMPARTMENTS Subcellular localization image for IVL gene
Compartment Confidence
cytoskeleton 5
cytosol 3
golgi apparatus 3
extracellular 2
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0005737 cytoplasm IDA 16639001
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with IVL: view

Pathways for IVL Gene

genes like me logo Genes that share pathways with IVL: view

Pathways by source for IVL Gene

Gene Ontology (GO) - Biological Process for IVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010224 response to UV-B IDA 16639001
GO:0018149 peptide cross-linking IDA 10908733
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine TAS 1601889
GO:0030216 keratinocyte differentiation IDA 10908733
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with IVL: view

Compounds for IVL Gene

(87) Novoseek inferred chemical compound relationships for IVL Gene

Compound -log(P) Hits PubMed IDs
calcipotriol 61.8 3
ceramides 60.5 4
retinoic acid 56.3 23
1,25 dihydroxy vitamin d3 53.1 8
ro 31 8220 53 2
genes like me logo Genes that share compounds with IVL: view

Transcripts for IVL Gene

mRNA/cDNA for IVL Gene

(17) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IVL Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IVL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IVL Gene

No ASD Table

Relevant External Links for IVL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IVL Gene

mRNA expression in normal human tissues for IVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IVL Gene

This gene is overexpressed in Esophagus - Mucosa (13.5), Vagina (9.9), Cervix - Ectocervix (8.8), Minor Salivary Gland (7.7), Skin - Not Sun Exposed (Suprapubic) (6.9), and Skin - Sun Exposed (Lower leg) (5.1).

Protein differential expression in normal tissues for IVL Gene

This gene is overexpressed in Cervix (28.1), Esophagus (9.8), Oral epithelium (9.3), and Saliva (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IVL Gene

SOURCE GeneReport for Unigene cluster for IVL Gene Hs.516439

mRNA Expression by UniProt/SwissProt for IVL Gene

Tissue specificity: Keratinocytes of epidermis and other stratified squamous epithelia
genes like me logo Genes that share expressions with IVL: view

Expression partners for IVL Gene

In Situ Assay Products

Orthologs for IVL Gene

This gene was present in the common ancestor of mammals.

Orthologs for IVL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IVL 35
  • 97 (n)
  • 94.12 (a)
IVL 36
  • 94 (a)
(Mus musculus)
Mammalia Ivl 16
Ivl 36
  • 28 (a)
(Bos Taurus)
Mammalia IVL 36
  • 37 (a)
(Canis familiaris)
Mammalia IVL 36
  • 48 (a)
Species with no ortholog for IVL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IVL Gene

Gene Tree for IVL (if available)
Gene Tree for IVL (if available)

Paralogs for IVL Gene

No data available for Paralogs for IVL Gene

Variants for IVL Gene

Sequence variations from dbSNP and Humsavar for IVL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs913996 -- 152,911,635(-) CCTAG(C/T)GGACC utr-variant-3-prime
rs1854778 -- 152,908,247(-) TGCTC(C/T)GAATC upstream-variant-2KB
rs1854779 -- 152,908,196(-) AGGCC(A/G)AAAGA upstream-variant-2KB
rs2229496 - 152,910,134(+) AGAAA(A/G)CACAA reference, missense
rs3820136 -- 152,911,962(-) GGGCC(A/G)TGGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IVL Gene

Variant ID Type Subtype PubMed ID
dgv131e1 CNV Complex 17122850
nsv831592 CNV Gain 17160897
esv29281 CNV Loss 19812545

Relevant External Links for IVL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IVL Gene

Disorders for IVL Gene

(63) Novoseek inferred disease relationships for IVL Gene

Disease -log(P) Hits PubMed IDs
parakeratosis 74.8 5
psoriasis 70.3 13
carcinoma squamous cell 68.9 32
skin diseases 62.8 5
porokeratosis 57.9 2

Relevant External Links for IVL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IVL: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IVL Gene

Publications for IVL Gene

  1. Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope. (PMID: 1601889) Yaffe M.B. … Eckert R.L. (J. Biol. Chem. 1992) 3 4 23
  2. Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. (PMID: 9651377) Marekov L.N. … Steinert P.M. (J. Biol. Chem. 1998) 3 4 23
  3. Structure and evolution of the human involucrin gene. (PMID: 2873896) Eckert R.L. … Green H. (Cell 1986) 2 3 4
  4. Identification and characterization of a novel component of the cornified envelope, cornifelin. (PMID: 15147942) Michibata H. … Imai Y. (Biochem. Biophys. Res. Commun. 2004) 3 4
  5. The glutamine residues reactive in transglutaminase-catalyzed cross- linking of involucrin. (PMID: 2461365) Simon M. … Green H. (J. Biol. Chem. 1988) 3 4

Products for IVL Gene

Sources for IVL Gene

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