External Ids for IVL Gene
Previous GeneCards Identifiers for IVL Gene
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
GeneCards Summary for IVL Gene
IVL (Involucrin) is a Protein Coding gene. Diseases associated with IVL include Porokeratosis and Skin Disease. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Corticotropin-releasing hormone. GO annotations related to this gene include structural molecule activity and protein binding, bridging.
UniProtKB/Swiss-Prot for IVL Gene
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.