ITSN2 Gene
protein-coding GIFtS: 57
GCID: GC02M024425
|
|
intersectin 2(Previous name: SH3 domain protein 1B )
(Previous symbol: SH3D1B)
| |
Aliases
for ITSN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Intersectin 21 2 | | SWA1 2 | | SH3D1B1 2 3 5 | | SH3 Domain-Containing Protein 1B2 3 | | SWAP1 2 3 5 | | SH3P18-Like WASP-Associated Protein2 3 | | SH3P181 2 3 | | SH3 Domain Protein 1B1 | | KIAA12561 3 5 | | Intersectin-21 | | PRO20151 2 | | |
Export aliases for ITSN2 gene to outside databasesPrevious GC identifers: GC02M024341 GC02M024518 GC02M024400 GC02M024337 GC02M024164 |
Summaries
for ITSN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ITSN2:
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteinsinvolved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coatedvesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively splicedtranscript variants have been found for this gene that encode three distinct isoforms. Additional variants have beenfound but their full length nature has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ITSN2_HUMAN, Q9NZM3Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assemblymachinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturationincluding invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR)
Gene Wiki entry for ITSN2
|
Genomic Views
for ITSN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ITSN2 gene promoter:
RelA AP-4 STAT5A Arnt GATA-2 Evi-1 Roaz PPAR-gamma1 PPAR-gamma2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ITSN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITSN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2pter-p25.1 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2pter-p25.1ITSN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M024425: view genomic region
(about GC identifiers)
Start:
|
24,425,733 bp from pter |
End:
|
24,583,583 bp from pter |
Size:
|
157,851 bases |
Orientation:
|
minus strand |
|
Proteins
for ITSN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ITSN2_HUMAN, Q9NZM3 (See
protein sequence)Recommended Name: Intersectin-2 Size: 1697 amino acids; 193461 Da
Subunit: Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according tothe step in the endocytic process. Interacts with ADAM15. Interacts with FASLG. Interacts with ANKRD54 (Bysimilarity). Interacts with FCHO2
Subcellular location: Cytoplasm
Miscellaneous: Overexpression results in the inhibition of the transferrin uptake and the blockage of theclathrin-mediated endocytosis
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Caution: Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2 suggesting apartially overlapping role of the EH domain-containing proteins (PubMed:22648170)
Sequence caution: Sequence=AAF59903.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAF59904.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF63600.1;Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA86570.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
6/7 PDB 3D structures from  and Proteopedia  for ITSN2 (see all 7):1J3T (3D)
1UDL (3D)
1UE9 (3D)
1UFF (3D)
1UHF (3D)
3GF9 (3D)
Secondary accessions: O95062 Q15812 Q9HAK4 Q9NXE6 Q9NYG0 Q9NZM2 Q9ULG4Alternative splicing: 4 isoforms: Q9NZM3-1 Q9NZM3-2 Q9NZM3-3 Q9NZM3-4 (Ref.1 (AAF59904) sequence is in conflict in position: 1235:R->W)Explore the universe of human proteins at neXtProt for ITSN2: NX_Q9NZM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZM3
ITSN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_006268.2 NP_062541.3 NP_671494.2
ENSEMBL proteins: ENSP00000354561 ENSP00000347244 ENSP00000395682 ENSP00000411319 ENSP00000384499 ENSP00000389013 ENSP00000391224 ENSP00000391715 ENSP00000370250
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
ITSN2 for ontologies About GeneDecksing
ITSN2 Antibody Products:
Assay Products for ITSN2: |
Protein
Domains /
Families
for ITSN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ITSN2 for domains About GeneDecksing
5/14 InterPro domains/families (see all 14):Graphical View of Domain Structure for InterPro Entry Q9NZM3ProtoNet protein and cluster: Q9NZM3 5 Blocks protein families: IPB000008 C2 domain IPB000219 DH domain IPB000261 EPS15 homology (EH) IPB001849 Pleckstrin-like IPB011511 Variant SH3
UniProtKB/Swiss-Prot: ITSN2_HUMAN, Q9NZM3Similarity: Contains 1 C2 domainSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 EF-hand domainSimilarity: Contains 2 EH domainsSimilarity: Contains 1 PH domainSimilarity: Contains 5 SH3 domains |
Function
for ITSN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ITSN2_HUMAN, Q9NZM3Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assemblymachinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturationincluding invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ITSN2 (NM_006277) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITSN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITSN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITSN2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ITSN2 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for ITSN2:
|
Pathways & Interactions
for ITSN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of CDC42 activity | |
1  BioSystems Pathway for ITSN2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITSN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/111 Interacting proteins for ITSN2 (Q9NZM32, 3 ENSP000003472444) via UniProtKB, MINT, STRING, and/or I2D (see all 111)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006897 | endocytosis |
IEA | -- | | GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- |
ITSN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ITSN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ITSN2
Search CenterWatch for drugs/clinical trials and news about ITSN2
|
Transcripts
for ITSN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ITSN2 gene (3 alternative transcripts): NM_006277.2 NM_019595.3 NM_147152.2 Unigene Cluster for ITSN2: Intersectin 2 Hs.432562 [show with all ESTs]Unigene Representative Sequence: NM_00627713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478720 ENST00000361999 ENST00000355123(uc002rfe.2) ENST00000427234
ENST00000449392 ENST00000479575 ENST00000406921(uc002rfg.3) ENST00000416160(uc002rfh.1)
ENST00000412011 ENST00000469848 ENST00000443927 ENST00000407704 ENST00000380868(uc002rff.2 uc010eyd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ITSN2 (NM_006277) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITSN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITSN2 |
Additional cDNA sequence: AB033082.1 AF001630.1 AF038189.1 AF182198.1 AF182199.1 AF248540.1 AK000302.1 AK021545.1 AK025400.1 AK091859.1 AK096750.1 AK097890.1 AK127858.1 BC020921.2 BC038963.1 BC146779.1 U61167.1 17 DOTS entries: DT.113819 DT.92414525 DT.99993481 DT.91761251 DT.95269732 DT.100024497 DT.100784242 DT.86841735 DT.99930496 DT.437856 DT.433395 DT.95182304 DT.40203830 DT.65284450 DT.91989488 DT.40130526 DT.95074676 24/235 AceView cDNA sequences (see all 235): NM_147152 F03531 F10868 NM_019595 AI869146 AF248540 AW664162 AI572783 AA873595 AI078087 AB033082 Z40060 AA336981 AI439613 AW183595 CA388981 AI422164 BQ574640 AI580878 AW072850 BU617470 AI285232 CD517111 R57124
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ITSN2 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37 | ^ | 38a | · | 38b | ^ | 39a | · | 39b | ^ | 40 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ITSN2
|
Expression
for ITSN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ITSN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ITSN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITSN2
SOURCE GeneReport for Unigene cluster: Hs.432562
UniProtKB/Swiss-Prot: ITSN2_HUMAN, Q9NZM3Tissue specificity: Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver
SABiosciences Custom PCR Arrays for ITSN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITSN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITSN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITSN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITSN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITSN2 |
Orthologs
for ITSN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ITSN2 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ITSN21 |
intersectin 2 |
78.08(n)
83.35(a) |
|
421979 XM_419989.3 XP_419989.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ITSN26 |
-- |
80(a) |
1 ↔ 1 |
1(137666967-137738311) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.60132 |
Transcribed sequence with moderate similarity to protein more |
76.95(n) |
|
CF348142.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dap1603 |
neurotransmitter secretion |
28(a) |
|
39A4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y116A8C.363 |
-- |
26(a) |
|
IV(17119830-17122230) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G207606AT1G216306 |
calcium-binding EF-hand-containing protein |
9(a)8(a) |
many ↔ manymany ↔ many |
1(7209369-7214993) 1(7581084-7588151) |
rice
(Oryza sativa) |
Liliopsida |
---- |
EF hand family protein, putative, expressed |
9(a)7(a) |
many ↔ manymany ↔ many |
3(1719030-1726903) 6(31012733-31020756) |
ENSEMBL Gene Tree for ITSN2 (if available)
TreeFam Gene Tree for ITSN2 (if available) |
Paralogs
for ITSN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ITSN2 gene
- EPS15L12 EHD32 EHD22 EHD12 EHD42 ITSN12 EPS152 SRL2
18/22 SIMAP similar genes for ITSN2 using alignment to 9 protein entries: ITSN2_HUMAN (see all proteins)
(see all similar genes):GRAP GRB2 GRAP2 SH3GL2 FYN ITSN1
GRAPL ARHGEF7 ABI2 DKFZp686J17173 ABI1 AHI1
ASAP1 MAP3K9 SH3GL1 REPS1 STAM ARHGEF16
ITSN2 for paralogs About GeneDecksing
|
Genomic Variants
for ITSN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ITSN2 (24425733 - 24583583 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ITSN2
1 CNV: 35800
1 Indel: 26644
Human Gene Mutation Database (HGMD): ITSN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITSN2 |
|
Disorders
/ Diseases
for ITSN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ITSN2 for disorders About GeneDecksing
OMIM gene information: 604464
OMIM disorders: --
11  diseases for ITSN2: About MalaCardsfactor xi deficiency wiskott-aldrich syndrome atopic dermatitis kaposi's sarcoma
schistosomiasis dermatitis spasticity sarcoma
schizophrenia pancreatic cancer pancreatitis
Human Genome Epidemiology (HuGE) Navigator: ITSN2 (2 documents)
Export disorders for ITSN2 gene to outside databases
|
Publications
for ITSN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ITSN2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ITSN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Intersectin 2, a new multimodular protein involved in clathrin- mediated endocytosis. (PubMed id 10922467)1, 2, 3, 9 Pucharcos C.... de la Luna S. (2000)
- The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. (PubMed id 11748279)1, 3, 9 McGavin M.K....Siminovitch K.A. (2001)
- The human intersectin genes and their spliced variants are differentially expressed. (PubMed id 11690630)1, 2, 9 Pucharcos C.... de la Luna S. (2001)
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
- Cloning of ligand targets: systematic isolation of SH3 domain- containing proteins. (PubMed id 9630982)1, 2 Sparks A.B.... Kay B.K. (1996)
- Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain. (PubMed id 17390067)1, 9 Seifert M....Welter C. (2007)
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External Searches for ITSN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ITSN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ITSN2 gene
(According to HUGE)
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Specialized Databases showing ITSN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ITSN2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ITSN2 gene:
Search GeneIP for patents involving ITSN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ITSN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ITSN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITSN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITSN2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ITSN2 | | OriGene 3'-UTR Clone for ITSN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITSN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ITSN2 | | OriGene Custom Protein Services for ITSN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITSN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITSN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITSN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITSN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITSN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITSN2 |
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| | | | Search Tocris compounds for ITSN2 |
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 | | | ITSN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITSN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ITSN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITSN2 |
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