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ITPRIPL2 Gene

protein-coding   GIFtS: 43
GCID: GC16P019125

Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like...

(Previous name: inositol 1,4,5-triphosphate receptor interacting protein-like...)
  Search for ITPRIPL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 21 2
Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 21 2
Inositol 1,4,5-Triphosphate Receptor-Interacting Protein-Like 22
Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 22

External Ids:    HGNC: 272571   Entrez Gene: 1620732   Ensembl: ENSG000002057307   UniProtKB: Q3MIP13   

Export aliases for ITPRIPL2 gene to outside databases

Previous GC identifers: GC16P019032 GC16P017662


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ITPRIPL2 Gene:
ITPRIPL2 (inositol 1,4,5-trisphosphate receptor interacting protein-like 2) is a protein-coding gene. An important paralog of this gene is ITPRIP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITPRIPL2 gene promoter:
         AhR   Elk-1   SREBP-1c   Lmo2   MIF-1   SREBP-1b   C/EBPalpha   AREB6   SREBP-1a   NRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITPRIPL2 promoter sequence
   Search Chromatin IP Primers for ITPRIPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITPRIPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

ITPRIPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITPRIPL2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019125:  view genomic region     (about GC identifiers)

Start:
19,125,254 bp from pter      End:
19,132,952 bp from pter
Size:
7,699 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ITPRIPL2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IPIL2_HUMAN, Q3MIP1 (See protein sequence)
Recommended Name: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 precursor  
Size: 535 amino acids; 58446 Da

Explore the universe of human proteins at neXtProt for ITPRIPL2: NX_Q3MIP1

Explore proteomics data for ITPRIPL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ITPRIPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001030013.1  
    ENSEMBL proteins: 
     ENSP00000455257   ENSP00000370849  

    ITPRIPL2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for ITPRIPL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024798 IP3R-int-like_2
     IPR026250 INOS145TPRIP
     IPR024810 Mab-21_dom

    Graphical View of Domain Structure for InterPro Entry Q3MIP1

    ProtoNet protein and cluster: Q3MIP1

    UniProtKB/Swiss-Prot: IPIL2_HUMAN, Q3MIP1
    Similarity: Belongs to the ITPRIP family


    Find genes that share domains with ITPRIPL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITPRIPL2
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    miRNA
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    hsa-mir-615-3p (MIRT040116), hsa-mir-30a-5p (MIRT049933)

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    Selected qRT-PCR Assays for microRNAs that regulate ITPRIPL2 (see all 107):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPIL2_HUMAN, Q3MIP1: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ITPRIPL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITPRIPL2
    Interactions:

        Search GeneGlobe Interaction Network for ITPRIPL2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITPRIPL2 (IPIL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITPRIPL2 gene: 
    NM_001034841.3  

    Unigene Cluster for ITPRIPL2:

    Inositol 1,4,5-trisphosphate receptor interacting protein-like 2
    Hs.530899  [show with all ESTs]
    Unigene Representative Sequence: NM_001034841
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566735(uc002dft.3) ENST00000381440(uc002dfu.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ITPRIPL2 (see all 107):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ITPRIPL2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIPL2
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      QuantiTect SYBR Green Assays in human, mouse, rat ITPRIPL2
      QuantiFast Probe-based Assays in human, mouse, rat ITPRIPL2

    Additional mRNA sequence: 

    AK024121.1 AK026647.1 AK096327.1 AK097274.1 BC015343.2 BC101749.1 BC101751.1 NR_028028.1 

    7 DOTS entries:

    DT.107650  DT.100018742  DT.91953458  DT.305832  DT.456172  DT.431960  DT.91739400 

    1 AceView cDNA sequence:

    AK096327 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITPRIPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTCATTT
    ITPRIPL2 Expression
    About this image


    ITPRIPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    ITPRIPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITPRIPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530899
        Custom PCR Arrays for ITPRIPL2
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    QuantiFast Probe-based Assays in human, mouse, rat ITPRIPL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITPRIPL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itpripl21 , 5 inositol 1,4,5-triphosphate receptor interacting protein-like more1, 5 83.55(n)1
    85.61(a)1
      7 (63.44 cM)5
    3196221  NM_001033380.31  NP_001028552.11 
     1184851145 
    chicken
    (Gallus gallus)
    Aves ITPRIPL21 inositol 1,4,5-trisphosphate receptor interacting protein-like more 64.81(n)
    55.9(a)
      771589  XM_003642123.2  XP_003642171.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITPRIPL26
    inositol 1,4,5-trisphosphate receptor interacting ...
    34(a)
    1 ↔ 1
    GL344017.1(26188-27540)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itpripl21 inositol 1,4,5-trisphosphate receptor interacting protein-like more 51.87(n)
    43.78(a)
      100493371  XM_002932220.2  XP_002932266.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5556281 inositol 1,4,5-trisphosphate receptor-interacting protein-like more 51.88(n)
    44.16(a)
      555628  XM_678195.6  XP_683287.5 


    ENSEMBL Gene Tree for ITPRIPL2 (if available)
    TreeFam Gene Tree for ITPRIPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITPRIPL2 gene
    ITPRIP2  ITPRIPL12  

    Find genes that share paralogs with ITPRIPL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITPRIPL2 (see all 230)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925589561,2
    --19123296(+) TGCCAC/TTGCAC 2 -- us2k10--------
    rs1845498901,2
    --19123528(+) TAGATG/TCAGCT 2 -- us2k10--------
    rs1410124361,2
    C--19123579(+) AATAA-/TGTGTGT 2 -- us2k10--------
    rs767332781,2
    C,F--19123587(+) GTGTGT/CGTGTG 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs583948431,2
    C--19123588(+) TGTGTG/CTGTGT 2 -- us2k14Minor allele frequency- C:0.15CSA WA NA EA 360
    rs1881672511,2
    --19123657(+) CTAAGA/GATCTT 2 -- us2k10--------
    rs1810684481,2
    --19123764(+) ACAACC/TCAGAA 2 -- us2k10--------
    rs596518601,2
    C,F--19123968(+) GACTGA/GGGTTC 2 -- us2k14Minor allele frequency- G:0.20WA CSA 124
    rs740115151,2
    C,F--19123998(+) GGACCC/TCCAAA 2 -- us2k13Minor allele frequency- T:0.21WA CSA 122
    rs124442501,2
    C,F,H--19124414(+) CTCTGG/ATTTCC 2 -- us2k1 tfbs319Minor allele frequency- A:0.19NS EA NA WA CSA 2226

    HapMap Linkage Disequilibrium report for ITPRIPL2 (19125254 - 19132952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITPRIPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    esv587CNV CNV17122850
    dgv823e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITPRIPL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ITPRIPL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ITPRIPL2           About GenesLikeMe

    Genetic Association Database (GAD): ITPRIPL2

    Export disorders for ITPRIPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITPRIPL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ITPRIPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. (PubMed id 21876473)4 Lydall G.J....Gurling H.M. (Psychiatr. Genet. 2011)
    2. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 162073 HGNC: 27257 AceView: LOC162073 Ensembl:ENSG00000205730 euGenes: HUgn162073
    ECgene: ITPRIPL2 H-InvDB: ITPRIPL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITPRIPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITPRIPL2 gene:
    Search GeneIP for patents involving ITPRIPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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