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Aliases for ITPRIPL2 Gene

Aliases for ITPRIPL2 Gene

  • Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 2 2 3
  • Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 2 2

External Ids for ITPRIPL2 Gene

Previous GeneCards Identifiers for ITPRIPL2 Gene

  • GC16P019032
  • GC16P019125
  • GC16P017662

Summaries for ITPRIPL2 Gene

GeneCards Summary for ITPRIPL2 Gene

ITPRIPL2 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 2) is a Protein Coding gene. An important paralog of this gene is ITPRIP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPRIPL2 Gene

Genomics for ITPRIPL2 Gene

Regulatory Elements for ITPRIPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPRIPL2 Gene

Chromosome:
16
Start:
19,113,932 bp from pter
End:
19,121,630 bp from pter
Size:
7,699 bases
Orientation:
Plus strand

Genomic View for ITPRIPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPRIPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPRIPL2 Gene

Proteins for ITPRIPL2 Gene

  • Protein details for ITPRIPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIP1-IPIL2_HUMAN
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
    Protein Accession:
    Q3MIP1

    Protein attributes for ITPRIPL2 Gene

    Size:
    535 amino acids
    Molecular mass:
    58446 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ITPRIPL2 Gene

Proteomics data for ITPRIPL2 Gene at MOPED

Post-translational modifications for ITPRIPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPRIPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITPRIPL2 Gene

Domains & Families for ITPRIPL2 Gene

Protein Domains for ITPRIPL2 Gene

Suggested Antigen Peptide Sequences for ITPRIPL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q3MIP1

UniProtKB/Swiss-Prot:

IPIL2_HUMAN :
  • Belongs to the ITPRIP family.
Family:
  • Belongs to the ITPRIP family.
genes like me logo Genes that share domains with ITPRIPL2: view

No data available for Gene Families for ITPRIPL2 Gene

Function for ITPRIPL2 Gene

Phenotypes for ITPRIPL2 Gene

GenomeRNAi human phenotypes for ITPRIPL2:
genes like me logo Genes that share phenotypes with ITPRIPL2: view

Animal Model Products

CRISPR Products

miRNA for ITPRIPL2 Gene

miRTarBase miRNAs that target ITPRIPL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPRIPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ITPRIPL2 Gene

Localization for ITPRIPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPRIPL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITPRIPL2 Gene COMPARTMENTS Subcellular localization image for ITPRIPL2 gene
Compartment Confidence
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ITPRIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITPRIPL2: view

Pathways & Interactions for ITPRIPL2 Gene

SuperPathways for ITPRIPL2 Gene

No Data Available

Interacting Proteins for ITPRIPL2 Gene

Gene Ontology (GO) - Biological Process for ITPRIPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ITPRIPL2 Gene

Drugs & Compounds for ITPRIPL2 Gene

No Compound Related Data Available

Transcripts for ITPRIPL2 Gene

mRNA/cDNA for ITPRIPL2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITPRIPL2 Gene

Inositol 1,4,5-trisphosphate receptor interacting protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPRIPL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIPL2 Gene

No ASD Table

Relevant External Links for ITPRIPL2 Gene

GeneLoc Exon Structure for
ITPRIPL2
ECgene alternative splicing isoforms for
ITPRIPL2

Expression for ITPRIPL2 Gene

mRNA expression in normal human tissues for ITPRIPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITPRIPL2 Gene

This gene is overexpressed in Placenta (59.8) and Urine (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITPRIPL2 Gene



SOURCE GeneReport for Unigene cluster for ITPRIPL2 Gene Hs.530899

genes like me logo Genes that share expression patterns with ITPRIPL2: view

Protein tissue co-expression partners for ITPRIPL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ITPRIPL2 Gene

Orthologs for ITPRIPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITPRIPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITPRIPL2 35
  • 87.03 (n)
  • 89.1 (a)
ITPRIPL2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITPRIPL2 35
  • 86.65 (n)
  • 88.91 (a)
ITPRIPL2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpripl2 35
  • 83.55 (n)
  • 85.61 (a)
Itpripl2 16
Itpripl2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITPRIPL2 35
  • 99.81 (n)
  • 100 (a)
ITPRIPL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itpripl2 35
  • 82.49 (n)
  • 85.05 (a)
oppossum
(Monodelphis domestica)
Mammalia ITPRIPL2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITPRIPL2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITPRIPL2 35
  • 64.81 (n)
  • 55.9 (a)
lizard
(Anolis carolinensis)
Reptilia ITPRIPL2 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itpripl2 35
  • 51.87 (n)
  • 43.78 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC555628 35
  • 51.88 (n)
  • 44.16 (a)
ITPRIPL2 36
  • 40 (a)
OneToOne
Species with no ortholog for ITPRIPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITPRIPL2 Gene

ENSEMBL:
Gene Tree for ITPRIPL2 (if available)
TreeFam:
Gene Tree for ITPRIPL2 (if available)

Paralogs for ITPRIPL2 Gene

Paralogs for ITPRIPL2 Gene

genes like me logo Genes that share paralogs with ITPRIPL2: view

Variants for ITPRIPL2 Gene

Sequence variations from dbSNP and Humsavar for ITPRIPL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3210530 -- 19,116,726(-) GGAAG(C/T)TTCTC utr-variant-3-prime, nc-transcript-variant
rs3743955 -- 19,121,125(+) GATAA(A/C)GCATG utr-variant-3-prime, nc-transcript-variant
rs3743956 -- 19,121,458(+) ACAAT(C/T)GTATG utr-variant-3-prime, nc-transcript-variant
rs3760088 -- 19,118,689(+) GTGAA(G/T)TTTTA utr-variant-3-prime, nc-transcript-variant
rs3826249 -- 19,121,842(+) TGCTA(C/T)AGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ITPRIPL2 Gene

Variant ID Type Subtype PubMed ID
esv587 CNV CNV 17122850
dgv823e1 CNV Complex 17122850
nsv436835 CNV Insertion 17901297

Variation tolerance for ITPRIPL2 Gene

Residual Variation Intolerance Score: 74.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITPRIPL2 Gene

HapMap Linkage Disequilibrium report
ITPRIPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPRIPL2 Gene

Disorders for ITPRIPL2 Gene

Relevant External Links for ITPRIPL2

Genetic Association Database (GAD)
ITPRIPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITPRIPL2
genes like me logo Genes that share disorders with ITPRIPL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPRIPL2 Gene

Publications for ITPRIPL2 Gene

  1. Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. (PMID: 21876473) Lydall G.J. … Gurling H.M. (Psychiatr. Genet. 2011) 67
  2. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ITPRIPL2 Gene

Sources for ITPRIPL2 Gene

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