Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ITPRIPL1 Gene

Aliases for ITPRIPL1 Gene

  • Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1 2 3
  • Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1 2 3
  • KIAA1754L 3 4
  • Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 1 3
  • Inositol 1,4,5-Triphosphate Receptor-Interacting Protein-Like 1 3
  • KIAA1754-Like 2

External Ids for ITPRIPL1 Gene

Previous HGNC Symbols for ITPRIPL1 Gene

  • KIAA1754L

Previous GeneCards Identifiers for ITPRIPL1 Gene

  • GC02P096991
  • GC02P090952

Summaries for ITPRIPL1 Gene

GeneCards Summary for ITPRIPL1 Gene

ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) is a Protein Coding gene. An important paralog of this gene is ITPRIPL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPRIPL1 Gene

Genomics for ITPRIPL1 Gene

Regulatory Elements for ITPRIPL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPRIPL1 Gene

Start:
96,325,324 bp from pter
End:
96,330,517 bp from pter
Size:
5,194 bases
Orientation:
Plus strand

Genomic View for ITPRIPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPRIPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPRIPL1 Gene

Proteins for ITPRIPL1 Gene

  • Protein details for ITPRIPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GPH6-IPIL1_HUMAN
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
    Protein Accession:
    Q6GPH6
    Secondary Accessions:
    • F5H1L8
    • Q8NE61

    Protein attributes for ITPRIPL1 Gene

    Size:
    555 amino acids
    Molecular mass:
    63395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITPRIPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITPRIPL1 Gene

Proteomics data for ITPRIPL1 Gene at MOPED

Post-translational modifications for ITPRIPL1 Gene

  • Ubiquitination at Lys274
  • Modification sites at PhosphoSitePlus

Other Protein References for ITPRIPL1 Gene

No data available for DME Specific Peptides for ITPRIPL1 Gene

Domains for ITPRIPL1 Gene

Protein Domains for ITPRIPL1 Gene

Suggested Antigen Peptide Sequences for ITPRIPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6GPH6

UniProtKB/Swiss-Prot:

IPIL1_HUMAN :
  • Q6GPH6
Family:
  • Belongs to the ITPRIP family.
genes like me logo Genes that share domains with ITPRIPL1: view

No data available for Gene Families for ITPRIPL1 Gene

Function for ITPRIPL1 Gene

Gene Ontology (GO) - Molecular Function for ITPRIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ITPRIPL1: view

Phenotypes for ITPRIPL1 Gene

GenomeRNAi human phenotypes for ITPRIPL1:
genes like me logo Genes that share phenotypes with ITPRIPL1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPRIPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITPRIPL1 Gene

Localization for ITPRIPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPRIPL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITPRIPL1 Gene COMPARTMENTS Subcellular localization image for ITPRIPL1 gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITPRIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITPRIPL1: view

Pathways for ITPRIPL1 Gene

SuperPathways for ITPRIPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ITPRIPL1 Gene

None

No data available for Pathways by source for ITPRIPL1 Gene

Transcripts for ITPRIPL1 Gene

Unigene Clusters for ITPRIPL1 Gene

Inositol 1,4,5-trisphosphate receptor interacting protein-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPRIPL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITPRIPL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIPL1 Gene

No ASD Table

Relevant External Links for ITPRIPL1 Gene

GeneLoc Exon Structure for
ITPRIPL1
ECgene alternative splicing isoforms for
ITPRIPL1

Expression for ITPRIPL1 Gene

mRNA expression in normal human tissues for ITPRIPL1 Gene

mRNA differential expression in normal tissues according to GTEx for ITPRIPL1 Gene

This gene is overexpressed in Testis (16.0).

SOURCE GeneReport for Unigene cluster for ITPRIPL1 Gene Hs.65009

genes like me logo Genes that share expressions with ITPRIPL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ITPRIPL1 Gene

Orthologs for ITPRIPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITPRIPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPRIPL1 35
  • 99.64 (n)
  • 99.28 (a)
ITPRIPL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITPRIPL1 35
  • 88.03 (n)
  • 90.66 (a)
ITPRIPL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITPRIPL1 35
  • 91 (n)
  • 93.98 (a)
ITPRIPL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpripl1 35
  • 86.67 (n)
  • 88.07 (a)
Itpripl1 16
Itpripl1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itpripl1 35
  • 86.3 (n)
  • 88.44 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 22 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ITPRIPL1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-80c12.4 36
  • 20 (a)
ManyToMany
Species with no ortholog for ITPRIPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITPRIPL1 Gene

ENSEMBL:
Gene Tree for ITPRIPL1 (if available)
TreeFam:
Gene Tree for ITPRIPL1 (if available)

Paralogs for ITPRIPL1 Gene

Paralogs for ITPRIPL1 Gene

Selected SIMAP similar genes for ITPRIPL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITPRIPL1: view

Variants for ITPRIPL1 Gene

Sequence variations from dbSNP and Humsavar for ITPRIPL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs772174 -- 96,325,754(+) CTCCT(A/G)GAGAG utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs1048675 -- 96,328,146(+) ATCCC(A/C/G)ATCCC reference, synonymous-codon
rs2279105 - 96,328,019(+) CCTCA(C/T)GGACT reference, missense
rs7588478 -- 96,323,762(+) gtttc(A/G)aatag upstream-variant-2KB
rs17853311 - 96,327,469(+) TCCTA(A/G)GGGAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ITPRIPL1 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv874679 CNV Gain 21882294
nsv508155 CNV Loss 20534489

Relevant External Links for ITPRIPL1 Gene

HapMap Linkage Disequilibrium report
ITPRIPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPRIPL1 Gene

Disorders for ITPRIPL1 Gene

No disorders were found for ITPRIPL1 Gene.

No data available for UniProtKB/Swiss-Prot for ITPRIPL1 Gene

Publications for ITPRIPL1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ITPRIPL1 Gene

Sources for ITPRIPL1 Gene

Back to Top

Content