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ITPRIP Gene

protein-coding   GIFtS: 51
GCID: GC10M106062

Inositol 1,4,5-Trisphosphate Receptor Interacting Protein

(Previous names: KIAA1754, inositol 1,4,5-triphosphate receptor interacting...)
(Previous symbol: KIAA1754)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol 1,4,5-Trisphosphate Receptor Interacting Protein1 2     bA127L20.22
KIAA17541 2 3     Inositol 1,4,5-Triphosphate Receptor-Interacting Protein2
DANGER2 3     Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein2
Inositol 1,4,5-Triphosphate Receptor Interacting Protein1     Protein DANGER3
bA127L202     

External Ids:    HGNC: 293701   Entrez Gene: 854502   Ensembl: ENSG000001488417   UniProtKB: Q8IWB13   

Export aliases for ITPRIP gene to outside databases

Previous GC identifer: GC10M099703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITPRIP Gene:
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The
encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for ITPRIP Gene:
ITPRIP (inositol 1,4,5-trisphosphate receptor interacting protein) is a protein-coding gene. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is ITPRIPL2.

UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1
Function: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITPRIP gene promoter:
         Meis-1b   POU2F1   POU2F1b   POU2F1a   FOXO4   FOXO1a   POU2F1c   NF-kappaB1   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITPRIP promoter sequence
   Search Chromatin IP Primers for ITPRIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITPRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.1

ITPRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITPRIP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M106062:  view genomic region     (about GC identifiers)

Start:
106,071,894 bp from pter      End:
106,098,162 bp from pter
Size:
26,269 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1 (See protein sequence)
Recommended Name: Inositol 1,4,5-trisphosphate receptor-interacting protein precursor  
Size: 547 amino acids; 62060 Da
Subunit: Interacts with ITPR
Sequence caution: Sequence=BAB21845.1; Type=Erroneous initiation;
Secondary accessions: D3DRA5 Q5JU17 Q96MS8 Q9C0A9

Explore the universe of human proteins at neXtProt for ITPRIP: NX_Q8IWB1

Explore proteomics data for ITPRIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys66, Lys244, Lys261, Lys515
  • Glycosylation2 at Asn27, Asn80
  • Modification sites at PhosphoSitePlus

  • See ITPRIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258941.1  NP_001258942.1  NP_203755.1  

    ENSEMBL proteins: 
     ENSP00000337178   ENSP00000350915   ENSP00000414141   ENSP00000278071  

    ITPRIP Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ITPRIP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITPRIP
    GenScript Custom Purified and Recombinant Proteins Services for ITPRIP
    Novus Biologicals ITPRIP Protein
    Novus Biologicals ITPRIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ITPRIP

     
    Search eBioscience for Proteins for ITPRIP 

     
    antibodies-online proteins for ITPRIP (2 products) 

     
    antibodies-online peptides for ITPRIP

    ITPRIP Antibody Products:

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    ThermoFisher Antibody for ITPRIP
    LSBio Antibodies in human, mouse, rat for ITPRIP
    antibodies-online antibodies for ITPRIP (3 products) 

    ITPRIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ITPRIP
    Cloud-Clone Corp. CLIAs for ITPRIP
    Search eBioscience for ELISAs for ITPRIP 
    antibodies-online kits for ITPRIP (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024797 IP3R-int
     IPR026250 INOS145TPRIP
     IPR024810 Mab-21_dom

    Graphical View of Domain Structure for InterPro Entry Q8IWB1

    ProtoNet protein and cluster: Q8IWB1

    UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1
    Similarity: Belongs to the ITPRIP family


    Find genes that share domains with ITPRIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPRI_HUMAN, Q8IWB1
    Function: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ITPRIP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITPRIP:
     Decreased viability of wild-ty  High actin ratio cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itprip):
     cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with ITPRIP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itpriptm1.1Snyd for ITPRIP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITPRIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITPRIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITPRIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITPRIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITPRIP:
    hsa-mir-93-3p (MIRT038902), hsa-mir-124-3p (MIRT022688), hsa-mir-30a-5p (MIRT028624), hsa-mir-335-5p (MIRT019219)

    Block miRNA regulation of human, mouse, rat ITPRIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITPRIP (see all 19):
    hsa-miR-3910 hsa-miR-485-5p hsa-miR-4254 hsa-miR-639 hsa-miR-1205 hsa-miR-1297 hsa-miR-515-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidITPRIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITPRIP
    Predesigned siRNA for gene silencing in human, mouse, rat ITPRIP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITPRIP

    Clone
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    OriGene clones in human, mouse for ITPRIP (see all 6)
    OriGene ORF clones in mouse, rat for ITPRIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITPRIP (NM_033397)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITPRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITPRIP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPRI_HUMAN, Q8IWB1: Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with ITPRIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITPRIP
    Interactions:

        Search GeneGlobe Interaction Network for ITPRIP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ITPRIP (ENSP000002780714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITPR1ENSP000004059344STRING: ENSP00000405934
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity ----
    GO:0043066negative regulation of apoptotic process ----
    GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA--

    Find genes that share ontologies with ITPRIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITPRIP (IPRI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITPRIP gene (3 alternative transcripts): 
    NM_001272012.1  NM_001272013.1  NM_033397.3  

    Unigene Cluster for ITPRIP:

    Inositol 1,4,5-trisphosphate receptor interacting protein
    Hs.523252  [show with all ESTs]
    Unigene Representative Sequence: NM_033397
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337478(uc001kyg.3) ENST00000358187(uc001kye.3) ENST00000458723
    ENST00000278071(uc001kyf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITPRIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITPRIP (see all 19):
    hsa-miR-3910 hsa-miR-485-5p hsa-miR-4254 hsa-miR-639 hsa-miR-1205 hsa-miR-1297 hsa-miR-515-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidITPRIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITPRIP
    Predesigned siRNA for gene silencing in human, mouse, rat ITPRIP
    Clone
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    OriGene clones in human, mouse for ITPRIP (see all 6)
    OriGene ORF clones in mouse, rat for ITPRIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITPRIP (NM_033397)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITPRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITPRIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITPRIP
      QuantiTect SYBR Green Assays in human, mouse, rat ITPRIP
      QuantiFast Probe-based Assays in human, mouse, rat ITPRIP

    Additional mRNA sequence: 

    AB051541.1 AK055608.1 AK056526.1 AK094802.1 AK129877.1 AY189283.1 AY358776.1 BC040536.1 
    BC070108.1 

    6 DOTS entries:

    DT.100771557  DT.100771556  DT.413738  DT.435096  DT.100771559  DT.99968479 

    Selected AceView cDNA sequences (see all 122):

    BI062548 CD365193 CA446184 BQ009278 BF885441 AA479528 BC070108 BC040536 
    AA631174 BU677876 NM_033397 AA682661 BM695216 BI053557 CO246643 BM998061 
    BM710925 AA479525 AI910786 BF000686 CD517856 AB051541 CA391089 BM693107 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                    -                     
    SP2:                                          
    SP3:        -     -     -                     


    ECgene alternative splicing isoforms for ITPRIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITPRIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCTTATT
    ITPRIP Expression
    About this image


    ITPRIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ITPRIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITPRIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523252

    UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1
    Tissue specificity: Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level)

        Custom PCR Arrays for ITPRIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITPRIP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itprip1 , 5 inositol 1,4,5-triphosphate receptor interacting protein1, 5 81.68(n)1
    78.68(a)1
      19 (40.49 cM)5
    4148011  NM_001001738.21  NP_001001738.21 
     478945985 
    chicken
    (Gallus gallus)
    Aves ITPRIP1 inositol 1,4,5-trisphosphate receptor interacting protein 65.56(n)
    59.81(a)
      428979  XM_004942269.1  XP_004942326.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITPRIP6
    inositol 1,4,5-trisphosphate receptor interacting ...
    55(a)
    1 ↔ 1
    3(41619064-41620713)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itprip1 inositol 1,4,5-trisphosphate receptor interacting protein 59.8(n)
    56.37(a)
      100486707  XM_002942919.2  XP_002942965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itprip1 inositol 1,4,5-triphosphate receptor interacting protein 54.95(n)
    49.22(a)
      550570  NM_001017872.1  NP_001017872.1 


    ENSEMBL Gene Tree for ITPRIP (if available)
    TreeFam Gene Tree for ITPRIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITPRIP gene
    ITPRIPL22  ITPRIPL12  
    1 SIMAP similar gene for ITPRIP using alignment to 1 protein entry:     IPRI_HUMAN:
    ITPRIPL1

    Find genes that share paralogs with ITPRIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITPRIP (see all 571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs765138251,2
    C--106431372(+) CAGACA/GGTGAG 3 -- ds50010--------
    rs575342331,2
    C--106431409(+) TATAT-/A/ATA 
    TATA
    /TTT
    TATAT
    6 -- ds5001 cds11NA 2
    rs2018530391,2
    C--106431409(+) TATAT-/AT    
       ATATA
    TTTTT
    3 -- ds50010--------
    rs1999143021,2
    --106431413(+) TATAT-/ATATTTTT 3 -- ds50010--------
    rs74779191,2
    A--106431415(+) tatatA/Tttttt 3 -- ds50011Minor allele frequency- T:0.00NA 2
    rs611481811,2
    C--106431415(+) TATAT-/ATTTTT 3 -- ds50010--------
    rs79042021,2
    C,A--106431417(+) tatatA/Tttttt 3 -- ds50010--------
    rs1500615871,2
    C--106431544(+) CCTCCG/TGAGTA 3 -- ds50010--------
    rs1874655201,2
    --106431701(+) GGTGTA/GAGCTA 3 -- ds50010--------
    rs1928491781,2
    --106431859(+) ACACAG/TAAAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ITPRIP (106071894 - 106098162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ITPRIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1968684CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITPRIP
    DNA2.0 Custom Variant and Variant Library Synthesis for ITPRIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ITPRIP           About GenesLikeMe

    Genetic Association Database (GAD): ITPRIP
    Human Genome Epidemiology (HuGE) Navigator: ITPRIP (2 documents)

    Export disorders for ITPRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITPRIP gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ITPRIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate- receptor activity. (PubMed id 16990268)1, 2, 3 van Rossum D.B.... Snyder S.H. (J. Biol. Chem. 2006)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. PHYRN: a robust method for phylogenetic analysis of highly divergent sequences. (PubMed id 22514627)1 Bhardwaj G....van Rossum D.B. (PLoS ONE 2012)
    7. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85450 HGNC: 29370 AceView: KIAA1754 Ensembl:ENSG00000148841 euGenes: HUgn85450
    ECgene: ITPRIP H-InvDB: ITPRIP

    (According to HUGE)
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    HUGE: KIAA1754

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITPRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ITPRIP gene:
    Search GeneIP for patents involving ITPRIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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