ITPRIP Gene
protein-coding GIFtS: 47
GCID: GC10M106062
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inositol 1,4,5-trisphosphate receptor interacting protein(Previous names: KIAA1754, inositol 1,4,5-triphosphate receptor interacting...)
(Previous symbol: KIAA1754)
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Aliases
for ITPRIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inositol 1,4,5-Trisphosphate Receptor Interacting Protein1 2 | | BA127L201 | | DANGER1 2 3 | | Inositol 1,4,5-Triphosphate Receptor-Interacting Protein2 | | KIAA17541 2 3 | | Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein2 | | BA127L20.21 | | Protein DANGER3 | | Inositol 1,4,5-Triphosphate Receptor Interacting Protein1 | | |
Export aliases for ITPRIP gene to outside databasesPrevious GC identifer: GC10M099703 |
Summaries
for ITPRIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ITPRIP:
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). Theencoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1Function: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release
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Genomic Views
for ITPRIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ITPRIP gene promoter:
Meis-1b POU2F1 POU2F1b POU2F1a FOXO4 FOXO1a POU2F1c NF-kappaB1 Meis-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ITPRIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPRIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25.1 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.1ITPRIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M106062: view genomic region
(about GC identifiers)
Start:
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106,071,894 bp from pter |
End:
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106,098,162 bp from pter |
Size:
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26,269 bases |
Orientation:
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minus strand |
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Proteins
for ITPRIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1 (See
protein sequence)Recommended Name: Inositol 1,4,5-trisphosphate receptor-interacting protein precursor Size: 547 amino acids; 62060 Da
Subunit: Interacts with ITPR
Subcellular location: Cell membrane
Sequence caution: Sequence=BAB21845.1; Type=Erroneous initiation;
Secondary accessions: D3DRA5 Q5JU17 Q96MS8 Q9C0A9Explore the universe of human proteins at neXtProt for ITPRIP: NX_Q8IWB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWB1
ITPRIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001258941.1 NP_001258942.1 NP_203755.1
ENSEMBL proteins: ENSP00000337178 ENSP00000350915 ENSP00000414141 ENSP00000278071
Human Recombinant Protein Products for ITPRIP:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
ITPRIP for ontologies About GeneDecksing
ITPRIP Antibody Products:
Assay Products for ITPRIP: |
Protein
Domains /
Families
for ITPRIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ITPRIP for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWB1ProtoNet protein and cluster: Q8IWB1 UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1Similarity: Belongs to the ITPRIP family |
Function
for ITPRIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IPRI_HUMAN, Q8IWB1Function: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) releasePhenotypes:
2 GenomeRNAi human phenotypes for ITPRIP:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Itprip):
ITPRIP for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Itpriptm1.1Snyd for ITPRIP
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ITPRIP (NM_033397) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITPRIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIP |
|
Pathways & Interactions
for ITPRIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITPRIP
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ITPRIP (ENSP000002780714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ITPRIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ITPRIP
Search CenterWatch for drugs/clinical trials and news about ITPRIP / IPRI
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Transcripts
for ITPRIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ITPRIP gene (3 alternative transcripts): NM_001272012.1 NM_001272013.1 NM_033397.3 Unigene Cluster for ITPRIP: Inositol 1,4,5-trisphosphate receptor interacting protein Hs.523252 [show with all ESTs]Unigene Representative Sequence: NM_0333975 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337478(uc001kyg.3) ENST00000472915 ENST00000358187(uc001kye.3)
ENST00000458723 ENST00000278071(uc001kyf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ITPRIP (NM_033397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITPRIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIP |
Additional cDNA sequence: AB051541.1 AK055608.1 AK056526.1 AK094802.1 AK129877.1 AY189283.1 AY358776.1 BC040536.1 BC070108.1 5 DOTS entries: DT.100771557 DT.100771556 DT.413738 DT.100771559 DT.99968479 24/122 AceView cDNA sequences (see all 122): CO245386 CD517856 AA682661 CD365193 CA446184 BQ009278 AB051541 AA631174 CO246643 BQ216709 BM695216 CA391089 BQ002177 NM_033397 BM998061 BI062548 AI910786 BC070108 BM693107 AW339700 AA479528 BM710925 BF885441 BF000686
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIP About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
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| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for ITPRIP
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Expression
for ITPRIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ITPRIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCTTATT
About this image
See ITPRIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITPRIP
SOURCE GeneReport for Unigene cluster: Hs.523252
UniProtKB/Swiss-Prot: IPRI_HUMAN, Q8IWB1Tissue specificity: Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level)
SABiosciences Custom PCR Arrays for ITPRIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITPRIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITPRIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPRIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPRIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIP |
Orthologs
for ITPRIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for ITPRIP gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for ITPRIP (if available)
TreeFam Gene Tree for ITPRIP (if available) |
Paralogs
for ITPRIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ITPRIP gene
- ITPRIPL22 ITPRIPL12
1 SIMAP similar gene for ITPRIP using alignment to 1 protein entry: IPRI_HUMAN:ITPRIPL1
ITPRIP for paralogs About GeneDecksing
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Genomic Variants
for ITPRIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ITPRIP (106071894 - 106098162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ITPRIP
1 Indel: 44660 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITPRIP |
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Disorders
/ Diseases
for ITPRIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ITPRIP for disorders About GeneDecksing
5  diseases for ITPRIP: About MalaCardswest nile encephalitis specific phobia phobia encephalitis
alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: ITPRIP (2 documents)
Export disorders for ITPRIP gene to outside databases
|
Publications
for ITPRIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ITPRIP gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ITPRIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate- receptor activity. (PubMed id 16990268)1, 2, 3 van Rossum D.B.... Snyder S.H. (2006)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- PHYRN: a robust method for phylogenetic analysis of hi ghly divergent sequences. (PubMed id 22514627)1 Bhardwaj G....van Rossum D.B. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for ITPRIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ITPRIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ITPRIP gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ITPRIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ITPRIP | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ITPRIP gene:
Search GeneIP for patents involving ITPRIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ITPRIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ITPRIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITPRIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITPRIP | | | OriGene Protein Over-expression Lysate for ITPRIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ITPRIP | | OriGene 3'-UTR Clone for ITPRIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITPRIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITPRIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITPRIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPRIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITPRIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPRIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPRIP |
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| | | | Search Tocris compounds for ITPRIP |
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 | | | ITPRIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPRIP |
|  |  |  |  | | | | ThermoFisher Antibody for ITPRIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPRIP |
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