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Aliases for ITPRIP Gene

Aliases for ITPRIP Gene

  • Inositol 1,4,5-Trisphosphate Receptor Interacting Protein 2 3 5
  • KIAA1754 2 3 4
  • DANGER 3 4
  • Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein 3
  • Inositol 1,4,5-Triphosphate Receptor Interacting Protein 2
  • Inositol 1,4,5-Triphosphate Receptor-Interacting Protein 3
  • Protein DANGER 4
  • BA127L20.2 3
  • BA127L20 3

External Ids for ITPRIP Gene

Previous HGNC Symbols for ITPRIP Gene

  • KIAA1754

Previous GeneCards Identifiers for ITPRIP Gene

  • GC10M106062
  • GC10M099703

Summaries for ITPRIP Gene

Entrez Gene Summary for ITPRIP Gene

  • This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for ITPRIP Gene

ITPRIP (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein) is a Protein Coding gene. An important paralog of this gene is ITPRIPL1.

UniProtKB/Swiss-Prot for ITPRIP Gene

  • Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPRIP Gene

Genomics for ITPRIP Gene

Regulatory Elements for ITPRIP Gene

Enhancers for ITPRIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ITPRIP on UCSC Golden Path with GeneCards custom track

Promoters for ITPRIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ITPRIP Gene

104,309,696 bp from pter
104,338,493 bp from pter
28,798 bases
Minus strand

Genomic View for ITPRIP Gene

Genes around ITPRIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPRIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPRIP Gene

Proteins for ITPRIP Gene

  • Protein details for ITPRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor-interacting protein
    Protein Accession:
    Secondary Accessions:
    • D3DRA5
    • Q5JU17
    • Q96MS8
    • Q9C0A9

    Protein attributes for ITPRIP Gene

    547 amino acids
    Molecular mass:
    62060 Da
    Quaternary structure:
    • Interacts with ITPR.
    • Sequence=BAB21845.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ITPRIP Gene

Post-translational modifications for ITPRIP Gene

  • Ubiquitination at Lys 66, Lys 244, Lys 261, and Lys 515
  • Glycosylation at Asn 27 and Asn 80
  • Modification sites at PhosphoSitePlus

Other Protein References for ITPRIP Gene

No data available for DME Specific Peptides for ITPRIP Gene

Domains & Families for ITPRIP Gene

Protein Domains for ITPRIP Gene


Suggested Antigen Peptide Sequences for ITPRIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ITPRIP family.
  • Belongs to the ITPRIP family.
genes like me logo Genes that share domains with ITPRIP: view

No data available for Gene Families for ITPRIP Gene

Function for ITPRIP Gene

Molecular function for ITPRIP Gene

UniProtKB/Swiss-Prot Function:
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
genes like me logo Genes that share phenotypes with ITPRIP: view

Animal Models for ITPRIP Gene

MGI Knock Outs for ITPRIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITPRIP

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPRIP Gene

Localization for ITPRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPRIP Gene

Cell membrane.

Subcellular locations from

Jensen Localization Image for ITPRIP Gene COMPARTMENTS Subcellular localization image for ITPRIP gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ITPRIP: view

Pathways & Interactions for ITPRIP Gene

SuperPathways for ITPRIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ITPRIP Gene


No data available for Pathways by source and SIGNOR curated interactions for ITPRIP Gene

Drugs & Compounds for ITPRIP Gene

No Compound Related Data Available

Transcripts for ITPRIP Gene

Unigene Clusters for ITPRIP Gene

Inositol 1,4,5-trisphosphate receptor interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: - - -

Relevant External Links for ITPRIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITPRIP Gene

mRNA expression in normal human tissues for ITPRIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITPRIP Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for ITPRIP Gene

This gene is overexpressed in Bone (22.8), Breast (11.2), Peripheral blood mononuclear cells (9.9), and Adrenal (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITPRIP Gene

Protein tissue co-expression partners for ITPRIP Gene

NURSA nuclear receptor signaling pathways regulating expression of ITPRIP Gene:


SOURCE GeneReport for Unigene cluster for ITPRIP Gene:


mRNA Expression by UniProt/SwissProt for ITPRIP Gene:

Tissue specificity: Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level).
genes like me logo Genes that share expression patterns with ITPRIP: view

Primer Products

Orthologs for ITPRIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITPRIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITPRIP 34
  • 87.51 (n)
  • 87.02 (a)
  • 85 (a)
(Canis familiaris)
Mammalia ITPRIP 34
  • 87.34 (n)
  • 86.97 (a)
  • 86 (a)
(Mus musculus)
Mammalia Itprip 34
  • 81.68 (n)
  • 78.68 (a)
Itprip 16
Itprip 35
  • 77 (a)
(Pan troglodytes)
Mammalia ITPRIP 34
  • 99.63 (n)
  • 99.63 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100912218 34
  • 82.63 (n)
  • 81.28 (a)
(Monodelphis domestica)
Mammalia ITPRIP 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ITPRIP 35
  • 67 (a)
(Gallus gallus)
Aves ITPRIP 34
  • 65.56 (n)
  • 59.81 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia ITPRIP 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itprip 34
  • 59.8 (n)
  • 56.37 (a)
(Danio rerio)
Actinopterygii itprip 34
  • 54.95 (n)
  • 49.22 (a)
itprip 35
  • 45 (a)
Species where no ortholog for ITPRIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITPRIP Gene

Gene Tree for ITPRIP (if available)
Gene Tree for ITPRIP (if available)

Paralogs for ITPRIP Gene

Paralogs for ITPRIP Gene

(1) SIMAP similar genes for ITPRIP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITPRIP: view

Variants for ITPRIP Gene

Sequence variations from dbSNP and Humsavar for ITPRIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs276198 -- 104,319,698(-) ACTGA(A/G)CCCCA intron-variant
rs276199 -- 104,319,434(-) AAGGA(A/G)GAGAA intron-variant
rs276208 -- 104,312,697(+) CACCA(A/C/G/T)GAATT utr-variant-3-prime
rs276209 -- 104,312,769(+) GGGGA(C/G/T)GGGGG utr-variant-3-prime
rs276212 -- 104,331,429(-) CCGCT(A/G)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPRIP Gene

Variant ID Type Subtype PubMed ID
esv1968684 CNV deletion 18987734
nsv474104 CNV novel sequence insertion 20440878
nsv951841 CNV deletion 24416366

Variation tolerance for ITPRIP Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITPRIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPRIP Gene

Disorders for ITPRIP Gene

Relevant External Links for ITPRIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITPRIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPRIP Gene

Publications for ITPRIP Gene

  1. DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate- receptor activity. (PMID: 16990268) van Rossum D.B. … Snyder S.H. (J. Biol. Chem. 2006) 2 3 4 65
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for ITPRIP Gene

Sources for ITPRIP Gene

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