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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITPR2 Gene

protein-coding GIFtS: 61
GCID: GC12M026390

inositol 1,4,5-trisphosphate receptor, type 2

(Previous names: inositol 1,4,5-triphosphate receptor, type 2 )

Explore 15 diseases affiliated with
ITPR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inositol 1,4,5-Trisphosphate Receptor, Type 2¹ ²		Inositol 1,4,5-Trisphosphate Receptor Type 2²
IP3R2¹ ²		InsP3R2³
Inositol 1,4,5-Triphosphate Receptor, Type 2¹ ²		IP3 Receptor²
Type 2 Inositol 1,4,5-Trisphosphate Receptor² ³		InsP3R2³
Type 2 InsP3 Receptor² ³		IP3 Receptor Isoform 2³
IP3R 2² ³

External Ids:	HGNC: 6181¹	Entrez Gene: 3709²	Ensembl: ENSG00000123104⁷	OMIM: 600144⁵	UniProtKB: Q14571³

Export aliases for ITPR2 gene to outside databases

Previous GC identifers: GC12M026850 GC12M026502 GC12M026381 GC12M026377 GC12M026258

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITPR2_HUMAN, Q14571

Function: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular

calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)

summary for ITPR2:

Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by

cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum,

and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in

intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2

and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and

FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Gene Wiki entry for ITPR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITPR2 gene promoter:
LUN-1 CBF-C C/EBPalpha SRY CBF-A CBF-B FOXO4 CP1C CP1A CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITPR2 promoter sequence

Search SABiosciences Chromatin IP Primers for ITPR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11 Ensembl cytogenetic band: 12p11.23 HGNC cytogenetic band: 12p11.23

ITPR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITPR2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M026390: view genomic region (about GC identifiers)

Start:	26,488,285 bp from pter	End:	26,986,131 bp from pter
Size:	497,847 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITPR2_HUMAN, Q14571 (See protein sequence)

Recommended Name: Inositol 1,4,5-trisphosphate receptor type 2

Size: 2701 amino acids; 308064 Da

Subunit: Homotetramer (By similarity). Interacts with CABP1

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Miscellaneous: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct

calcium-binding protein which then inhibits the receptor

Secondary accessions: O94773

Alternative splicing: 2 isoforms: Q14571-1 Q14571-2

Explore the universe of human proteins at neXtProt for ITPR2: NX_Q14571

Post-translational modifications:

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14571

ITPR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002214.2

ENSEMBL proteins:

ENSP00000370744 ENSP00000408287 ENSP00000440548 ENSP00000242737

Reactome Protein details: Q14571
Human Recombinant Protein Products for ITPR2:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ITPR2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001950	plasma membrane enriched fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	IDA	10828023

ITPR2 for ontologies About GeneDecksing

ITPR2 Antibody Products:

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	Search ThermoFisher Antibodies for ITPR2

Assay Products for ITPR2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ITPR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITPR2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR014821 Ins145_P3_rcpt

IPR000699 Ca-rel_channel

IPR013662 RIH_assoc-dom

IPR005821 Ion_trans_dom

IPR000493 InsP3_rcpt-bd

Graphical View of Domain Structure for InterPro Entry Q14571

ProtoNet protein and cluster: Q14571

4 Blocks protein families:

IPB000493 Inositol 1,4,5-trisphosphate-binding protein receptor signature

IPB000699 Intracellular calcium-release channel

IPB003608 MIR domain

IPB013662 RyR and IP3R Homology associated

UniProtKB/Swiss-Prot: ITPR2_HUMAN, Q14571

Domain: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region

has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the

channel region

Similarity: Belongs to the InsP3 receptor family

Similarity: Contains 5 MIR domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ITPR2_HUMAN, Q14571

Function: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular

calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)

Genatlas biochemistry entry for ITPR2:

inositol 1,4,5-triphosphate receptor,type 2,coexpressed with RYR3 in neurons and smooth muscle cells forming

heterotetrameric channel with ITPR1 and ITPR3,involved in mobilization from the endoplastic reticulum,highly sensitive

to IP3,required for long lasting,regular Ca++ oscillations,transcriptionally regulated during myelopoiesis target of

EVI-1 and EVI1-VP16 fusion gene

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IEA	--
GO:0015085	calcium ion transmembrane transporter activity	TAS	8081734
GO:0015278	calcium-release channel activity	--	--
GO:0035091	phosphatidylinositol binding	IEA	--

ITPR2 for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Itpr2):

behavior/neurological	cardiovascular system	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	mortality/aging	no phenotypic analysis	normal

ITPR2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ITPR2: Itpr2^tm1Kmik Itpr2^tm1.1Chen

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITPR2

miRNA Products:		OriGene 3'-UTR Clone: ITPR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITPR2
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPR2 (see all 54):
		hsa-miR-4291 hsa-miR-106a hsa-miR-605 hsa-miR-488 hsa-miR-570 hsa-miR-93 hsa-miR-3613-3p hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: ITPR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITPR2 (see all 7) OriGene shRNA RFP: ITPR2 OriGene siRNA: ITPR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITPR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ITPR2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ITPR2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITPR2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITPR2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITPR2 (NM_002223)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/83 super-pathways (see all 83) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

Development_Endothelin-1/EDNRA transactivation of EGFR

Development_Endothelin-1/EDNRA transactivation of EGFR	1.00	Development_Endothelin-1/EDNRA signaling	0.41
Development Endothelin-1/EDNRA transactivation of EGFR	1.00	Cytoskeleton remodeling_FAK signaling	0.41
Development Endothelin-1/EDNRA signaling	0.41	Cytoskeleton remodeling FAK signaling	0.41

DAG and IP3 signaling

DAG and IP3 signaling	1.00	PLCG1 events in ERBB2 signaling	0.91
PLC-gamma1 signalling	0.94	Phospholipase C-mediated cascade	0.57
EGFR interacts with phospholipase C-gamma	0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

5/39 EMD Millipore Pathways for ITPR2 (see all 39)

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling FAK signaling
	Signal transduction IP3 signaling

5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITPR2 (see all 47)

	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	PI3K Signaling in B-Lymphocyte
	PACAP Signaling

5/41 GeneGo (Thomson Reuters) Pathways for ITPR2 (see all 41)

	Development FGF-family signaling
	Development Endothelin-1/EDNRA signaling
	Immune response CD28 signaling
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Development VEGF-family signaling

4 BioSystems Pathways for ITPR2

	Calcium Regulation in the Cardiac Cell
	Myometrial Relaxation and Contraction Pathways
	Alzheimers Disease
	B Cell Receptor Signaling Pathway

5/44 Reactome Pathways for ITPR2 (see all 44)

	Platelet homeostasis
	Signaling by EGFR in Cancer
	Elevation of cytosolic Ca2+ levels
	Downstream signal transduction
	Signal Transduction

5/14 Kegg Pathways (Kegg details for ITPR2) (see all 14):

	Calcium signaling pathway
	Phosphatidylinositol signaling system
	Oocyte meiosis
	Vascular smooth muscle contraction
	Gap junction

ITPR2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ITPR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for ITPR2 (Q14571^{2, 3} ENSP00000370744⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRPC4	Q9UBN4²^,³, ENSP00000369003⁴	MINT-14530 MINT-14529 I2D: score=3 STRING: ENSP00000369003
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=2 STRING: ENSP00000309591
BANK1	Q8NDB2³, ENSP00000320509⁴	I2D: score=1 STRING: ENSP00000320509
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
RAC1	P63000³	I2D: score=2

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	19120137
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006810	transport	TAS	8081734
GO:0006816	calcium ion transport	--	--
GO:0007165	signal transduction	TAS	--

ITPR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITPR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ITPR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
2-APB	IP3 receptor antagonist. Also TRP channel modulator	[524-95-8]

2 HMDB Compounds for ITPR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Inositol 1,4,5-trisphosphate	1D-myo-Inositol 1,4,5-trisphosphate (see all 4)	88269-39-0	--

3 Novoseek chemical compound relationships for ITPR2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol 1,4,5 trisphosphate	82.5	22	9560445 (1), 10810447 (1), 17332533 (1), 11842185 (1) (see all 14)
ryanodine	60.4	3	12407053 (1), 16847098 (1), 15710625 (1)
calcium	49.4	28	15710625 (3), 9166724 (3), 9560445 (1), 16525579 (1) (see all 11)

Search CenterWatch for drugs/clinical trials and news about ITPR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITPR2 gene:

NM_002223.2

Unigene Cluster for ITPR2:

Inositol 1,4,5-trisphosphate receptor, type 2

Hs.512235 [show with all ESTs]

Unigene Representative Sequence: NM_002223

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381340(uc001rhg.3 uc009zjg.1 uc001rhh.1 uc001rhi.1)

ENST00000451599 ENST00000538984 ENST00000540429 ENST00000543958 ENST00000545902

ENST00000540791 ENST00000545235 ENST00000242737 ENST00000536627

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITPR2
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPR2 (see all 54):
		hsa-miR-4291 hsa-miR-106a hsa-miR-605 hsa-miR-488 hsa-miR-570 hsa-miR-93 hsa-miR-3613-3p hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: ITPR2 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against ITPR2

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		GenScript: all cDNA clones in your preferred vector: ITPR2 (NM_002223)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITPR2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ITPR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITPR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITPR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPR2

Additional cDNA sequence:

AB012610.1 AK307686.1 AK307712.1 AK310504.1 AY429550.1 D26350.1

12 DOTS entries:

DT.121206042 DT.95266161 DT.85105496 DT.121206140 DT.91967173 DT.95266158 DT.121206111 DT.40198684

DT.75112376 DT.80101573 DT.95220632 DT.92030662

24/184 AceView cDNA sequences (see all 184):

BQ049409 BX103595 BX506844 AI040623 AA479246 AI264554 AA311523 BM851536

AI281517 BM834732 AI000717 AW044646 BM919068 AA705345 AA152014 AV725895

BM822179 BQ025344 T29911 CB156970 F03841 F07593 BE745875 CA308243

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITPR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAATCGA

About this image

ITPR2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITPR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITPR2

SOURCE GeneReport for Unigene cluster: Hs.512235

UniProtKB/Swiss-Prot: ITPR2_HUMAN, Q14571

Tissue specificity: Isoform Short is found in skeletal muscle and heart

SABiosciences Expression via Pathway-Focused PCR Arrays including ITPR2:

Hypertension in human mouse rat

Gap Junctions in human mouse rat

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITPR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITPR2
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITPR2 gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITPR2¹	inositol 1,4,5-trisphosphate receptor, type 2	83.15(n) 93.07(a)		418212 XM_001235612.2 XP_001235613.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	91(a) 5(a)	1 ↔ 1 possible ortholog	5(90786292-90999239) GL344770.1(13345-20285)
zebrafish (Danio rerio)	Actinopterygii	itpr2⁶ CABZ01099885.1⁶ (see all 3)	--	73(a) 4(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	18(15616686-15721490) Zv9_NA124(8681-20406)
fruit fly (Drosophila melanogaster)	Insecta	Itp-r83A³	molting cycle (sensu Insecta) inositol-1,4,5-triphosphate more	54(a)		--
worm (Caenorhabditis elegans)	Secernentea	itr-1³	inositol 1,4,5-triphosphate receptor	36(a)		IV(7675362-7696891) --

ENSEMBL Gene Tree for ITPR2 (if available)
TreeFam Gene Tree for ITPR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ITPR2 gene

RYR2² ITPR3² ITPR1² RYR1² RYR3²

2 SIMAP similar genes for ITPR2 using alignment to 4 protein entries: ITPR2_HUMAN (see all proteins):

ITPR1 ITPR3

ITPR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189758924^1,2		--	26487839(+)	`AGGAAC/TTGTGG`	1	--	ds500¹		0	--	--	--	--
rs181160506^1,2		--	26487873(+)	`ACAAAG/TAATTC`	1	--	ds500¹		0	--	--	--	--
rs76335470^1,2		--	26487914(+)	`CCATGC/TTGACT`	1	--	ds500¹		0	--	--	--	--
rs186151506^1,2		--	26488022(+)	`CCCACG/TGAGCT`	1	--	ds500¹		0	--	--	--	--
rs141294273^1,2		--	26488080(+)	`ATTGGA/GGAATT`	1	--	ds500¹		0	--	--	--	--
rs117367936^1,2		--	26488122(+)	`GTCCAT/ACTGGA`	1	--	ds500¹		1		EA	120
rs7302344^1,2	C,F,A,H	--	26488182(+)	`TTGCTA/GTGTAA`	1	--	ds500¹		18		NS EA NA WA	2340
rs188905745^1,2		--	26488310(+)	`TAACAC/TTCACT`	1	--	ut3¹		0	--	--	--	--
rs150232174^1,2		--	26488345(+)	`TATTGA/GAATCG`	1	--	ut3¹		0	--	--	--	--
rs117402201^1,2	C,F	--	26488376(+)	`NNNNCC/TTCTAC`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for ITPR2 (26488285 - 26738285 bp, first 250kb of ITPR2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for ITPR2
10 CNVs: 75983 101462 75984 86273 75981 86274 86275 75985 86277 75980
11 Indels: 39891 45027 24986 101461 42681 61216 101460 75982 39890 39889 86276

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ITPR2 for disorders           About GeneDecksing

OMIM gene information: 600144    OMIM disorders: --

15 diseases for ITPR2:    About MalaCards

amyotrophic lateral sclerosis lateral sclerosis myxoma sjogren's syndrome

hepatitis b liver cancer pharyngitis hepatitis

hypoxia pancreatitis neuronitis huntington's disease

glioblastoma breast cancer retinitis

Human Genome Epidemiology (HuGE) Navigator: ITPR2 (13 documents)

Export disorders for ITPR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITPR2 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with ITPR2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. (PubMed id 8081734)^{1, 2, 3} Yamamoto-Hino M....Mikoshiba K. (1994)
Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor. (PubMed id 9729462)^{1, 2} Futatsugi A.... Mikoshiba K. (1998)
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. (PubMed id 17827064)^{1, 9} van Es M.A....van den Berg L.H. (2007)
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. (PubMed id 18936250)^{1, 9} Tovey S.C....Taylor C.W. (2008)
A genome-wide association study identifies a novel sus ceptibility locus for renal cell carcinoma on 12p11.23. (PubMed id 22010048)¹ Wu X....Chanock S.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Distribution and functional role of inositol 1,4,5-tr isphosphate receptors in mouse sinoatrial node. (PubMed id 21852551)¹ Ju Y.K....Allen D.G. (2011)
No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort. (PubMed id 19464757)¹ FernA!ndez-Santiago R....Gasser T. (2011)
Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release. (PubMed id 21762810)¹ Ehrlich L.S....Carter C.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3709	HGNC: 6181	AceView: ITPR2	Ensembl:ENSG00000123104	euGenes: HUgn3709
ECgene: ITPR2	Kegg: 3709	H-InvDB: ITPR2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ITPR2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ITPR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITPR2 gene:
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ITPR2 Gene

inositol 1,4,5-trisphosphate receptor, type 2

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ITPR2 Gene

inositol 1,4,5-trisphosphate receptor, type 2

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