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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITPKB Gene

protein-coding   GIFtS: 62
GCID: GC01M226820

inositol-trisphosphate 3-kinase B

(Previous name: inositol 1,4,5-trisphosphate 3-kinase B )
 Explore 2 diseases affiliated with
ITPKB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITPKB    

Aliases
for ITPKB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inositol-Trisphosphate 3-Kinase B1 2     IP3K B2 3
Inositol 1,4,5-Trisphosphate 3-Kinase B1 2 3     EC 2.7.1.1273 8
IP3-3KB1 2     IP3K2
IP3KB1 2     IP3K-B2
InsP 3-Kinase B2 3     PIG372
IP3 3-Kinase B2 3     Proliferation-Inducing Protein 372

External Ids:    HGNC: 61791   Entrez Gene: 37072   Ensembl: ENSG000001437727   OMIM: 1475225   UniProtKB: P279873   

Export aliases for ITPKB gene to outside databases

Previous GC identifers: GC01M225348 GC01M222564 GC01M223204 GC01M223794 GC01M223126 GC01M224886 GC01M197336


Summaries
for ITPKB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITPKB:
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger
inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the
levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin
and protein phosphorylation mechanisms control its activity. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ITPKB


Genomic Views
for ITPKB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITPKB gene promoter:
         p53   Pax-5   NF-kappaB   C/EBPalpha   POU2F1   FOXC1   POU2F1a   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITPKB promoter sequence
   Search SABiosciences Chromatin IP Primers for ITPKB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.12

ITPKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITPKB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M226820:  view genomic region     (about GC identifiers)

Start:
 226,819,391 bp from pter      End:
 226,927,024 bp from pter
Size:
 107,634 bases      Orientation:
 minus strand

Proteins
for ITPKB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IP3KB_HUMAN, P27987 (See protein sequence)
Recommended Name: Inositol-trisphosphate 3-kinase B  
Size: 946 amino acids; 102376 Da
Sequence caution: Sequence=CAA40491.1; Type=Erroneous initiation;
Secondary accessions: Q5VWL9 Q5VWM0 Q96BZ2 Q96JS1 Q9UH47
Alternative splicing: 2 isoforms:  P27987-1   P27987-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITPKB: NX_P27987

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27987

    • 4/7 DME Specific Peptides for ITPKB (P27987) (see all 7)
     EGNREDGYL  IDFGKTTPLP  HEVIGSSLLF  VDPEAPTEEE 

    ITPKB Protein expression data from MOPED and PaxDb:    About this image 
    ITPKB Protein Expression
    REFSEQ proteins: NP_002212.3  
    ENSEMBL proteins: 
     ENSP00000272117   ENSP00000355748   ENSP00000411152  
    Reactome Protein details: P27987
    Human Recombinant Protein Products for ITPKB: 
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    Novus Biologicals ITPKB Proteins
    Novus Biologicals ITPKB Lysate
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    Uscn Proteins for ITPKB


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    Uscn ELISAs and CLIAs for ITPKB

    Protein Domains /
    Families
    for ITPKB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITPKB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry P27987

    ProtoNet protein and cluster: P27987

    1 Blocks protein family: IPB005522 Inositol polyphosphate kinase

    UniProtKB/Swiss-Prot: IP3KB_HUMAN, P27987
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    Function
    for ITPKB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IP3KB_HUMAN, P27987
    Catalytic activity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
    Enzyme regulation: IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A

         Genatlas biochemistry entry for ITPKB:
    inositol 1,4,5-triphosphate 3 kinase-B

         Enzyme Number (IUBMB): EC 2.7.1.1271 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--
         
    ITPKB for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itpkb):
     behavior/neurological  cellular  digestive/alimentary  growth/size  hematopoietic system 
     immune system  integument  mortality/aging 

    ITPKB for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Itpkbtm1Ssch for ITPKB
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITPKB 

    miRNA
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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPKB (see all 50):
    hsa-miR-106a hsa-miR-486-3p hsa-miR-301a hsa-miR-877* hsa-miR-4314 hsa-miR-124 hsa-miR-93 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: ITPKB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITPKB (see all 7)
    OriGene shRNA RFP: ITPKB
    OriGene siRNA: ITPKB
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ITPKB 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ITPKB 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITPKB (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPKB 

    Cell Line
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    Search LifeMap BioReagents cell lines for ITPKB
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPKB


    Pathways & Interactions
    for ITPKB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    		D-myo-inositol (1,3,4)-trisphosphate biosynthesis1.00
    		superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    		1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.76
    2Inositol phosphate metabolism
    		Inositol phosphate metabolism1.00
    		Phosphatidylinositol signaling system0.59
    		superpathway of inositol phosphate compounds0.59
    3Synthesis of IP3 and IP4 in the cytosol
    		Synthesis of IP3 and IP4 in the cytosol1.00
    		Inositol phosphate metabolism0.57
    4Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    5Calcium signaling pathway
    		Calcium signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for ITPKB 
        1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    superpathway of inositol phosphate compounds
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

    3        Reactome Pathways for ITPKB
        Metabolism
    Inositol phosphate metabolism
    Synthesis of IP3 and IP4 in the cytosol


    4         Kegg Pathways  (Kegg details for ITPKB):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Phosphatidylinositol signaling system


    ITPKB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITPKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for ITPKB (P279872, 3 ENSP000002721174) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    PSME3P612892, 3, ENSP000002933624MINT-68100 I2D: score=5 STRING: ENSP00000293362
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0007165signal transduction TAS1654894
    GO:0007166cell surface receptor signaling pathway IEA--
    GO:0030217T cell differentiation ----
    GO:0045059positive thymic T cell selection IEA--

    ITPKB for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITPKB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITPKB for compounds           About GeneDecksing

    EMD Millipore small molecules for ITPKB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITPKB

    5 HMDB Compounds for ITPKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    3 Novoseek chemical compound relationships for ITPKB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 84 1 19918943 (1)
    inositol 1,4,5 trisphosphate 81.3 15 9182721 (2), 16173920 (2), 9038348 (2), 8018850 (1) (see all 8)
    calcium 37.4 15 9182721 (3), 9038348 (3), 16500959 (1), 15101685 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ITPKB / IP3KB 

    Transcripts
    for ITPKB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITPKB gene: 
    NM_002221.3  

    Unigene Clusters for ITPKB:

    Inositol-trisphosphate 3-kinase B
    Hs.528087  [show with all ESTs], Hs.659396  [show with all ESTs]
    Unigene Representative Sequences: NM_002221, BX537724
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272117 ENST00000366784(uc001hqh.3) ENST00000429204(uc010pvo.2)


    miRNA
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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPKB (see all 50):
    hsa-miR-106a hsa-miR-486-3p hsa-miR-301a hsa-miR-877* hsa-miR-4314 hsa-miR-124 hsa-miR-93 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: ITPKB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITPKB (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: BX537724.1 

    8 DOTS entries:

    DT.315662  DT.412641  DT.75129418  DT.100769888  DT.40197440  DT.75199612  DT.92427379  DT.40125638 

    24/178 AceView cDNA sequences (see all 178):

    BU931592 BQ184263 CD651992 NM_002221 BU166486 BQ059797 AA746399 AI160409 
    CA396296 CD518163 BU684647 BU153869 CD673844 BU157153 BQ213989 BU848931 
    F02270 F04836 AI826761 BQ878513 CA396580 BM980409 BQ277624 BF340509 

    GeneLoc Exon Structure


    Expression
    for ITPKB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITPKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGTATAATG
    ITPKB Expression
    About this image

    ITPKB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ITPKB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITPKB

    SOURCE GeneReport for Unigene clusters: Hs.528087 Hs.659396
        SABiosciences Expression via Pathway-Focused PCR Array including ITPKB: 
              Lymphoma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPKB

    Orthologs
    for ITPKB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ITPKB gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ITPKB1 inositol-trisphosphate 3-kinase B 64.2(n)
    62.66(a)    		   416743  XM_415039.2  XP_415039.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ITPKB6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 1(251204167-251217754)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.138652 Xenopus laevis transcribed sequence with weak similarity more 76.24(n)    BJ064068.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii itpkb1 inositol-trisphosphate 3-kinase B 63.05(n)
    64.14(a)    		   563019  XM_686383.4  XP_691475.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta IP3K23 1D-myo-inositol-trisphosphate 3-kinase 61(a)
    (best of 2)    		   11E11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lfe-23 Expression: alimentary system, intestine,
    pharynx, more    		 43(a)   I(5027212-5040766)   --


    ENSEMBL Gene Tree for ITPKB (if available)
    TreeFam Gene Tree for ITPKB (if available) 

    Paralogs
    for ITPKB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITPKB gene
    ITPKC2  ITPKA2  
    3 SIMAP similar genes for ITPKB using alignment to 1 protein entry:     IP3KB_HUMAN:
    PIG37    ITPKA    ITPKC

    ITPKB for paralogs           About GeneDecksing



    Genomic Variants
    for ITPKB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1832 NCBI SNPs in ITPKB are shown (see all 1832)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796175981,2
    		--197360618(+) GGCACG/ACTTCC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs787005351,2
    		F--197360865(+) TTCCTT/CATCAG 1 -- ds50011Minor allele frequency- C:0.12WA 118
    rs46534601,2
    		F--197360890(+) TCTCCC/TGGAAG 1 -- ds5001 trp31Minor allele frequency- T:0.09EA 120
    rs595301901,2
    		C,F--197361068(+) ACATAC/TATACT 1 -- ds50013Minor allele frequency- T:0.10WA CSA 122
    rs760591941,2
    		F--197361574(+) CTTAGG/CCCCCC 1 -- nc-transcript-variant1Minor allele frequency- C:0.03WA 118
    rs799396781,2
    		--197361879(+) ATCACT/CTGGCT 1 -- int12Minor allele frequency- C:0.14CSA WA 120
    rs741397171,2
    		C--197362185(+) CAAAAG/CGTCAC 1 -- int12Minor allele frequency- C:0.16WA 120
    rs120773481,2
    		C,F,H--197362242(+) CCAACA/GGGATT 1 -- int128Minor allele frequency- G:0.22NS EA NA WA 2986
    rs11448321,2
    		H--197362648(+) TTTCCT/CTCACT 1 -- int14Minor allele frequency- C:0.00NS EA 414
    rs1133106991,2
    		--197362760(+) TGGGTA/GCAAGC 1 -- int12Minor allele frequency- G:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for ITPKB (226819391 - 226927024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ITPKB
         2 CNVs: 48256 48257

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    Disorders / Diseases
    for ITPKB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITPKB for disorders           About GeneDecksing

    OMIM gene information: 147522    OMIM disorders: --

    2 diseases for ITPKB:    About MalaCards
    hermaphroditism    alzheimer's disease

    Human Genome Epidemiology (HuGE) Navigator: ITPKB (4 documents)

    Export disorders for ITPKB gene to outside databases

    Publications
    for ITPKB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITPKB gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ITPKB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a new putative inositol 1,4,5- trisphosphate 3-kinase isoenzyme. (PubMed id 1654894)1, 2, 3 Takazawa K.... Erneux C. (1991)
    2. Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B. (PubMed id 11846419)1, 2, 9 Dewaste V.... Erneux C. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Localization of the genes for human inositol 1,4,5-tr isphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 an d 1q41-q43, respectively, by in situ hybridization. (PubMed id 1330886)1, 3 Erneux C....Mattei M.G. (1992)
    6. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. (PubMed id 16740130)1, 9 Nalaskowski M.M....Mayr G.W. (2006)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. A specific increase in inositol 1,4,5-trisphosphate 3- kinase B expression upon differentiation of human embryonic stem cells. (PubMed id 22446005)1 Hoofd C....Erneux C. (2012)
    9. Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cort ical actin filaments and at invaginations of the nuclear envelope. (PubMed id 21148483)1 Nalaskowski M.M....Mayr G.W. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for ITPKB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ITPKB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3707 HGNC: 6179 AceView: ITPKB Ensembl:ENSG00000143772 euGenes: HUgn3707
    ECgene: ITPKB Kegg: 3707 H-InvDB: ITPKB

    Other Databases showing ITPKB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITPKB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITPKB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITPKB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ITPKB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITPKB gene:
    Search GeneIP for patents involving ITPKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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