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Aliases for ITPKB Gene

Aliases for ITPKB Gene

  • Inositol-Trisphosphate 3-Kinase B 2 3
  • Inositol 1,4,5-Trisphosphate 3-Kinase B 2 3 4
  • InsP 3-Kinase B 3 4
  • IP3 3-Kinase B 3 4
  • EC 2.7.1.127 4 63
  • IP3K B 3 4
  • Proliferation-Inducing Protein 37 3
  • IP3-3KB 3
  • IP3K-B 3
  • IP3KB 3
  • PIG37 3
  • IP3K 3

External Ids for ITPKB Gene

Previous GeneCards Identifiers for ITPKB Gene

  • GC01M225348
  • GC01M222564
  • GC01M223204
  • GC01M223794
  • GC01M223126
  • GC01M224886
  • GC01M226820
  • GC01M197336

Summaries for ITPKB Gene

Entrez Gene Summary for ITPKB Gene

  • The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITPKB Gene

ITPKB (Inositol-Trisphosphate 3-Kinase B) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calmodulin binding and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is ITPKC.

Gene Wiki entry for ITPKB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKB Gene

Genomics for ITPKB Gene

Regulatory Elements for ITPKB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPKB Gene

Start:
226,631,690 bp from pter
End:
226,739,327 bp from pter
Size:
107,638 bases
Orientation:
Minus strand

Genomic View for ITPKB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKB Gene

Proteins for ITPKB Gene

  • Protein details for ITPKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27987-IP3KB_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase B
    Protein Accession:
    P27987
    Secondary Accessions:
    • Q5VWL9
    • Q5VWM0
    • Q96BZ2
    • Q96JS1
    • Q9UH47

    Protein attributes for ITPKB Gene

    Size:
    946 amino acids
    Molecular mass:
    102376 Da
    Quaternary structure:
    • Interacts with DMTN.
    SequenceCaution:
    • Sequence=CAA40491.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ITPKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITPKB Gene

Proteomics data for ITPKB Gene at MOPED

Selected DME Specific Peptides for ITPKB Gene

Post-translational modifications for ITPKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ITPKB Gene

Gene Families for ITPKB Gene

Protein Domains for ITPKB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ITPKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27987

UniProtKB/Swiss-Prot:

IP3KB_HUMAN :
  • P27987
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKB: view

Function for ITPKB Gene

Molecular function for ITPKB Gene

GENATLAS Biochemistry: inositol 1,4,5-triphosphate 3 kinase-B
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A

Enzyme Numbers (IUBMB) for ITPKB Gene

Gene Ontology (GO) - Molecular Function for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
genes like me logo Genes that share ontologies with ITPKB: view
genes like me logo Genes that share phenotypes with ITPKB: view

Animal Models for ITPKB Gene

MGI Knock Outs for ITPKB:

Animal Model Products

CRISPR Products

miRNA for ITPKB Gene

miRTarBase miRNAs that target ITPKB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPKB

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ITPKB Gene

Localization for ITPKB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITPKB Gene COMPARTMENTS Subcellular localization image for ITPKB gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ITPKB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKB Gene

Pathways for ITPKB Gene

genes like me logo Genes that share pathways with ITPKB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0007165 signal transduction TAS 1654894
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0030217 T cell differentiation --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with ITPKB: view

Compounds for ITPKB Gene

(5) HMDB Compounds for ITPKB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0

(3) Novoseek inferred chemical compound relationships for ITPKB Gene

Compound -log(P) Hits PubMed IDs
inositol 1,3,4,5-tetrakisphosphate 84 1
inositol 1,4,5 trisphosphate 81.3 11
calcium 37.4 10
genes like me logo Genes that share compounds with ITPKB: view

Transcripts for ITPKB Gene

mRNA/cDNA for ITPKB Gene

Unigene Clusters for ITPKB Gene

Inositol-trisphosphate 3-kinase B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPKB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKB Gene

No ASD Table

Relevant External Links for ITPKB Gene

GeneLoc Exon Structure for
ITPKB
ECgene alternative splicing isoforms for
ITPKB

Expression for ITPKB Gene

mRNA expression in normal human tissues for ITPKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPKB Gene

SOURCE GeneReport for Unigene cluster for ITPKB Gene Hs.528087

genes like me logo Genes that share expressions with ITPKB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ITPKB Gene

Orthologs for ITPKB Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPKB 35
  • 99.12 (n)
  • 98.52 (a)
ITPKB 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITPKB 35
  • 85 (n)
  • 80.56 (a)
ITPKB 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITPKB 35
  • 82.86 (n)
  • 78.74 (a)
ITPKB 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpkb 35
  • 81.67 (n)
  • 77.87 (a)
Itpkb 16
Itpkb 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITPKB 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITPKB 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itpkb 35
  • 80.74 (n)
  • 77.81 (a)
chicken
(Gallus gallus)
Aves ITPKB 35
  • 78.15 (n)
  • 79.72 (a)
ITPKB 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITPKB 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13865 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itpkb 35
  • 64.46 (n)
  • 67.14 (a)
zebrafish
(Danio rerio)
Actinopterygii itpkb 35
  • 66.67 (n)
  • 69.69 (a)
itpkb 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta IP3K2 35
  • 62.73 (n)
  • 57.45 (a)
IP3K2 36
  • 31 (a)
OneToMany
IP3K1 37
  • 37 (a)
IP3K2 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea lfe-2 36
  • 27 (a)
OneToMany
lfe-2 37
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3402 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ITPKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKB Gene

ENSEMBL:
Gene Tree for ITPKB (if available)
TreeFam:
Gene Tree for ITPKB (if available)

Paralogs for ITPKB Gene

Paralogs for ITPKB Gene

Selected SIMAP similar genes for ITPKB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITPKB: view

Variants for ITPKB Gene

Sequence variations from dbSNP and Humsavar for ITPKB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs696334 -- 226,692,699(-) TAAGC(A/T)GAGTG intron-variant
rs697847 -- 226,677,257(+) ACAGA(A/G)CTGGG intron-variant
rs697848 -- 226,692,562(-) CTGTG(C/G)CAGTG intron-variant
rs697849 -- 226,694,130(-) acaca(C/T)gtata intron-variant
rs697850 -- 226,695,585(+) TGCCC(A/G)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPKB Gene

Variant ID Type Subtype PubMed ID
nsv470779 CNV Loss 18288195
nsv873234 CNV Loss 21882294
nsv522446 CNV Loss 19592680
nsv4755 CNV Insertion 18451855
nsv873235 CNV Loss 21882294
esv992736 CNV Deletion 20482838
nsv516277 CNV Loss 19592680
nsv523759 CNV Loss 19592680

Relevant External Links for ITPKB Gene

HapMap Linkage Disequilibrium report
ITPKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKB Gene

Disorders for ITPKB Gene

Relevant External Links for ITPKB

Genetic Association Database (GAD)
ITPKB
Human Genome Epidemiology (HuGE) Navigator
ITPKB
genes like me logo Genes that share disorders with ITPKB: view

No data available for UniProtKB/Swiss-Prot for ITPKB Gene

Publications for ITPKB Gene

  1. Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B. (PMID: 11846419) Dewaste V. … Erneux C. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  2. Molecular cloning and expression of a new putative inositol 1,4,5- trisphosphate 3-kinase isoenzyme. (PMID: 1654894) Takazawa K. … Erneux C. (Biochem. J. 1991) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ITPKB Gene

Sources for ITPKB Gene

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