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Aliases for ITPKB Gene

Aliases for ITPKB Gene

  • Inositol-Trisphosphate 3-Kinase B 2 3 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase B 2 3 4
  • InsP 3-Kinase B 3 4
  • IP3 3-Kinase B 3 4
  • EC 2.7.1.127 4 63
  • IP3K B 3 4
  • Proliferation-Inducing Protein 37 3
  • IP3-3KB 3
  • IP3K-B 3
  • IP3KB 3
  • PIG37 3
  • IP3K 3

External Ids for ITPKB Gene

Previous GeneCards Identifiers for ITPKB Gene

  • GC01M225348
  • GC01M222564
  • GC01M223204
  • GC01M223794
  • GC01M223126
  • GC01M224886
  • GC01M226820
  • GC01M197336

Summaries for ITPKB Gene

Entrez Gene Summary for ITPKB Gene

  • The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITPKB Gene

ITPKB (Inositol-Trisphosphate 3-Kinase B) is a Protein Coding gene. Among its related pathways are Metabolism and Calcium signaling pathway. GO annotations related to this gene include calmodulin binding and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is ITPKC.

Gene Wiki entry for ITPKB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKB Gene

Genomics for ITPKB Gene

Regulatory Elements for ITPKB Gene

Promoters for ITPKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITPKB on UCSC Golden Path with GeneCards custom track

Genomic Location for ITPKB Gene

Chromosome:
1
Start:
226,631,690 bp from pter
End:
226,739,327 bp from pter
Size:
107,638 bases
Orientation:
Minus strand

Genomic View for ITPKB Gene

Genes around ITPKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKB Gene

Proteins for ITPKB Gene

  • Protein details for ITPKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27987-IP3KB_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase B
    Protein Accession:
    P27987
    Secondary Accessions:
    • Q5VWL9
    • Q5VWM0
    • Q96BZ2
    • Q96JS1
    • Q9UH47

    Protein attributes for ITPKB Gene

    Size:
    946 amino acids
    Molecular mass:
    102376 Da
    Quaternary structure:
    • Interacts with DMTN.
    SequenceCaution:
    • Sequence=CAA40491.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ITPKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITPKB Gene

Proteomics data for ITPKB Gene at MOPED

Selected DME Specific Peptides for ITPKB Gene

Post-translational modifications for ITPKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ITPKB Gene

Gene Families for ITPKB Gene

Protein Domains for ITPKB Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P27987

UniProtKB/Swiss-Prot:

IP3KB_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKB: view

Function for ITPKB Gene

Molecular function for ITPKB Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-B
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.

Enzyme Numbers (IUBMB) for ITPKB Gene

genes like me logo Genes that share phenotypes with ITPKB: view

Animal Models for ITPKB Gene

MGI Knock Outs for ITPKB:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKB Gene

Localization for ITPKB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITPKB Gene COMPARTMENTS Subcellular localization image for ITPKB gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ITPKB Gene

Pathways & Interactions for ITPKB Gene

genes like me logo Genes that share pathways with ITPKB: view

Gene Ontology (GO) - Biological Process for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0032957 inositol trisphosphate metabolic process IDA 1654894
GO:0035726 common myeloid progenitor cell proliferation IEA --
genes like me logo Genes that share ontologies with ITPKB: view

No data available for SIGNOR curated interactions for ITPKB Gene

Drugs & Compounds for ITPKB Gene

(3) Drugs for ITPKB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0

(4) Additional Compounds for ITPKB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0
genes like me logo Genes that share compounds with ITPKB: view

Transcripts for ITPKB Gene

Unigene Clusters for ITPKB Gene

Inositol-trisphosphate 3-kinase B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKB Gene

No ASD Table

Relevant External Links for ITPKB Gene

GeneLoc Exon Structure for
ITPKB
ECgene alternative splicing isoforms for
ITPKB

Expression for ITPKB Gene

mRNA expression in normal human tissues for ITPKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITPKB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Bone marrow mesenchymal stem cell (9.2), and Spinal cord (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPKB Gene



SOURCE GeneReport for Unigene cluster for ITPKB Gene Hs.528087

genes like me logo Genes that share expression patterns with ITPKB: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ITPKB Gene

Orthologs for ITPKB Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITPKB 35
  • 85 (n)
  • 80.56 (a)
ITPKB 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITPKB 35
  • 82.86 (n)
  • 78.74 (a)
ITPKB 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpkb 35
  • 81.67 (n)
  • 77.87 (a)
Itpkb 16
Itpkb 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITPKB 35
  • 99.12 (n)
  • 98.52 (a)
ITPKB 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itpkb 35
  • 80.74 (n)
  • 77.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ITPKB 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITPKB 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITPKB 35
  • 78.15 (n)
  • 79.72 (a)
ITPKB 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITPKB 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itpkb 35
  • 64.46 (n)
  • 67.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13865 35
zebrafish
(Danio rerio)
Actinopterygii itpkb 35
  • 66.67 (n)
  • 69.69 (a)
itpkb 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta IP3K1 37
  • 37 (a)
IP3K2 37
  • 61 (a)
IP3K2 35
  • 62.73 (n)
  • 57.45 (a)
IP3K2 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lfe-2 37
  • 43 (a)
lfe-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3402 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ITPKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKB Gene

ENSEMBL:
Gene Tree for ITPKB (if available)
TreeFam:
Gene Tree for ITPKB (if available)

Paralogs for ITPKB Gene

Paralogs for ITPKB Gene

(3) SIMAP similar genes for ITPKB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITPKB: view

Variants for ITPKB Gene

Sequence variations from dbSNP and Humsavar for ITPKB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs708776 - 226,735,804(-) AGATC(A/C/T)GGACA reference, missense
rs6667260 - 226,736,237(+) CAGGG(A/C)ATCAG reference, missense
rs3754413 - 226,736,495(+) GAGGG(C/T)AAGAT reference, missense
rs697847 -- 226,677,257(+) ACAGA(A/G)CTGGG intron-variant
rs697852 -- 226,727,033(+) TGCTA(A/G)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPKB Gene

Variant ID Type Subtype PubMed ID
nsv470779 CNV Loss 18288195
nsv873234 CNV Loss 21882294
nsv522446 CNV Loss 19592680
nsv4755 CNV Insertion 18451855
nsv873235 CNV Loss 21882294
esv992736 CNV Deletion 20482838
nsv516277 CNV Loss 19592680
nsv523759 CNV Loss 19592680

Variation tolerance for ITPKB Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.42; 97.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITPKB Gene

HapMap Linkage Disequilibrium report
ITPKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKB Gene

Disorders for ITPKB Gene

Relevant External Links for ITPKB

Genetic Association Database (GAD)
ITPKB
Human Genome Epidemiology (HuGE) Navigator
ITPKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITPKB

No disorders were found for ITPKB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKB Gene

Publications for ITPKB Gene

  1. Molecular cloning and expression of a new putative inositol 1,4,5- trisphosphate 3-kinase isoenzyme. (PMID: 1654894) Takazawa K. … Erneux C. (Biochem. J. 1991) 2 3 4 67
  2. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. (PMID: 16740130) Nalaskowski M.M. … Mayr G.W. (Biol. Chem. 2006) 3 23
  3. Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B. (PMID: 11846419) Dewaste V. … Erneux C. (Biochem. Biophys. Res. Commun. 2002) 3 23
  4. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C. … Mattei M.G. (Genomics 1992) 2 3
  5. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. (PMID: 24401760) Stygelbout V. … Brion J.P. (Brain 2014) 3

Products for ITPKB Gene

Sources for ITPKB Gene

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