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Aliases for ITPKB Gene

Aliases for ITPKB Gene

  • Inositol-Trisphosphate 3-Kinase B 2 3 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase B 2 3 4
  • InsP 3-Kinase B 3 4
  • IP3 3-Kinase B 3 4
  • EC 2.7.1.127 4 58
  • IP3K B 3 4
  • Proliferation-Inducing Protein 37 3
  • IP3-3KB 3
  • IP3K-B 3
  • IP3KB 3
  • PIG37 3
  • IP3K 3

External Ids for ITPKB Gene

Previous GeneCards Identifiers for ITPKB Gene

  • GC01M225348
  • GC01M222564
  • GC01M223204
  • GC01M223794
  • GC01M223126
  • GC01M224886
  • GC01M226820
  • GC01M197336

Summaries for ITPKB Gene

Entrez Gene Summary for ITPKB Gene

  • The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITPKB Gene

ITPKB (Inositol-Trisphosphate 3-Kinase B) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway and Metabolism. GO annotations related to this gene include calmodulin binding and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is ITPKA.

Gene Wiki entry for ITPKB Gene

Additional gene information for ITPKB Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKB Gene

Genomics for ITPKB Gene

Regulatory Elements for ITPKB Gene

Enhancers for ITPKB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H226686 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.5 +49.3 49340 7 CTCF MAZ JUN ZSCAN4 EBF1 ZIC2 NR2F2 JUND IKZF1 FOXP2 ITPKB ITPKB-AS1 STUM LOC105373117 ITPKB-IT1
GH01H226651 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28 +79.4 79371 16 HDGF PKNOX1 SIN3A FEZF1 YBX1 ETS1 GLIS2 ZNF143 FOS ATF7 ZNF678 ITPKB ACBD3 CDC42BPA STUM PSEN2 ITPKB-AS1 GC01P226605
GH01H226671 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +61.3 61265 12 HDGF PKNOX1 ATF1 FEZF1 ZNF2 ZNF121 ATF7 RUNX3 SP3 GLIS1 ITPKB STUM ITPKB-IT1 LOC105373117
GH01H226708 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +27.7 27715 6 PKNOX1 FOXA2 ZNF133 FEZF1 GLI4 ZNF2 YY1 ZNF121 ZNF302 ZNF143 ZNF678 ACBD3 CDC42BPA ITPKB ITPKB-AS1 LINC01703 ENSG00000272562 LOC105373117 GC01M226732
GH01H226695 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +41.8 41817 3 PKNOX1 ESRRA MAX ZMYM3 EBF1 RFX5 CTBP1 GATA3 ZNF366 EED ITPKB H3F3A PSEN2 LOC105373117 ITPKB-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITPKB on UCSC Golden Path with GeneCards custom track

Promoters for ITPKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021143 927 2801 HDGF SIN3A ZBTB40 GLIS2 ATF7 ETV6 RUNX3 ZNF202 ZNF362 REST

Genomic Location for ITPKB Gene

Chromosome:
1
Start:
226,631,690 bp from pter
End:
226,739,327 bp from pter
Size:
107,638 bases
Orientation:
Minus strand

Genomic View for ITPKB Gene

Genes around ITPKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKB Gene

Proteins for ITPKB Gene

  • Protein details for ITPKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27987-IP3KB_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase B
    Protein Accession:
    P27987
    Secondary Accessions:
    • Q5VWL9
    • Q5VWM0
    • Q96BZ2
    • Q96JS1
    • Q9UH47

    Protein attributes for ITPKB Gene

    Size:
    946 amino acids
    Molecular mass:
    102376 Da
    Quaternary structure:
    • Interacts with DMTN.
    SequenceCaution:
    • Sequence=CAA40491.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ITPKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITPKB Gene

Selected DME Specific Peptides for ITPKB Gene

P27987:
  • EGNREDGYL
  • AKVWMIDFGKT
  • IDFGKTTPLP
  • VDPEAPTEEE
  • RTYLEEELTKAR
  • TLGFRIEGIKK
  • HEVIGSSLLF

Post-translational modifications for ITPKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKB Gene

Domains & Families for ITPKB Gene

Gene Families for ITPKB Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ITPKB Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P27987

UniProtKB/Swiss-Prot:

IP3KB_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKB: view

Function for ITPKB Gene

Molecular function for ITPKB Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-B
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.

Enzyme Numbers (IUBMB) for ITPKB Gene

Phenotypes From GWAS Catalog for ITPKB Gene

Gene Ontology (GO) - Molecular Function for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with ITPKB: view
genes like me logo Genes that share phenotypes with ITPKB: view

Animal Models for ITPKB Gene

MGI Knock Outs for ITPKB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITPKB
  • Applied Biological Materials Clones for ITPKB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKB Gene

Localization for ITPKB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPKB gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ITPKB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKB Gene

Pathways & Interactions for ITPKB Gene

genes like me logo Genes that share pathways with ITPKB: view

Gene Ontology (GO) - Biological Process for ITPKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002262 myeloid cell homeostasis IEA --
GO:0007165 signal transduction TAS 1654894
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ITPKB: view

No data available for SIGNOR curated interactions for ITPKB Gene

Drugs & Compounds for ITPKB Gene

(3) Drugs for ITPKB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
ATP Nutra Agonist 0

(4) Additional Compounds for ITPKB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0
genes like me logo Genes that share compounds with ITPKB: view

Transcripts for ITPKB Gene

mRNA/cDNA for ITPKB Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITPKB Gene

Inositol-trisphosphate 3-kinase B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITPKB
  • Applied Biological Materials Clones for ITPKB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKB Gene

No ASD Table

Relevant External Links for ITPKB Gene

GeneLoc Exon Structure for
ITPKB
ECgene alternative splicing isoforms for
ITPKB

Expression for ITPKB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITPKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITPKB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Bone marrow mesenchymal stem cell (9.2), and Spinal cord (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITPKB Gene



NURSA nuclear receptor signaling pathways regulating expression of ITPKB Gene:

ITPKB

SOURCE GeneReport for Unigene cluster for ITPKB Gene:

Hs.528087

Evidence on tissue expression from TISSUES for ITPKB Gene

  • Nervous system(4.7)
  • Blood(4.3)
  • Intestine(4.2)
  • Skin(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ITPKB: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPKB Gene

Orthologs for ITPKB Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPKB 33 34
  • 99.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ITPKB 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITPKB 33 34
  • 85 (n)
dog
(Canis familiaris)
Mammalia ITPKB 33 34
  • 82.86 (n)
mouse
(Mus musculus)
Mammalia Itpkb 33 16 34
  • 81.67 (n)
rat
(Rattus norvegicus)
Mammalia Itpkb 33
  • 80.74 (n)
oppossum
(Monodelphis domestica)
Mammalia ITPKB 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITPKB 33 34
  • 78.15 (n)
lizard
(Anolis carolinensis)
Reptilia ITPKB 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itpkb 33
  • 64.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13865 33
zebrafish
(Danio rerio)
Actinopterygii itpkb 33 34
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta IP3K2 35 33 34
  • 62.73 (n)
IP3K1 35
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea lfe-2 35 34
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3402 33
Species where no ortholog for ITPKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKB Gene

ENSEMBL:
Gene Tree for ITPKB (if available)
TreeFam:
Gene Tree for ITPKB (if available)

Paralogs for ITPKB Gene

Paralogs for ITPKB Gene

(3) SIMAP similar genes for ITPKB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITPKB: view

Variants for ITPKB Gene

Sequence variations from dbSNP and Humsavar for ITPKB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000044709 -- 226,641,759(+) CTGAG(A/G)AATAG intron-variant
rs1000052759 -- 226,740,488(+) TCTAG(C/T)CAAGA upstream-variant-2KB
rs1000066237 -- 226,668,116(+) GATTC(C/T)GATTT intron-variant
rs1000079343 -- 226,702,345(+) GTGAG(A/C/T)GGACA intron-variant
rs1000085783 -- 226,740,911(+) AGGTC(C/T)CTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ITPKB Gene

Variant ID Type Subtype PubMed ID
esv3589015 CNV loss 21293372
esv992736 CNV deletion 20482838
nsv1068547 CNV deletion 25765185
nsv1113222 CNV deletion 24896259
nsv1121714 CNV deletion 24896259
nsv1151390 CNV deletion 26484159
nsv470779 CNV loss 18288195
nsv473166 CNV novel sequence insertion 20440878
nsv4755 CNV insertion 18451855
nsv516277 CNV loss 19592680
nsv522446 CNV loss 19592680
nsv523759 CNV loss 19592680
nsv952129 CNV deletion 24416366

Variation tolerance for ITPKB Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.42; 97.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITPKB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKB Gene

Disorders for ITPKB Gene

Relevant External Links for ITPKB

Genetic Association Database (GAD)
ITPKB
Human Genome Epidemiology (HuGE) Navigator
ITPKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITPKB

No disorders were found for ITPKB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKB Gene

Publications for ITPKB Gene

  1. Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B. (PMID: 11846419) Dewaste V … Erneux C (Biochemical and biophysical research communications 2002) 3 4 22 60
  2. Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. (PMID: 1654894) Takazawa K … Erneux C (The Biochemical journal 1991) 2 3 4 60
  3. Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. (PMID: 23060452) Wieschhaus AJ … Chishti AH (The Journal of biological chemistry 2012) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for ITPKB Gene

  • Addgene plasmids for ITPKB

Sources for ITPKB Gene

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