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Aliases for ITPKA Gene

Aliases for ITPKA Gene

  • Inositol-Trisphosphate 3-Kinase A 2 3 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase A 2 3 4
  • InsP 3-Kinase A 3 4
  • IP3 3-Kinase A 3 4
  • EC 4 63
  • IP3K A 3 4
  • IP3-3KA 3
  • IP3KA 3

External Ids for ITPKA Gene

Previous GeneCards Identifiers for ITPKA Gene

  • GC15P037153
  • GC15P034681
  • GC15P039364
  • GC15P039502
  • GC15P039573
  • GC15P041786
  • GC15P018634

Summaries for ITPKA Gene

Entrez Gene Summary for ITPKA Gene

  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

GeneCards Summary for ITPKA Gene

ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Calcium signaling pathway. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKC.

Gene Wiki entry for ITPKA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKA Gene

Genomics for ITPKA Gene

Regulatory Elements for ITPKA Gene

Enhancers for ITPKA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITPKA on UCSC Golden Path with GeneCards custom track

Promoters for ITPKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITPKA on UCSC Golden Path with GeneCards custom track

Genomic Location for ITPKA Gene

41,493,393 bp from pter
41,503,559 bp from pter
10,167 bases
Plus strand

Genomic View for ITPKA Gene

Genes around ITPKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKA Gene

Proteins for ITPKA Gene

  • Protein details for ITPKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol-trisphosphate 3-kinase A
    Protein Accession:
    Secondary Accessions:
    • Q8TAN3

    Protein attributes for ITPKA Gene

    461 amino acids
    Molecular mass:
    51009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ITPKA Gene

neXtProt entry for ITPKA Gene

Proteomics data for ITPKA Gene at MOPED

Selected DME Specific Peptides for ITPKA Gene

Post-translational modifications for ITPKA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ITPKA

Domains & Families for ITPKA Gene

Gene Families for ITPKA Gene

Protein Domains for ITPKA Gene


Suggested Antigen Peptide Sequences for ITPKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol phosphokinase (IPK) family.
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKA: view

Function for ITPKA Gene

Molecular function for ITPKA Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-A
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin.

Enzyme Numbers (IUBMB) for ITPKA Gene

genes like me logo Genes that share phenotypes with ITPKA: view

Animal Models for ITPKA Gene

MGI Knock Outs for ITPKA:

Animal Model Products

miRNA for ITPKA Gene

miRTarBase miRNAs that target ITPKA

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKA Gene

Localization for ITPKA Gene

Subcellular locations from

Jensen Localization Image for ITPKA Gene COMPARTMENTS Subcellular localization image for ITPKA gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ITPKA Gene

Pathways & Interactions for ITPKA Gene

genes like me logo Genes that share pathways with ITPKA: view

SIGNOR curated interactions for ITPKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0061003 positive regulation of dendritic spine morphogenesis IEA --
genes like me logo Genes that share ontologies with ITPKA: view

Drugs & Compounds for ITPKA Gene

(6) Drugs for ITPKA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
D-Myo-Inositol-1,4,5-Triphosphate Experimental Pharma Target 0
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
calcium Nutra 0

(4) Additional Compounds for ITPKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
genes like me logo Genes that share compounds with ITPKA: view

Transcripts for ITPKA Gene

mRNA/cDNA for ITPKA Gene

Unigene Clusters for ITPKA Gene

Inositol-trisphosphate 3-kinase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKA Gene

No ASD Table

Relevant External Links for ITPKA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITPKA Gene

mRNA expression in normal human tissues for ITPKA Gene

mRNA differential expression in normal tissues according to GTEx for ITPKA Gene

This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x6.0), Brain - Putamen (basal ganglia) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ITPKA Gene

This gene is overexpressed in Monocytes (28.5), Frontal cortex (21.2), Plasma (11.4), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPKA Gene

SOURCE GeneReport for Unigene cluster for ITPKA Gene Hs.2722

genes like me logo Genes that share expression patterns with ITPKA: view

Protein tissue co-expression partners for ITPKA Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ITPKA Gene

Orthologs for ITPKA Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITPKA 35
  • 91.97 (n)
  • 96.1 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ITPKA 35
  • 91.97 (n)
  • 93.93 (a)
  • 94 (a)
(Mus musculus)
Mammalia Itpka 35
  • 87.94 (n)
  • 93.68 (a)
Itpka 16
Itpka 36
  • 94 (a)
(Pan troglodytes)
Mammalia ITPKA 35
  • 99.92 (n)
  • 100 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Itpka 35
  • 87.36 (n)
  • 93.9 (a)
(Monodelphis domestica)
Mammalia ITPKA 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ITPKA 36
  • 91 (a)
(Gallus gallus)
Aves ITPKA 35
  • 70.05 (n)
  • 72.84 (a)
IP3KA 36
  • 69 (a)
(Anolis carolinensis)
Reptilia ITPKA 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486229 35
  • 61.29 (n)
  • 63.23 (a)
(Danio rerio)
Actinopterygii LOC564528 35
  • 62.15 (n)
  • 61.85 (a)
wufi30c01 35
itpka 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta IP3K1 37
  • 44 (a)
IP3K2 37
  • 59 (a)
IP3K2 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002194 35
  • 57.89 (n)
  • 56.97 (a)
(Caenorhabditis elegans)
Secernentea lfe-2 37
  • 41 (a)
lfe-2 36
  • 26 (a)
Species with no ortholog for ITPKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKA Gene

Gene Tree for ITPKA (if available)
Gene Tree for ITPKA (if available)

Paralogs for ITPKA Gene

Paralogs for ITPKA Gene

(3) SIMAP similar genes for ITPKA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITPKA: view

Variants for ITPKA Gene

Sequence variations from dbSNP and Humsavar for ITPKA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12591235 -- 41,495,060(+) GAGAG(C/G)GGCGG intron-variant
rs1617832 -- 41,496,893(-) TCCAA(C/T)TGCCC intron-variant
rs1622914 -- 41,497,014(-) TCTGC(C/T)GGAGC intron-variant
rs1655557 -- 41,495,774(-) GCCCC(C/G)GGAGC intron-variant
rs1655558 -- 41,495,387(-) CCCGG(A/C)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPKA Gene

Variant ID Type Subtype PubMed ID
nsv524476 CNV Loss 19592680
dgv2362n71 CNV Loss 21882294
nsv471241 CNV Loss 18288195
esv33378 CNV Gain 17666407

Variation tolerance for ITPKA Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ITPKA Gene

Disorders for ITPKA Gene

Relevant External Links for ITPKA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITPKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKA Gene

Publications for ITPKA Gene

  1. Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. (PMID: 2175886) Takazawa K. … Erneux C. (Nucleic Acids Res. 1990) 2 3 4 67
  2. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C. … Mattei M.G. (Genomics 1992) 2 3 23
  3. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities. (PMID: 20022963) Windhorst S. … Mayr G.W. (J. Biol. Chem. 2010) 3 23
  4. Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. (PMID: 16525636) Kato H. … Tanzawa H. (Int. J. Oncol. 2006) 3 23
  5. Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus. (PMID: 11468283) Schell M.J. … Irvine R.F. (J. Biol. Chem. 2001) 3 23

Products for ITPKA Gene

Sources for ITPKA Gene