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Aliases for ITPKA Gene

Aliases for ITPKA Gene

  • Inositol-Trisphosphate 3-Kinase A 2 3
  • Inositol 1,4,5-Trisphosphate 3-Kinase A 2 3 4
  • InsP 3-Kinase A 3 4
  • IP3 3-Kinase A 3 4
  • EC 2.7.1.127 4 63
  • IP3K A 3 4
  • IP3-3KA 3
  • IP3KA 3

External Ids for ITPKA Gene

Previous GeneCards Identifiers for ITPKA Gene

  • GC15P037153
  • GC15P034681
  • GC15P039364
  • GC15P039502
  • GC15P039573
  • GC15P041786
  • GC15P018634

Summaries for ITPKA Gene

Entrez Gene Summary for ITPKA Gene

  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

GeneCards Summary for ITPKA Gene

ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calmodulin binding and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is ITPKC.

Gene Wiki entry for ITPKA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKA Gene

Genomics for ITPKA Gene

Regulatory Elements for ITPKA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPKA Gene

Start:
41,493,393 bp from pter
End:
41,503,559 bp from pter
Size:
10,167 bases
Orientation:
Plus strand

Genomic View for ITPKA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKA Gene

Proteins for ITPKA Gene

  • Protein details for ITPKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23677-IP3KA_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase A
    Protein Accession:
    P23677
    Secondary Accessions:
    • Q8TAN3

    Protein attributes for ITPKA Gene

    Size:
    461 amino acids
    Molecular mass:
    51009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ITPKA Gene

neXtProt entry for ITPKA Gene

Proteomics data for ITPKA Gene at MOPED

Selected DME Specific Peptides for ITPKA Gene

Post-translational modifications for ITPKA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ITPKA Gene

Gene Families for ITPKA Gene

Protein Domains for ITPKA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ITPKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23677

UniProtKB/Swiss-Prot:

IP3KA_HUMAN :
  • P23677
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKA: view

Function for ITPKA Gene

Molecular function for ITPKA Gene

GENATLAS Biochemistry: inositol 1,4,5-triphosphate 3 kinase-A
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: IP3K is activated by calmodulin

Enzyme Numbers (IUBMB) for ITPKA Gene

Gene Ontology (GO) - Molecular Function for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
GO:0048365 Rac GTPase binding IEA --
genes like me logo Genes that share ontologies with ITPKA: view
genes like me logo Genes that share phenotypes with ITPKA: view

Animal Models for ITPKA Gene

MGI Knock Outs for ITPKA:

Animal Model Products

CRISPR Products

miRNA for ITPKA Gene

miRTarBase miRNAs that target ITPKA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPKA

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ITPKA Gene

Localization for ITPKA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITPKA Gene COMPARTMENTS Subcellular localization image for ITPKA gene
Compartment Confidence
cytosol 4
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with ITPKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKA Gene

Pathways for ITPKA Gene

genes like me logo Genes that share pathways with ITPKA: view

Gene Ontology (GO) - Biological Process for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 1847047
GO:0016310 phosphorylation --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ITPKA: view

Compounds for ITPKA Gene

(5) HMDB Compounds for ITPKA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0

(4) Drugbank Compounds for ITPKA Gene

(3) Novoseek inferred chemical compound relationships for ITPKA Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4,5 trisphosphate 75.9 9
inositol 51.2 1
calcium 30 2
genes like me logo Genes that share compounds with ITPKA: view

Transcripts for ITPKA Gene

mRNA/cDNA for ITPKA Gene

Unigene Clusters for ITPKA Gene

Inositol-trisphosphate 3-kinase A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPKA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITPKA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKA Gene

No ASD Table

Relevant External Links for ITPKA Gene

GeneLoc Exon Structure for
ITPKA
ECgene alternative splicing isoforms for
ITPKA

Expression for ITPKA Gene

mRNA expression in normal human tissues for ITPKA Gene

mRNA differential expression in normal tissues according to GTEx for ITPKA Gene

This gene is overexpressed in Brain - Cortex (7.8), Brain - Frontal Cortex (BA9) (6.0), Brain - Putamen (basal ganglia) (5.6), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Caudate (basal ganglia) (4.5), and Brain - Nucleus accumbens (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPKA Gene

SOURCE GeneReport for Unigene cluster for ITPKA Gene Hs.2722

genes like me logo Genes that share expressions with ITPKA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ITPKA Gene

Orthologs for ITPKA Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPKA 35
  • 99.92 (n)
  • 100 (a)
ITPKA 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITPKA 35
  • 91.97 (n)
  • 96.1 (a)
ITPKA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITPKA 35
  • 91.97 (n)
  • 93.93 (a)
ITPKA 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpka 35
  • 87.94 (n)
  • 93.68 (a)
Itpka 16
Itpka 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITPKA 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITPKA 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itpka 35
  • 87.36 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves IP3KA 36
  • 69 (a)
OneToOne
ITPKA 35
  • 70.05 (n)
  • 72.84 (a)
lizard
(Anolis carolinensis)
Reptilia ITPKA 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486229 35
  • 61.29 (n)
  • 63.23 (a)
zebrafish
(Danio rerio)
Actinopterygii itpka 36
  • 48 (a)
OneToOne
LOC564528 35
  • 62.15 (n)
  • 61.85 (a)
wufi30c01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002194 35
  • 57.89 (n)
  • 56.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta IP3K2 36
  • 30 (a)
OneToMany
IP3K1 37
  • 44 (a)
IP3K2 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea lfe-2 36
  • 26 (a)
OneToMany
lfe-2 37
  • 41 (a)
Species with no ortholog for ITPKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKA Gene

ENSEMBL:
Gene Tree for ITPKA (if available)
TreeFam:
Gene Tree for ITPKA (if available)

Paralogs for ITPKA Gene

Paralogs for ITPKA Gene

Selected SIMAP similar genes for ITPKA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITPKA: view

Variants for ITPKA Gene

Sequence variations from dbSNP and Humsavar for ITPKA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1617832 -- 41,496,893(-) TCCAA(C/T)TGCCC intron-variant
rs1622914 -- 41,497,014(-) TCTGC(C/T)GGAGC intron-variant
rs1655557 -- 41,495,774(-) GCCCC(C/G)GGAGC intron-variant
rs1655558 -- 41,495,387(-) CCCGG(A/C)CTTAT intron-variant
rs1757456 -- 41,501,296(+) GCCAC(A/T)CAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ITPKA Gene

Variant ID Type Subtype PubMed ID
nsv524476 CNV Loss 19592680
dgv2362n71 CNV Loss 21882294
nsv471241 CNV Loss 18288195
esv33378 CNV Gain 17666407

Relevant External Links for ITPKA Gene

HapMap Linkage Disequilibrium report
ITPKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKA Gene

Disorders for ITPKA Gene

Relevant External Links for ITPKA

Genetic Association Database (GAD)
ITPKA
Human Genome Epidemiology (HuGE) Navigator
ITPKA
genes like me logo Genes that share disorders with ITPKA: view

No data available for UniProtKB/Swiss-Prot for ITPKA Gene

Publications for ITPKA Gene

  1. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C. … Mattei M.G. (Genomics 1992) 2 3 23
  2. Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. (PMID: 2175886) Takazawa K. … Erneux C. (Nucleic Acids Res. 1990) 2 3 4
  3. Molecular cloning and expression of a human brain inositol 1,4,5- trisphosphate 3-kinase. (PMID: 1847047) Takazawa K. … Erneux C. (Biochem. Biophys. Res. Commun. 1991) 3 4
  4. Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. (PMID: 15350214) Gonzalez B. … Williams R.L. (Mol. Cell 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ITPKA Gene

  • Addgene plasmids for ITPKA

Sources for ITPKA Gene

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