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Aliases for ITPKA Gene

Aliases for ITPKA Gene

  • Inositol-Trisphosphate 3-Kinase A 2 3 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase A 2 3 4
  • InsP 3-Kinase A 3 4
  • IP3 3-Kinase A 3 4
  • EC 2.7.1.127 4 61
  • IP3K A 3 4
  • IP3-3KA 3
  • IP3KA 3

External Ids for ITPKA Gene

Previous GeneCards Identifiers for ITPKA Gene

  • GC15P037153
  • GC15P034681
  • GC15P039364
  • GC15P039502
  • GC15P039573
  • GC15P041786
  • GC15P018634

Summaries for ITPKA Gene

Entrez Gene Summary for ITPKA Gene

  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

GeneCards Summary for ITPKA Gene

ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB.

Gene Wiki entry for ITPKA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKA Gene

Genomics for ITPKA Gene

Regulatory Elements for ITPKA Gene

Enhancers for ITPKA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F041560 1.2 Ensembl ENCODE 11.2 +69.8 69787 4.9 ATF1 ARID4B GLIS2 GATA2 ZNF263 SP5 REST SSRP1 SMARCA4 GLIS1 LTK RPAP1 ITPKA RNU6-1169P SPTBN5 PLA2G4B MAPKBP1 TYRO3 GC15M041574
GH15F041588 0.5 ENCODE 11.6 +96.5 96457 1.7 L3MBTL2 BHLHE40 SCRT2 ZBTB33 JMJD7 SPTBN5 TYRO3 ITPKA RPAP1 MGA LTK MAPKBP1 RNU6-1169P GC15P041578
GH15F041557 1.3 FANTOM5 ENCODE 1.6 +65.4 65426 3.2 ARID4B ZNF48 ZNF2 GLIS2 ZNF143 ZNF263 SP3 REST SMARCB1 GLIS1 RPAP1 TYRO3 MAPKBP1 ITPKA JMJD7 GC15M041574
GH15F041492 1.5 FANTOM5 ENCODE 0.8 +1.4 1427 5.1 ZFP64 ARID4B DMAP1 ZNF2 YY1 SLC30A9 KLF13 ZNF263 SP3 SP5 NDUFAF1 RTF1 RAD51-AS1 RPAP1 ENSG00000260814 MAPKBP1 TYRO3 RNU6-1169P RPUSD2 ITPKA
GH15F041489 1.1 Ensembl ENCODE 0.8 -2.9 -2912 1.1 KLF17 RAD21 ZNF366 RCOR1 ETV6 FOS CREM ZNF362 CEBPB JUNB NDUFAF1 RTF1 ITPKA LOC105370790
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITPKA on UCSC Golden Path with GeneCards custom track

Promoters for ITPKA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000406818 607 2001 ZFP64 ARID4B DMAP1 KLF13 ZNF263 SP3 SP5 MXD4 REST SMARCB1

Genomic Location for ITPKA Gene

Chromosome:
15
Start:
41,493,393 bp from pter
End:
41,503,559 bp from pter
Size:
10,167 bases
Orientation:
Plus strand

Genomic View for ITPKA Gene

Genes around ITPKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKA Gene

Proteins for ITPKA Gene

  • Protein details for ITPKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23677-IP3KA_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase A
    Protein Accession:
    P23677
    Secondary Accessions:
    • Q8TAN3

    Protein attributes for ITPKA Gene

    Size:
    461 amino acids
    Molecular mass:
    51009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ITPKA Gene

neXtProt entry for ITPKA Gene

Selected DME Specific Peptides for ITPKA Gene

P23677:
  • EGNREDGYL
  • IDFGKTTPLP
  • VDPEAPTEEE
  • RTYLEEELTKAR
  • TLGFRIEGIKK
  • HEVIGSSLLF

Post-translational modifications for ITPKA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ITPKA
  • Santa Cruz Biotechnology (SCBT) Antibodies for ITPKA

Domains & Families for ITPKA Gene

Gene Families for ITPKA Gene

Protein Domains for ITPKA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ITPKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23677

UniProtKB/Swiss-Prot:

IP3KA_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKA: view

Function for ITPKA Gene

Molecular function for ITPKA Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-A
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin.

Enzyme Numbers (IUBMB) for ITPKA Gene

Gene Ontology (GO) - Molecular Function for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA,TAS --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ITPKA: view
genes like me logo Genes that share phenotypes with ITPKA: view

Animal Models for ITPKA Gene

MGI Knock Outs for ITPKA:

Animal Model Products

miRNA for ITPKA Gene

miRTarBase miRNAs that target ITPKA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITPKA

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKA Gene

Localization for ITPKA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPKA gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with ITPKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKA Gene

Pathways & Interactions for ITPKA Gene

genes like me logo Genes that share pathways with ITPKA: view

SIGNOR curated interactions for ITPKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 1847047
GO:0016310 phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ITPKA: view

Drugs & Compounds for ITPKA Gene

(7) Drugs for ITPKA Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
D-Myo-Inositol-1,4,5-Triphosphate Experimental Pharma Target 0
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
calcium Nutra 0

(4) Additional Compounds for ITPKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0

(1) ApexBio Compounds for ITPKA Gene

Compound Action Cas Number
BAMB-4 ITPKA inhibitor,membrane-permeable 891025-25-5
genes like me logo Genes that share compounds with ITPKA: view

Transcripts for ITPKA Gene

mRNA/cDNA for ITPKA Gene

Unigene Clusters for ITPKA Gene

Inositol-trisphosphate 3-kinase A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITPKA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKA Gene

No ASD Table

Relevant External Links for ITPKA Gene

GeneLoc Exon Structure for
ITPKA
ECgene alternative splicing isoforms for
ITPKA

Expression for ITPKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITPKA Gene

mRNA differential expression in normal tissues according to GTEx for ITPKA Gene

This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x6.0), Brain - Putamen (basal ganglia) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ITPKA Gene

This gene is overexpressed in Monocytes (28.5), Frontal cortex (21.2), Plasma (11.4), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITPKA Gene



Protein tissue co-expression partners for ITPKA Gene

NURSA nuclear receptor signaling pathways regulating expression of ITPKA Gene:

ITPKA

SOURCE GeneReport for Unigene cluster for ITPKA Gene:

Hs.2722
genes like me logo Genes that share expression patterns with ITPKA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ITPKA Gene

Orthologs for ITPKA Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPKA 34 35
  • 99.92 (n)
cow
(Bos Taurus)
Mammalia ITPKA 34 35
  • 91.97 (n)
dog
(Canis familiaris)
Mammalia ITPKA 34 35
  • 91.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ITPKA 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itpka 34 16 35
  • 87.94 (n)
rat
(Rattus norvegicus)
Mammalia Itpka 34
  • 87.36 (n)
oppossum
(Monodelphis domestica)
Mammalia ITPKA 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITPKA 34
  • 70.05 (n)
IP3KA 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITPKA 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486229 34
  • 61.29 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564528 34
  • 62.15 (n)
itpka 35
  • 48 (a)
OneToOne
wufi30c01 34
fruit fly
(Drosophila melanogaster)
Insecta IP3K2 36 35
  • 59 (a)
IP3K1 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002194 34
  • 57.89 (n)
worm
(Caenorhabditis elegans)
Secernentea lfe-2 36 35
  • 41 (a)
Species where no ortholog for ITPKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKA Gene

ENSEMBL:
Gene Tree for ITPKA (if available)
TreeFam:
Gene Tree for ITPKA (if available)

Paralogs for ITPKA Gene

Paralogs for ITPKA Gene

(3) SIMAP similar genes for ITPKA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITPKA: view

Variants for ITPKA Gene

Sequence variations from dbSNP and Humsavar for ITPKA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111404506 -- 41,493,163(+) CCGAG(C/G/T)TCCTA upstream-variant-2KB
rs111657302 -- 41,502,785(+) CTCTG(C/G/T)AGAGG intron-variant
rs111678870 -- 41,502,890(+) GGGCC(A/G)CGAGG intron-variant
rs111840523 -- 41,492,114(+) ATAGC(G/T)TATGA upstream-variant-2KB
rs112192533 -- 41,501,314(+) TAAAC(C/G)TTCCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ITPKA Gene

Variant ID Type Subtype PubMed ID
esv33378 CNV gain 17666407
nsv471241 CNV loss 18288195
nsv524476 CNV loss 19592680
nsv569233 CNV loss 21841781

Variation tolerance for ITPKA Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITPKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKA Gene

Disorders for ITPKA Gene

Relevant External Links for ITPKA

Genetic Association Database (GAD)
ITPKA
Human Genome Epidemiology (HuGE) Navigator
ITPKA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITPKA

No disorders were found for ITPKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKA Gene

Publications for ITPKA Gene

  1. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C. … Mattei M.G. (Genomics 1992) 2 3 22 64
  2. Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. (PMID: 2175886) Takazawa K. … Erneux C. (Nucleic Acids Res. 1990) 2 3 4 64
  3. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities. (PMID: 20022963) Windhorst S. … Mayr G.W. (J. Biol. Chem. 2010) 3 22 64
  4. Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. (PMID: 16525636) Kato H. … Tanzawa H. (Int. J. Oncol. 2006) 3 22 64
  5. Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. (PMID: 15350214) Gonzalez B. … Williams R.L. (Mol. Cell 2004) 3 4 64

Products for ITPKA Gene

Sources for ITPKA Gene

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