ITPK1 Gene
protein-coding GIFtS : 59 GCID: GC14 M093403
inositol-tetrakisphosphate 1-kinase inositol 1,3,4-triphosphate 5/6 kinase )
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Aliasesfor ITPK1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Inositol-Tetrakisphosphate 1-Kinase 1 2 ITRPK12 Inositol 1,3,4-Triphosphate 5/6 Kinase1 2 Inositol 1,3,4-Trisphosphate 5/6 Kinase2 Inositol 1,3,4-Trisphosphate 5/6-Kinase2 3 EC 2.7.1.1343 Inositol-Triphosphate 5/6-Kinase2 3 EC 2.7.1.1593 Ins(1,3,4)P(3) 5/6-Kinase2 3
Export aliases for ITPK1 gene to outside databases Previous GC identifers: GC14M090910 GC14M087219 GC14M091393 GC14M091394 GC14M092473 GC14M073584
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Summariesfor ITPK1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ITPK1_HUMAN, Q13572 Function : Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain Gene Wiki entry for ITPK1
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Genomic Viewsfor ITPK1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ITPK1 gene promoter:AML1a HNF-4alpha2 E4BP4 Arnt HNF-4alpha1 Evi-1 MEF-2A aMEF-2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for ITPK1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q31 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.12 ITPK1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M093403: view genomic region
(about GC identifiers )
Start: 93,403,259 bp from pter End:
93,582,665 bp from pter
Size: 179,407 bases Orientation:
minus strand
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Proteinsfor ITPK1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ITPK1_HUMAN, Q13572 See
protein sequence )Recommended Name: Size : 414 amino acids; 45621 DaCofactor : Binds 2 magnesium ions per subunitSubunit : Monomer. Interacts with GPS1/COPS1Caution : PubMed:11533064 detected some protein kinase activity and ability to phosphorylate transcription factorsc-jun/JUN and ATF2. However, PubMed:15762844 showed that it does not have protein kinase activity
3 PDB 3D structures from :2ODT (3D) 2Q7D (3D) 2QB5 (3D) Secondary accessions : Q9BTL6 Q9H2E7Alternative splicing : 2 isoforms : Q13572-1 Q13572-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ITPK1: NX_Q13572 Post-translational modifications:
Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT11 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q13572 ITPK1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001136065.1 NP_001136066.1 NP_055031.2 ENSEMBL proteins: ENSP00000346272 ENSP00000451091 ENSP00000451893 ENSP00000267615 ENSP00000451154 ENSP00000451323 ENSP00000452258 ENSP00000452230 ENSP00000450421 Reactome Protein details: Q13572 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing ITPK1 Antibody Products: Assay Products for ITPK1:
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Protein
Domains /for ITPK1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q13572 ProtoNet protein and cluster: Q13572
UniProtKB/Swiss-Prot: ITPK1_HUMAN, Q13572 Similarity : Belongs to the ITPK1 familySimilarity : Contains 1 ATP-grasp domain
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Functionfor ITPK1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ITPK1_HUMAN, Q13572 Function : Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain Catalytic activity : ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphateCatalytic activity : ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphateCatalytic activity : ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphateBiophysicochemical properties : Kinetic parameters: KM=0.3 uM for Ins(1,3,4)P3; KM=0.1 uM for Ins(3,4,5,6)P4; Vmax=320pmol/min/ug enzyme with Ins(1,3,4)P3 as substrate; Vmax=780 pmol/min/ug enzyme enzyme with Ins(3,4,5,6)P4 as substrate; Enzyme Numbers (IUBMB): EC 2.7.1.134 1 EC 2.7.1.159 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ITPK1 (NM_001142593 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITPK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITPK1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPK1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing 5 GenomeRNAi human phenotypes for ITPK1 :Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itpk1) :About GeneDecksing
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Pathways & Interactionsfor ITPK1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 2 Inositol phosphate metabolism 3 Metabolism 4 Synthesis of IP3 and IP4 in the cytosol 5 Factors involved in megakaryocyte development and platelet production
Pathway sources See GeneCards unified pathways Show all pathways 5 5/6 (see all 6 )3 (Kegg details for ITPK1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITPK1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/551 Interacting proteins for ITPK1 (Q13572 2 , 3 ENSP00000267615 4 via UniProtKB, MINT, STRING , and/or I2D (see all 551 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
About GeneDecksing
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Drugs & Compoundsfor ITPK1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ITPK1 9 HMDB Compounds for ITPK1 About this table Compound Synonyms
CAS
# PubMed Ids 1D-Myo-inositol 1,3,4,6-tetrakisphosphate 1D-Myo-inositol 1,3,4,6-tetrakisphosphate (see all 6 ) 110298-84-5 -- ADP adenosindiphosphorsaeure (see all 8 ) 58-64-0 -- Adenosine triphosphate 5'-(tetrahydrogen triphosphate) Adenosine (see all 24 ) 56-65-5 -- D-Myo-inositol 3,4,5,6-tetrakisphosphate 1D-myo-Inositol 3,4,5,6-tetrakisphosphate (see all 4 ) 112791-61-4 -- Inositol 1,3,4,5,6-pentakisphosphate 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate (see all 5 ) 20298-95-7 -- Inositol 1,3,4,5-tetraphosphate 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16 ) 102850-29-3 -- Inositol 1,3,4-trisphosphate 1,3,4-Itp (see all 8 ) 98102-63-7 -- Magnesium Magnesium (see all 2 ) 7439-95-4 -- Tetrahydropteridine 5,6,7,8-Tetrahydropteridine (see all 4 ) 10593-78-9 --
ITPK1
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Transcriptsfor ITPK1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ITPK1 gene (3 alternative transcripts): NM_001142593.1 NM_001142594.1 NM_014216.4 Unigene Cluster for ITPK1:
Inositol-tetrakisphosphate 1-kinase Hs.308122 [show with all ESTs ] Unigene Representative Sequence: NM_014216 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000354313 (uc001ybe.2 ) ENST00000556603 (uc001ybh.3 ) ENST00000555495 ENST00000267615 (uc001ybf.3 uc001ybg.3 ) ENST00000556954 ENST00000553695 ENST00000554999 ENST00000556185 ENST00000555553 ENST00000553452 ENST00000557309 ENST00000553655 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ITPK1 (NM_001142593 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITPK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITPK1
Additional cDNA sequence: AF279372.1 AK293515.1 AY129028.1 BC003622.2 BC007428.2 BC018192.1 BC037305.2 U51336.1
17 DOTS entries : DT.100668958 DT.97808493
DT.448043 DT.95158609 DT.100811893 DT.100811890 DT.100763224 DT.100811891 DT.70103261 DT.92443694 DT.100811895 DT.91785687 DT.91882783 DT.95158614 DT.95158615 DT.97797058 DT.91699787 24/440 AceView cDNA sequences (see all 440 ):
F11090 BQ948259 AI924938 AI700178 BU178327 BQ947907 AI983606 AI342749 AW250802 BE855745 NM_014216 CR594461 AI421303 AI674269 BU956956 AL119879 Z38974 AI919485 AA402726 BI861566 BU521724 BM471100 AW002263 BE732545 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ITPK1 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 SP1 : - SP2 :
ECgene alternative splicing isoforms for ITPK1
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Expression for ITPK1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ITPK1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGCTCAAGT
About this image ITPK1 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Brain Cerebral Cortex Brain Expression: Experimental details:
In-situ hybridization
See ITPK1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ITPK1 SOURCE GeneReport for Unigene cluster: Hs.308122 UniProtKB/Swiss-Prot: ITPK1_HUMAN, Q13572 Tissue specificity : Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. Inbrain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen SABiosciences Custom PCR Arrays for ITPK1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPK1
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Orthologsfor ITPK1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ITPK1 gene from 8/24 species (see all 24 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Itpk11 5
inositol 1,3,4-triphosphate 5/6 kinase1, 5
88.24(n) 1 93.96(a) 1
12 (51.69 cM) 5 217837 1 NM_172584.3 1 NP_766172.1 1 102568582 5
chicken Aves ITPK11
inositol-tetrakisphosphate 1-kinase
77.64(n) 84.28(a)
423421 NM_001012588.1 NP_001012606.1
lizard Reptilia ITPK16
--
80(a)
1 ↔ 1
1(11060170-11114968)
African clawed frog Amphibia BC054977.12
--
79.38(n)
BC054977.1
zebrafish Actinopterygii BC050497.12
--
76.57(n)
BC050497.1
honey bee Insecta --
--
36(a)
1 ↔ 1
GroupUn.70(149476-151147)
thale cress eudicotyledons AT4G337701
inositol-tetrakisphosphate 1-kinase 3
42.6(n) 33.56(a)
829519 NM_119535.4 NP_195103.3
rice Liliopsida ----(see all 6 )
Inositol 1, 3, 4-trisphosphate 5/6-kinase, putativ... Inositol 1, 3, 4-trisphosphate 5/6-kinase, putativ... (see all 6 )28(a) 27(a) (see all 6 )
many → 1many → 1(see all 6 )
10(300771-307113) 3(29529011-29536314)
ENSEMBL Gene Tree for ITPK1 (if available)TreeFam Gene Tree for ITPK1 (if available)
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Paralogsfor ITPK1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ITPK1 gene About GeneDecksing 1 Pseudogenes.org Pseudogene for ITPK1 PGOHUM00000241269
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Genomic Variantsfor ITPK1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 14 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ITPK1 (93403259 - 93582665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 11 variations for ITPK1 11 CNVs 29958 29957 5765 49441 66695 71941 49442 49445 49444 29959 49443
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ITPK1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601838
OMIM disorders : --3 : About MalaCards neural tube defect kidney disease cerebritis Human Genome Epidemiology (HuGE) Navigator: ITPK1 (4 documents) Export disorders for ITPK1 gene to outside databases
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Publicationsfor ITPK1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ITPK1 gene, integrated from 9 sources (see all 23 ):(articles sorted by number of sources associating them with ITPK1) Utopia : connect your pdf to the dynamic
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase. (PubMed id 11042108) 1 , 2 , 3(2000) Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. (PubMed id 8662638) 1 , 2 , 3(1996) Integration of inositol phosphate signaling pathways via human ITPK1. (PubMed id 17616525) 1 , 2 , 9(2007) Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation. (PubMed id 22308441) 1 , 2 (2012) The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase. (PubMed id 15762844) 1 , 2 (2005) Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. (PubMed id 15837423) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis. (PubMed id 12925536) 1 , 2 (2003) Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. (PubMed id 12324474) 1 , 2 (2002) Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. (PubMed id 11909533) 1 , 2 (2002)
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External Searches for ITPK1 gene
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Genome Databases showing ITPK1 gene
(According to
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ECgene ,
Kegg ,
and/or
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Specialized Databases showing ITPK1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ITPK1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ITPK1 gene: ITPK1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ITPK1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ITPK1 OriGene shRNA RFP for ITPK1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ITPK1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ITPK1 OriGene 3'-UTR Clone for ITPK1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ITPK1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ITPK1 OriGene Custom Protein Services for ITPK1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITPK1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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