Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITPA Gene

protein-coding GIFtS: 70
GCID: GC20P003189

Inosine Triphosphatase (Nucleoside Triphosphate Pyrophosphatase)

(Previous symbol: C20orf37)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Inosine Triphosphatase (Nucleoside Triphosphate Pyrophosphatase)¹ ²		HLC14-06-P²
C20orf37¹ ² ³		dJ794I6.3²
Non-Canonical Purine NTP Pyrophosphatase² ³		Inosine Triphosphatase-A²
Non-Standard Purine NTP Pyrophosphatase² ³		Inosine Triphosphate Pyrophosphatase²
Nucleoside-Triphosphate Diphosphatase² ³		Inosine Triphosphate Pyrophosphohydrolase²
Putative Oncogene Protein Hlc14-06-P² ³		Inosine Triphosphatase³
ITPase² ³		Nucleoside-Triphosphate Pyrophosphatase³
NTPase² ³		EC 3.6.1⁸
EC 3.6.1.19³ ⁸

External Ids:	HGNC: 6176¹	Entrez Gene: 3704²	Ensembl: ENSG00000125877⁷	OMIM: 147520⁵	UniProtKB: Q9BY32³

Export aliases for ITPA gene to outside databases

Previous GC identifers: GC20P003178 GC20P003185 GC20P003138

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITPA Gene:

This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine

triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which

is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the

encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of

ITP in red blood cells. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jun

2012)

GeneCards Summary for ITPA Gene:

ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) is a protein-coding gene. Diseases associated with ITPA include inosine triphosphate pyrophosphohydrolase deficiency, and leukopenia, and among its related super-pathways are Purine metabolism and Metabolic pathways. GO annotations related to this gene include dITP diphosphatase activity and nucleotide binding.

UniProtKB/Swiss-Prot: ITPA_HUMAN, Q9BY32

Function: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP),

deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine

5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the

deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus

preventing their incorporation into RNA and DNA and avoiding chromosomal lesions

Gene Wiki entry for ITPA Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.2 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITPA gene promoter:
AhR Max1 USF1 AML1a MIF-1 Arnt USF-1 Sox9 c-Myb c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITPA promoter sequence

Search SABiosciences Chromatin IP Primers for ITPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p

ITPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITPA gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P003189: view genomic region (about GC identifiers)

Start:	3,189,514 bp from pter	End:	3,204,516 bp from pter
Size:	15,003 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITPA_HUMAN, Q9BY32 (See protein sequence)

Recommended Name: Inosine triphosphate pyrophosphatase

Size: 194 amino acids; 21446 Da

Cofactor: Binds 1 magnesium ion per subunit

Subunit: Homodimer

Subcellular location: Cytoplasm

4 PDB 3D structures from and Proteopedia for ITPA:

2CAR (3D)

2I5D (3D)

2J4E (3D)

4F95 (3D)

Secondary accessions: A2A2N2 A4UIM5 B2BCH7 O14878 Q5JWH4 Q9BYN1 Q9BYX0 Q9H3H8

Alternative splicing: 3 isoforms: Q9BY32-1 Q9BY32-2 Q9BY32-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITPA: NX_Q9BY32

Explore proteomics data for ITPA at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BY32

3 DME Specific Peptides for ITPA (Q9BY32)

KIVFVTGN

GPVLVEDTCLCFNAL

KKIVFVTGNAKKLEE

ITPA Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001254552.1 NP_258412.1 NP_852470.1

ENSEMBL proteins:

ENSP00000369456 ENSP00000382732 ENSP00000413282

Reactome Protein details: Q9BY32
Human Recombinant Protein Products for ITPA:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for ITPA OriGene Protein Over-expression Lysate for ITPA OriGene MassSpec for ITPA OriGene Custom Protein Services for ITPA
	GenScript Custom Purified and Recombinant Proteins Services for ITPA
	Novus Biologicals ITPA Proteins Novus Biologicals ITPA Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for ITPA
	Cloud-Clone Corp. Proteins for ITPA

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

ITPA for ontologies About GeneDecksing

ITPA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITPA
	Browse R&D Systems for Antibodies
	OriGene Antibodies for ITPA OriGene Custom Antibody Services for ITPA
	GenScript Custom Superior Antibodies Services for ITPA
	Novus Biologicals ITPA Antibodies
	Abcam antibodies for ITPA
	Cloud-Clone Corp. Antibodies for ITPA
	ThermoFisher Antibody for ITPA
	LSBio Antibodies in human, mouse, rat for ITPA

Assay Products for ITPA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ITPA
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITPA
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ITPA Cloud-Clone Corp. CLIAs for ITPA

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR027502 ITPase

IPR002637 Ham1p-like

Graphical View of Domain Structure for InterPro Entry Q9BY32

ProtoNet protein and cluster: Q9BY32

1 Blocks protein domain: IPB002637 Ham1-like protein

UniProtKB/Swiss-Prot: ITPA_HUMAN, Q9BY32

Similarity: Belongs to the HAM1 NTPase family

ITPA for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ITPA_HUMAN, Q9BY32

Function: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP),

deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine

5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the

deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus

preventing their incorporation into RNA and DNA and avoiding chromosomal lesions

Catalytic activity: A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate

Biophysicochemical properties: Kinetic parameters: KM=0.51 mM for ITP; KM=0.31 mM for dITP; KM=0.57 mM for XTP;

KM=40.7 uM for dHAPTP; KM=933 uM for dGTP; Vmax=1520 umol/min/mg enzyme for ITP; Vmax=940 umol/min/mg enzyme for

dITP; Vmax=1680 umol/min/mg enzyme for XTP; Note=Vmax values are similar for dITP, dHAPTP and dGTP; pH

dependence: Optimum pH is 10;

Genatlas biochemistry entry for ITPA:

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Enzyme Numbers (IUBMB): EC 3.6.1.19¹ ² EC 3.6.1²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0016787	hydrolase activity	--	--
GO:0035870	dITP diphosphatase activity	EXP	--
GO:0036220	ITP diphosphatase activity	EXP	--
GO:0036222	XTP diphosphatase activity	EXP	--

ITPA for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ITPA:

Increased gamma-H2AX phosphory

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Itpa):

behavior/neurological	cardiovascular system	cellular	growth/size	hematopoietic system
integument	mortality/aging	muscle	reproductive system	respiratory system

ITPA for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Itpa^tm1Skmi for ITPA

inGenious Targeting Laboratory - Custom generated mouse model solutions for ITPA

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITPA

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITPA

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITPA

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITPA
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPA:
		hsa-miR-2355-5p hsa-miR-1252
		SwitchGear 3'UTR luciferase reporter plasmid: ITPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ITPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITPA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ITPA
			Sirion Biotech Customized adenovirus for overexpression of ITPA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for ITPA (see all 13) OriGene ORF clones in mouse, rat for ITPA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ITPA (NM_033453)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPA
		Sirion Biotech Customized lentivirus for stable overexpression of ITPA Customized lentivirus expression plasmids for stable overexpression of ITPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITPA
		Search LifeMap BioReagents cell lines for ITPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ITPA About

See pathways by source

SuperPath

Contained pathways About

Purine metabolism

	Purine metabolism	0.38			ATP/ITP metabolism	0.31
	Pyrimidine metabolism	0.38

Metabolism

Metabolism

0.40

Metabolic pathways

0.40

Purine metabolism

Metabolism of nucleotides

0.42

Antimetabolite Pathway - Folate Cycle, Pharmacodynamics

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

0.36

Glucuronidation

Drug metabolism - other enzymes

0.33

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for ITPA

ATP/ITP metabolism

1 GeneGo (Thomson Reuters) Pathway for ITPA

ATP/ITP metabolism

2 Reactome Pathways for ITPA

	Metabolism of nucleotides
	Metabolism

1 PharmGKB Pathway for ITPA

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

4 Kegg Pathways (Kegg details for ITPA):

	Purine metabolism
	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

ITPA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/168 Interacting proteins for ITPA (Q9BY32³ ENSP00000369456⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 168)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP6V1B2	P21281³, ENSP00000276390⁴	I2D: score=4 STRING: ENSP00000276390
RUVBL1	Q9Y265³, ENSP00000318297⁴	I2D: score=1 STRING: ENSP00000318297
CAD	P27708³, ENSP00000264705⁴	I2D: score=1 STRING: ENSP00000264705
HSP90AA1	P07900³	I2D: score=3
RPS24	P62847³	I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006193	ITP catabolic process	IEA	--
GO:0009204	deoxyribonucleoside triphosphate catabolic process	IEA	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0051276	chromosome organization	IEA	--
GO:0055086	nucleobase-containing small molecule metabolic process	TAS	--

ITPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITPA

10/24 HMDB Compounds for ITPA (see all 24) About this table

Compound	Synonyms	CAS #	PubMed Ids
2'-Deoxyguanosine 5'-monophosphate	2'-Deoxy-5'-GMP (see all 21)	902-04-5	--
2'-Deoxyinosine triphosphate	2'-Deoxyinosine-5'-triphosphate (see all 6)	16595-02-1	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Inosine triphosphate	inosine 5'-(tetrahydrogen triphosphate) (see all 13)	132-06-9	--
Inosinic acid	5'-IMP (see all 9)	131-99-7	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for ITPA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Citric Acid	--	77-92-9	target	--	10592235

10/15 Novoseek inferred chemical compound relationships for ITPA gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inosine triphosphate	99.3	142	17697207 (4), 11278832 (3), 15167706 (2), 15243983 (2) (see all 43)
thiopurine	96	63	17697198 (6), 19960028 (3), 16431304 (2), 18223458 (2) (see all 28)
xanthosine 5'-triphosphate	92.5	5	16384889 (1), 9337071 (1), 18600522 (1)
6 mercaptopurine	87.2	30	18685564 (5), 20021291 (3), 15571266 (1), 19151640 (1) (see all 8)
inosine	77.9	23	17138556 (4), 17924837 (2), 18223458 (2), 18616518 (1) (see all 10)
inosine monophosphate	77.8	12	16384889 (1), 20205660 (1), 18062990 (1), 15946879 (1) (see all 7)
azathioprine	72.3	22	15167706 (4), 16611274 (4), 16431304 (3), 15973722 (3) (see all 8)
azathioprine	70.1	19	19229528 (4), 19214663 (3), 20367526 (3), 18090994 (1) (see all 7)
6 thioguanine	64.1	3	15167706 (1), 16918876 (1), 15571265 (1)
pyrophosphate	44.6	3	15946879 (1), 19914375 (1)

4 PharmGKB related drug/compound annotations for ITPA gene About this table

Drug/compound	PharmGKB Annotation
interferon alfa-2b, recombinant	CA
azathioprine	CA
methotrexate	CA
ribavirin	CA

Search CenterWatch for drugs/clinical trials and news about ITPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITPA gene (3 alternative transcripts):

NM_001267623.1 NM_033453.3 NM_181493.2

Unigene Cluster for ITPA:

Inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Hs.415299 [show with all ESTs]

Unigene Representative Sequence: BM918059

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483354 ENST00000460676 ENST00000380113(uc002wie.3 uc002wid.3)

ENST00000490838(uc002wif.3) ENST00000460550 ENST00000399838 ENST00000461029

ENST00000472295 ENST00000455664

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITPA
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ITPA:
		hsa-miR-2355-5p hsa-miR-1252
		SwitchGear 3'UTR luciferase reporter plasmid: ITPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ITPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITPA

Clone Products:		OriGene clones in human, mouse for ITPA (see all 13) OriGene ORF clones in mouse, rat for ITPA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ITPA (NM_033453)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPA
		Sirion Biotech Customized lentivirus for stable overexpression of ITPA Customized lentivirus expression plasmids for stable overexpression of ITPA

Primer Products:		OriGene qPCR primer pairs and template standards for ITPA OriGene qSTAR qPCR primer pairs in human, mouse for ITPA
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPA

Additional mRNA sequence:

AB062127.1 AF026816.2 AF063607.1 AF219116.1 AF334680.1 AK309165.1 BC010138.2 EF199841.1

EF213026.1 NR_052000.1 NR_052001.1 NR_052002.1

15 DOTS entries:

DT.100802896 DT.452584 DT.92434627 DT.100802893 DT.40253236 DT.40305266 DT.92434612 DT.92434616

DT.100802901 DT.91934045 DT.92434624 DT.95332879 DT.95341588 DT.40193344 DT.431898

11 AceView cDNA sequences:

CR591168 CR607092 NM_181493 BC010138 CR595616 NM_033453 AF334680 AF026816

AB062127 AF219116 AF063607

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ITPA (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f
SP1:																	-										-
SP2:											-		-				-										-
SP3:													-				-										-
SP4:											-		-		-												-
SP5:																	-		-								-

ECgene alternative splicing isoforms for ITPA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITPA expression in normal human tissues (normalized intensities) ITPA embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTTTTTAAAT

About this image

ITPA expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/29 selected tissues (see all 29) fully expand


Brain (Nervous System) fully expand to see all 9 entries
Cerebral Cortex
brain/midbrain

Testis (Reproductive System) fully expand to see all 3 entries
Leydig Cells Testis Interstitium
testis ; cells in seminiferus ducts

Colon (Gastrointestinal Tract) fully expand to see all 3 entries
colon ; peripheral nerve/ganglion

Lung (Respiratory System) fully expand to see all 2 entries
bronchus ; respiratory epithelial cells

Uterus (Reproductive System) fully expand to see all 2 entries
uterus, post-menopause ; glandular cells

See ITPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITPA

SOURCE GeneReport for Unigene cluster: Hs.415299

UniProtKB/Swiss-Prot: ITPA_HUMAN, Q9BY32

Tissue specificity: Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland

SABiosciences Custom PCR Arrays for ITPA

Primer Products:		OriGene qPCR primer pairs and template standards for ITPA OriGene qSTAR qPCR primer pairs in human, mouse for ITPA
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ITPA gene from 10/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Itpa^{1 , 5}	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)^{1, 5}	84.46(n)¹ 89.64(a)¹		2 (63.24 cM)⁵ 16434¹ NM_025922.2¹ NP_080198.2¹ 130667610⁵
chicken (Gallus gallus)	Aves	ITPA¹	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	74.87(n) 78.07(a)		424390 XM_422234.3 XP_422234.1
lizard (Anolis carolinensis)	Reptilia	ITPA⁶	Uncharacterized protein	63(a)	1 ↔ 1	GL343300.1(1183563-1192305)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10054²	Xenopus laevis transcribed sequence with moderate similarity more	76.38(n)		BU907998.1
zebrafish (Danio rerio)	Actinopterygii	si:ch73-18j6.1¹	si:ch73-18j6.1	68.68(n) 75.27(a)		557834 NM_001099986.1 NP_001093456.1
fruit fly (Drosophila melanogaster)	Insecta	CG8891^{1 , 3}	CG8891¹	66(a)³ 66.3(n)¹ 67.21(a)¹		33718¹ NM_135046.4¹ NP_608890.1¹
worm (Caenorhabditis elegans)	Secernentea	hap-1^{1 , 3}	Protein HAP-1¹	61(a)³ 58.24(n)¹ 62.92(a)¹		III(5335392-5336749)³ 175724¹ NM_065720.2¹ NP_498121.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HAM1(YJR069C)⁴	Conserved protein with deoxyribonucleoside triphosphate more	--		10(569399-568806) 853532 NP_012603.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G13720¹	nucleoside-triphosphate pyrophosphatase	60.36(n) 61.62(a)		827006 NM_117446.2 NP_567410.1
rice (Oryza sativa)	Liliopsida	Os.46595²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	74.1(n)		AK059744.1

ENSEMBL Gene Tree for ITPA (if available)
TreeFam Gene Tree for ITPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1127354^1,2,4	C,F	Inosine triphosphate pyrophosphohydrolase deficiency (ITPAD)⁴ pathogenic¹	3137448(+)	`AGTTTA/C/G/T CATGC`	8	T P	mis¹ int¹		13		MN NS EA CSA WA NA EU	7326
rs145254749^1,2	C	--	3131125(+)	`TTAACC/GAGGCA`	1	--	us2k¹		0	--	--	--	--
rs181482500^1,2		--	3131207(+)	`GAGGTC/TGCAGT`	1	--	us2k¹		0	--	--	--	--
rs186596444^1,2		--	3131214(+)	`CAGTGA/TGCCGG`	1	--	us2k¹		0	--	--	--	--
rs66696167^1,2	C,F	--	3131218(+)	`GAGCCG/AGGACC`	1	--	us2k¹		7		NA WA EA	366
rs149180648^1,2		--	3131296(+)	`AATGAA/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs6139030^1,2	C,F,H	--	3131342(+)	`TGTGAT/CCTTTT`	1	--	us2k¹		17		NS EA NA CSA WA	2340
rs111386206^1,2	C,F	--	3131383(+)	`CTCACG/ATCACC`	1	--	us2k¹		1		NA	2
rs116936000^1,2	C,F	--	3131630(+)	`CCTACT/CATGTA`	4	--	us2k¹		1		EA	120
rs143342837^1,2		--	3131667(+)	`GGTGAA/GGCTGG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ITPA (3189514 - 3204516 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for ITPA: About this table

Variant ID	Type	Subtype	PubMed ID
dgv4520n71	CNV	Loss	21882294
nsv912604	CNV	Loss	21882294
dgv4519n71	CNV	Loss	21882294
nsv528355	CNV	Loss	19592680
nsv833898	CNV	Gain+Loss	17160897

Human Gene Mutation Database (HGMD): ITPA

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing ITPA

DNA2.0 Custom Variant and Variant Library Synthesis for ITPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 147520 OMIM disorders: --

UniProtKB/Swiss-Prot: ITPA_HUMAN, Q9BY32

Inosine triphosphate pyrophosphohydrolase deficiency (ITPAD) [MIM:613850]: A common inherited condition

characterized by the abnormal accumulation of inosine triphosphate in erythrocytes. It might have pharmacogenomic

implications and be related to increased drug toxicity of purine analog drugs. Note=The disease is caused by

mutations affecting the gene represented in this entry. Three different human populations have been reported with

respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated

with complete loss of enzyme activity, may be by altering the local secondary structure of the protein.

Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric

structure of the enzyme

20/27 diseases for ITPA (see all 27): About MalaCards

inosine triphosphate pyrophosphohydrolase deficiency leukopenia nodular regenerative hyperplasia adenosine deaminase deficiency

interstitial lung disease langerhans-cell histiocytosis pancytopenia histiocytosis

inflammatory bowel disease hemolytic anemia thrombocytopenia crohn's disease

acute lymphoblastic leukemia hepatitis c systemic lupus erythematosus lymphoblastic leukemia

pneumonia anemia lupus erythematosus tuberculosis

3 diseases from the University of Copenhagen DISEASES database for ITPA:

Hepatitis C Anemia Inflammatory bowel disease

ITPA for disorders About GeneDecksing

6 Novoseek inferred disease relationships for ITPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammatory bowel diseases	71.4	9	16611274 (2), 17697198 (2), 15167706 (1), 19960028 (1) (see all 6)
enzyme deficiency	56.8	2	17304144 (1)
leukopenia	45.5	2	19229528 (1), 17697207 (1)
colitis ulcerative	37.2	1	17697207 (1)
pancreatitis	32.6	2	15564886 (1)
hyperplasia	10.4	1	18090994 (1)

Genetic Association Database (GAD): ITPA
Human Genome Epidemiology (HuGE) Navigator: ITPA (40 documents)

Export disorders for ITPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITPA gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with ITPA)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene. (PubMed id 11278832)^{1, 2, 3, 9} Lin S.... Mao Y. (2001)
DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. (PubMed id 12436200)^{1, 2, 4, 9} Cao H. and Hegele R.A. (2002)
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. (PubMed id 12384777)^{1, 2, 9} Sumi S.... Duley J.A. (2002)
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). (PubMed id 15167706)^{1, 4, 9} Marinaki A.M....Sanderson J.D. (2004)
Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia. (PubMed id 18685564)^{1, 4, 9} Stocco G....Evans W. (2008)
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T. (PubMed id 17138556)^{1, 2, 9} Stenmark P.... Schueler H. (2007)
Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease. (PubMed id 17697198)^{1, 4, 9} Van Dieren J.M....Van der Woude C.J. (2007)
Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6. (PubMed id 17304144)^{1, 4, 9} Atanasova S....von Ahsen N. (2007)
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population. (PubMed id 15946879)^{1, 4, 9} Maeda T.... Togari H. (2005)
TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients. (PubMed id 19229528)^{1, 4, 9} Kurzawski M....Drozdzik M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3704	HGNC: 6176	AceView: ITPA	Ensembl:ENSG00000125877	euGenes: HUgn3704
ECgene: ITPA	Kegg: 3704	H-InvDB: ITPA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITPA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ITPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ITPA gene:
Search GeneIP for patents involving ITPA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITPA
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for ITPA		OriGene RNAi products in human, mouse, rat for ITPA
	OriGene qPCR primer pairs and template standards for ITPA		OriGene Protein Over-expression Lysate for ITPA
	OriGene MassSpec something-or-other for ITPA		OriGene clones in human, mouse for ITPA
	OriGene qSTAR qPCR primer pairs in human, mouse for ITPA		OriGene Purified Protein for ITPA
	OriGene ORF clones in mouse, rat for ITPA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ITPA		OriGene Custom Protein Services for ITPA

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITPA
	QIAGEN SeqTarget long-range PCR primers for resequencing ITPA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITPA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITPA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITPA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITPA

	GenScript Custom Purified and Recombinant Proteins Services for ITPA		GenScript cDNA clones with any tag delivered in your preferred vector for ITPA
	GenScript Custom Assay Services for ITPA		GenScript Custom Superior Antibodies Services for ITPA
	GenScript Custom overexpressing Cell Line Services for ITPA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ITPA promoter
	Search Chromatin IP Primers for ITPA
	RT² qPCR Primer Assay in human, mouse, rat ITPA
	GNC Network for ITPA
	SABiosciences Custom PCR Arrays for ITPA

Search Tocris compounds for ITPA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ITPA antibodies
	ITPA proteins
	ITPA lysates

	Antibodies for ITPA
	See all of Abcam's Antibodies, Kits and Proteins for ITPA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for ITPA

	Proteins for ITPA
	Antibodies for ITPA
	ELISAs for ITPA
	CLIAs for ITPA

Search LifeMap BioReagents cell lines for ITPA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITPA

	SwitchGear 3'UTR luciferase reporter plasmids for ITPA
	SwitchGear Promoter luciferase reporter plasmids for ITPA

ThermoFisher Antibody for ITPA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITPA

	inGenious Targeting Laboratory - Custom generated mouse model solutions for ITPA
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITPA

Customized:

	lentivirus for stable overexpression of ITPA
	lentivirus expression plasmids for stable overexpression of ITPA
	adenovirus for overexpression of ITPA

LSBio Antibodies in human, mouse, rat for ITPA

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ITPA gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ITPA Gene

Inosine Triphosphatase (Nucleoside Triphosphate Pyrophosphatase)

Aliases
for ITPA gene

Summaries
for ITPA gene

Genomic Views
for ITPA gene

Proteins
for ITPA gene

Protein Domains /
Families
for ITPA gene

Function
for ITPA gene

Pathways & Interactions
for ITPA gene

Drugs & Compounds
for ITPA gene

Transcripts
for ITPA gene

Expression
for ITPA gene

Orthologs
for ITPA gene

Paralogs
for ITPA gene

Genomic Variants
for ITPA gene

Disorders / Diseases
for ITPA gene

Publications
for ITPA gene

External Searches for ITPA gene

Genome Databases showing ITPA gene

Other Databases showing ITPA gene

Specialized Databases showing ITPA gene

Intellectual Property
for ITPA gene

Products
for ITPA gene

View Random Gene

Advanced Search

Export list of displayed genes

ITPA Gene

Inosine Triphosphatase (Nucleoside Triphosphate Pyrophosphatase)

Aliasesfor ITPA gene

Summariesfor ITPA gene

Genomic Viewsfor ITPA gene

Proteinsfor ITPA gene

Protein Domains /Familiesfor ITPA gene

Functionfor ITPA gene

Pathways & Interactionsfor ITPA gene

Drugs & Compoundsfor ITPA gene

Transcriptsfor ITPA gene

Expression for ITPA gene

Orthologsfor ITPA gene

Paralogsfor ITPA gene

Genomic Variantsfor ITPA gene

Disorders / Diseasesfor ITPA gene

Publicationsfor ITPA gene

External Searches for ITPA gene

Genome Databases showing ITPA gene

Other Databases showing ITPA gene

Specialized Databases showing ITPA gene

Intellectual Propertyfor ITPA gene

Productsfor ITPA gene

View Random Gene

Aliases
for ITPA gene

Summaries
for ITPA gene

Genomic Views
for ITPA gene

Proteins
for ITPA gene

Protein Domains /
Families
for ITPA gene

Function
for ITPA gene

Pathways & Interactions
for ITPA gene

Drugs & Compounds
for ITPA gene

Transcripts
for ITPA gene

Expression
for ITPA gene

Orthologs
for ITPA gene

Paralogs
for ITPA gene

Genomic Variants
for ITPA gene

Disorders / Diseases
for ITPA gene

Publications
for ITPA gene

Intellectual Property
for ITPA gene

Products
for ITPA gene