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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITM2C Gene

protein-coding   GIFtS: 51
GCID: GC02P231693

integral membrane protein 2C

 Explore 6 diseases affiliated with
ITM2C via our new
 Human Malady Compendium 
Biological research products
for ITM2C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Integral Membrane Protein 2C1 2     Cerebral Protein 142 3
BRI31 2 3 5     Transmembrane Protein BRI32 3
BRICD2C1 2     E25C2
E251 2     BRICHOS Domain Containing 2C2
ITM31 2     Integral Membrane Protein 32
HRPC.1050_D_41     

External Ids:    HGNC: 61751   Entrez Gene: 816182   Ensembl: ENSG000001359167   OMIM: 6095545   UniProtKB: Q9NQX73   

Export aliases for ITM2C gene to outside databases

Previous GC identifers: GC02U990099 GC02P230461 GC02P231932 GC02P231555 GC02P231437 GC02P223571


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITM2C_HUMAN, Q9NQX7
Function: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its
access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible,
suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and
neuronal differentiation (By similarity)

Gene Wiki entry for ITM2C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITM2C gene promoter:
         Spz1   Sp1   AP-1   SREBP-1c   MyoD   Tal-1beta   SREBP-1b   Arnt   SREBP-1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITM2C promoter sequence
   Search SABiosciences Chromatin IP Primers for ITM2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITM2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

ITM2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITM2C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P231693:  view genomic region     (about GC identifiers)

Start:
231,729,354 bp from pter      End:
231,743,963 bp from pter
Size:
14,610 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITM2C_HUMAN, Q9NQX7 (See protein sequence)
Recommended Name: Integral membrane protein 2C  
Size: 267 amino acids; 30224 Da
Subunit: Interacts with BACE1. Interacts with APP. Interacts with STMN2
Subcellular location: Lysosome membrane; Single-pass type II membrane protein (By similarity). Cell membrane;
Single-pass type II membrane protein
Secondary accessions: B3KPG4 Q4G0A8 Q53H84 Q6IAE7 Q86VK5 Q8N288 Q8TAW0 Q9BUP8
Alternative splicing: 3 isoforms:  Q9NQX7-1   Q9NQX7-2   Q9NQX7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITM2C: NX_Q9NQX7

Post-translational modifications:

  • Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and
  • PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.
    Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQX7

  • ITM2C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012532.1  NP_001012534.1  NP_112188.1  

    ENSEMBL proteins: 
     ENSP00000390655   ENSP00000440295   ENSP00000322730   ENSP00000335121   ENSP00000322100  
     ENSP00000444899   ENSP00000387242   ENSP00000403257  

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    Uscn Proteins for ITM2C

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome ISS--
    GO:0005765lysosomal membrane IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA19114711
    GO:0016021integral to membrane IEA--


    ITM2C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ITM2C for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007084 BRICHOS_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQX7

    ProtoNet protein and cluster: Q9NQX7

    1 Blocks protein family: IPB007084 BRICHOS domain

    UniProtKB/Swiss-Prot: ITM2C_HUMAN, Q9NQX7
    Similarity: Belongs to the ITM2 family
    Similarity: Contains 1 BRICHOS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ITM2C_HUMAN, Q9NQX7
    Function: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its
    access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible,
    suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and
    neuronal differentiation (By similarity)

    miRNA
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    hsa-miR-4291 hsa-miR-4311 hsa-miR-1321 hsa-miR-539 hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-218-1*
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IPI19849849
    GO:0005515protein binding IPI18452648
    GO:0005524ATP binding IEA--


    ITM2C for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ITM2C:
     Decreased nuclei size in G2M 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITM2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ITM2C (Q9NQX72, 3 ENSP000003227304) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF7Q9UBF63, ENSP000002734804I2D: score=4 STRING: ENSP00000273480
    BACE1P568173, ENSP000003185854I2D: score=2 STRING: ENSP00000318585
    MTNR1BP492863, ENSP000002570684I2D: score=2 STRING: ENSP00000257068
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010977negative regulation of neuron projection development IDA18452648
    GO:0012502induction of programmed cell death IEA--
    GO:0030182neuron differentiation ISS--


    ITM2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITM2C
    Search CenterWatch for drugs/clinical trials and news about ITM2C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITM2C gene (3 alternative transcripts): 
    NM_001012514.1  NM_001012516.1  NM_030926.4  

    Unigene Cluster for ITM2C:

    Integral membrane protein 2C
    Hs.111577  [show with all ESTs]
    Unigene Representative Sequence: NM_030926
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457215 ENST00000541852 ENST00000326427(uc002vqz.3 uc002vra.3 uc002vrb.3)
    ENST00000335005(uc002vrc.3) ENST00000326407(uc002vrd.3) ENST00000543957
    ENST00000409704 ENST00000418408 ENST00000492029

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    hsa-miR-4291 hsa-miR-4311 hsa-miR-1321 hsa-miR-539 hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-218-1*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB003629.1 AF271781.1 AF272043.1 AK056321.1 AK075361.1 AK090975.1 AK222697.1 AK295503.1 
    AK303199.1 AK307702.1 AL136603.1 AL713651.1 AY049777.1 BC002424.1 BC025742.1 BC050668.1 
    BC098563.1 CR457208.1 D87062.1 

    24/33 DOTS entries (see all 33):

    DT.100679059  DT.100679057  DT.87017388  DT.100679055  DT.121003813  DT.100679056  DT.95121925  DT.92390033 
    DT.102835676  DT.97799430  DT.95323346  DT.100862614  DT.100865245  DT.100868461  DT.100868474  DT.121003826 
    DT.100870988  DT.121003780  DT.121003824  DT.121003834  DT.100676513  DT.100679067  DT.100683566  DT.100856823 

    24/676 AceView cDNA sequences (see all 676):

    BQ879617 BG912025 BQ017300 NM_030926 CN478648 AA593814 AI077778 BU631822 
    BF981426 BQ434277 BU740008 BM709442 CK904353 AF272043 BM749980 CF131614 
    CR598205 AK075361 AA907485 AY049777 AW051214 BG056353 AA985619 AA158691 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITM2C    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:              -                                             
    SP2:        -     -                                             
    SP3:              -           -                                 
    SP4:                          -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for ITM2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITM2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTACTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ITM2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITM2C

    SOURCE GeneReport for Unigene cluster: Hs.111577

    UniProtKB/Swiss-Prot: ITM2C_HUMAN, Q9NQX7
    Tissue specificity: High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus,
    thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITM2C gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ITM2C1 integral membrane protein 2C 70.88(n)
    68.97(a)
      424831  XM_422643.3  XP_422643.3 
    lizard
    (Anolis carolinensis)
    Reptilia ITM2C6
    --
    55(a)
    1 ↔ 1
    3(28254734-28260310)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI446652.12   -- 82.03(n)    BI446652.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj35c022 wufj35c02 75.6(n)   335863  BC054689.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36626
    --
    16(a)
    1 → many
    2L(821422-824337)
    worm
    (Caenorhabditis elegans)
    Secernentea C25F6.76
    Protein C25F6.7, isoform b
    15(a)
    1 → many
    X(5445037-5447998)


    ENSEMBL Gene Tree for ITM2C (if available)
    TreeFam Gene Tree for ITM2C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITM2C gene
    ITM2B2  ITM2A2  
    2 SIMAP similar genes for ITM2C using alignment to 5 protein entries:     ITM2C_HUMAN (see all proteins):
    ITM2B    ITM2A

    ITM2C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 NCBI SNPs in ITM2C are shown (see all 346    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871196321,2
    --231727762(+) TAGGAA/GTCACT 3 -- us2k10--------
    rs1438152081,2
    --231727789(+) CCAGCA/CCTTGG 3 -- us2k10--------
    rs29180091,2
    C,F,H,--231727806(+) TTGAGC/TCCATG 3 -- us2k124Minor allele frequency- T:0.19NS EA NA WA CSA 2353
    rs29180101,2
    C,F,--231727818(+) TCAAGG/CGTAAG 3 -- us2k113Minor allele frequency- C:0.20NA WA CSA EA 377
    rs1915529771,2
    --231728055(+) CTAATA/GTGTAG 3 -- us2k10--------
    rs1996190691,2
    C--231728074(+) GGCTGG/TGATGA 3 -- us2k10--------
    rs1458066041,2
    --231728087(+) ATTAAA/GTAATT 3 -- us2k10--------
    rs1836939141,2
    --231728139(+) GACCAC/TATCCT 3 -- us2k10--------
    rs1877509301,2
    --231728182(+) TTTCTA/GCCACA 3 -- us2k10--------
    rs1490149611,2
    --231728240(+) GTGAAA/GGAATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITM2C (231729354 - 231743963 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ITM2C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITM2C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ITM2C for disorders           About GeneDecksing

    OMIM gene information: 609554    OMIM disorders: --

    6 diseases for ITM2C:    About MalaCards
    cerebritis    anemia of prematurity    anemia    dementia
    influenza    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ITM2C (2 documents)

    Export disorders for ITM2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITM2C gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ITM2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. (PubMed id 19114711)1, 2 Martin L....Haass C. (2009)
    2. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. (PubMed id 19366692)1, 2 Matsuda S....D'Adamio L. (2009)
    3. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. (PubMed id 18452648)1, 2 Gong Y....Yuan J. (2008)
    4. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. (PubMed id 15606899)1, 2 Wickham L.... Seidah N.G. (2005)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Sequence, genomic structure and tissue expression of human BRI3, a member of the BRI gene family. (PubMed id 11290423)1, 2 Vidal R.... Frangione B. (2001)
    10. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 3 Mao M.... Chen Z. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81618 HGNC: 6175 AceView: ITM2C Ensembl:ENSG00000135916 euGenes: HUgn81618
    ECgene: ITM2C H-InvDB: ITM2C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITM2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITM2C gene:
    Search GeneIP for patents involving ITM2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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