V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ITM2B Gene

protein-coding GIFtS: 62

GC13P047705

integral membrane protein 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABRI ^², ⁵
BRI ^¹, ², ³, ⁵
BRI2 ^², ³
BRICD2B ^²
E25B ^¹, ²
E3-16 ^¹, ²
FBD ^², ⁵
OTTHUMP00000018394 ^²

Descriptions
BRICHOS domain containing 2B ^²
Transmembrane protein BRI ^³
integral membrane protein 2B ^²

External Ids
HGNC: 6174¹
Entrez Gene: 9445²
UniProtKB: Q9Y287³
Ensembl: ENSG00000136156⁷

Search outside databases for aliases for ITM2B gene

Previous GC identifers: GC13P046807 GC13P042794 GC13P047743 GC13P046605 GC13P046602

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ITM2B gene

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.2

ITM2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P047705: (about GC identifiers)

Start:	47,705,309 bp from pter
End:	47,734,228 bp from pter
Size:	28,920 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ITM2B_HUMAN, Q9Y287 (See protein sequence)

Recommended Name: Integral membrane protein 2B

Size: 266 amino acids; 30338 Da

Subunit: Interacts with SPPL2A and SPPL2B

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein

Secondary accessions: Q9NYH1

Post-translational modifications:

The C-terminal part of the ectodomain is processed by furin and related proteases producing a

secreted peptide of 4 to 5 kDa. For the FBD ABRI and FDD ADAN variants the C-terminal secreted

peptide is larger and may produce amyloid fibrils responsible for neuronal dysfunction and

dementia. The remaining part of the ectodomain containing the BRICHOS domain is cleaved by ADAM10

and is secreted as a peptide of 25 kDa. The membrane-bound N-terminal fragment (NTF) of 22 kDa is

further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis

producing a secreted peptide (BRI2C) and an intracellular domain (ICD) released in the cytosol¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_068839.1

ENSEMBL proteins:

ENSP00000367828 ENSP00000367811

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ITM2B)
	Human Recombinant Proteins from Abnova (ITM2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ITM2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ITM2B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ITM2B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ITM2B)
	Novus Biologicals Antibodies for ITM2B

Assays for ITM2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y287

ProtoNet protein and cluster: Q9Y287

1 Blocks protein family: IPB007084 BRICHOS domain

UniProtKB/Swiss-Prot: ITM2B_HUMAN, Q9Y287

Similarity: Belongs to the ITM2 family

Similarity: Contains 1 BRICHOS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITM2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITM2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021999

Applied Biosystems Silencer® siRNAs for ITM2B

Sigma-Aldrich siRNA and siRNA Panels for ITM2B

Sigma-Aldrich shRNA for ITM2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ITM2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021999
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021999
untagged cDNA clones in CMV expression vector (see all 2): NM_021999

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021999

Genatlas biochemistry entry for ITM2B:

integral membrane protein type 2B,ubiquitously expressed

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itm2b):

nervous system

no phenotypic analysis

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ITM2B

5/7 Interacting proteins for ITM2B (ENSP00000367828³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	ENSP00000284981³	STRING (score=.981)
CST3	ENSP00000366124³	STRING (score=.891)
FURIN	ENSP00000268171³	STRING (score=.809)
INS	ENSP00000370731³	STRING (score=.8)
PLAT	ENSP00000220809³	STRING (score=.746)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	TAS	10391242
GO:0007605	sensory perception of sound	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ITM2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITM2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITM2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021999

Sigma-Aldrich siRNA and siRNA Panels for ITM2B

Sigma-Aldrich shRNA for ITM2B

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for ITM2B gene:

NM_021999.4

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021999
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021999
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021999

Additional cDNA sequence:

AF086918.1 AF092128.1 AF136973.1 AF152462.1 AF246221.1 AK000503.1 AK027411.1 AK130048.1

BC000554.2 BC016148.1 BC018053.1 BT006863.1 BX537657.1 CR590893.1 CR592908.1 CR593958.1

CR594037.1 CR594079.1 CR594256.1 CR595747.1 CR598047.1 CR599660.1 CR599825.1 CR599884.1

CR603570.1 CR606888.1 CR608090.1 CR610320.1 CR610712.1 CR612400.1 CR613483.1 CR617212.1

CR618055.1 CR619102.1 CR620534.1 CR620837.1 CR621556.1 CR621906.1 CR625796.1 CR626358.1

24/38 DOTS entries (see all 38 ):

DT.453047 DT.92466883 DT.95180619 DT.92338432 DT.100890268 DT.100890301 DT.95174820 DT.100890275

DT.120786014 DT.100890304 DT.95197563 DT.100890290 DT.102835936 DT.120786093 DT.95345614 DT.100890302

DT.120786036 DT.95174823 DT.95174831 DT.100890305 DT.100890306 DT.120786076 DT.91984220 DT.92352650

24/1389 AceView cDNA sequences (see all 1389 ):

CD367541 AI624978 AI473615 CD518851 AI363736 CR608090 H43894 T31525

AW027859 CB119292 CD517634 T30142 AW167058 CB122895 H88747 AA630492

CR613483 CB121865 AI912364 CR612400 CA395865 BP381737 AI025980 CD367861

highest scoring ESTs for ITM2B:

AI499172 AI638576 AA046071 AA135881 AA327418 AA384702 AA586771 AA746260 AA843944 AA852819

Unigene Cluster for ITM2B:

Integral membrane protein 2B

Hs.643683 [show with all ESTs]

Unigene Representative Sequence: BX537657

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ITM2B

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7
SP1:					-
SP2:
SP3:					-				-		-

About this scheme

ECgene alternative splicing isoforms for ITM2B

2 Ensembl transcripts including schematic representations:

ENST00000378565 ENST00000378549

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ITM2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ITM2B

¹ / ² / ³

9 probe-sets matching ITM2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73196_s_at²^{, 3}	U95-E	1	1.00	1.00	0.92	1.38	AI283537	0.60	1.00	0.82	1
51682_s_at²^{, 3}	U95-C	1	1.00	1.00	0.95	1.36	AA007156	0.60	1.00	0.82	1
41300_s_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.00	AA477898	0.40	1.00	0.76	1
48830_r_at²^{, 3}	U95-C	1	1.00	1.00	0.61	0.49	AI499172	1.00	1.00	1.00	1
44784_at²^{, 3}	U95-B	1	0.50	1.00	0.83	0.77	AI638576	1.00	1.00	1.00	1
217732_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF092128	0.80	1.00	0.91	1
217731_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021999	0.60	1.00	0.82	1
217732_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217731_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAGTAGCAA

SOURCE GeneReport for Unigene cluster: Hs.643683
Expression variation in blood from EXPOLDB for ITM2B
UniProtKB/Swiss-Prot: ITM2B_HUMAN, Q9Y287
Tissue specificity: Expressed in brain and in other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ITM2B gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ITM2B¹	--	integral membrane protein 2B	92.04(n) 96.02(a)	476916 XM_534119.2 XP_534119.2
chimpanzee (Pan troglodytes)	ITM2B¹	--	integral membrane protein 2B	99.25(n) 98.87(a)	452714 XM_509776.2 XP_509776.2
cow (Bos taurus)	ITM2B¹	--	integral membrane protein 2B	90.57(n) 94.72(a)	510575 NM_001035093.1 NP_001030265.1
rat (Rattus norvegicus)	Itm2b¹	--	integral membrane protein 2B	88.22(n) 96.24(a)	290364 NM_001006963.1 NP_001006964.1
mouse (Mus musculus)	Itm2b^{1, 5}	14 (32.50 cM)⁵	integral membrane protein 2B^{1, 5}	86.09(n)¹ 95.49(a)¹	16432¹ NM_008410.2¹ NP_032436.1¹ AB030203⁵ AB030204⁵ (see all 58)

About this table Species with no ortholog for ITM2B

ENSEMBL Gene Tree for ITM2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ITM2B gene

ITM2A² ITM2C²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/191 NCBI SNPs in ITM2B are shown (see all 191 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 75)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3809328^1,2	A,C,F,H	47704511(-)	`CGTTAC/TTGCGT`	1	--	ng5¹		19	NS MN EA EU WA NA	2208
	rs9332305^1,2	C,F,H	47733586(+)	`TCATAG/AATAAT`	1	--	ut3¹		8	NS EU EA WA NA	722
--	rs12100135^1,2	A,C,F	47705005(+)	`TACAGG/AGAAGC`	1	--	ng5¹		2	MN EA	356
	rs9332304^1,2	C,F,H	47733504(+)	`AATTCA/TATTAA`	1	--	ut3¹		8	NS EU EA WA NA	710
	rs7332376^1,2	A,H	47703650(+)	`TTTTGT/CCAACC`	1	--	ng5¹		3	EU EA	298
	rs9332306^1,2	F,H	47733646(+)	`TTTATC/TTGGAT`	1	--	ut3¹ ese³		5	NS EU EA WA	588
--	rs9332246^1,2	F	47704215(+)	`CAGCCC/TAGGAT`	1	--	ng5¹		1	NS	162
--	rs9332248^1,2	F	47704774(+)	`TGGGAC/GTAGGC`	1	--	ng5¹		1	NS	168
	rs9534999^1,2	H	47734063(+)	`TTCTTC/AAAATC`	1	--	ut3¹		4	EU EA WA	420
--	rs17071497^1,2	F	47704728(+)	`AGATGT/CTTGAA`	1	--	ng5¹		4	MN EA	712

About this table

HapMap Linkage Disequilibrium images for ITM2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603904 disorders: 176500 117300

UniProtKB/Swiss-Prot: ITM2B_HUMAN, Q9Y287

Defects in ITM2B may be associated with familial British dementia (FBD) [MIM:176500]. FBD

is an autosomal dominant disease characterized by progressive dementia, spasticity, and cerebellar

ataxia, with onset at around the fifth decade of life. Cerebral amyloid angiopathy, non-neuritic

and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions

Defects in ITM2B may be associated with familial Danish dementia (FDD) [MIM:117300]; also

known as heredopathia ophthalmo-oto-encephalica. FDD is an autosomal dominant disorder

characterized by cataracts, deafness, progressive ataxia, and dementia. Neuropathological findings

include severe widespread cerebral amyloid angiopathy, hippocampal plaques, and neurofibrillary

tangles, similar to Alzheimer disease

9 Novoseek disease relationships for ITM2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dementia, familial british	99.06	11	14586629 (2), 18282158 (2), 10526337 (1), 12883829 (1) (see all 9)
dementia, familial danish	99.01	7	15182222 (1), 17029605 (1), 12566161 (1), 18477478 (1) (see all 7)
cerebral amyloid angiopathy	89.29	3	15152461 (1), 11159188 (1), 18282158 (1)
familial dementia	81.72	2	16246057 (1), 15983050 (1)
dementia	71.05	18	16612984 (2), 11290423 (2), 12196136 (1), 16141213 (1) (see all 12)
neurodegenerative diseases	67.29	7	10526337 (1), 16027166 (1), 17029605 (1), 12566161 (1) (see all 7)
alzheimers disease	66.81	4	14586629 (1), 11290423 (1), 18282158 (1)
neurodegeneration	66.60	4	16246057 (1), 11290423 (1)
senile plaques	66.11	2	14586629 (1), 11159188 (1)

About this table

1 PharmGKB disease relationship for ITM2B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

About this table

Human Gene Mutation Database: ITM2B

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/51 PubMed articles for ITM2B gene (see all 51 ):

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)^{1, 3, 4} Martin L....Haass C. (2008)
A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. (PubMed id 10781099)^{1, 3, 4} Vidal R.... Frangione B. (2000)
A stop-codon mutation in the BRI gene associated with familial British dementia. (PubMed id 10391242)^{1, 3, 4} Vidal R....Ghiso J. (1999)
cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B. (PubMed id 9795190)^{1, 2, 3} Pittois K....Merregaert J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{3, 4} Hu R.-M.... Chen J.-L. (2000)
Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. (PubMed id 14586629)^{1, 3} Akiyama H....McGeer P.L. (2004)
Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease. (PubMed id 18282158)^{1, 3} Lashley T....Holton J.L. (2008)
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. (PubMed id 16027166)^{1, 3} Fotinopoulou A....Efthimiopoulos S. (2005)
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. (PubMed id 15983050)^{1, 3} Matsuda S....D'Adamio L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9445	HGNC: 6174	AceView: ITM2B	Ensembl:ENSG00000136156	euGenes: HUgn9445
ECgene: ITM2B	H-InvDB: ITM2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ITM2B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/itm2b/

Licensable Technologies for ITM2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ITM2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ITM2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ITM2B		Antibodies for ITM2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ITM2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ITM2B)
	Antibodies (ITM2B)
	Chimera RNAi (ITM2B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ITM2B)
	Antibodies (ITM2B)

Search OriGene for ITM2B

Search Tocris compounds for ITM2B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ITM2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ITM2B Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ITM2B Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ITM2B

Summaries
for ITM2B

Genomic Location
for ITM2B

Proteins
for ITM2B

Protein Domains/
Families
for ITM2B

Gene Function
for ITM2B

Pathways & Interactions
for ITM2B

Drugs & Compounds
for ITM2B

Transcripts
for ITM2B

Expression
for ITM2B

Orthologs
for ITM2B

Paralogs
for ITM2B

SNPs/Variants
for ITM2B

Disorders & Mutations
for ITM2B

Medical News
for ITM2B

Publications
for ITM2B

Search for ITM2B

Genome Databases showing ITM2B

Other Databases showing ITM2B

Specialized Databases showing ITM2B

Licensable Technologies
for ITM2B

Services
for ITM2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ITM2B Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ITM2B

Summariesfor ITM2B

Genomic Locationfor ITM2B

Proteinsfor ITM2B

Protein Domains/Familiesfor ITM2B

Gene Functionfor ITM2B

Pathways & Interactionsfor ITM2B

Drugs & Compoundsfor ITM2B

Transcriptsfor ITM2B

Expression for ITM2B

Orthologsfor ITM2B

Paralogsfor ITM2B

SNPs/Variantsfor ITM2B

Disorders & Mutationsfor ITM2B

Medical Newsfor ITM2B

Publicationsfor ITM2B

Search for ITM2B

Genome Databases showing ITM2B

Other Databases showing ITM2B

Specialized Databases showing ITM2B

Licensable Technologiesfor ITM2B

Servicesfor ITM2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ITM2B

Summaries
for ITM2B

Genomic Location
for ITM2B

Proteins
for ITM2B

Protein Domains/
Families
for ITM2B

Gene Function
for ITM2B

Pathways & Interactions
for ITM2B

Drugs & Compounds
for ITM2B

Transcripts
for ITM2B

Expression
for ITM2B

Orthologs
for ITM2B

Paralogs
for ITM2B

SNPs/Variants
for ITM2B

Disorders & Mutations
for ITM2B

Medical News
for ITM2B

Publications
for ITM2B

Licensable Technologies
for ITM2B

Services
for ITM2B