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Aliases for ITLN2 Gene

Aliases for ITLN2 Gene

  • Intelectin 2 2 3 5
  • Endothelial Lectin HL-2 3 4
  • Intelectin-2 3
  • HL-2 3
  • HL2 3

External Ids for ITLN2 Gene

Previous GeneCards Identifiers for ITLN2 Gene

  • GC01M157692
  • GC01M158131
  • GC01M157727
  • GC01M159181
  • GC01M132271

Summaries for ITLN2 Gene

GeneCards Summary for ITLN2 Gene

ITLN2 (Intelectin 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN1.

UniProtKB/Swiss-Prot for ITLN2 Gene

  • May play a role in the defense system against pathogens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN2 Gene

Genomics for ITLN2 Gene

Regulatory Elements for ITLN2 Gene

Enhancers for ITLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F160986 0.2 ENCODE 13 -30.0 -29991 1.4 POU5F1 F11R ITLN2 ENSG00000232879 TSTD1 SLAMF7 KLHDC9 ITLN1 ARHGAP30 LOC105371471 NECTIN4
GH01F160946 0.6 Ensembl ENCODE 5.7 +9.1 9079 3.0 ARNT GATA2 NCOA1 PPARG CREB3 MEF2D SMARCA4 HMBOX1 KDM1A WT1 DUSP12 ITLN1 LY9 SLAMF7 ENSG00000228863 LOC101928372 ENSG00000232188 CD244 ITLN2 ENSG00000233691
GH01F160954 0.8 Ensembl ENCODE 0.8 +3.0 2978 0.4 ELF3 CTCF STAT1 ESRRA NR2F1 TRIM22 REST RAD21 KLF16 ZNF143 ITLN2 ENSG00000233691
GH01F160951 1 Ensembl ENCODE 0.4 +5.5 5470 1.8 CTCF ZNF654 MAX TRIM22 REST ZNF48 RAD21 GATA3 JUND ZNF585B DUSP12 RPSAP18 ITLN1 LY9 SLAMF7 ENSG00000228863 ENSG00000232188 LOC101928372 ITLN2 ENSG00000233691
GH01F160971 1.1 ENCODE 0.4 -14.6 -14608 0.2 PKNOX1 MAZ TBL1XR1 MTA2 TBX21 EP300 RFX5 SP1 ZBTB48 IKZF1 TSTD1 F11R ITLN2 GC01M160999 PIR56289
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ITLN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITLN2 Gene

Chromosome:
1
Start:
160,945,020 bp from pter
End:
160,957,378 bp from pter
Size:
12,359 bases
Orientation:
Minus strand

Genomic View for ITLN2 Gene

Genes around ITLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN2 Gene

Proteins for ITLN2 Gene

  • Protein details for ITLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWU7-ITLN2_HUMAN
    Recommended name:
    Intelectin-2
    Protein Accession:
    Q8WWU7
    Secondary Accessions:
    • Q17RR2
    • Q5VYI0

    Protein attributes for ITLN2 Gene

    Size:
    325 amino acids
    Molecular mass:
    36212 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITLN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITLN2 Gene

Post-translational modifications for ITLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ITLN2

No data available for DME Specific Peptides for ITLN2 Gene

Domains & Families for ITLN2 Gene

Gene Families for ITLN2 Gene

Protein Domains for ITLN2 Gene

Suggested Antigen Peptide Sequences for ITLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWU7

UniProtKB/Swiss-Prot:

ITLN2_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ITLN2: view

Function for ITLN2 Gene

Molecular function for ITLN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the defense system against pathogens.

Gene Ontology (GO) - Molecular Function for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ITLN2: view

Phenotypes for ITLN2 Gene

GenomeRNAi human phenotypes for ITLN2:
genes like me logo Genes that share phenotypes with ITLN2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ITLN2 Gene

Localization for ITLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITLN2 Gene COMPARTMENTS Subcellular localization image for ITLN2 gene
Compartment Confidence
extracellular 5
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ITLN2: view

Pathways & Interactions for ITLN2 Gene

SuperPathways for ITLN2 Gene

No Data Available

Interacting Proteins for ITLN2 Gene

Selected Interacting proteins: Q8WWU7-ITLN2_HUMAN for ITLN2 Gene via IID

Gene Ontology (GO) - Biological Process for ITLN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ITLN2 Gene

Transcripts for ITLN2 Gene

mRNA/cDNA for ITLN2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITLN2 Gene

Intelectin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN2 Gene

No ASD Table

Relevant External Links for ITLN2 Gene

GeneLoc Exon Structure for
ITLN2
ECgene alternative splicing isoforms for
ITLN2

Expression for ITLN2 Gene

mRNA expression in normal human tissues for ITLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITLN2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x40.2) and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for ITLN2 Gene

This gene is overexpressed in Pancreatic juice (62.8) and Spinal cord (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITLN2 Gene



Protein tissue co-expression partners for ITLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITLN2 Gene:

ITLN2

SOURCE GeneReport for Unigene cluster for ITLN2 Gene:

Hs.385631

mRNA Expression by UniProt/SwissProt for ITLN2 Gene:

Q8WWU7-ITLN2_HUMAN
Tissue specificity: Expressed only in the small intestine.
genes like me logo Genes that share expression patterns with ITLN2: view

Primer Products

Orthologs for ITLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITLN2 34 35
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia LOC100300695 34
  • 83.23 (n)
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
ITLN2 35 35
  • 80 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
ManyToMany
-- 35
  • 74 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145536 34
  • 65.58 (n)
MGC76330 34
African clawed frog
(Xenopus laevis)
Amphibia XEEL 34
zebrafish
(Danio rerio)
Actinopterygii BX571811.1 35
  • 57 (a)
ManyToMany
BX927082.1 35
  • 55 (a)
ManyToMany
itln2 35 35
  • 54 (a)
ManyToMany
zgc:153219 35
  • 54 (a)
ManyToMany
ITLN4 35
  • 51 (a)
ManyToMany
BX571811.2 35
  • 50 (a)
ManyToMany
itln3 35
  • 49 (a)
ManyToMany
itln1 35
  • 45 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
Species where no ortholog for ITLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN2 Gene

ENSEMBL:
Gene Tree for ITLN2 (if available)
TreeFam:
Gene Tree for ITLN2 (if available)

Paralogs for ITLN2 Gene

Paralogs for ITLN2 Gene

(1) SIMAP similar genes for ITLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITLN2: view

Variants for ITLN2 Gene

Sequence variations from dbSNP and Humsavar for ITLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10543673 -- 160,956,690(+) AAAAC(-/TCTTT)TCTTT intron-variant, upstream-variant-2KB
rs10595590 -- 160,956,698(+) TTTCT(-/TTTCT)GTAGA intron-variant, upstream-variant-2KB
rs10908815 -- 160,946,688(+) agcct(G/T)ggtga intron-variant
rs111311398 -- 160,949,065(+) AGTGG(A/G)GAGAG intron-variant, nc-transcript-variant
rs111451521 -- 160,956,621(+) ATCAC(A/G)CCATT intron-variant, upstream-variant-2KB

Variation tolerance for ITLN2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ITLN2 Gene

Disorders for ITLN2 Gene

Relevant External Links for ITLN2

Genetic Association Database (GAD)
ITLN2
Human Genome Epidemiology (HuGE) Navigator
ITLN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITLN2

No disorders were found for ITLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITLN2 Gene

Publications for ITLN2 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee J.K. … Pierce M. (Glycobiology 2001) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski K.A. … Florez J.C. (Diabetes 2010) 3 46 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ITLN2 Gene

Sources for ITLN2 Gene

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