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Aliases for ITLN2 Gene

Aliases for ITLN2 Gene

  • Intelectin 2 2 3
  • Endothelial Lectin HL-2 3 4
  • HL2 3 6
  • Intelectin-2 3
  • HL-2 3

External Ids for ITLN2 Gene

Summaries for ITLN2 Gene

GeneCards Summary for ITLN2 Gene

ITLN2 (Intelectin 2) is a Protein Coding gene. An important paralog of this gene is ITLN1.

UniProtKB/Swiss-Prot for ITLN2 Gene

  • May play a role in the defense system against pathogens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN2 Gene

Genomics for ITLN2 Gene

Genomic Location for ITLN2 Gene

Start:
160,945,020 bp from pter
End:
160,954,799 bp from pter
Size:
9,780 bases
Orientation:
Minus strand

Genomic View for ITLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN2 Gene

Regulatory Elements for ITLN2 Gene

Proteins for ITLN2 Gene

  • Protein details for ITLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWU7-ITLN2_HUMAN
    Recommended name:
    Intelectin-2
    Protein Accession:
    Q8WWU7
    Secondary Accessions:
    • Q17RR2
    • Q5VYI0

    Protein attributes for ITLN2 Gene

    Size:
    325 amino acids
    Molecular mass:
    36212 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITLN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITLN2 Gene

Proteomics data for ITLN2 Gene at MOPED

Post-translational modifications for ITLN2 Gene

No Post-translational modifications

Other Protein References for ITLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITLN2 Gene

Domains for ITLN2 Gene

Gene Families for ITLN2 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Protein Domains for ITLN2 Gene

UniProtKB/Swiss-Prot:

ITLN2_HUMAN
Domain:
  • Contains 1 fibrinogen C-terminal domain.:
    • Q8WWU7
genes like me logo Genes that share domains with ITLN2: view

Function for ITLN2 Gene

Molecular function for ITLN2 Gene

UniProtKB/Swiss-Prot Function: May play a role in the defense system against pathogens.

Gene Ontology (GO) - Molecular Function for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ITLN2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITLN2 Gene

Localization for ITLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITLN2 Gene COMPARTMENTS Subcellular localization image for ITLN2 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ITLN2: view

Pathways for ITLN2 Gene

SuperPathways for ITLN2 Gene

No Data Available

Interacting Proteins for ITLN2 Gene

Selected Interacting proteins: Q8WWU7-ITLN2_HUMAN for ITLN2 Gene via I2D

Symbol External ID(s) Details
EGFR

Gene Ontology (GO) - Biological Process for ITLN2 Gene

None

No data available for Pathways by source for ITLN2 Gene

Transcripts for ITLN2 Gene

mRNA/cDNA for ITLN2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITLN2 Gene

Intelectin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN2 Gene

No ASD Table

Relevant External Links for ITLN2 Gene

GeneLoc Exon Structure for
ITLN2
ECgene alternative splicing isoforms for
ITLN2

Expression for ITLN2 Gene

mRNA expression in normal human tissues for ITLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITLN2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (40.2) and Lung (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ITLN2 Gene

SOURCE GeneReport for Unigene cluster for ITLN2 Gene Hs.385631

mRNA Expression by UniProt/SwissProt for ITLN2 Gene

Q8WWU7-ITLN2_HUMAN
Tissue specificity: Expressed only in the small intestine.
genes like me logo Genes that share expressions with ITLN2: view

Orthologs for ITLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITLN2 36
  • 98.97 (n)
  • 98.77 (a)
ITLN2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 81 (a)
ManyToMany
-- 37
  • 81 (a)
ManyToMany
ITLN2 37
  • 80 (a)
ManyToMany
ITLN2 37
  • 79 (a)
ManyToMany
LOC100300695 36
  • 83.23 (n)
  • 82.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia XEEL 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145536 36
  • 65.58 (n)
  • 65.82 (a)
MGC76330 36
zebrafish
(Danio rerio)
Actinopterygii BX571811.1 37
  • 57 (a)
ManyToMany
BX571811.2 37
  • 50 (a)
ManyToMany
BX927082.1 37
  • 55 (a)
ManyToMany
itln1 37
  • 45 (a)
ManyToMany
itln2 37
  • 54 (a)
ManyToMany
itln2 37
  • 48 (a)
ManyToMany
itln3 37
  • 49 (a)
ManyToMany
ITLN4 37
  • 51 (a)
ManyToMany
zgc:153219 37
  • 54 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 12 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 15 (a)
ManyToMany
-- 37
  • 15 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
Species with no ortholog for ITLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN2 Gene

ENSEMBL:
Gene Tree for ITLN2 (if available)
TreeFam:
Gene Tree for ITLN2 (if available)

Paralogs for ITLN2 Gene

Paralogs for ITLN2 Gene

Selected SIMAP similar genes for ITLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITLN2: view

Variants for ITLN2 Gene

Sequence variations from dbSNP and Humsavar for ITLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs790059 -- 160,951,023(+) CAAGT(A/G)GGAGA intron-variant
rs790060 -- 160,951,418(+) GAAGA(C/T)GATGC intron-variant, utr-variant-5-prime
rs790061 -- 160,951,428(+) ctcca(C/T)gcatc intron-variant, utr-variant-5-prime
rs790062 -- 160,952,959(+) TAGAC(A/G)CCGGA intron-variant, upstream-variant-2KB
rs2252389 -- 160,952,405(-) GGTGA(C/T)GCTTA intron-variant, upstream-variant-2KB

Relevant External Links for ITLN2 Gene

HapMap Linkage Disequilibrium report
ITLN2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ITLN2 Gene

Disorders for ITLN2 Gene

Relevant External Links for ITLN2

Genetic Association Database (GAD)
ITLN2
Human Genome Epidemiology (HuGE) Navigator
ITLN2
genes like me logo Genes that share disorders with ITLN2: view

No data available for UniProtKB/Swiss-Prot for ITLN2 Gene

Publications for ITLN2 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee J.K. … Pierce M. (Glycobiology 2001) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski K.A. … Florez J.C. (Diabetes 2010) 3 49
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ITLN2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ITLN2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ITLN2
    • Block miRNA regulation of ITLN2 using miScript Target Protectors

    Sources for ITLN2 Gene

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