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Aliases for ITLN2 Gene

Aliases for ITLN2 Gene

  • Intelectin 2 2 3 5
  • Endothelial Lectin HL-2 3 4
  • HL-2 3
  • HL2 3

External Ids for ITLN2 Gene

Previous GeneCards Identifiers for ITLN2 Gene

  • GC01M157692
  • GC01M158131
  • GC01M157727
  • GC01M159181
  • GC01M132271

Summaries for ITLN2 Gene

GeneCards Summary for ITLN2 Gene

ITLN2 (Intelectin 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN1.

UniProtKB/Swiss-Prot for ITLN2 Gene

  • May play a role in the defense system against pathogens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN2 Gene

Genomics for ITLN2 Gene

Regulatory Elements for ITLN2 Gene

Enhancers for ITLN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITLN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITLN2 Gene

160,945,020 bp from pter
160,957,378 bp from pter
12,359 bases
Minus strand

Genomic View for ITLN2 Gene

Genes around ITLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN2 Gene

Proteins for ITLN2 Gene

  • Protein details for ITLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q17RR2
    • Q5VYI0

    Protein attributes for ITLN2 Gene

    325 amino acids
    Molecular mass:
    36212 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITLN2 Gene


neXtProt entry for ITLN2 Gene

Proteomics data for ITLN2 Gene at MOPED

Post-translational modifications for ITLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ITLN2

No data available for DME Specific Peptides for ITLN2 Gene

Domains & Families for ITLN2 Gene

Gene Families for ITLN2 Gene

Protein Domains for ITLN2 Gene

Suggested Antigen Peptide Sequences for ITLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibrinogen C-terminal domain.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ITLN2: view

Function for ITLN2 Gene

Molecular function for ITLN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the defense system against pathogens.

Phenotypes for ITLN2 Gene

GenomeRNAi human phenotypes for ITLN2:
genes like me logo Genes that share phenotypes with ITLN2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ITLN2 Gene

Localization for ITLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN2 Gene


Subcellular locations from

Jensen Localization Image for ITLN2 Gene COMPARTMENTS Subcellular localization image for ITLN2 gene
Compartment Confidence
extracellular 5
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ITLN2 Gene

Pathways & Interactions for ITLN2 Gene

SuperPathways for ITLN2 Gene

No Data Available

Interacting Proteins for ITLN2 Gene

Selected Interacting proteins: Q8WWU7-ITLN2_HUMAN for ITLN2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ITLN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITLN2 Gene

Drugs & Compounds for ITLN2 Gene

No Compound Related Data Available

Transcripts for ITLN2 Gene

mRNA/cDNA for ITLN2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITLN2 Gene

Intelectin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN2 Gene

No ASD Table

Relevant External Links for ITLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITLN2 Gene

mRNA expression in normal human tissues for ITLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITLN2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x40.2) and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for ITLN2 Gene

This gene is overexpressed in Pancreatic juice (62.8) and Spinal cord (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITLN2 Gene

SOURCE GeneReport for Unigene cluster for ITLN2 Gene Hs.385631

mRNA Expression by UniProt/SwissProt for ITLN2 Gene

Tissue specificity: Expressed only in the small intestine.
genes like me logo Genes that share expression patterns with ITLN2: view

Protein tissue co-expression partners for ITLN2 Gene

Primer Products

Orthologs for ITLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100300695 35
  • 83.23 (n)
  • 82.59 (a)
-- 36
  • 81 (a)
-- 36
  • 81 (a)
ITLN2 36
  • 80 (a)
ITLN2 36
  • 79 (a)
(Pan troglodytes)
Mammalia ITLN2 35
  • 98.97 (n)
  • 98.77 (a)
ITLN2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
-- 36
  • 74 (a)
-- 36
  • 79 (a)
-- 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145536 35
  • 65.58 (n)
  • 65.82 (a)
MGC76330 35
African clawed frog
(Xenopus laevis)
Amphibia XEEL 35
(Danio rerio)
Actinopterygii BX571811.1 36
  • 57 (a)
BX571811.2 36
  • 50 (a)
BX927082.1 36
  • 55 (a)
itln1 36
  • 45 (a)
itln2 36
  • 54 (a)
itln2 36
  • 48 (a)
itln3 36
  • 49 (a)
ITLN4 36
  • 51 (a)
zgc:153219 36
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
-- 36
  • 21 (a)
-- 36
  • 23 (a)
-- 36
  • 15 (a)
-- 36
  • 15 (a)
-- 36
  • 25 (a)
-- 36
  • 44 (a)
Species with no ortholog for ITLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN2 Gene

Gene Tree for ITLN2 (if available)
Gene Tree for ITLN2 (if available)

Paralogs for ITLN2 Gene

Paralogs for ITLN2 Gene

(1) SIMAP similar genes for ITLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITLN2: view

Variants for ITLN2 Gene

Sequence variations from dbSNP and Humsavar for ITLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6680969 - 160,951,176(+) TCCCA(C/G/T)GCATG reference, missense
rs12090411 - 160,950,641(+) AATGC(C/T)GCATG reference, missense
rs790059 -- 160,951,023(+) CAAGT(A/G)GGAGA intron-variant
rs790060 -- 160,951,418(+) GAAGA(C/T)GATGC intron-variant
rs790061 -- 160,951,428(+) ctcca(C/T)gcatc intron-variant

Variation tolerance for ITLN2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ITLN2 Gene

Disorders for ITLN2 Gene

Relevant External Links for ITLN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITLN2 Gene

Publications for ITLN2 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee J.K. … Pierce M. (Glycobiology 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution. (PMID: 23643964) Yan J. … Feng L. (Dev. Comp. Immunol. 2013) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski K.A. … Florez J.C. (Diabetes 2010) 3

Products for ITLN2 Gene

Sources for ITLN2 Gene