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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITLN2 Gene

protein-coding   GIFtS: 44
GCID: GC01M160914

intelectin 2
  Search for ITLN2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITLN2    

Aliases
for ITLN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Intelectin 21 2
HL-21 2
Endothelial Lectin HL-22 3
HL22 5
Intelectin-21

External Ids:    HGNC: 205991   Entrez Gene: 1426832   Ensembl: ENSG000001587647   OMIM: 6098745   UniProtKB: Q8WWU73   

Export aliases for ITLN2 gene to outside databases

Previous GC identifers: GC01M157692 GC01M158131 GC01M157727 GC01M159181 GC01M132271


Summaries
for ITLN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
Function: May play a role in the defense system against pathogens (By similarity)




Genomic Views
for ITLN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITLN2 gene promoter:
         AhR   USF1   Pax-5   LUN-1   C/EBPalpha   Arnt   YY1   Gfi-1   CHOP-10   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITLN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23.5

ITLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITLN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160914:  view genomic region     (about GC identifiers)

Start:
 160,914,815 bp from pter      End:
 160,924,589 bp from pter
Size:
 9,775 bases      Orientation:
 minus strand

Proteins
for ITLN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7 (See protein sequence)
Recommended Name: Intelectin-2 precursor  
Size: 325 amino acids; 36212 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5VYI0

Explore the universe of human proteins at neXtProt for ITLN2: NX_Q8WWU7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWU7

    • ITLN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_543154.1  
    ENSEMBL proteins: 
     ENSP00000357008  

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    Uscn Proteins for ITLN2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    ITLN2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ITLN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITLN2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q8WWU7

    ProtoNet protein and cluster: Q8WWU7

    UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ITLN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
    Function: May play a role in the defense system against pathogens (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0030246carbohydrate binding ----


    ITLN2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ITLN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITLN2

    1 Interacting protein for ITLN2 (Q8WWU73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005333I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--


    ITLN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITLN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITLN2
    Search CenterWatch for drugs/clinical trials and news about ITLN2 

    Transcripts
    for ITLN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for ITLN2 gene: 
    NM_080878.2  

    Unigene Cluster for ITLN2:

    Intelectin 2
    Hs.385631  [show with all ESTs]
    Unigene Representative Sequence: AY358905
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368029(uc001fxd.3 uc009wts.3 uc010pju.2) ENST00000494442
    ENST00000490489

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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AY065973.1 AY358905.1 BC117225.1 BC143339.1 BC143341.1 

    1 DOTS entry:

    DT.97838744 

    12 AceView cDNA sequences:

    BM993101 AY358905 AY065973 BE045344 NM_080878 BX505934 BG482966 BM998678 
    BI821675 BF515308 BM993198 BE327604 

    GeneLoc Exon Structure


    Expression
    for ITLN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGCATTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITLN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ITLN2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.385631

    UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
    Tissue specificity: Expressed only in the small intestine

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN2

    Orthologs
    for ITLN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ITLN2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 66(a)
    		 1 → many
    		 GL343929.1(67124-79262)
    African clawed frog
    (Xenopus laevis)    		 Amphibia XEEL2 embryonic epidermal lectin 74.54(n)    AB105372.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5649581 intelectin-1-like 62.68(n)
    61.96(a)    		   564958  XM_688277.1  XP_693369.1 
            Species with no ortholog for ITLN2

    ENSEMBL Gene Tree for ITLN2 (if available)
    TreeFam Gene Tree for ITLN2 (if available) 

    Paralogs
    for ITLN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITLN2 gene
    ITLN12  
    1 SIMAP similar gene for ITLN2 using alignment to 3 protein entries:     ITLN2_HUMAN (see all proteins):
    ITLN1

    ITLN2 for paralogs           About GeneDecksing



    Genomic Variants
    for ITLN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 NCBI SNPs in ITLN2 are shown (see all 287)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs22434701,2
    		C,--160914332(+) GGAGTG/ACAATG 1 -- ds50019Minor allele frequency- A:0.02NA WA CSA EA 369
    rs1401940151,2
    		--160914366(+) CTCTGC/TCTCCC 1 -- ds50010--------
    rs618021661,2
    		C,F,--160914529(+) GCCTCG/AGCCTC 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs730120911,2
    		C,F,--160914606(+) TTTTTT/AATATC 1 -- ds50013Minor allele frequency- A:0.09WA CSA 122
    rs1838398021,2
    		C,--160914885(+) TAGCCA/GGGGTT 1 -- ut310--------
    rs2002571251,2
    		--160914905(+) GTTCTC/TGCCCT 1 -- ut310--------
    rs67019201,2
    		C,F,H,--160914917(+) ACACCG/ACAGAG 1 -- ut31 ese312Minor allele frequency- A:0.03NS EA NA WA EU 2625
    rs1869343621,2
    		C,--160914955(+) CAGCCA/GCCTCC 2 A V mis10--------
    rs1499289061,2
    		C,F,--160915019(+) AAAGGC/TGGAGA 2 T A mis12Minor allele frequency- T:0.00NA EU 5873
    rs1836528831,2
    		C,--160915037(+) ACACTA/GACGGG 2 Q * stg10--------

    HapMap Linkage Disequilibrium report for ITLN2 (160914815 - 160924589 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ITLN2: --

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    DNA2.0 Custom Variant and Variant Library Synthesis for ITLN2

    Disorders / Diseases
    for ITLN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITLN2 for disorders           About MalaCards

    ITLN2 for disorders           About GeneDecksing

    OMIM gene information: 609874    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: ITLN2 (4 documents)

    Export disorders for ITLN2 gene to outside databases

    Publications
    for ITLN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITLN2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ITLN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PubMed id 11181563)1, 2, 3 Lee J.K....Pierce M. (2001)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Common variants in 40 genes assessed for diabetes inc idence and response to metformin and lifestyle intervention in the diabetes pre vention program. (PubMed id 20682687)1 Jablonski K.A....Florez J.C. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    5. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. (PubMed id 17983620)9 French A.T....Pemberton A.D. (2008)
    10. Developmental expression of XEEL, a novel molecule of the Xenopus oocyte cortical granule lectin family. (PubMed id 12802587)9 Nagata S....Fujita N. (2003)

    External Searches for ITLN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITLN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 142683 HGNC: 20599 AceView: ITLN2 Ensembl:ENSG00000158764 euGenes: HUgn142683
    ECgene: ITLN2 H-InvDB: ITLN2

    Other Databases showing ITLN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITLN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITLN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ITLN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITLN2 gene:
    Search GeneIP for patents involving ITLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ITLN2 gene

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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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