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ITLN2 Gene

protein-coding   GIFtS: 46
GCID: GC01M160914

Intelectin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intelectin 21 2
Endothelial Lectin HL-22 3
HL22 5
HL-22
intelectin-22

External Ids:    HGNC: 205991   Entrez Gene: 1426832   Ensembl: ENSG000001587647   OMIM: 6098745   UniProtKB: Q8WWU73   

Export aliases for ITLN2 gene to outside databases

Previous GC identifers: GC01M157692 GC01M158131 GC01M157727 GC01M159181 GC01M132271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ITLN2 Gene:
ITLN2 (intelectin 2) is a protein-coding gene. An important paralog of this gene is ITLN1.

UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
Function: May play a role in the defense system against pathogens (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITLN2 gene promoter:
         AhR   USF1   Pax-5   LUN-1   C/EBPalpha   Arnt   YY1   Gfi-1   CHOP-10   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITLN2 promoter sequence
   Search Chromatin IP Primers for ITLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23.5

ITLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITLN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160914:  view genomic region     (about GC identifiers)

Start:
160,914,815 bp from pter      End:
160,924,589 bp from pter
Size:
9,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7 (See protein sequence)
Recommended Name: Intelectin-2 precursor  
Size: 325 amino acids; 36212 Da
Secondary accessions: Q5VYI0

Explore the universe of human proteins at neXtProt for ITLN2: NX_Q8WWU7

Explore proteomics data for ITLN2 at MOPED


See ITLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_543154.1  
ENSEMBL proteins: 
 ENSP00000357008  

ITLN2 Human Recombinant Protein Products:

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antibodies-online antibodies for ITLN2 (18 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FIBC: Fibrinogen C domain containing

2 InterPro protein domains:
 IPR014716 Fibrinogen_a/b/g_C_1
 IPR002181 Fibrinogen_a/b/g_C_dom

Graphical View of Domain Structure for InterPro Entry Q8WWU7

ProtoNet protein and cluster: Q8WWU7

UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
Similarity: Contains 1 fibrinogen C-terminal domain


Find genes that share domains with ITLN2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ITLN2_HUMAN, Q8WWU7
Function: May play a role in the defense system against pathogens (By similarity)

Animal Models:

   genOway: Develop your customized and physiologically relevant rodent model for ITLN2

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ITLN2_HUMAN, Q8WWU7: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytoskeleton1
golgi apparatus1
lysosome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with ITLN2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITLN2
Interactions:

    Search GeneGlobe Interaction Network for ITLN2

1 Interacting protein for ITLN2 (Q8WWU73) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
EGFRP005333I2D: score=1 
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ITLN2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ITLN2 gene: 
NM_080878.2  

Unigene Cluster for ITLN2:

Intelectin 2
Hs.385631  [show with all ESTs]
Unigene Representative Sequence: AY358905
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368029(uc001fxd.3 uc009wts.3 uc010pju.2) ENST00000494442
ENST00000490489
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Additional mRNA sequence: 

AY065973.1 AY358905.1 BC117225.1 BC143339.1 BC143341.1 

1 DOTS entry:

DT.97838744 

12 AceView cDNA sequences:

BE045344 AY358905 BM993101 NM_080878 AY065973 BF515308 BM998678 BM993198 
BX505934 BI821675 BG482966 BE327604 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ITLN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGCATTGGA
ITLN2 Expression
About this image


ITLN2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 Lung (Respiratory System)
ITLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ITLN2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.385631

UniProtKB/Swiss-Prot: ITLN2_HUMAN, Q8WWU7
Tissue specificity: Expressed only in the small intestine

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ITLN2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
--
(see all 4)
Uncharacterized protein
(see all 4)
79(a)
74(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
2(164389016-164391058)
2(164388807-164415382)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
65(a)
1 → many
GL343929.1(67124-79262)
African clawed frog
(Xenopus laevis)
Amphibia XEEL2 embryonic epidermal lectin 74.54(n)    AB105372.1 
zebrafish
(Danio rerio)
Actinopterygii BX571811.16
BX927082.16
(see all 9)
Uncharacterized protein
(see all 9)
57(a)
55(a)
(see all 9)
many ↔ many
many ↔ many
(see all 9)
7(34487233-34488622) ENSDARG00000036085
7(30839382-30842644) ENSDARG00000053649


ENSEMBL Gene Tree for ITLN2 (if available)
TreeFam Gene Tree for ITLN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ITLN2 gene
ITLN12  
1 SIMAP similar gene for ITLN2 using alignment to 3 protein entries:     ITLN2_HUMAN (see all proteins):
ITLN1

Find genes that share paralogs with ITLN2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ITLN2 (see all 361)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22434701,2
C--160914332(+) GGAGTG/ACAATG 1 -- ds50019Minor allele frequency- A:0.02NA WA CSA EA 369
rs1401940151,2
--160914366(+) CTCTGC/TCTCCC 1 -- ds50010--------
rs618021661,2
C,F--160914529(+) GCCTCG/AGCCTC 1 -- ds50012Minor allele frequency- A:0.50NA 4
rs730120911,2
C,F--160914606(+) TTTTTT/AATATC 1 -- ds50013Minor allele frequency- A:0.09WA CSA 122
rs1838398021,2
C--160914885(+) TAGCCA/GGGGTT 1 -- ut310--------
rs2002571251,2
--160914905(+) GTTCTC/TGCCCT 1 -- ut310--------
rs67019201,2
C,F,H--160914917(+) ACACCG/ACAGAG 1 -- ut31 ese312Minor allele frequency- A:0.03NS EA NA WA EU 2625
rs1869343621,2
C--160914955(+) CAGCCA/GCCTCC 2 A V mis10--------
rs1499289061,2
C,F--160915019(+) AAAGGC/TGGAGA 2 T A mis12Minor allele frequency- T:0.00NA EU 5873
rs1836528831,2
C--160915037(+) ACACTA/GACGGG 2 Q * stg10--------

HapMap Linkage Disequilibrium report for ITLN2 (160914815 - 160924589 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ITLN2: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ITLN2
DNA2.0 Custom Variant and Variant Library Synthesis for ITLN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609874    OMIM disorders: --


Find genes that share disorders with ITLN2           About GenesLikeMe

Genetic Association Database (GAD): ITLN2
Human Genome Epidemiology (HuGE) Navigator: ITLN2 (4 documents)

Export disorders for ITLN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ITLN2 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with ITLN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PubMed id 11181563)1, 2, 3 Lee J.K....Pierce M. (Glycobiology 2001)
  2. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (Diabetes 2010)
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  5. Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution. (PubMed id 23643964)1 Yan J....Feng L. (Dev. Comp. Immunol. 2013)
  6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. (PubMed id 17983620)9 French A.T....Pemberton A.D. (Int. J. Parasitol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 142683 HGNC: 20599 AceView: ITLN2 Ensembl:ENSG00000158764 euGenes: HUgn142683
ECgene: ITLN2 H-InvDB: ITLN2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ITLN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ITLN2 gene:
Search GeneIP for patents involving ITLN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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