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Aliases for ITLN1 Gene

Aliases for ITLN1 Gene

  • Intelectin 1 2 3 5
  • Omentin 2 3 4
  • Intelectin 1 (Galactofuranose Binding) 2 3
  • Intestinal Lactoferrin Receptor 3 4
  • Galactofuranose-Binding Lectin 3 4
  • Endothelial Lectin HL-1 3 4
  • ITLN-1 3 4
  • INTL 3 4
  • ITLN 3 4
  • LFR 3 4
  • Intelectin-1 3
  • HIntL 3
  • HL-1 3
  • HL1 3

External Ids for ITLN1 Gene

Previous GeneCards Identifiers for ITLN1 Gene

  • GC01M156578
  • GC01M157624
  • GC01M158063
  • GC01M157659
  • GC01M159112
  • GC01M132202

Summaries for ITLN1 Gene

GeneCards Summary for ITLN1 Gene

ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Ciliary Dyskinesia, Primary, 3, With Or Without Situs Inversus and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are IL-7 Signaling Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2.

UniProtKB/Swiss-Prot for ITLN1 Gene

  • Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.

Gene Wiki entry for ITLN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN1 Gene

Genomics for ITLN1 Gene

Regulatory Elements for ITLN1 Gene

Enhancers for ITLN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ITLN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITLN1 Gene

Chromosome:
1
Start:
160,876,539 bp from pter
End:
160,885,170 bp from pter
Size:
8,632 bases
Orientation:
Minus strand

Genomic View for ITLN1 Gene

Genes around ITLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN1 Gene

Proteins for ITLN1 Gene

  • Protein details for ITLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWA0-ITLN1_HUMAN
    Recommended name:
    Intelectin-1
    Protein Accession:
    Q8WWA0
    Secondary Accessions:
    • Q5IWS4
    • Q5VYI4
    • Q6YDJ3
    • Q9NP67

    Protein attributes for ITLN1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34962 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for ITLN1 Gene

neXtProt entry for ITLN1 Gene

Post-translational modifications for ITLN1 Gene

Other Protein References for ITLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITLN1 (Intelectin-1/Omentin)
  • Abcam antibodies for ITLN1
  • Cloud-Clone Corp. Antibodies for ITLN1

No data available for DME Specific Peptides for ITLN1 Gene

Domains & Families for ITLN1 Gene

Protein Domains for ITLN1 Gene

Suggested Antigen Peptide Sequences for ITLN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWA0

UniProtKB/Swiss-Prot:

ITLN1_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ITLN1: view

No data available for Gene Families for ITLN1 Gene

Function for ITLN1 Gene

Molecular function for ITLN1 Gene

UniProtKB/Swiss-Prot Function:
Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.

Gene Ontology (GO) - Molecular Function for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ITLN1: view
genes like me logo Genes that share phenotypes with ITLN1: view

Animal Models for ITLN1 Gene

MGI Knock Outs for ITLN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITLN1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITLN1 Gene

Localization for ITLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. {ECO:0000250 UniProtKB:O88310}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITLN1 Gene COMPARTMENTS Subcellular localization image for ITLN1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
chloroplast 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031225 anchored component of membrane IEA --
GO:0031526 brush border membrane IEA,ISS --
GO:0043235 receptor complex IDA 23382219
GO:0045121 membrane raft IEA,ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ITLN1: view

Pathways & Interactions for ITLN1 Gene

genes like me logo Genes that share pathways with ITLN1: view

Pathways by source for ITLN1 Gene

1 R&D Systems pathway for ITLN1 Gene

Interacting Proteins for ITLN1 Gene

Gene Ontology (GO) - Biological Process for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 16531507
GO:0009624 response to nematode IEA,ISS --
GO:0046326 positive regulation of glucose import IDA 16531507
genes like me logo Genes that share ontologies with ITLN1: view

No data available for SIGNOR curated interactions for ITLN1 Gene

Drugs & Compounds for ITLN1 Gene

(3) Drugs for ITLN1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ITLN1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with ITLN1: view

Transcripts for ITLN1 Gene

mRNA/cDNA for ITLN1 Gene

Unigene Clusters for ITLN1 Gene

Intelectin 1 (galactofuranose binding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN1 Gene

No ASD Table

Relevant External Links for ITLN1 Gene

GeneLoc Exon Structure for
ITLN1
ECgene alternative splicing isoforms for
ITLN1

Expression for ITLN1 Gene

mRNA expression in normal human tissues for ITLN1 Gene

mRNA differential expression in normal tissues according to GTEx for ITLN1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x20.0), Heart - Atrial Appendage (x15.9), and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for ITLN1 Gene

This gene is overexpressed in Pancreatic juice (43.6) and Rectum (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITLN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ITLN1 Gene:

ITLN1

SOURCE GeneReport for Unigene cluster for ITLN1 Gene:

Hs.50813

mRNA Expression by UniProt/SwissProt for ITLN1 Gene:

Q8WWA0-ITLN1_HUMAN
Tissue specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.
genes like me logo Genes that share expression patterns with ITLN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for ITLN1 Gene

Orthologs for ITLN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Itln1 34
  • 82.32 (n)
  • 81.15 (a)
Itln1 16
Gm9765 35
  • 80 (a)
OneToMany
Itln1 35
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ITLN1 34
  • 98.51 (n)
  • 96.81 (a)
ITLN1 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itln1 34
  • 82.32 (n)
  • 80.83 (a)
cow
(Bos Taurus)
Mammalia ITLN2 35
  • 78 (a)
ManyToMany
ITLN2 35
  • 76 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
-- 35
  • 78 (a)
ManyToMany
-- 35
  • 74 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127565 34
  • 67.77 (n)
  • 69.23 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC564958 34
  • 64.01 (n)
  • 63.04 (a)
BX571811.1 35
  • 59 (a)
ManyToMany
BX571811.2 35
  • 51 (a)
ManyToMany
BX927082.1 35
  • 56 (a)
ManyToMany
itln1 35
  • 45 (a)
ManyToMany
itln2 35
  • 56 (a)
ManyToMany
itln2 35
  • 49 (a)
ManyToMany
itln3 35
  • 47 (a)
ManyToMany
ITLN4 35
  • 52 (a)
ManyToMany
zgc:153219 35
  • 54 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 13 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
Species where no ortholog for ITLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN1 Gene

ENSEMBL:
Gene Tree for ITLN1 (if available)
TreeFam:
Gene Tree for ITLN1 (if available)

Paralogs for ITLN1 Gene

Paralogs for ITLN1 Gene

(1) SIMAP similar genes for ITLN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITLN1: view

Variants for ITLN1 Gene

Sequence variations from dbSNP and Humsavar for ITLN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2274907 - 160,882,036(+) GGTAG(A/T)CTGCT reference, missense
rs8144 - 160,876,668(+) CTCAA(C/G/T)GATAG reference, missense
rs1333062 -- 160,876,494(+) TCCTA(G/T)AGTGC downstream-variant-500B
rs2039415 -- 160,884,655(+) ATACC(C/T)TCACT intron-variant
rs2236515 -- 160,881,146(+) CAGCC(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITLN1 Gene

Variant ID Type Subtype PubMed ID
esv2672334 CNV deletion 23128226
esv3578225 CNV loss 25503493
esv3587719 CNV loss 21293372
nsv548057 CNV loss 21841781
nsv946457 CNV duplication 23825009

Variation tolerance for ITLN1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITLN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITLN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITLN1 Gene

Disorders for ITLN1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ITLN1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 3, with or without situs inversus
  • ciliary dyskinesia, primary, 3
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
lipid-rich carcinoma
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search ITLN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITLN1

Genetic Association Database (GAD)
ITLN1
Human Genome Epidemiology (HuGE) Navigator
ITLN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITLN1
genes like me logo Genes that share disorders with ITLN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITLN1 Gene

Publications for ITLN1 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee J.K. … Pierce M. (Glycobiology 2001) 2 3 4 22 65
  2. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. (PMID: 11313366) Tsuji S. … Seya T. (J. Biol. Chem. 2001) 2 3 4 22 65
  3. A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk. (PMID: 19000584) Pemberton A.D. … Holgate S.T. (J. Allergy Clin. Immunol. 2008) 3 22 46 65
  4. Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases. (PMID: 17295929) SchAoffler A. … Herfarth H. (Cardiovasc Diabetol 2007) 3 22 46 65
  5. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (PMID: 16531507) Yang R.-Z. … Gong D.-W. (Am. J. Physiol. 2006) 3 4 22 65

Products for ITLN1 Gene

  • Cloud-Clone Corp. Antibodies for ITLN1
  • Cloud-Clone Corp. Proteins for ITLN1
  • Cloud-Clone Corp Assay Kits for ITLN1

Sources for ITLN1 Gene

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