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Aliases for ITLN1 Gene

Aliases for ITLN1 Gene

  • Intelectin 1 (Galactofuranose Binding) 2 3
  • Omentin 2 3 4
  • INTL 3 4 6
  • LFR 3 4 6
  • Intestinal Lactoferrin Receptor 3 4
  • Galactofuranose-Binding Lectin 3 4
  • Endothelial Lectin HL-1 3 4
  • ITLN-1 3 4
  • ITLN 3 4
  • HL1 3 6
  • Intelectin-1 3
  • HIntL 3
  • HL-1 3

External Ids for ITLN1 Gene

Summaries for ITLN1 Gene

GeneCards Summary for ITLN1 Gene

ITLN1 (Intelectin 1 (Galactofuranose Binding)) is a Protein Coding gene. Diseases associated with ITLN1 include obesity and malignant pleural mesothelioma. Among its related pathways are IL-9 Signaling Pathways. An important paralog of this gene is ITLN2.

UniProtKB/Swiss-Prot for ITLN1 Gene

  • Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.

Gene Wiki entry for ITLN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN1 Gene

Genomics for ITLN1 Gene

Genomic Location for ITLN1 Gene

Start:
160,876,539 bp from pter
End:
160,885,170 bp from pter
Size:
8,632 bases
Orientation:
Minus strand

Genomic View for ITLN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN1 Gene

Regulatory Elements for ITLN1 Gene

Proteins for ITLN1 Gene

  • Protein details for ITLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWA0-ITLN1_HUMAN
    Recommended name:
    Intelectin-1
    Protein Accession:
    Q8WWA0
    Secondary Accessions:
    • Q5IWS4
    • Q5VYI4
    • Q6YDJ3
    • Q9NP67

    Protein attributes for ITLN1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34962 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked.

neXtProt entry for ITLN1 Gene

Proteomics data for ITLN1 Gene at MOPED

Post-translational modifications for ITLN1 Gene

Other Protein References for ITLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITLN1 Gene

Domains for ITLN1 Gene

Protein Domains for ITLN1 Gene

UniProtKB/Swiss-Prot:

ITLN1_HUMAN
Domain:
  • Contains 1 fibrinogen C-terminal domain.:
    • Q8WWA0
genes like me logo Genes that share domains with ITLN1: view

No data available for Gene Families for ITLN1 Gene

Function for ITLN1 Gene

Molecular function for ITLN1 Gene

UniProtKB/Swiss-Prot Function: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.

Gene Ontology (GO) - Molecular Function for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ITLN1: view
genes like me logo Genes that share phenotypes with ITLN1: view

Animal Models for ITLN1 Gene

MGI Knock Outs for ITLN1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITLN1 Gene

Localization for ITLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITLN1 Gene COMPARTMENTS Subcellular localization image for ITLN1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031225 anchored component of membrane IEA --
GO:0031526 brush border membrane ISS --
GO:0043235 receptor complex IDA 23382219
GO:0045121 membrane raft ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ITLN1: view

Pathways for ITLN1 Gene

SuperPathways for ITLN1 Gene

genes like me logo Genes that share pathways with ITLN1: view

Pathways by source for ITLN1 Gene

1 R&D Systems pathway for ITLN1 Gene

Gene Ontology (GO) - Biological Process for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 16531507
GO:0009624 response to nematode ISS --
GO:0046326 positive regulation of glucose import IDA 16531507
genes like me logo Genes that share ontologies with ITLN1: view

Compounds for ITLN1 Gene

(2) HMDB Compounds for ITLN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Iron
  • Armco iron
7439-89-6

(2) Novoseek inferred chemical compound relationships for ITLN1 Gene

Compound -log(P) Hits PubMed IDs
iron 12.9 5
glucose 12.1 5
genes like me logo Genes that share compounds with ITLN1: view

Transcripts for ITLN1 Gene

mRNA/cDNA for ITLN1 Gene

Unigene Clusters for ITLN1 Gene

Intelectin 1 (galactofuranose binding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN1 Gene

No ASD Table

Relevant External Links for ITLN1 Gene

GeneLoc Exon Structure for
ITLN1
ECgene alternative splicing isoforms for
ITLN1

Expression for ITLN1 Gene

mRNA expression in normal human tissues for ITLN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITLN1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (20.0), Heart - Atrial Appendage (15.9), and Colon - Transverse (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITLN1 Gene

SOURCE GeneReport for Unigene cluster for ITLN1 Gene Hs.50813

mRNA Expression by UniProt/SwissProt for ITLN1 Gene

Q8WWA0-ITLN1_HUMAN
Tissue specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.
genes like me logo Genes that share expressions with ITLN1: view

Orthologs for ITLN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITLN1 36
  • 98.51 (n)
  • 96.81 (a)
ITLN1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 77 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
ITLN2 37
  • 78 (a)
ManyToMany
ITLN2 37
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm9765 37
  • 80 (a)
OneToMany
Itln1 36
  • 82.32 (n)
  • 81.15 (a)
Itln1 16
Itln1 37
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 78 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Itln1 36
  • 82.32 (n)
  • 80.83 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127565 36
  • 67.77 (n)
  • 69.23 (a)
zebrafish
(Danio rerio)
Actinopterygii BX571811.1 37
  • 59 (a)
ManyToMany
BX571811.2 37
  • 51 (a)
ManyToMany
BX927082.1 37
  • 56 (a)
ManyToMany
itln1 37
  • 45 (a)
ManyToMany
itln2 37
  • 56 (a)
ManyToMany
itln2 37
  • 49 (a)
ManyToMany
itln3 37
  • 47 (a)
ManyToMany
ITLN4 37
  • 52 (a)
ManyToMany
LOC564958 36
  • 64.01 (n)
  • 63.04 (a)
zgc:153219 37
  • 54 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 12 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
-- 37
  • 13 (a)
ManyToMany
-- 37
  • 14 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
Species with no ortholog for ITLN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN1 Gene

ENSEMBL:
Gene Tree for ITLN1 (if available)
TreeFam:
Gene Tree for ITLN1 (if available)

Paralogs for ITLN1 Gene

Paralogs for ITLN1 Gene

Selected SIMAP similar genes for ITLN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITLN1: view

Variants for ITLN1 Gene

Sequence variations from dbSNP and Humsavar for ITLN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8144 - 160,876,668(+) CTCAA(C/G)GATAG missense, reference
rs1333062 -- 160,876,494(+) TCCTA(G/T)AGTGC downstream-variant-500B
rs2039415 -- 160,884,655(+) ATACC(C/T)TCACT intron-variant
rs2236515 -- 160,881,146(+) CAGCC(C/T)TCTGT intron-variant
rs2274905 -- 160,879,577(+) TCCTG(G/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITLN1 Gene

Variant ID Type Subtype PubMed ID
esv2672334 CNV Deletion 23128226

Relevant External Links for ITLN1 Gene

HapMap Linkage Disequilibrium report
ITLN1

Disorders for ITLN1 Gene

(5) Novoseek inferred disease relationships for ITLN1 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 58.7 5
obesity 53.3 4
insulin sensitivity 46.1 3
cardiovascular diseases 18.2 1
inflammatory bowel diseases 10.8 1

Relevant External Links for ITLN1

Genetic Association Database (GAD)
ITLN1
Human Genome Epidemiology (HuGE) Navigator
ITLN1
genes like me logo Genes that share disorders with ITLN1: view

No data available for UniProtKB/Swiss-Prot for ITLN1 Gene

Publications for ITLN1 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee J.K. … Pierce M. (Glycobiology 2001) 2 3 4 23
  2. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. (PMID: 11313366) Tsuji S. … Seya T. (J. Biol. Chem. 2001) 2 3 4 23
  3. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. (PMID: 11747454) Suzuki Y.A. … Loennerdal B. (Biochemistry 2001) 3 4 23
  4. Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases. (PMID: 17295929) SchAoffler A. … Herfarth H. (Cardiovasc Diabetol 2007) 3 23 49
  5. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (PMID: 16531507) Yang R.-Z. … Gong D.-W. (Am. J. Physiol. 2006) 3 4 23

Products for ITLN1 Gene

Sources for ITLN1 Gene

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