Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ITLN1 Gene

protein-coding   GIFtS: 58
GCID: GC01M160846

Intelectin 1 (Galactofuranose Binding)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Intelectin 1 (Galactofuranose Binding)1 2     ITLN-12 3
INTL2 3 5     HL12 5
LFR2 3 5     HL-12
Endothelial Lectin HL-12 3     hIntL2
Galactofuranose-Binding Lectin2 3     intelectin-12
Intestinal Lactoferrin Receptor2 3     omentin2
ITLN2 3     Omentin3

External Ids:    HGNC: 182591   Entrez Gene: 556002   Ensembl: ENSG000001799147   OMIM: 6098735   UniProtKB: Q8WWA03   

Export aliases for ITLN1 gene to outside databases

Previous GC identifers: GC01M156578 GC01M157624 GC01M158063 GC01M157659 GC01M159112 GC01M132202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ITLN1 Gene:
ITLN1 (intelectin 1 (galactofuranose binding)) is a protein-coding gene. Diseases associated with ITLN1 include malignant pleural mesothelioma, and obesity, association with. An important paralog of this gene is ITLN2.

UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
Function: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes.
Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system
against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components
containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism

Gene Wiki entry for ITLN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITLN1 gene promoter:
         Max1   NCX/Ncx   Tal-1beta   C/EBPalpha   CHOP-10   HEN1   JunD   Zic1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITLN1 promoter sequence
   Search Chromatin IP Primers for ITLN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.3

ITLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITLN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160846:  view genomic region     (about GC identifiers)

Start:
160,846,329 bp from pter      End:
160,854,960 bp from pter
Size:
8,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0 (See protein sequence)
Recommended Name: Intelectin-1 precursor  
Size: 313 amino acids; 34962 Da
Subunit: Homotrimer; disulfide-linked
Developmental stage: Found in fetal small intestine and thymus
Mass spectrometry: Mass=35500; Method=MALDI; Range=19-298; Source=PubMed:17621593;
Secondary accessions: Q5IWS4 Q5VYI4 Q6YDJ3 Q9NP67

Explore the universe of human proteins at neXtProt for ITLN1: NX_Q8WWA0

Explore proteomics data for ITLN1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn163
  • Modification sites at PhosphoSitePlus

  • See ITLN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060095.2  
    ENSEMBL proteins: 
     ENSP00000323587  

    ITLN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ITLN1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITLN1
    GenScript Custom Purified and Recombinant Proteins Services for ITLN1
    Novus Biologicals ITLN1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ITLN1
    Cloud-Clone Corp. Proteins for ITLN1

    ITLN1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITLN1
    R&D Systems Antibodies for ITLN1 (Intelectin-1/Omentin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITLN1
    Novus Biologicals ITLN1 Antibodies
    Abcam antibodies for ITLN1
    Cloud-Clone Corp. Antibodies for ITLN1
    ThermoFisher Antibodies for ITLN1
    LSBio Antibodies in human, mouse, rat for ITLN1

    ITLN1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of ITLN1
    OriGene Custom Assay Services for ITLN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITLN1
    Enzo Life Sciences assays for ITLN1
    Cloud-Clone Corp. ELISAs for ITLN1
    Cloud-Clone Corp. CLIAs for ITLN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry Q8WWA0

    ProtoNet protein and cluster: Q8WWA0

    UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
    Similarity: Contains 1 fibrinogen C-terminal domain


    ITLN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITLN1_HUMAN, Q8WWA0
    Function: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes.
    Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system
    against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components
    containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism

    Phenotypes:
         3 GenomeRNAi human phenotypes for ITLN1:

     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Itln1):
     normal 

    ITLN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itln1tm1Lex for ITLN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITLN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITLN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITLN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITLN1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ITLN1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITLN1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITLN1
    Predesigned siRNA for gene silencing in human, mouse, rat ITLN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITLN1

    Clone
    Products:
         
    OriGene clones in human, mouse for ITLN1 (see all 5)
    OriGene ORF clones in mouse, rat for ITLN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITLN1 (NM_017625)
    Sino Biological Human cDNA Clone for ITLN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITLN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITLN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITLN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ITLN1_HUMAN, Q8WWA0: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0031225anchored component of membrane IEA--
    GO:0031526brush border membrane ISS--
    GO:0043235receptor complex IDA--
    GO:0045121membrane raft ISS--

    ITLN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ITLN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1IL-9 Signaling Pathways
    Adipocytokines and Insulin Signaling0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITLN1
        Adipocytokines & Insulin Signaling




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITLN1
    Interactions:

        Search GeneGlobe Interaction Network for ITLN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ITLN1 (Q8WWA03 ENSP000003235874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LTFP027883, ENSP000002317514I2D: score=1 STRING: ENSP00000231751
    BCL2ENSP000003296234STRING: ENSP00000329623
    CCND1ENSP000002275074STRING: ENSP00000227507
    CERS2ENSP000002716884STRING: ENSP00000271688
    NLKENSP000003846254STRING: ENSP00000384625
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA16531507
    GO:0009624response to nematode ISS--
    GO:0046326positive regulation of glucose import IDA16531507

    ITLN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITLN1

    2 HMDB Compounds for ITLN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--

    2 Novoseek inferred chemical compound relationships for ITLN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 12.9 6 10598021 (2), 11747454 (2), 17766154 (1)
    glucose 12.1 6 17311679 (4), 16531507 (1)



    ITLN1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ITLN1 gene: 
    NM_017625.2  

    Unigene Cluster for ITLN1:

    Intelectin 1 (galactofuranose binding)
    Hs.50813  [show with all ESTs]
    Unigene Representative Sequence: AY549722
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326245(uc001fxc.3) ENST00000487531 ENST00000464077
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITLN1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITLN1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITLN1
    Predesigned siRNA for gene silencing in human, mouse, rat ITLN1
    Clone
    Products:
         
    OriGene clones in human, mouse for ITLN1 (see all 5)
    OriGene ORF clones in mouse, rat for ITLN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITLN1 (NM_017625)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITLN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITLN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITLN1
      QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
      QuantiFast Probe-based Assays in human, mouse, rat ITLN1

    Additional mRNA sequence: 

    AB036706.1 AF271386.1 AK000029.1 AK222533.1 AY065972.1 AY157361.1 AY157362.1 AY358359.1 
    AY549722.1 AY619691.1 AY619692.1 BC020664.1 CR457224.1 

    1 DOTS entry:

    DT.112293 

    Selected AceView cDNA sequences (see all 97):

    AA551795 AA552527 CB268384 BM818953 NM_017625 C00989 BC020664 BQ082937 
    CB268083 BM830752 AI318094 AW628242 AF271386 CB266028 CA407417 BQ694078 
    CB266342 CB266042 CB269374 AI076155 AI660866 CB270175 AI187143 BM826735 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ITLN1 expression in normal human tissues (normalized intensities)      ITLN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATCCCAAG
    ITLN1 Expression
    About this image


    ITLN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ITLN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITLN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50813

    UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
    Tissue specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not
    in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the
    small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid
    and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus

        Custom PCR Arrays for ITLN1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITLN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITLN1
    QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
    QuantiFast Probe-based Assays in human, mouse, rat ITLN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ITLN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itln11 , 5 intelectin 1 (galactofuranose binding)1, 5 82.32(n)1
    81.15(a)1
      1 (79.49 cM)5
    164291  NM_010584.31  NP_034714.11 
     1715181225 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    64(a)
    1 → many
    GL343929.1(67124-79262)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1001275651 uncharacterized LOC100127565 67.77(n)
    69.23(a)
      100127565  NM_001112933.2  NP_001106404.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5649581 intelectin-1-like 64.01(n)
    63.04(a)
      564958  XM_688277.2  XP_693369.2 


    ENSEMBL Gene Tree for ITLN1 (if available)
    TreeFam Gene Tree for ITLN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ITLN1 gene
    ITLN22  
    1 SIMAP similar gene for ITLN1 using alignment to 2 protein entries:     ITLN1_HUMAN (see all proteins):
    ITLN2

    ITLN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ITLN1 (see all 340)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46569531,2
    C,F,A,H--160845842(+) TGTCTT/CCTTCT 1 -- int119Minor allele frequency- C:0.45NA NS EA WA CSA 932
    rs46569541,2
    F,H--160845890(+) AGCCAC/GTGCAC 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs1505000321,2
    --160845916(+) CATCGC/TAACAT 1 -- int10--------
    rs784106061,2
    F--160845958(+) AGTCAC/GTAAGG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs124096091,2
    C,F,A,H--160845996(+) GTATAC/TCTCCT 1 -- int115Minor allele frequency- T:0.46NA WA CSA EA 518
    rs1836753901,2
    --160846034(+) GGACGC/TTTTTC 1 -- int10--------
    rs1403286221,2
    C--160846110(+) TGGATA/GAAATG 1 -- int10--------
    rs1887314571,2
    --160846134(+) TGCCCA/TGTATG 1 -- int10--------
    rs584757821,2
    C,F--160846273(+) CTTTCG/AAAATT 1 -- int14Minor allele frequency- A:0.10WA CSA 126
    rs13330621,2
    C,F,A,H--160846284(+) TCCTAG/TAGTGC 1 -- int129Minor allele frequency- T:0.41EA NA NS WA CSA 3959

    HapMap Linkage Disequilibrium report for ITLN1 (160846329 - 160854960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ITLN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672334CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITLN1
    DNA2.0 Custom Variant and Variant Library Synthesis for ITLN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609873    OMIM disorders: --

    Selected diseases for ITLN1 (see all 29):    About MalaCards
    malignant pleural mesothelioma    obesity, association with    crohn's disease    kawasaki disease
    inflammatory bowel disease    endotheliitis    ankylosing spondylitis    insulin resistance
    spondylitis    polycystic ovary syndrome    obesity    ulcerative colitis
    peritonitis    osteoarthritis    coronary artery disease    diabetes mellitus
    asthma    multiple sclerosis    ischemia    atherosclerosis


    ITLN1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ITLN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 58.7 5 17329619 (2), 17970534 (1), 19009016 (1), 15952917 (1)
    obesity 53.3 4 17329619 (2), 16891032 (1), 17970534 (1)
    insulin sensitivity 46.1 3 20380714 (2), 17329619 (1)
    cardiovascular diseases 18.2 1 17970534 (1)
    inflammatory bowel diseases 10.8 1 17295929 (1)

    Genetic Association Database (GAD): ITLN1
    Human Genome Epidemiology (HuGE) Navigator: ITLN1 (13 documents)

    Export disorders for ITLN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ITLN1 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with ITLN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. (PubMed id 11313366)1, 2, 3, 9 Tsuji S.... Seya T. (J. Biol. Chem. 2001)
    2. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PubMed id 11181563)1, 2, 3, 9 Lee J.K....Pierce M. (Glycobiology 2001)
    3. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. (PubMed id 11747454)1, 2, 9 Suzuki Y.A.... Loennerdal B. (Biochemistry 2001)
    4. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (PubMed id 16531507)1, 2, 9 Yang R.-Z.... Gong D.-W. (Am. J. Physiol. 2006)
    5. Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases. (PubMed id 17295929)1, 4, 9 SchAoffler A....Herfarth H. (Cardiovasc Diabetol 2007)
    6. A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk. (PubMed id 19000584)1, 4, 9 Pemberton A.D....Holgate S.T. (J. Allergy Clin. Immunol. 2008)
    7. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (Diabetes 2010)
    8. Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. (PubMed id 20014019)1, 4 Dubinsky M.C....Rotter J.I. (Inflamm. Bowel Dis. 2010)
    9. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    10. Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1, 4 Amre D.K....Levy E. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55600 HGNC: 18259 AceView: ITLN1 Ensembl:ENSG00000179914 euGenes: HUgn55600
    ECgene: ITLN1 H-InvDB: ITLN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ITLN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ITLN1 gene:
    Search GeneIP for patents involving ITLN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITLN1
     EMD Millipore Kits and Assays for the Analysis of ITLN1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ITLN1 (Intelectin-1/Omentin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ITLN1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ITLN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITLN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ITLN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITLN1   OriGene Custom Protein Services for ITLN1  

     
     
     Block miRNA regulation of human, mouse, rat ITLN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ITLN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITLN1 Predesigned siRNA for gene silencing in human, mouse, rat ITLN1
     QuantiFast Probe-based Assays in human, mouse, rat ITLN1 QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
     Custom PCR Arrays for ITLN1 Search Chromatin IP Primers for ITLN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITLN1  Search GeneGlobe Interaction Network for ITLN1
     Regulatory tfbs in ITLN1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ITLN1 GenScript cDNA clones with any tag delivered in your preferred vector for ITLN1
     GenScript Custom Assay Services for ITLN1 GenScript Custom overexpressing Cell Line Services for ITLN1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ITLN1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ITLN1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for ITLN1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ITLN1 antibodies
     ITLN1 proteins
     Antibodies for ITLN1
     See all of Abcam's Antibodies, Kits and Proteins for ITLN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ITLN1
     Proteins for ITLN1
     Antibodies for ITLN1
     ELISAs for ITLN1
     CLIAs for ITLN1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ITLN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ITLN1
     SwitchGear Promoter luciferase reporter plasmids for ITLN1
     ThermoFisher Antibodies for ITLN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITLN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITLN1
     LSBio Antibodies in human, mouse, rat for ITLN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITLN1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4