Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITLN1 Gene

protein-coding   GIFtS: 55
GCID: GC01M160846

intelectin 1 (galactofuranose binding)
 Explore 18 diseases affiliated with
ITLN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITLN1    

Aliases
for ITLN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Intelectin 1 (Galactofuranose Binding)1 2     Intestinal Lactoferrin Receptor2 3
LFR1 2 3 5     ITLN-12 3
ITLN1 2 3     HL12 5
INTL2 3 5     FLJ200221
HL-11 2     Intelectin-11
HIntL1     Omentin3
Endothelial Lectin HL-12 3     Omentin3
Galactofuranose-Binding Lectin2 3     

External Ids:    HGNC: 182591   Entrez Gene: 556002   Ensembl: ENSG000001799147   OMIM: 6098735   UniProtKB: Q8WWA03   

Export aliases for ITLN1 gene to outside databases

Previous GC identifers: GC01M156578 GC01M157624 GC01M158063 GC01M157659 GC01M159112 GC01M132202


Summaries
for ITLN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
Function: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases
AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against
microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing
galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism

Gene Wiki entry for ITLN1


Genomic Views
for ITLN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITLN1 gene promoter:
         Max1   NCX/Ncx   Tal-1beta   C/EBPalpha   CHOP-10   HEN1   JunD   Zic1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITLN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITLN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.3

ITLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITLN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160846:  view genomic region     (about GC identifiers)

Start:
 160,846,329 bp from pter      End:
 160,854,960 bp from pter
Size:
 8,632 bases      Orientation:
 minus strand

Proteins
for ITLN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0 (See protein sequence)
Recommended Name: Intelectin-1 precursor  
Size: 313 amino acids; 34962 Da
Subunit: Homotrimer; disulfide-linked
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts (By similarity)
Developmental stage: Found in fetal small intestine and thymus
Mass spectrometry: Mass=35500; Method=MALDI; Range=19-298; Source=PubMed:17621593;
Secondary accessions: Q5IWS4 Q5VYI4 Q6YDJ3 Q9NP67

Explore the universe of human proteins at neXtProt for ITLN1: NX_Q8WWA0

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWA0

    • ITLN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060095.2  
    ENSEMBL proteins: 
     ENSP00000323587  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ITLN1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ITLN1 
    GenScript Custom Purified and Recombinant Proteins Services for ITLN1
    Novus Biologicals ITLN1 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ITLN1
    Uscn Proteins for ITLN1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0031225anchored to membrane IEA--
    GO:0031526brush border membrane ISS--
    GO:0045121membrane raft ISS--


    ITLN1 for ontologies           About GeneDecksing



    ITLN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITLN1
    R&D Systems Antibodies for ITLN1 (Intelectin-1/Omentin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITLN1 
    GenScript Custom Superior Antibodies Services for ITLN1
    Novus Biologicals ITLN1 Antibodies
    Search for Antibodies for ITLN1 at Abcam  
    Uscn Antibodies for ITLN1
    ThermoFisher Antibodies for ITLN1

    Assay Products for ITLN1: 
    EMD Millipore Kits and Assays for the Analysis of ITLN1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITLN1
    Enzo Life Sciences assays for ITLN1
    Uscn ELISAs and CLIAs for ITLN1

    Protein Domains /
    Families
    for ITLN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITLN1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q8WWA0

    ProtoNet protein and cluster: Q8WWA0

    UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ITLN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
    Function: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases
    AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against
    microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing
    galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITLN1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITLN1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITLN1 (see all 7)
    OriGene shRNA RFP: ITLN1
    OriGene siRNA: ITLN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITLN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ITLN1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ITLN1 (NM_017625)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITLN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ITLN1
    Search LifeMap BioReagents cell lines for ITLN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0030246carbohydrate binding ----


    ITLN1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ITLN1:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         Mouse knock-out Itln1tm1Lex for ITLN1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Itln1):
     normal 

    ITLN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ITLN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL-9 Signaling Pathways
    		Adipocytokines & Insulin Signaling0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for ITLN1
        Adipocytokines & Insulin Signaling



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITLN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for ITLN1 (Q8WWA03 ENSP000003235874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LTFP027883, ENSP000002317514I2D: score=1 STRING: ENSP00000231751
    BCL2ENSP000003296234STRING: ENSP00000329623
    CCND1ENSP000002275074STRING: ENSP00000227507
    CERS2ENSP000002716884STRING: ENSP00000271688
    NLKENSP000003846254STRING: ENSP00000384625
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA16531507
    GO:0007165signal transduction IEA--
    GO:0009624response to nematode ISS--
    GO:0046326positive regulation of glucose import IDA16531507


    ITLN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITLN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITLN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITLN1

    2 HMDB Compounds for ITLN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    2 Novoseek chemical compound relationships for ITLN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 12.9 6 10598021 (2), 11747454 (2), 17766154 (1)
    glucose 12.1 6 17311679 (4), 16531507 (1)

    Search CenterWatch for drugs/clinical trials and news about ITLN1 

    Transcripts
    for ITLN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITLN1 gene: 
    NM_017625.2  

    Unigene Cluster for ITLN1:

    Intelectin 1 (galactofuranose binding)
    Hs.50813  [show with all ESTs]
    Unigene Representative Sequence: AY549722
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326245(uc001fxc.3) ENST00000487531 ENST00000464077

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITLN1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITLN1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITLN1 (see all 7)
    OriGene shRNA RFP: ITLN1
    OriGene siRNA: ITLN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITLN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ITLN1 (NM_017625)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITLN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITLN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITLN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITLN1

    Additional cDNA sequence: 

    AB036706.1 AF271386.1 AK000029.1 AK222533.1 AY065972.1 AY157361.1 AY157362.1 AY358359.1 
    AY549722.1 AY619691.1 AY619692.1 BC020664.1 CR457224.1 

    1 DOTS entry:

    DT.112293 

    24/97 AceView cDNA sequences (see all 97):

    CB268083 NM_017625 BM818953 AA552527 C00989 AA551795 CB268384 BM830752 
    AI318094 BC020664 BQ082937 AI076155 AA483813 BQ695027 CB269374 AA573898 
    AY549722 AW073901 CA406675 AA573925 BG540424 CD105100 AW628242 BQ694078 

    GeneLoc Exon Structure


    Expression
    for ITLN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITLN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATCCCAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITLN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ITLN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITLN1

    SOURCE GeneReport for Unigene cluster: Hs.50813

    UniProtKB/Swiss-Prot: ITLN1_HUMAN, Q8WWA0
    Tissue specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in
    fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small
    intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a
    lesser degree, in the uterus, spleen, prostate, lymph node and thymus

        SABiosciences Custom PCR Arrays for ITLN1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITLN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITLN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITLN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1

    Orthologs
    for ITLN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ITLN1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 65(a)
    		 1 → many
    		 GL343929.1(67124-79262)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX571811.16
    BX927082.26
    (see all 9)    		 --
    		 59(a)
    57(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 7(34487233-34488622)
    7(30839382-30842644)


    ENSEMBL Gene Tree for ITLN1 (if available)
    TreeFam Gene Tree for ITLN1 (if available) 

    Paralogs
    for ITLN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITLN1 gene
    ITLN22  
    1 SIMAP similar gene for ITLN1 using alignment to 2 protein entries:     ITLN1_HUMAN (see all proteins):
    ITLN2

    ITLN1 for paralogs           About GeneDecksing



    Genomic Variants
    for ITLN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/273 NCBI SNPs in ITLN1 are shown (see all 273)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs46569531,2
    		C,F,A,H,--160845842(+) TGTCTT/CCTTCT 1 -- int119Minor allele frequency- C:0.45NA NS EA WA CSA 932
    rs46569541,2
    		H,--160845890(+) AGCCAC/GTGCAC 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs1505000321,2
    		--160845916(+) CATCGC/TAACAT 1 -- int10--------
    rs784106061,2
    		--160845958(+) AGTCAC/GTAAGG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs124096091,2
    		C,F,A,H,--160845996(+) GTATAC/TCTCCT 1 -- int115Minor allele frequency- T:0.46NA WA CSA EA 518
    rs1836753901,2
    		--160846034(+) GGACGC/TTTTTC 1 -- int10--------
    rs1403286221,2
    		--160846110(+) TGGATA/GAAATG 1 -- int10--------
    rs1887314571,2
    		--160846134(+) TGCCCA/TGTATG 1 -- int10--------
    rs584757821,2
    		C,F,--160846273(+) CTTTCG/AAAATT 1 -- int14Minor allele frequency- A:0.10WA CSA 126
    rs13330621,2
    		C,F,A,H,--160846284(+) TCCTAG/TAGTGC 1 -- int129Minor allele frequency- T:0.41EA NA NS WA CSA 3959

    HapMap Linkage Disequilibrium report for ITLN1 (160846329 - 160854960 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ITLN1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITLN1
    DNA2.0 Custom Variant and Variant Library Synthesis for ITLN1

    Disorders / Diseases
    for ITLN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITLN1 for disorders           About GeneDecksing

    OMIM gene information: 609873    OMIM disorders: --

    18 diseases for ITLN1:    About MalaCards
    malignant pleural mesothelioma    type 2 diabetes mellitus    inflammatory bowel disease    polycystic ovary syndrome
    ankylosing spondylitis    insulin resistance    arterial calcification    diabetes mellitus
    ulcerative colitis    spondylitis    obesity, association with    obesity
    crohn's disease    peritonitis    asthma    atherosclerosis
    thyroiditis    prostatitis

    5 Novoseek disease relationships for ITLN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 58.7 5 17329619 (2), 17970534 (1), 19009016 (1), 15952917 (1)
    obesity 53.3 4 17329619 (2), 16891032 (1), 17970534 (1)
    insulin sensitivity 46.1 3 20380714 (2), 17329619 (1)
    cardiovascular diseases 18.2 1 17970534 (1)
    inflammatory bowel diseases 10.8 1 17295929 (1)

    Human Genome Epidemiology (HuGE) Navigator: ITLN1 (13 documents)

    Export disorders for ITLN1 gene to outside databases

    Publications
    for ITLN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITLN1 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with ITLN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. (PubMed id 11313366)1, 2, 3, 9 Tsuji S.... Seya T. (2001)
    2. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PubMed id 11181563)1, 2, 3, 9 Lee J.K....Pierce M. (2001)
    3. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. (PubMed id 11747454)1, 2, 9 Suzuki Y.A.... Loennerdal B. (2001)
    4. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (PubMed id 16531507)1, 2, 9 Yang R.-Z.... Gong D.-W. (2006)
    5. The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins. (PubMed id 14720597)1, 2 Chang B.Y.... Hedrick J.L. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Capture of heat-killed Mycobacterium bovis bacillus Calmette-GuAcrin by intelectin-1 deposited on cell surfaces. (PubMed id 19179460)1, 9 Tsuji S....Shibata Y. (2009)
    10. Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer. (PubMed id 17621593)2, 9 Tsuji S.... Shibata Y. (2007)

    External Searches for ITLN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITLN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55600 HGNC: 18259 AceView: ITLN1 Ensembl:ENSG00000179914 euGenes: HUgn55600
    ECgene: ITLN1 H-InvDB: ITLN1

    Other Databases showing ITLN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITLN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITLN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ITLN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITLN1 gene:
    Search GeneIP for patents involving ITLN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ITLN1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Kits and Assays for the Analysis of ITLN1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITLN1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITLN1 (Intelectin-1/Omentin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ITLN1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITLN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITLN1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ITLN1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITLN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITLN1   OriGene Custom Protein Services for ITLN1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITLN1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITLN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITLN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITLN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITLN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITLN1
     GenScript Custom Purified and Recombinant Proteins Services for ITLN1 GenScript cDNA clones with any tag delivered in your preferred vector for ITLN1
     GenScript Custom Assay Services for ITLN1 GenScript Custom Superior Antibodies Services for ITLN1
     GenScript Custom overexpressing Cell Line Services for ITLN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITLN1 promoter
     Search Chromatin IP Primers for ITLN1
     RT2 qPCR Primer Assay in human, mouse, rat ITLN1
     Search GNC Networks for ITLN1
     SABiosciences Custom PCR Arrays for ITLN1
     Search Tocris compounds for ITLN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Assays/Proteins for ITLN1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITLN1 antibodies
     ITLN1 proteins
     Search for Antibodies for ITLN1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ITLN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ITLN1




     ITLN1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ITLN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITLN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ITLN1
     SwitchGear Promoter luciferase reporter plasmids for ITLN1
     ThermoFisher Antibodies for ITLN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITLN1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ITLN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4