Aliases for ITK Gene
External Ids for ITK Gene
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITK Gene
ITK (IL2-Inducible T-Cell Kinase) is a Protein Coding gene. Diseases associated with ITK include lymphoproliferative syndrome 1 and lymphoproliferative syndrome, ebv-associated, autosomal, 1. Among its related pathways are PI-3K cascade and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include phospholipid binding and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is FER.
UniProtKB/Swiss-Prot for ITK Gene
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.