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Aliases for ITK Gene

Aliases for ITK Gene

  • IL2-Inducible T-Cell Kinase 2 3
  • Interleukin-2-Inducible T-Cell Kinase 3 4
  • IL-2-Inducible T-Cell Kinase 3 4
  • T-Cell-Specific Kinase 3 4
  • EC 2.7.10.2 4 64
  • Kinase EMT 3 4
  • EMT 3 4
  • LYK 3 4
  • Homolog Of Mouse T-Cell Itk/Tsk Tyrosine Kinase 6
  • Interleukin-2-Inducible T Cell Kinase 3
  • Homolog Of Mouse T-Cell Itk/Tsk 3
  • Tyrosine-Protein Kinase ITK/TSK 3
  • IL-2-Inducible T Cell Kinase 3
  • Tyrosine-Protein Kinase LYK 3
  • Tyrosine-Protein Kinase Lyk 4
  • EC 2.7.10 64
  • PSCTK2 3
  • LPFS1 3

External Ids for ITK Gene

Summaries for ITK Gene

Entrez Gene Summary for ITK Gene

  • This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITK Gene

ITK (IL2-Inducible T-Cell Kinase) is a Protein Coding gene. Diseases associated with ITK include lymphoproliferative syndrome 1 and lymphoproliferative syndrome, ebv-associated, autosomal, 1. Among its related pathways are PI-3K cascade and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include phospholipid binding and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for ITK Gene

  • Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.

Gene Wiki entry for ITK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITK Gene

Genomics for ITK Gene

Genomic Location for ITK Gene

Start:
157,142,933 bp from pter
End:
157,255,191 bp from pter
Size:
112,259 bases
Orientation:
Plus strand

Genomic View for ITK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITK Gene

Regulatory Elements for ITK Gene

Proteins for ITK Gene

  • Protein details for ITK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08881-ITK_HUMAN
    Recommended name:
    Tyrosine-protein kinase ITK/TSK
    Protein Accession:
    Q08881
    Secondary Accessions:
    • B2R752
    • Q32ML7

    Protein attributes for ITK Gene

    Size:
    620 amino acids
    Molecular mass:
    71831 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homooligomerizes; this association negatively regulates kinase activity (By similarity). Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK. Interacts with THEMIS (By similarity). Interacts with FASLG. Interacts with VAV1; this interaction is important for VAV1 localization and TCR-induced actin polarization.

    Three dimensional structures from OCA and Proteopedia for ITK Gene

neXtProt entry for ITK Gene

Proteomics data for ITK Gene at MOPED

Selected DME Specific Peptides for ITK Gene

Post-translational modifications for ITK Gene

  • Phosphorylated at Tyr-512 in the activation loop of the kinase domain by LCK. Subsequent autophosphorylation at Tyr-180 leads to the kinase activation. The autophosphorylated Tyr-180 lies within the substrate binding sequence of the SH3 domain.
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys119, Lys129, Lys138, Lys150, Lys242, Lys258, Lys280, Lys291, Lys310, Lys344, Lys412, Lys497, Lys519, and Lys523

Other Protein References for ITK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ITK Gene

Gene Families for ITK Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

ITK_HUMAN
Domain:
  • The N-terminal PH domain allows ITK to be recruited to the plasma membrane by an activated PI3 kinase. This domain contains also a proline-rich region (PRR). The adjoining domain is a SH3 domain, which binds to PRR (from itself or from other proteins). Next, a SH2 domain is required for binding tyrosine-phosphorylated substrates. In the C-terminal region, the kinase domain is required for tyrosine phosphorylation.:
    • Q08881
  • Contains 1 PH domain.:
    • Q08881
  • Contains 1 protein kinase domain.:
    • Q08881
  • Contains 1 SH2 domain.:
    • Q08881
  • Contains 1 SH3 domain.:
    • Q08881
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.:
    • Q08881
Similarity:
  • Contains 1 Btk-type zinc finger.:
    • Q08881
genes like me logo Genes that share domains with ITK: view

Function for ITK Gene

Molecular function for ITK Gene

GENATLAS Biochemistry: tyrosine kinase,72kDa,mainly expressed in T cells and natural killer(NK) cells,SRC family,Tec subfamily
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
UniProtKB/Swiss-Prot Induction: Through a myriad of surface receptors including the TCR/CD3 signaling complex, coreceptors, or chemokine receptors.

Enzyme Numbers (IUBMB) for ITK Gene

Gene Ontology (GO) - Molecular Function for ITK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 12186560
GO:0005102 NOT receptor binding IBA --
GO:0005515 protein binding IPI 12186560
genes like me logo Genes that share ontologies with ITK: view
genes like me logo Genes that share phenotypes with ITK: view

Animal Models for ITK Gene

MGI Knock Outs for ITK:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ITK Gene

Localization for ITK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITK Gene

Cytoplasm. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITK Gene COMPARTMENTS Subcellular localization image for ITK gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ITK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with ITK: view

Pathways for ITK Gene

genes like me logo Genes that share pathways with ITK: view

Gene Ontology (GO) - Biological Process for ITK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production ISS --
GO:0001865 NK T cell differentiation IBA --
GO:0002250 adaptive immune response ISS --
GO:0006468 protein phosphorylation --
GO:0006968 cellular defense response TAS 8364206
genes like me logo Genes that share ontologies with ITK: view

Compounds for ITK Gene

(2) HMDB Compounds for ITK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Drugbank Compounds for ITK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pazopanib
  • GW-786034
444731-52-6 target inhibitor
Staurosporine
62996-74-1 target

(11) Novoseek inferred chemical compound relationships for ITK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 78 99
phosphatidylinositol 49.2 8
phosphotyrosine 38.5 2
threonine 37.3 2
benzimidazole 33.8 3

(1) PharmGKB related drug/compound annotations for ITK Gene

Drug/compound Annotation
pazopanib
genes like me logo Genes that share compounds with ITK: view

Transcripts for ITK Gene

Unigene Clusters for ITK Gene

IL2-inducible T-cell kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: - -
SP6:
SP7: -
SP8: -
SP9:
SP10:

ExUns: 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2:
SP3: -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ITK Gene

GeneLoc Exon Structure for
ITK
ECgene alternative splicing isoforms for
ITK

Expression for ITK Gene

mRNA expression in normal human tissues for ITK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITK Gene

This gene is overexpressed in Whole Blood (18.7), Spleen (6.0), and Small Intestine - Terminal Ileum (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITK Gene

SOURCE GeneReport for Unigene cluster for ITK Gene Hs.558348

mRNA Expression by UniProt/SwissProt for ITK Gene

Q08881-ITK_HUMAN
Tissue specificity: T-cell lines and natural killer cell lines
genes like me logo Genes that share expressions with ITK: view

Orthologs for ITK Gene

This gene was present in the common ancestor of animals.

Orthologs for ITK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITK 36
  • 99.3 (n)
  • 99.68 (a)
ITK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITK 36
  • 90.43 (n)
  • 95.65 (a)
ITK 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITK 36
  • 90.75 (n)
  • 94.84 (a)
ITK 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itk 36
  • 88.05 (n)
  • 94.35 (a)
Itk 16
Itk 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITK 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITK 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itk 36
  • 87.69 (n)
  • 94.52 (a)
chicken
(Gallus gallus)
Aves ITK 36
  • 74.66 (n)
  • 78.12 (a)
ITK 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITK 37
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii itk 36
itk 36
  • 61.8 (n)
  • 60.03 (a)
itk 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 37
  • 36 (a)
OneToMany
Btk29A 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-24 38
  • 24 (a)
spe-8 38
  • 31 (a)
F22B3.8 38
  • 29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8009 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
ManyToMany
Species with no ortholog for ITK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ITK Gene

ENSEMBL:
Gene Tree for ITK (if available)
TreeFam:
Gene Tree for ITK (if available)

Paralogs for ITK Gene

Paralogs for ITK Gene

Selected SIMAP similar genes for ITK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITK: view

Variants for ITK Gene

Sequence variations from dbSNP and Humsavar for ITK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25775 -- 157,244,908(+) TCCCC(A/G)TATGA intron-variant
rs25776 -- 157,246,215(+) GTTAA(C/T)TAAAA intron-variant
rs25778 -- 157,223,590(+) ATACC(A/G)AGCAT intron-variant
rs25779 -- 157,220,371(-) GAAGA(C/G)TTGAG intron-variant
rs25780 -- 157,220,242(+) AGATG(G/T)AAAAT intron-variant

Relevant External Links for ITK Gene

HapMap Linkage Disequilibrium report
ITK
Human Gene Mutation Database (HGMD)
ITK

No data available for Structural Variations from Database of Genomic Variants (DGV) for ITK Gene

Disorders for ITK Gene

(1) OMIM Diseases for ITK Gene (186973)

UniProtKB/Swiss-Prot

ITK_HUMAN
  • Lymphoproliferative syndrome 1 (LPFS1) [MIM:613011]: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. {ECO:0000269 PubMed:19425169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ITK Gene

(6) Novoseek inferred disease relationships for ITK Gene

Disease -log(P) Hits PubMed IDs
x-linked agammaglobulinemia 81.4 2
asthma allergic 58.4 7
asthma 11.1 2
pneumonia 0 2
inflammation 0 6

Relevant External Links for ITK

Genetic Association Database (GAD)
ITK
Human Genome Epidemiology (HuGE) Navigator
ITK
genes like me logo Genes that share disorders with ITK: view

Publications for ITK Gene

  1. Identification, cloning, and characterization of a novel human T- cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. (PMID: 8364206) Gibson S. … Mills G.B. (Blood 1993) 2 3 4 23
  2. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. (PMID: 9312162) Heyeck S.D. … Berg L.J. (J. Biol. Chem. 1997) 3 4 23
  3. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. (PMID: 12186560) Perez-Villar J.J. … Kanner S.B. (Biochemistry 2002) 3 4 23
  4. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. (PMID: 16159638) Graves P.E. … Martinez F.D. (J. Allergy Clin. Immunol. 2005) 3 23 49
  5. Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors. (PMID: 17060314) Qi Q. … August A. (J. Biol. Chem. 2006) 3 4 23

Products for ITK Gene

  • Addgene plasmids for ITK

Sources for ITK Gene

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