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Aliases for ITIH6 Gene

Aliases for ITIH6 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 6 2 3 5
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 6 2 3
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H5-Like Protein 3 4
  • Inter-Alpha Inhibitor H5-Like Protein 3 4
  • ITIH5L 3 4
  • Inter-Alpha (Globulin) Inhibitor H5-Like 2
  • ITI-Like Protein 3
  • DJ14O9.1 3
  • UNQ6369 3

External Ids for ITIH6 Gene

Previous HGNC Symbols for ITIH6 Gene

  • ITIH5L

Summaries for ITIH6 Gene

Entrez Gene Summary for ITIH6 Gene

  • The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]

GeneCards Summary for ITIH6 Gene

ITIH6 (Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 6) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH6 Gene

Genomics for ITIH6 Gene

Regulatory Elements for ITIH6 Gene

Enhancers for ITIH6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITIH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITIH6 Gene

54,748,899 bp from pter
54,798,240 bp from pter
49,342 bases
Minus strand

Genomic View for ITIH6 Gene

Genes around ITIH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITIH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITIH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH6 Gene

Proteins for ITIH6 Gene

  • Protein details for ITIH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H6
    Protein Accession:
    Secondary Accessions:
    • A6NN03

    Protein attributes for ITIH6 Gene

    1313 amino acids
    Molecular mass:
    143187 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ITIH6 Gene

Proteomics data for ITIH6 Gene at MOPED

Post-translational modifications for ITIH6 Gene

  • Glycosylation at Asn 83, Asn 374, Asn 540, Asn 594, Asn 971, and Asn 1231
  • Modification sites at PhosphoSitePlus

Other Protein References for ITIH6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITIH6 Gene

Domains & Families for ITIH6 Gene

Suggested Antigen Peptide Sequences for ITIH6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VIT domain.
  • Belongs to the ITIH family.
  • Contains 1 VIT domain.
  • Contains 1 VWFA domain.
  • Belongs to the ITIH family.
genes like me logo Genes that share domains with ITIH6: view

No data available for Gene Families for ITIH6 Gene

Function for ITIH6 Gene

genes like me logo Genes that share phenotypes with ITIH6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ITIH6 Gene

Localization for ITIH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH6 Gene


Subcellular locations from

Jensen Localization Image for ITIH6 Gene COMPARTMENTS Subcellular localization image for ITIH6 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ITIH6 Gene

Pathways & Interactions for ITIH6 Gene

SuperPathways for ITIH6 Gene

No Data Available

Interacting Proteins for ITIH6 Gene

Gene Ontology (GO) - Biological Process for ITIH6 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITIH6 Gene

Drugs & Compounds for ITIH6 Gene

No Compound Related Data Available

Transcripts for ITIH6 Gene

mRNA/cDNA for ITIH6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITIH6 Gene

Inter-alpha-trypsin inhibitor heavy chain family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH6 Gene

No ASD Table

Relevant External Links for ITIH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITIH6 Gene

mRNA expression in normal human tissues for ITIH6 Gene

mRNA differential expression in normal tissues according to GTEx for ITIH6 Gene

This gene is overexpressed in Muscle - Skeletal (x34.2), Breast - Mammary Tissue (x6.3), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for ITIH6 Gene

This gene is overexpressed in Cerebrospinal fluid (62.9) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITIH6 Gene

SOURCE GeneReport for Unigene cluster for ITIH6 Gene Hs.454272

genes like me logo Genes that share expression patterns with ITIH6: view

Protein tissue co-expression partners for ITIH6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ITIH6 Gene

Orthologs for ITIH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Itih5l-ps 35
  • 79.02 (n)
  • 71.45 (a)
Itih5l-ps 16
(Pan troglodytes)
Mammalia ITIH5L 35
  • 99.44 (n)
  • 99.09 (a)
ITIH6 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ITIH6 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia ITIH6 36
  • 47 (a)
(Gallus gallus)
Aves ITIH6 35
  • 57.41 (n)
  • 47.07 (a)
ITIH6 36
  • 45 (a)
(Anolis carolinensis)
Reptilia ITIH6 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488634 35
  • 54.37 (n)
  • 48.11 (a)
(Danio rerio)
Actinopterygii itih6 35
  • 52.62 (n)
  • 45.18 (a)
itih6 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
-- 36
  • 30 (a)
-- 36
  • 22 (a)
Species with no ortholog for ITIH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH6 Gene

Gene Tree for ITIH6 (if available)
Gene Tree for ITIH6 (if available)

Paralogs for ITIH6 Gene

Paralogs for ITIH6 Gene

(2) SIMAP similar genes for ITIH6 Gene using alignment to 1 proteins: Pseudogenes for ITIH6 Gene

genes like me logo Genes that share paralogs with ITIH6: view

Variants for ITIH6 Gene

Sequence variations from dbSNP and Humsavar for ITIH6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34188213 - 54,758,915(+) CCTCC(C/G)CACAC reference, missense
rs34004499 - 54,758,393(+) GCGGC(A/G)GATGA reference, missense
rs17316491 - 54,755,097(+) CATCC(A/C/G)AGTTT reference, missense
rs35355718 - 54,751,224(+) AGGTA(C/G/T)CCTCG reference, missense
rs747694703 -- 54,753,892(+) GCCCT(A/G)TACTC intron-variant

Variation tolerance for ITIH6 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITIH6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ITIH6 Gene

Disorders for ITIH6 Gene

Relevant External Links for ITIH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITIH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITIH6 Gene

Publications for ITIH6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ITIH6 Gene

Sources for ITIH6 Gene