ITIH6 Gene
protein-coding GIFtS: 39
GCID: GC0XM054775
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inter-alpha-trypsin inhibitor heavy chain family, member...(Previous name: inter-alpha (globulin) inhibitor H5-like )
(Previous symbol: ITIH5L)
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Aliases
for ITIH6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 61 2 | | Inter-Alpha (Globulin) Inhibitor H5-Like1 | | ITIH5L1 2 3 | | DJ14O9.11 | | UNQ63691 2 | | Inter-Alpha-Trypsin Inhibitor Heavy Chain H62 | | Inter-Alpha Inhibitor H5-Like Protein2 3 | | ITI-Like Protein2 | | Inter-Alpha-Trypsin Inhibitor Heavy Chain H5-Like Protein2 3 | | |
Export aliases for ITIH6 gene to outside databases |
Summaries
for ITIH6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ITIH6:
The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalphatrypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chainconfers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactionswith the components of the extracellular matrix. (provided by RefSeq, Sep 2009)
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Genomic Views
for ITIH6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ITIH6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ITIH6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22-p11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.22-p11.21ITIH6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM054775: view genomic region
(about GC identifiers)
Start:
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54,775,332 bp from pter |
End:
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54,824,673 bp from pter |
Size:
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49,342 bases |
Orientation:
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minus strand |
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Proteins
for ITIH6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ITIH6_HUMAN, Q6UXX5 (See
protein sequence)Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H6 precursor Size: 1313 amino acids; 143187 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: A6NN03Explore the universe of human proteins at neXtProt for ITIH6: NX_Q6UXX5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXX5
ITIH6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940912.1
ENSEMBL proteins: ENSP00000218436
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
ITIH6 for ontologies About GeneDecksing
ITIH6 Antibody Products:
Assay Products for ITIH6: |
Protein
Domains /
Families
for ITIH6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ITIH6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXX5ProtoNet protein and cluster: Q6UXX5 2 Blocks protein families: IPB002035 Von Willebrand factor type A domain signature IPB010600 Inter-alpha-trypsin inhibitor heavy chain
UniProtKB/Swiss-Prot: ITIH6_HUMAN, Q6UXX5Similarity: Belongs to the ITIH familySimilarity: Contains 1 VIT domainSimilarity: Contains 1 VWFA domain |
Function
for ITIH6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for ITIH6 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITIH6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
ITIH6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ITIH6:
|
Pathways & Interactions
for ITIH6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITIH6
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030212 | hyaluronan metabolic process |
IEA | -- |
ITIH6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ITIH6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ITIH6
Search CenterWatch for drugs/clinical trials and news about ITIH6
|
Transcripts
for ITIH6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ITIH6 gene: NM_198510.2 Unigene Cluster for ITIH6: Inter-alpha-trypsin inhibitor heavy chain family, member 6 Hs.454272 [show with all ESTs]Unigene Representative Sequence: NM_1985102 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000218436(uc004dtj.2) ENST00000498398
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ITIH6 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITIH6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH6 |
Additional cDNA sequence: AY358170.1 1 DOTS entry: DT.75166579 10 AceView cDNA sequences: BQ448179 NM_198510 AY358170 CA413764 BQ181512 AI902890 BM800708 BQ428136 AL596553 AI902889
GeneLoc Exon Structure
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Expression
for ITIH6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ITIH6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ITIH6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITIH6
SOURCE GeneReport for Unigene cluster: Hs.454272
SABiosciences Custom PCR Arrays for ITIH6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITIH6
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ITIH6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITIH6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH6 |
Orthologs
for ITIH6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ITIH6 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ITIH5L1 |
inter-alpha (globulin) inhibitor H5-like |
55.02(n)
44.8(a) |
|
430871 XM_428421.3 XP_428421.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ITIH5L6 |
-- |
57(a) |
1 ↔ 1 |
1(205600845-205619356) |
zebrafish
(Danio rerio) |
Actinopterygii |
itih61 |
inter-alpha-trypsin inhibitor heavy chain family, member more |
52.68(n)
45.82(a) |
|
565328 XM_688605.3 XP_693697.3 |
ENSEMBL Gene Tree for ITIH6 (if available)
TreeFam Gene Tree for ITIH6 (if available) |
Paralogs
for ITIH6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ITIH6 gene
- ITIH52 ITIH12 ITIH32 ITIH22 ITIH42
2 SIMAP similar genes for ITIH6 using alignment to 1 protein entry: ITIH6_HUMAN:ITIH3 ITIH4
ITIH6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ITIH6
PGOHUM00000241791
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Genomic Variants
for ITIH6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ITIH6 (54775332 - 54824673 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ITIH6: --
Locus Specific Mutation Databases (LSDB): ITIH6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITIH6 |
|
Disorders
/ Diseases
for ITIH6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ITIH6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ITIH6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ITIH6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
|
External Searches for ITIH6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ITIH6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ITIH6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ITIH6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ITIH6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ITIH6 gene:
Search GeneIP for patents involving ITIH6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ITIH6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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