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Aliases for ITIH6 Gene

Aliases for ITIH6 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 6 2 3
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H5-Like Protein 3 4
  • Inter-Alpha Inhibitor H5-Like Protein 3 4
  • ITIH5L 3 4
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H6 3
  • Inter-Alpha (Globulin) Inhibitor H5-Like 2
  • ITI-Like Protein 3
  • DJ14O9.1 3
  • UNQ6369 3

External Ids for ITIH6 Gene

Previous Symbols for ITIH6 Gene

  • ITIH5L

Summaries for ITIH6 Gene

Entrez Gene Summary for ITIH6 Gene

  • The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]

GeneCards Summary for ITIH6 Gene

ITIH6 (Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 6) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH6 Gene

Genomics for ITIH6 Gene

Genomic Location for ITIH6 Gene

Start:
54,748,899 bp from pter
End:
54,798,240 bp from pter
Size:
49,342 bases
Orientation:
Minus strand

Genomic View for ITIH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITIH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH6 Gene

No data available for Regulatory Elements for ITIH6 Gene

Proteins for ITIH6 Gene

  • Protein details for ITIH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXX5-ITIH6_HUMAN
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H6
    Protein Accession:
    Q6UXX5
    Secondary Accessions:
    • A6NN03

    Protein attributes for ITIH6 Gene

    Size:
    1313 amino acids
    Molecular mass:
    143187 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ITIH6 Gene

Proteomics data for ITIH6 Gene at MOPED

Post-translational modifications for ITIH6 Gene

  • Glycosylation at Asn83, Asn374, Asn540, Asn594, Asn971, and Asn1231

Other Protein References for ITIH6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITIH6 Gene

Domains for ITIH6 Gene

UniProtKB/Swiss-Prot:

ITIH6_HUMAN
Domain:
  • Contains 1 VIT domain.:
    • Q6UXX5
  • Contains 1 VWFA domain.:
    • Q6UXX5
Family:
  • Belongs to the ITIH family.:
    • Q6UXX5
genes like me logo Genes that share domains with ITIH6: view

No data available for Gene Families for ITIH6 Gene

Function for ITIH6 Gene

Gene Ontology (GO) - Molecular Function for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with ITIH6: view
genes like me logo Genes that share phenotypes with ITIH6: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITIH6 Gene

Localization for ITIH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH6 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ITIH6: view

Pathways for ITIH6 Gene

SuperPathways for ITIH6 Gene

No Data Available

Interacting Proteins for ITIH6 Gene

Gene Ontology (GO) - Biological Process for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030212 hyaluronan metabolic process IEA --
genes like me logo Genes that share ontologies with ITIH6: view

No data available for Pathways by source for ITIH6 Gene

Transcripts for ITIH6 Gene

mRNA/cDNA for ITIH6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITIH6 Gene

Inter-alpha-trypsin inhibitor heavy chain family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH6 Gene

No ASD Table

Relevant External Links for ITIH6 Gene

GeneLoc Exon Structure for
ITIH6
ECgene alternative splicing isoforms for
ITIH6

Expression for ITIH6 Gene

mRNA expression in normal human tissues for ITIH6 Gene

mRNA differential expression in normal tissues according to GTEx for ITIH6 Gene

This gene is overexpressed in Muscle - Skeletal (34.2), Breast - Mammary Tissue (6.3), and Prostate (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ITIH6 Gene

SOURCE GeneReport for Unigene cluster for ITIH6 Gene Hs.454272

genes like me logo Genes that share expressions with ITIH6: view

Orthologs for ITIH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITIH5L 36
  • 99.44 (n)
  • 99.09 (a)
ITIH6 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itih5l-ps 36
  • 79.02 (n)
  • 71.45 (a)
Itih5l-ps 16
oppossum
(Monodelphis domestica)
Mammalia ITIH6 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITIH6 37
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITIH6 36
  • 57.41 (n)
  • 47.07 (a)
ITIH6 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITIH6 37
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488634 36
  • 54.37 (n)
  • 48.11 (a)
zebrafish
(Danio rerio)
Actinopterygii itih6 36
  • 52.62 (n)
  • 45.18 (a)
itih6 37
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 22 (a)
OneToMany
Species with no ortholog for ITIH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH6 Gene

ENSEMBL:
Gene Tree for ITIH6 (if available)
TreeFam:
Gene Tree for ITIH6 (if available)

Paralogs for ITIH6 Gene

Paralogs for ITIH6 Gene

Selected SIMAP similar genes for ITIH6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ITIH6 Gene

genes like me logo Genes that share paralogs with ITIH6: view

Variants for ITIH6 Gene

Sequence variations from dbSNP and Humsavar for ITIH6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2157482 -- 54,765,664(+) agtgg(C/T)gcaat intron-variant
rs4826611 -- 54,783,123(+) gcatt(G/T)aataa intron-variant
rs5914155 -- 54,754,578(+) ggggg(A/G)ccaca intron-variant
rs5914156 -- 54,784,781(+) gtttg(C/G)aggct intron-variant
rs5915175 -- 54,794,429(+) GGTTA(A/G)CCCCC intron-variant

Relevant External Links for ITIH6 Gene

HapMap Linkage Disequilibrium report
ITIH6
Human Gene Mutation Database (HGMD)
ITIH6
Locus Specific Mutation Databases (LSDB)
ITIH6

No data available for Structural Variations from Database of Genomic Variants (DGV) for ITIH6 Gene

Disorders for ITIH6 Gene

No disorders were found for ITIH6 Gene.

No data available for UniProtKB/Swiss-Prot for ITIH6 Gene

Publications for ITIH6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for ITIH6 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ITIH6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ITIH6
    • Block miRNA regulation of ITIH6 using miScript Target Protectors

    Sources for ITIH6 Gene

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