Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ITIH6 Gene

Aliases for ITIH6 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 6 2 3
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H5-Like Protein 3 4
  • Inter-Alpha Inhibitor H5-Like Protein 3 4
  • ITIH5L 3 4
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H6 3
  • Inter-Alpha (Globulin) Inhibitor H5-Like 2
  • ITI-Like Protein 3
  • DJ14O9.1 3
  • UNQ6369 3

External Ids for ITIH6 Gene

Previous HGNC Symbols for ITIH6 Gene

  • ITIH5L

Summaries for ITIH6 Gene

Entrez Gene Summary for ITIH6 Gene

  • The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]

GeneCards Summary for ITIH6 Gene

ITIH6 (Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 6) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH6 Gene

Genomics for ITIH6 Gene

Genomic Location for ITIH6 Gene

54,748,899 bp from pter
54,798,240 bp from pter
49,342 bases
Minus strand

Genomic View for ITIH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITIH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH6 Gene

No data available for Regulatory Elements for ITIH6 Gene

Proteins for ITIH6 Gene

  • Protein details for ITIH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H6
    Protein Accession:
    Secondary Accessions:
    • A6NN03

    Protein attributes for ITIH6 Gene

    1313 amino acids
    Molecular mass:
    143187 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ITIH6 Gene

Proteomics data for ITIH6 Gene at MOPED

Post-translational modifications for ITIH6 Gene

  • Glycosylation at Asn83, Asn374, Asn540, Asn594, Asn971, and Asn1231
  • Modification sites at PhosphoSitePlus

Other Protein References for ITIH6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITIH6 Gene

Domains for ITIH6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6UXX5
  • Contains 1 VIT domain.
  • Contains 1 VWFA domain.
  • Belongs to the ITIH family.
genes like me logo Genes that share domains with ITIH6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ITIH6 Gene

Function for ITIH6 Gene

Gene Ontology (GO) - Molecular Function for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with ITIH6: view
genes like me logo Genes that share phenotypes with ITIH6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITIH6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITIH6 Gene

Localization for ITIH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH6 Gene


Gene Ontology (GO) - Cellular Components for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ITIH6: view

No data available for Subcellular locations from COMPARTMENTS for ITIH6 Gene

Pathways for ITIH6 Gene

SuperPathways for ITIH6 Gene

No Data Available

Interacting Proteins for ITIH6 Gene

Gene Ontology (GO) - Biological Process for ITIH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030212 hyaluronan metabolic process IEA --
genes like me logo Genes that share ontologies with ITIH6: view

No data available for Pathways by source for ITIH6 Gene

Transcripts for ITIH6 Gene

mRNA/cDNA for ITIH6 Gene

(10) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITIH6 Gene

Inter-alpha-trypsin inhibitor heavy chain family, member 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITIH6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITIH6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH6 Gene

No ASD Table

Relevant External Links for ITIH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITIH6 Gene

mRNA expression in normal human tissues for ITIH6 Gene

mRNA differential expression in normal tissues according to GTEx for ITIH6 Gene

This gene is overexpressed in Muscle - Skeletal (34.2), Breast - Mammary Tissue (6.3), and Prostate (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ITIH6 Gene

SOURCE GeneReport for Unigene cluster for ITIH6 Gene Hs.454272

genes like me logo Genes that share expressions with ITIH6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ITIH6 Gene

Orthologs for ITIH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITIH5L 35
  • 99.44 (n)
  • 99.09 (a)
ITIH6 36
  • 99 (a)
(Mus musculus)
Mammalia Itih5l-ps 35
  • 79.02 (n)
  • 71.45 (a)
Itih5l-ps 16
(Monodelphis domestica)
Mammalia ITIH6 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia ITIH6 36
  • 47 (a)
(Gallus gallus)
Aves ITIH6 35
  • 57.41 (n)
  • 47.07 (a)
ITIH6 36
  • 45 (a)
(Anolis carolinensis)
Reptilia ITIH6 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488634 35
  • 54.37 (n)
  • 48.11 (a)
(Danio rerio)
Actinopterygii itih6 35
  • 52.62 (n)
  • 45.18 (a)
itih6 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
-- 36
  • 30 (a)
-- 36
  • 22 (a)
Species with no ortholog for ITIH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH6 Gene

Gene Tree for ITIH6 (if available)
Gene Tree for ITIH6 (if available)

Paralogs for ITIH6 Gene

Paralogs for ITIH6 Gene

Selected SIMAP similar genes for ITIH6 Gene using alignment to 1 proteins: Pseudogenes for ITIH6 Gene

genes like me logo Genes that share paralogs with ITIH6: view

Variants for ITIH6 Gene

Sequence variations from dbSNP and Humsavar for ITIH6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2157482 -- 54,765,664(+) agtgg(C/T)gcaat intron-variant
rs4826611 -- 54,783,123(+) gcatt(G/T)aataa intron-variant
rs5914155 -- 54,754,578(+) ggggg(A/G)ccaca intron-variant
rs5914156 -- 54,784,781(+) gtttg(C/G)aggct intron-variant
rs5915175 -- 54,794,429(+) GGTTA(A/G)CCCCC intron-variant

Relevant External Links for ITIH6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ITIH6 Gene

Disorders for ITIH6 Gene

No disorders were found for ITIH6 Gene.

No data available for UniProtKB/Swiss-Prot for ITIH6 Gene

Publications for ITIH6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for ITIH6 Gene

Sources for ITIH6 Gene

Back to Top