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ITIH5 Gene

protein-coding   GIFtS: 53
GCID: GC10M007601

Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member...

(Previous name: inter-alpha (globulin) inhibitor H5)
  Search for ITIH5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 51 2     ITI Heavy Chain H52 3
Inter-Alpha (Globulin) Inhibitor H51 2     Inter-Alpha-Trypsin Inhibitor Heavy Chain H52
Inter-Alpha-Inhibitor Heavy Chain 52 3     KIAA19533
ITI-HC52 3     

External Ids:    HGNC: 214491   Entrez Gene: 807602   Ensembl: ENSG000001232437   OMIM: 6097835   UniProtKB: Q86UX23   

Export aliases for ITIH5 gene to outside databases

Previous GC identifers: GC10M007754 GC10M007608 GC10M007641 GC10M007519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITIH5 Gene:
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI
proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are
also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers
of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for ITIH5 Gene:
ITIH5 (inter-alpha-trypsin inhibitor heavy chain family, member 5) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
Function: May act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITIH5 gene promoter:
         RP58   Tal-1   NRSF form 1   NRSF form 2   Tal-1beta   E47   FAC1   MRF-2   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITIH5 promoter sequence
   Search Chromatin IP Primers for ITIH5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITIH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p14

ITIH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M007601:  view genomic region     (about GC identifiers)

Start:
7,601,232 bp from pter      End:
7,708,961 bp from pter
Size:
107,730 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H5 precursor  
Size: 942 amino acids; 104576 Da
Caution: Conflict in position 933 in the human genome assembly due to a frameshift
Sequence caution: Sequence=CAI12953.1; Type=Frameshift; Positions=933; Sequence=CAI12955.1; Type=Frameshift;
Positions=933; Sequence=CAI16360.1; Type=Frameshift; Positions=933; Sequence=CAI16363.1; Type=Frameshift;
Positions=933;
Secondary accessions: Q5T664 Q5T665 Q5T666 Q6AI60 Q6UXB7 Q8TF48 Q8WYV2 Q96K70
Alternative splicing: 4 isoforms:  Q86UX2-1   Q86UX2-2   Q86UX2-3   Q86UX2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITIH5: NX_Q86UX2

Explore proteomics data for ITIH5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn97, Asn127, Asn231, Asn421, Asn508, Asn776, Asn795, Asn862
  • Modification sites at PhosphoSitePlus

  • See ITIH5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001851.1  NP_085046.5  NP_116206.4  

    ENSEMBL proteins: 
     ENSP00000256861   ENSP00000298441   ENSP00000419386   ENSP00000380333   ENSP00000387969  
     ENSP00000380332  

    ITIH5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ITIH5

     
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    Cloud-Clone Corp. ELISAs for ITIH5
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    Search eBioscience for ELISAs for ITIH5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013694 VIT
     IPR010600 ITI_HC_C
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q86UX2

    ProtoNet protein and cluster: Q86UX2

    2 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITIH5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITIH5_HUMAN, Q86UX2
    Function: May act as a tumor suppressor
    Induction: Down-regulated in breast tumors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    Find genes that share ontologies with ITIH5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITIH5:
     Bright nuclei  Decreased viability with pacli 

         1 MGI phenotypic allele for Itih5 (no phenotypes)

    Find genes that share phenotypes with ITIH5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itih5tm1Lex for ITIH5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITIH5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITIH5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITIH5

    miRNA
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    miRTarBase miRNAs that target ITIH5:
    hsa-mir-29a-3p (MIRT006553)

    Block miRNA regulation of human, mouse, rat ITIH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITIH5 (see all 20):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-4328 hsa-miR-548i hsa-miR-520d-5p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidITIH5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITIH5
    Predesigned siRNA for gene silencing in human, mouse, rat ITIH5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITIH5

    Clone
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    OriGene clones in human, mouse for ITIH5 (see all 17)
    OriGene ORF clones in mouse, rat for ITIH5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITIH5 (NM_001001851)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITIH5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITIH5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITIH5_HUMAN, Q86UX2: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ITIH5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITIH5
    Interactions:

        Search GeneGlobe Interaction Network for ITIH5

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030212hyaluronan metabolic process IEA--

    Find genes that share ontologies with ITIH5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITIH5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITIH5 gene (3 alternative transcripts): 
    NM_001001851.2  NM_030569.6  NM_032817.5  

    Unigene Cluster for ITIH5:

    Inter-alpha-trypsin inhibitor heavy chain family, member 5
    Hs.498586  [show with all ESTs]
    Unigene Representative Sequence: NM_030569
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256861(uc021pmu.1 uc021pmv.1) ENST00000298441 ENST00000473591
    ENST00000492668 ENST00000434980 ENST00000468389 ENST00000476417 ENST00000461751
    ENST00000397146 ENST00000446830 ENST00000397145(uc001ijr.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITIH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITIH5 (see all 20):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-4328 hsa-miR-548i hsa-miR-520d-5p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidITIH5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITIH5
    Predesigned siRNA for gene silencing in human, mouse, rat ITIH5
    Clone
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    OriGene clones in human, mouse for ITIH5 (see all 17)
    OriGene ORF clones in mouse, rat for ITIH5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITIH5 (NM_001001851)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITIH5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ITIH5
    OriGene qSTAR qPCR primer pairs in human, mouse for ITIH5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITIH5
      QuantiTect SYBR Green Assays in human, mouse, rat ITIH5
      QuantiFast Probe-based Assays in human, mouse, rat ITIH5

    Additional mRNA sequence: 

    AB075833.1 AK027375.1 AK027547.1 AK027831.1 AK027849.1 AK075381.1 AL833203.1 AY238437.1 
    AY358426.1 BC004282.1 BC050649.1 BC069714.1 BC136439.1 BC142961.1 

    11 DOTS entries:

    DT.100009907  DT.312019  DT.91914240  DT.92428096  DT.91743093  DT.91747458  DT.100778548  DT.432655 
    DT.302579  DT.101970708  DT.92428095 

    Selected AceView cDNA sequences (see all 158):

    AL550297 NM_001001851 BQ183379 BQ225649 AI379447 BX457074 AL540791 BM557411 
    AA873376 BM989082 BU165852 AK027547 BX486153 BQ214877 AK027831 AI339612 
    AI262953 BF689672 CD632634 CD366793 AI090076 BG333950 AL575373 AW473748 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITIH5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                -                             -     -                             -     -                     
    SP2:                                                              -     -                                                         
    SP3:                                                              -     -                                                         
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ITIH5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITIH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCTTTTC
    ITIH5 Expression
    About this image


    ITIH5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Gonad
             Mesonephric cells Mesonephros
    ITIH5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITIH5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498586

    UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
    Tissue specificity: Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary.
    Expression is barely detectable levels in all other tissues tested

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    QuantiFast Probe-based Assays in human, mouse, rat ITIH5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itih51 , 5 inter-alpha (globulin) inhibitor H51, 5 80.94(n)1
    78.49(a)1
      2 (6.94 cM)5
    2093781  NM_172471.21  NP_766059.11 
     101535715 
    chicken
    (Gallus gallus)
    Aves ITIH51 inter-alpha-trypsin inhibitor heavy chain family, member more 68.34(n)
    64.7(a)
      419111  XM_417299.4  XP_417299.4 
    lizard
    (Anolis carolinensis)
    Reptilia ITIH56
    inter-alpha-trypsin inhibitor heavy chain family, ...
    60(a)
    1 ↔ 1
    5(243144-292413)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118732 Transcribed sequence with weak similarity to protein more 72.5(n)    CF345794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itih51 inter-alpha (globulin) inhibitor H5 58.94(n)
    53.54(a)
      555366  XM_001331165.4  XP_001331201.3 


    ENSEMBL Gene Tree for ITIH5 (if available)
    TreeFam Gene Tree for ITIH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITIH5 gene
    ITIH12  ITIH32  ITIH22  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH5 using alignment to 5 protein entries:     ITIH5_HUMAN (see all proteins):
    ITIH3    ITIH2    ITIH4    DKFZp686G21125    ITIH1

    Find genes that share paralogs with ITIH5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITIH5 (see all 3108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57829831,2
    C--7523056(+) ttttt-/TT/T  
     TT
    /TTTT
    gagat
    2 -- int11NA 2
    rs343860891,2
    C--7542518(+) TTTTT-/T/TTT 
            
    GAGAT
    3 -- int11NA 2
    rs1839672641,2
    --7600810(+) GTTGTC/TCCGTT 2 -- ds50010--------
    rs70705231,2
    C,F,A,H--7600837(+) TCAACC/TGAAAT 2 -- ds500124Minor allele frequency- T:0.16NS EA NA WA 2770
    rs1878196511,2
    C--7600851(+) AACGCG/TATCCA 2 -- ds50010--------
    rs70694661,2
    C--7600879(+) CGGAGG/ATAGGA 2 -- ds50014Minor allele frequency- A:0.05NA WA EA 360
    rs786934801,2
    F--7600994(+) ACCCAA/GTAATG 2 -- ds50010--------
    rs1146233491,2
    --7601031(+) TGGGAC/TGCTAG 2 -- ds50010--------
    rs786415301,2
    C,F--7601066(+) GAGGTT/GTAAGA 2 -- ds50011Minor allele frequency- G:0.02WA 118
    rs38146961,2
    C,F,A,H--7601084(+) GTGTAC/TCTGAC 2 -- ds500121Minor allele frequency- T:0.17NS EA NA WA 2700

    HapMap Linkage Disequilibrium report for ITIH5 (7601232 - 7708961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITIH5 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669658CNV Deletion23128226
    esv2732317CNV Deletion23290073
    esv993971CNV Deletion20482838
    esv2732350CNV Deletion23290073
    esv2677970CNV Deletion23128226
    esv1437774CNV Deletion17803354
    esv2732273CNV Deletion23290073
    esv2732328CNV Deletion23290073
    esv2732295CNV Deletion23290073
    esv2732339CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609783    OMIM disorders: --


    Find genes that share disorders with ITIH5           About GenesLikeMe

    Genetic Association Database (GAD): ITIH5
    Human Genome Epidemiology (HuGE) Navigator: ITIH5 (3 documents)

    Export disorders for ITIH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITIH5 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ITIH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. (PubMed id 14744536)1, 2, 3, 9 Himmelfarb M.... Dahl E. (Cancer Lett. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Functional annotation of the human fat cell secretome. (PubMed id 22616691)1 Dahlman I....Arner P. (Arch. Physiol. Biochem. 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. ITIH-5 expression in human adipose tissue is increased in obesity. (PubMed id 21852814)1 Anveden A.8....Svensson P.A. (Obesity (Silver Spring) 2012)
    10. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PubMed id 22116950)4 Schuh-Huerta S.M....Reijo Pera R.A. (Hum. Reprod. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80760 HGNC: 21449 AceView: ITIH5 Ensembl:ENSG00000123243 euGenes: HUgn80760
    ECgene: ITIH5 H-InvDB: ITIH5

    (According to HUGE)
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    HUGE: KIAA1953

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITIH5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITIH5 gene:
    Search GeneIP for patents involving ITIH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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