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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITIH5 Gene

protein-coding   GIFtS: 50
GCID: GC10M007601

inter-alpha-trypsin inhibitor heavy chain family, member...

(Previous name: inter-alpha (globulin) inhibitor H5 )
 Explore 7 diseases affiliated with
ITIH5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITIH5    

Aliases
for ITIH5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 51 2     ITI Heavy Chain H52 3
Inter-Alpha (Globulin) Inhibitor H51 2     MGC108481
Inter-Alpha-Inhibitor Heavy Chain 52 3     Inter-Alpha-Trypsin Inhibitor Heavy Chain H52
ITI-HC52 3     KIAA19533

External Ids:    HGNC: 214491   Entrez Gene: 807602   Ensembl: ENSG000001232437   OMIM: 6097835   UniProtKB: Q86UX23   

Export aliases for ITIH5 gene to outside databases

Previous GC identifers: GC10M007754 GC10M007608 GC10M007641 GC10M007519


Summaries
for ITIH5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITIH5:
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI
proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also
structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy
chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
Function: May act as a tumor suppressor




Genomic Views
for ITIH5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITIH5 gene promoter:
         RP58   Tal-1   NRSF form 1   NRSF form 2   Tal-1beta   E47   FAC1   MRF-2   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITIH5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITIH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p14

ITIH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M007601:  view genomic region     (about GC identifiers)

Start:
 7,601,232 bp from pter      End:
 7,708,961 bp from pter
Size:
 107,730 bases      Orientation:
 minus strand

Proteins
for ITIH5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H5 precursor  
Size: 942 amino acids; 104576 Da
Subcellular location: Secreted (By similarity)
Caution: Conflict in position 933 in the human genome assembly due to a frameshift
Sequence caution: Sequence=CAI12953.1; Type=Frameshift; Positions=933; Sequence=CAI12955.1; Type=Frameshift;
Positions=933; Sequence=CAI16360.1; Type=Frameshift; Positions=933; Sequence=CAI16363.1; Type=Frameshift;
Positions=933;
Secondary accessions: Q5T664 Q5T665 Q5T666 Q6AI60 Q6UXB7 Q8TF48 Q8WYV2 Q96K70
Alternative splicing: 4 isoforms:  Q86UX2-1   Q86UX2-2   Q86UX2-3   Q86UX2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITIH5: NX_Q86UX2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UX2

    • ITIH5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001851.1  NP_085046.5  NP_116206.4  

    ENSEMBL proteins: 
     ENSP00000256861   ENSP00000298441   ENSP00000419386   ENSP00000380333   ENSP00000387969  
     ENSP00000380332  

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    Uscn Proteins for ITIH5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    ITIH5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ITIH5

    Protein Domains /
    Families
    for ITIH5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITIH5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR010600 ITI_HC_C
     IPR013694 VIT
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q86UX2

    ProtoNet protein and cluster: Q86UX2

    2 Blocks protein families:
    IPB002035 Von Willebrand factor type A domain signature
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    Function
    for ITIH5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
    Function: May act as a tumor suppressor
    Induction: Down-regulated in breast tumors

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ITIH5 (see all 20):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-4328 hsa-miR-548i hsa-miR-520d-5p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: ITIH5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITIH5 (see all 4)
    OriGene shRNA RFP: ITIH5
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITIH5

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ITIH5

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--


    ITIH5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ITIH5:
     Bright nuclei  Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Itih5tm1Lex for ITIH5
         1 MGI phenotypic allele for Itih5 (no phenotypes)

    ITIH5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ITIH5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITIH5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030212hyaluronan metabolic process IEA--


    ITIH5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITIH5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITIH5
    Search CenterWatch for drugs/clinical trials and news about ITIH5 

    Transcripts
    for ITIH5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITIH5 gene (3 alternative transcripts): 
    NM_001001851.2  NM_030569.6  NM_032817.5  

    Unigene Cluster for ITIH5:

    Inter-alpha-trypsin inhibitor heavy chain family, member 5
    Hs.498586  [show with all ESTs]
    Unigene Representative Sequence: NM_030569
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256861(uc021pmu.1 uc021pmv.1) ENST00000298441 ENST00000473591
    ENST00000492668 ENST00000434980 ENST00000468389 ENST00000476417 ENST00000461751
    ENST00000397146 ENST00000446830 ENST00000397145(uc001ijr.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITIH5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ITIH5 (see all 20):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-4328 hsa-miR-548i hsa-miR-520d-5p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: ITIH5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITIH5 (see all 4)
    OriGene shRNA RFP: ITIH5
    OriGene siRNA: ITIH5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITIH5
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH5

    Additional cDNA sequence: 

    AB075833.1 AK027375.1 AK027547.1 AK027831.1 AK027849.1 AK075381.1 AL833203.1 AY238437.1 
    AY358426.1 BC004282.1 BC050649.1 BC069714.1 BC136439.1 BC142961.1 

    11 DOTS entries:

    DT.100009907  DT.312019  DT.91914240  DT.92428096  DT.91743093  DT.91747458  DT.100778548  DT.432655 
    DT.302579  DT.101970708  DT.92428095 

    24/158 AceView cDNA sequences (see all 158):

    BM989082 AI379447 BQ225649 AA873376 AL550297 BX457074 AL540791 NM_001001851 
    BM557411 BU165852 BQ183379 BU732022 CD632636 BQ424178 AL544674 BC069714 
    AL833203 AI358033 AL544702 BQ214877 BM708175 CD632634 BG767953 AL550125 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITIH5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                -                             -     -                             -     -                     
    SP2:                                                              -     -                                                         
    SP3:                                                              -     -                                                         
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ITIH5

    Expression
    for ITIH5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITIH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTCTTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITIH5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    BoneMaxillary ProcessBone
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    TestisSeminiferous TubulesTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ITIH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITIH5

    SOURCE GeneReport for Unigene cluster: Hs.498586

    UniProtKB/Swiss-Prot: ITIH5_HUMAN, Q86UX2
    Tissue specificity: Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression
    is barely detectable levels in all other tissues tested

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    In Situ
    Assay Products:     
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    Orthologs
    for ITIH5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH5 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ITIH51 inter-alpha (globulin) inhibitor H5 67.75(n)
    63.78(a)    		   419111  XM_417299.3  XP_417299.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ITIH56
    		 --
    		 58(a)
    		 1 ↔ 1
    		 5(256045-288372)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.118732 Transcribed sequence with weak similarity to protein more 72.5(n)    CF345794.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii itih51 inter-alpha (globulin) inhibitor H5 58.63(n)
    52.57(a)    		   555366  XM_001331165.3  XP_001331201.2 


    ENSEMBL Gene Tree for ITIH5 (if available)
    TreeFam Gene Tree for ITIH5 (if available) 

    Paralogs
    for ITIH5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITIH5 gene
    ITIH12  ITIH32  ITIH22  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH5 using alignment to 5 protein entries:     ITIH5_HUMAN (see all proteins):
    ITIH3    ITIH2    ITIH4    DKFZp686G21125    ITIH1

    ITIH5 for paralogs           About GeneDecksing



    Genomic Variants
    for ITIH5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2651 NCBI SNPs in ITIH5 are shown (see all 2651)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1839672641,2
    		--7600810(+) GTTGTC/TCCGTT 2 -- ds50010--------
    rs70705231,2
    		C,F,A,H,--7600837(+) TCAACC/TGAAAT 2 -- ds500124Minor allele frequency- T:0.16NS EA NA WA 2770
    rs1878196511,2
    		--7600851(+) AACGCG/TATCCA 2 -- ds50010--------
    rs70694661,2
    		C,--7600879(+) CGGAGG/ATAGGA 2 -- ds50014Minor allele frequency- A:0.05NA WA EA 360
    rs786934801,2
    		--7600994(+) ACCCAA/GTAATG 2 -- ds50010--------
    rs1146233491,2
    		--7601031(+) TGGGAC/TGCTAG 2 -- ds50010--------
    rs786415301,2
    		C,F,--7601066(+) GAGGTT/GTAAGA 2 -- ds50011Minor allele frequency- G:0.02WA 118
    rs38146961,2
    		C,F,A,H,--7601084(+) GTGTAC/TCTGAC 2 -- ds500121Minor allele frequency- T:0.17NS EA NA WA 2700
    rs38146971,2
    		C,F,A,--7601154(+) ATTACG/TTTAAC 2 -- ds50015Minor allele frequency- T:0.12WA NA EA 362
    rs1112695711,2
    		--7601157(+) ACGTTG/AACATT 2 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ITIH5 (7601232 - 7708961 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ITIH5
         3 CNVs: 2848 3791 70916
         1 Indel: 70917

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    Disorders / Diseases
    for ITIH5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITIH5 for disorders           About GeneDecksing

    OMIM gene information: 609783    OMIM disorders: --

    7 diseases for ITIH5:    About MalaCards
    thyroiditis    thyroid cancer    osteoporosis    thyroid carcinoma
    alzheimer's disease    breast cancer    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ITIH5 (3 documents)

    Export disorders for ITIH5 gene to outside databases

    Publications
    for ITIH5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITIH5 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ITIH5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. (PubMed id 14744536)1, 2, 3, 9 Himmelfarb M.... Dahl E. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    5. Functional annotation of the human fat cell secretome. (PubMed id 22616691)1 Dahlman I....Arner P. (2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. ITIH-5 expression in human adipose tissue is increased in obesity. (PubMed id 21852814)1 Anveden A....Svensson P.A. (2012)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953)1 Karasik D....Demissie S. (2010)
    10. Gene expression profiling associated with the progres sion to poorly differentiated thyroid carcinomas. (PubMed id 19809427)1 Pita J.M....Leite V. (2009)

    External Searches for ITIH5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing ITIH5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80760 HGNC: 21449 AceView: ITIH5 Ensembl:ENSG00000123243 euGenes: HUgn80760
    ECgene: ITIH5 H-InvDB: ITIH5

    Other Databases showing ITIH5 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1953

    Specialized Databases showing ITIH5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITIH5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ITIH5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITIH5 gene:
    Search GeneIP for patents involving ITIH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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