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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITIH4 Gene

protein-coding GIFtS: 55
GCID: GC03M052846

inter-alpha-trypsin inhibitor heavy chain family, member...

(Previous name: inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive...)
(Previous symbol: ITIHL1)

Explore 42 diseases affiliated with
ITIH4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 4¹ ²		PK-120² ³
ITIHL1¹ ² ³ ⁵		ITI Heavy Chain H4² ³
IHRP¹ ² ³		GP120²
PK120² ³ ⁵		Inter-Alpha-Trypsin Inhibitor Heavy Chain H4²
H4P¹ ²		Inter-Alpha-Trypsin Inhibitor, Heavy Chain-Like, 1²
Inter-Alpha (Globulin) Inhibitor H4 (Plasma Kallikrein-Sensitive Glycoprotein)¹ ²		Plasma Kallikrein-Sensitive Glycoprotein 120²
Inter-Alpha-Inhibitor Heavy Chain 4² ³		Gp120³
Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein² ³		Plasma Kallikrein Sensitive Glycoprotein 120³
ITI-HC4² ³

External Ids:	HGNC: 6169¹	Entrez Gene: 3700²	Ensembl: ENSG00000055955⁷	OMIM: 600564⁵	UniProtKB: Q14624³

Export aliases for ITIH4 gene to outside databases

Previous GC identifers: GC03M051939 GC03M052098 GC03M052701 GC03M052804 GC03M052822

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITIH4:

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller

forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma.

This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: ITIH4_HUMAN, Q14624

Function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver

development or regeneration

Gene Wiki entry for ITIH4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITIH4 gene promoter:
c-Fos AP-2alpha isoform 3 AP-1 AP-2alpha isoform 2 AP-2alpha isoform 4 c-Jun AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITIH4 promoter sequence

Search SABiosciences Chromatin IP Primers for ITIH4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1

ITIH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH4 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M052846: view genomic region (about GC identifiers)

Start:	52,846,991 bp from pter	End:	52,865,495 bp from pter
Size:	18,505 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITIH4_HUMAN, Q14624 (See protein sequence)

Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H4 precursor

Size: 930 amino acids; 103357 Da

Subunit: Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage

by kallikrein in vitro

Subcellular location: Secreted

Miscellaneous: Possible biomarker for acute ischemic stroke (PubMed:19263524). Peptides derived from the proline-rich

potentially active peptide (PRO_0000016542) may be biomarkers for a variety of disease states including breast cancer

(PubMed:21137033)

Secondary accessions: B7Z545 E9PGN5 Q15135 Q9P190 Q9UQ54

Alternative splicing: 4 isoforms: Q14624-1 Q14624-2 Q14624-3 Q14624-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITIH4: NX_Q14624

Post-translational modifications:

Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further

converted to a 70 kDa fragment¹

N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725

consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated

but not O-glycosylated in plasma¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14624

ITIH4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001159921.1 NP_002209.2

ENSEMBL proteins:

ENSP00000266041 ENSP00000417824 ENSP00000384425 ENSP00000395634 ENSP00000340520

ENSP00000440036

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	Uscn Proteins for ITIH4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

ITIH4 for ontologies About GeneDecksing

ITIH4 Antibody Products:

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	Uscn ELISAs and CLIAs for ITIH4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITIH4 for domains About GeneDecksing

3 InterPro domains/families:

IPR010600 ITI_HC_C

IPR013694 VIT

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry Q14624

ProtoNet protein and cluster: Q14624

3 Blocks protein families:

IPB002035 Von Willebrand factor type A domain signature

IPB006587 Vault protein inter-alpha-trypsin

IPB010600 Inter-alpha-trypsin inhibitor heavy chain

UniProtKB/Swiss-Prot: ITIH4_HUMAN, Q14624

Similarity: Belongs to the ITIH family

Similarity: Contains 1 VIT domain

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITIH4_HUMAN, Q14624

Function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver

development or regeneration

Induction: Levels increase from 1.4 to 3-fold in acute-phase processes such as in acute ischemia stroke (AIS), unstable

angina and programmed surgery. In hepatocytes, induced by IL6 but not by other cytokines such as IL1B

Genatlas biochemistry entry for ITIH4:

trypsin inhibitor inter-alpha (protein HC),heavy chain 4

miRNA Products:		OriGene 3'-UTR Clone: ITIH4 Browse MicroRNA Expression Plasmids
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		hsa-miR-1323 hsa-miR-548o
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	TAS	9756925
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	16271702

ITIH4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Itih4^tm1Mish for ITIH4
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Itih4):

cellular

liver/biliary system

normal

tumorigenesis

ITIH4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITIH4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/6 Interacting proteins for ITIH4 (Q14624³ ENSP00000266041⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DNAJC1	Q96KC8³, ENSP00000366179⁴	I2D: score=1 STRING: ENSP00000366179
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007
LGALS3	P17931³	I2D: score=1
LGALS8	O00214³	I2D: score=1
LGALS9	O00182³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006953	acute-phase response	IEP	19263524
GO:0010951	negative regulation of endopeptidase activity	TAS	9756925
GO:0030212	hyaluronan metabolic process	IEA	--
GO:0034097	response to cytokine stimulus	IEP	10486281

ITIH4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITIH4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITIH4
10/97 Novoseek chemical compound relationships for ITIH4 gene (see all 97) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
c-d4i	87.2	23	12208966 (4), 12487827 (3), 15857992 (2), 12970440 (2) (see all 13)
galactosylceramide	76.8	52	8457384 (3), 7983725 (3), 8179824 (3), 7929093 (3) (see all 20)
ic9564	75.2	9	15207637 (5), 9343174 (1), 11120945 (1)
jm2763	72.9	1	8551604 (1)
enfuvirtide	72	11	15158765 (2), 10728472 (1), 15956589 (1), 16912327 (1) (see all 7)
cyanovirin	68.9	8	16912292 (3), 17348010 (2), 19235857 (1)
cg 10	68.1	4	15829299 (2), 14505910 (1), 17241712 (1)
bicyclam	67.9	2	8551604 (1), 9420029 (1)
siamycin i	64.7	1	8787894 (1)
dextran sulfate	62.4	11	1995952 (3), 8043225 (2), 1551875 (1), 10333239 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about ITIH4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITIH4 gene (2 alternative transcripts):

NM_001166449.1 NM_002218.4

Unigene Cluster for ITIH4:

Inter-alpha-trypsin inhibitor heavy chain family, member 4

Hs.709406 [show with all ESTs]

Unigene Representative Sequence: NM_002218

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000266041(uc011bem.2 uc003dfz.3) ENST00000485816 ENST00000406595

ENST00000464000 ENST00000441637 ENST00000491663 ENST00000461966 ENST00000481977

ENST00000537897 ENST00000471505 ENST00000484632 ENST00000485894 ENST00000467462

ENST00000483372 ENST00000473904(uc010hmp.1) ENST00000346281(uc011bel.2 uc003dfy.3 uc011ben.2)

ENST00000434759

miRNA Products:		OriGene 3'-UTR Clone: ITIH4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITIH4
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		hsa-miR-1323 hsa-miR-548o
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH4

Additional cDNA sequence:

AK298407.1 AK298412.1 AK298429.1 AK303769.1 BC136392.1 BC136393.1 BX647322.1 D38595.1

22 DOTS entries:

DT.95266302 DT.95266297 DT.102833207 DT.40280441 DT.100663232 DT.92439776 DT.95266298 DT.120911857

DT.454034 DT.92439783 DT.120911826 DT.214436 DT.91750171 DT.92439769 DT.100663417 DT.120911874

DT.95266300 DT.101956374 DT.102833208 DT.120911824 DT.120911838 DT.91673235

24/428 AceView cDNA sequences (see all 428):

BI963802 AV654981 AV653979 NM_002218 BM802543 AA723367 CR603484 AV647796

CB154334 BI966873 CR591457 AA346122 CB155974 CD614258 AI962765 CB161586

AL557947 CR614295 CR625639 BE909286 AV647813 CB163884 F27979 AV648742

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ITIH4 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^
SP1:																																													-						-
SP2:																			-		-																								-						-
SP3:																																													-						-
SP4:																																													-						-
SP5:

ExUns:	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21	^	22a	·	22b	·	22c	·	22d	·	22e	^	23	^	24a	·	24b	^	25a	·	25b	^	26
SP1:									-				-								-		-
SP2:			-		-		-		-				-								-		-		-		-		-
SP3:			-		-		-		-				-								-
SP4:									-
SP5:													-

ECgene alternative splicing isoforms for ITIH4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITIH4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGGAAGA

About this image

ITIH4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITIH4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITIH4

SOURCE GeneReport for Unigene cluster: Hs.709406

UniProtKB/Swiss-Prot: ITIH4_HUMAN, Q14624

Tissue specificity: Liver specific

SABiosciences Expression via Pathway-Focused PCR Array including ITIH4:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ITIH4 gene from 2/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ITIH4⁶	--	50(a)	1 ↔ 1	2(154999681-155031562)
zebrafish (Danio rerio)	Actinopterygii	wufb66b03²	Danio rerio cDNA clone MGC56244 IMAGE5601539, complete cds less	73.69(n)		BC050509.1

ENSEMBL Gene Tree for ITIH4 (if available)
TreeFam Gene Tree for ITIH4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITIH4 gene

ITIH5² ITIH1² ITIH3² ITIH2² ITIH6²

6 SIMAP similar genes for ITIH4 using alignment to 5 protein entries: ITIH4_HUMAN (see all proteins):

DKFZp686G21125 ITIH3 ITIH1 ITIH5 ITIH2 ITIH6

ITIH4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181754426^1,2		--	52846565(+)	`TCCTCA/CGGCCT`	2	--	ds500¹		0	--	--	--	--
rs144988670^1,2		--	52846653(+)	`TACAGG/TAATTG`	2	--	ds500¹		0	--	--	--	--
rs147141680^1,2		--	52846673(+)	`TTGGGA/GTGCCT`	2	--	ds500¹		0	--	--	--	--
rs146002144^1,2		--	52846701(+)	`AGGAA-/AGGAGACC`	2	--	ds500¹		0	--	--	--	--
rs186646752^1,2		--	52846804(+)	`GGCCTC/TGCCTC`	2	--	ds500¹		0	--	--	--	--
rs191952835^1,2		--	52847121(+)	`TGGTTC/GGAGCT`	2	--	ut3¹		0	--	--	--	--
rs117681659^1,2		--	52847230(+)	`TTCCAC/TGATGC`	2	--	ut3¹		1		EA	120
rs13326974^1,2	C,F,H,	--	52847415(+)	`GGGTGG/AGCACA`	2	--	ut3¹		9		NS EA NA WA	828
rs78780447^1,2	C,F,	--	52847473(+)	`ACTCCC/TGGGGG`	4	P	syn¹		3		NA EU	5996
rs140372968^1,2	C,F,	--	52847474(+)	`CTCCCG/AGGGGC`	4	/P /L	mis¹		1		NA	4552

HapMap Linkage Disequilibrium report for ITIH4 (52846991 - 52865495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ITIH4
1 CNV: 4339
Human Gene Mutation Database (HGMD): ITIH4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITIH4 for disorders           About GeneDecksing

OMIM gene information: 600564
OMIM disorders: 143890
20/42 diseases for ITIH4 (see all 42):    About MalaCards

aids dementia complex memory impairment connective tissue disease primary hyperoxaluria

prion disease acquired immunodeficiency syndrome gliosis encephalitis

diphtheria hypercholesterolemia urticaria peripheral neuropathy

tetanus neurodegenerative disease dementia stomatitis

herpes simplex scrapie hepatitis b rabies

10/57 Novoseek disease relationships for ITIH4 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	92.3	462	1549584 (3), 8620895 (3), 10799583 (2), 11711617 (2) (see all 99)
aids dementia complex	76.2	9	8558011 (1), 19634757 (1), 19100722 (1), 17505985 (1) (see all 8)
hiv infections	75	80	9295204 (4), 1706342 (3), 12775419 (3), 20088758 (2) (see all 61)
aids	70.4	65	15481145 (2), 7874383 (2), 2234433 (1), 9893752 (1) (see all 57)
hiv encephalitis	58.3	5	11125889 (2), 7856083 (1), 10665489 (1), 10482626 (1)
virus infection	50.9	21	10092648 (2), 15540608 (1), 18203956 (1), 18439274 (1) (see all 19)
dementia	48.5	20	11125889 (2), 2234433 (1), 10817620 (1), 11222997 (1) (see all 19)
aids-related complex	37.7	2	1671648 (1), 1867027 (1)
caprine arthritis-encephalitis	36	1	14592773 (1)
mimicry	34.8	7	9345046 (2), 7678970 (1), 8510178 (1), 18544021 (1) (see all 6)

Genetic Association Database (GAD): ITIH4
Human Genome Epidemiology (HuGE) Navigator: ITIH4 (2 documents)

Export disorders for ITIH4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITIH4 gene, integrated from 9 sources (see all 838):
(articles sorted by number of sources associating them with ITIH4)

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cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. (PubMed id 7805892)^{1, 2, 3} Nishimura H....Nagasawa S. (1995)
Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). (PubMed id 8797089)^{1, 2, 9} Saguchi K.... Tomita M. (1996)
Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. (PubMed id 7541790)^{1, 2, 9} Choi-Miura N.-H.... Tomita M. (1995)
SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain- related protein (IHRP) gene by a fluorescence-adapted SSCP method. (PubMed id 12147176)^{1, 2, 9} Tozaki T.... Tomita M. (2002)
Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. (PubMed id 7775381)^{1, 2, 9} Saguchi K....Tomita M. (1995)
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke. (PubMed id 19263524)^{1, 2} Kashyap R.S....Daginawala H.F. (2009)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. (PubMed id 16271702)^{1, 2} Kroczynska B....Blond S.Y. (2005)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{1, 2} Bunkenborg J.... Wisniewski J.R. (2004)
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. (PubMed id 14661079)^{1, 4} Fujita Y....Saito Y. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3700	HGNC: 6169	AceView: ITIH4andMGC52022andMUSTN1	Ensembl:ENSG00000055955	euGenes: HUgn3700
ECgene: ITIH4	H-InvDB: ITIH4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITIH4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ITIH4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITIH4 gene:
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