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Aliases for ITIH4 Gene

Aliases for ITIH4 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 4 2 3
  • ITIHL1 3 4 6
  • PK120 3 4 6
  • Inter-Alpha (Globulin) Inhibitor H4 (Plasma Kallikrein-Sensitive Glycoprotein) 2 3
  • Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein 3 4
  • Inter-Alpha-Inhibitor Heavy Chain 4 3 4
  • ITI Heavy Chain H4 3 4
  • ITI-HC4 3 4
  • PK-120 3 4
  • GP120 3 4
  • IHRP 3 4
  • Inter-Alpha-Trypsin Inhibitor, Heavy Chain-Like, 1 3
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 3
  • Plasma Kallikrein-Sensitive Glycoprotein 120 3
  • Plasma Kallikrein Sensitive Glycoprotein 120 4
  • Plasma Kallikrein-Sensitive Glycoprotein 2
  • H4P 3

External Ids for ITIH4 Gene

Previous Symbols for ITIH4 Gene

  • ITIHL1

Summaries for ITIH4 Gene

Entrez Gene Summary for ITIH4 Gene

  • The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for ITIH4 Gene

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain Family, Member 4) is a Protein Coding gene. Diseases associated with ITIH4 include aids dementia complex and hypercholesterolemia, familial. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

UniProtKB/Swiss-Prot for ITIH4 Gene

  • Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.

Gene Wiki entry for ITIH4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH4 Gene

Genomics for ITIH4 Gene

Genomic Location for ITIH4 Gene

52,812,975 bp from pter
52,831,479 bp from pter
18,505 bases
Minus strand

Genomic View for ITIH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITIH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH4 Gene

Proteins for ITIH4 Gene

  • Protein details for ITIH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H4
    Protein Accession:
    Secondary Accessions:
    • B7Z545
    • E9PGN5
    • Q15135
    • Q9P190
    • Q9UQ54

    Protein attributes for ITIH4 Gene

    930 amino acids
    Molecular mass:
    103357 Da
    Quaternary structure:
    • Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro.
    • Possible biomarker for acute ischemic stroke (PubMed:19263524). Peptides derived from the proline-rich potentially active peptide (PRO_0000016542) may be biomarkers for a variety of disease states including breast cancer (PubMed:21137033).

    Alternative splice isoforms for ITIH4 Gene


neXtProt entry for ITIH4 Gene

Proteomics data for ITIH4 Gene at MOPED

Post-translational modifications for ITIH4 Gene

  • Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment
  • N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn81, Asn207, Asn517, Asn577, and Thr720

Other Protein References for ITIH4 Gene

No data available for DME Specific Peptides for ITIH4 Gene

Domains for ITIH4 Gene


  • Contains 1 VIT domain.:
    • Q14624
  • Contains 1 VWFA domain.:
    • Q14624
  • Belongs to the ITIH family.:
    • Q14624
genes like me logo Genes that share domains with ITIH4: view

No data available for Gene Families for ITIH4 Gene

Function for ITIH4 Gene

Molecular function for ITIH4 Gene

GENATLAS Biochemistry: trypsin inhibitor inter-alpha (protein HC),heavy chain 4
UniProtKB/Swiss-Prot Function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
UniProtKB/Swiss-Prot Induction: Levels increase from 1.4 to 3-fold in acute-phase processes such as in acute ischemia stroke (AIS), unstable angina and programmed surgery. In hepatocytes, induced by IL6 but not by other cytokines such as IL1B.

Gene Ontology (GO) - Molecular Function for ITIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 9756925
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 16271702
genes like me logo Genes that share ontologies with ITIH4: view
genes like me logo Genes that share phenotypes with ITIH4: view

Animal Models for ITIH4 Gene

MGI Knock Outs for ITIH4:

miRNA for ITIH4 Gene

miRTarBase miRNAs that target ITIH4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITIH4 Gene

Localization for ITIH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH4 Gene


Subcellular locations from

Jensen Localization Image for ITIH4 Gene COMPARTMENTS Subcellular localization image for ITIH4 gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ITIH4: view

Pathways for ITIH4 Gene

SuperPathways for ITIH4 Gene

No Data Available

Interacting Proteins for ITIH4 Gene

Gene Ontology (GO) - Biological Process for ITIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEP 19263524
GO:0010951 negative regulation of endopeptidase activity TAS 9756925
GO:0030212 hyaluronan metabolic process IEA --
GO:0034097 response to cytokine IEP 10486281
genes like me logo Genes that share ontologies with ITIH4: view

No data available for Pathways by source for ITIH4 Gene

Compounds for ITIH4 Gene

(97) Novoseek inferred chemical compound relationships for ITIH4 Gene

Compound -log(P) Hits PubMed IDs
c-d4i 87.2 20
galactosylceramide 76.8 32
ic9564 75.2 7
jm2763 72.9 1
enfuvirtide 72 8
genes like me logo Genes that share compounds with ITIH4: view

Transcripts for ITIH4 Gene

Unigene Clusters for ITIH4 Gene

Inter-alpha-trypsin inhibitor heavy chain family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP11: - -
SP12: -

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c · 22d · 22e ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6: - - - - - -
SP9: - -

Relevant External Links for ITIH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITIH4 Gene

mRNA expression in normal human tissues for ITIH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITIH4 Gene

SOURCE GeneReport for Unigene cluster for ITIH4 Gene Hs.709406

mRNA Expression by UniProt/SwissProt for ITIH4 Gene

Tissue specificity: Liver specific.
genes like me logo Genes that share expressions with ITIH4: view

Orthologs for ITIH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITIH4 36
  • 99.26 (n)
  • 98.78 (a)
ITIH4 37
  • 98 (a)
(Bos Taurus)
Mammalia ITIH4 36
  • 80.29 (n)
  • 73.94 (a)
ITIH4 37
  • 73 (a)
(Canis familiaris)
Mammalia ITIH4 36
  • 81.29 (n)
  • 75.37 (a)
ITIH4 37
  • 70 (a)
(Mus musculus)
Mammalia Itih4 36
  • 74.72 (n)
  • 69.35 (a)
Itih4 16
Itih4 37
  • 65 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 54 (a)
-- 37
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia ITIH4 37
  • 52 (a)
(Rattus norvegicus)
Mammalia Itih4 36
  • 73.83 (n)
  • 68.87 (a)
(Anolis carolinensis)
Reptilia ITIH4 37
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487172 36
  • 56.47 (n)
  • 51.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8594 36
(Danio rerio)
Actinopterygii ITIH4 37
  • 50 (a)
wufb66b03 36
zgc:112265 36
  • 52.1 (n)
  • 45.38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1308 36
Species with no ortholog for ITIH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH4 Gene

Gene Tree for ITIH4 (if available)
Gene Tree for ITIH4 (if available)

Paralogs for ITIH4 Gene

Paralogs for ITIH4 Gene

Selected SIMAP similar genes for ITIH4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ITIH4: view

Variants for ITIH4 Gene

Sequence variations from dbSNP and Humsavar for ITIH4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1050042 -- 52,829,181(-) AATAC(G/T)GTACA synonymous-codon, reference
rs1052728 -- 52,820,456(-) CCCCA(A/G)ATTCA intron-variant
rs1052729 -- 52,820,455(-) CCCAA(A/T)TTCAT intron-variant
rs1130868 -- 52,827,108(-) AAAGA(A/G)CGCTG missense, reference
rs1130869 -- 52,820,770(-) TCCGA(C/T)GCTGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ITIH4 Gene

Variant ID Type Subtype PubMed ID
nsv834698 CNV Gain 17160897
nsv508928 CNV Insertion 20534489
nsv876797 CNV Loss 21882294
nsv3822 CNV Insertion 18451855
nsv876798 CNV Loss 21882294

Relevant External Links for ITIH4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ITIH4 Gene

(1) OMIM Diseases for ITIH4 Gene (600564)

(57) Novoseek inferred disease relationships for ITIH4 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 92.3 142
aids dementia complex 76.2 8
hiv infections 75 73
aids 70.4 59
hiv encephalitis 58.3 5

Relevant External Links for ITIH4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ITIH4: view

No data available for UniProtKB/Swiss-Prot for ITIH4 Gene

Publications for ITIH4 Gene

  1. Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. (PMID: 7775381) Saguchi K. … Tomita M. (J. Biochem. 1995) 3 4 23
  2. Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). (PMID: 8797089) Saguchi K. … Tomita M. (J. Biochem. 1996) 3 4 23
  3. SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain- related protein (IHRP) gene by a fluorescence-adapted SSCP method. (PMID: 12147176) Tozaki T. … Tomita M. (BMC Med. Genet. 2002) 3 4 23
  4. Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. (PMID: 7541790) Choi-Miura N.-H. … Tomita M. (J. Biochem. 1995) 3 4 23
  5. cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. (PMID: 7805892) Nishimura H. … Nagasawa S. (FEBS Lett. 1995) 2 3 4

Products for ITIH4 Gene

Sources for ITIH4 Gene

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