ITIH3 Gene
protein-coding GIFtS: 57
GCID: GC03P052803
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inter-alpha-trypsin inhibitor heavy chain 3(Previous names: inter-alpha (globulin) inhibitor, H3 polypeptide, inter-alpha...)
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Aliases
for ITIH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inter-Alpha-Trypsin Inhibitor Heavy Chain 31 2 | | ITI-HC32 3 | | H3P1 2 | | SHAP2 3 | | Inter-Alpha (Globulin) Inhibitor H31 2 | | ITI Heavy Chain H32 3 | | Inter-Alpha (Globulin) Inhibitor, H3 Polypeptide1 2 | | Inter-Alpha-Trypsin Inhibitor Heavy Chain H32 | | Inter-Alpha-Inhibitor Heavy Chain 32 3 | | Pre-Alpha (Globulin) Inhibitor, H3 Polypeptide2 | | Serum-Derived Hyaluronan-Associated Protein2 3 | | |
Export aliases for ITIH3 gene to outside databasesPrevious GC identifers: GC03P051920 GC03P052080 GC03P052683 GC03P052786 |
Summaries
for ITIH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ITIH3:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitorsinvolved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multipleproteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 (PubMed2446322); Himmelfarb et al., 2004 (PubMed 14744536)).(supplied by OMIM, Nov 2009)
UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrixprotein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation ofhyaluronan which are essential to cells undergoing biological processes
Gene Wiki entry for ITIH3
|
Genomic Views
for ITIH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ITIH3 gene promoter:
GR Egr-3 Pax-5 Pax-2 MIF-1 Pax-2a NF-E2 p45 ARP-1 GR-alpha NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ITIH3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1ITIH3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P052803: view genomic region
(about GC identifiers)
Start:
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52,828,784 bp from pter |
End:
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52,843,025 bp from pter |
Size:
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14,242 bases |
Orientation:
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plus strand |
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Proteins
for ITIH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033 (See
protein sequence)Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H3 precursor Size: 890 amino acids; 99849 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one lightchain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor(I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Subcellular location: Secreted
Sequence caution: Sequence=CAA32821.1; Type=Frameshift; Positions=732, 736, 739; Sequence=CAA47439.1; Type=Frameshift;Positions=21, 732, 736, 739;
Secondary accessions: Q3B7H5 Q53F06 Q6LAM2 Q99085Alternative splicing: 2 isoforms: Q06033-1 Q06033-2 Explore the universe of human proteins at neXtProt for ITIH3: NX_Q06033
Post-translational modifications:
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminalaspartate after propeptide cleavage1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q06033
ITIH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002208.3
ENSEMBL proteins: ENSP00000413922 ENSP00000415769
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ITIH3 for ontologies About GeneDecksing
ITIH3 Antibody Products:
Assay Products for ITIH3: |
Protein
Domains /
Families
for ITIH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ITIH3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q06033ProtoNet protein and cluster: Q06033 3 Blocks protein families: IPB002035 Von Willebrand factor type A domain signature IPB006587 Vault protein inter-alpha-trypsin IPB010600 Inter-alpha-trypsin inhibitor heavy chain
UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033Similarity: Belongs to the ITIH familySimilarity: Contains 1 VIT domainSimilarity: Contains 1 VWFA domain |
Function
for ITIH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrixprotein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation ofhyaluronan which are essential to cells undergoing biological processes Genatlas biochemistry entry for ITIH3:trypsin inhibitor,inter-alpha- (protein HC),heavy chain 3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ITIH3 (NM_002217) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITIH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004866 | endopeptidase inhibitor activity |
TAS | 2465147 | | GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
ITIH3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ITIH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Cell-matrix glycoconjugates | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ITIH3
1  GeneGo (Thomson Reuters) Pathway for ITIH3
ITIH3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITIH3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ITIH3 (Q060333 ENSP000004157694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010951 | negative regulation of endopeptidase activity |
TAS | 2465147 | | GO:0030212 | hyaluronan metabolic process |
IEA | -- |
ITIH3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ITIH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ITIH3
Search CenterWatch for drugs/clinical trials and news about ITIH3
|
Transcripts
for ITIH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ITIH3 gene: NM_002217.3 Unigene Cluster for ITIH3: Inter-alpha-trypsin inhibitor heavy chain 3 Hs.76716 [show with all ESTs]Unigene Representative Sequence: NM_00221710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467268 ENST00000416872 ENST00000449956(uc003dfv.2 uc011bek.1)
ENST00000465243 ENST00000463893 ENST00000464804 ENST00000465314 ENST00000475931
ENST00000495622 ENST00000493136
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ITIH3 (NM_002217) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITIH3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH3 |
Additional cDNA sequence: AK222757.1 AK223483.1 AK298450.1 BC107604.1 BC107605.1 BC107814.1 X14690.1 X67055.1 10 DOTS entries: DT.414032 DT.120877988 DT.92422154 DT.101977794 DT.100766592 DT.100781218 DT.120877996 DT.97807212 DT.417972 DT.75166070 24/85 AceView cDNA sequences (see all 85): BX449126 AU076616 BM682153 AA776325 AV662140 BE049487 R29745 AK122858 AI810685 BG618930 T68698 NM_002217 BX463119 BF509521 BX494707 BX463118 AI804742 BX433343 BP343216 BX427074 BX405447 AI683095 BX495022 CD614252
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ITIH3 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ITIH3
|
Expression
for ITIH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ITIH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCACAGAGA
About this image
See ITIH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITIH3
SOURCE GeneReport for Unigene cluster: Hs.76716
SABiosciences Custom PCR Arrays for ITIH3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITIH3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITIH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITIH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH3 |
Orthologs
for ITIH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ITIH3 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ITIH31 |
inter-alpha-trypsin inhibitor heavy chain 3 |
65.82(n)
65.82(a) |
|
415901 XM_414253.3 XP_414253.3 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
62(a)61(a) |
1 ↔ many1 ↔ many |
2(154967773-154991314) 2(154938954-154963400) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.50402 |
Xenopus laevis transcribed sequence with weak similarity more |
76.63(n) |
|
BX850414.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC056811.12 |
-- |
72.99(n) |
|
BC056811.1 |
ENSEMBL Gene Tree for ITIH3 (if available)
TreeFam Gene Tree for ITIH3 (if available) |
Paralogs
for ITIH3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ITIH3 gene
- ITIH52 ITIH12 ITIH22 ITIH42 ITIH62
6 SIMAP similar genes for ITIH3 using alignment to 2 protein entries: ITIH3_HUMAN (see all proteins):DKFZp686G21125 ITIH4 ITIH1 ITIH5 ITIH6 ITIH2
ITIH3 for paralogs About GeneDecksing
|
Genomic Variants
for ITIH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ITIH3 (52828784 - 52843025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ITIH3
1 CNV: 4339
Human Gene Mutation Database (HGMD): ITIH3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITIH3 |
|
Disorders
/ Diseases
for ITIH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ITIH3 for disorders About GeneDecksing
OMIM gene information: 146650
OMIM disorders: --
3  diseases for ITIH3: About MalaCardsmyocardial infarction gastric cancer breast cancer
Human Genome Epidemiology (HuGE) Navigator: ITIH3 (2 documents)
Export disorders for ITIH3 gene to outside databases
|
Publications
for ITIH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ITIH3 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with ITIH3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. (PubMed id 2465147)1, 2, 3 Diarra-Mehrpour M.... Martin J.-P. (1989)
- Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. (PubMed id 9756925)1, 2, 9 Diarra-Mehrpour M....Martin J.-P. (1998)
- Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. (PubMed id 7522574)1, 2, 9 Diarra-Mehrpour M.... Martin J.-P. (1994)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.P. (1999)
- Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. (PubMed id 7681778)1, 2 Bourguignon J.... Martin J.-P. (1993)
- Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. (PubMed id 1898736)1, 2 Enghild J.J....Pizzo S.V. (1991)
- Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. (PubMed id 2476436)1, 2 Enghild J.J.... Salvesen G. (1989)
- A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction. (PubMed id 17211523)1, 9 Ebana Y....Tanaka T. (2007)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
|
External Searches for ITIH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ITIH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ITIH3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ITIH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ITIH3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ITIH3 gene:
Search GeneIP for patents involving ITIH3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ITIH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ITIH3 | | OriGene shRNA RFP for ITIH3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITIH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITIH3 | | | OriGene Protein Over-expression Lysate for ITIH3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ITIH3 | | OriGene 3'-UTR Clone for ITIH3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ITIH3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ITIH3 | | OriGene Custom Protein Services for ITIH3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITIH3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITIH3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITIH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITIH3 |
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 | | | ITIH3 Proteins, Antibodies, CLIAs, and ELISAs |
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