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ITIH3 Gene

protein-coding   GIFtS: 59
GCID: GC03P052828

Inter-Alpha-Trypsin Inhibitor Heavy Chain 3

(Previous names: inter-alpha (globulin) inhibitor, H3 polypeptide, inter-alpha...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain 31 2     SHAP2 3
Inter-Alpha (Globulin) Inhibitor H31 2     ITI Heavy Chain H32 3
Inter-Alpha (Globulin) Inhibitor, H3 Polypeptide1 2     H3 Polypeptide1
Inter-Alpha-Trypsin Inhibitor Heavy Chain H31 2     Pre-Alpha (Globulin) Inhibitor1
Inter-Alpha-Inhibitor Heavy Chain 32 3     H3P2
Serum-Derived Hyaluronan-Associated Protein2 3     Pre-Alpha (Globulin) Inhibitor, H3 Polypeptide2
ITI-HC32 3     

External Ids:    HGNC: 61681   Entrez Gene: 36992   Ensembl: ENSG000001622677   OMIM: 1466505   UniProtKB: Q060333   

Export aliases for ITIH3 gene to outside databases

Previous GC identifers: GC03P051920 GC03P052080 GC03P052683 GC03P052786 GC03P052803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITIH3 Gene:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors
involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains
multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al.,
1987 (PubMed 2446322); Himmelfarb et al., 2004 (PubMed 14744536)).(supplied by OMIM, Nov 2009)

GeneCards Summary for ITIH3 Gene:
ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3) is a protein-coding gene. Diseases associated with ITIH3 include smallpox, and myocardial infarction. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH5.

UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
hyaluronan which are essential to cells undergoing biological processes

Gene Wiki entry for ITIH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITIH3 gene promoter:
         GR   Egr-3   Pax-5   Pax-2   MIF-1   Pax-2a   NF-E2 p45   ARP-1   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITIH3 promoter sequence
   Search Chromatin IP Primers for ITIH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITIH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

ITIH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052828:  view genomic region     (about GC identifiers)

Start:
52,828,784 bp from pter      End:
52,843,025 bp from pter
Size:
14,242 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H3 precursor  
Size: 890 amino acids; 99849 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one
light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like
inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Sequence caution: Sequence=CAA32821.1; Type=Frameshift; Positions=732, 736, 739; Sequence=CAA47439.1;
Type=Frameshift; Positions=21, 732, 736, 739;
Secondary accessions: Q3B7H5 Q53F06 Q6LAM2 Q99085
Alternative splicing: 2 isoforms:  Q06033-1   Q06033-2   

Explore the universe of human proteins at neXtProt for ITIH3: NX_Q06033

Explore proteomics data for ITIH3 at MOPED

Post-translational modifications: 

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal
    aspartate after propeptide cleavage1
  • Glycosylation2 at Asn91, Asn580
  • Modification sites at PhosphoSitePlus

  • See ITIH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002208.3  
    ENSEMBL proteins: 
     ENSP00000413922   ENSP00000415769  

    ITIH3 Human Recombinant Protein Products:

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    ITIH3 Antibody Products:

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    ITIH3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ITIH3
    Cloud-Clone Corp. CLIAs for ITIH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013694 VIT
     IPR010600 ITI_HC_C
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q06033

    ProtoNet protein and cluster: Q06033

    3 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB006587 Vault protein inter-alpha-trypsin
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH3_HUMAN, Q06033
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    ITIH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITIH3_HUMAN, Q06033
    Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
    hyaluronan which are essential to cells undergoing biological processes

         Genatlas biochemistry entry for ITIH3:
    trypsin inhibitor,inter-alpha- (protein HC),heavy chain 3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS2465147
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    ITIH3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITIH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITIH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITIH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITIH3

    miRNA
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    Block miRNA regulation of human, mouse, rat ITIH3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ITIH3:
    hsa-miR-485-5p hsa-miR-4297 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidITIH3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITIH3
    Predesigned siRNA for gene silencing in human, mouse, rat ITIH3

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITIH3 (NM_002217)
    Sino Biological Human cDNA Clone for ITIH3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITIH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITIH3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITIH3_HUMAN, Q06033: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574

    ITIH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITIH3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ITIH3
        Cell adhesion Cell-matrix glycoconjugates



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITIH3
    Interactions:

        Search GeneGlobe Interaction Network for ITIH3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ITIH3 (Q060333 ENSP000004157694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINT2O432913, ENSP000003012444I2D: score=1 STRING: ENSP00000301244
    EP300ENSP000002632534STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity TAS2465147
    GO:0030212hyaluronan metabolic process IEA--

    ITIH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITIH3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITIH3 gene: 
    NM_002217.3  

    Unigene Cluster for ITIH3:

    Inter-alpha-trypsin inhibitor heavy chain 3
    Hs.76716  [show with all ESTs]
    Unigene Representative Sequence: NM_002217
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467268 ENST00000416872 ENST00000449956(uc003dfv.2 uc011bek.1)
    ENST00000465243 ENST00000463893 ENST00000464804 ENST00000465314 ENST00000475931
    ENST00000495622 ENST00000493136
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITIH3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ITIH3:
    hsa-miR-485-5p hsa-miR-4297 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidITIH3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITIH3
    Predesigned siRNA for gene silencing in human, mouse, rat ITIH3
    Clone
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    OriGene ORF clones in mouse, rat for ITIH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITIH3 (NM_002217)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITIH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITIH3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITIH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITIH3
      QuantiTect SYBR Green Assays in human, mouse, rat ITIH3
      QuantiFast Probe-based Assays in human, mouse, rat ITIH3

    Additional mRNA sequence: 

    AK222757.1 AK223483.1 AK298450.1 BC107604.1 BC107605.1 BC107814.1 X14690.1 X67055.1 

    10 DOTS entries:

    DT.414032  DT.120877988  DT.92422154  DT.101977794  DT.100766592  DT.100781218  DT.120877996  DT.97807212 
    DT.417972  DT.75166070 

    Selected AceView cDNA sequences (see all 85):

    R29745 BX449126 AA776325 AU076616 AK122858 BE049487 AV662140 BM682153 
    BM804713 BX449127 BQ004649 BX097063 BX433343 AI810685 BG618930 BF509521 
    T68698 T71065 AI972055 BX463118 CD614252 AI349397 BX448165 BX495022 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITIH3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                                            -                 -                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                        -                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ITIH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITIH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACAGAGA
    ITIH3 Expression
    About this image

    ITIH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITIH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76716
        Custom PCR Arrays for ITIH3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itih31 , 5 inter-alpha trypsin inhibitor, heavy chain 31, 5 84.68(n)1
    85.14(a)1
      14 (19.09 cM)5
    164261  NM_008407.21  NP_032433.21 
     309085735 
    chicken
    (Gallus gallus)
    Aves ITIH31 inter-alpha-trypsin inhibitor heavy chain 3 66.31(n)
    66.35(a)
      415901  XM_414253.4  XP_414253.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    60(a)
    many ↔ many
    many ↔ many
    2(154965390-154997505)
    2(154929165-154963400)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50402 Xenopus laevis transcribed sequence with weak similarity more 76.63(n)    BX850414.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056811.12   -- 72.99(n)    BC056811.1 


    ENSEMBL Gene Tree for ITIH3 (if available)
    TreeFam Gene Tree for ITIH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITIH3 gene
    ITIH52  ITIH12  ITIH22  ITIH42  ITIH62  
    6 SIMAP similar genes for ITIH3 using alignment to 2 protein entries:     ITIH3_HUMAN (see all proteins):
    DKFZp686G21125    ITIH4    ITIH1    ITIH5    ITIH6    ITIH2

    ITIH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITIH3 (see all 486)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20715081,2
    C,F,O,A,H--52826846(+) ATGACG/AACTCT 1 -- us2k130Minor allele frequency- A:0.40EA NS NA WA CSA 3784
    rs1807935111,2
    --52826923(+) TGTCCA/GTCTCC 1 -- us2k10--------
    rs1144591911,2
    C,F--52827021(+) GGAGCC/TATTGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1859749451,2
    --52827026(+) CATTGA/GGCAAC 1 -- us2k10--------
    rs1408662251,2
    C--52827099(+) GGACAC/TGGCAG 1 -- us2k10--------
    rs1501761161,2
    C--52827172(+) CCCGAG/TCTTGG 1 -- us2k10--------
    rs1908464401,2
    --52827227(+) GGGAAA/CCAGGC 1 -- us2k10--------
    rs1831119761,2
    --52827336(+) GAGACG/TGGGGT 1 -- us2k10--------
    rs729622171,2
    C--52827384(+) ACACAG/ACGCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1385178121,2
    --52827401(+) GCCTCA/GAACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITIH3 (52828784 - 52843025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ITIH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508928CNV Insertion20534489
    nsv3822CNV Insertion18451855
    nsv876797CNV Loss21882294
    nsv834698CNV Gain17160897

    Human Gene Mutation Database (HGMD): ITIH3
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146650    OMIM disorders: --

    5 diseases for ITIH3:    About MalaCards
    smallpox    myocardial infarction    bipolar disorder    schizophrenia
    breast cancer


    ITIH3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ITIH3
    Human Genome Epidemiology (HuGE) Navigator: ITIH3 (2 documents)

    Export disorders for ITIH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITIH3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ITIH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. (PubMed id 2465147)1, 2, 3 Diarra-Mehrpour M.... Martin J.-P. (Eur. J. Biochem. 1989)
    2. Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. (PubMed id 9756925)1, 2, 9 Diarra-Mehrpour M....Martin J.-P. (J. Biol. Chem. 1998)
    3. A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction. (PubMed id 17211523)1, 4, 9 Ebana Y....Tanaka T. (J. Hum. Genet. 2007)
    4. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. (PubMed id 7522574)1, 2, 9 Diarra-Mehrpour M.... Martin J.-P. (Biochim. Biophys. Acta 1994)
    5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1, 4 (Nat. Genet. 2011)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha- inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.-P. (FEBS Lett. 1999)
    8. Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. (PubMed id 7681778)1, 2 Bourguignon J.... Martin J.-P. (Eur. J. Biochem. 1993)
    9. Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. (PubMed id 1898736)1, 2 Enghild J.J....Pizzo S.V. (J. Biol. Chem. 1991)
    10. Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. (PubMed id 2476436)1, 2 Enghild J.J.... Salvesen G. (J. Biol. Chem. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3699 HGNC: 6168 AceView: ITIH3 Ensembl:ENSG00000162267 euGenes: HUgn3699
    ECgene: ITIH3 H-InvDB: ITIH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITIH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITIH3 gene:
    Search GeneIP for patents involving ITIH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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