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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITIH2 Gene

protein-coding   GIFtS: 56
GCID: GC10P007785

inter-alpha-trypsin inhibitor heavy chain 2

(Previous names: inter-alpha (globulin) inhibitor, H2 polypeptide )
 Explore 7 diseases affiliated with
ITIH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITIH2    

Aliases
for ITIH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain 21 2     ITI-HC22 3
H2P1 2     SHAP2 3
Inter-Alpha (Globulin) Inhibitor, H2 Polypeptide1 2     ITI Heavy Chain H22 3
Inter-Alpha-Inhibitor Heavy Chain 22 3     Inter-Alpha (Globulin) Inhibitor H22
Inter-Alpha-Trypsin Inhibitor Complex Component II2 3     Inter-Alpha-Trypsin Inhibitor Heavy Chain H22
Serum-Derived Hyaluronan-Associated Protein2 3     IGHEP23

External Ids:    HGNC: 61671   Entrez Gene: 36982   Ensembl: ENSG000001516557   OMIM: 1466405   UniProtKB: P198233   

Export aliases for ITIH2 gene to outside databases

Previous GC identifers: GC10P007689 GC10P007895 GC10P007749


Summaries
for ITIH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITIH2:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors
involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple
proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 (PubMed
2446322); Himmelfarb et al., 2004 (PubMed 14744536)).(supplied by OMIM, Nov 2009)

UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
hyaluronan which are essential to cells undergoing biological processes

Gene Wiki entry for ITIH2


Genomic Views
for ITIH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITIH2 gene promoter:
         HFH-3   Olf-1   MyoD   STAT5A   MZF-1   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITIH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITIH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p14

ITIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P007785:  view genomic region     (about GC identifiers)

Start:
 7,745,232 bp from pter      End:
 7,791,483 bp from pter
Size:
 46,252 bases      Orientation:
 plus strand

Proteins
for ITIH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H2 precursor  
Size: 946 amino acids; 106463 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light
chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor
(I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Subcellular location: Secreted
Mass spectrometry: Mass=76508; Method=MALDI; Range=55-702; Source=PubMed:9677337;
Sequence caution: Sequence=CAA30160.1; Type=Frameshift; Positions=363, 373;
Secondary accessions: Q14659 Q15484 Q5T986

Explore the universe of human proteins at neXtProt for ITIH2: NX_P19823

Post-translational modifications:

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal
    • aspartate after propeptide cleavage (By similarity)1
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Phosphorylation sites are present in the extracellular medium1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19823

    • ITIH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002207.2  
    ENSEMBL proteins: 
     ENSP00000351190   ENSP00000388826   ENSP00000368906  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ITIH2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574


    ITIH2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ITIH2

    Protein Domains /
    Families
    for ITIH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITIH2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR010600 ITI_HC_C
     IPR013694 VIT
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P19823

    ProtoNet protein and cluster: P19823

    3 Blocks protein families:
    IPB002035 Von Willebrand factor type A domain signature
    IPB006587 Vault protein inter-alpha-trypsin
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    Function
    for ITIH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
    Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
    hyaluronan which are essential to cells undergoing biological processes

         Genatlas biochemistry entry for ITIH2:
    trypsin inhibitor,inter-alpha- (protein HC),heavy chain 2

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITIH2 (see all 4)
    OriGene shRNA RFP: ITIH2
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITIH2 (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ITIH2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS2476436
    GO:0004867serine-type endopeptidase inhibitor activity IEA--


    ITIH2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ITIH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Cell-matrix glycoconjugates
    		Cell adhesion_Cell-matrix glycoconjugates1.00
    		Cell adhesion Cell-matrix glycoconjugates0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ITIH2
        Cell adhesion Cell-matrix glycoconjugates


    1 GeneGo (Thomson Reuters) Pathway for ITIH2
        Cell adhesion Cell-matrix glycoconjugates



    ITIH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITIH2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ITIH2 (P198232, 3 ENSP000003511904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5C1P365422, 3, ENSP000003491424MINT-63706 I2D: score=5 STRING: ENSP00000349142
    FCER1AP123193I2D: score=1 
    SPINT2O432913I2D: score=1 
    --ENSP000003969204STRING: ENSP00000396920
    --ENSP000003157194STRING: ENSP00000315719
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity TAS2476436
    GO:0030212hyaluronan metabolic process IEA--


    ITIH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITIH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITIH2
    Search CenterWatch for drugs/clinical trials and news about ITIH2 

    Transcripts
    for ITIH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITIH2 gene: 
    NM_002216.2  

    Unigene Cluster for ITIH2:

    Inter-alpha-trypsin inhibitor heavy chain 2
    Hs.75285  [show with all ESTs]
    Unigene Representative Sequence: NM_002216
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358415(uc001ijs.3) ENST00000476165 ENST00000473227 ENST00000480387
    ENST00000429820 ENST00000379587 ENST00000477751

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ITIH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITIH2 (see all 4)
    OriGene shRNA RFP: ITIH2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK225277.1 AK225329.1 AK291379.1 AK297334.1 BC132685.1 M18193.1 M33033.1 X07173.1 

    12 DOTS entries:

    DT.91773739  DT.91773742  DT.91773717  DT.121283125  DT.91773741  DT.92052622  DT.95196601  DT.95262128 
    DT.95262129  DT.95262130  DT.95262134  DT.75193146 

    24/133 AceView cDNA sequences (see all 133):

    CB154197 AL557835 T61669 CB154176 CB162003 CB162091 AI052079 CR624216 
    CB154170 AV660445 T28559 BX112392 T17086 AA974767 AV658595 CB163313 
    AV660400 F05319 F12378 AA406494 AI114825 R95707 AA705166 M18193 

    GeneLoc Exon Structure


    Expression
    for ITIH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITIH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGTGAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITIH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See ITIH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITIH2

    SOURCE GeneReport for Unigene cluster: Hs.75285

    UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
    Tissue specificity: Plasma

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    In Situ
    Assay Products:     
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    Orthologs
    for ITIH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Itih21 , 5 inter-alpha trypsin inhibitor, heavy chain 21, 5 82.52(n)1
    83.93(a)1    		   2 (6.89 cM)5
    164251  NM_010582.31  NP_034712.21 
     100945935 
    chicken
    (Gallus gallus)    		 Aves ITIH21 inter-alpha (globulin) inhibitor H2 69.01(n)
    66.67(a)    		   419110  NM_001130741.1  NP_001124213.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ITIH26
    		 --
    		 65(a)
    		 1 ↔ 1
    		 5(204250-229854)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.50992 Xenopus laevis transcribed sequence with weak similarity more 80.11(n)    48038751 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.8522 Danio rerio mRNA similar to inter-alpha trypsin inhibitor, more 71.98(n)    BC045924.1 


    ENSEMBL Gene Tree for ITIH2 (if available)
    TreeFam Gene Tree for ITIH2 (if available) 

    Paralogs
    for ITIH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITIH2 gene
    ITIH52  ITIH12  ITIH32  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH2 using alignment to 5 protein entries:     ITIH2_HUMAN (see all proteins):
    ITIH1    DKFZp686G21125    ITIH5    ITIH3    ITIH4

    ITIH2 for paralogs           About GeneDecksing



    Genomic Variants
    for ITIH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1162 NCBI SNPs in ITIH2 are shown (see all 1162)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1131045631,2
    		--7743347(+) CGCCCG/ATAATT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs736212351,2
    		C,--7743352(+) GTAATT/CCCAGC 1 -- us2k12Minor allele frequency- C:0.08CSA NA 122
    rs1147033221,2
    		F,--7743377(+) AGGCAG/AGGGAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs23883211,2
    		C,A,--7743387(+) ATCGCG/TTGAAC 1 -- us2k14Minor allele frequency- T:0.09NA CSA 124
    rs23883221,2
    		C,F,--7743408(+) GAGGTG/TGCAGT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs112552951,2
    		--7743409(+) aggttA/Gcagta 1 -- us2k10--------
    rs1408012691,2
    		--7743459(+) AGTGAC/TGCTCC 1 -- us2k10--------
    rs357867901,2
    		C--7743470(+) AAAAA-/AGGACT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1848490551,2
    		--7743657(+) ACATGC/TCATTG 1 -- us2k10--------
    rs19808601,2
    		C,F,A,H,--7743666(-) TAAAAA/GACCCA 1 -- us2k1 tfbs312Minor allele frequency- G:0.31NS EA WA NA CSA 628

    HapMap Linkage Disequilibrium report for ITIH2 (7745232 - 7791483 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ITIH2
         1 CNV: 100850

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    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITIH2
    DNA2.0 Custom Variant and Variant Library Synthesis for ITIH2

    Disorders / Diseases
    for ITIH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITIH2 for disorders           About GeneDecksing

    OMIM gene information: 146640    OMIM disorders: --

    7 diseases for ITIH2:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    alzheimer's disease    ovarian cancer
    breast cancer    cervicitis    arthritis

    Human Genome Epidemiology (HuGE) Navigator: ITIH2 (1 document)

    Export disorders for ITIH2 gene to outside databases

    Publications
    for ITIH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITIH2 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with ITIH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. (PubMed id 7504674)1, 2, 9 Huang L.... Kimata K. (1993)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    4. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.P. (1999)
    5. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. (PubMed id 9425062)1, 2 Olsen E.H.N....Enghild J.J. (1998)
    6. Glycosylation pattern of human inter-alpha-inhibitor heavy chains. (PubMed id 9677337)1, 2 Flahaut C.... Mizon J. (1998)
    7. Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. (PubMed id 7513643)1, 2 Morelle W.... Mizon J. (1994)
    8. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. (PubMed id 7516184)1, 2 Wisniewski H.-G.... Vilcek J. (1994)
    9. Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. (PubMed id 7682553)1, 2 Enghild J.J....Hefta S.A. (1993)
    10. Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. (PubMed id 1385302)1, 3 Salier J.P....Mattei M.G. (1992)

    External Searches for ITIH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ITIH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3698 HGNC: 6167 AceView: ITIH2 Ensembl:ENSG00000151655 euGenes: HUgn3698
    ECgene: ITIH2 H-InvDB: ITIH2

    Other Databases showing ITIH2 gene

    (According to HUGE)
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    Specialized Databases showing ITIH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITIH2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ITIH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for ITIH2 gene:
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