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ITIH2 Gene

protein-coding   GIFtS: 60
GCID: GC10P007785

Inter-Alpha-Trypsin Inhibitor Heavy Chain 2

(Previous names: inter-alpha (globulin) inhibitor, H2 polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain 21 2     SHAP2 3
Inter-Alpha (Globulin) Inhibitor, H2 Polypeptide1 2     ITI Heavy Chain H22 3
Inter-Alpha-Inhibitor Heavy Chain 22 3     H2P2
Inter-Alpha-Trypsin Inhibitor Complex Component II2 3     Inter-Alpha (Globulin) Inhibitor H22
Serum-Derived Hyaluronan-Associated Protein2 3     Inter-Alpha-Trypsin Inhibitor Heavy Chain H22
ITI-HC22 3     IGHEP23

External Ids:    HGNC: 61671   Entrez Gene: 36982   Ensembl: ENSG000001516557   OMIM: 1466405   UniProtKB: P198233   

Export aliases for ITIH2 gene to outside databases

Previous GC identifers: GC10P007689 GC10P007895 GC10P007749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITIH2 Gene:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors
involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains
multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al.,
1987 (PubMed 2446322); Himmelfarb et al., 2004 (PubMed 14744536)).(supplied by OMIM, Nov 2009)

GeneCards Summary for ITIH2 Gene:
ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) is a protein-coding gene. Diseases associated with ITIH2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH5.

UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
hyaluronan which are essential to cells undergoing biological processes

Gene Wiki entry for ITIH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITIH2 gene promoter:
         HFH-3   Olf-1   MyoD   STAT5A   MZF-1   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITIH2 promoter sequence
   Search Chromatin IP Primers for ITIH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p14

ITIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P007785:  view genomic region     (about GC identifiers)

Start:
7,745,232 bp from pter      End:
7,791,483 bp from pter
Size:
46,252 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H2 precursor  
Size: 946 amino acids; 106463 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one
light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like
inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Mass spectrometry: Mass=76508; Method=MALDI; Range=55-702; Source=PubMed:9677337;
Sequence caution: Sequence=CAA30160.1; Type=Frameshift; Positions=363, 373;
Secondary accessions: Q14659 Q15484 Q5T986

Explore the universe of human proteins at neXtProt for ITIH2: NX_P19823

Explore proteomics data for ITIH2 at MOPED

Post-translational modifications: 

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal
    aspartate after propeptide cleavage (By similarity)1
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Phosphorylation sites are present in the extracellular medium1
  • Glycosylation2 at Asn118, Asn445, Thr601, Thr666, Ser673, Thr675, Thr691
  • Modification sites at PhosphoSitePlus

  • See ITIH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002207.2  
    ENSEMBL proteins: 
     ENSP00000351190   ENSP00000388826   ENSP00000368906  

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    Cloud-Clone Corp. CLIAs for ITIH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013694 VIT
     IPR010600 ITI_HC_C
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P19823

    ProtoNet protein and cluster: P19823

    3 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB006587 Vault protein inter-alpha-trypsin
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    ITIH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITIH2_HUMAN, P19823
    Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
    hyaluronan which are essential to cells undergoing biological processes

         Genatlas biochemistry entry for ITIH2:
    trypsin inhibitor,inter-alpha- (protein HC),heavy chain 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS2476436
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    ITIH2 for ontologies           About GeneDecksing


    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITIH2_HUMAN, P19823: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0070062extracellular vesicular exosome IDA--
    GO:0072562blood microparticle IDA--

    ITIH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITIH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ITIH2
        Cell adhesion Cell-matrix glycoconjugates



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITIH2
    Interactions:

        Search GeneGlobe Interaction Network for ITIH2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ITIH2 (P198232, 3 ENSP000003511904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5C1P365422, 3, ENSP000003491424MINT-63706 I2D: score=5 STRING: ENSP00000349142
    FCER1AP123193I2D: score=1 
    SPINT2O432913I2D: score=1 
    --ENSP000003969204STRING: ENSP00000396920
    --ENSP000003157194STRING: ENSP00000315719
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity TAS2476436
    GO:0030212hyaluronan metabolic process IEA--

    ITIH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITIH2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITIH2 gene: 
    NM_002216.2  

    Unigene Cluster for ITIH2:

    Inter-alpha-trypsin inhibitor heavy chain 2
    Hs.75285  [show with all ESTs]
    Unigene Representative Sequence: NM_002216
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358415(uc001ijs.3) ENST00000473227 ENST00000480387 ENST00000429820
    ENST00000379587 ENST00000477751

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ITIH2

    Additional mRNA sequence: 

    AK225277.1 AK225329.1 AK291379.1 AK297334.1 BC132685.1 M18193.1 M33033.1 X07173.1 

    12 DOTS entries:

    DT.91773739  DT.91773742  DT.91773717  DT.121283125  DT.91773741  DT.92052622  DT.95196601  DT.95262128 
    DT.95262129  DT.95262130  DT.95262134  DT.75193146 

    Selected AceView cDNA sequences (see all 133):

    F12378 AA705166 CB163313 CR624216 CB162003 T61669 R95707 AV660445 
    AA974767 CB162091 F05319 AV660400 BX112392 T17086 CB154176 CB154197 
    AV658595 AA406494 AI114825 CB154170 T28559 AL557835 AI052079 BX444213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITIH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTGAAGG
    ITIH2 Expression
    About this image


    ITIH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
     
     Spleen (Hematopoietic System)
    ITIH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITIH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75285

    UniProtKB/Swiss-Prot: ITIH2_HUMAN, P19823
    Tissue specificity: Plasma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itih21 , 5 inter-alpha trypsin inhibitor, heavy chain 21, 5 82.52(n)1
    83.93(a)1
      2 (6.89 cM)5
    164251  NM_010582.31  NP_034712.21 
     100945935 
    chicken
    (Gallus gallus)
    Aves ITIH21 inter-alpha-trypsin inhibitor heavy chain 2 68.97(n)
    66.67(a)
      419110  NM_001130741.1  NP_001124213.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITIH26
    inter-alpha-trypsin inhibitor heavy chain 2
    61(a)
    1 ↔ 1
    5(204250-231288)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50992 Xenopus laevis transcribed sequence with weak similarity more 80.11(n)    48038751 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.8522 Danio rerio mRNA similar to inter-alpha trypsin inhibitor, more 71.98(n)    BC045924.1 


    ENSEMBL Gene Tree for ITIH2 (if available)
    TreeFam Gene Tree for ITIH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITIH2 gene
    ITIH52  ITIH12  ITIH32  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH2 using alignment to 5 protein entries:     ITIH2_HUMAN (see all proteins):
    ITIH1    DKFZp686G21125    ITIH5    ITIH3    ITIH4

    ITIH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITIH2 (see all 1404)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131045631,2
    C,F--7743347(+) CGCCCG/ATAATT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs736212351,2
    C,F--7743352(+) GTAATT/CCCAGC 1 -- us2k12Minor allele frequency- C:0.08CSA NA 122
    rs1147033221,2
    F--7743377(+) AGGCAG/AGGGAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs23883211,2
    C,A--7743387(+) atcgcG/Ttgaac 1 -- us2k14Minor allele frequency- T:0.09NA CSA 124
    rs23883221,2
    C,F--7743408(+) GAGGTG/TGCAGT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs112552951,2
    C--7743409(+) aggttA/Gcagta 1 -- us2k10--------
    rs1408012691,2
    --7743459(+) AGTGAC/TGCTCC 1 -- us2k10--------
    rs357867901,2
    C--7743470(+) AAAAA-/AGGACT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1848490551,2
    --7743657(+) ACATGC/TCATTG 1 -- us2k10--------
    rs19808601,2
    C,F,A,H--7743666(-) taaaaA/GaCCCA 1 -- us2k1 tfbs312Minor allele frequency- G:0.31NS EA WA NA CSA 628

    HapMap Linkage Disequilibrium report for ITIH2 (7745232 - 7791483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ITIH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732384CNV Deletion23290073
    esv2732373CNV Deletion23290073
    esv1652715CNV Deletion17803354
    esv2606150CNV Deletion19546169
    esv2670009CNV Deletion23128226
    esv1496692CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITIH2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146640    OMIM disorders: --

    7 diseases for ITIH2:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    cervicitis    ovarian cancer
    arthritis    alzheimer's disease    breast cancer


    ITIH2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ITIH2
    Human Genome Epidemiology (HuGE) Navigator: ITIH2 (1 document)

    Export disorders for ITIH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITIH2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with ITIH2)
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    1. A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. (PubMed id 7504674)1, 2, 9 Huang L.... Kimata K. (J. Biol. Chem. 1993)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    5. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha- inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.-P. (FEBS Lett. 1999)
    6. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. (PubMed id 9425062)1, 2 Olsen E.H.N....Enghild J.J. (Biochemistry 1998)
    7. Glycosylation pattern of human inter-alpha-inhibitor heavy chains. (PubMed id 9677337)1, 2 Flahaut C.... Mizon J. (Biochem. J. 1998)
    8. Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. (PubMed id 7513643)1, 2 Morelle W.... Mizon J. (Eur. J. Biochem. 1994)
    9. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. (PubMed id 7516184)1, 2 Wisniewski H.-G.... Vilcek J. (Biochemistry 1994)
    10. Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. (PubMed id 7682553)1, 2 Enghild J.J....Hefta S.A. (J. Biol. Chem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3698 HGNC: 6167 AceView: ITIH2 Ensembl:ENSG00000151655 euGenes: HUgn3698
    ECgene: ITIH2 H-InvDB: ITIH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITIH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITIH2 gene:
    Search GeneIP for patents involving ITIH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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