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Aliases for ITIH2 Gene

Aliases for ITIH2 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain 2 2 3 5
  • Inter-Alpha-Trypsin Inhibitor Complex Component II 3 4
  • Inter-Alpha (Globulin) Inhibitor, H2 Polypeptide 2 3
  • Serum-Derived Hyaluronan-Associated Protein 3 4
  • Inter-Alpha-Inhibitor Heavy Chain 2 3 4
  • ITI Heavy Chain H2 3 4
  • ITI-HC2 3 4
  • SHAP 3 4
  • Inter-Alpha (Globulin) Inhibitor H2 3
  • IGHEP2 4
  • H2P 3

External Ids for ITIH2 Gene

Previous GeneCards Identifiers for ITIH2 Gene

  • GC10P007689
  • GC10P007895
  • GC10P007749
  • GC10P007785

Summaries for ITIH2 Gene

Entrez Gene Summary for ITIH2 Gene

  • The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

GeneCards Summary for ITIH2 Gene

ITIH2 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 2) is a Protein Coding gene. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

UniProtKB/Swiss-Prot for ITIH2 Gene

  • May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Gene Wiki entry for ITIH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH2 Gene

Genomics for ITIH2 Gene

Regulatory Elements for ITIH2 Gene

Enhancers for ITIH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITIH2 on UCSC Golden Path with GeneCards custom track

Promoters for ITIH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITIH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITIH2 Gene

7,703,269 bp from pter
7,749,520 bp from pter
46,252 bases
Plus strand

Genomic View for ITIH2 Gene

Genes around ITIH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITIH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITIH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH2 Gene

Proteins for ITIH2 Gene

  • Protein details for ITIH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H2
    Protein Accession:
    Secondary Accessions:
    • Q14659
    • Q15484
    • Q5T986

    Protein attributes for ITIH2 Gene

    946 amino acids
    Molecular mass:
    106463 Da
    Quaternary structure:
    • I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.
    • Sequence=CAA30160.1; Type=Frameshift; Positions=363, 373; Evidence={ECO:0000305};

neXtProt entry for ITIH2 Gene

Proteomics data for ITIH2 Gene at MOPED

Post-translational modifications for ITIH2 Gene

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Asn 96, Asn 118, Asn 445, Thr 601, Thr 666, Ser 673, Thr 675, and Thr 691
  • Modification sites at PhosphoSitePlus

Other Protein References for ITIH2 Gene

Antibody Products

  • Abcam antibodies for ITIH2

No data available for DME Specific Peptides for ITIH2 Gene

Domains & Families for ITIH2 Gene

Gene Families for ITIH2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VIT domain.
  • Belongs to the ITIH family.
  • Contains 1 VIT domain.
  • Contains 1 VWFA domain.
  • Belongs to the ITIH family.
genes like me logo Genes that share domains with ITIH2: view

Function for ITIH2 Gene

Molecular function for ITIH2 Gene

GENATLAS Biochemistry:
trypsin inhibitor,inter-alpha- (protein HC),heavy chain 2
UniProtKB/Swiss-Prot Function:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
genes like me logo Genes that share phenotypes with ITIH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITIH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ITIH2 Gene

Localization for ITIH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH2 Gene


Subcellular locations from

Jensen Localization Image for ITIH2 Gene COMPARTMENTS Subcellular localization image for ITIH2 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ITIH2: view

Pathways & Interactions for ITIH2 Gene

genes like me logo Genes that share pathways with ITIH2: view

Pathways by source for ITIH2 Gene

1 GeneGo (Thomson Reuters) pathway for ITIH2 Gene

Gene Ontology (GO) - Biological Process for ITIH2 Gene


No data available for SIGNOR curated interactions for ITIH2 Gene

Drugs & Compounds for ITIH2 Gene

No Compound Related Data Available

Transcripts for ITIH2 Gene

Unigene Clusters for ITIH2 Gene

Inter-alpha-trypsin inhibitor heavy chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH2 Gene

No ASD Table

Relevant External Links for ITIH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITIH2 Gene

mRNA expression in normal human tissues for ITIH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITIH2 Gene

This gene is overexpressed in Liver (x50.2).

Protein differential expression in normal tissues from HIPED for ITIH2 Gene

This gene is overexpressed in Serum (27.4), Plasma (13.2), and Synovial fluid (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITIH2 Gene

SOURCE GeneReport for Unigene cluster for ITIH2 Gene Hs.75285

mRNA Expression by UniProt/SwissProt for ITIH2 Gene

Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with ITIH2: view

Protein tissue co-expression partners for ITIH2 Gene

- Elite partner

Primer Products

Orthologs for ITIH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITIH2 35
  • 85.13 (n)
  • 86.47 (a)
ITIH2 36
  • 86 (a)
(Canis familiaris)
Mammalia ITIH2 35
  • 85.2 (n)
  • 86.79 (a)
ITIH2 36
  • 87 (a)
(Mus musculus)
Mammalia Itih2 35
  • 82.52 (n)
  • 83.93 (a)
Itih2 16
Itih2 36
  • 84 (a)
(Monodelphis domestica)
Mammalia ITIH2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 78 (a)
-- 36
  • 82 (a)
(Pan troglodytes)
Mammalia ITIH2 36
  • 96 (a)
(Gallus gallus)
Aves ITIH2 35
  • 68.97 (n)
  • 66.67 (a)
ITIH2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia ITIH2 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itih2 35
  • 63.13 (n)
  • 59.33 (a)
Str.15358 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5099 35
(Danio rerio)
Actinopterygii Dr.852 35
itih2 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2708 35
Species with no ortholog for ITIH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH2 Gene

Gene Tree for ITIH2 (if available)
Gene Tree for ITIH2 (if available)

Paralogs for ITIH2 Gene

Paralogs for ITIH2 Gene

(5) SIMAP similar genes for ITIH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ITIH2: view

Variants for ITIH2 Gene

Sequence variations from dbSNP and Humsavar for ITIH2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7075296 - 7,721,698(+) CCCTA(A/G)CTGCC reference, missense
rs7084817 - 7,732,395(+) ATTTT(C/G)TATCG reference, missense
rs3740217 - 7,738,683(-) CGTTG(C/G)TGAAG reference, missense
rs1887332 -- 7,718,404(-) agatg(C/T)gccca intron-variant
rs1892518 -- 7,749,729(+) CAAGC(C/T)GGGCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ITIH2 Gene

Variant ID Type Subtype PubMed ID
esv2670009 CNV Deletion 23128226
esv1496692 CNV Insertion 17803354
esv2732373 CNV Deletion 23290073
esv2606150 CNV Deletion 19546169
esv1652715 CNV Deletion 17803354
esv2732384 CNV Deletion 23290073

Variation tolerance for ITIH2 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ITIH2 Gene

Disorders for ITIH2 Gene

Relevant External Links for ITIH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITIH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITIH2 Gene

Publications for ITIH2 Gene

  1. A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. (PMID: 7504674) Huang L. … Kimata K. (J. Biol. Chem. 1993) 3 4 23 67
  2. SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. (PMID: 16702221) Zhuo L. … Kimata K. (J. Biol. Chem. 2006) 3 23
  3. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha- inhibitor family and a novel actor of DNA repair? (PMID: 10100603) Jean L. … Salier J.-P. (FEBS Lett. 1999) 2 3
  4. Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. (PMID: 1385302) Salier J.P. … Mattei M.G. (Genomics 1992) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ITIH2 Gene

Sources for ITIH2 Gene