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Aliases for ITIH2 Gene

Aliases for ITIH2 Gene

  • Inter-Alpha-Trypsin Inhibitor Heavy Chain 2 2 3
  • Inter-Alpha-Trypsin Inhibitor Complex Component II 3 4
  • Inter-Alpha (Globulin) Inhibitor, H2 Polypeptide 2 3
  • Serum-Derived Hyaluronan-Associated Protein 3 4
  • Inter-Alpha-Inhibitor Heavy Chain 2 3 4
  • ITI Heavy Chain H2 3 4
  • ITI-HC2 3 4
  • SHAP 3 4
  • Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 3
  • Inter-Alpha (Globulin) Inhibitor H2 3
  • IGHEP2 4
  • H2P 3

External Ids for ITIH2 Gene

Summaries for ITIH2 Gene

Entrez Gene Summary for ITIH2 Gene

  • The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

GeneCards Summary for ITIH2 Gene

ITIH2 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.

UniProtKB/Swiss-Prot for ITIH2 Gene

  • May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Gene Wiki entry for ITIH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITIH2 Gene

Genomics for ITIH2 Gene

Genomic Location for ITIH2 Gene

Start:
7,703,269 bp from pter
End:
7,749,520 bp from pter
Size:
46,252 bases
Orientation:
Plus strand

Genomic View for ITIH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITIH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITIH2 Gene

Regulatory Elements for ITIH2 Gene

Proteins for ITIH2 Gene

  • Protein details for ITIH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19823-ITIH2_HUMAN
    Recommended name:
    Inter-alpha-trypsin inhibitor heavy chain H2
    Protein Accession:
    P19823
    Secondary Accessions:
    • Q14659
    • Q15484
    • Q5T986

    Protein attributes for ITIH2 Gene

    Size:
    946 amino acids
    Molecular mass:
    106463 Da
    Quaternary structure:
    • I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
    SequenceCaution:
    • Sequence=CAA30160.1; Type=Frameshift; Positions=363, 373; Evidence={ECO:0000305};

neXtProt entry for ITIH2 Gene

Proteomics data for ITIH2 Gene at MOPED

Post-translational modifications for ITIH2 Gene

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn118, Asn445, Thr601, Thr666, Ser673, Thr675, and Thr691

Other Protein References for ITIH2 Gene

No data available for DME Specific Peptides for ITIH2 Gene

Domains for ITIH2 Gene

UniProtKB/Swiss-Prot:

ITIH2_HUMAN
Domain:
  • Contains 1 VIT domain.:
    • P19823
  • Contains 1 VWFA domain.:
    • P19823
Family:
  • Belongs to the ITIH family.:
    • P19823
genes like me logo Genes that share domains with ITIH2: view

No data available for Gene Families for ITIH2 Gene

Function for ITIH2 Gene

Molecular function for ITIH2 Gene

GENATLAS Biochemistry: trypsin inhibitor,inter-alpha- (protein HC),heavy chain 2
UniProtKB/Swiss-Prot Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Gene Ontology (GO) - Molecular Function for ITIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 2476436
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with ITIH2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITIH2 Gene

Localization for ITIH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITIH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITIH2 Gene COMPARTMENTS Subcellular localization image for ITIH2 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0070062 extracellular exosome IDA 20458337
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ITIH2: view

Pathways for ITIH2 Gene

genes like me logo Genes that share pathways with ITIH2: view

Gene Ontology (GO) - Biological Process for ITIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 2476436
GO:0030212 hyaluronan metabolic process IEA --
genes like me logo Genes that share ontologies with ITIH2: view

Transcripts for ITIH2 Gene

mRNA/cDNA for ITIH2 Gene

Unigene Clusters for ITIH2 Gene

Inter-alpha-trypsin inhibitor heavy chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITIH2 Gene

No ASD Table

Relevant External Links for ITIH2 Gene

GeneLoc Exon Structure for
ITIH2
ECgene alternative splicing isoforms for
ITIH2

Expression for ITIH2 Gene

mRNA expression in normal human tissues for ITIH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITIH2 Gene

This gene is overexpressed in Liver (50.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITIH2 Gene

SOURCE GeneReport for Unigene cluster for ITIH2 Gene Hs.75285

mRNA Expression by UniProt/SwissProt for ITIH2 Gene

P19823-ITIH2_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with ITIH2: view

Orthologs for ITIH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITIH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITIH2 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITIH2 36
  • 85.13 (n)
  • 86.47 (a)
ITIH2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITIH2 36
  • 85.2 (n)
  • 86.79 (a)
ITIH2 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itih2 36
  • 82.52 (n)
  • 83.93 (a)
Itih2 16
Itih2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITIH2 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves ITIH2 36
  • 68.97 (n)
  • 66.67 (a)
ITIH2 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITIH2 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5099 36
tropical clawed frog
(Silurana tropicalis)
Amphibia itih2 36
  • 63.13 (n)
  • 59.33 (a)
Str.15358 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2708 36
zebrafish
(Danio rerio)
Actinopterygii Dr.852 36
itih2 37
  • 52 (a)
OneToOne
Species with no ortholog for ITIH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITIH2 Gene

ENSEMBL:
Gene Tree for ITIH2 (if available)
TreeFam:
Gene Tree for ITIH2 (if available)

Paralogs for ITIH2 Gene

Paralogs for ITIH2 Gene

Selected SIMAP similar genes for ITIH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ITIH2: view

Variants for ITIH2 Gene

Sequence variations from dbSNP and Humsavar for ITIH2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs733600 -- 7,715,769(-) ATAGA(A/G)TGAAA intron-variant
rs927913 -- 7,718,439(+) cccaa(G/T)acaCT intron-variant
rs927916 -- 7,722,027(+) AACAA(A/T)GGAAT intron-variant
rs927917 -- 7,722,375(+) CAGAG(A/G)AAAGA intron-variant
rs1130634 -- 7,749,351(+) TTGGG(A/G)AATTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ITIH2 Gene

Variant ID Type Subtype PubMed ID
esv2670009 CNV Deletion 23128226
esv1496692 CNV Insertion 17803354
esv2732373 CNV Deletion 23290073
esv2606150 CNV Deletion 19546169
esv1652715 CNV Deletion 17803354
esv2732384 CNV Deletion 23290073

Relevant External Links for ITIH2 Gene

HapMap Linkage Disequilibrium report
ITIH2

Disorders for ITIH2 Gene

Relevant External Links for ITIH2

Genetic Association Database (GAD)
ITIH2
Human Genome Epidemiology (HuGE) Navigator
ITIH2
genes like me logo Genes that share disorders with ITIH2: view

No data available for UniProtKB/Swiss-Prot for ITIH2 Gene

Publications for ITIH2 Gene

  1. A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. (PMID: 7504674) Huang L. … Kimata K. (J. Biol. Chem. 1993) 3 4 23
  2. SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. (PMID: 16702221) Zhuo L. … Kimata K. (J. Biol. Chem. 2006) 3 23
  3. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. (PMID: 9425062) Olsen E.H.N. … Enghild J.J. (Biochemistry 1998) 3 4
  4. Glycosylation pattern of human inter-alpha-inhibitor heavy chains. (PMID: 9677337) Flahaut C. … Mizon J. (Biochem. J. 1998) 3 4
  5. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha- inhibitor family and a novel actor of DNA repair? (PMID: 10100603) Jean L. … Salier J.-P. (FEBS Lett. 1999) 2 3

Products for ITIH2 Gene

Sources for ITIH2 Gene

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