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ITIH1 Gene

protein-coding   GIFtS: 61
GCID: GC03P052811

Inter-Alpha-Trypsin Inhibitor Heavy Chain 1

(Previous names: inter-alpha (globulin) inhibitor, H1 polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain 11 2     SHAP2 3
Inter-Alpha (Globulin) Inhibitor, H1 Polypeptide1 2     ITI Heavy Chain H12 3
Inter-Alpha-Inhibitor Heavy Chain 12 3     H1P2
Inter-Alpha-Trypsin Inhibitor Complex Component III2 3     IATIH2
Serum-Derived Hyaluronan-Associated Protein2 3     ITIH2
IGHEP12 3     Inter-Alpha (Globulin) Inhibitor H12
ITI-HC12 3     Inter-Alpha-Trypsin Inhibitor Heavy Chain H12

External Ids:    HGNC: 61661   Entrez Gene: 36972   Ensembl: ENSG000000559577   OMIM: 1472705   UniProtKB: P198273   

Export aliases for ITIH1 gene to outside databases

Previous GC identifers: GC03P051903 GC03P052063 GC03P052666 GC03P052768 GC03P052787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITIH1 Gene:
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry
hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for ITIH1 Gene:
ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and calcium ion binding. An important paralog of this gene is ITIH5.

UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
hyaluronan which are essential to cells undergoing biological processes
Function: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells

Gene Wiki entry for ITIH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITIH1 gene promoter:
         Pax-5   MIF-1   Evi-1   MEF-2A   CREB   POU2F1   POU2F1a   deltaCREB   aMEF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITIH1 promoter sequence
   Search Chromatin IP Primers for ITIH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITIH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

ITIH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052811:  view genomic region     (about GC identifiers)

Start:
52,811,603 bp from pter      End:
52,826,078 bp from pter
Size:
14,476 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H1 precursor  
Size: 911 amino acids; 101389 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one
light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like
inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Mass spectrometry: Mass=76258; Method=MALDI; Range=28-672; Source=PubMed:9677337;
Secondary accessions: A8K9N5 B2RAH9 B7Z558 B7Z8C0 F5H165 F5H7Y8 P78455 Q01746 Q562G1
Alternative splicing: 3 isoforms:  P19827-1   P19827-2   P19827-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITIH1: NX_P19827

Explore proteomics data for ITIH1 at MOPED

Post-translational modifications: 

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal
    aspartate after propeptide cleavage1
  • The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal1
  • Glycosylation2 at Cys60, Asn285, Asn588, Thr653, Asn750
  • Modification sites at PhosphoSitePlus

  • See ITIH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001159906.1  NP_001159907.1  NP_001159908.1  NP_002206.2  

    ENSEMBL proteins: 
     ENSP00000273283   ENSP00000417340   ENSP00000395836   ENSP00000419957   ENSP00000384589  
     ENSP00000442584   ENSP00000443973   ENSP00000443847  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013694 VIT
     IPR010600 ITI_HC_C
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P19827

    ProtoNet protein and cluster: P19827

    3 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB006587 Vault protein inter-alpha-trypsin
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITIH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITIH1_HUMAN, P19827
    Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
    hyaluronan which are essential to cells undergoing biological processes
    Function: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells

         Genatlas biochemistry entry for ITIH1:
    trypsin inhibitor,inter-alpha- (protein HC),heavy chain 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005509calcium ion binding TAS2446322
    GO:0009982pseudouridine synthase activity ----
         
    Find genes that share ontologies with ITIH1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ITIH1:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITIH1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITIH1
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    miRTarBase miRNAs that target ITIH1:
    hsa-mir-335-5p (MIRT018625)

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    2 qRT-PCR Assays for microRNAs that regulate ITIH1:
    hsa-miR-514 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidITIH1 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITIH1_HUMAN, P19827: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with ITIH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITIH1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ITIH1
        Cell adhesion Cell-matrix glycoconjugates


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITIH1
    Interactions:

        Search GeneGlobe Interaction Network for ITIH1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ITIH1 (P198273 ENSP000002732834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    PIK3CAP423363, ENSP000002639674I2D: score=2 STRING: ENSP00000263967
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis ----
    GO:0009451RNA modification ----
    GO:0030212hyaluronan metabolic process IEA--
    GO:0045321leukocyte activation ----

    Find genes that share ontologies with ITIH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITIH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITIH1 gene (4 alternative transcripts): 
    NM_001166434.2  NM_001166435.2  NM_001166436.2  NM_002215.3  

    Unigene Cluster for ITIH1:

    Inter-alpha-trypsin inhibitor heavy chain 1
    Hs.420257  [show with all ESTs]
    Unigene Representative Sequence: NM_002215
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273283(uc003dfs.3 uc010hmn.2 uc003dft.3) ENST00000480409
    ENST00000487686 ENST00000478667 ENST00000494603 ENST00000428133 ENST00000484844
    ENST00000405128 ENST00000482836 ENST00000494705 ENST00000542827 ENST00000540715(uc021wzf.1)
    ENST00000537050(uc021wzg.1 uc021wzh.1)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ITIH1:
    hsa-miR-514 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidITIH1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): ITIH1 (NM_002215)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITIH1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITIH1
      QuantiTect SYBR Green Assays in human, mouse, rat ITIH1
      QuantiFast Probe-based Assays in human, mouse, rat ITIH1

    Additional mRNA sequence: 

    AK292750.1 AK298423.1 AK298455.1 AK303110.1 AK303156.1 AK314198.1 BC069464.1 BC109115.2 
    M18192.1 X16260.1 X63652.1 

    8 DOTS entries:

    DT.417972  DT.95263611  DT.86846035  DT.417974  DT.91755748  DT.100648229  DT.100767147  DT.120898361 

    Selected AceView cDNA sequences (see all 161):

    BX496430 CB120342 AV654789 CB157497 X16260 AV645946 T28458 AA340415 
    BC069464 AI382871 CR615727 AV656946 CR602479 M18192 BX422527 AV652083 
    AA331350 H53064 BX427467 BX496328 AI207427 BX422526 BV167896 NM_002215 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITIH1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^
    SP1:                                -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ITIH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITIH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTCCATTA
    ITIH1 Expression
    About this image


    ITIH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    ITIH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITIH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420257
        Custom PCR Arrays for ITIH1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITIH1
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    QuantiTect SYBR Green Assays in human, mouse, rat ITIH1
    QuantiFast Probe-based Assays in human, mouse, rat ITIH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itih11 , 5 inter-alpha trypsin inhibitor, heavy chain 11, 5 83.57(n)1
    82.36(a)1
      14 (19.09 cM)5
    164241  NM_008406.31  NP_032432.21 
     309291805 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    49(a)
    1 → many
    12(770513-787917)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    52(a)
    49(a)
    many ↔ many
    many ↔ many
    2(154965390-154997505)
    2(154929165-154963400)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1103776
    CR558302.36
    Uncharacterized protein
    42(a)
    42(a)
    many ↔ many
    many ↔ many
    11(3676435-3691325) ENSDARG00000055036
    11(3692744-3708796) ENSDARG00000055053


    ENSEMBL Gene Tree for ITIH1 (if available)
    TreeFam Gene Tree for ITIH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITIH1 gene
    ITIH52  ITIH32  ITIH22  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH1 using alignment to 6 protein entries:     ITIH1_HUMAN (see all proteins):
    ITIH3    DKFZp686G21125    ITIH2    ITIH4    ITIH5

    Find genes that share paralogs with ITIH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ITIH1_HUMAN, P19827: There are 3 common alleles; ITIH1*1 with Glu-585/Gln-595, ITIH1*2 with Val-585/Arg-595 and ITIH1*3
    with Glu-585/Arg-595


    Selected SNPs for ITIH1 (see all 579)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402858591,2
    --52742067(+) GAACTC/GCTGTC 1 -- us2k10--------
    rs1918663731,2
    --52742110(+) ACATGA/GTGGCC 1 -- us2k10--------
    rs1441592441,2
    --52742141(+) GACCTC/GGTTTG 1 -- us2k10--------
    rs1473530201,2
    --52742159(+) GTTCTC/GTCTCT 1 -- us2k10--------
    rs1842517481,2
    --52742194(+) ACGTTA/GCGAGG 1 -- us2k10--------
    rs170524271,2
    C,F,H--52742249(+) TGAGTC/TCTCGA 1 -- us2k122Minor allele frequency- T:0.12NA NS EA WA CSA 1888
    rs1484211191,2
    --52742330(+) AGGAAC/GCTCAC 1 -- us2k10--------
    rs1889199531,2
    --52742359(+) TGGGTA/CAGAAC 1 -- us2k10--------
    rs1425697251,2
    C--52742395(+) AAAGCA/GCAGAT 1 -- us2k10--------
    rs1931594791,2
    --52742577(+) AAACAC/GTCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITIH1 (52811603 - 52826078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ITIH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725279CNV Deletion23290073
    nsv508928CNV Insertion20534489
    nsv876797CNV Loss21882294
    nsv834698CNV Gain17160897

    Human Gene Mutation Database (HGMD): ITIH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITIH1
    DNA2.0 Custom Variant and Variant Library Synthesis for ITIH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147270    OMIM disorders: --


    Find genes that share disorders with ITIH1           About GenesLikeMe

    Genetic Association Database (GAD): ITIH1
    Human Genome Epidemiology (HuGE) Navigator: ITIH1 (2 documents)

    Export disorders for ITIH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITIH1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with ITIH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. (PubMed id 7522574)1, 2, 9 Diarra-Mehrpour M.... Martin J.-P. (Biochim. Biophys. Acta 1994)
    2. Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene. (PubMed id 7505744)1, 2, 9 Bost F....Diarra-Mehrpour M. (Eur. J. Biochem. 1993)
    3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)1, 4 Scott L.J....Boehnke M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (Proteomics 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha- inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.-P. (FEBS Lett. 1999)
    9. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. (PubMed id 9425062)1, 2 Olsen E.H.N....Enghild J.J. (Biochemistry 1998)
    10. Glycosylation pattern of human inter-alpha-inhibitor heavy chains. (PubMed id 9677337)1, 2 Flahaut C.... Mizon J. (Biochem. J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3697 HGNC: 6166 AceView: ITIH1 Ensembl:ENSG00000055957 euGenes: HUgn3697
    ECgene: ITIH1 H-InvDB: ITIH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITIH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITIH1 gene:
    Search GeneIP for patents involving ITIH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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