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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITIH1 Gene

protein-coding   GIFtS: 59
GCID: GC03P052787

inter-alpha-trypsin inhibitor heavy chain 1

(Previous names: inter-alpha (globulin) inhibitor, H1 polypeptide )
 Explore 2 diseases affiliated with
ITIH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITIH1    

Aliases
for ITIH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inter-Alpha-Trypsin Inhibitor Heavy Chain 11 2     Serum-Derived Hyaluronan-Associated Protein2 3
H1P1 2     IGHEP12 3
IATIH1 2     ITI-HC12 3
ITIH1 2     SHAP2 3
Inter-Alpha (Globulin) Inhibitor, H1 Polypeptide1 2     ITI Heavy Chain H12 3
Inter-Alpha-Inhibitor Heavy Chain 12 3     Inter-Alpha (Globulin) Inhibitor H12
Inter-Alpha-Trypsin Inhibitor Complex Component III2 3     Inter-Alpha-Trypsin Inhibitor Heavy Chain H12

External Ids:    HGNC: 61661   Entrez Gene: 36972   Ensembl: ENSG000000559577   OMIM: 1472705   UniProtKB: P198273   

Export aliases for ITIH1 gene to outside databases

Previous GC identifers: GC03P051903 GC03P052063 GC03P052666 GC03P052768


Summaries
for ITIH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITIH1:
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan
in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
hyaluronan which are essential to cells undergoing biological processes
Function: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells

Gene Wiki entry for ITIH1


Genomic Views
for ITIH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITIH1 gene promoter:
         Pax-5   MIF-1   Evi-1   MEF-2A   CREB   POU2F1   POU2F1a   deltaCREB   aMEF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITIH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITIH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITIH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

ITIH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITIH1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052787:  view genomic region     (about GC identifiers)

Start:
 52,811,603 bp from pter      End:
 52,826,078 bp from pter
Size:
 14,476 bases      Orientation:
 plus strand

Proteins
for ITIH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827 (See protein sequence)
Recommended Name: Inter-alpha-trypsin inhibitor heavy chain H1 precursor  
Size: 911 amino acids; 101389 Da
Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light
chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor
(I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin
Subcellular location: Secreted
Mass spectrometry: Mass=76258; Method=MALDI; Range=28-672; Source=PubMed:9677337;
Secondary accessions: A8K9N5 B2RAH9 B7Z558 B7Z8C0 F5H165 F5H7Y8 P78455 Q01746 Q562G1
Alternative splicing: 3 isoforms:  P19827-1   P19827-2   P19827-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITIH1: NX_P19827

Post-translational modifications:

  • Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal
    • aspartate after propeptide cleavage1
  • The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19827

    • ITIH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001159906.1  NP_001159907.1  NP_001159908.1  NP_002206.2  

    ENSEMBL proteins: 
     ENSP00000273283   ENSP00000417340   ENSP00000395836   ENSP00000419957   ENSP00000384589  
     ENSP00000442584   ENSP00000443973   ENSP00000443847  

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    Uscn Proteins for ITIH1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574


    ITIH1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ITIH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITIH1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR010600 ITI_HC_C
     IPR013694 VIT
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P19827

    ProtoNet protein and cluster: P19827

    3 Blocks protein families:
    IPB002035 Von Willebrand factor type A domain signature
    IPB006587 Vault protein inter-alpha-trypsin
    IPB010600 Inter-alpha-trypsin inhibitor heavy chain


    UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
    Similarity: Belongs to the ITIH family
    Similarity: Contains 1 VIT domain
    Similarity: Contains 1 VWFA domain


    Function
    for ITIH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
    Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of
    hyaluronan which are essential to cells undergoing biological processes
    Function: Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells

         Genatlas biochemistry entry for ITIH1:
    trypsin inhibitor,inter-alpha- (protein HC),heavy chain 1

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ITIH1:
    hsa-miR-514 hsa-miR-514b-3p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005509calcium ion binding TAS2446322


    ITIH1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ITIH1:
     Increased S DNA content 


    Pathways & Interactions
    for ITIH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Cell-matrix glycoconjugates
    		Cell adhesion_Cell-matrix glycoconjugates1.00
    		Cell adhesion Cell-matrix glycoconjugates0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ITIH1
        Cell adhesion Cell-matrix glycoconjugates


    1 GeneGo (Thomson Reuters) Pathway for ITIH1
        Cell adhesion Cell-matrix glycoconjugates



    ITIH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITIH1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ITIH1 (P198273 ENSP000002732834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    PIK3CAP423363, ENSP000002639674I2D: score=2 STRING: ENSP00000263967
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030212hyaluronan metabolic process NAS--
    GO:0045321leukocyte activation NAS--


    ITIH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITIH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITIH1
    Search CenterWatch for drugs/clinical trials and news about ITIH1 

    Transcripts
    for ITIH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITIH1 gene (4 alternative transcripts): 
    NM_001166434.2  NM_001166435.2  NM_001166436.2  NM_002215.3  

    Unigene Cluster for ITIH1:

    Inter-alpha-trypsin inhibitor heavy chain 1
    Hs.420257  [show with all ESTs]
    Unigene Representative Sequence: NM_002215
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273283(uc003dfs.3 uc010hmn.2 uc003dft.3) ENST00000480409
    ENST00000487686 ENST00000478667 ENST00000494603 ENST00000428133 ENST00000484844
    ENST00000405128 ENST00000482836 ENST00000494705 ENST00000542827 ENST00000540715(uc021wzf.1)
    ENST00000537050(uc021wzg.1 uc021wzh.1)

    miRNA
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    hsa-miR-514 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ITIH1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITIH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITIH1

    Additional cDNA sequence: 

    AK292750.1 AK298423.1 AK298455.1 AK303110.1 AK303156.1 AK314198.1 BC069464.1 BC109115.2 
    M18192.1 X16260.1 X63652.1 

    8 DOTS entries:

    DT.417972  DT.95263611  DT.86846035  DT.417974  DT.91755748  DT.100648229  DT.100767147  DT.120898361 

    24/161 AceView cDNA sequences (see all 161):

    AA331350 CR615727 CR602479 M18192 AV645946 AV654789 AV652083 CB120342 
    H53064 BX427467 X16260 BX496430 AV656946 CB157497 AI382871 BC069464 
    T28458 AA340415 BX422527 BX426769 CD614250 AI207427 BU615666 AV692472 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ITIH1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^
    SP1:                                -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ITIH1

    Expression
    for ITIH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITIH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTCCATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITIH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ITIH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITIH1

    SOURCE GeneReport for Unigene cluster: Hs.420257
        SABiosciences Custom PCR Arrays for ITIH1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITIH1

    Orthologs
    for ITIH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ITIH1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ITIH66
    		 --
    		 28(a)
    		 1 ↔ 1
    		 Un(38663582-38664560)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR558302.36
    zgc:1103776
    		 zgc:110377
    		 42(a)
    41(a)
    		 possible ortholog
    possible ortholog
    		 11(3692744-3708796)
    11(3676435-3691325)


    ENSEMBL Gene Tree for ITIH1 (if available)
    TreeFam Gene Tree for ITIH1 (if available) 

    Paralogs
    for ITIH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITIH1 gene
    ITIH52  ITIH32  ITIH22  ITIH42  ITIH62  
    5 SIMAP similar genes for ITIH1 using alignment to 6 protein entries:     ITIH1_HUMAN (see all proteins):
    ITIH3    DKFZp686G21125    ITIH2    ITIH4    ITIH5

    ITIH1 for paralogs           About GeneDecksing



    Genomic Variants
    for ITIH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ITIH1_HUMAN, P19827
    Polymorphism: There are 3 common alleles; ITIH1*1 with Glu-585/Gln-595, ITIH1*2 with Val-585/Arg-595 and ITIH1*3 with
    Glu-585/Arg-595


    10/417 NCBI SNPs in ITIH1 are shown (see all 417)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1402858591,2
    		--52809814(+) GAACTC/GCTGTC 1 -- us2k10--------
    rs1918663731,2
    		--52809857(+) ACATGA/GTGGCC 1 -- us2k10--------
    rs1441592441,2
    		--52809888(+) GACCTC/GGTTTG 1 -- us2k10--------
    rs1473530201,2
    		--52809906(+) GTTCTC/GTCTCT 1 -- us2k10--------
    rs1842517481,2
    		--52809941(+) ACGTTA/GCGAGG 1 -- us2k10--------
    rs1484211191,2
    		--52810077(+) AGGAAC/GCTCAC 1 -- us2k10--------
    rs1889199531,2
    		--52810106(+) TGGGTA/CAGAAC 1 -- us2k10--------
    rs1425697251,2
    		--52810142(+) AAAGCA/GCAGAT 1 -- us2k10--------
    rs1931594791,2
    		--52810324(+) AAACAC/GTCTGG 1 -- us2k10--------
    rs1487545991,2
    		C,--52810370(+) TTCTT-/TTTTC 
                TTTTC     		1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITIH1 (52811603 - 52826078 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ITIH1
         1 CNV: 4339
    Human Gene Mutation Database (HGMD): ITIH1

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    Disorders / Diseases
    for ITIH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITIH1 for disorders           About GeneDecksing

    OMIM gene information: 147270    OMIM disorders: --

    2 diseases for ITIH1:    About MalaCards
    bipolar disorder    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: ITIH1 (2 documents)

    Export disorders for ITIH1 gene to outside databases

    Publications
    for ITIH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITIH1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ITIH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. (PubMed id 7522574)1, 2, 9 Diarra-Mehrpour M.... Martin J.-P. (1994)
    2. Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene. (PubMed id 7505744)1, 2, 9 Bost F....Diarra-Mehrpour M. (1993)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    6. The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? (PubMed id 10100603)1, 3 Jean L....Salier J.P. (1999)
    7. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. (PubMed id 9425062)1, 2 Olsen E.H.N....Enghild J.J. (1998)
    8. Glycosylation pattern of human inter-alpha-inhibitor heavy chains. (PubMed id 9677337)1, 2 Flahaut C.... Mizon J. (1998)
    9. Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism. (PubMed id 7535743)1, 2 Ding M.... Suzuki T. (1995)
    10. Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. (PubMed id 7513643)1, 2 Morelle W.... Mizon J. (1994)

    External Searches for ITIH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITIH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3697 HGNC: 6166 AceView: ITIH1 Ensembl:ENSG00000055957 euGenes: HUgn3697
    ECgene: ITIH1 H-InvDB: ITIH1

    Other Databases showing ITIH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITIH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITIH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ITIH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITIH1 gene:
    Search GeneIP for patents involving ITIH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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