Aliases for ITIH1 Gene
External Ids for ITIH1 Gene
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for ITIH1 Gene
ITIH1 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH6.
UniProtKB/Swiss-Prot for ITIH1 Gene
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes
Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells