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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGBL1 Gene

protein-coding   GIFtS: 51
GCID: GC13P102104

Integrin, Beta-Like 1 (With EGF-Like Repeat Domains)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Beta-Like 1 (With EGF-Like Repeat Domains)1 2     ITGBL11
TIED2 3 5     Integrin Beta-Like 11
Osteoblast-Specific Cysteine-Rich Protein2 3     Ten Integrin EGF-Like Repeat Domains Protein1
Ten Integrin EGF-Like Repeat Domain-Containing Protein2 3     Integrin Beta-Like Protein 12
OSCP2 3     

External Ids:    HGNC: 61641   Entrez Gene: 93582   Ensembl: ENSG000001985427   OMIM: 6042345   UniProtKB: O959653   

Export aliases for ITGBL1 gene to outside databases

Previous GC identifers: GC13P100464 GC13P096492 GC13P100941 GC13P099802 GC13P100902 GC13P082698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGBL1 Gene:
This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded
protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for ITGBL1 Gene: 
ITGBL1 (integrin, beta-like 1 (with EGF-like repeat domains)) is a protein-coding gene. Diseases associated with ITGBL1 include isolated growth hormone deficiency, and growth hormone deficiency. GO annotations related to this gene include receptor activity and receptor binding. An important paralog of this gene is ITGB3.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGBL1 gene promoter:
         Sp1   NF-AT   HEN1   AREB6   N-Myc   NF-AT4   NF-AT2   NF-AT3   ZID   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGBL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGBL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33   Ensembl cytogenetic band:  13q33.1   HGNC cytogenetic band: 13q33

ITGBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGBL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P102104:  view genomic region     (about GC identifiers)

Start:
102,104,966 bp from pter      End:
102,375,456 bp from pter
Size:
270,491 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITGBL_HUMAN, O95965 (See protein sequence)
Recommended Name: Integrin beta-like protein 1 precursor  
Size: 494 amino acids; 53921 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A8K5M5 Q8N172 Q9NPR0

Explore the universe of human proteins at neXtProt for ITGBL1: NX_O95965

Explore proteomics data for ITGBL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95965

  • ITGBL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGBL1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001258683.1  NP_001258684.1  NP_001258685.1  NP_004782.1  

    ENSEMBL proteins: 
     ENSP00000365351   ENSP00000439903   ENSP00000475328   ENSP00000365332  

    Human Recombinant Protein Products for ITGBL1: 
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    Novus Biologicals ITGBL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    ITGBL1 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR027070 Integrin_b-like_p1
     IPR000742 EG-like_dom
     IPR015812 Integrin_bsu
     IPR013111 EGF_extracell

    Graphical View of Domain Structure for InterPro Entry O95965

    ProtoNet protein and cluster: O95965

    UniProtKB/Swiss-Prot: ITGBL_HUMAN, O95965
    Domain: Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like'
    structure of integrin beta-subunits


    ITGBL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for ITGBL1:
    integrin beta-like 1,expressed in aorta,thymus and osteogenic sarcoma

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ITGBL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGBL1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGBL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGBL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGBL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGBL1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGBL1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGBL1:
    hsa-miR-3130-5p hsa-miR-576-5p hsa-miR-493* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidITGBL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGBL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITGBL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for ITGBL1 (ENSP000003653514) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA1ENSP000002825884STRING: ENSP00000282588
    ITGA10ENSP000003583104STRING: ENSP00000358310
    ITGA11ENSP000003272904STRING: ENSP00000327290
    ITGA2ENSP000002965854STRING: ENSP00000296585
    ITGA2BENSP000002624074STRING: ENSP00000262407
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10051402
    GO:0007229integrin-mediated signaling pathway ----

    ITGBL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGBL1 (ITGBL)

    Search CenterWatch for drugs/clinical trials and news about ITGBL1 / ITGBL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGBL1 gene (4 alternative transcripts): 
    NM_001271754.1  NM_001271755.1  NM_001271756.1  NM_004791.2  

    Unigene Cluster for ITGBL1:

    Integrin, beta-like 1 (with EGF-like repeat domains)
    Hs.696554  [show with all ESTs]
    Unigene Representative Sequence: NM_001271754
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376180(uc001vpb.3 uc010agb.3) ENST00000545560(uc001vpc.4)
    ENST00000490242 ENST00000474233 ENST00000415285 ENST00000376162
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGBL1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGBL1:
    hsa-miR-3130-5p hsa-miR-576-5p hsa-miR-493* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidITGBL1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGBL1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGBL1
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    Additional mRNA sequence: 

    AB008375.1 AF072752.1 AF339779.1 AK026784.1 AK075136.1 AK095875.1 AK291340.1 AK297744.1 
    AK298571.1 AK308194.1 AL359052.1 BC036788.1 

    11 DOTS entries:

    DT.75197173  DT.40215907  DT.40282582  DT.120777501  DT.413246  DT.209580  DT.100787544  DT.404361 
    DT.120777625  DT.100787546  DT.120777664 

    24/98 AceView cDNA sequences (see all 98):

    CA449252 CN483891 AA136596 N52533 BQ015050 AW338787 BU069083 BU625700 
    BQ009385 CN482498 AA417383 AI753009 CA422150 CD514972 AU280353 AI679980 
    BQ002422 BX282054 AI753986 AI752854 AL359052 BM556124 AI189000 AW072918 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ITGBL1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                                                            -         
    SP4:                    -     -                                                                           


    ECgene alternative splicing isoforms for ITGBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGBL1 expression in normal human tissues (normalized intensities)      ITGBL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATTCACA
    ITGBL1 Expression
    About this image


    ITGBL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
             TGFbeta3+BMP7-induced chondrocytes
             Knee Normal Human Articular chondrocytes (knNHAC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Epiphyseal End
             Human fetal bone marrow-derived mesenchymal stromal cells
             TGFbeta3+BMP7-induced chondrocytes
             Normal Human osteoblasts (NHOST)   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Mature Cardiac Fibroblasts Myocardium
             Left Ventricle
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
             optic nerve head astrocytes   

    See ITGBL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGBL1

    SOURCE GeneReport for Unigene cluster: Hs.696554

    UniProtKB/Swiss-Prot: ITGBL_HUMAN, O95965
    Tissue specificity: Widely expressed in many tissues, but readily detectable only in aorta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGBL1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgbl11 , 5 integrin, beta-like 11, 5 87.99(n)1
    90.89(a)1
      14 (66.10 cM)5
    2232721  NM_145467.21  NP_663442.21 
     1236599715 
    chicken
    (Gallus gallus)
    Aves ITGBL11 integrin, beta-like 1 (with EGF-like repeat domains) 80.26(n)
    83.95(a)
      418769  XM_416966.2  XP_416966.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITGBL16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    3(100319723-100417964)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046744.12   -- 81.25(n)    BC046744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itgbl11 integrin, beta-like 1 67.5(n)
    69.08(a)
      554050  NM_001024072.1  NP_001019243.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta betaInt-nu6
    beta[nu] integrin
    9(a)
    1 → many
    2L(21053033-21058044)
    worm
    (Caenorhabditis elegans)
    Secernentea C05D9.36
    Uncharacterized integrin beta-like protein C05D9.3...
    15(a)
    possible ortholog
    X(1111903-1116794)


    ENSEMBL Gene Tree for ITGBL1 (if available)
    TreeFam Gene Tree for ITGBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGBL1 gene
    ITGB32  ITGB42  ITGB82  ITGB62  ITGB12  ENSG000002597532  ITGB52  ITGB72  
    ITGB22  

    ITGBL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5725 SNPs in ITGBL1 are shown (see all 5725)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619737461,2
    C--83028872(+) TCACAC/TGTGGG 2 -- us2k12Minor allele frequency- T:0.04NA 122
    rs792897291,2
    C,F--83028903(+) GAATTT/GGTACT 2 -- us2k12Minor allele frequency- G:0.06CSA WA 120
    rs1855046911,2
    --83028950(+) CCCTCA/TGGCGT 2 -- us2k10--------
    rs1169752271,2
    C,F--83029094(+) AGTTCC/TCAAAT 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs754887661,2
    C,F--83029132(+) ACCACG/ACTTTA 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs73198331,2
    C,F--83029178(+) TTTAGA/GCAGGC 2 -- us2k11Minor allele frequency- G:0.08NA 120
    rs1485589611,2
    --83029196(+) CCACAA/GGCTGC 2 -- us2k10--------
    rs1907555251,2
    --83029243(+) CTGTGC/TCCTTT 2 -- us2k10--------
    rs1428983841,2
    C--83029260(+) AAGCCA/GCACTT 2 -- us2k10--------
    rs1808377791,2
    --83029529(+) GATTAC/GAGGAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGBL1 (102104966 - 102354966 bp, first 250kb of ITGBL1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ITGBL1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668867CNV Deletion23128226
    nsv1151CNV Insertion18451855
    nsv832701CNV Loss17160897
    nsv510361CNV Loss20534489
    dgv1789n71CNV Loss21882294
    nsv456097CNV Loss19166990
    nsv900970CNV Loss21882294
    nsv523777CNV Loss19592680
    nsv521536CNV Loss19592680
    dgv1788n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604234    OMIM disorders: --

    4 diseases for ITGBL1:    About MalaCards
    isolated growth hormone deficiency    growth hormone deficiency    sarcoma    schizophrenia


    ITGBL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ITGBL1
    Human Genome Epidemiology (HuGE) Navigator: ITGBL1 (4 documents)

    Export disorders for ITGBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGBL1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ITGBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: A divergent stand-alone integrin stalk structure. (PubMed id 10051402)1, 2, 3, 9 Berg R.W....Krissansen G.W. (1999)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)1, 2 Chumakov I.... Cohen D. (2002)
    6. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initia tive SHARe Study. (PubMed id 23192594)1 Velez Edwards D.R....Edwards T.L. (2013)
    7. Mid-gestational gene expression profile in placenta an d link to pregnancy complications. (PubMed id 23145134)1 Uuskula L....Laan M. (2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. Identification of two novel chromosome regions associa ted with isolated growth hormone deficiency. (PubMed id 21284329)1 Cody J.D....Hale D. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9358 HGNC: 6164 AceView: ITGBL1 Ensembl:ENSG00000198542 euGenes: HUgn9358
    ECgene: ITGBL1 H-InvDB: ITGBL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGBL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGBL1 gene:
    Search GeneIP for patents involving ITGBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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