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ITGB8 Gene

protein-coding   GIFtS: 62
GCID: GC07P020370

Integrin, Beta 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Beta 81 2
Integrin Beta-82

External Ids:    HGNC: 61631   Entrez Gene: 36962   Ensembl: ENSG000001058557   OMIM: 6041605   UniProtKB: P260123   

Export aliases for ITGB8 gene to outside databases

Previous GC identifers: GC07P020015 GC07P020115 GC07P020143 GC07P020337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGB8 Gene:
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a
VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a
heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix
interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced
variants which encode different protein isoforms have been described; however, not all variants have been fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGB8 Gene:
ITGB8 (integrin, beta 8) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
Function: Integrin alpha-V/beta-8 is a receptor for fibronectin

Gene Wiki entry for ITGB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGB8 gene promoter:
         TBP   RelA   POU6F1 (c2)   NF-kappaB   HEN1   PPAR-gamma1   TFIID   FOXO4   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGB8 promoter sequence
   Search Chromatin IP Primers for ITGB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p15.3

ITGB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P020370:  view genomic region     (about GC identifiers)

Start:
20,370,325 bp from pter      End:
20,455,382 bp from pter
Size:
85,058 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 20,422,044-20,506,723     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012 (See protein sequence)
Recommended Name: Integrin beta-8 precursor  
Size: 769 amino acids; 85632 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V
Secondary accessions: A4D133

Explore the universe of human proteins at neXtProt for ITGB8: NX_P26012

Explore proteomics data for ITGB8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn233, Asn402, Asn421, Asn431, Asn456, Asn466, Asn648

  • See ITGB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002205.1  
    ENSEMBL proteins: 
     ENSP00000441561   ENSP00000222573  
    Reactome Protein details: P26012

    ITGB8 Human Recombinant Protein Products:

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    Novus Biologicals ITGB8 Protein
    Novus Biologicals ITGB8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGB8 

    ITGB8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ITGB8 (Integrin beta 8)
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    Novus Biologicals ITGB8 Antibodies
    Abcam antibodies for ITGB8
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for ITGB8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    Selected InterPro protein domains (see all 8):
     IPR002369 Integrin_bsu_N
     IPR000742 EG-like_dom
     IPR015812 Integrin_bsu
     IPR016201 Plexin-like_fold
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P26012

    ProtoNet protein and cluster: P26012

    2 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature


    UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGB8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB8_HUMAN, P26012
    Function: Integrin alpha-V/beta-8 is a receptor for fibronectin

         Genatlas biochemistry entry for ITGB8:
    integrin,beta 8,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005102receptor binding IEA--
         
    Find genes that share ontologies with ITGB8           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb8):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  homeostasis/metabolism  mortality/aging  nervous system  normal 
     other 

    Find genes that share phenotypes with ITGB8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itgb8tm1Lfr for ITGB8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGB8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGB8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGB8

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGB8:
    hsa-mir-93-5p (MIRT004104), hsa-mir-335-5p (MIRT019022), hsa-mir-19b-1-5p (MIRT006279), hsa-mir-145-5p (MIRT006494)

    Block miRNA regulation of human, mouse, rat ITGB8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGB8 (see all 158):
    hsa-miR-376b hsa-miR-106a hsa-miR-199a-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-642b hsa-miR-130b hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITGB8
    Predesigned siRNA for gene silencing in human, mouse, rat ITGB8

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ITGB8 (see all 7)
    OriGene ORF clones in mouse, rat for ITGB8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGB8 (NM_002214)
    Sino Biological Human cDNA Clone for ITGB8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB8

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ITGB8
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGB8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITB8_HUMAN, P26012: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ITGB8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGB8 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with ITGB8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGB8 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGB8
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    2 Reactome Pathways for ITGB8
        Molecules associated with elastic fibres
    Integrin cell surface interactions


    Selected Kegg Pathways  (Kegg details for ITGB8) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including ITGB8: 
              Fibrosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ITGB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGB8 (P260123 ENSP000002225734) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=3 STRING: ENSP00000261023
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    VTNP040043, ENSP000002262184I2D: score=1 STRING: ENSP00000226218
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    ACTBENSP000003499604STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001573ganglioside metabolic process IEA--
    GO:0007155cell adhesion TAS1918072
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with ITGB8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGB8 (ITB8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGB8 gene: 
    NM_002214.2  

    Unigene Cluster for ITGB8:

    Integrin, beta 8
    Hs.592171  [show with all ESTs]
    Unigene Representative Sequence: NM_002214
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537992(uc011jyh.2) ENST00000478974(uc003sut.3) ENST00000222573(uc003suu.3)
    ENST00000460204 ENST00000477859
    miRNA
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    Block miRNA regulation of human, mouse, rat ITGB8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGB8 (see all 158):
    hsa-miR-376b hsa-miR-106a hsa-miR-199a-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-642b hsa-miR-130b hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ITGB8
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGB8 (NM_002214)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGB8
      QuantiTect SYBR Green Assays in human, mouse, rat ITGB8
      QuantiFast Probe-based Assays in human, mouse, rat ITGB8

    Additional mRNA sequence: 

    AK295044.1 BC002630.2 BC042028.1 BT006739.1 M73780.1 

    7 DOTS entries:

    DT.408964  DT.95357132  DT.443137  DT.445435  DT.95367911  DT.97843178  DT.100666033 

    Selected AceView cDNA sequences (see all 76):

    BM760896 BM745694 BM760098 BM759177 BM760952 BM760166 BC002630 AL710619 
    AA290800 W56754 BT006739 AA479726 BE378879 AA419179 BI861225 BX484599 
    CD367781 AU137772 BE002931 BX643310 AU157309 BM744224 BM739870 BX957185 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:              -     -                                                     -                       -                                 
    SP2:              -     -                                                     -                                                         
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ITGB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTGTATCA
    ITGB8 Expression
    About this image


    ITGB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Epithelial Cells
             Podocytes Podocyte Layer
    ITGB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592171

    UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
    Tissue specificity: Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed
    in 293 human embryonic kidney cells

        Pathway & Disease-focused RT2 Profiler PCR Array including ITGB8: 
              Fibrosis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGB8
    QuantiTect SYBR Green Assays in human, mouse, rat ITGB8
    QuantiFast Probe-based Assays in human, mouse, rat ITGB8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGB8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb81 , 5 integrin beta 81, 5 86.44(n)1
    87.48(a)1
      12 (63.48 cM)5
    3209101  NM_177290.31  NP_796264.21 
     1191580225 
    chicken
    (Gallus gallus)
    Aves ITGB81 integrin, beta 8 72.35(n)
    72.7(a)
      395470  XM_003640686.2  XP_003640734.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB86
    integrin, beta 8
    68(a)
    1 ↔ 1
    6(29206369-29260582)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itgb81 integrin, beta 8 65.08(n)
    59.37(a)
      100494899  XM_002933298.2  XP_002933344.2 
    zebrafish
    (Danio rerio)
    Actinopterygii itgb81 integrin, beta 8 54.58(n)
    47.31(a)
      556752  XM_001919591.4  XP_001919626.4 


    ENSEMBL Gene Tree for ITGB8 (if available)
    TreeFam Gene Tree for ITGB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGB8 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB72  ITGB22  ITGBL12  ITGB32  ITGB62  
    ITGB52  
    7 SIMAP similar genes for ITGB8 using alignment to 3 protein entries:     ITB8_HUMAN (see all proteins):
    ITGB6    ITGB5    ITGB3    ITGB1    ITGB7    ITGB4
    ITGB2

    Find genes that share paralogs with ITGB8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGB8 (see all 1948)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166899661,2
    F--20368754(+) CTGTGA/TCATAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1143911041,2
    F--20368793(+) GGAAGA/CGTCAC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs624560801,2
    C--20368809(+) AGATAT/CTGAAT 1 -- us2k15Minor allele frequency- C:0.07NA WA EA 362
    rs1493378501,2
    --20368951(+) TAAAGC/TGGAGC 1 -- us2k10--------
    rs1448515371,2
    --20369016(+) AAGGTC/TGGGAT 1 -- us2k10--------
    rs1401532621,2
    --20369036(+) GGTCTA/CGCGAA 1 -- us2k10--------
    rs1456414461,2
    --20369046(+) AGGGAA/CCTGCT 1 -- us2k10--------
    rs1827964641,2
    C--20369127(+) TTGTGC/TGGTCC 1 -- us2k10--------
    rs58827381,2
    C--20369230(+) CCTAC-/T/TT  
            
    ttttt
    1 -- us2k10--------
    rs1173731851,2
    C,F--20369299(+) AAACTC/GCCGCA 1 -- us2k11Minor allele frequency- G:0.05EA 120

    HapMap Linkage Disequilibrium report for ITGB8 (20370325 - 20455382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ITGB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv230n6CNV Loss16902084
    dgv231n6CNV Loss16902084
    nsv365438CNV Loss16902084
    nsv523878CNV Loss19592680
    nsv887834CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGB8
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604160    OMIM disorders: --


    Find genes that share disorders with ITGB8           About GenesLikeMe

    1 Novoseek inferred disease relationship for ITGB8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 1 14571772 (1)

    Genetic Association Database (GAD): ITGB8
    Human Genome Epidemiology (HuGE) Navigator: ITGB8 (3 documents)

    Export disorders for ITGB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGB8 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ITGB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (PubMed id 18549475)1, 4 Blons H....Laurent-Puig P. (BMC Med Genomics 2008)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Cloning and expression of a divergent integrin subunit beta 8. (PubMed id 1918072)1, 2 Moyle M.... McLean J.W. (J. Biol. Chem. 1991)
    6. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. (PubMed id 7525578)1, 9 Nishimura S.L....Pytela R. (J. Biol. Chem. 1994)
    7. I+vI^8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. (PubMed id 23283986)1 Reyes S.B....McCarty J.H. (Mol. Biol. Cell 2013)
    8. Alteration in metastasis potential and gene expression in human lung cancer cell lines by ITGB8 silencing. (PubMed id 22753015)1 Xu Z. and Wu R. (Anat Rec (Hoboken) 2012)
    9. Defective retinal vascular endothelial cell development as a consequence of impaired integrin I+VI^8-mediated activation of transforming growth factor-I^. (PubMed id 22279205)1 Arnold T.D....Reichardt L.F. (J. Neurosci. 2012)
    10. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. (PubMed id 21878622)1 Markovics J.A....Nishimura S.L. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3696 HGNC: 6163 AceView: ITGB8 Ensembl:ENSG00000105855 euGenes: HUgn3696
    ECgene: ITGB8 Kegg: 3696 H-InvDB: ITGB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGB8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGB8 gene:
    Search GeneIP for patents involving ITGB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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