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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGB8 Gene

protein-coding   GIFtS: 63
GCID: GC07P020370

Integrin, Beta 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Beta 81 2
Integrin Beta-82

External Ids:    HGNC: 61631   Entrez Gene: 36962   Ensembl: ENSG000001058557   OMIM: 6041605   UniProtKB: P260123   

Export aliases for ITGB8 gene to outside databases

Previous GC identifers: GC07P020015 GC07P020115 GC07P020143 GC07P020337


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGB8 Gene:
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a
VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a
heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix
interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced
variants which encode different protein isoforms have been described; however, not all variants have been fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGB8 Gene: 
ITGB8 (integrin, beta 8) is a protein-coding gene. Diseases associated with ITGB8 include arteriovenous malformation, and laryngeal squamous cell carcinoma, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include receptor activity and receptor binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
Function: Integrin alpha-V/beta-8 is a receptor for fibronectin

Gene Wiki entry for ITGB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGB8 gene promoter:
         TBP   RelA   POU6F1 (c2)   NF-kappaB   HEN1   PPAR-gamma1   TFIID   FOXO4   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p15.3

ITGB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P020370:  view genomic region     (about GC identifiers)

Start:
20,370,325 bp from pter      End:
20,455,382 bp from pter
Size:
85,058 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 20,422,044-20,506,723     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012 (See protein sequence)
Recommended Name: Integrin beta-8 precursor  
Size: 769 amino acids; 85632 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A4D133

Explore the universe of human proteins at neXtProt for ITGB8: NX_P26012

Explore proteomics data for ITGB8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26012

  • ITGB8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGB8 Protein Expression
    REFSEQ proteins: NP_002205.1  
    ENSEMBL proteins: 
     ENSP00000441561   ENSP00000222573  
    Reactome Protein details: P26012
    Human Recombinant Protein Products for ITGB8: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0016020membrane ----

    ITGB8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ITG: Integrins

    5/9 InterPro protein domains (see all 9):
     IPR002369 Integrin_bsu_N
     IPR000742 EG-like_dom
     IPR015812 Integrin_bsu
     IPR003659 Plexin-like
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry P26012

    ProtoNet protein and cluster: P26012

    2 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature


    UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    ITGB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB8_HUMAN, P26012
    Function: Integrin alpha-V/beta-8 is a receptor for fibronectin

         Genatlas biochemistry entry for ITGB8:
    integrin,beta 8,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
         
    ITGB8 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb8):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  homeostasis/metabolism  mortality/aging  nervous system  normal 
     other 

    ITGB8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itgb8tm1Lfr for ITGB8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGB8 
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    miRTarBase miRNAs that target ITGB8:
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    8/158 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGB8 (see all 158):
    hsa-miR-376b hsa-miR-106a hsa-miR-199a-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-642b hsa-miR-130b hsa-miR-761
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGB8 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB8 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGB8
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    5        Reactome Pathways for ITGB8
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Integrin cell surface interactions
    Elastic fibre formation
    Signal Transduction


    5/8         Kegg Pathways  (Kegg details for ITGB8) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton


    ITGB8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITGB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for ITGB8 (P260123 ENSP000002225734) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=3 STRING: ENSP00000261023
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    VTNP040043, ENSP000002262184I2D: score=1 STRING: ENSP00000226218
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    ACTBENSP000003499604STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001573ganglioside metabolic process IEA--
    GO:0007155cell adhesion TAS1918072
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007275multicellular organismal development ----

    ITGB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGB8 (ITB8)

    Search CenterWatch for drugs/clinical trials and news about ITGB8 / ITB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGB8 gene: 
    NM_002214.2  

    Unigene Cluster for ITGB8:

    Integrin, beta 8
    Hs.592171  [show with all ESTs]
    Unigene Representative Sequence: NM_002214
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537992(uc011jyh.2) ENST00000478974(uc003sut.3) ENST00000222573(uc003suu.3)
    ENST00000460204 ENST00000477859
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/158 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGB8 (see all 158):
    hsa-miR-376b hsa-miR-106a hsa-miR-199a-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-642b hsa-miR-130b hsa-miR-761
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    Additional mRNA sequence: 

    AK295044.1 BC002630.2 BC042028.1 BT006739.1 M73780.1 

    7 DOTS entries:

    DT.408964  DT.95357132  DT.443137  DT.445435  DT.95367911  DT.97843178  DT.100666033 

    24/76 AceView cDNA sequences (see all 76):

    AA290800 AL710619 W56754 BM760896 BM760166 BC002630 BM760098 BM760952 
    BT006739 BM745694 BM759177 CD367781 AA419179 BX484599 W56709 AA479726 
    BM744224 BE002931 AA419198 BF931620 AL710320 BM759989 BM739870 BM739223 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:              -     -                                                     -                       -                                 
    SP2:              -     -                                                     -                                                         
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ITGB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGB8 expression in normal human tissues (normalized intensities)      ITGB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTGTATCA
    ITGB8 Expression
    About this image


    ITGB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocytes Podocyte Layer
             visceral organ/mesonephros of male/mesonephric tubule of male   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal/nerve plexus/brachial plexus   
     
     Peripheral Nervous System (Nervous System)
             spinal/nerve plexus/brachial plexus   
     
     Uterus (Reproductive System)
             endometrium   

    See ITGB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGB8

    SOURCE GeneReport for Unigene cluster: Hs.592171

    UniProtKB/Swiss-Prot: ITB8_HUMAN, P26012
    Tissue specificity: Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed
    in 293 human embryonic kidney cells

        SABiosciences Expression via Pathway-Focused PCR Array including ITGB8: 
              Fibrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGB8 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb81 , 5 integrin beta 81, 5 86.44(n)1
    87.48(a)1
      12 (63.48 cM)5
    3209101  NM_177290.31  NP_796264.21 
     1191580225 
    chicken
    (Gallus gallus)
    Aves ITGB81 integrin, beta 8 73.13(n)
    72.59(a)
      395470  XM_003640686.1  XP_003640734.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB86
    integrin, beta 8
    68(a)
    1 ↔ 1
    6(29206369-29260582)
    zebrafish
    (Danio rerio)
    Actinopterygii itgb81 integrin, beta 8 57.01(n)
    51.66(a)
      556752  XM_001919591.3  XP_001919626.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta betaInt-nu6
    beta[nu] integrin
    24(a)
    1 → many
    2L(21053033-21058044)
    worm
    (Caenorhabditis elegans)
    Secernentea C05D9.36
    Uncharacterized integrin beta-like protein C05D9.3...
    19(a)
    possible ortholog
    X(1111903-1116794)


    ENSEMBL Gene Tree for ITGB8 (if available)
    TreeFam Gene Tree for ITGB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGB8 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB72  ITGB22  ITGB32  ITGBL12  ITGB62  
    ITGB52  
    7 SIMAP similar genes for ITGB8 using alignment to 3 protein entries:     ITB8_HUMAN (see all proteins):
    ITGB6    ITGB5    ITGB3    ITGB1    ITGB7    ITGB4
    ITGB2

    ITGB8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1948 SNPs in ITGB8 are shown (see all 1948)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166899661,2
    F--20368754(+) CTGTGA/TCATAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1143911041,2
    F--20368793(+) GGAAGA/CGTCAC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs624560801,2
    C--20368809(+) AGATAT/CTGAAT 1 -- us2k15Minor allele frequency- C:0.07NA WA EA 362
    rs1493378501,2
    --20368951(+) TAAAGC/TGGAGC 1 -- us2k10--------
    rs1448515371,2
    --20369016(+) AAGGTC/TGGGAT 1 -- us2k10--------
    rs1401532621,2
    --20369036(+) GGTCTA/CGCGAA 1 -- us2k10--------
    rs1456414461,2
    --20369046(+) AGGGAA/CCTGCT 1 -- us2k10--------
    rs1827964641,2
    C--20369127(+) TTGTGC/TGGTCC 1 -- us2k10--------
    rs58827381,2
    C--20369230(+) CCTAC-/T/TT  
            
    ttttt
    1 -- us2k10--------
    rs1173731851,2
    C,F--20369299(+) AAACTC/GCCGCA 1 -- us2k11Minor allele frequency- G:0.05EA 120

    HapMap Linkage Disequilibrium report for ITGB8 (20370325 - 20455382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ITGB8:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv230n6CNV Loss16902084
    dgv231n6CNV Loss16902084
    nsv365438CNV Loss16902084
    nsv523878CNV Loss19592680
    nsv887834CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604160    OMIM disorders: --

    15 diseases for ITGB8:    About MalaCards
    arteriovenous malformation    laryngeal squamous cell carcinoma    polyneuropathy    non-small cell lung carcinoma
    hypertrophic cardiomyopathy    laryngitis    dilated cardiomyopathy    cervical cancer
    glioblastoma    squamous cell carcinoma    cervicitis    hepatitis b
    retinitis    hepatitis    endotheliitis


    ITGB8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ITGB8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 1 14571772 (1)

    Genetic Association Database (GAD): ITGB8
    Human Genome Epidemiology (HuGE) Navigator: ITGB8 (3 documents)

    Export disorders for ITGB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGB8 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with ITGB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (PubMed id 18549475)1, 4 Blons H....Laurent-Puig P. (2008)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Cloning and expression of a divergent integrin subunit beta 8. (PubMed id 1918072)1, 2 Moyle M.... McLean J.W. (1991)
    6. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. (PubMed id 7525578)1, 9 Nishimura S.L....Pytela R. (1994)
    7. avb8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. (PubMed id 23283986)1 Reyes S.B....McCarty J.H. (2013)
    8. Alteration in metastasis potential and gene expression in human lung cancer cell lines by ITGB8 silencing. (PubMed id 22753015)1 Xu Z. and Wu R. (2012)
    9. Defective retinal vascular endothelial cell developmen t as a consequence of impaired integrin aVb8-mediated activation of transforming growth factor-b. (PubMed id 22279205)1 Arnold T.D....Reichardt L.F. (2012)
    10. Interleukin-1beta induces increased transcriptional a ctivation of the transforming growth factor-beta-activating integrin subunit be ta8 through altering chromatin architecture. (PubMed id 21878622)1 Markovics J.A....Nishimura S.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3696 HGNC: 6163 AceView: ITGB8 Ensembl:ENSG00000105855 euGenes: HUgn3696
    ECgene: ITGB8 Kegg: 3696 H-InvDB: ITGB8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGB8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGB8 gene:
    Search GeneIP for patents involving ITGB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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