External Ids for ITGB8 Gene
Previous GeneCards Identifiers for ITGB8 Gene
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGB8 Gene
ITGB8 (Integrin Subunit Beta 8) is a Protein Coding gene. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include receptor binding and extracellular matrix protein binding. An important paralog of this gene is ITGB6.
UniProtKB/Swiss-Prot for ITGB8 Gene
Integrin alpha-V/beta-8 is a receptor for fibronectin.