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Aliases for ITGB7 Gene

Aliases for ITGB7 Gene

  • Integrin, Beta 7 2 3
  • Gut Homing Receptor Beta Subunit 4

External Ids for ITGB7 Gene

Previous GeneCards Identifiers for ITGB7 Gene

  • GC12M053680
  • GC12M053498
  • GC12M053301
  • GC12M051871
  • GC12M053585
  • GC12M050628

Summaries for ITGB7 Gene

Entrez Gene Summary for ITGB7 Gene

  • This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for ITGB7 Gene

ITGB7 (Integrin, Beta 7) is a Protein Coding gene. Diseases associated with ITGB7 include spongiotic dermatitis and exfoliative ichthyosis. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include virus receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB7 Gene

  • Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin

Gene Wiki entry for ITGB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB7 Gene

Genomics for ITGB7 Gene

Regulatory Elements for ITGB7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGB7 Gene

Start:
53,191,318 bp from pter
End:
53,207,307 bp from pter
Size:
15,990 bases
Orientation:
Minus strand

Genomic View for ITGB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB7 Gene

Proteins for ITGB7 Gene

  • Protein details for ITGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26010-ITB7_HUMAN
    Recommended name:
    Integrin beta-7
    Protein Accession:
    P26010
    Secondary Accessions:
    • Q9UCP7
    • Q9UCS7

    Protein attributes for ITGB7 Gene

    Size:
    798 amino acids
    Molecular mass:
    86903 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.

    Three dimensional structures from OCA and Proteopedia for ITGB7 Gene

    Alternative splice isoforms for ITGB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB7 Gene

Proteomics data for ITGB7 Gene at MOPED

Post-translational modifications for ITGB7 Gene

  • Glycosylation at Asn68, Asn279, Asn434, Asn477, Asn531, Asn590, Asn665, and Asn674
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGB7 Gene

Antibody Products

  • R&D Systems Antibodies for ITGB7 (Integrin beta 7)

No data available for DME Specific Peptides for ITGB7 Gene

Domains for ITGB7 Gene

Gene Families for ITGB7 Gene

HGNC:
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P26010

UniProtKB/Swiss-Prot:

ITB7_HUMAN :
  • P26010
Domain:
  • Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB7: view

Function for ITGB7 Gene

Molecular function for ITGB7 Gene

GENATLAS Biochemistry:
integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
UniProtKB/Swiss-Prot Function:
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin
UniProtKB/Swiss-Prot Induction:
Integrin alpha-E/beta-7 is induced by TGFB1.

Gene Ontology (GO) - Molecular Function for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity --
GO:0005515 protein binding IPI 17690686
GO:0046872 metal ion binding IEA --
GO:0050839 cell adhesion molecule binding IMP 23986478
genes like me logo Genes that share ontologies with ITGB7: view
genes like me logo Genes that share phenotypes with ITGB7: view

Animal Models for ITGB7 Gene

MGI Knock Outs for ITGB7:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITGB7 Gene

Localization for ITGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB7 Gene COMPARTMENTS Subcellular localization image for ITGB7 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 2040616
GO:0009986 cell surface IDA 18308860
GO:0016020 membrane IDA 19946888
GO:0034669 integrin alpha4-beta7 complex IDA 18308860
genes like me logo Genes that share ontologies with ITGB7: view

Pathways for ITGB7 Gene

genes like me logo Genes that share pathways with ITGB7: view

Gene Ontology (GO) - Biological Process for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration IMP 23986478
GO:0007155 cell adhesion TAS 2040616
GO:0007160 cell-matrix adhesion IMP 18308860
GO:0007229 integrin-mediated signaling pathway IMP 23986478
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ITGB7: view

Compounds for ITGB7 Gene

(2) HMDB Compounds for ITGB7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4

(4) Novoseek inferred chemical compound relationships for ITGB7 Gene

Compound -log(P) Hits PubMed IDs
apicidin 71.2 2
butyrate 38.3 3
paclitaxel 0.628 2
tyrosine 0 2
genes like me logo Genes that share compounds with ITGB7: view

Transcripts for ITGB7 Gene

Unigene Clusters for ITGB7 Gene

Integrin, beta 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7:

ExUns: 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ITGB7 Gene

GeneLoc Exon Structure for
ITGB7
ECgene alternative splicing isoforms for
ITGB7

Expression for ITGB7 Gene

mRNA expression in normal human tissues for ITGB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB7 Gene

This gene is overexpressed in Whole Blood (12.6) and Spleen (4.9).

Protein differential expression in normal tissues for ITGB7 Gene

This gene is overexpressed in Pancreas (23.1), Peripheral blood mononuclear cells (14.9), and CD8 Tcells (14.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGB7 Gene

SOURCE GeneReport for Unigene cluster for ITGB7 Gene Hs.654470

mRNA Expression by UniProt/SwissProt for ITGB7 Gene

P26010-ITB7_HUMAN
Tissue specificity: Expressed in a variety of leukocyte lines
genes like me logo Genes that share expressions with ITGB7: view

Expression partners for ITGB7 Gene

In Situ Assay Products

Orthologs for ITGB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGB7 35
  • 87.68 (n)
  • 87.59 (a)
ITGB7 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB7 35
  • 86.93 (n)
  • 88.6 (a)
ITGB7 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb7 35
  • 84.46 (n)
  • 87.2 (a)
Itgb7 16
Itgb7 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGB7 35
  • 99.54 (n)
  • 99.75 (a)
ITGB7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb7 35
  • 84.64 (n)
  • 87.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB7 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB7 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itgb7 35
  • 57.79 (n)
  • 55.3 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC797491 35
  • 53.18 (n)
  • 46.31 (a)
itgb7 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bgrInt-ngr 37
  • 30 (a)
mys 37
  • 35 (a)
mys 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pat-3 37
  • 37 (a)
pat-3 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.871 36
  • 34 (a)
OneToMany
Species with no ortholog for ITGB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB7 Gene

ENSEMBL:
Gene Tree for ITGB7 (if available)
TreeFam:
Gene Tree for ITGB7 (if available)

Paralogs for ITGB7 Gene

Selected SIMAP similar genes for ITGB7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ITGB7: view

Variants for ITGB7 Gene

Sequence variations from dbSNP and Humsavar for ITGB7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs867594 -- 53,197,009(-) TAATG(C/T)CTTCT intron-variant
rs869445 -- 53,194,860(+) TCTTG(A/T)GAAGA intron-variant
rs884374 -- 53,194,396(-) TGGGG(C/G/T)TGGAG intron-variant
rs2230397 -- 53,192,414(-) AAGAG(A/C)GGACC synonymous-codon, reference, nc-transcript-variant
rs2272299 -- 53,193,038(+) ACACC(A/G)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB7 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv469404 CNV Loss 19166990
nsv52510 CNV Loss 16902084
dgv27n6 CNV Loss 16902084
nsv52860 CNV Loss 16902084
nsv52501 CNV Loss 16902084

Relevant External Links for ITGB7 Gene

HapMap Linkage Disequilibrium report
ITGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB7 Gene

Disorders for ITGB7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ITGB7 Gene in MalaCards »

(2) Diseases for ITGB7 Gene including...

(7) Novoseek inferred disease relationships for ITGB7 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 29.3 1
encephalomyelitis 13.7 1
lymphoma 10.5 2
inflammation 5.2 3
rheumatoid arthritis 5.19 1

Relevant External Links for ITGB7

Genetic Association Database (GAD)
ITGB7
Human Genome Epidemiology (HuGE) Navigator
ITGB7
genes like me logo Genes that share disorders with ITGB7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ITGB7 Gene

Publications for ITGB7 Gene

  1. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PMID: 2040616) Erle D.J. … Pytela R. (J. Biol. Chem. 1991) 2 3 4 23
  2. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PMID: 1382574) Jiang W.-M. … Krissansen G.W. (Int. Immunol. 1992) 3 4 23
  3. The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PMID: 10837471) Higgins J.M.G. … Brenner M.B. (J. Biol. Chem. 2000) 3 4 23
  4. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PMID: 15663557) Vollmert C. … Wjst M. (Clin. Exp. Allergy 2004) 3 23 48
  5. L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. (PMID: 15699171) Rivera-Nieves J. … Ley K. (J. Immunol. 2005) 3 23

Products for ITGB7 Gene

Sources for ITGB7 Gene

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