Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGB7 Gene

protein-coding GIFtS: 63
GCID: GC12M053585

integrin, beta 7

Explore 39 diseases affiliated with
ITGB7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Beta 7¹ ²
Gut Homing Receptor Beta Subunit² ³
Integrin Beta 7 Subunit²
Integrin Beta-7²

External Ids:	HGNC: 6162¹	Entrez Gene: 3695²	Ensembl: ENSG00000139626⁷	OMIM: 147559⁵	UniProtKB: P26010³

Export aliases for ITGB7 gene to outside databases

Previous GC identifers: GC12M053680 GC12M053498 GC12M053301 GC12M051871 GC12M050628

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates

lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the

cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the

gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes

one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide

L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is

thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin

alpha-E/beta-7 (HML-1) is a receptor for E-cadherin

Gene Wiki entry for ITGB7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGB7 gene promoter:
ER-alpha RP58 Sp1 POU3F1 Pax-2 RelA PPAR-gamma1 c-Myb PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGB7 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGB7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.1

ITGB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB7 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M053585: view genomic region (about GC identifiers)

Start:	53,585,102 bp from pter	End:	53,601,091 bp from pter
Size:	15,990 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010 (See protein sequence)

Recommended Name: Integrin beta-7 precursor

Size: 798 amino acids; 86903 Da

Subunit: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin

alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120

Subcellular location: Membrane; Single-pass type I membrane protein

3 PDB 3D structures from and Proteopedia for ITGB7:

2BRQ (3D)

3V4P (3D)

3V4V (3D)

Secondary accessions: Q9UCP7 Q9UCS7

Alternative splicing: 2 isoforms: P26010-1 P26010-2

Explore the universe of human proteins at neXtProt for ITGB7: NX_P26010

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P26010

ITGB7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000880.1

ENSEMBL proteins:

ENSP00000267082 ENSP00000456446 ENSP00000408741 ENSP00000455374 ENSP00000437375

ENSP00000450366 ENSP00000456305 ENSP00000446703 ENSP00000345501

Reactome Protein details: P26010
Human Recombinant Protein Products for ITGB7:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ITGB7 OriGene Protein Over-expression Lysate: ITGB7 OriGene Custom Protein Services for ITGB7
	GenScript Custom Purified and Recombinant Proteins Services for ITGB7
	Novus Biologicals ITGB7 Proteins Novus Biologicals ITGB7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--

ITGB7 for ontologies About GeneDecksing

ITGB7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB7
	R&D Systems Antibodies for ITGB7 (Integrin beta 7)
	OriGene Antibodies: ITGB7 OriGene Custom Antibody Services for ITGB7
	GenScript Custom Superior Antibodies Services for ITGB7
	Novus Biologicals ITGB7 Antibodies
	Abcam antibodies for ITGB7
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for ITGB7

Assay Products for ITGB7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITGB7
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGB7 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR015437 Integrin_bsu-7

IPR003659 Plexin-like

IPR002369 Integrin_bsu_N

IPR012896 Integrin_bsu_tail

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry P26010

ProtoNet protein and cluster: P26010

3 Blocks protein families:

IPB001169 Integrin beta

IPB002035 Von Willebrand factor type A domain signature

IPB002369 Integrin beta subunit signature

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010

Domain: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent

adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent

binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively

modify ligand binding whereas ADMIDAS negatively modify ligand binding

Similarity: Belongs to the integrin beta chain family

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ITB7_HUMAN, P26010

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates

lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the

cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the

gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes

one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide

L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is

thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin

alpha-E/beta-7 (HML-1) is a receptor for E-cadherin

Induction: Integrin alpha-E/beta-7 is induced by TGFB1

Genatlas biochemistry entry for ITGB7:

integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005102	receptor binding	IEA	--
GO:0046872	metal ion binding	IEA	--

ITGB7 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itgb7):

cellular	digestive/alimentary	embryogenesis	hematopoietic system	immune system
reproductive system	skeleton

ITGB7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Itgb7^tm1Cgn for ITGB7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGB7

miRNA Products:		OriGene 3'-UTR Clone: ITGB7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB7
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGB7
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB7 (see all 4) OriGene shRNA RFP: ITGB7 OriGene siRNA: ITGB7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB7
		Sirion Biotech Custom design and validation of potent shRNA sequences against ITGB7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ITGB7
			Sirion Biotech Customized adenovirus for overexpression of ITGB7 Sirion Biotech Customized adenovirus for potent knockdown of ITGB7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGB7 (NM_000889)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGB7
		Search LifeMap BioReagents cell lines for ITGB7
		Sirion Biotech Customized stable knockdown cell line services for ITGB7 Sirion Biotech Customized inducible knockdown cell line services for ITGB7 Sirion Biotech Customized stable overexpressing cell line services for ITGB7 Sirion Biotech Customized inducible overexpressing cell line services for ITGB7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

Pathway sources
See GeneCards unified pathways
Show all pathways

5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB7 (see all 34)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

5/7 BioSystems Pathways for ITGB7 (see all 7)

	Focal Adhesion
	Integrin-mediated cell adhesion
	Arrhythmogenic right ventricular cardiomyopathy
	a4b1 and a4b7 Integrin signaling
	E-cadherin signaling in the nascent adherens junction

5 Reactome Pathways for ITGB7

	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Signal Transduction
	Adaptive Immune System
	Immune System

5/8 Kegg Pathways (Kegg details for ITGB7) (see all 8):

	Focal adhesion
	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Intestinal immune network for IgA production
	Regulation of actin cytoskeleton

ITGB7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGB7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/129 Interacting proteins for ITGB7 (P26010^{2, 3} ENSP00000267082⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 129)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TENC1	Q63HR2²^,³, ENSP00000319756⁴	MINT-61567 I2D: score=3 STRING: ENSP00000319756
ANKS1B	Q7Z6G8²^,³, ENSP00000331381⁴	MINT-45907 I2D: score=1 STRING: ENSP00000331381
EPS8	Q12929²^,³	MINT-45901 I2D: score=1
MAPK8IP1	Q9UQF2²^,³	MINT-45958 I2D: score=1
RGS12	O14924²^,³	MINT-45915 I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2040616
GO:0007160	cell-matrix adhesion	IEA	--
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0050776	regulation of immune response	TAS	--

ITGB7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGB7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGB7

2 HMDB Compounds for ITGB7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

4 Novoseek chemical compound relationships for ITGB7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
apicidin	71.2	2	15210580 (1), 17258775 (1)
butyrate	38.3	3	15210580 (1), 17258775 (1), 11003451 (1)
paclitaxel	0.628	2	15010891 (1), 15868904 (1)
tyrosine	0	4	8634433 (1), 19843520 (1)

Search CenterWatch for drugs/clinical trials and news about ITGB7 / ITB7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGB7 gene:

NM_000889.1

Unigene Cluster for ITGB7:

Integrin, beta 7

Hs.654470 [show with all ESTs]

Unigene Representative Sequence: NM_000889

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000267082(uc001scc.3) ENST00000551319 ENST00000422257(uc009zmv.3 uc010snz.2)

ENST00000550743 ENST00000542497 ENST00000548706 ENST00000589418 ENST00000548269

ENST00000551887 ENST00000549196 ENST00000589179 ENST00000549462(uc010soa.1)

ENST00000552972 ENST00000552935 ENST00000549086 ENST00000338737

miRNA Products:		OriGene 3'-UTR Clone: ITGB7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB7
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGB7
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB7 (see all 4) OriGene shRNA RFP: ITGB7 OriGene siRNA: ITGB7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB7
		Sirion Biotech Custom design and validation of potent shRNA sequences against ITGB7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGB7 (NM_000889)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB7

Additional cDNA sequence:

AK298239.1 AK300960.1 AK301523.1 AK311703.1 BC015916.1 M62880.1 M68892.1 S80335.1

8 DOTS entries:

DT.209900 DT.40291085 DT.91756272 DT.100752323 DT.100752321 DT.436690 DT.91786022 DT.75196114

24/73 AceView cDNA sequences (see all 73):

BC015916 BP342116 CR610718 BM561674 BQ642465 AI738571 CA449285 AU106028

BP342998 BM564468 CD609752 CD367035 BQ006702 M62880 AL560589 BQ052271

BG744254 BQ052494 BQ054766 AW274583 CD609754 BF510756 AU076872 AA310497

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^
SP1:															-				-		-																								-
SP2:									-						-				-		-																								-
SP3:															-				-		-
SP4:											-				-
SP5:																			-		-

ExUns:	16
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ITGB7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGB7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCAACCT

About this image

ITGB7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITGB7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGB7

SOURCE GeneReport for Unigene cluster: Hs.654470

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010

Tissue specificity: Expressed in a variety of leukocyte lines

SABiosciences Custom PCR Arrays for ITGB7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGB7 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ITGB7⁶	--	55(a)	1 ↔ 1	2(70236531-70263222)
zebrafish (Danio rerio)	Actinopterygii	AL954698.1⁶	--	44(a)	1 ↔ 1	6(39632406-39658106)
fruit fly (Drosophila melanogaster)	Insecta	mys³	central nervous system development calcium-dependent more	35(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	pat-3³	beta integrin	37(a)		III(3981133-3985933) --

ENSEMBL Gene Tree for ITGB7 (if available)
TreeFam Gene Tree for ITGB7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGB7 gene

ITGB4² ITGB1² ENSG00000259753² ITGB2² ITGB3² ITGBL1² ITGB8² ITGB6²

ITGB5²

7 SIMAP similar genes for ITGB7 using alignment to 6 protein entries: ITB7_HUMAN (see all proteins):

ITGB2 ITGB3 ITGB1 ITGB6 ITGB5 ITGB8

ITGB4

ITGB7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185319268^1,2		--	53584643(+)	`GGCTTA/TTCTAC`	2	--	int¹ ut3¹		0	--	--	--	--
rs117955764^1,2	F	--	53584808(+)	`CATCAG/CTTCTG`	2	--	ds500¹ int¹		1		EA	120
rs139168156^1,2		--	53584822(+)	`AAGACA/GAAAAA`	2	--	ds500¹ int¹		0	--	--	--	--
rs11574546^1,2	C,F,H	--	53584871(-)	`GACACT/CGCATC`	2	--	int¹ ds500¹		7		NA NS EA	670
rs17124249^1,2	C,F,H	--	53584919(+)	`AATTCA/GTAGGC`	2	--	int¹ ds500¹		11		NA NS EA WA	1420
rs115553618^1,2	F	--	53584984(+)	`CATTCG/TCGCTT`	2	--	ds500¹ int¹		1		WA	118
rs149509160^1,2		--	53585044(+)	`TTCCCA/GAGGCC`	2	--	int¹ ds500¹		0	--	--	--	--
rs11574545^1,2	C,H	--	53585161(-)	`TGCAAC/ACTTGC`	1	--	ut3¹ ese³		5		NA NS EA	458
rs146038638^1,2		--	53585170(+)	`CAGGCA/GTGGGA`	1	--	ut3¹		0	--	--	--	--
rs4348980^1,2	C,F,A,H	--	53585222(+)	`GTGGCC/TGCACC`	1	--	ut3¹ ese³		7		NS EA NA WA	572

HapMap Linkage Disequilibrium report for ITGB7 (53585102 - 53601091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for ITGB7
8 CNVs: 49091 49090 49096 49094 49089 49095 49092 49093
5 Indels: 11619 11616 11620 11617 11618

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGB7

DNA2.0 Custom Variant and Variant Library Synthesis for ITGB7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGB7 for disorders           About GeneDecksing

OMIM gene information: 147559    OMIM disorders: --

20/39 diseases for ITGB7 (see all 39):    About MalaCards

graft versus host disease spongiotic dermatitis exfoliative ichthyosis non-hodgkin lymphoma

irritable bowel syndrome ankylosing spondylitis hodgkin's lymphoma ichthyosis

inflammatory bowel disease adult t-cell leukemia psoriatic arthritis rheumatoid arthritis

chronic lymphocytic leukemia lymphocytic leukemia ulcerative colitis spondylitis

cutaneous t cell lymphoma encephalomyelitis spondyloarthropathy lymphoblastic lymphoma

7 Novoseek disease relationships for ITGB7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell	29.3	1	9137086 (1)
encephalomyelitis	13.7	1	11114975 (1)
lymphoma	10.5	3	10404404 (1), 8112892 (1)
inflammation	5.2	4	9036954 (2), 15699171 (1)
rheumatoid arthritis	5.19	1	9779846 (1)
necrosis	0	1	11741835 (1)
tumors	0	1	11741835 (1)

Genetic Association Database (GAD): ITGB7
Human Genome Epidemiology (HuGE) Navigator: ITGB7 (1 document)

Export disorders for ITGB7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGB7 gene, integrated from 9 sources (see all 142):
(articles sorted by number of sources associating them with ITGB7)

Utopia: connect your pdf to the dynamic
world of online information

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PubMed id 2040616)^{1, 2, 3, 9} Erle D.J.... Pytela R. (1991)
Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PubMed id 15663557)^{1, 4, 9} Vollmert C....Wjst M. (2004)
The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PubMed id 10837471)^{1, 2, 9} Higgins J.M.G....Brenner M.B. (2000)
The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PubMed id 1382574)^{1, 2, 9} Jiang W.-M....Krissansen G.W. (1992)
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. (PubMed id 18264102)^{1, 2} Arthos J.... Fauci A.S. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 1777426)^{1, 2} Yuan Q.... Watson J.D. (1991)
Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 2083230)^{1, 2} Yuan Q.... Watson J.D. (1990)
A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)^{2, 9} Parker C.M.... Brenner M.B. (1992)
The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)^{1, 9} Rietzler M.... Holzmann B. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3695	HGNC: 6162	AceView: ITGB7	Ensembl:ENSG00000139626	euGenes: HUgn3695
ECgene: ITGB7	Kegg: 3695	H-InvDB: ITGB7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGB7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGB7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGB7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ITGB7 gene:
Search GeneIP for patents involving ITGB7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB7
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for ITGB7 (Integrin beta 7)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ITGB7		OriGene shRNA RFP for ITGB7
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB7
	OriGene Protein Over-expression Lysate for ITGB7		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ITGB7		OriGene 3'-UTR Clone for ITGB7
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ITGB7		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ITGB7		OriGene Custom Protein Services for ITGB7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGB7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGB7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB7

	GenScript Custom Purified and Recombinant Proteins Services for ITGB7		GenScript cDNA clones with any tag delivered in your preferred vector for ITGB7
	GenScript Custom Assay Services for ITGB7		GenScript Custom Superior Antibodies Services for ITGB7
	GenScript Custom overexpressing Cell Line Services for ITGB7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ITGB7 promoter
	Search Chromatin IP Primers for ITGB7
	RT² qPCR Primer Assay in human, mouse, rat ITGB7
	GNC Network for ITGB7
	SABiosciences PCR Arrays including human, mouse, rat ITGB7

Search Tocris compounds for ITGB7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ITGB7 antibodies
	ITGB7 proteins
	ITGB7 lysates

	Antibodies for ITGB7
	See all of Abcam's Antibodies, Kits and Proteins for ITGB7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for ITGB7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB7

	SwitchGear 3'UTR luciferase reporter plasmids for ITGB7
	SwitchGear Promoter luciferase reporter plasmids for ITGB7

Search ThermoFisher Antibodies for ITGB7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGB7

Sirion Biotech Customized:

	stable knockdown cell line services for ITGB7
	inducible knockdown cell line services for ITGB7
	design and validation of potent shRNA sequences against ITGB7
	adenovirus for potent knockdown of ITGB7
	adenovirus for overexpression of ITGB7
	stable overexpressing cell line services for ITGB7
	inducible overexpressing cell line services for ITGB7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ITGB7 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ITGB7 Gene

integrin, beta 7

Aliases
for ITGB7 gene

Summaries
for ITGB7 gene

Genomic Views
for ITGB7 gene

Proteins
for ITGB7 gene

Protein Domains /
Families
for ITGB7 gene

Function
for ITGB7 gene

Pathways & Interactions
for ITGB7 gene

Drugs & Compounds
for ITGB7 gene

Transcripts
for ITGB7 gene

Expression
for ITGB7 gene

Orthologs
for ITGB7 gene

Paralogs
for ITGB7 gene

Genomic Variants
for ITGB7 gene

Disorders / Diseases
for ITGB7 gene

Publications
for ITGB7 gene

External Searches for ITGB7 gene

Genome Databases showing ITGB7 gene

Other Databases showing ITGB7 gene

Specialized Databases showing ITGB7 gene

Intellectual Property
for ITGB7 gene

Products
for ITGB7 gene

View Random Gene

Advanced Search

Export list of displayed genes

ITGB7 Gene

integrin, beta 7

Aliasesfor ITGB7 gene

Summariesfor ITGB7 gene

Genomic Viewsfor ITGB7 gene

Proteinsfor ITGB7 gene

Protein Domains /Familiesfor ITGB7 gene

Functionfor ITGB7 gene

Pathways & Interactionsfor ITGB7 gene

Drugs & Compoundsfor ITGB7 gene

Transcriptsfor ITGB7 gene

Expression for ITGB7 gene

Orthologsfor ITGB7 gene

Paralogsfor ITGB7 gene

Genomic Variantsfor ITGB7 gene

Disorders / Diseasesfor ITGB7 gene

Publicationsfor ITGB7 gene

External Searches for ITGB7 gene

Genome Databases showing ITGB7 gene

Other Databases showing ITGB7 gene

Specialized Databases showing ITGB7 gene

Intellectual Propertyfor ITGB7 gene

Productsfor ITGB7 gene

View Random Gene

Aliases
for ITGB7 gene

Summaries
for ITGB7 gene

Genomic Views
for ITGB7 gene

Proteins
for ITGB7 gene

Protein Domains /
Families
for ITGB7 gene

Function
for ITGB7 gene

Pathways & Interactions
for ITGB7 gene

Drugs & Compounds
for ITGB7 gene

Transcripts
for ITGB7 gene

Expression
for ITGB7 gene

Orthologs
for ITGB7 gene

Paralogs
for ITGB7 gene

Genomic Variants
for ITGB7 gene

Disorders / Diseases
for ITGB7 gene

Publications
for ITGB7 gene

Intellectual Property
for ITGB7 gene

Products
for ITGB7 gene