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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGB7 Gene

protein-coding   GIFtS: 63
GCID: GC12M053585

Integrin, Beta 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Beta 71 2
Gut Homing Receptor Beta Subunit2 3
Integrin Beta 7 Subunit2
Integrin Beta-72

External Ids:    HGNC: 61621   Entrez Gene: 36952   Ensembl: ENSG000001396267   OMIM: 1475595   UniProtKB: P260103   

Export aliases for ITGB7 gene to outside databases

Previous GC identifers: GC12M053680 GC12M053498 GC12M053301 GC12M051871 GC12M050628


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGB7 Gene:
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion
receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric
integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an
alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing
receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE
permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing
results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have
been described, but their full-length nature is not known. (provided by RefSeq, Sep 2013)

GeneCards Summary for ITGB7 Gene: 
ITGB7 (integrin, beta 7) is a protein-coding gene. Diseases associated with ITGB7 include spongiotic dermatitis, and exfoliative ichthyosis, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include receptor activity and receptor binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that
mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7
interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular
endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix
component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin.
Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby
allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would
involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin

Gene Wiki entry for ITGB7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGB7 gene promoter:
         ER-alpha   RP58   Sp1   POU3F1   Pax-2   RelA   PPAR-gamma1   c-Myb   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGB7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGB7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

ITGB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053585:  view genomic region     (about GC identifiers)

Start:
53,585,102 bp from pter      End:
53,601,091 bp from pter
Size:
15,990 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010 (See protein sequence)
Recommended Name: Integrin beta-7 precursor  
Size: 798 amino acids; 86903 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin
alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for ITGB7:
2BRQ (3D)        3V4P (3D)        3V4V (3D)    
Secondary accessions: Q9UCP7 Q9UCS7
Alternative splicing: 2 isoforms:  P26010-1   P26010-2   

Explore the universe of human proteins at neXtProt for ITGB7: NX_P26010

Explore proteomics data for ITGB7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26010

  • ITGB7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGB7 Protein Expression
    REFSEQ proteins: NP_000880.1  
    ENSEMBL proteins: 
     ENSP00000267082   ENSP00000456446   ENSP00000408741   ENSP00000455374   ENSP00000437375  
     ENSP00000450366   ENSP00000456305   ENSP00000446703   ENSP00000345501  
    Reactome Protein details: P26010
    Human Recombinant Protein Products for ITGB7: 
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    Novus Biologicals ITGB7 Proteins
    Novus Biologicals ITGB7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0016020membrane ----

    ITGB7 for ontologies           About GeneDecksing



    ITGB7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB7
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    Abcam antibodies for ITGB7
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ITG: Integrins

    5/9 InterPro protein domains (see all 9):
     IPR015437 Integrin_bsu-7
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P26010

    ProtoNet protein and cluster: P26010

    3 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
    Domain: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal
    ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in
    calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal
    ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    ITGB7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB7_HUMAN, P26010
    Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that
    mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7
    interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular
    endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix
    component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin.
    Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby
    allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would
    involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin
    Induction: Integrin alpha-E/beta-7 is induced by TGFB1

         Genatlas biochemistry entry for ITGB7:
    integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI17690686
    GO:0046872metal ion binding IEA--
         
    ITGB7 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb7):
     cellular  digestive/alimentary  embryogenesis  hematopoietic system  immune system 
     reproductive system  skeleton 

    ITGB7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itgb7tm1Cgn for ITGB7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGB7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGB7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGB7 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidITGB7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGB7 About   (see all 28)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB7 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    5/7 BioSystems Pathways for ITGB7 (see all 7)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    E-cadherin signaling in the nascent adherens junction
    Paxillin-dependent events mediated by a4b1


    5        Reactome Pathways for ITGB7
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System
    Immune System


    5/10         Kegg Pathways  (Kegg details for ITGB7) (see all 10):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Intestinal immune network for IgA production


    ITGB7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGB7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/130 Interacting proteins for ITGB7 (P260102, 3 ENSP000002670824) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TENC1Q63HR22, 3, ENSP000003197564MINT-61567 I2D: score=3 STRING: ENSP00000319756
    EPS8Q129292, 3MINT-45901 I2D: score=1 
    MAPK8IP1Q9UQF22, 3MINT-45958 I2D: score=1 
    RGS12O149242, 3MINT-45915 I2D: score=1 
    FLNAP213332, 3, ENSP000003588664MINT-5226910 MINT-5226942 MINT-51374 MINT-5226916 MINT-5226955 MINT-5226895 MINT-5226997 I2D: score=4 STRING: ENSP00000358866
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS2040616
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0050776regulation of immune response TAS--

    ITGB7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGB7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGB7 (ITB7)

    2 HMDB Compounds for ITGB7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for ITGB7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apicidin 71.2 2 15210580 (1), 17258775 (1)
    butyrate 38.3 3 15210580 (1), 17258775 (1), 11003451 (1)
    paclitaxel 0.628 2 15010891 (1), 15868904 (1)
    tyrosine 0 4 8634433 (1), 19843520 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGB7 / ITB7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGB7 gene: 
    NM_000889.2  

    Unigene Cluster for ITGB7:

    Integrin, beta 7
    Hs.654470  [show with all ESTs]
    Unigene Representative Sequence: NM_000889
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267082(uc001scc.3) ENST00000551319 ENST00000422257(uc009zmv.3 uc010snz.2)
    ENST00000550743 ENST00000542497 ENST00000548706 ENST00000548269 ENST00000551887
    ENST00000549196 ENST00000589179 ENST00000549462(uc010soa.1) ENST00000552972
    ENST00000552935 ENST00000549086 ENST00000338737
    miRNA
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    Additional mRNA sequence: 

    AK298239.1 AK300960.1 AK301523.1 AK311703.1 BC015916.1 M62880.1 M68892.1 S80335.1 

    8 DOTS entries:

    DT.209900  DT.40291085  DT.91756272  DT.100752323  DT.100752321  DT.436690  DT.91786022  DT.75196114 

    24/73 AceView cDNA sequences (see all 73):

    BQ006702 BG744254 M62880 BP342998 AI738571 BQ052271 BP342116 AL560589 
    CR610718 CD609752 BQ052494 BC015916 BM564468 AU106028 BQ054766 CA449285 
    BQ642465 CD367035 BM561674 CD609754 BE242561 BF510756 M68892 BX372468 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
    SP1:                                            -           -     -                                                                       -                     
    SP2:                          -                 -           -     -                                                                       -                     
    SP3:                                            -           -     -                                                                                             
    SP4:                                -           -                                                                                                               
    SP5:                                                        -     -                                                                                             

    ExUns: 16
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ITGB7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGB7 expression in normal human tissues (normalized intensities)      ITGB7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCAACCT
    ITGB7 Expression
    About this image


    ITGB7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Mast cell progenitor cells Hematopoietic Bone Marrow
             Peripheral blood Pan-T Cells   
             BONE MARROW   
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)

    See ITGB7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGB7

    SOURCE GeneReport for Unigene cluster: Hs.654470

    UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
    Tissue specificity: Expressed in a variety of leukocyte lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGB7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb71 , 5 integrin beta 71, 5 84.23(n)1
    86.45(a)1
      15 (57.39 cM)5
    164211  NM_013566.21  NP_038594.21 
     1022159955 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB76
    integrin, beta 7
    54(a)
    1 ↔ 1
    2(70224983-70276130)
    zebrafish
    (Danio rerio)
    Actinopterygii AL954698.16
    Integrin beta
    43(a)
    1 ↔ 1
    6(39632406-39658106)
    fruit fly
    (Drosophila melanogaster)
    Insecta mys3 central nervous system development
    calcium-dependent more
    35(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea pat-33 beta integrin 37(a)   III(3981133-3985933)   --


    ENSEMBL Gene Tree for ITGB7 (if available)
    TreeFam Gene Tree for ITGB7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGB7 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB22  ITGBL12  ITGB32  ITGB82  ITGB62  
    ITGB52  
    7 SIMAP similar genes for ITGB7 using alignment to 6 protein entries:     ITB7_HUMAN (see all proteins):
    ITGB2    ITGB3    ITGB5    ITGB1    ITGB6    ITGB8
    ITGB4

    ITGB7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/519 SNPs in ITGB7 are shown (see all 519)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115745451,2
    C,H--53585161(-) TGCAAC/ACTTGC 1 -- ut31 ese35Minor allele frequency- A:0.00NA NS EA 458
    rs1460386381,2
    C--53585170(+) CAGGCA/GTGGGA 1 -- ut310--------
    rs43489801,2
    C,F,A,H--53585222(+) GTGGCC/TGCACC 1 -- ut31 ese37Minor allele frequency- T:0.07NS EA NA WA 572
    rs1909135891,2
    --53585269(+) ACCCAC/TCCTTC 1 -- ut310--------
    rs802014701,2
    C--53585278(+) TCCTCT/CCACCC 1 -- ut312Minor allele frequency- C:0.14CSA WA 120
    rs1161700011,2
    C,F--53585337(+) TCCCTC/TCTTCA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1416105541,2
    C,F--53585372(+) AAAGCG/AAGGAT 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5825
    rs1509103451,2
    C,F--53585388(+) GTGGTC/TGTGAT 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs2000249201,2
    --53585398(+) TGGCAC/TTTTTG 2 N S mis10--------
    rs1399626601,2
    --53585546(+) GTTACA/GTGTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGB7 (53585102 - 53601091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ITGB7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv52860CNV Loss16902084
    dgv27n6CNV Loss16902084
    nsv469404CNV Loss19166990
    nsv52501CNV Loss16902084
    nsv517066CNV Loss19592680
    nsv52510CNV Loss16902084
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147559    OMIM disorders: --

    20/39 diseases for ITGB7 (see all 39):    About MalaCards
    spongiotic dermatitis    exfoliative ichthyosis    lymphoblastic lymphoma    irritable bowel syndrome
    spondyloarthropathy    hiv type 1    acute graft versus host disease    psoriatic arthritis
    hematopoietic stem cell transplantation    ichthyosis    adult t-cell leukemia    cutaneous t cell lymphoma
    graft versus host disease    ankylosing spondylitis    encephalomyelitis    tonsillitis
    spondylitis    b-cell chronic lymphocytic leukemia    multiple myeloma    crohn's disease


    ITGB7 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for ITGB7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 29.3 1 9137086 (1)
    encephalomyelitis 13.7 1 11114975 (1)
    lymphoma 10.5 3 10404404 (1), 8112892 (1)
    inflammation 5.2 4 9036954 (2), 15699171 (1)
    rheumatoid arthritis 5.19 1 9779846 (1)
    necrosis 0 1 11741835 (1)
    tumors 0 1 11741835 (1)

    Genetic Association Database (GAD): ITGB7
    Human Genome Epidemiology (HuGE) Navigator: ITGB7 (1 document)

    Export disorders for ITGB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGB7 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with ITGB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PubMed id 2040616)1, 2, 3, 9 Erle D.J.... Pytela R. (1991)
    2. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PubMed id 15663557)1, 4, 9 Vollmert C....Wjst M. (2004)
    3. The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PubMed id 10837471)1, 2, 9 Higgins J.M.G....Brenner M.B. (2000)
    4. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PubMed id 1382574)1, 2, 9 Jiang W.-M....Krissansen G.W. (1992)
    5. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. (PubMed id 18264102)1, 2 Arthos J.... Fauci A.S. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 1777426)1, 2 Yuan Q.... Watson J.D. (1991)
    8. Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 2083230)1, 2 Yuan Q.... Watson J.D. (1990)
    9. A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)2, 9 Parker C.M.... Brenner M.B. (1992)
    10. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)1, 9 Rietzler M.... Holzmann B. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3695 HGNC: 6162 AceView: ITGB7 Ensembl:ENSG00000139626 euGenes: HUgn3695
    ECgene: ITGB7 Kegg: 3695 H-InvDB: ITGB7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGB7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGB7 gene:
    Search GeneIP for patents involving ITGB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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