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Aliases for ITGB7 Gene

Aliases for ITGB7 Gene

  • Integrin Subunit Beta 7 2 3 5
  • Gut Homing Receptor Beta Subunit 4
  • Integrin, Beta 7 2

External Ids for ITGB7 Gene

Previous GeneCards Identifiers for ITGB7 Gene

  • GC12M053680
  • GC12M053498
  • GC12M053301
  • GC12M051871
  • GC12M053585
  • GC12M050628

Summaries for ITGB7 Gene

Entrez Gene Summary for ITGB7 Gene

  • This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for ITGB7 Gene

ITGB7 (Integrin Subunit Beta 7) is a Protein Coding gene. Diseases associated with ITGB7 include exfoliative ichthyosis and hiv-1. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Degradation of the extracellular matrix. GO annotations related to this gene include receptor activity and virus receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB7 Gene

  • Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Gene Wiki entry for ITGB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB7 Gene

Genomics for ITGB7 Gene

Regulatory Elements for ITGB7 Gene

Promoters for ITGB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGB7 Gene

Chromosome:
12
Start:
53,191,318 bp from pter
End:
53,207,310 bp from pter
Size:
15,993 bases
Orientation:
Minus strand

Genomic View for ITGB7 Gene

Genes around ITGB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB7 Gene

Proteins for ITGB7 Gene

  • Protein details for ITGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26010-ITB7_HUMAN
    Recommended name:
    Integrin beta-7
    Protein Accession:
    P26010
    Secondary Accessions:
    • Q9UCP7
    • Q9UCS7

    Protein attributes for ITGB7 Gene

    Size:
    798 amino acids
    Molecular mass:
    86903 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM1, fibronectin, and may also interact with HIV-1 gp120. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450).

    Three dimensional structures from OCA and Proteopedia for ITGB7 Gene

    Alternative splice isoforms for ITGB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB7 Gene

Proteomics data for ITGB7 Gene at MOPED

Post-translational modifications for ITGB7 Gene

  • Glycosylation at Asn 68, Asn 279, Asn 434, Asn 477, Asn 531, Asn 590, Asn 665, and Asn 674
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ITGB7 (Integrin beta 7)

No data available for DME Specific Peptides for ITGB7 Gene

Domains & Families for ITGB7 Gene

Gene Families for ITGB7 Gene

Suggested Antigen Peptide Sequences for ITGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P26010

UniProtKB/Swiss-Prot:

ITB7_HUMAN :
  • Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • Belongs to the integrin beta chain family.
Domain:
  • Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB7: view

Function for ITGB7 Gene

Molecular function for ITGB7 Gene

GENATLAS Biochemistry:
integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
UniProtKB/Swiss-Prot Function:
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
UniProtKB/Swiss-Prot Induction:
Integrin alpha-E/beta-7 is induced by TGFB1.

Gene Ontology (GO) - Molecular Function for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050839 cell adhesion molecule binding IMP 23986478
genes like me logo Genes that share ontologies with ITGB7: view
genes like me logo Genes that share phenotypes with ITGB7: view

Animal Models for ITGB7 Gene

MGI Knock Outs for ITGB7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGB7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITGB7 Gene

Localization for ITGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB7 Gene COMPARTMENTS Subcellular localization image for ITGB7 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034669 integrin alpha4-beta7 complex IDA 18308860
genes like me logo Genes that share ontologies with ITGB7: view

Pathways & Interactions for ITGB7 Gene

genes like me logo Genes that share pathways with ITGB7: view

SIGNOR curated interactions for ITGB7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2040616
GO:0007160 cell-matrix adhesion IEA,IMP 18308860
GO:0034113 heterotypic cell-cell adhesion IMP 18308860
GO:0034446 substrate adhesion-dependent cell spreading IMP 23986478
GO:0043113 receptor clustering IMP 23986478
genes like me logo Genes that share ontologies with ITGB7: view

Drugs & Compounds for ITGB7 Gene

(8) Drugs for ITGB7 Gene - From: HMDB, Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vedolizumab Approved Pharma Target, antibody 37
R1295 Investigational Pharma antagonist, Target 0
MLN-02 Investigational Pharma Target 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for ITGB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGB7: view

Transcripts for ITGB7 Gene

Unigene Clusters for ITGB7 Gene

Integrin, beta 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7:

ExUns: 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ITGB7 Gene

GeneLoc Exon Structure for
ITGB7
ECgene alternative splicing isoforms for
ITGB7

Expression for ITGB7 Gene

mRNA expression in normal human tissues for ITGB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB7 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for ITGB7 Gene

This gene is overexpressed in Pancreas (23.1), Peripheral blood mononuclear cells (14.9), and CD8 Tcells (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGB7 Gene



SOURCE GeneReport for Unigene cluster for ITGB7 Gene Hs.654470

mRNA Expression by UniProt/SwissProt for ITGB7 Gene

P26010-ITB7_HUMAN
Tissue specificity: Expressed in a variety of leukocyte lines.
genes like me logo Genes that share expression patterns with ITGB7: view

Protein tissue co-expression partners for ITGB7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ITGB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB7 35
  • 99.54 (n)
  • 99.75 (a)
ITGB7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGB7 36
  • 87 (a)
OneToOne
ITGB7 35
  • 87.68 (n)
  • 87.59 (a)
dog
(Canis familiaris)
Mammalia ITGB7 35
  • 86.93 (n)
  • 88.6 (a)
ITGB7 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb7 36
  • 85 (a)
OneToOne
Itgb7 16
Itgb7 35
  • 84.46 (n)
  • 87.2 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB7 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb7 35
  • 84.64 (n)
  • 87.07 (a)
lizard
(Anolis carolinensis)
Reptilia ITGB7 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itgb7 35
  • 57.79 (n)
  • 55.3 (a)
zebrafish
(Danio rerio)
Actinopterygii itgb7 36
  • 44 (a)
OneToOne
LOC797491 35
  • 53.18 (n)
  • 46.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta mys 36
  • 34 (a)
OneToMany
bgrInt-ngr 37
  • 30 (a)
mys 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 36
  • 36 (a)
OneToMany
pat-3 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.871 36
  • 34 (a)
OneToMany
Species with no ortholog for ITGB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB7 Gene

ENSEMBL:
Gene Tree for ITGB7 (if available)
TreeFam:
Gene Tree for ITGB7 (if available)

Paralogs for ITGB7 Gene

(7) SIMAP similar genes for ITGB7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ITGB7: view

Variants for ITGB7 Gene

Sequence variations from dbSNP and Humsavar for ITGB7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11539433 - 53,192,471(-) GTGCC(C/T)ATACC nc-transcript-variant, reference, missense
rs869445 -- 53,194,860(+) TCTTG(A/T)GAAGA intron-variant
rs2230397 -- 53,192,414(-) AAGAG(A/C/T)GGACC nc-transcript-variant, reference, synonymous-codon
rs2272299 -- 53,193,038(+) ACACC(A/G)GAATC intron-variant
rs2272300 -- 53,193,684(+) GGTGG(G/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB7 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv469404 CNV Loss 19166990
nsv52510 CNV Loss 16902084
dgv27n6 CNV Loss 16902084
nsv52860 CNV Loss 16902084
nsv52501 CNV Loss 16902084

Variation tolerance for ITGB7 Gene

Residual Variation Intolerance Score: 6.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGB7 Gene

HapMap Linkage Disequilibrium report
ITGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB7 Gene

Disorders for ITGB7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITGB7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search ITGB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGB7

Genetic Association Database (GAD)
ITGB7
Human Genome Epidemiology (HuGE) Navigator
ITGB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGB7
genes like me logo Genes that share disorders with ITGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB7 Gene

Publications for ITGB7 Gene

  1. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PMID: 2040616) Erle D.J. … Pytela R. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. (PMID: 17490615) Monteiro P. … Fardel O. (Biochem. Biophys. Res. Commun. 2007) 3 23
  3. A pseudosymmetric cell adhesion regulatory domain in the beta7 tail of the integrin alpha4beta7 that interacts with focal adhesion kinase and src. (PMID: 16874740) Krissansen G.W. … Yang Y. (Eur. J. Immunol. 2006) 3 23
  4. L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. (PMID: 15699171) Rivera-Nieves J. … Ley K. (J. Immunol. 2005) 3 23
  5. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PMID: 15663557) Vollmert C. … Wjst M. (Clin. Exp. Allergy 2004) 3 23

Products for ITGB7 Gene

Sources for ITGB7 Gene

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