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ITGB7 Gene

protein-coding   GIFtS: 63
GCID: GC12M053585

Integrin, Beta 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Beta 71 2
Gut Homing Receptor Beta Subunit2 3
Integrin Beta 7 Subunit2
Integrin Beta-72

External Ids:    HGNC: 61621   Entrez Gene: 36952   Ensembl: ENSG000001396267   OMIM: 1475595   UniProtKB: P260103   

Export aliases for ITGB7 gene to outside databases

Previous GC identifers: GC12M053680 GC12M053498 GC12M053301 GC12M051871 GC12M050628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGB7 Gene:
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion
receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric
integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an
alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing
receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE
permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing
results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have
been described, but their full-length nature is not known. (provided by RefSeq, Sep 2013)

GeneCards Summary for ITGB7 Gene:
ITGB7 (integrin, beta 7) is a protein-coding gene. Diseases associated with ITGB7 include spongiotic dermatitis, and lymphoblastic lymphoma. GO annotations related to this gene include virus receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that
mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7
interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular
endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix
component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin.
Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby
allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would
involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin

Gene Wiki entry for ITGB7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGB7 gene promoter:
         ER-alpha   RP58   Sp1   POU3F1   Pax-2   RelA   PPAR-gamma1   c-Myb   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGB7 promoter sequence
   Search Chromatin IP Primers for ITGB7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

ITGB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053585:  view genomic region     (about GC identifiers)

Start:
53,585,102 bp from pter      End:
53,601,091 bp from pter
Size:
15,990 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010 (See protein sequence)
Recommended Name: Integrin beta-7 precursor  
Size: 798 amino acids; 86903 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin
alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120
3 PDB 3D structures from and Proteopedia for ITGB7:
2BRQ (3D)        3V4P (3D)        3V4V (3D)    
Secondary accessions: Q9UCP7 Q9UCS7
Alternative splicing: 2 isoforms:  P26010-1   P26010-2   

Explore the universe of human proteins at neXtProt for ITGB7: NX_P26010

Explore proteomics data for ITGB7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn68, Asn279, Asn434, Asn477, Asn531, Asn590, Asn665, Asn674
  • Modification sites at PhosphoSitePlus

  • See ITGB7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000880.1  
    ENSEMBL proteins: 
     ENSP00000267082   ENSP00000456446   ENSP00000408741   ENSP00000455374   ENSP00000437375  
     ENSP00000450366   ENSP00000456305   ENSP00000446703   ENSP00000345501  
    Reactome Protein details: P26010

    ITGB7 Human Recombinant Protein Products:

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    Novus Biologicals ITGB7 Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGB7 Antibody Products:

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    Novus Biologicals ITGB7 Antibodies
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    Browse ELISAs at Cloud-Clone Corp.
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    Selected InterPro protein domains (see all 7):
     IPR015437 Integrin_bsu-7
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P26010

    ProtoNet protein and cluster: P26010

    3 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
    Domain: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal
    ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in
    calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal
    ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    ITGB7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB7_HUMAN, P26010
    Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that
    mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7
    interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular
    endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix
    component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin.
    Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby
    allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would
    involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin
    Induction: Integrin alpha-E/beta-7 is induced by TGFB1

         Genatlas biochemistry entry for ITGB7:
    integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI17690686
    GO:0046872metal ion binding IEA--
         
    ITGB7 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb7):
     cellular  digestive/alimentary  embryogenesis  hematopoietic system  immune system 
     reproductive system  skeleton 

    ITGB7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itgb7tm1Cgn for ITGB7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGB7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGB7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGB7

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ITGB7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ITGB7 (NM_000889)
    Sino Biological Human cDNA Clone for ITGB7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITB7_HUMAN, P26010: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS2040616
    GO:0016020membrane ----
    GO:0043235receptor complex IDA--
    GO:0070062extracellular vesicular exosome IDA--

    ITGB7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGB7 About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGB7 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    Selected BioSystems Pathways for ITGB7 (see all 7)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    a4b1 and a4b7 Integrin signaling
    E-cadherin signaling in the nascent adherens junction


    2 Reactome Pathways for ITGB7
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for ITGB7) (see all 10):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Intestinal immune network for IgA production


    ITGB7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITGB7
    Interactions:

        GeneGlobe Interaction Network for ITGB7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGB7 (P260101, 2, 3 ENSP000002670824) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNAP213331, 2, 3, ENSP000003588664EBI-702932,EBI-350432 MINT-5226910 MINT-5226942 MINT-51374 MINT-5226916 MINT-5226955 MINT-5226895 MINT-5226997 I2D: score=4 STRING: ENSP00000358866
    TENC1Q63HR22, 3, ENSP000003197564MINT-61567 I2D: score=3 STRING: ENSP00000319756
    EPS8Q129292, 3MINT-45901 I2D: score=1 
    MAPK8IP1Q9UQF22, 3MINT-45958 I2D: score=1 
    RGS12O149242, 3MINT-45915 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007160cell-matrix adhesion ----
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030198extracellular matrix organization TAS--

    ITGB7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGB7 (ITB7)

    2 HMDB Compounds for ITGB7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for ITGB7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apicidin 71.2 2 15210580 (1), 17258775 (1)
    butyrate 38.3 3 15210580 (1), 17258775 (1), 11003451 (1)
    paclitaxel 0.628 2 15010891 (1), 15868904 (1)
    tyrosine 0 4 8634433 (1), 19843520 (1)



    ITGB7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITGB7 gene: 
    NM_000889.2  

    Unigene Cluster for ITGB7:

    Integrin, beta 7
    Hs.654470  [show with all ESTs]
    Unigene Representative Sequence: NM_000889
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267082(uc001scc.3) ENST00000551319 ENST00000422257(uc009zmv.3 uc010snz.2)
    ENST00000550743 ENST00000542497 ENST00000548706 ENST00000548269 ENST00000551887
    ENST00000549196 ENST00000589179 ENST00000549462(uc010soa.1) ENST00000552972
    ENST00000552935 ENST00000549086 ENST00000338737
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ITGB7

    Additional mRNA sequence: 

    AK298239.1 AK300960.1 AK301523.1 AK311703.1 BC015916.1 M62880.1 M68892.1 S80335.1 

    8 DOTS entries:

    DT.209900  DT.40291085  DT.91756272  DT.100752323  DT.100752321  DT.436690  DT.91786022  DT.75196114 

    Selected AceView cDNA sequences (see all 73):

    CD367035 AL560589 CR610718 BP342998 CD609752 BM564468 BQ006702 BQ052271 
    AI738571 AU106028 BM561674 BQ054766 BQ642465 BC015916 BG744254 BP342116 
    M62880 CA449285 BQ052494 BG468184 BX404999 CD609754 BF510756 NM_000889 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
    SP1:                                            -           -     -                                                                       -                     
    SP2:                          -                 -           -     -                                                                       -                     
    SP3:                                            -           -     -                                                                                             
    SP4:                                -           -                                                                                                               
    SP5:                                                        -     -                                                                                             

    ExUns: 16
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ITGB7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGB7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCAACCT
    ITGB7 Expression
    About this image


    ITGB7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Mast cell progenitor cells Hematopoietic Bone Marrow
             CD19+ B Cells   
             BONE MARROW   
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
    ITGB7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGB7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654470

    UniProtKB/Swiss-Prot: ITB7_HUMAN, P26010
    Tissue specificity: Expressed in a variety of leukocyte lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ITGB7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb71 , 5 integrin beta 71, 5 84.46(n)1
    87.2(a)1
      15 (57.39 cM)5
    164211  NM_013566.21  NP_038594.21 
     1022159955 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB76
    integrin, beta 7
    55(a)
    1 ↔ 1
    2(70224983-70276130)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itgb71 integrin, beta 7 57.79(n)
    55.3(a)
      100486332  XM_002936640.2  XP_002936686.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7974911 integrin beta-7-like 53.18(n)
    46.31(a)
      797491  XM_001337913.3  XP_001337949.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta mys3 central nervous system development
    calcium-dependent more
    35(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea pat-33 beta integrin 37(a)   III(3981133-3985933)   --


    ENSEMBL Gene Tree for ITGB7 (if available)
    TreeFam Gene Tree for ITGB7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGB7 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB22  ITGBL12  ITGB32  ITGB82  ITGB62  
    ITGB52  
    7 SIMAP similar genes for ITGB7 using alignment to 6 protein entries:     ITB7_HUMAN (see all proteins):
    ITGB2    ITGB3    ITGB5    ITGB1    ITGB6    ITGB8
    ITGB4

    ITGB7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGB7 (see all 519)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115745451,2
    C,H--53585161(-) TGCAAC/ACTTGC 1 -- ut31 ese35Minor allele frequency- A:0.00NA NS EA 458
    rs1460386381,2
    C--53585170(+) CAGGCA/GTGGGA 1 -- ut310--------
    rs43489801,2
    C,F,A,H--53585222(+) GTGGCC/TGCACC 1 -- ut31 ese37Minor allele frequency- T:0.07NS EA NA WA 572
    rs1909135891,2
    --53585269(+) ACCCAC/TCCTTC 1 -- ut310--------
    rs802014701,2
    C--53585278(+) TCCTCT/CCACCC 1 -- ut312Minor allele frequency- C:0.14CSA WA 120
    rs1161700011,2
    C,F--53585337(+) TCCCTC/TCTTCA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1416105541,2
    C,F--53585372(+) AAAGCG/AAGGAT 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5825
    rs1509103451,2
    C,F--53585388(+) GTGGTC/TGTGAT 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs2000249201,2
    --53585398(+) TGGCAC/TTTTTG 2 N S mis10--------
    rs1399626601,2
    --53585546(+) GTTACA/GTGTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGB7 (53585102 - 53601091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ITGB7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv52860CNV Loss16902084
    dgv27n6CNV Loss16902084
    nsv469404CNV Loss19166990
    nsv52501CNV Loss16902084
    nsv517066CNV Loss19592680
    nsv52510CNV Loss16902084
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147559    OMIM disorders: --

    Selected diseases for ITGB7 (see all 38):    
    About MalaCards
    spongiotic dermatitis    lymphoblastic lymphoma    irritable bowel syndrome    spondyloarthropathy
    acute graft versus host disease    psoriatic arthritis    hematopoietic stem cell transplantation    adult t-cell leukemia
    cutaneous t cell lymphoma    graft versus host disease    encephalomyelitis    b-cell chronic lymphocytic leukemia
    ankylosing spondylitis    spondylitis    tonsillitis    hypertrophic cardiomyopathy
    crohn's disease    chronic lymphocytic leukemia    multiple myeloma    gastritis


    ITGB7 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for ITGB7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 29.3 1 9137086 (1)
    encephalomyelitis 13.7 1 11114975 (1)
    lymphoma 10.5 3 10404404 (1), 8112892 (1)
    inflammation 5.2 4 9036954 (2), 15699171 (1)
    rheumatoid arthritis 5.19 1 9779846 (1)
    necrosis 0 1 11741835 (1)
    tumors 0 1 11741835 (1)

    Genetic Association Database (GAD): ITGB7
    Human Genome Epidemiology (HuGE) Navigator: ITGB7 (1 document)

    Export disorders for ITGB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGB7 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with ITGB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PubMed id 2040616)1, 2, 3, 9 Erle D.J.... Pytela R. (J. Biol. Chem. 1991)
    2. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PubMed id 15663557)1, 4, 9 Vollmert C....Wjst M. (Clin. Exp. Allergy 2004)
    3. The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PubMed id 10837471)1, 2, 9 Higgins J.M.G....Brenner M.B. (J. Biol. Chem. 2000)
    4. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PubMed id 1382574)1, 2, 9 Jiang W.-M....Krissansen G.W. (Int. Immunol. 1992)
    5. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. (PubMed id 18264102)1, 2 Arthos J.... Fauci A.S. (Nat. Immunol. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 1777426)1, 2 Yuan Q.... Watson J.D. (Int. Immunol. 1991)
    8. Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. (PubMed id 2083230)1, 2 Yuan Q.... Watson J.D. (Int. Immunol. 1990)
    9. A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)2, 9 Parker C.M.... Brenner M.B. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)1, 9 Rietzler M.... Holzmann B. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3695 HGNC: 6162 AceView: ITGB7 Ensembl:ENSG00000139626 euGenes: HUgn3695
    ECgene: ITGB7 Kegg: 3695 H-InvDB: ITGB7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGB7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ITGB7 gene:
    Search GeneIP for patents involving ITGB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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