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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGB6 Gene

protein-coding   GIFtS: 60
GCID: GC02M160920

integrin, beta 6

 Explore 21 diseases affiliated with
ITGB6 via our new
 Human Malady Compendium 
Biological research products
for ITGB6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Integrin, Beta 61 2
Integrin Beta-62

External Ids:    HGNC: 61611   Entrez Gene: 36942   Ensembl: ENSG000001152217   OMIM: 1475585   UniProtKB: P185643   

Export aliases for ITGB6 gene to outside databases

Previous GC identifers: GC02M158889 GC02M159484 GC02M161158 GC02M160781 GC02M160664 GC02M152841


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITB6_HUMAN, P18564
Function: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its
ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion

Gene Wiki entry for ITGB6 (Integrin, beta 6)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGB6 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   Nkx2-5   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGB6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGB6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

ITGB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M160920:  view genomic region     (about GC identifiers)

Start:
160,956,177 bp from pter      End:
161,128,399 bp from pter
Size:
172,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITB6_HUMAN, P18564 (See protein sequence)
Recommended Name: Integrin beta-6 precursor  
Size: 788 amino acids; 85936 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts
with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus
B1 capsid proteins and acts as a receptor for these viruses
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ITGB6:
1LH9 (3D)    
Secondary accessions: B2R9W5 Q0VA95 Q16500 Q53RG5 Q53RR6

Explore the universe of human proteins at neXtProt for ITGB6: NX_P18564

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18564

  • ITGB6 Protein expression data from MOPED and PaxDb:    About this image 
    ITGB6 Protein Expression
    REFSEQ proteins: NP_000879.2  
    ENSEMBL proteins: 
     ENSP00000283249   ENSP00000386477   ENSP00000408024   ENSP00000386828   ENSP00000386367  
    Reactome Protein details: P18564
    Human Recombinant Protein Products for ITGB6: 
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    Novus Biologicals ITGB6 Proteins
    Novus Biologicals ITGB6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--

    ITGB6 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ITGB6 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR003659 Plexin-like
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR016201 Plexin-like_fold
     IPR013111 EGF_extracell

    Graphical View of Domain Structure for InterPro Entry P18564

    ProtoNet protein and cluster: P18564

    3 Blocks protein families:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB6_HUMAN, P18564
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB6_HUMAN, P18564
    Function: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its
    ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion

         Genatlas biochemistry entry for ITGB6:
    integrin,beta 6,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005102receptor binding ----
    GO:0005178integrin binding IEA--
         
    ITGB6 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itgb6):
     hematopoietic system  homeostasis/metabolism  immune system  integument  respiratory system 

    ITGB6 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Itgb6tm1Des for ITGB6
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGB6 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    Integrin Pathway1.00
    UPA-UPAR Pathway0.51
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    2Rho Family GTPases
    Rho Family GTPases1.00
    MAPK Signaling0.51
    ERK Signaling0.61
    ILK Signaling0.45
    Molecular Mechanisms of Cancer0.51
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.52
    Rac1 Pathway0.58
    Rap1 Pathway0.42
    Glioma Invasiveness0.54
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex1.00
    RhoA Pathway0.35
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.34
    5Focal Adhesion
    Focal Adhesion1.00
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.66
    HGF Pathway0.24

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB6 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 BioSystems Pathways for ITGB6 
        TGF Beta Signaling Pathway
    Integrin-mediated cell adhesion
    Focal Adhesion
    Arrhythmogenic right ventricular cardiomyopathy

    5        Reactome Pathways for ITGB6
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Integrin cell surface interactions
    Elastic fibre formation
    Signal Transduction


    5/6         Kegg Pathways  (Kegg details for ITGB6) (see all 6):
        Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton
    Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)


    ITGB6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGB6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for ITGB6 (P185643 ENSP000002832494) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=3 STRING: ENSP00000261023
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    FLNBO753693, ENSP000002959564I2D: score=1 STRING: ENSP00000295956
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    VTNP040043, ENSP000002262184I2D: score=1 STRING: ENSP00000226218
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion TAS2365683
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007275multicellular organismal development IEA--

    ITGB6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGB6
    Search CenterWatch for drugs/clinical trials and news about ITGB6 / ITB6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGB6 gene: 
    NM_000888.3  

    Unigene Cluster for ITGB6:

    Integrin, beta 6
    Hs.470399  [show with all ESTs]
    Unigene Representative Sequence: AL831998
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283249(uc002ubh.2 uc010fou.2 uc010fov.1) ENST00000409583
    ENST00000475438 ENST00000428609(uc010zcq.1) ENST00000409967 ENST00000409872
    ENST00000485635(uc010fow.1) ENST00000498478 ENST00000459712 ENST00000477514


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    Additional cDNA sequence: 

    AK026736.1 AK290300.1 AK304203.1 AK308325.1 AK313944.1 AL359053.1 AL831998.1 BC121178.2 
    BC143656.1 M35198.3 

    7 DOTS entries:

    DT.304563  DT.211681  DT.101981864  DT.101981865  DT.100017438  DT.100798893  DT.97806336 

    24/122 AceView cDNA sequences (see all 122):

    AI766295 BM976000 AI688355 AI627507 AI432955 AA993792 CA488829 AA449458 
    AW517786 M35198 AI865886 AI951468 AI140066 AW131358 AI685212 AI913015 
    AI934331 BX646691 CK819957 AA365835 AI570068 AA486731 AI273985 NM_000888 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB6    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                    -                                                                                                   
    SP2:                                                                                                                        
    SP3:                                                                    -     -                                             
    SP4:        -     -     -                                                                                                   
    SP5:                                                                                                        -               


    ECgene alternative splicing isoforms for ITGB6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAATTTAAA
    ITGB6 Expression
    About this image
    See ITGB6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGB6

    SOURCE GeneReport for Unigene cluster: Hs.470399
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGB6: 

              Fibrosis in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGB6 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ITGB61 integrin, beta 6 73.19(n)
    74.97(a)
      424191  XM_422037.3  XP_422037.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB66
    --
    --
    69(a)
    52(a)
    1 ↔ 1
    possible ortholog
    GL343371.1(672618-722765)
    AAWZ02040349(988-1653)
    zebrafish
    (Danio rerio)
    Actinopterygii itgb61 integrin, beta 6 60.93(n)
    59.31(a)
      100499533  XM_003199426.1  XP_003199474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mys3 central nervous system development
    calcium-dependent more
    35(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea pat-33 beta integrin 37(a)   III(3981133-3985933)   --


    ENSEMBL Gene Tree for ITGB6 (if available)
    TreeFam Gene Tree for ITGB6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGB6 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB22  ITGB72  ITGB32  ITGBL12  ITGB82  
    ITGB52  
    7 SIMAP similar genes for ITGB6 using alignment to 4 protein entries:     ITB6_HUMAN (see all proteins):
    ITGB3    ITGB8    ITGB5    ITGB7    ITGB4    ITGB2
    ITGB1

    ITGB6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGB6
    PGOHUM00000236423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1720 NCBI SNPs in ITGB6 are shown (see all 1720    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44702951,2
    C,F,A,H--160957824(+) TCCTAG/CAAGTT 1 -- ds50019Minor allele frequency- C:0.37NS WA CSA NA EA 485
    rs1866209981,2
    --160957830(+) AAGTTC/TAGAAT 1 -- ds50010--------
    rs45225561,2
    C,F,A,H--160957846(+) GGCAAA/GTATAG 1 -- ds5001 ese321Minor allele frequency- G:0.43NS EA WA NA CSA 2341
    rs1912274231,2
    --160957872(+) ATATGG/TGCTTT 1 -- ds50010--------
    rs1439477501,2
    --160957878(+) GCTTTA/GTGACT 1 -- ds50010--------
    rs1164988691,2
    F--160957889(+) TTGCCG/AAGACA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1838394261,2
    --160957949(+) ACATTC/TTTCAA 1 -- ds50010--------
    rs1391028151,2
    --160957989(+) ATGATC/TTTTTG 1 -- ds50010--------
    rs1439675611,2
    --160958013(+) ACAGAA/GTTAGT 1 -- ds50010--------
    rs75867511,2
    C,F,H--160958145(+) TATTAT/CCTTAA 1 -- ds500110Minor allele frequency- C:0.07NS EA NA WA 642

    HapMap Linkage Disequilibrium report for ITGB6 (160956177 - 161128399 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ITGB6: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ITGB6 for disorders           About GeneDecksing

    OMIM gene information: 147558    OMIM disorders: --

    20/21 diseases for ITGB6 (see all 21):    About MalaCards
    bullous keratopathy    mouth disease    keratopathy    oral squamous cell carcinoma
    squamous cell carcinoma    cytomegalovirus infection    pulmonary emphysema    emphysema
    cholestasis    hepatitis b    oral cancer    colon cancer
    carcinoma    breast carcinoma    nephropathy    hepatitis
    fibrosis    hypoxia    pancreatitis    prostatitis

    2 Novoseek disease relationships for ITGB6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 21.6 1 12009335 (1)
    tumors 0 1 7673344 (1)

    Human Genome Epidemiology (HuGE) Navigator: ITGB6 (9 documents)

    Export disorders for ITGB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGB6 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with ITGB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits. (PubMed id 1729173)1, 3, 9 Krissansen G.W....Watson J.D. (1992)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. (PubMed id 15194773)1, 2 Williams C.H....Stanway G. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits. (PubMed id 11807098)1, 2 van Der Flier A.... Sonnenberg A. (2002)
    6. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. (PubMed id 8120056)1, 3 Weinacker A....Sheppard D. (1994)
    7. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PubMed id 1382574)1, 2 Jiang W.-M....Krissansen G.W. (1992)
    8. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. (PubMed id 2365683)1, 2 Sheppard D.... Pytela R. (1990)
    9. Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6. (PubMed id 17438134)1, 9 Azare J....Bromberg J. (2007)
    10. A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. (PubMed id 7626292)1, 9 Huang X.Z....Sheppard D. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3694 HGNC: 6161 AceView: ITGB6 Ensembl:ENSG00000115221 euGenes: HUgn3694
    ECgene: ITGB6 Kegg: 3694 H-InvDB: ITGB6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGB6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGB6 gene:
    Search GeneIP for patents involving ITGB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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