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Aliases for ITGB6 Gene

Aliases for ITGB6 Gene

  • Integrin, Beta 6 2 3
  • Integrin Beta-6 3
  • AI1H 3

External Ids for ITGB6 Gene

Previous GeneCards Identifiers for ITGB6 Gene

  • GC02M158889
  • GC02M159484
  • GC02M160920
  • GC02M161158
  • GC02M160781
  • GC02M160664
  • GC02M152841

Summaries for ITGB6 Gene

Entrez Gene Summary for ITGB6 Gene

  • This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ITGB6 Gene

ITGB6 (Integrin, Beta 6) is a Protein Coding gene. Diseases associated with ITGB6 include amelogenesis imperfecta, type ih and hypocalcified amelogenesis imperfecta. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include integrin binding and virus receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB6 Gene

  • Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

Gene Wiki entry for ITGB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB6 Gene

Genomics for ITGB6 Gene

Regulatory Elements for ITGB6 Gene

Genomic Location for ITGB6 Gene

Start:
160,099,666 bp from pter
End:
160,271,888 bp from pter
Size:
172,223 bases
Orientation:
Minus strand

Genomic View for ITGB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB6 Gene

Proteins for ITGB6 Gene

  • Protein details for ITGB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18564-ITB6_HUMAN
    Recommended name:
    Integrin beta-6
    Protein Accession:
    P18564
    Secondary Accessions:
    • B2R9W5
    • C9JA97
    • Q0VA95
    • Q16500
    • Q53RG5
    • Q53RR6

    Protein attributes for ITGB6 Gene

    Size:
    788 amino acids
    Molecular mass:
    85936 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.

    Three dimensional structures from OCA and Proteopedia for ITGB6 Gene

    Alternative splice isoforms for ITGB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB6 Gene

Proteomics data for ITGB6 Gene at MOPED

Post-translational modifications for ITGB6 Gene

  • Glycosylation at Asn48, Asn97, Asn260, Asn387, Asn396, Asn463, Asn471, Asn541, and Asn575
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ITGB6 (Integrin beta 6)

No data available for DME Specific Peptides for ITGB6 Gene

Domains for ITGB6 Gene

Gene Families for ITGB6 Gene

HGNC:
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGB6 Gene

Graphical View of Domain Structure for InterPro Entry

P18564

UniProtKB/Swiss-Prot:

ITB6_HUMAN :
  • P18564
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB6: view

Function for ITGB6 Gene

Molecular function for ITGB6 Gene

GENATLAS Biochemistry: integrin,beta 6,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
UniProtKB/Swiss-Prot Function: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

Gene Ontology (GO) - Molecular Function for ITGB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity --
GO:0005178 integrin binding IEA --
genes like me logo Genes that share ontologies with ITGB6: view
genes like me logo Genes that share phenotypes with ITGB6: view

Animal Models for ITGB6 Gene

MGI Knock Outs for ITGB6:

Animal Model Products

miRNA for ITGB6 Gene

miRTarBase miRNAs that target ITGB6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGB6 Gene

Localization for ITGB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB6 Gene COMPARTMENTS Subcellular localization image for ITGB6 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with ITGB6: view

Pathways for ITGB6 Gene

genes like me logo Genes that share pathways with ITGB6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITGB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion TAS 2365683
GO:0007160 cell-matrix adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ITGB6: view

Transcripts for ITGB6 Gene

Unigene Clusters for ITGB6 Gene

Integrin, beta 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITGB6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for ITGB6 Gene

GeneLoc Exon Structure for
ITGB6
ECgene alternative splicing isoforms for
ITGB6

Expression for ITGB6 Gene

mRNA expression in normal human tissues for ITGB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB6 Gene

This gene is overexpressed in Kidney - Cortex (8.9), Lung (6.2), Muscle - Skeletal (5.6), Esophagus - Mucosa (5.3), and Bladder (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGB6 Gene

SOURCE GeneReport for Unigene cluster for ITGB6 Gene Hs.470399

genes like me logo Genes that share expressions with ITGB6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ITGB6 Gene

Orthologs for ITGB6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB6 35
  • 99.37 (n)
  • 99.49 (a)
ITGB6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGB6 35
  • 89.79 (n)
  • 93.52 (a)
ITGB6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB6 35
  • 92.55 (n)
  • 95.68 (a)
ITGB6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb6 35
  • 86.13 (n)
  • 90.71 (a)
Itgb6 16
Itgb6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGB6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB6 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb6 35
  • 87.11 (n)
  • 90.97 (a)
chicken
(Gallus gallus)
Aves ITGB6 35
  • 73.23 (n)
  • 74.97 (a)
ITGB6 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB6 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itgb6 35
  • 67.1 (n)
  • 67.34 (a)
zebrafish
(Danio rerio)
Actinopterygii itgb6 35
  • 61 (n)
  • 59.48 (a)
itgb6 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bgrInt-ngr 37
  • 31 (a)
mys 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 37
  • 37 (a)
Species with no ortholog for ITGB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB6 Gene

ENSEMBL:
Gene Tree for ITGB6 (if available)
TreeFam:
Gene Tree for ITGB6 (if available)

Paralogs for ITGB6 Gene

Selected SIMAP similar genes for ITGB6 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ITGB6 Gene

genes like me logo Genes that share paralogs with ITGB6: view

Variants for ITGB6 Gene

Sequence variations from dbSNP and Humsavar for ITGB6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs585868 -- 160,154,304(+) tgcaa(A/C)ccatt intron-variant
rs897832 -- 160,124,521(+) ACATC(A/G)TCCAA intron-variant
rs983916 -- 160,158,555(-) ACTTG(A/C)ATTAG intron-variant
rs996112 -- 160,141,011(-) TAAAA(C/T)GACGT intron-variant
rs1037694 -- 160,172,481(+) CCAAG(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB6 Gene

Variant ID Type Subtype PubMed ID
nsv875346 CNV Gain 21882294
esv2721038 CNV Deletion 23290073
nsv528083 CNV Loss 19592680

Relevant External Links for ITGB6 Gene

HapMap Linkage Disequilibrium report
ITGB6
Human Gene Mutation Database (HGMD)
ITGB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB6 Gene

Disorders for ITGB6 Gene

(2) Novoseek inferred disease relationships for ITGB6 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 21.6 1
tumors 0 1

Relevant External Links for ITGB6

Genetic Association Database (GAD)
ITGB6
Human Genome Epidemiology (HuGE) Navigator
ITGB6
genes like me logo Genes that share disorders with ITGB6: view

No data available for UniProtKB/Swiss-Prot for ITGB6 Gene

Publications for ITGB6 Gene

  1. Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits. (PMID: 1729173) Krissansen G.W. … Watson J.D. (Immunogenetics 1992) 2 3 23
  2. A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. (PMID: 7626292) Huang X.Z. … Sheppard D. (Am. J. Respir. Cell Mol. Biol. 1995) 3 23
  3. Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6. (PMID: 17438134) Azare J. … Bromberg J. (Mol. Cell. Biol. 2007) 3 23
  4. Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31. (PMID: 7959743) FernA!ndez-Ruiz E. … SA!nchez-Madrid F. (Genomics 1994) 3 23
  5. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. (PMID: 8120056) Weinacker A. … Sheppard D. (J. Biol. Chem. 1994) 2 3

Products for ITGB6 Gene

  • Addgene plasmids for ITGB6

Sources for ITGB6 Gene

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