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Aliases for ITGB5 Gene

Aliases for ITGB5 Gene

  • Integrin Subunit Beta 5 2 3 5
  • Integrin, Beta 5 2

External Ids for ITGB5 Gene

Previous GeneCards Identifiers for ITGB5 Gene

  • GC03M121191
  • GC03M124498
  • GC03M125763
  • GC03M125802
  • GC03M125964
  • GC03M121856
  • GC03M124480

Summaries for ITGB5 Gene

GeneCards Summary for ITGB5 Gene

ITGB5 (Integrin Subunit Beta 5) is a Protein Coding gene. Diseases associated with ITGB5 include Villous Adenocarcinoma and Localized Scleroderma. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB5 Gene

  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

  • (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Gene Wiki entry for ITGB5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB5 Gene

Genomics for ITGB5 Gene

Regulatory Elements for ITGB5 Gene

Enhancers for ITGB5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITGB5 on UCSC Golden Path with GeneCards custom track

Promoters for ITGB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGB5 Gene

Chromosome:
3
Start:
124,761,948 bp from pter
End:
124,901,418 bp from pter
Size:
139,471 bases
Orientation:
Minus strand

Genomic View for ITGB5 Gene

Genes around ITGB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB5 Gene

Proteins for ITGB5 Gene

  • Protein details for ITGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18084-ITB5_HUMAN
    Recommended name:
    Integrin beta-5
    Protein Accession:
    P18084
    Secondary Accessions:
    • B0LPF8
    • B2RD70

    Protein attributes for ITGB5 Gene

    Size:
    799 amino acids
    Molecular mass:
    88054 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with NOV (PubMed:15611078).
    • (Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.

neXtProt entry for ITGB5 Gene

Proteomics data for ITGB5 Gene at MOPED

Post-translational modifications for ITGB5 Gene

  • Glycosylation at Thr 199, Asn 347, Asn 460, Asn 477, Asn 505, Asn 552, Asn 586, Asn 654, and Asn 705
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ITGB5 (Integrin beta 5)
  • Cell Signaling Technology (CST) Antibodies for ITGB5 (ITGB5)

No data available for DME Specific Peptides for ITGB5 Gene

Domains & Families for ITGB5 Gene

Gene Families for ITGB5 Gene

Suggested Antigen Peptide Sequences for ITGB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18084

UniProtKB/Swiss-Prot:

ITB5_HUMAN :
  • Contains 1 PSI domain.
  • Belongs to the integrin beta chain family.
Domain:
  • Contains 1 PSI domain.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB5: view

Function for ITGB5 Gene

Molecular function for ITGB5 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
genes like me logo Genes that share phenotypes with ITGB5: view

Animal Models for ITGB5 Gene

MGI Knock Outs for ITGB5:

Animal Model Products

miRNA for ITGB5 Gene

miRTarBase miRNAs that target ITGB5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB5 Gene

Localization for ITGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB5 Gene COMPARTMENTS Subcellular localization image for ITGB5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008305 integrin complex IEA --
GO:0045335 phagocytic vesicle TAS --
genes like me logo Genes that share ontologies with ITGB5: view

Pathways & Interactions for ITGB5 Gene

genes like me logo Genes that share pathways with ITGB5: view

SIGNOR curated interactions for ITGB5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 24036928
GO:0035987 endodermal cell differentiation IEP 23154389
genes like me logo Genes that share ontologies with ITGB5: view

Drugs & Compounds for ITGB5 Gene

(4) Drugs for ITGB5 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilengitide Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins 0
CNTO-95 Pharma 0
GLPG0187 Pharma 0
genes like me logo Genes that share compounds with ITGB5: view

Transcripts for ITGB5 Gene

Unigene Clusters for ITGB5 Gene

Integrin, beta 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ITGB5 Gene

GeneLoc Exon Structure for
ITGB5
ECgene alternative splicing isoforms for
ITGB5

Expression for ITGB5 Gene

mRNA expression in normal human tissues for ITGB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB5 Gene

This gene is overexpressed in Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for ITGB5 Gene

This gene is overexpressed in Liver (16.8) and Monocytes (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGB5 Gene



SOURCE GeneReport for Unigene cluster for ITGB5 Gene Hs.536663

genes like me logo Genes that share expression patterns with ITGB5: view

Protein tissue co-expression partners for ITGB5 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ITGB5 Gene

Orthologs for ITGB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGB5 35
  • 89.45 (n)
  • 91.99 (a)
ITGB5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB5 35
  • 87.44 (n)
  • 89.74 (a)
ITGB5 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb5 35
  • 86.82 (n)
  • 91.74 (a)
Itgb5 16
Itgb5 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGB5 35
  • 99.29 (n)
  • 99.25 (a)
ITGB5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb5 35
  • 86.82 (n)
  • 91.99 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGB5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB5 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGB5 35
  • 74.58 (n)
  • 77.03 (a)
ITGB5 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB5 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216279 35
  • 68.14 (n)
  • 68.73 (a)
zebrafish
(Danio rerio)
Actinopterygii itgb5 35
  • 67.79 (n)
  • 72.48 (a)
wufi30h12 35
itgb5 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bgrInt-ngr 37
  • 32 (a)
mys 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 37
  • 38 (a)
Species with no ortholog for ITGB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB5 Gene

ENSEMBL:
Gene Tree for ITGB5 (if available)
TreeFam:
Gene Tree for ITGB5 (if available)

Paralogs for ITGB5 Gene

genes like me logo Genes that share paralogs with ITGB5: view

Variants for ITGB5 Gene

Sequence variations from dbSNP and Humsavar for ITGB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2291090 - 124,796,799(+) CTCCA(A/C/G)TGATA reference, missense
rs2291089 - 124,796,789(+) AGCTT(C/T)GGGCC reference, missense
rs2291087 - 124,796,651(+) TCCCG(C/T)TGCAC reference, missense
rs2674 -- 124,763,375(-) TTGGC(A/G)CTCTC utr-variant-3-prime
rs2675 -- 124,763,266(-) CAAGA(A/C)GACTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ITGB5 Gene

Variant ID Type Subtype PubMed ID
nsv877402 CNV Gain 21882294
nsv877403 CNV Loss 21882294
nsv3981 CNV Insertion 18451855
esv2725850 CNV Deletion 23290073
esv2725852 CNV Deletion 23290073
esv22852 CNV Gain+Loss 19812545
nsv820971 CNV Deletion 20802225
esv2454361 CNV Deletion 19546169
esv9373 CNV Loss 19470904
esv2607536 CNV Insertion 19546169
esv271937 CNV Insertion 20981092
nsv877404 CNV Loss 21882294
esv23075 CNV Loss 19812545

Variation tolerance for ITGB5 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGB5 Gene

Human Gene Mutation Database (HGMD)
ITGB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB5 Gene

Disorders for ITGB5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITGB5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
villous adenocarcinoma
localized scleroderma
  • circumscribed scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search ITGB5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGB5

Genetic Association Database (GAD)
ITGB5
Human Genome Epidemiology (HuGE) Navigator
ITGB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGB5
genes like me logo Genes that share disorders with ITGB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB5 Gene

Publications for ITGB5 Gene

  1. cDNA sequence of the human integrin beta 5 subunit. (PMID: 2211615) McLean J.W. … Bodary S.C. (J. Biol. Chem. 1990) 2 3 4 67
  2. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PMID: 18550570) Brendle A. … FAPrsti A. (Carcinogenesis 2008) 3 23
  3. Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V. (PMID: 12769841) CardA^-Vila M. … Pasqualini R. (Mol. Cell 2003) 3 23
  4. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PMID: 12356872) Zhang H. … Stromblad S. (J. Cell Biol. 2002) 3 23
  5. A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. (PMID: 7689573) Pasqualini R. … Hemler M.E. (J. Cell. Sci. 1993) 3 23

Products for ITGB5 Gene

Sources for ITGB5 Gene

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