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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGB5 Gene

protein-coding   GIFtS: 66
GCID: GC03M124498

Integrin, Beta 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Beta 51 2
Integrin Beta-52

External Ids:    HGNC: 61601   Entrez Gene: 36932   Ensembl: ENSG000000827817   OMIM: 1475615   UniProtKB: P180843   

Export aliases for ITGB5 gene to outside databases

Previous GC identifers: GC03M121191 GC03M125763 GC03M125802 GC03M125964 GC03M121856


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ITGB5 Gene: 
ITGB5 (integrin, beta 5) is a protein-coding gene. Diseases associated with ITGB5 include localized scleroderma, and scleroderma, and among its related super-pathways are Integrin-mediated cell adhesion and ECM-receptor interaction. GO annotations related to this gene include integrin binding and receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084
Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Wiki entry for ITGB5 (Integrin, beta 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGB5 gene promoter:
         ER-alpha   AML1a   Pbx1a   Nkx2-5   Cdc5   NRF-2   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

ITGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M124498:  view genomic region     (about GC identifiers)

Start:
124,480,795 bp from pter      End:
124,606,674 bp from pter
Size:
125,880 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084 (See protein sequence)
Recommended Name: Integrin beta-5 precursor  
Size: 799 amino acids; 88054 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10.
Interacts with DAB2
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B0LPF8 B2RD70

Explore the universe of human proteins at neXtProt for ITGB5: NX_P18084

Explore proteomics data for ITGB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18084

  • ITGB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGB5 Protein Expression
    REFSEQ proteins: NP_002204.2  
    ENSEMBL proteins: 
     ENSP00000296181   ENSP00000420814   ENSP00000418367   ENSP00000418079   ENSP00000419198  
    Reactome Protein details: P18084
    Human Recombinant Protein Products for ITGB5: 
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    Novus Biologicals ITGB5 Proteins
    Novus Biologicals ITGB5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IEA--
    GO:0016020membrane ----
    GO:0031252cell leading edge IEA--

    ITGB5 for ontologies           About GeneDecksing



    ITGB5 Antibody Products: 
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    Assay Products for ITGB5: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ITG: Integrins

    5/9 InterPro protein domains (see all 9):
     IPR002369 Integrin_bsu_N
     IPR000742 EG-like_dom
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P18084

    ProtoNet protein and cluster: P18084

    3 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 VWFA domain


    ITGB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB5_HUMAN, P18084
    Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI1694173
         
    ITGB5 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for ITGB5:
     Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb5):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  normal  other  tumorigenesis 
     vision/eye 

    ITGB5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itgb5tm1Des for ITGB5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGB5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGB5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGB5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGB5 

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    SwitchGear 3'UTR luciferase reporter plasmidITGB5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGB5 About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    Syndecan interactions0.44
    Integrin cell surface interactions0.32
    ECM-receptor interaction0.42
    3Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ITGB5
        Metalloproteases in connective tissue degradation
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB5 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 Cell Signaling Technology (CST) Pathways for ITGB5
        Angiogenesis
    Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ITGB5
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5 BioSystems Pathways for ITGB5
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by focal adhesion kinase


    5/15        Reactome Pathways for ITGB5 (see all 15)
        Cross-presentation of particulate exogenous antigens (phagosomes)
    Integrin cell surface interactions
    Smooth Muscle Contraction
    Antigen processing-Cross presentation
    Elastic fibre formation

    1 PharmGKB Pathway for ITGB5
        VEGF Signaling Pathway

    5/9         Kegg Pathways  (Kegg details for ITGB5) (see all 9):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton


    ITGB5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for ITGB5 (P180841, 2, 3 ENSP000002961814) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8Q129292, 3, ENSP000002811724MINT-45899 I2D: score=3 STRING: ENSP00000281172
    TENC1Q63HR22, 3, ENSP000003197564MINT-61566 I2D: score=2 STRING: ENSP00000319756
    PDIA3P301012, 3MINT-4301466 I2D: score=1 
    MYO10Q9HD672, 3, ENSP000003911064MINT-8199775 MINT-8199748 I2D: score=3 STRING: ENSP00000391106
    ITGAVP067561, 3, ENSP000002610234EBI-1223434,EBI-298282 I2D: score=4 STRING: ENSP00000261023
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006936muscle contraction TAS--
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGB5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGB5 (ITB5)

    1 Novoseek inferred chemical compound relationship for ITGB5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 15.5 3 7515874 (2)

    Search CenterWatch for drugs/clinical trials and news about ITGB5 / ITB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGB5 gene: 
    NM_002213.3  

    Unigene Cluster for ITGB5:

    Integrin, beta 5
    Hs.536663  [show with all ESTs]
    Unigene Representative Sequence: AK091595
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296181(uc010hrx.3 uc003eho.3) ENST00000460797 ENST00000461306
    ENST00000481591 ENST00000572186(uc003ehp.1) ENST00000488466 ENST00000474838
    ENST00000496703 ENST00000476988 ENST00000465464 ENST00000483168
    miRNA
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    Additional mRNA sequence: 

    AK054968.1 AK091595.1 AK130168.1 AK309551.1 AK315429.1 BC006541.2 J05633.1 M35011.1 
    X53002.1 

    24 DOTS entries:

    DT.441725  DT.452865  DT.92448283  DT.102833259  DT.100877190  DT.95275215  DT.100877185  DT.87002074 
    DT.100877179  DT.100877186  DT.102833258  DT.120860496  DT.120860508  DT.99938241  DT.120860544  DT.92448288 
    DT.100030466  DT.100690117  DT.120860477  DT.120860533  DT.120860549  DT.86995704  DT.40116835  DT.91679976 

    24/487 AceView cDNA sequences (see all 487):

    BG746469 AI360666 CD558839 BQ671257 BF436004 BM547921 BQ673891 BQ710245 
    CF131340 AA434397 BG760934 CB151690 T29697 BM993726 BQ278978 AI472244 
    AW015421 CA406325 BX396260 BX482120 AI247496 AA345203 CA454186 M35011 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
    SP1:                                      -                 -                                                                 -     -                           
    SP2:              -     -     -     -     -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -                 -                 -                                                                                                   
    SP5:                                      -                                                                                                                     

    ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
    SP1:        -           -                                 
    SP2:                                                      
    SP3:                    -                                 
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ITGB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGB5 expression in normal human tissues (normalized intensities)      ITGB5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCTGCG
    ITGB5 Expression
    About this image


    ITGB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 2 entries
             Zygote Zygote
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Muscoskeletal System)
             Mandibular Condyle

    See ITGB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGB5

    SOURCE GeneReport for Unigene cluster: Hs.536663
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGB5: 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGB5 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb51 , 5 integrin beta 51, 5 86.82(n)1
    91.74(a)1
      16 (24.22 cM)5
    164191  NM_001145884.11  NP_001139356.11 
     338296655 
    chicken
    (Gallus gallus)
    Aves ITGB51 integrin, beta 5 73.91(n)
    76.13(a)
      395142  NM_204483.1  NP_989814.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB56
    integrin, beta 5
    73(a)
    1 ↔ 1
    1(78142882-78227422)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi30h122 wufi30h12 77.16(n)   334090  BI884761.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mys3 central nervous system development
    calcium-dependent more
    40(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea pat-33 beta integrin 38(a)   III(3981133-3985933)   --


    ENSEMBL Gene Tree for ITGB5 (if available)
    TreeFam Gene Tree for ITGB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGB5 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB72  ITGB22  ITGBL12  ITGB32  ITGB82  
    ITGB62  
    7 SIMAP similar genes for ITGB5 using alignment to 7 protein entries:     ITB5_HUMAN (see all proteins):
    ITGB3    ITGB1    ITGB6    ITGB8    ITGB7    ITGB2
    ITGB4

    ITGB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2721 SNPs in ITGB5 are shown (see all 2721)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8490191,2
    C,F,O,H--124481461(-) CTTAAA/TCATCA 1 -- int128Minor allele frequency- T:0.37MN NA NS EA WA CSA 1813
    rs729707131,2
    C,F--124481477(+) ACTTCG/CTGTGG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1116695791,2
    C--124481480(+) TCGTGG/TGGGAA 1 -- int10--------
    rs1418735501,2
    --124481503(+) CCTTGC/TTTGTC 1 -- int10--------
    rs1161822791,2
    C,F--124481506(+) TGCTTG/ATCTGT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1995691151,2
    --124481541(+) TCAGA-/ACAAG 
    GGAGGGAG
    ACAAG
    1 -- int10--------
    rs801235361,2
    C--124481542(+) TCAGAA/CCAAGG 1 -- int10--------
    rs1120202821,2
    C--124481542(+) CAGAACAAGGGAG
    GGAGAC
    /-
    CAAGG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs711454871,2
    C--124481548(-) ACCACCCCTTGGT
    CTCCCT
    /-
    CCCTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1384381691,2
    C--124481609(+) AAAGG-/TATC  
            
    TATCT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGB5 (124480795 - 124606674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ITGB5 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725850CNV Deletion23290073
    esv2454361CNV Deletion19546169
    esv2725852CNV Deletion23290073
    nsv820971CNV Deletion20802225
    esv2607536CNV Insertion19546169
    esv271937CNV Insertion20981092
    nsv3981CNV Insertion18451855
    esv23075CNV Loss19812545
    nsv877404CNV Loss21882294
    nsv877403CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147561    OMIM disorders: --

    20/27 diseases for ITGB5 (see all 27):    About MalaCards
    localized scleroderma    scleroderma    cavernous malformation    merkel cell carcinoma
    synovitis    chondrosarcoma    hypertrophic cardiomyopathy    kaposi's sarcoma
    malignant glioma    dilated cardiomyopathy    osteosarcoma    sarcoma
    obesity    cerebritis    hepatitis b    rheumatoid arthritis
    breast cancer    ovarian cancer    squamous cell carcinoma    endotheliitis


    ITGB5 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ITGB5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 4.44 1 7551009 (1)
    breast cancer 1.52 1 18550570 (1)
    tumors 0 2 7551009 (1), 11746774 (1)

    Genetic Association Database (GAD): ITGB5
    Human Genome Epidemiology (HuGE) Navigator: ITGB5 (6 documents)

    Export disorders for ITGB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGB5 gene, integrated from 9 sources (see all 123):
    (articles sorted by number of sources associating them with ITGB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence of the human integrin beta 5 subunit. (PubMed id 2211615)1, 2, 3 McLean J.W.... Bodary S.C. (1990)
    2. Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)1, 4, 9 Brendle A....Forsti A. (2008)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Role of genetic susceptibility to latent adenoviral i nfection and decreased lung function. (PubMed id 19502044)1, 4 Kasuga I....Sandford A.J. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Myosin-X provides a motor-based link between integrins and the cytoskeleton. (PubMed id 15156152)1, 2 Zhang H....Stromblad S. (2004)
    8. Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. (PubMed id 2371275)1, 2 Suzuki S.... Tanihara H. (1990)
    9. Cloning, primary structure and properties of a novel human integrin beta subunit. (PubMed id 2328726)1, 2 Ramaswamy H. and Hemler M.E. (1990)
    10. A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. (PubMed id 7689573)1, 9 Pasqualini R....Hemler M.E. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3693 HGNC: 6160 AceView: ITGB5 Ensembl:ENSG00000082781 euGenes: HUgn3693
    ECgene: ITGB5 Kegg: 3693 H-InvDB: ITGB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGB5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGB5 gene:
    Search GeneIP for patents involving ITGB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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