External Ids for ITGB5 Gene
Previous GeneCards Identifiers for ITGB5 Gene
This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
GeneCards Summary for ITGB5 Gene
ITGB5 (Integrin Subunit Beta 5) is a Protein Coding gene. Diseases associated with ITGB5 include Villous Adenocarcinoma and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and ECM proteoglycans. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ITGB3.
UniProtKB/Swiss-Prot for ITGB5 Gene
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.