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Aliases for ITGB5 Gene

Aliases for ITGB5 Gene

  • Integrin, Beta 5 2 3

External Ids for ITGB5 Gene

Previous GeneCards Identifiers for ITGB5 Gene

  • GC03M121191
  • GC03M124498
  • GC03M125763
  • GC03M125802
  • GC03M125964
  • GC03M121856
  • GC03M124480

Summaries for ITGB5 Gene

GeneCards Summary for ITGB5 Gene

ITGB5 (Integrin, Beta 5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB5 Gene

  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Wiki entry for ITGB5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB5 Gene

Genomics for ITGB5 Gene

Regulatory Elements for ITGB5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGB5 Gene

Start:
124,761,948 bp from pter
End:
124,901,418 bp from pter
Size:
139,471 bases
Orientation:
Minus strand

Genomic View for ITGB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB5 Gene

Proteins for ITGB5 Gene

  • Protein details for ITGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18084-ITB5_HUMAN
    Recommended name:
    Integrin beta-5
    Protein Accession:
    P18084
    Secondary Accessions:
    • B0LPF8
    • B2RD70

    Protein attributes for ITGB5 Gene

    Size:
    799 amino acids
    Molecular mass:
    88054 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity).

neXtProt entry for ITGB5 Gene

Proteomics data for ITGB5 Gene at MOPED

Post-translational modifications for ITGB5 Gene

  • Glycosylation at Thr199, Asn347, Asn460, Asn477, Asn505, Asn552, Asn586, Asn654, and Asn705
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGB5 Gene

Antibody Products

  • R&D Systems Antibodies for ITGB5 (Integrin beta 5)
  • Cell Signaling Technology (CST) Antibodies for ITGB5 (ITGB5)

No data available for DME Specific Peptides for ITGB5 Gene

Domains for ITGB5 Gene

Gene Families for ITGB5 Gene

HGNC:
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18084

UniProtKB/Swiss-Prot:

ITB5_HUMAN :
  • P18084
Domain:
  • Contains 1 PSI domain.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB5: view

Function for ITGB5 Gene

Molecular function for ITGB5 Gene

UniProtKB/Swiss-Prot Function: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Ontology (GO) - Molecular Function for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 1694173
genes like me logo Genes that share ontologies with ITGB5: view
genes like me logo Genes that share phenotypes with ITGB5: view

Animal Models for ITGB5 Gene

MGI Knock Outs for ITGB5:

Animal Model Products

miRNA for ITGB5 Gene

miRTarBase miRNAs that target ITGB5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB5

Clone Products

  • Addgene plasmids for ITGB5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGB5 Gene

Localization for ITGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB5 Gene COMPARTMENTS Subcellular localization image for ITGB5 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex --
GO:0009986 cell surface IDA 23154389
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ITGB5: view

Pathways for ITGB5 Gene

genes like me logo Genes that share pathways with ITGB5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion --
GO:0007160 cell-matrix adhesion IMP 24036928
genes like me logo Genes that share ontologies with ITGB5: view

Compounds for ITGB5 Gene

(1) Novoseek inferred chemical compound relationships for ITGB5 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 15.5 2
genes like me logo Genes that share compounds with ITGB5: view

Transcripts for ITGB5 Gene

Unigene Clusters for ITGB5 Gene

Integrin, beta 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGB5

Clone Products

  • Addgene plasmids for ITGB5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ITGB5 Gene

GeneLoc Exon Structure for
ITGB5
ECgene alternative splicing isoforms for
ITGB5

Expression for ITGB5 Gene

mRNA expression in normal human tissues for ITGB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB5 Gene

This gene is overexpressed in Artery - Aorta (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGB5 Gene

SOURCE GeneReport for Unigene cluster for ITGB5 Gene Hs.536663

genes like me logo Genes that share expressions with ITGB5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ITGB5 Gene

Orthologs for ITGB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB5 35
  • 99.29 (n)
  • 99.25 (a)
ITGB5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGB5 35
  • 89.45 (n)
  • 91.99 (a)
ITGB5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB5 35
  • 87.44 (n)
  • 89.74 (a)
ITGB5 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb5 35
  • 86.82 (n)
  • 91.74 (a)
Itgb5 16
Itgb5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGB5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB5 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb5 35
  • 86.82 (n)
  • 91.99 (a)
chicken
(Gallus gallus)
Aves ITGB5 35
  • 74.58 (n)
  • 77.03 (a)
ITGB5 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB5 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216279 35
  • 68.14 (n)
  • 68.73 (a)
zebrafish
(Danio rerio)
Actinopterygii itgb5 35
  • 67.79 (n)
  • 72.48 (a)
itgb5 36
  • 68 (a)
OneToOne
wufi30h12 35
fruit fly
(Drosophila melanogaster)
Insecta bgrInt-ngr 37
  • 32 (a)
mys 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 37
  • 38 (a)
Species with no ortholog for ITGB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB5 Gene

ENSEMBL:
Gene Tree for ITGB5 (if available)
TreeFam:
Gene Tree for ITGB5 (if available)

Paralogs for ITGB5 Gene

genes like me logo Genes that share paralogs with ITGB5: view

Variants for ITGB5 Gene

Sequence variations from dbSNP and Humsavar for ITGB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2674 -- 124,763,375(-) TTGGC(A/G)CTCTC utr-variant-3-prime
rs2675 -- 124,763,266(-) CAAGA(A/C)GACTG utr-variant-3-prime
rs2676 -- 124,763,140(-) TTTTC(C/T)GCGTG utr-variant-3-prime
rs14386 -- 124,762,205(+) GTAAG(A/G)GGAAT utr-variant-3-prime
rs17469 -- 124,844,072(-) CAGTT(G/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB5 Gene

Variant ID Type Subtype PubMed ID
nsv877402 CNV Gain 21882294
nsv877403 CNV Loss 21882294
nsv3981 CNV Insertion 18451855
esv2725850 CNV Deletion 23290073
esv2725852 CNV Deletion 23290073
esv22852 CNV Gain+Loss 19812545
nsv820971 CNV Deletion 20802225
esv2454361 CNV Deletion 19546169
esv9373 CNV Loss 19470904
esv2607536 CNV Insertion 19546169
esv271937 CNV Insertion 20981092
nsv877404 CNV Loss 21882294
esv23075 CNV Loss 19812545

Relevant External Links for ITGB5 Gene

HapMap Linkage Disequilibrium report
ITGB5
Human Gene Mutation Database (HGMD)
ITGB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB5 Gene

Disorders for ITGB5 Gene

(3) Novoseek inferred disease relationships for ITGB5 Gene

Disease -log(P) Hits PubMed IDs
carcinoma 4.44 1
breast cancer 1.52 1
tumors 0 2

Relevant External Links for ITGB5

Genetic Association Database (GAD)
ITGB5
Human Genome Epidemiology (HuGE) Navigator
ITGB5
genes like me logo Genes that share disorders with ITGB5: view

No data available for UniProtKB/Swiss-Prot for ITGB5 Gene

Publications for ITGB5 Gene

  1. cDNA sequence of the human integrin beta 5 subunit. (PMID: 2211615) McLean J.W. … Bodary S.C. (J. Biol. Chem. 1990) 2 3 4
  2. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PMID: 18550570) Brendle A. … FAPrsti A. (Carcinogenesis 2008) 3 23 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Myosin-X provides a motor-based link between integrins and the cytoskeleton. (PMID: 15156152) Zhang H. … Stromblad S. (Nat. Cell Biol. 2004) 3 4
  5. Role of genetic susceptibility to latent adenoviral infection and decreased lung function. (PMID: 19502044) Kasuga I. … Sandford A.J. (Respir Med 2009) 3 48

Products for ITGB5 Gene

  • Addgene plasmids for ITGB5

Sources for ITGB5 Gene

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