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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGB5 Gene

protein-coding GIFtS: 64
GCID: GC03M124498

integrin, beta 5

Explore 21 diseases affiliated with
ITGB5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Beta 5¹ ²
Integrin Beta-5²

External Ids:	HGNC: 6160¹	Entrez Gene: 3693²	Ensembl: ENSG00000082781⁷	OMIM: 147561⁵	UniProtKB: P18084³

Export aliases for ITGB5 gene to outside databases

Previous GC identifers: GC03M121191 GC03M125763 GC03M125802 GC03M125964 GC03M121856

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084

Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Wiki entry for ITGB5 (Integrin, beta 5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGB5 gene promoter:
ER-alpha AML1a Pbx1a Nkx2-5 Cdc5 NRF-2 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGB5 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGB5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2 Ensembl cytogenetic band: 3q21.2 HGNC cytogenetic band: 3q21.2

ITGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB5 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M124498: view genomic region (about GC identifiers)

Start:	124,480,795 bp from pter	End:	124,606,674 bp from pter
Size:	125,880 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084 (See protein sequence)

Recommended Name: Integrin beta-5 precursor

Size: 799 amino acids; 88054 Da

Subunit: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Interacts

with DAB2

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B0LPF8 B2RD70

Explore the universe of human proteins at neXtProt for ITGB5: NX_P18084

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18084

ITGB5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002204.2

ENSEMBL proteins:

ENSP00000296181 ENSP00000420814 ENSP00000418367 ENSP00000418079 ENSP00000419198

Reactome Protein details: P18084
Human Recombinant Protein Products for ITGB5:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ITGB5 OriGene Custom Protein Services for ITGB5
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	Novus Biologicals ITGB5 Proteins Novus Biologicals ITGB5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005925	focal adhesion	IEA	--
GO:0008305	integrin complex	IEA	--
GO:0031252	cell leading edge	IEA	--
GO:0045335	phagocytic vesicle	TAS	--

ITGB5 for ontologies About GeneDecksing

ITGB5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB5
	R&D Systems Antibodies for ITGB5 (Integrin beta 5)
	Cell Signaling Technology (CST) Antibodies for ITGB5
	Browse OriGene Antibodies OriGene Custom Antibody Services for ITGB5
	GenScript Custom Superior Antibodies Services for ITGB5
	Novus Biologicals ITGB5 Antibodies
	Abcam antibodies for ITGB5
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ITGB5

Assay Products for ITGB5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for ITGB5 (Integrin beta 5)
	GenScript Custom Assay Services for ITGB5
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGB5 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR003659 Plexin-like

IPR002369 Integrin_bsu_N

IPR000742 EG-like_dom

IPR012896 Integrin_bsu_tail

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry P18084

ProtoNet protein and cluster: P18084

3 Blocks protein families:

IPB001169 Integrin beta

IPB002035 Von Willebrand factor type A domain signature

IPB002369 Integrin beta subunit signature

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084

Similarity: Belongs to the integrin beta chain family

Similarity: Contains 1 PSI domain

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ITB5_HUMAN, P18084

Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IPI	--

ITGB5 for ontologies About GeneDecksing

Phenotypes:
7 GenomeRNAi human phenotypes for ITGB5:

Decreased focal adhesion (FA)	Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella enterica
Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella-containin

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itgb5):

behavior/neurological	cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism
immune system	integument	normal	other	tumorigenesis
vision/eye

ITGB5 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Itgb5^tm1Des for ITGB5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGB5

miRNA Products:		OriGene 3'-UTR Clone: ITGB5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGB5:
		hsa-miR-659 hsa-miR-548k hsa-miR-421 hsa-miR-3162-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB5 (see all 7) OriGene shRNA RFP: ITGB5 OriGene siRNA: ITGB5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ITGB5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ITGB5
			Sirion Biotech Customized adenovirus for overexpression of ITGB5 Sirion Biotech Customized adenovirus for potent knockdown of ITGB5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGB5 (NM_002213)
		Sino Biological Human cDNA Clone for ITGB5
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGB5
		Search LifeMap BioReagents cell lines for ITGB5
		Sirion Biotech Customized stable knockdown cell line services for ITGB5 Sirion Biotech Customized inducible knockdown cell line services for ITGB5 Sirion Biotech Customized stable overexpressing cell line services for ITGB5 Sirion Biotech Customized inducible overexpressing cell line services for ITGB5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ITGB5

	Metalloproteases in connective tissue degradation
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB5 (see all 34)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

3 Cell Signaling Technology (CST) Pathways for ITGB5

	Angiogenesis
	Cytoskeletal Signaling
	Adhesion

1 GeneGo (Thomson Reuters) Pathway for ITGB5

Cell adhesion Endothelial cell contacts by non-junctional mechanisms

5 BioSystems Pathways for ITGB5

	Integrin-mediated cell adhesion
	Focal Adhesion
	Arrhythmogenic right ventricular cardiomyopathy
	Signaling events mediated by focal adhesion kinase
	Regulation of nuclear SMAD2/3 signaling

5/12 Reactome Pathways for ITGB5 (see all 12)

	Cross-presentation of particulate exogenous antigens (phagosomes)
	Integrin cell surface interactions
	Smooth Muscle Contraction
	Antigen processing-Cross presentation
	Elastic fibre formation

1 PharmGKB Pathway for ITGB5

VEGF Signaling Pathway

5/7 Kegg Pathways (Kegg details for ITGB5) (see all 7):

	Phagosome
	Focal adhesion
	ECM-receptor interaction
	Regulation of actin cytoskeleton
	Hypertrophic cardiomyopathy (HCM)

ITGB5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGB5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/159 Interacting proteins for ITGB5 (P18084^{1, 2, 3} ENSP00000296181⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 159)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPS8	Q12929²^,³, ENSP00000281172⁴	MINT-45899 I2D: score=3 STRING: ENSP00000281172
TENC1	Q63HR2²^,³, ENSP00000319756⁴	MINT-61566 I2D: score=2 STRING: ENSP00000319756
PDIA3	P30101²^,³	MINT-4301466 I2D: score=1
MYO10	Q9HD67²^,³, ENSP00000391106⁴	MINT-8199775 MINT-8199748 I2D: score=3 STRING: ENSP00000391106
ITGAV	P06756¹^,³, ENSP00000261023⁴	EBI-1223434,EBI-298282 I2D: score=4 STRING: ENSP00000261023

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006936	muscle contraction	TAS	--
GO:0007160	cell-matrix adhesion	IEA	--
GO:0007229	integrin-mediated signaling pathway	IEA	--

ITGB5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGB5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGB5
1 Novoseek chemical compound relationship for ITGB5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	15.5	3	7515874 (2)

Search CenterWatch for drugs/clinical trials and news about ITGB5 / ITB5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGB5 gene:

NM_002213.3

Unigene Cluster for ITGB5:

Integrin, beta 5

Hs.536663 [show with all ESTs]

Unigene Representative Sequence: AK091595

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296181(uc010hrx.3 uc003eho.3) ENST00000460797 ENST00000461306

ENST00000481591 ENST00000572186(uc003ehp.1) ENST00000488466 ENST00000474838

ENST00000496703 ENST00000476988 ENST00000465464 ENST00000483168

miRNA Products:		OriGene 3'-UTR Clone: ITGB5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGB5:
		hsa-miR-659 hsa-miR-548k hsa-miR-421 hsa-miR-3162-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB5 (see all 7) OriGene shRNA RFP: ITGB5 OriGene siRNA: ITGB5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ITGB5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGB5 (NM_002213)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB5

Additional cDNA sequence:

AK054968.1 AK091595.1 AK130168.1 AK309551.1 AK315429.1 BC006541.2 J05633.1 M35011.1

X53002.1

24 DOTS entries:

DT.441725 DT.452865 DT.92448283 DT.102833259 DT.100877190 DT.95275215 DT.100877185 DT.87002074

DT.100877179 DT.100877186 DT.102833258 DT.120860496 DT.120860508 DT.99938241 DT.120860544 DT.92448288

DT.100030466 DT.100690117 DT.120860477 DT.120860533 DT.120860549 DT.86995704 DT.40116835 DT.91679976

24/487 AceView cDNA sequences (see all 487):

CF619433 BP368420 BG765510 AI247496 AI989755 AW732475 CD517656 BF792119

M35011 BU617669 BQ277609 CB128712 CD558839 BG054483 BQ673891 AA434397

BU789544 BQ423878 AU279907 BM710288 AA345203 BU728502 AW025587 CB242657

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	·	16c	·
SP1:													-						-																						-		-
SP2:					-		-		-		-		-
SP3:
SP4:							-						-						-
SP5:													-

ExUns:	16d	^	17	^	18	^	19a	·	19b	^	20	^	21a	·	21b	^	22
SP1:			-				-
SP2:
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for ITGB5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGB5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGCTGCG

About this image

ITGB5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Early Embryo (Zygote)

Morula

8-Cell Embryo

Early Embryo

Early Embryo (Zygote)

Zygote

Early Embryo

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Bone

Mandibular Condyle

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Embryoid bodies (Generation and expan...)

Definitive endoderm-like cells (A scalable, suspensi...)

See ITGB5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGB5

SOURCE GeneReport for Unigene cluster: Hs.536663

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGB5:

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Focal Adhesions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGB5 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGB5¹	integrin, beta 5	73.91(n) 76.13(a)		395142 NM_204483.1 NP_989814.1
lizard (Anolis carolinensis)	Reptilia	ITGB5⁶ --	--	73(a) 60(a)	1 ↔ 1 possible ortholog	1(78157899-78226315) AAWZ02040349(988-1653)
zebrafish (Danio rerio)	Actinopterygii	wufi30h12²	wufi30h12	77.16(n)		334090 BI884761.1
fruit fly (Drosophila melanogaster)	Insecta	mys³	central nervous system development calcium-dependent more	40(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	pat-3³	beta integrin	38(a)		III(3981133-3985933) --

ENSEMBL Gene Tree for ITGB5 (if available)
TreeFam Gene Tree for ITGB5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGB5 gene

ITGB4² ITGB1² ENSG00000259753² ITGB2² ITGB7² ITGB3² ITGBL1² ITGB8²

ITGB6²

7 SIMAP similar genes for ITGB5 using alignment to 7 protein entries: ITB5_HUMAN (see all proteins):

ITGB3 ITGB1 ITGB6 ITGB8 ITGB2 ITGB7

ITGB4

ITGB5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs849019^1,2	C,F,O,H	--	124481461(-)	`CTTAAA/TCATCA`	1	--	int¹		28		MN NA NS EA WA CSA	1813
rs72970713^1,2	C	--	124481477(+)	`ACTTCG/CTGTGG`	1	--	int¹		1		WA	2
rs141873550^1,2		--	124481503(+)	`CCTTGC/TTTGTC`	1	--	int¹		0	--	--	--	--
rs116182279^1,2		--	124481506(+)	`TGCTTG/ATCTGT`	1	--	int¹		1		NA	120
rs199569115^1,2		--	124481541(+)	`TCAGA-/ACAAG GGAGGGAGACAAG`	1	--	int¹		0	--	--	--	--
rs80123536^1,2		--	124481542(+)	`TCAGAA/CCAAGG`	1	--	int¹		0	--	--	--	--
rs112020282^1,2	C	--	124481542(+)	`CAGAACAAGGGAG GGAGAC/-CAAGG`	1	--	int¹		1		CSA	2
rs71145487^1,2	C	--	124481548(-)	`ACCACCCCTTGGT CTCCCT/-CCCTT`	1	--	int¹		1		NA	2
rs138438169^1,2	C	--	124481609(+)	`AAAGG-/TATC TATCT`	1	--	int¹		0	--	--	--	--
rs3059020^1,2	C	--	124481614(+)	`TATCTATCT/- GCTCA`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for ITGB5 (124480795 - 124606674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ITGB5
4 CNVs: 98431 68440 68441 62095
1 Indel: 98432

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ITGB5 for disorders           About GeneDecksing

OMIM gene information: 147561    OMIM disorders: --

20/21 diseases for ITGB5 (see all 21):    About MalaCards

localized scleroderma cavernous malformation kaposi's sarcoma scleroderma

malignant glioma squamous cell carcinoma hepatitis b chondrosarcoma

breast cancer sarcoma colon carcinoma ovarian cancer

lung carcinoma carcinoma osteosarcoma lung cancer

obesity hepatitis cerebritis adenocarcinoma

3 Novoseek disease relationships for ITGB5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma	4.44	1	7551009 (1)
breast cancer	1.52	1	18550570 (1)
tumors	0	2	7551009 (1), 11746774 (1)

Human Genome Epidemiology (HuGE) Navigator: ITGB5 (6 documents)

Export disorders for ITGB5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITGB5 gene, integrated from 9 sources (see all 111):
(articles sorted by number of sources associating them with ITGB5)

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cDNA sequence of the human integrin beta 5 subunit. (PubMed id 2211615)^{1, 2, 3} McLean J.W.... Bodary S.C. (1990)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Myosin-X provides a motor-based link between integrins and the cytoskeleton. (PubMed id 15156152)^{1, 2} Zhang H....Stromblad S. (2004)
Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. (PubMed id 2371275)^{1, 2} Suzuki S.... Tanihara H. (1990)
Cloning, primary structure and properties of a novel human integrin beta subunit. (PubMed id 2328726)^{1, 2} Ramaswamy H. and Hemler M.E. (1990)
A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. (PubMed id 7689573)^{1, 9} Pasqualini R....Hemler M.E. (1993)
P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PubMed id 12356872)^{1, 9} Zhang H....Stromblad S. (2002)
Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. (PubMed id 1918165)^{1, 9} Adams J.C. and Watt F.M. (1991)
Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)^{1, 9} Brendle A....Forsti A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3693	HGNC: 6160	AceView: ITGB5	Ensembl:ENSG00000082781	euGenes: HUgn3693
ECgene: ITGB5	Kegg: 3693	H-InvDB: ITGB5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ITGB5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGB5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGB5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGB5 gene:
Search GeneIP for patents involving ITGB5

GeneCards and IP:
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