Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ITGB5 Gene

Aliases for ITGB5 Gene

  • Integrin Subunit Beta 5 2 3 5
  • Integrin, Beta 5 2

External Ids for ITGB5 Gene

Previous GeneCards Identifiers for ITGB5 Gene

  • GC03M121191
  • GC03M124498
  • GC03M125763
  • GC03M125802
  • GC03M125964
  • GC03M121856
  • GC03M124480

Summaries for ITGB5 Gene

GeneCards Summary for ITGB5 Gene

ITGB5 (Integrin Subunit Beta 5) is a Protein Coding gene. Diseases associated with ITGB5 include Villous Adenocarcinoma. Among its related pathways are VEGF Signaling Pathway and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ITGB3.

UniProtKB/Swiss-Prot for ITGB5 Gene

  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

  • (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Gene Wiki entry for ITGB5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB5 Gene

Genomics for ITGB5 Gene

Regulatory Elements for ITGB5 Gene

Enhancers for ITGB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F124829 1.2 FANTOM5 Ensembl ENCODE 40.9 +66.5 66513 11.4 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF143 ITGB5 UMPS ITGB5-AS1 KALRN ENO1P3 ENSG00000280042
GH03F124858 1.1 Ensembl ENCODE 38.2 +41.3 41318 4.6 TBP HDAC1 PKNOX1 ZNF133 SIN3A YY1 RFX5 RCOR1 FOS CREM ITGB5 ITGB5-AS1 ENO1P3 ENSG00000280042
GH03F124875 1.1 Ensembl ENCODE 37.5 +23.4 23430 5.6 PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 ZNF121 GATA2 FOS KLF13 ITGB5 ITGB5-AS1 MUC13 GC03M124774 ENO1P3
GH03F124849 1 Ensembl ENCODE 34.5 +50.5 50515 2.3 CTCF REST NR3C1 TBX21 RAD21 JUND SCRT2 IKZF1 SMC3 ZBTB33 ITGB5 ITGB5-AS1 ENO1P3 ENSG00000280042
GH03F124882 1 FANTOM5 ENCODE 27.5 +15.3 15267 8.0 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 ZNF263 SP3 ITGB5 ITGB5-AS1 MUC13 GC03M124774 GC03P124890
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ITGB5 on UCSC Golden Path with GeneCards custom track

Promoters for ITGB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001851796 117 600 ELF3 ATF1 NFRKB ARID4B SIN3A DMAP1 ZNF48 ZNF2 RAD21 RARA

Genomic Location for ITGB5 Gene

Chromosome:
3
Start:
124,761,948 bp from pter
End:
124,901,418 bp from pter
Size:
139,471 bases
Orientation:
Minus strand

Genomic View for ITGB5 Gene

Genes around ITGB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB5 Gene

Proteins for ITGB5 Gene

  • Protein details for ITGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18084-ITB5_HUMAN
    Recommended name:
    Integrin beta-5
    Protein Accession:
    P18084
    Secondary Accessions:
    • B0LPF8
    • B2RD70

    Protein attributes for ITGB5 Gene

    Size:
    799 amino acids
    Molecular mass:
    88054 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with NOV (PubMed:15611078).
    • (Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.

neXtProt entry for ITGB5 Gene

Post-translational modifications for ITGB5 Gene

  • Glycosylation at Thr 199, Asn 347, Asn 460, Asn 477, Asn 505, Asn 552, Asn 586, Asn 654, and Asn 705
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ITGB5 (Integrin beta 5)
  • Cell Signaling Technology (CST) Antibodies for ITGB5 (ITGB5)
  • Cloud-Clone Corp. Antibodies for ITGB5

No data available for DME Specific Peptides for ITGB5 Gene

Domains & Families for ITGB5 Gene

Gene Families for ITGB5 Gene

Suggested Antigen Peptide Sequences for ITGB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18084

UniProtKB/Swiss-Prot:

ITB5_HUMAN :
  • Contains 1 PSI domain.
  • Belongs to the integrin beta chain family.
Domain:
  • Contains 1 PSI domain.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB5: view

Function for ITGB5 Gene

Molecular function for ITGB5 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Gene Ontology (GO) - Molecular Function for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 1694173
genes like me logo Genes that share ontologies with ITGB5: view
genes like me logo Genes that share phenotypes with ITGB5: view

Animal Models for ITGB5 Gene

MGI Knock Outs for ITGB5:

Animal Model Products

miRNA for ITGB5 Gene

miRTarBase miRNAs that target ITGB5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGB5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB5 Gene

Localization for ITGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB5 Gene COMPARTMENTS Subcellular localization image for ITGB5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex IEA --
GO:0009986 cell surface IDA 7525578
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ITGB5: view

Pathways & Interactions for ITGB5 Gene

genes like me logo Genes that share pathways with ITGB5: view

SIGNOR curated interactions for ITGB5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 24036928
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928
genes like me logo Genes that share ontologies with ITGB5: view

Drugs & Compounds for ITGB5 Gene

(4) Drugs for ITGB5 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilengitide Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins, Potent and selective inhibitor of integrins alphavbeta3 and alphavbeta5 0
CNTO-95 Pharma 0
GLPG0187 Pharma 0

(1) ApexBio Compounds for ITGB5 Gene

Compound Action Cas Number
Cilengitide Integrin inhibitor for αvβ3 and αvβ5 188968-51-6
genes like me logo Genes that share compounds with ITGB5: view

Transcripts for ITGB5 Gene

Unigene Clusters for ITGB5 Gene

Integrin, beta 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGB5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ITGB5 Gene

GeneLoc Exon Structure for
ITGB5
ECgene alternative splicing isoforms for
ITGB5

Expression for ITGB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB5 Gene

This gene is overexpressed in Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for ITGB5 Gene

This gene is overexpressed in Liver (16.8) and Monocytes (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGB5 Gene



Protein tissue co-expression partners for ITGB5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGB5 Gene:

ITGB5

SOURCE GeneReport for Unigene cluster for ITGB5 Gene:

Hs.536663
genes like me logo Genes that share expression patterns with ITGB5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ITGB5 Gene

Orthologs for ITGB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB5 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia ITGB5 34 35
  • 89.45 (n)
dog
(Canis familiaris)
Mammalia ITGB5 34 35
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Itgb5 34 16 35
  • 86.82 (n)
rat
(Rattus norvegicus)
Mammalia Itgb5 34
  • 86.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ITGB5 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB5 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGB5 34 35
  • 74.58 (n)
lizard
(Anolis carolinensis)
Reptilia ITGB5 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216279 34
  • 68.14 (n)
zebrafish
(Danio rerio)
Actinopterygii itgb5 34 35
  • 67.79 (n)
wufi30h12 34
fruit fly
(Drosophila melanogaster)
Insecta mys 36
  • 40 (a)
bgrInt-ngr 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 36
  • 38 (a)
Species where no ortholog for ITGB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB5 Gene

ENSEMBL:
Gene Tree for ITGB5 (if available)
TreeFam:
Gene Tree for ITGB5 (if available)

Paralogs for ITGB5 Gene

genes like me logo Genes that share paralogs with ITGB5: view

Variants for ITGB5 Gene

Sequence variations from dbSNP and Humsavar for ITGB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049380 -- 124,768,596(+) AATAG(C/T)GTCCA intron-variant
rs1007611 -- 124,883,876(+) TGGCC(A/G)TAAGA intron-variant
rs1007856 -- 124,886,011(-) GCGGA(C/T)TTTCT intron-variant
rs1007857 -- 124,885,842(-) GAGGA(G/T)GGGTC intron-variant
rs1017813 -- 124,873,138(+) GTCTT(C/T)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB5 Gene

Variant ID Type Subtype PubMed ID
dgv8533n54 CNV gain+loss 21841781
dgv8534n54 CNV gain 21841781
dgv8535n54 CNV gain 21841781
dgv8536n54 CNV gain+loss 21841781
dgv8537n54 CNV gain 21841781
dgv8538n54 CNV loss 21841781
esv22852 CNV gain+loss 19812545
esv23075 CNV loss 19812545
esv2454361 CNV deletion 19546169
esv2607536 CNV insertion 19546169
esv2725850 CNV deletion 23290073
esv2725852 CNV deletion 23290073
esv3307663 CNV mobile element insertion 20981092
esv3332098 CNV duplication 20981092
esv3376769 CNV insertion 20981092
esv3398319 CNV insertion 20981092
esv3406650 CNV insertion 20981092
esv3562486 CNV deletion 23714750
esv9373 CNV loss 19470904
nsv1001677 CNV loss 25217958
nsv1012242 CNV gain 25217958
nsv1136770 CNV deletion 24896259
nsv1142370 CNV tandem duplication 24896259
nsv1144998 CNV deletion 24896259
nsv1160974 CNV duplication 26073780
nsv3981 CNV insertion 18451855
nsv591432 CNV loss 21841781
nsv591440 CNV gain 21841781
nsv591456 CNV loss 21841781
nsv820971 CNV deletion 20802225

Variation tolerance for ITGB5 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGB5 Gene

Human Gene Mutation Database (HGMD)
ITGB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB5 Gene

Disorders for ITGB5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ITGB5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
villous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ITGB5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGB5

Genetic Association Database (GAD)
ITGB5
Human Genome Epidemiology (HuGE) Navigator
ITGB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGB5
genes like me logo Genes that share disorders with ITGB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB5 Gene

Publications for ITGB5 Gene

  1. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PMID: 18550570) Brendle A. … FAPrsti A. (Carcinogenesis 2008) 3 22 46 64
  2. cDNA sequence of the human integrin beta 5 subunit. (PMID: 2211615) McLean J.W. … Bodary S.C. (J. Biol. Chem. 1990) 2 3 4 64
  3. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. (PMID: 20615244) Lyle C. … McCormick F. (Virol. J. 2010) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Role of genetic susceptibility to latent adenoviral infection and decreased lung function. (PMID: 19502044) Kasuga I. … Sandford A.J. (Respir Med 2009) 3 46 64

Products for ITGB5 Gene

Sources for ITGB5 Gene

Content
Loading form....