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ITGB5 Gene

protein-coding   GIFtS: 67
GCID: GC03M124480

Integrin, Beta 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Beta 51 2
Integrin Beta-52

External Ids:    HGNC: 61601   Entrez Gene: 36932   Ensembl: ENSG000000827817   OMIM: 1475615   UniProtKB: P180843   

Export aliases for ITGB5 gene to outside databases

Previous GC identifers: GC03M121191 GC03M124498 GC03M125763 GC03M125802 GC03M125964 GC03M121856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ITGB5 Gene:
ITGB5 (integrin, beta 5) is a protein-coding gene. GO annotations related to this gene include integrin binding and receptor activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084
Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

Gene Wiki entry for ITGB5 (Integrin, beta 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGB5 gene promoter:
         ER-alpha   AML1a   Pbx1a   Nkx2-5   Cdc5   NRF-2   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGB5 promoter sequence
   Search Chromatin IP Primers for ITGB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

ITGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M124480:  view genomic region     (about GC identifiers)

Start:
124,480,795 bp from pter      End:
124,620,265 bp from pter
Size:
139,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084 (See protein sequence)
Recommended Name: Integrin beta-5 precursor  
Size: 799 amino acids; 88054 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10.
Interacts with DAB2
Secondary accessions: B0LPF8 B2RD70

Explore the universe of human proteins at neXtProt for ITGB5: NX_P18084

Explore proteomics data for ITGB5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr199, Asn347, Asn460, Asn477, Asn505, Asn552, Asn586, Asn654, Asn705
  • Modification sites at PhosphoSitePlus

  • See ITGB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002204.2  
    ENSEMBL proteins: 
     ENSP00000296181   ENSP00000420814   ENSP00000477446   ENSP00000418367   ENSP00000418079  
     ENSP00000477230   ENSP00000419198   ENSP00000476655  
    Reactome Protein details: P18084

    ITGB5 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITGB5
    GenScript Custom Purified and Recombinant Proteins Services for ITGB5
    Novus Biologicals ITGB5 Proteins
    Novus Biologicals ITGB5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGB5 

     
    antibodies-online proteins for ITGB5 (8 products) 

     
    antibodies-online peptides for ITGB5

    ITGB5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB5
    R&D Systems Antibodies for ITGB5 (Integrin beta 5)
    Cell Signaling Technology (CST) Antibodies for ITGB5 
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    OriGene Custom Antibody Services for ITGB5
    Novus Biologicals ITGB5 Antibodies
    Abcam antibodies for ITGB5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGB5
    antibodies-online antibodies for ITGB5 (78 products) 

    ITGB5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGB5
    R&D Systems Proteome Profiler Antibody Arrays for ITGB5 (Integrin beta 5)
    GenScript Custom Assay Services for ITGB5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGB5 
    antibodies-online kits for ITGB5 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    Selected InterPro protein domains (see all 8):
     IPR002369 Integrin_bsu_N
     IPR000742 EG-like_dom
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P18084

    ProtoNet protein and cluster: P18084

    3 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB5_HUMAN, P18084
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB5_HUMAN, P18084
    Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005102receptor binding ----
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI1694173
         
    Find genes that share ontologies with ITGB5           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for ITGB5:
     Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgb5):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  normal  other  tumorigenesis 
     vision/eye 

    Find genes that share phenotypes with ITGB5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itgb5tm1Des for ITGB5

       genOway: Develop your customized and physiologically relevant rodent model for ITGB5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGB5:
    hsa-let-7b-5p (MIRT051994), hsa-mir-155-5p (MIRT020894), hsa-mir-335-5p (MIRT018321)

    Block miRNA regulation of human, mouse, rat ITGB5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ITGB5:
    hsa-miR-659 hsa-miR-548k hsa-miR-421 hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidITGB5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGB5
    Predesigned siRNA for gene silencing in human, mouse, rat ITGB5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITGB5

    Clone
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    OriGene ORF clones in mouse, rat for ITGB5
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    GenScript: all cDNA clones in your preferred vector: ITGB5 (NM_002213)
    Sino Biological Human cDNA Clone for ITGB5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB5
    Addgene plasmids for ITGB5 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGB5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITB5_HUMAN, P18084: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IEA--
    GO:0016020membrane ----
    GO:0031252cell leading edge IEA--

    Find genes that share ontologies with ITGB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGB5 About   (see all 36)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with ITGB5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGB5 (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 Cell Signaling Technology (CST) Pathways for ITGB5
        Angiogenesis
    Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ITGB5
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5 BioSystems Pathways for ITGB5
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by focal adhesion kinase


    Selected Reactome Pathways for ITGB5 (see all 6)
        Cross-presentation of particulate exogenous antigens (phagosomes)
    Molecules associated with elastic fibres
    ECM proteoglycans
    Integrin cell surface interactions
    Smooth Muscle Contraction

    1 PharmGKB Pathway for ITGB5
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for ITGB5) (see all 9):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB5: 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGB5 (P180841, 2, 3 ENSP000002961814) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8Q129292, 3, ENSP000002811724MINT-45899 I2D: score=3 STRING: ENSP00000281172
    TENC1Q63HR22, 3, ENSP000003197564MINT-61566 I2D: score=2 STRING: ENSP00000319756
    PDIA3P301012, 3MINT-4301466 I2D: score=1 
    MYO10Q9HD671, 2, 3, ENSP000003911064EBI-1223434,EBI-307061 MINT-8199775 MINT-8199748 I2D: score=3 STRING: ENSP00000391106
    ITGAVP067561, 3, ENSP000002610234EBI-1223434,EBI-298282 I2D: score=4 STRING: ENSP00000261023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006936muscle contraction TAS--
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    Find genes that share ontologies with ITGB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGB5 (ITB5)

    1 Novoseek inferred chemical compound relationship for ITGB5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 15.5 3 7515874 (2)



    Find genes that share compounds with ITGB5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGB5 gene: 
    NM_002213.3  

    Unigene Cluster for ITGB5:

    Integrin, beta 5
    Hs.536663  [show with all ESTs]
    Unigene Representative Sequence: AK091595
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296181(uc010hrx.3 uc003eho.3) ENST00000460797 ENST00000461306
    ENST00000481591 ENST00000488466 ENST00000474838 ENST00000496703 ENST00000476988
    ENST00000465464 ENST00000608657 ENST00000483168 ENST00000608107 ENST00000608945

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ITGB5:
    hsa-miR-659 hsa-miR-548k hsa-miR-421 hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidITGB5 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGB5 (NM_002213)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB5
    Addgene plasmids for ITGB5 
    Primer
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    OriGene qPCR primer pairs and template standards for ITGB5
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGB5
      QuantiTect SYBR Green Assays in human, mouse, rat ITGB5
      QuantiFast Probe-based Assays in human, mouse, rat ITGB5

    Additional mRNA sequence: 

    AK054968.1 AK091595.1 AK130168.1 AK309551.1 AK315429.1 BC006541.2 J05633.1 M35011.1 
    X53002.1 

    24 DOTS entries:

    DT.441725  DT.452865  DT.92448283  DT.102833259  DT.100877190  DT.95275215  DT.100877185  DT.87002074 
    DT.100877179  DT.100877186  DT.102833258  DT.120860496  DT.120860508  DT.99938241  DT.120860544  DT.92448288 
    DT.100030466  DT.100690117  DT.120860477  DT.120860533  DT.120860549  DT.86995704  DT.40116835  DT.91679976 

    Selected AceView cDNA sequences (see all 487):

    BF792119 BQ423878 BQ277609 CD742754 AA345203 BQ772919 CA454186 CA406325 
    CF125697 AW731726 CD558839 BG679228 AI755128 AI989755 BQ000043 CD517656 
    AL543371 BU197234 BQ278978 CF131340 CR609293 J05633 CF125033 AU279907 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
    SP1:                                      -                 -                                                                 -     -                           
    SP2:              -     -     -     -     -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -                 -                 -                                                                                                   
    SP5:                                      -                                                                                                                     

    ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
    SP1:        -           -                                 
    SP2:                                                      
    SP3:                    -                                 
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ITGB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCTGCG
    ITGB5 Expression
    About this image


    ITGB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 9 entries
             Odontoblasts Dentin
             Dental Enamel
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
    ITGB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.536663
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB5: 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ITGB5
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB5
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGB5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb51 , 5 integrin beta 51, 5 86.82(n)1
    91.74(a)1
      16 (24.22 cM)5
    164191  NM_001145884.11  NP_001139356.11 
     338296655 
    chicken
    (Gallus gallus)
    Aves ITGB51 integrin, beta 5 74.58(n)
    77.03(a)
      395142  NM_204483.1  NP_989814.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGB56
    integrin, beta 5
    73(a)
    1 ↔ 1
    1(78142882-78227422)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1002162791 uncharacterized LOC100216279 68.14(n)
    68.73(a)
      100216279  NM_001142232.1  NP_001135704.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi30h122 wufi30h12 77.16(n)   334090  BI884761.1 


    ENSEMBL Gene Tree for ITGB5 (if available)
    TreeFam Gene Tree for ITGB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGB5 gene
    ITGB42  ITGB12  ENSG000002597532  ITGB72  ITGB22  ITGBL12  ITGB32  ITGB82  
    ITGB62  
    7 SIMAP similar genes for ITGB5 using alignment to 10 protein entries:     ITB5_HUMAN (see all proteins):
    ITGB3    ITGB1    ITGB6    ITGB8    ITGB7    ITGB2
    ITGB4

    Find genes that share paralogs with ITGB5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGB5 (see all 2721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8490191,2
    C,F,O,H--124481461(-) CTTAAA/TCATCA 1 -- int128Minor allele frequency- T:0.37MN NA NS EA WA CSA 1813
    rs729707131,2
    C,F--124481477(+) ACTTCG/CTGTGG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1116695791,2
    C--124481480(+) TCGTGG/TGGGAA 1 -- int10--------
    rs1418735501,2
    --124481503(+) CCTTGC/TTTGTC 1 -- int10--------
    rs1161822791,2
    C,F--124481506(+) TGCTTG/ATCTGT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1995691151,2
    --124481541(+) TCAGA-/ACAAG 
    GGAGGGAG
    ACAAG
    1 -- int10--------
    rs801235361,2
    C--124481542(+) TCAGAA/CCAAGG 1 -- int10--------
    rs1120202821,2
    C--124481542(+) CAGAACAAGGGAG
    GGAGAC
    /-
    CAAGG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs711454871,2
    C--124481548(-) ACCACCCCTTGGT
    CTCCCT
    /-
    CCCTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1384381691,2
    C--124481609(+) AAAGG-/TATC  
            
    TATCT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGB5 (124480795 - 124620265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGB5 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725850CNV Deletion23290073
    esv2454361CNV Deletion19546169
    esv2725852CNV Deletion23290073
    nsv820971CNV Deletion20802225
    esv2607536CNV Insertion19546169
    esv271937CNV Insertion20981092
    nsv3981CNV Insertion18451855
    esv23075CNV Loss19812545
    nsv877404CNV Loss21882294
    nsv877403CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGB5
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147561    OMIM disorders: --


    Find genes that share disorders with ITGB5           About GenesLikeMe

    3 Novoseek inferred disease relationships for ITGB5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 4.44 1 7551009 (1)
    breast cancer 1.52 1 18550570 (1)
    tumors 0 2 7551009 (1), 11746774 (1)

    Genetic Association Database (GAD): ITGB5
    Human Genome Epidemiology (HuGE) Navigator: ITGB5 (6 documents)

    Export disorders for ITGB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGB5 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with ITGB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence of the human integrin beta 5 subunit. (PubMed id 2211615)1, 2, 3 McLean J.W.... Bodary S.C. (J. Biol. Chem. 1990)
    2. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)1, 4, 9 Brendle A....FAPrsti A. (Carcinogenesis 2008)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Role of genetic susceptibility to latent adenoviral infection and decreased lung function. (PubMed id 19502044)1, 4 Kasuga I....Sandford A.J. (Respir Med 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Myosin-X provides a motor-based link between integrins and the cytoskeleton. (PubMed id 15156152)1, 2 Zhang H.... Stromblad S. (Nat. Cell Biol. 2004)
    8. Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. (PubMed id 2371275)1, 2 Suzuki S.... Tanihara H. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    9. Cloning, primary structure and properties of a novel human integrin beta subunit. (PubMed id 2328726)1, 2 Ramaswamy H. and Hemler M.E. (EMBO J. 1990)
    10. A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. (PubMed id 7689573)1, 9 Pasqualini R....Hemler M.E. (J. Cell. Sci. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3693 HGNC: 6160 AceView: ITGB5 Ensembl:ENSG00000082781 euGenes: HUgn3693
    ECgene: ITGB5 Kegg: 3693 H-InvDB: ITGB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGB5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGB5 gene:
    Search GeneIP for patents involving ITGB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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