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ITGB3 Gene

protein-coding   GIFtS: 69
GCID: GC17P045331

Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61)


(Previous symbol: GP3A)
  See ITGB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61)1 2     GT2 5
GP3A1 2 3 5     Platelet Glycoprotein IIIa1
Platelet Membrane Glycoprotein IIIa2 3     CD612
GPIIIa2 3     Integrin Beta-32
BDPLT162 5     CD61 Antigen3
BDPLT22 5     

External Ids:    HGNC: 61561   Entrez Gene: 36902   Ensembl: ENSG000002592077   OMIM: 1734705   UniProtKB: P051063   

Export aliases for ITGB3 gene to outside databases

Previous GC identifers: GC17P044829 GC17P047729 GC17P045673 GC17P045805 GC17P042686 GC17P040709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGB3 Gene:
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed
of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different
integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to
participate in cell adhesion as well as cell-surface mediated signalling. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGB3 Gene:
ITGB3 (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)) is a protein-coding gene. Diseases associated with ITGB3 include thrombasthenia of glanzmann and naegeli, itgb3-related, and fetal and neonatal alloimmune thrombocytopenia. GO annotations related to this gene include cell adhesion molecule binding and identical protein binding. An important paralog of this gene is ITGBL1.

UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106
Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2,
osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin
alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and
vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of
ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of
soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial
surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance
angiogenesis in Kaposi's sarcoma lesions

summary for ITGB3 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGB3 (CD61) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGB3 gene promoter:
         ER-alpha   PPAR-gamma1   PPAR-gamma2   NF-kappaB   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGB3 promoter sequence
   Search Chromatin IP Primers for ITGB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

ITGB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045331:  view genomic region     (about GC identifiers)

Start:
45,331,208 bp from pter      End:
45,421,658 bp from pter
Size:
90,451 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106 (See protein sequence)
Recommended Name: Integrin beta-3 precursor  
Size: 788 amino acids; 87058 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform
Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following
platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with
MYO10. Interacts with DAB2. Interacts with FERMT2. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8
glycoprotein B and acts as a receptor for the virus
Selected PDB 3D structures from and Proteopedia for ITGB3 (see all 51):
1JV2 (3D)        1KUP (3D)        1KUZ (3D)        1L5G (3D)        1M1X (3D)        1M8O (3D)    
Secondary accessions: A0PJW2 D3DXJ8 O15495 Q12806 Q13413 Q14648 Q16499
Alternative splicing: 3 isoforms:  P05106-1   P05106-2   P05106-3   

Explore the universe of human proteins at neXtProt for ITGB3: NX_P05106

Explore proteomics data for ITGB3 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in
    outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are
    phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding1
  • Glycosylation2 at Asn125, Asn346, Asn397, Asn478, Asn585, Asn680
  • Modification sites at PhosphoSitePlus

  • See ITGB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000203.2  
    ENSEMBL proteins: 
     ENSP00000452786   ENSP00000461626   ENSP00000465586   ENSP00000407801  
    Reactome Protein details: P05106

    ITGB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGB3
    OriGene Protein Over-expression Lysate for ITGB3
    OriGene MassSpec for ITGB3
    OriGene Custom Protein Services for ITGB3
    GenScript Custom Purified and Recombinant Proteins Services for ITGB3
    Novus Biologicals ITGB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGB3 

     
    antibodies-online proteins for ITGB3 (6 products) 

     
    antibodies-online peptides for ITGB3

    ITGB3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB3
    R&D Systems Antibodies for ITGB3 (Integrin beta 3/CD61)
    Cell Signaling Technology (CST) Antibodies for ITGB3 
    OriGene Antibodies for ITGB3
    OriGene Custom Antibody Services for ITGB3
    Novus Biologicals ITGB3 Antibodies
    Abcam antibodies for ITGB3 (P08514, P05106, P06756)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGB3
    antibodies-online antibodies for ITGB3 (379 products) 

    ITGB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGB3
    R&D Systems Proteome Profiler Antibody Arrays for ITGB3 (Integrin beta 3/CD61)
    GenScript Custom Assay Services for ITGB3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGB3 
    antibodies-online kits for ITGB3 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    Selected InterPro protein domains (see all 7):
     IPR027068 Integrin_beta-3
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P05106

    ProtoNet protein and cluster: P05106

    3 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002035 Von Willebrand factor type A domain signature
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB3_HUMAN, P05106
    Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2,
    osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin
    alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and
    vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of
    ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
    Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of
    soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial
    surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance
    angiogenesis in Kaposi's sarcoma lesions

         Genatlas biochemistry entry for ITGB3:
    integrin,beta 3,platelet glycoprotein IIIa,Pen alloantigen,Sra alloantigen,involved in neonatal alloimmune
    thrombocytopenia and post-transfusion purpura,cell surface adhesion receptor mediating cell-adhesion to extra
    cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various
    signaling molecules within cells,contributor,in association with PAI1 in susceptibility to myocardial infarction
    in Finnish population (see PAI1)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IDA12204115
    GO:0004872receptor activity IEA--
    GO:0005161platelet-derived growth factor receptor binding TAS19267251
    GO:0005515protein binding IPI10822899
    GO:0042802identical protein binding IPI11606749
         
    Find genes that share ontologies with ITGB3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITGB3:
     Decreased focal adhesion (FA)   Increased G2M DNA content 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Itgb3) (see all 20):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  normal  other  renal/urinary system 

    Find genes that share phenotypes with ITGB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ITGB3: Itgb3tm1Hyn Itgb3tm1Aja

       genOway: Develop your customized and physiologically relevant rodent model for ITGB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGB3:
    hsa-mir-98-5p (MIRT048710), hsa-mir-204-5p (MIRT005833), hsa-let-7a-5p (MIRT000708), hsa-mir-30c-5p (MIRT007133)

    Block miRNA regulation of human, mouse, rat ITGB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGB3 (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7g hsa-miR-372 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidITGB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGB3
    Predesigned siRNA for gene silencing in human, mouse, rat ITGB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGB3

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGB3 (see all 6)
    OriGene ORF clones in mouse, rat for ITGB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGB3 (NM_000212)
    Sino Biological Human cDNA Clone for ITGB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB3
    Addgene plasmids for ITGB3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12358) for ITGB3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITB3_HUMAN, P05106: Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane.
    Cell junction, focal adhesion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular3
    cytoskeleton2
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2452834
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IDA15215180

    Find genes that share ontologies with ITGB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGB3 About   (see all 59)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with ITGB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGB3
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGB3 (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for ITGB3
        Angiogenesis
    Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for ITGB3 (see all 6)
        Development VEGF-family signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Development VEGF signaling via VEGFR2 - generic cascades
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin inside-out signaling

    Selected BioSystems Pathways for ITGB3 (see all 17)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Monoamine Transport
    Serotonin Transporter Activity
    Arrhythmogenic right ventricular cardiomyopathy


    Selected Reactome Pathways for ITGB3 (see all 11)
        Integrin cell surface interactions
    Elastic fibre formation
    PECAM1 interactions
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Integrins

    2 PharmGKB Pathways for ITGB3
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for ITGB3) (see all 14):
        Rap1 signaling pathway
    Phagosome
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB3 (see all 9): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGB3

    Selected Interacting proteins for ITGB3 (P051061, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA2BP085141, 2, 3EBI-702847,EBI-702693 MINT-7261217 MINT-7261157 MINT-7261259 MINT-7261298 MINT-7261237 MINT-7261175 MINT-7261198 MINT-7261279 I2D: score=6 
    TLN1Q9Y4901, 2, 3EBI-702847,EBI-2462036 MINT-1795071 MINT-1795026 MINT-2793444 MINT-1795056 I2D: score=4 
    PTPN1P180311, 2, 3EBI-702847,EBI-968788 MINT-6794826 MINT-6794817 MINT-6795286 MINT-6794843 I2D: score=1 
    ITGAVP067561, 2, 3EBI-702847,EBI-298282 MINT-8216018 MINT-8216025 MINT-25081 I2D: score=5 
    SRCP129312, 3MINT-6795286 MINT-6794843 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation TAS19267251
    GO:0001938positive regulation of endothelial cell proliferation IMP10022831
    GO:0002576platelet degranulation TAS--
    GO:0006457protein folding IDA12204115
    GO:0007044cell-substrate junction assembly IEA--

    Find genes that share ontologies with ITGB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ITGB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    4 DrugBank Compounds for ITGB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EptifibatideIntegrelin (see all 2)188627-80-7target--12360110 12928738 15860200 14617694 10592235 14618072 11588534
    Abciximab7E3 (see all 4)143653-53-6targetantagonist17441904 18510478 11752352 12749745 11588534 12165285
    Tirofiban-- 144494-65-5targetantagonist11752352 20210689 10592235
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600

    Selected Novoseek inferred chemical compound relationships for ITGB3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 78 55 1706596 (4), 1957276 (3), 1705115 (2), 8317479 (2) (see all 38)
    sele 61.7 2 11714857 (1), 15076187 (1)
    adp 61 19 8547151 (1), 16769603 (1), 2064610 (1), 1412224 (1) (see all 8)
    ristocetin 59.9 1 16769603 (1)
    rhodostomin 50.6 2 8611404 (2)
    1,25 dihydroxy vitamin d3 33.7 1 10913332 (1)
    aspirin 24.7 6 10725977 (3), 17559347 (1), 19703819 (1)
    tyrosine 14.4 9 8581996 (3), 8547151 (1), 7526955 (1), 10863474 (1) (see all 6)
    phosphatidylserine 6.83 1 17334510 (1)
    diethylstilbestrol 5.01 1 7750590 (1)

    2 PharmGKB related drug/compound annotations for ITGB3 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    clopidogrelCA  



    Find genes that share compounds with ITGB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGB3 gene: 
    NM_000212.2  

    Unigene Cluster for ITGB3:

    Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
    Hs.218040  [show with all ESTs]
    Unigene Representative Sequence: NM_000212
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559488 ENST00000571680(uc002ili.1) ENST00000573377 ENST00000435993(uc010wkr.1)

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    hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7g hsa-miR-372 hsa-miR-30a
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    Additional mRNA sequence: 

    AY826979.1 BC127666.1 BC127667.1 J02703.1 KC120777.1 KC120778.1 M20311.1 M25108.1 
    M35999.1 S70348.1 U95204.1 

    4 DOTS entries:

    DT.315192  DT.303692  DT.92425123  DT.86852546 

    Selected AceView cDNA sequences (see all 140):

    NM_000212 BF058953 CD364451 BX482144 BU174383 BM931908 AA954500 BU155897 
    BM719625 BQ437000 M25108 R81611 BF593562 R12504 BF115658 BE674065 
    BU628207 AA320129 BX646581 BG477276 BX474890 AI299955 BV180691 AA363345 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ITGB3 Expression
    About this image


    ITGB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Megakaryocytes Hematopoietic Bone Marrow
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
             Peripheral blood-derived endothelial progenitor cells
    ITGB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.218040

    UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106
    Tissue specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically
    expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB3 (see all 9): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgb31 , 5 integrin beta 31, 5 86.62(n)1
    90.72(a)1
      11 (67.84 cM)5
    164161  NM_016780.21  NP_058060.21 
     1046080005 
    chicken
    (Gallus gallus)
    Aves ITGB31 integrin, beta 3 (platelet glycoprotein IIIa, antigen more 79.07(n)
    83.25(a)
      374209  NM_204315.1  NP_989646.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Integrin beta
    82(a)
    1 → many
    6(65791773-65817912)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3976992 integrin beta-3 subunit 75.8(n)    L13591.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itgb3b1 integrin beta 3b 68.82(n)
    70.98(a)
      100001836  NM_001082948.1  NP_001076417.1 


    ENSEMBL Gene Tree for ITGB3 (if available)
    TreeFam Gene Tree for ITGB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGB3 gene
    ITGBL12  ITGB42  ITGB82  ITGB62  ITGB12  ENSG000002597532  ITGB52  ITGB72  
    ITGB22  
    9 SIMAP similar genes for ITGB3 using alignment to 14 protein entries:     ITB3_HUMAN (see all proteins):
    integrin beta 3    ITGB5    ITGB6    ITGB7    ITGB8    ITGB1
    ITGB2    ITGB4    TENM2

    Find genes that share paralogs with ITGB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ITB3_HUMAN, P05106: Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)).
    HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59. HPA-1A is involved in fetal-maternal
    alloimmune thromobocytopenia (FMAIT) as well as in neonatal alloimmune thrombocytopenia (NAIT)
    ITB3_HUMAN, P05106: Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK).
    HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune
    thrombocytopenia (NAIT or NATP)
    ITB3_HUMAN, P05106: Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433 and MO(+) has
    Ala-433. MO(+) is involved in NAIT
    ITB3_HUMAN, P05106: Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has Arg-515 and
    CA(+)/TU(+) has Gln-515. CA(+) is involved in NAIT
    ITB3_HUMAN, P05106: Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has Arg-662 and
    SR(A)(+) has Cys-662


    Selected SNPs for ITGB3 (see all 1359)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133064761,2,,4
    HGlanzmann thrombasthenia (GT)4 --46378916(+) CAATCA/CTTACT 2 H P mis16Minor allele frequency- C:0.00NS EA NA 420
    VAR_0699214
    Glanzmann thrombasthenia (GT)4--see VAR_0699212 M R mis40--------
    VAR_0304734
    Glanzmann thrombasthenia (GT)4--see VAR_0304732 R W mis40--------
    VAR_0106714
    Glanzmann thrombasthenia (GT)4--see VAR_0106712 C R mis40--------
    VAR_0699224
    Glanzmann thrombasthenia (GT)4--see VAR_0699222 G D mis40--------
    VAR_0040004
    Glanzmann thrombasthenia (GT)4--see VAR_0040002 R W mis40--------
    VAR_0304754
    Glanzmann thrombasthenia (GT)4--see VAR_0304752 D N mis40--------
    VAR_0304854
    Glanzmann thrombasthenia (GT)4--see VAR_0304852 C R mis40--------
    VAR_0699244
    Bleeding disorder, platelet-type 16 (BDPLT16)4--see VAR_0699242 D H mis40--------
    VAR_0304834
    Glanzmann thrombasthenia (GT)4--see VAR_0304832 I N mis40--------

    HapMap Linkage Disequilibrium report for ITGB3 (45331208 - 45421658 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ITGB3: --
    Human Gene Mutation Database (HGMD): ITGB3
    Locus Specific Mutation Databases (LSDB): ITGB3

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ITGB3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 173470   
    OMIM disorders: 273800  608446  187800  
    UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is
    characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into
    types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and
    lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at
    reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital
    macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected
    individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet
    functional abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for ITGB3 (see all 27):    
    About MalaCards
    thrombasthenia of glanzmann and naegeli, itgb3-related    fetal and neonatal alloimmune thrombocytopenia    thrombocytopenia, neonatal alloimmune    purpura, posttransfusion
    arteritic anterior ischemic optic neuropathy    thrombasthenia    bleeding disorder, platelet-type, 16, autosomal dominant    coronary thrombosis
    glanzmann's thrombasthenia    non-arteritic anterior ischemic optic neuropathy    central retinal artery occlusion    macrothrombocytopenia, autosomal dominant, tubb1-related
    autoimmune thrombocytopenic purpura    purpura    phimosis    calpainopathy
    hemorrhagic fever with renal syndrome    retinal artery occlusion    carotid intimal medial thickness    myocardial infarction

    8 diseases from the University of Copenhagen DISEASES database for ITGB3:
    Glanzmann's thrombasthenia     Thrombocytopenia     Myelofibrosis     Autoimmune thrombocytopenic purpura
    Bernard-Soulier syndrome     Leukemia     Myocardial infarction     Coronary heart disease

    Find genes that share disorders with ITGB3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGB3 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 93.7 24 20020534 (2), 1635160 (1), 8201919 (1), 2014236 (1) (see all 23)
    coagulopathy 60.8 3 20020534 (1), 9160670 (1), 9695977 (1)
    thrombocytopenia 59.2 15 18070277 (2), 8541531 (1), 10859334 (1), 18208809 (1) (see all 11)
    erythroleukemia 55.6 3 8876221 (1), 7662966 (1)
    coronary thrombosis 41.8 3 10589700 (1), 11028489 (1), 10521390 (1)
    arterial thrombosis 38.6 2 15166939 (1), 16793667 (1)
    thrombosis 33.6 3 18208809 (2), 15166939 (1)
    purpura thrombocytopenic idiopathic 31.3 1 17272505 (1)
    purpura thrombocytopenic 30.9 2 10697532 (1)
    myeloproliferative disorders 27.1 1 8819897 (1)

    Genatlas disease: ITGB3
    Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

    Genetic Association Database (GAD): ITGB3
    Human Genome Epidemiology (HuGE) Navigator: ITGB3 (269 documents)

    Export disorders for ITGB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGB3 gene, integrated from 10 sources (see all 1148):
    (articles sorted by number of sources associating them with ITGB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia. (PubMed id 12036875)1, 2, 4 Jallu V.... Kaplan C. (Blood 2002)
    2. ITGB3 shows genetic and expression interaction with SLC6A4. (PubMed id 16721604)1, 4, 9 Weiss L.A....Cook E.H. (Hum. Genet. 2006)
    3. Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. (PubMed id 15834589)1, 4, 9 Weiss L.A....Ober C. (Hum. Genet. 2005)
    4. An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system. (PubMed id 1430225)1, 2, 9 Wang R....Newman P.J. (J. Clin. Invest. 1992)
    5. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. (PubMed id 17556058)1, 4, 9 Thompson E.E....Ober C. (J. Allergy Clin. Immunol. 2007)
    6. A2 alelle of GpIIIa gene is a risk factor for stroke caused by large-vessel disease in males. (PubMed id 15178823)1, 4, 9 Slowik A....Szczudlik A. ( a journal of cerebral circulation 2004)
    7. Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia. (PubMed id 10233432)1, 2, 9 Ruan J....Nurden A.T. (Br. J. Haematol. 1999)
    8. A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa. (PubMed id 8132570)1, 2, 9 Santoso S.... Newman P.J. (J. Biol. Chem. 1994)
    9. Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system. (PubMed id 7694683)1, 2, 9 Wang R.... Newman P.J. (Blood 1993)
    10. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. (PubMed id 17203304)1, 4, 9 Coutinho A.M....Vicente A.M. (Hum. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3690 HGNC: 6156 AceView: ITGB3 Ensembl:ENSG00000259207 euGenes: HUgn3690
    ECgene: ITGB3 Kegg: 3690 H-InvDB: ITGB3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ITGB3[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ITGB3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGB3 gene:
    Search GeneIP for patents involving ITGB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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