 |
 | Services
| |
 |
Aliases &
Descriptions
for ITGB3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CD61 1, 2 | | GP3A 2, 3, 5 | | GPIIIa 1, 2, 3 |
| | | Descriptions |
|---|
| CD61 antigen 3 | | Platelet membrane glycoprotein IIIa 3 | | integrin beta chain, beta 3 2 | | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2 | | platelet glycoprotein IIIa 2 |
|
| |
Search outside databases for aliases for ITGB3 genePrevious GC identifers: GC17P044829 GC17P047729 GC17P045673 GC17P045805 |
Summaries
for ITGB3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ITGB3:
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface
proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple
partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain
in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated
signalling. [provided by RefSeq]
UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix
metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von
Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen,
plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and
alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3
recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation
integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble
fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured
endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat
protein seems to enhance angiogenesis in Kaposi's sarcoma lesionsGene Wiki entry for ITGB3 (CD61) |
Genomic Location
for ITGB3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the ITGB3 gene 
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32ITGB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P042686:
(about GC identifiers)
Start:
|
42,686,207 bp from pter |
End:
|
42,745,076 bp from pter |
Size:
|
58,870 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010783.14
| Proteins
for ITGB3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106 (See
protein sequence)Recommended Name: Integrin beta-3 precursor Size: 788 amino acids; 87058 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or
alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from  and Proteopedia  :1JV2 (3D)
1KUP (3D)
1KUZ (3D)
1L5G (3D)
1M1X (3D)
1M8O (3D)
1MK7 (3D)
1MK9 (3D)
1RN0 (3D)
1S4X (3D)
1TYE (3D)
1U8C (3D)
2INI (3D)
2K9J (3D)
2Q6W (3D)
2RMZ (3D)
2RN0 (3D)
2VC2 (3D)
2VDK (3D)
2VDL (3D)
2VDM (3D)
2VDN (3D)
2VDO (3D)
2VDP (3D)
2VDQ (3D)
2VDR (3D)
3FCS (3D)
3FCU (3D)
Secondary accessions: A0PJW2 O15495 Q12806 Q13413 Q14648 Q16499Alternative splicing: 3 isoforms: P05106-1 P05106-2 P05106-3 Post-translational modifications:
Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably
involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both
Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000203.2
ENSEMBL proteins: ENSP00000262017
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ITGB3:
Assays for ITGB3: | Protein
Domains/
Families
for ITGB3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P05106
ProtoNet protein and cluster: P05106 3 Blocks protein families: IPB001169 Integrin beta IPB002035 Von Willebrand factor type A domain signature IPB002369 Integrin beta subunit signature
UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106Similarity: Belongs to the integrin beta chain familySimilarity: Contains 1 VWFA domain | Gene Function
for ITGB3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000212
 Applied Biosystems Silencer® siRNAs for ITGB3
 Sigma-Aldrich siRNA and siRNA Panels for ITGB3
Sigma-Aldrich shRNA Panels and shRNA for ITGB3
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000212
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000212
untagged cDNA clone in CMV expression vector: NM_000212
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_000212
UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix
metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von
Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen,
plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and
alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3
recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation
integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble
fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured
endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat
protein seems to enhance angiogenesis in Kaposi's sarcoma lesionsGenatlas biochemistry entry for ITGB3:integrin,beta 3,platelet glycoprotein IIIa,Pen alloantigen,Sra alloantigen,involved in neonatal
alloimmune thrombocytopenia and post-transfusion purpura,cell surface adhesion receptor mediating
cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and
connecting to the cytoskeleton and various signaling molecules within cells,contributor,in
association with PAI1 in susceptibility to myocardial infarction in Finnish population (see PAI1)15 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Itgb3):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for ITGB3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ITGB3 (Your Favorite Gene powered by Ingenuity) (see all 8
)
Gene Network CentralTM Interacting Genes and Proteins Network for ITGB3
5/238 Interacting proteins for ITGB3 (P051061, 2 ENSP000002620173) via UniProtKB, MINT, and/or STRING (see all 238
)About this table
5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
): About this table
|
Drugs & Compounds
for ITGB3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Compounds for ITGB3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| RGDS peptide | Integrin binding sequence; inhibits integrin receptor function | [91037-65-9] | | MNS | Selective inhibitor of Src and Syk | [1485-00-3] | | Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitor | [154303-05-6] | | GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (alphaIIbbeta3) receptor antagonist. Antithrombotic | [201304-22-5] |
About this table
10/18  Novoseek chemical compound relationships for ITGB3 gene (see all 18
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fibrinogen |
78.19 |
49 |
1706596 (4), 1957276 (3), 1705115 (2), 8317479 (2) (see all 35) |
| sele |
63.35 |
2 |
11714857 (1), 15076187 (1) |
| adp |
57.50 |
15 |
8547151 (1), 16769603 (1), 2064610 (1), 1412224 (1) (see all 7) |
| 1,25 dihydroxy vitamin d3 |
34.78 |
1 |
10913332 (1) |
| tyrosine |
16.21 |
9 |
8581996 (3), 8547151 (1), 7526955 (1), 10863474 (1) (see all 6) |
| iron |
4.50 |
1 |
9460806 (1) |
| lipid |
2.11 |
1 |
19350519 (1) |
| cystine |
1.49 |
1 |
2064610 (1) |
| glucose |
1.08 |
1 |
17357883 (1) |
| atp |
0.00 |
1 |
1650365 (1) |
About this table
2 PharmGKB drug compound relationships for ITGB3 geneAbout this table
|
Transcripts
for ITGB3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000212
Sigma-Aldrich siRNA and siRNA Panels for ITGB3
Sigma-Aldrich shRNA Panels and shRNA for ITGB3
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_000212 REFSEQ mRNAs for ITGB3 gene: NM_000212.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000212
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000212
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000212
untagged cDNA clone in CMV expression vector: NM_000212
Additional cDNA sequence: AY826979.1 BC127666.1 BC127667.1 J02703.1 M20311.1 M25108.1 M35999.1 S70348.1 U95204.1 4 DOTS entries: DT.315192 DT.303692 DT.92425123 DT.86852546 24/140 AceView cDNA sequences (see all 140
):BF058953 AA320129 BU628207 BM719625 BQ437000 NM_000212 BU155897 BF593562 BE674065 BU174383 CD364451 BM931908 M25108 R81611 BX482144 R12504 AA954500 BF115658 M35999 AI458981 AI139583 AA669840 M20311 AI189839
 highest scoring ESTs for ITGB3:M35999 AA306373 AA320129 AA363345 AI151449 AI458981 AI470563 AI808178 AL702773 AU116912 Unigene Cluster for ITGB3: Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Hs.218040 [show with all ESTs]Unigene Representative Sequence: NM_000212
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000262017
|
Expression
for ITGB3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ITGB3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ITGB3
1 / 2 / 3 17 probe-sets matching ITGB3 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.218040
Expression variation in blood from EXPOLDB for ITGB3 UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106Tissue specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is
specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate
and testis |
Orthologs
for ITGB3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ITGB3 gene from 5/9 species (see all 9
)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
ITGB31 |
-- |
integrin, beta 3 (platelet glycoprotein IIIa, antigen more |
91.36(n)
95.53(a) |
403788 NM_001003162.1 NP_001003162.1 |
chimpanzee
(Pan troglodytes) |
ITGB31 |
-- |
integrin, beta 3 (platelet glycoprotein IIIa, antigen more |
99.53(n)
99.75(a) |
468295 XM_523684.2 XP_523684.2 |
cow
(Bos taurus) |
ITGB31 |
-- |
integrin, beta 3 (platelet glycoprotein IIIa, antigen more |
90.63(n)
95.4(a) |
282642 XM_616376.3 XP_616376.2 |
mouse
(Mus musculus) |
Itgb31, 5 |
11 (68.00 cM)5
|
integrin beta 31, 5 |
86.49(n)1
90.66(a)1 |
164161 NM_016780.11 NP_058060.11
AF0265095 AF0265105 (see all 16) |
chicken
(Gallus gallus) |
ITGB31 |
-- |
integrin, beta 3 (platelet glycoprotein IIIa, antigen more |
78.66(n)
82.66(a) |
374209 NM_204315.1 NP_989646.1 |
About this table Species with no ortholog for ITGB3
ENSEMBL Gene Tree for ITGB3 | Paralogs
for ITGB3(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ITGB3 gene
- ITGB82 ITGB62 ITGB52
|
SNPs/Variants
for ITGB3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106Polymorphism: Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)).
HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59Polymorphism: Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK).
HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in
neonatal alloimmune thrombocytopenia (NAIT or NATP)Polymorphism: Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433
and MO(+) has Ala-433. MO(+) is involved in NAITPolymorphism: Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has
Arg-515 and CA(+)/TU(+) has Gln-515. CA(+) is involved in NAITPolymorphism: Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has
Arg-662 and SR(A)(+) has Cys-662
HapMap Linkage Disequilibrium images for ITGB3 (up to first 250kb)
|
Disorders & Mutations
for ITGB3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 173470 UniProtKB/Swiss-Prot: ITB3_HUMAN, P05106
Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as
thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its
inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of
mild-to-moderate severity and the inability of this integrin to recognize macromolecular or
synthetic peptide ligands. GT has been classified clinically into types I and II. In type I,
platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen
and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at
reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate
clot retraction capability. The platelets of GT variants have normal or near normal (60-100%)
expression of dysfunctional receptors10/44 Novoseek disease relationships for ITGB3 gene (see all 44
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glanzmann thrombasthenia |
93.29 |
20 |
1635160 (1), 8201919 (1), 2014236 (1), 16463284 (1) (see all 20) |
| thrombocytopenia |
60.49 |
15 |
18070277 (2), 8541531 (1), 10859334 (1), 18208809 (1) (see all 11) |
| coagulopathy |
56.86 |
2 |
9160670 (1), 9695977 (1) |
| erythroleukemia |
56.40 |
3 |
8876221 (1), 7662966 (1) |
| coronary thrombosis |
43.00 |
3 |
10589700 (1), 11028489 (1), 10521390 (1) |
| arterial thrombosis |
40.13 |
2 |
15166939 (1), 16793667 (1) |
| thrombosis |
35.44 |
3 |
18208809 (2), 15166939 (1) |
| purpura thrombocytopenic |
32.72 |
2 |
10697532 (1) |
| purpura thrombocytopenic idiopathic |
32.60 |
1 |
17272505 (1) |
| myeloproliferative disorders |
28.72 |
1 |
8819897 (1) |
About this table
4 PharmGKB disease relationships for ITGB3 geneAbout this table
Genatlas disease: ITGB3 Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)
Human Gene Mutation Database: ITGB3
Genetic Association Database: ITGB3
Human Genome Epidemiology Navigator: ITGB3 (189 documents)
|
Medical News
for ITGB3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ITGB3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/809 PubMed articles for ITGB3 gene (see all 809
):- A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia. (PubMed id 12036875)3, 4, 6 Jallu V.... Kaplan C. (2002)
- Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. (PubMed id 15834589)1, 3, 6 Weiss L.A....Ober C. (2005)
- An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system. (PubMed id 1430225)1, 3, 4 Wang R....Newman P.J. (1992)
- A2 alelle of GpIIIa gene is a risk factor for stroke caused by large-vessel disease in males. (PubMed id 15178823)1, 3, 6 Slowik A....Szczudlik A. (2004)
- Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia. (PubMed id 10233432)1, 3, 4 Ruan J....Nurden A.T. (1999)
- A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa. (PubMed id 8132570)1, 3, 4 Santoso S.... Newman P.J. (1994)
- Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system. (PubMed id 7694683)1, 3, 4 Wang R.... Newman P.J. (1993)
- Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. (PubMed id 15817799)1, 3, 6 Weiss L.A....Ober C. (2005)
- GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. (PubMed id 2345548)1, 3, 4 Frachet P....Marguerie G. (1990)
- The genomic organization of platelet glycoprotein IIIa. (PubMed id 2341395)1, 3, 4 Zimrin A.B.... Poncz M. (1990)
|
Search for ITGB3
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ITGB3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ITGB3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ITGB3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| ATLAS Chromosomes in Cancer entry for ITGB3 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.genetests.org/query?gene=ITGB3 | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ITGB3 |
|
| | | About This Section
| --
| Services
for ITGB3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for ITGB3:
 | |
 | | | | |
 |
 |  |  | |
 | Antibodies & Assays for ITGB3 (Integrin B3) |
| | | | | Tocris compounds for ITGB3 |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
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