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Aliases for ITGB3 Gene

Aliases for ITGB3 Gene

  • Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61) 2 3
  • Platelet Membrane Glycoprotein IIIa 3 4
  • GPIIIa 3 4
  • GP3A 3 4
  • Platelet Glycoprotein IIIa 2
  • Integrin Beta-3 3
  • Antigen CD61) 6
  • CD61 Antigen 4
  • BDPLT16 3
  • BDPLT2 3
  • CD61 3
  • GT 3

External Ids for ITGB3 Gene

Previous Symbols for ITGB3 Gene

  • GP3A

Summaries for ITGB3 Gene

Entrez Gene Summary for ITGB3 Gene

  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGB3 Gene

ITGB3 (Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61)) is a Protein Coding gene. Diseases associated with ITGB3 include fetal and neonatal alloimmune thrombocytopenia and thrombasthenia of glanzmann and naegeli, itgb3-related. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include identical protein binding and cell adhesion molecule binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB3 Gene

  • Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.

Tocris Summary for ITGB3 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB3 Gene

Genomics for ITGB3 Gene

Genomic Location for ITGB3 Gene

Start:
47,253,842 bp from pter
End:
47,312,711 bp from pter
Size:
58,870 bases
Orientation:
Plus strand

Genomic View for ITGB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB3 Gene

Regulatory Elements for ITGB3 Gene

Proteins for ITGB3 Gene

  • Protein details for ITGB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05106-ITB3_HUMAN
    Recommended name:
    Integrin beta-3
    Protein Accession:
    P05106
    Secondary Accessions:
    • A0PJW2
    • D3DXJ8
    • O15495
    • Q12806
    • Q13413
    • Q14648
    • Q16499

    Protein attributes for ITGB3 Gene

    Size:
    788 amino acids
    Molecular mass:
    87058 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus) (By similarity). Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for ITGB3 Gene

    Alternative splice isoforms for ITGB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB3 Gene

Proteomics data for ITGB3 Gene at MOPED

Post-translational modifications for ITGB3 Gene

  • Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn125, Asn346, Asn397, Asn478, Asn585, and Asn680

Other Protein References for ITGB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGB3 Gene

Domains for ITGB3 Gene

Gene Families for ITGB3 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Graphical View of Domain Structure for InterPro Entry

P05106

UniProtKB/Swiss-Prot:

ITB3_HUMAN
Domain:
  • Contains 1 VWFA domain.:
    • P05106
Family:
  • Belongs to the integrin beta chain family.:
    • P05106
genes like me logo Genes that share domains with ITGB3: view

Function for ITGB3 Gene

Molecular function for ITGB3 Gene

GENATLAS Biochemistry: integrin,beta 3,platelet glycoprotein IIIa,Pen alloantigen,Sra alloantigen,involved in neonatal alloimmune thrombocytopenia and post-transfusion purpura,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,contributor,in association with PAI1 in susceptibility to myocardial infarction in Finnish population (see PAI1)
UniProtKB/Swiss-Prot Function: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.

Gene Ontology (GO) - Molecular Function for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IMP 24658351
GO:0002020 protease binding IDA 22505472
GO:0003756 protein disulfide isomerase activity IDA 12204115
GO:0004872 receptor activity IEA --
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
genes like me logo Genes that share ontologies with ITGB3: view
genes like me logo Genes that share phenotypes with ITGB3: view

Animal Models for ITGB3 Gene

MGI Knock Outs for ITGB3:

miRNA for ITGB3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGB3 Gene

Localization for ITGB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB3 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB3 Gene COMPARTMENTS Subcellular localization image for ITGB3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 3
cytoskeleton 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22027834
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2452834
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex IDA 15215180
genes like me logo Genes that share ontologies with ITGB3: view

Pathways for ITGB3 Gene

genes like me logo Genes that share pathways with ITGB3: view

Gene Ontology (GO) - Biological Process for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation TAS 19267251
GO:0001938 positive regulation of endothelial cell proliferation IMP 10022831
GO:0002576 platelet degranulation TAS --
GO:0006457 protein folding IDA 12204115
GO:0007044 cell-substrate junction assembly IEA --
genes like me logo Genes that share ontologies with ITGB3: view

Compounds for ITGB3 Gene

(5) Tocris Compounds for ITGB3 Gene

Compound Action Cas Number
A 286982 Potent inhibitor of the LFA-1/ICAM-1 interaction [280749-17-9]
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
Leukadherin 1 Allosteric activator of CD11b/CD18 [344897-95-6]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(4) Drugbank Compounds for ITGB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target antagonist
Antithymocyte globulin
  • rabbit ATG
target
Eptifibatide
  • Integrelin
188627-80-7 target
Tirofiban
144494-65-5 target antagonist

(30) Novoseek inferred chemical compound relationships for ITGB3 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 78 47
sele 61.7 2
adp 61 8
ristocetin 59.9 1
rhodostomin 50.6 2

(2) PharmGKB related drug/compound annotations for ITGB3 Gene

Drug/compound Annotation
aspirin CA
clopidogrel CA
genes like me logo Genes that share compounds with ITGB3: view

Transcripts for ITGB3 Gene

mRNA/cDNA for ITGB3 Gene

Unigene Clusters for ITGB3 Gene

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB3 Gene

No ASD Table

Relevant External Links for ITGB3 Gene

GeneLoc Exon Structure for
ITGB3
ECgene alternative splicing isoforms for
ITGB3

Expression for ITGB3 Gene

mRNA expression in normal human tissues for ITGB3 Gene

mRNA differential expression in normal tissues according to GTEx for ITGB3 Gene

This gene is overexpressed in Artery - Aorta (5.6), Artery - Tibial (4.8), Artery - Coronary (4.1), and Colon - Sigmoid (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ITGB3 Gene

SOURCE GeneReport for Unigene cluster for ITGB3 Gene Hs.218040

mRNA Expression by UniProt/SwissProt for ITGB3 Gene

P05106-ITB3_HUMAN
Tissue specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis
genes like me logo Genes that share expressions with ITGB3: view

Orthologs for ITGB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB3 35
  • 99.53 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia INTB3 36
  • 96 (a)
OneToMany
ITGB3 35
  • 90.63 (n)
  • 95.4 (a)
dog
(Canis familiaris)
Mammalia GPIIIA 36
  • 94 (a)
OneToMany
ITGB3 35
  • 91.36 (n)
  • 95.53 (a)
mouse
(Mus musculus)
Mammalia Itgb3 35
  • 86.62 (n)
  • 90.72 (a)
Itgb3 16
Itgb3 36
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Itgb3 35
  • 87.04 (n)
  • 90.22 (a)
chicken
(Gallus gallus)
Aves ITGB3 35
  • 79.07 (n)
  • 83.25 (a)
ITGB3 36
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397699 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itgb3 35
  • 70.4 (n)
  • 76.15 (a)
zebrafish
(Danio rerio)
Actinopterygii itgb3a 36
  • 60 (a)
ManyToMany
itgb3b 35
  • 68.82 (n)
  • 70.98 (a)
itgb3b 36
  • 68 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bgrInt-ngr 37
  • 30 (a)
mys 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 37
  • 38 (a)
Species with no ortholog for ITGB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB3 Gene

ENSEMBL:
Gene Tree for ITGB3 (if available)
TreeFam:
Gene Tree for ITGB3 (if available)

Paralogs for ITGB3 Gene

genes like me logo Genes that share paralogs with ITGB3: view

Variants for ITGB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB3 Gene

P05106-ITB3_HUMAN
Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP)

Sequence variations from dbSNP and Humsavar for ITGB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4634 -- 47,292,423(+) CCCCG(A/G)GAGGG synonymous-codon, reference
rs4642 -- 47,292,411(+) GACGA(A/G)TGCAG reference, synonymous-codon
rs5917 Pathogenic, - 47,284,587(+) GATGC(A/G)AAAGC missense, reference
rs5918 Pathogenic, - 47,283,364(+) GCCTC(C/T)GGGCT missense, reference
rs5919 -- 47,287,174(+) CAGCC(C/T)AATGA synonymous-codon, reference

Relevant External Links for ITGB3 Gene

HapMap Linkage Disequilibrium report
ITGB3
Human Gene Mutation Database (HGMD)
ITGB3
Locus Specific Mutation Databases (LSDB)
ITGB3

No data available for Structural Variations from Database of Genomic Variants (DGV) for ITGB3 Gene

Disorders for ITGB3 Gene

(3) OMIM Diseases for ITGB3 Gene (173470)

UniProtKB/Swiss-Prot

ITB3_HUMAN
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269 PubMed:10233432, ECO:0000269 PubMed:11588040, ECO:0000269 PubMed:11897046, ECO:0000269 PubMed:12083483, ECO:0000269 PubMed:12353082, ECO:0000269 PubMed:1371279, ECO:0000269 PubMed:1438206, ECO:0000269 PubMed:15583747, ECO:0000269 PubMed:15634267, ECO:0000269 PubMed:15748237, ECO:0000269 PubMed:1602006, ECO:0000269 PubMed:20020534, ECO:0000269 PubMed:2392682, ECO:0000269 PubMed:8781422, ECO:0000269 PubMed:9215749, ECO:0000269 PubMed:9376589, ECO:0000269 PubMed:9684783, ECO:0000269 PubMed:9790984}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269 PubMed:18065693}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(46) Novoseek inferred disease relationships for ITGB3 Gene

Disease -log(P) Hits PubMed IDs
glanzmann thrombasthenia 93.7 24
coagulopathy 60.8 3
thrombocytopenia 59.2 12
erythroleukemia 55.6 2
coronary thrombosis 41.8 3

Genatlas disease for ITGB3 Gene

Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

Relevant External Links for ITGB3

Genetic Association Database (GAD)
ITGB3
Human Genome Epidemiology (HuGE) Navigator
ITGB3
genes like me logo Genes that share disorders with ITGB3: view

Publications for ITGB3 Gene

  1. A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation. (PMID: 1602006) Lanza F. … Cazenave J.-P. (J. Clin. Invest. 1992) 3 4 23
  2. An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system. (PMID: 1430225) Wang R. … Newman P.J. (J. Clin. Invest. 1992) 3 4 23
  3. Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. (PMID: 1438206) Chen Y.-P. … Rosa J.-P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  4. Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family. (PMID: 2001252) Calvete J.J. … Gonzalez-Rodriguez J. (Biochem. J. 1991) 3 4 23
  5. The genomic organization of platelet glycoprotein IIIa. (PMID: 2341395) Zimrin A.B. … Poncz M. (J. Biol. Chem. 1990) 3 4 23

Products for ITGB3 Gene

  • Addgene plasmids for ITGB3

Sources for ITGB3 Gene

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