Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGB2 Gene

protein-coding GIFtS: 74
GCID: GC21M046305

integrin, beta 2 (complement component 3 receptor 3 and...

(Previous names: integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated...)
(Previous symbols: CD18, MFI7)

Explore 145 diseases affiliated with
ITGB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit)¹ ²		Cell Surface Adhesion Glycoprotein (LFA-1,CR3,P150,959 Beta Subunit Precursor)11
CD18¹ ² ³ ⁵		MF17²
MFI7¹ ² ³		Cell Surface Adhesion Glycoprotein LFA-1/CR3/P150,959 Beta Subunit Precursor)²
LFA-1¹ ²		Complement Receptor C3 Beta-Subunit²
MAC-1¹ ²		Integrin Beta Chain, Beta 2²
Cell Surface Adhesion Glycoproteins LFA-1/CR3/P150,95 Subunit Beta² ³		Integrin Beta-2²
Complement Receptor C3 Subunit Beta² ³		Leukocyte Cell Adhesion Molecule CD18²
LAD² ⁵		Leukocyte-Associated Antigens CD18/11A, CD18/11B, CD18/11C²
LCAMB² ⁵		CD18 Antigen³
Integrin, Beta 2 (Antigen CD18 (P95), Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1 (Mac-1) Beta Subunit)¹

External Ids:	HGNC: 6155¹	Entrez Gene: 3689²	Ensembl: ENSG00000160255⁷	OMIM: 600065⁵	UniProtKB: P05107³

Export aliases for ITGB2 gene to outside databases

Previous GC identifers: GC21M042815 GC21M045162 GC21M045130 GC21M031679

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGB2:

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface

proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain

may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L

chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known

to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of

leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified

for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITB2_HUMAN, P05107

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and

alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin

alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2

peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2

is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated

activation

Gene Wiki entry for ITGB2 (CD18)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGB2 gene promoter:
STAT1 AP-1 p300 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): ITGB2 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

ITGB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB2 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M046305:	GeneLoc	Nature:405,311-319
Start:	46,305,868 bp from pter	31,815,297 bp from centromere
End:	46,351,904 bp from pter	31,850,215 bp from centromere
Size:	46,037 bases	34,919 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	M15395
genomic clones:	BAC-7B7 Q15C24

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITB2_HUMAN, P05107 (See protein sequence)

Recommended Name: Integrin beta-2 precursor

Size: 769 amino acids; 84782 Da

Subunit: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or

alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAD96225.1; Type=Erroneous initiation;

6/10 PDB 3D structures from and Proteopedia for ITGB2 (see all 10):

1JX3 (3D)

1L3Y (3D)

1YUK (3D)

2JF1 (3D)

2P26 (3D)

2P28 (3D)

Secondary accessions: B3KTS8 D3DSM1 Q16418 Q53HS5 Q9UD72

Explore the universe of human proteins at neXtProt for ITGB2: NX_P05107

Post-translational modifications:

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758

(but not on Ser-756) allows interaction with 14-3-3 proteins¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05107

ITGB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000202.2 NP_001120963.1

ENSEMBL proteins:

ENSP00000380950 ENSP00000380955 ENSP00000380952 ENSP00000347279 ENSP00000380948

ENSP00000427732 ENSP00000317697 ENSP00000428503 ENSP00000428979 ENSP00000428413

ENSP00000428125 ENSP00000428434 ENSP00000430901 ENSP00000428870 ENSP00000380944

ENSP00000429683 ENSP00000303242

Reactome Protein details: P05107
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ITGB2 (Integrin beta 2/CD18)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): ITGB2 OriGene Custom Protein Services for ITGB2
	GenScript Custom Purified and Recombinant Proteins Services for ITGB2
	Novus Biologicals ITGB2 Proteins Novus Biologicals ITGB2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	NAS	12885943

ITGB2 for ontologies About GeneDecksing

ITGB2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB2
	R&D Systems Antibodies for ITGB2 (Integrin beta 2/CD18)
	OriGene Antibodies (see all 2): ITGB2 OriGene Custom Antibody Services for ITGB2
	GenScript Custom Superior Antibodies Services for ITGB2
	Novus Biologicals ITGB2 Antibodies
	Abcam antibodies for ITGB2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ITGB2

Assay Products for ITGB2:

	EMD Millipore Kits and Assays for the Analysis of ITGB2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for ITGB2 (Integrin beta 2/CD18)
	GenScript Custom Assay Services for ITGB2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGB2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR003659 Plexin-like

IPR002369 Integrin_bsu_N

IPR012896 Integrin_bsu_tail

IPR016201 Plexin-like_fold

IPR015439 Integrin_bsu-2

Graphical View of Domain Structure for InterPro Entry P05107

ProtoNet protein and cluster: P05107

3 Blocks protein families:

IPB001169 Integrin beta

IPB002035 Von Willebrand factor type A domain signature

IPB002369 Integrin beta subunit signature

UniProtKB/Swiss-Prot: ITB2_HUMAN, P05107

Similarity: Belongs to the integrin beta chain family

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITB2_HUMAN, P05107

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and

alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin

alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2

peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2

is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated

activation

Genatlas biochemistry entry for ITGB2:

integrin,beta 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,expressed in leukocytes,common component of LFA-1,Mac-1 and p150,95 antigens

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ITGB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGB2
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB2 (see all 7) OriGene shRNA RFP: ITGB2 OriGene siRNA: ITGB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ITGB2 (NM_000211)
		Sino Biological Human cDNA Clone for ITGB2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGB2
		Search LifeMap BioReagents cell lines for ITGB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IPI	16831868
GO:0004872	receptor activity	IEA	--
GO:0005102	receptor binding	IEA	--
GO:0019901	protein kinase binding	IPI	12885943
GO:0046872	metal ion binding	IEA	--

ITGB2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ITGB2:

Decreased Salmonella enterica

Animal Models:
Mouse knock-outs for ITGB2: Itgb2^tm1Bay Itgb2^tm2Bay
11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Itgb2):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	immune system
integument	mortality/aging	normal	pigmentation	skeleton
vision/eye

ITGB2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/46 super-pathways (see all 46) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Immune response_Alternative complement pathway

	Immune response Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response_Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for ITGB2

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response Lectin Induced complement pathway
	Cell adhesion Integrin inside-out signaling

5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGB2 (see all 35)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

5/6 GeneGo (Thomson Reuters) Pathways for ITGB2 (see all 6)

	Immune response Alternative complement pathway
	Cell adhesion Integrin inside-out signaling
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response Classical complement pathway
	Immune response Role of integrins in NK cells cytotoxicity

5/7 BioSystems Pathways for ITGB2 (see all 7)

	Integrin-mediated cell adhesion
	Focal Adhesion
	IL-5 Signaling Pathway
	HIF-1-alpha transcription factor network
	amb2 Integrin signaling

5/10 Reactome Pathways for ITGB2 (see all 10)

	Hemostasis
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Toll Like Receptor 4 (TLR4) Cascade
	Toll-Like Receptors Cascades

5/13 Kegg Pathways (Kegg details for ITGB2) (see all 13):

	Phagosome
	Cell adhesion molecules (CAMs)
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

ITGB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/142 Interacting proteins for ITGB2 (P05107^{2, 3} ENSP00000303242⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 142)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RANBP9	Q96S59²^,³, ENSP00000011619⁴	MINT-50055 MINT-50069 MINT-50052 MINT-50054 I2D: score=4 STRING: ENSP00000011619
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-7226083 MINT-7226063 MINT-7226073 MINT-7226098 I2D: score=1 STRING: ENSP00000361423
RDX	P35241²^,³, ENSP00000342830⁴	MINT-4652127 MINT-4652107 I2D: score=2 STRING: ENSP00000342830
CYTH1	Q15438²^,³, ENSP00000354398⁴	MINT-4652150 I2D: score=5 STRING: ENSP00000354398
VAV1	P15498²^,³, ENSP00000302269⁴	MINT-7226634 I2D: score=1 STRING: ENSP00000302269

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	NAS	12885943
GO:0006954	inflammatory response	NAS	12885943
GO:0007155	cell adhesion	TAS	1694220
GO:0007159	leukocyte cell-cell adhesion	IDA	12885943
GO:0007160	cell-matrix adhesion	IEA	--

ITGB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGB2

1 HMDB Compound for ITGB2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

1 DrugBank Compound for ITGB2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Simvastatin	Simvastatin [Usan:Ban:Inn] (see all 4)	79902-63-9	target	other	15936988 16828882 15041742 17289088

10/114 Novoseek chemical compound relationships for ITGB2 gene (see all 114) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp	75.1	44	7525325 (5), 16249234 (4), 8100744 (3), 8104223 (2) (see all 23)
lfa703	70.8	2	15161667 (1)
n-formylmethionyl-leucylphenylalanine	62.9	16	7525325 (5), 9142928 (1), 10625005 (1), 15454120 (1) (see all 7)
phorbol	59.4	5	1850304 (1), 10779523 (1), 7622590 (1), 16099426 (1) (see all 5)
slex	58.8	11	8547121 (1), 12580864 (1), 7487990 (1), 8740264 (1) (see all 10)
dexamethasone 21-isonicotinate	56.2	1	15099507 (1)
fibrinogen	50.3	45	12665127 (4), 10845911 (4), 10510057 (3), 1309032 (2) (see all 22)
cytochalasin b	48.3	1	8914597 (1)
cuprophan	48	7	8455364 (2), 7503138 (1), 8770974 (1), 11549901 (1)
kininogen	43.3	5	8034694 (1), 16902163 (1), 10845911 (1), 10515875 (1)

Search CenterWatch for drugs/clinical trials and news about ITGB2 / ITB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGB2 gene (2 alternative transcripts):

NM_000211.3 NM_001127491.1

Unigene Cluster for ITGB2:

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Hs.375957 [show with all ESTs]

Unigene Representative Sequence: NM_000211

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000475170 ENST00000397852(uc002zgd.2) ENST00000397857 ENST00000397854

ENST00000498666 ENST00000355153(uc002zgg.2) ENST00000397850(uc002zgf.3 uc011afl.1 uc010gpw.2)

ENST00000523323 ENST00000479202 ENST00000320216 ENST00000521987 ENST00000523663

ENST00000522931 ENST00000517563 ENST00000522688 ENST00000520389 ENST00000524251

ENST00000517819

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ITGB2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGB2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGB2
		SwitchGear 3'UTR luciferase reporter plasmid: ITGB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB2 (see all 7) OriGene shRNA RFP: ITGB2 OriGene siRNA: ITGB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ITGB2 (NM_000211)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB2

Additional cDNA sequence:

AK095992.1 AK097864.1 AK128344.1 AK222505.1 AK303488.1 BC005861.2 BC021077.1 L78790.1

M15395.1 Y00057.1

24/28 DOTS entries (see all 28):

DT.100649228 DT.100649224 DT.95365956 DT.100649223 DT.91754605 DT.100844990 DT.101984355 DT.415667

DT.97805072 DT.95146677 DT.121142911 DT.415668 DT.95363832 DT.99930189 DT.121142914 DT.95183164

DT.100037383 DT.121142820 DT.121142822 DT.121142837 DT.121142870 DT.121142874 DT.121142888 DT.40117396

24/268 AceView cDNA sequences (see all 268):

BQ053186 CD514549 BU618015 AW027309 AU159090 BG054693 BU615774 AI133046

BM855207 BQ029613 BU152692 AL552968 AA149070 BX956167 AU279404 CR621205

BX107224 BX461693 AI354476 BQ723767 CA388988 AA603700 BF899362 AA502353

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB2 (see all 22) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11	^
SP1:																			-		-		-				-		-		-						-		-		-
SP2:					-		-		-		-		-		-		-		-		-		-				-		-		-						-		-		-
SP3:																			-		-		-				-		-		-						-		-		-		-
SP4:																			-		-		-				-		-		-						-		-		-										-
SP5:																											-		-		-						-		-		-

ExUns:	12a	·	12b	·	12c	·	12d	^	13a	·	13b	·	13c	·	13d	·	13e	^	14a	·	14b	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·	23c
SP1:									-																		-										-
SP2:									-																		-										-
SP3:									-																		-										-
SP4:	-		-		-		-		-																		-										-
SP5:									-																		-										-

ECgene alternative splicing isoforms for ITGB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACTTGAG

About this image

ITGB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesenchymal stem cells (Stepwise differentia...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITGB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGB2

SOURCE GeneReport for Unigene cluster: Hs.375957

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGB2 (see all 11):

Extracellular Matrix & Adhesion Molecules in human mouse rat

Multiple Sclerosis in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGB2 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGB2¹	integrin, beta 2 (complement component 3 receptor 3 more	67.55(n) 65.11(a)		396181 NM_205251.1 NP_990582.1
lizard (Anolis carolinensis)	Reptilia	ITGB2⁶	--	60(a)	1 ↔ 1	GL343645.1(224805-256392)
African clawed frog (Xenopus laevis)	Amphibia	MGC69035²	hypothetical protein MGC69035	72.67(n)		BC059319.1
zebrafish (Danio rerio)	Actinopterygii	itgb2¹	integrin, beta 2 (complement component 3 receptor 3 more	56.03(n) 51.73(a)		557797 XM_680920.3 XP_686012.3
fruit fly (Drosophila melanogaster)	Insecta	mys³	central nervous system development calcium-dependent more	39(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	pat-3³	beta integrin	38(a)		III(3981133-3985933) --

ENSEMBL Gene Tree for ITGB2 (if available)
TreeFam Gene Tree for ITGB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGB2 gene

ITGB4² ITGB1² ENSG00000259753² ITGB7² ITGB3² ITGBL1² ITGB8² ITGB6²

ITGB5²

7 SIMAP similar genes for ITGB2 using alignment to 16 protein entries: ITB2_HUMAN (see all proteins):

ITGB7 ITGB5 ITGB3 ITGB1 ITGB6 ITGB8

ITGB4

ITGB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137852615^1,2	C	pathogenic	46323397(-)	`CCATCA/G/TACCTG`	6	N D Y	mis¹		0	--	--	--	--
rs113221535^1,2	C,	--	46305400(+)	`ACTGCC/TGGAGG`	2	--	ds500¹		0	--	--	--	--
rs113421921^1,2	C,	--	46305438(+)	`GTAGAC/TGGCTG`	2	--	ds500¹		1		NA	2
rs28373949^1,2	C	--	46305439(+)	`TAGACA/G/TGCTGG`	2	--	ds500¹		1		NA	2
rs144005642^1,2		--	46305490(+)	`GGAGGA/GGAGGT`	2	--	ds500¹		0	--	--	--	--
rs112395546^1,2	C,	--	46305520(+)	`GTGTAG/AAGCTG`	2	--	ds500¹		2		WA	120
rs28568877^1,2	C,F,	--	46305627(+)	`TCCGCT/CGCAGG`	2	--	ds500¹		11		NA WA CSA EA	372
rs183800869^1,2		--	46305662(+)	`GTTTAC/TGGAAA`	2	--	ds500¹		0	--	--	--	--
rs148250032^1,2		--	46305677(+)	`CCTAGA/GATTTG`	2	--	ds500¹		0	--	--	--	--
rs187961139^1,2		--	46305806(+)	`CAGGAC/TAGGGC`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ITGB2 (46305868 - 46351904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ITGB2
3 CNVs: 53434 50786 10604
1 Indel: 26991
Human Gene Mutation Database (HGMD): ITGB2

Locus Specific Mutation Databases (LSDB): ITGB2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGB2

DNA2.0 Custom Variant and Variant Library Synthesis for ITGB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGB2 for disorders           About GeneDecksing

OMIM gene information: 600065
OMIM disorders: 116920
UniProtKB/Swiss-Prot: ITB2_HUMAN, P05107

Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:116920]. LAD1 patients have

recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions

20/145 diseases for ITGB2 (see all 145): About MalaCards

erythema elevatum diutinum leukocyte adhesion deficiency type 1 leukocyte-adhesion deficiency syndrome b-cell non-hodgkin lymphoma

lymph node cancer non-hodgkin lymphoma chronic venous leg ulcers age related macular degeneration

neonatal alloimmune thrombocytopenia wegener's granulomatosis mycosis fungoides pyoderma gangrenosum

lichen planus plasmodium falciparum malaria pre-eclampsia lepromatous leprosy

acute myocardial infarction type 2 diabetes mellitus inflammatory bowel disease myocardial infarction

1 disease from the University of Copenhagen DISEASES database for ITGB2:

Leukocyte adhesion deficiency

10/95 Novoseek disease relationships for ITGB2 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukocyte adhesion deficiency, type i	74.2	4	17675274 (1), 18216298 (1), 17651379 (1)
leukocyte adhesion deficiency syndrome	68.6	3	7685776 (1), 11753075 (1), 10419878 (1)
inflammation	62.4	42	11857637 (3), 8083366 (1), 8995280 (1), 10223354 (1) (see all 36)
necrosis	50.6	33	8656013 (2), 8094958 (2), 7689934 (2), 1709380 (1) (see all 29)
psoriasis	32.7	8	1401271 (2), 18521187 (2), 17596165 (1), 10228626 (1) (see all 6)
mycosis fungoides	32.2	2	1281618 (1), 7539248 (1)
immunodeficiency	30.5	17	7847878 (1), 8656013 (1), 9990374 (1), 17675274 (1) (see all 14)
asthma allergic	30.1	1	10391069 (1)
rheumatoid arthritis	30	8	8394794 (1), 7481076 (1), 8853226 (1), 8912515 (1) (see all 7)
lymphocytic leukemia chronic b-cell	28.1	4	7915162 (2), 7690438 (1), 1586717 (1)

Genatlas disease: ITGB2

bacterial,recurrent,severe life-threatening infections,chronic neutrophilia,and impaired wound healing associated with

gingivoperiodontitis and lack of pus formation,leukocyte adhesion deficiency

Genetic Association Database (GAD): ITGB2
Human Genome Epidemiology (HuGE) Navigator: ITGB2 (35 documents)

Export disorders for ITGB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGB2 gene, integrated from 9 sources (see all 1269):
(articles sorted by number of sources associating them with ITGB2)

Utopia: connect your pdf to the dynamic
world of online information

A prospective evaluation of the CD14 and CD18 gene polymorphisms and risk of stroke. (PubMed id 11935032)^{1, 4, 9} Zee R.Y....Ridker P.M. (2002)
A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1. (PubMed id 9884339)^{1, 2, 9} Hogg N....Klein N. (1999)
Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. (PubMed id 1346613)^{1, 2, 9} Nelson C.... Arnaout M.A. (1992)
Molecular basis for a severe case of leukocyte adhesion deficiency. (PubMed id 1352501)^{1, 2, 9} Corbi A....Sanchez-Madrid F. (1992)
A novel point mutation in CD18 causing leukocyte adhe sion deficiency in a Chinese patient. (PubMed id 20529581)^{1, 2} Li L....Chen T.X. (2010)
Characterization of 11 new cases of leukocyte adhesio n deficiency type 1 with seven novel mutations in the ITGB2 gene. (PubMed id 20549317)^{1, 2} Parvaneh N....Aghamohammadi A. (2010)
Structure of an integrin with an alphaI domain, compl ement receptor type 4. (PubMed id 20033057)^{1, 2} Xie C....Springer T.A. (2010)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3689	HGNC: 6155	AceView: ITGB2	Ensembl:ENSG00000160255	euGenes: HUgn3689
ECgene: ITGB2	Kegg: 3689	H-InvDB: ITGB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGB2	Genetics and Cytogenetics in Oncology and Haematology
ITGB2base	http://bioinf.uta.fi/ITGB2base/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGB2

Intellectual Property for ITGB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ITGB2 gene:
Search GeneIP for patents involving ITGB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB2
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Kits and Assays for the Analysis of ITGB2

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for ITGB2 (Integrin beta 2/CD18)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for ITGB2 (Integrin beta 2/CD18)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for ITGB2 (Integrin beta 2/CD18)

	OriGene Antibodies for ITGB2		OriGene shRNA RFP for ITGB2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGB2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGB2
	OriGene Protein Over-expression Lysate for ITGB2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ITGB2		OriGene 3'-UTR Clone for ITGB2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGB2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ITGB2		OriGene Custom Protein Services for ITGB2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGB2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGB2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGB2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGB2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGB2

	GenScript Custom Purified and Recombinant Proteins Services for ITGB2		GenScript cDNA clones with any tag delivered in your preferred vector for ITGB2
	GenScript Custom Assay Services for ITGB2		GenScript Custom Superior Antibodies Services for ITGB2
	GenScript Custom overexpressing Cell Line Services for ITGB2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ITGB2 promoter
	Search Chromatin IP Primers for ITGB2
	RT² qPCR Primer Assay in human, mouse, rat ITGB2
	GNC Network for ITGB2
	SABiosciences PCR Arrays including human, mouse, rat ITGB2

Search Tocris compounds for ITGB2

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for ITGB2
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ITGB2 antibodies
	ITGB2 proteins
	ITGB2 lysates

	Antibodies for ITGB2
	See all of Abcam's Antibodies, Kits and Proteins for ITGB2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for ITGB2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB2

	SwitchGear 3'UTR luciferase reporter plasmids for ITGB2
	SwitchGear Promoter luciferase reporter plasmids for ITGB2

ThermoFisher Antibody for ITGB2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ITGB2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ITGB2 Gene

integrin, beta 2 (complement component 3 receptor 3 and...

Aliases
for ITGB2 gene

Summaries
for ITGB2 gene

Genomic Views
for ITGB2 gene

Proteins
for ITGB2 gene

Protein Domains /
Families
for ITGB2 gene

Function
for ITGB2 gene

Pathways & Interactions
for ITGB2 gene

Drugs & Compounds
for ITGB2 gene

Transcripts
for ITGB2 gene

Expression
for ITGB2 gene

Orthologs
for ITGB2 gene

Paralogs
for ITGB2 gene

Genomic Variants
for ITGB2 gene

Disorders / Diseases
for ITGB2 gene

Publications
for ITGB2 gene

External Searches for ITGB2 gene

Genome Databases showing ITGB2 gene

Other Databases showing ITGB2 gene

Specialized Databases showing ITGB2 gene

Intellectual Property
for ITGB2 gene

Products
for ITGB2 gene

View Random Gene

ITGB2 (Gene Symbol)
Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit)
CD18
MFI7
LFA-1
MAC-1
Cell Surface Adhesion Glycoproteins LFA-1/CR3/P150,95 Subunit Beta
Complement Receptor C3 Subunit Beta
LAD
LCAMB
Integrin, Beta 2 (Antigen CD18 (P95), Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1 (Mac-1) Beta Subunit)
Cell Surface Adhesion Glycoprotein (LFA-1,CR3,P150,959 Beta Subunit Precursor)
MF17
Cell Surface Adhesion Glycoprotein LFA-1/CR3/P150,959 Beta Subunit Precursor)
Complement Receptor C3 Beta-Subunit
Integrin Beta Chain, Beta 2
Integrin Beta-2
Leukocyte Cell Adhesion Molecule CD18
Leukocyte-Associated Antigens CD18/11A, CD18/11B, CD18/11C
CD18 Antigen

Leg Ulcer
Measles
Leukocyte Adhesion Deficiency Syndrome
sepsis
Acute myocardial infarction
Lymphoma T-Cell
Allergic Reaction
Colitis Ulcerative
Paraparesis Tropical Spastic
Ischemia
Skin Diseases
Respiratory Distress Syndrome
Breast Cancer
Edema
Adenocarcinoma
Asthma
Mycosis Fungoides
cell damage
Cancer
Urticaria
Lymphoma
Splenomegaly
RENAL DISEASE
Bronchoalveolar Lavage Fluid
Multiple Sclerosis
Inflammation
Malaria Falciparum
Proteinuria
Tuberculosis
Leukemia Hairy Cell
immunodeficiency
Psoriasis
MYELOMA
Rheumatoid Arthritis
Periodontitis Juvenile
Tumors
Thrombosis
Metastasis
LEUKOCYTE ADHESION DEFICIENCY, TYPE I
Necrosis
Lymphoblastic Leukemia Acute
Autoimmunity
Asthma allergic
Lichen Planus
virus infection
Preeclampsia
Gastric Cancer
Myeloid Leukemia
Autoimmune Diseases
Dermatitis
Vasculitis
Leukemia Lymphocytic Chronic
Hyperplasia
Venous Thrombosis
Leukocytosis
Bacterial Infections
Idiopathic Membranous Nephropathy
Carcinoma
INFARCT
Osteoarthritis
ACUTE LEUKEMIA
Myeloid Leukemia Chronic
Leukemia
Alzheimers Disease
Diabetes Mellitus
Agranulocytosis
Lymphopenia
Inflammatory Bowel Diseases
INFECTION FUNGAL
Coronary Artery Disease
Response Acute Phase
Lymphoma B-Cell
HIV Infections
Eosinophilia
Lymphocytic Leukemia Chronic B-Cell
autoimmune thyroid disease
Carcinoma Squamous Cell
Lung diseases
SKIN LESION
Atrophy
Leukemia Promyelocytic Acute
URTICARIA ACUTE
STROKE
Wegeners Granulomatosis
Graves Disease
Chromosomal Aberrations
Gastrointestinal carcinoma
Lupus Nephritis
Hashimotos Thyroiditis
Glomerulonephritis
Peritonitis
Sclerosis Systemic
Synovitis
Lupus Erythematosus Systemic
Arthritis

Advanced Search

Export list of displayed genes

ITGB2 Gene

integrin, beta 2 (complement component 3 receptor 3 and...

Aliasesfor ITGB2 gene

Summariesfor ITGB2 gene

Genomic Viewsfor ITGB2 gene

Proteinsfor ITGB2 gene

Protein Domains /Familiesfor ITGB2 gene

Functionfor ITGB2 gene

Pathways & Interactionsfor ITGB2 gene

Drugs & Compoundsfor ITGB2 gene

Transcriptsfor ITGB2 gene

Expression for ITGB2 gene

Orthologsfor ITGB2 gene

Paralogsfor ITGB2 gene

Genomic Variantsfor ITGB2 gene

Disorders / Diseasesfor ITGB2 gene

Publicationsfor ITGB2 gene

External Searches for ITGB2 gene

Genome Databases showing ITGB2 gene

Other Databases showing ITGB2 gene

Specialized Databases showing ITGB2 gene

Intellectual Propertyfor ITGB2 gene

Productsfor ITGB2 gene

View Random Gene

Aliases
for ITGB2 gene

Summaries
for ITGB2 gene

Genomic Views
for ITGB2 gene

Proteins
for ITGB2 gene

Protein Domains /
Families
for ITGB2 gene

Function
for ITGB2 gene

Pathways & Interactions
for ITGB2 gene

Drugs & Compounds
for ITGB2 gene

Transcripts
for ITGB2 gene

Expression
for ITGB2 gene

Orthologs
for ITGB2 gene

Paralogs
for ITGB2 gene

Genomic Variants
for ITGB2 gene

Disorders / Diseases
for ITGB2 gene

Publications
for ITGB2 gene

Intellectual Property
for ITGB2 gene

Products
for ITGB2 gene