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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGB1BP1 Gene

protein-coding GIFtS: 54
GCID: GC02M009496

integrin beta 1 binding protein 1

Explore 7 diseases affiliated with
ITGB1BP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin Beta 1 Binding Protein 1¹ ²		Integrin Cytoplasmic Domain-Associated Protein 1² ³
ICAP1¹ ² ³ ⁵		ICAP-1² ³
ICAP1A¹ ² ⁵		Bodenin¹
ICAP1B¹ ² ⁵		Integrin Beta-1-Binding Protein 1²
ICAP-1A¹ ²		Integrin Cytoplasmic Domain-Associated Protein 1-Alpha²
ICAP-1B¹ ²		Integrin Cytoplasmic Domain-Associated Protein 1-Beta²
ICAP-1alpha¹ ²

External Ids:	HGNC: 23927¹	Entrez Gene: 9270²	Ensembl: ENSG00000119185⁷	OMIM: 607153⁵	UniProtKB: O14713³

Export aliases for ITGB1BP1 gene to outside databases

Previous GC identifers: GC02M009567 GC02M009391

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGB1BP1:

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the

beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two

isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not

interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its

phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during

integrin-dependent cell adhesion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITBP1_HUMAN, O14713

Function: Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of

integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of

ITGB1 to focal contacts during integrin-dependent cell adhesion

Gene Wiki entry for ITGB1BP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005334.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGB1BP1 gene promoter:
p53 MAZR Egr-1 Olf-1 CUTL1 Nkx2-5 HNF-1A HNF-1 Pax-4a En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGB1BP1 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGB1BP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB1BP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.2 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.2

ITGB1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB1BP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M009496: view genomic region (about GC identifiers)

Start:	9,543,604 bp from pter	End:	9,563,676 bp from pter
Size:	20,073 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITBP1_HUMAN, O14713 (See protein sequence)

Recommended Name: Integrin beta-1-binding protein 1

Size: 200 amino acids; 21782 Da

Subunit: Interacts with KRIT1 and ITGB1; KRIT1 and ITGB1 compete for the same binding site. Isoform 2 does not interact

with ITGB1

Subcellular location: Cytoplasm

3 PDB 3D structures from and Proteopedia for ITGB1BP1:

1K11 (3D)

4DX8 (3D)

4DX9 (3D)

Secondary accessions: D6W4Y9 O14714 Q53RS0

Alternative splicing: 2 isoforms: O14713-1 O14713-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ITGB1BP1: NX_O14713

Post-translational modifications:

Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation

is regulated by integrin-dependent cell-matrix interaction¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14713

ITGB1BP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004754.1 NP_071729.1

ENSEMBL proteins:

ENSP00000353850 ENSP00000238091 ENSP00000347504 ENSP00000433814 ENSP00000419452

ENSP00000352743 ENSP00000419524 ENSP00000389704 ENSP00000420770 ENSP00000417940

ENSP00000419814 ENSP00000418526 ENSP00000417850 ENSP00000418947

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	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	11919189
GO:0005829	cytosol	IDA	11919189
GO:0016020	membrane	NAS	9281591
GO:0030027	lamellipodium	IDA	11919189

ITGB1BP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGB1BP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR006020 PTyr_interaction_dom

IPR019517 Integrin-bd_ICAP-1

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry O14713

ProtoNet protein and cluster: O14713

1 Blocks protein family: IPB006020 Phosphotyrosine interaction domain

UniProtKB/Swiss-Prot: ITBP1_HUMAN, O14713

Similarity: Contains 1 PID domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITBP1_HUMAN, O14713

Function: Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of

integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of

ITGB1 to focal contacts during integrin-dependent cell adhesion

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		hsa-miR-33a* hsa-miR-4307 hsa-miR-409-3p hsa-miR-1208 hsa-miR-642b
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1BP1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11919189

ITGB1BP1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ITGB1BP1:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

PARP inhibitor sensitization

Animal Models:
Mouse knock-out Itgb1bp1^tm1Ref for ITGB1BP1
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itgb1bp1):

craniofacial	growth/size	mortality/aging	normal	skeleton
vision/eye

ITGB1BP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ITGB1BP1

Cell adhesion Integrin inside-out signaling

1 GeneGo (Thomson Reuters) Pathway for ITGB1BP1

Cell adhesion Integrin inside-out signaling

ITGB1BP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGB1BP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/13 Interacting proteins for ITGB1BP1 (O14713^{1, 2, 3} ENSP00000347504⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME2	P22392¹^,³, ENSP00000365572⁴	EBI-2127367,EBI-713693 I2D: score=2 STRING: ENSP00000365572
FAF1	Q9UNN5²^,³, ENSP00000379457⁴	MINT-8258782 I2D: score=2 STRING: ENSP00000379457
NME1-NME2	P22392¹^,³	EBI-2127367,EBI-713693 I2D: score=2
EEF1A1	P68104²^,³	MINT-8258767 I2D: score=2
KRIT1	O00522³, ENSP00000344668⁴	I2D: score=7 STRING: ENSP00000344668

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007160	cell-matrix adhesion	IDA	9281591
GO:0007229	integrin-mediated signaling pathway	--	--
GO:0007243	intracellular protein kinase cascade	TAS	9813144
GO:0016477	cell migration	TAS	11919189

ITGB1BP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGB1BP1
Search CenterWatch for drugs/clinical trials and news about ITGB1BP1 / ITBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGB1BP1 gene (2 alternative transcripts):

NM_004763.3 NM_022334.3

Unigene Cluster for ITGB1BP1:

Integrin beta 1 binding protein 1

Hs.467662 [show with all ESTs]

Unigene Representative Sequence: AK093179

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000360635 ENST00000238091 ENST00000355346(uc002qzj.3 uc002qzk.3 uc010yiy.2 uc002qzm.3)

ENST00000483795(uc002qzl.3) ENST00000490426 ENST00000497031 ENST00000464228

ENST00000460720 ENST00000465527 ENST00000359712(uc002qzn.1) ENST00000488451

ENST00000470507 ENST00000456913 ENST00000482798 ENST00000492079 ENST00000463190

ENST00000494563 ENST00000467606

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		hsa-miR-33a* hsa-miR-4307 hsa-miR-409-3p hsa-miR-1208 hsa-miR-642b
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Additional cDNA sequence:

AK093179.1 AK289817.1 AK299017.1 BC012264.1 BX647099.1 CR457006.1

24/27 DOTS entries (see all 27):

DT.100715086 DT.318419 DT.454691 DT.95162361 DT.100824055 DT.121022248 DT.100824057 DT.100824054

DT.121022190 DT.91775256 DT.121022166 DT.100037672 DT.100675702 DT.100824056 DT.100824060 DT.95162360

DT.101962374 DT.97847693 DT.121022147 DT.121022216 DT.121022238 DT.121022273 DT.91775217 DT.95162357

24/258 AceView cDNA sequences (see all 258):

BM773118 AI094079 BG120698 BQ020968 AA418643 BQ675005 F28999 AA047376

AI784492 BE869334 CR604571 AA291207 AA759141 BQ446973 BQ028955 BU521344

BU520903 CA314299 AA047254 BU686561 BM823938 BM559109 CD106087 BM701513

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ITGB1BP1 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	·	3g	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^
SP1:													-		-		-		-		-		-		-		-		-		-		-																		-
SP2:													-		-		-		-		-		-		-		-		-		-		-																		-
SP3:													-		-		-		-		-		-		-		-		-		-		-																		-
SP4:													-		-		-		-		-		-		-		-		-		-		-				-		-												-
SP5:													-		-		-		-		-		-		-		-		-		-		-		-																-

ExUns:	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	·	11d
SP1:					-						-
SP2:					-		-				-
SP3:					-		-		-		-
SP4:					-						-
SP5:					-						-

ECgene alternative splicing isoforms for ITGB1BP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGB1BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTCTACTT

About this image
See ITGB1BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGB1BP1

SOURCE GeneReport for Unigene cluster: Hs.467662

UniProtKB/Swiss-Prot: ITBP1_HUMAN, O14713

Tissue specificity: Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate

SABiosciences Custom PCR Arrays for ITGB1BP1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ITGB1BP1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Itgb1bp1^{1 , 5}	integrin beta 1 binding protein 1^{1, 5}	84.25(n)¹ 94.47(a)¹		12 (8.30 cM)⁵ 16413¹ NM_008403.4¹ NP_032429.1¹ 21240825⁵
chicken (Gallus gallus)	Aves	ITGB1BP1¹	integrin beta 1 binding protein 1	81.74(n) 93.47(a)		421928 XM_419941.3 XP_419941.3
lizard (Anolis carolinensis)	Reptilia	ITGB1BP1⁶	--	92(a)	1 ↔ 1	1(148497669-148504594)
zebrafish (Danio rerio)	Actinopterygii	itgb1bp1¹	integrin beta 1 binding protein 1	71.72(n) 78.79(a)		641420 NM_001037409.1 NP_001032486.1

ENSEMBL Gene Tree for ITGB1BP1 (if available)
TreeFam Gene Tree for ITGB1BP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGB1BP1 gene

ITGB1BP1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ITGB1BP1
PGOHUM00000245135

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28556889^1,2	F	--	9546357(+)	`CATCTA/CGTCTT`	2	--	ut3¹		2		NA	8
rs78175695^1,2	F	--	9546359(+)	`TCTCGT/GCTTCC`	2	--	ut3¹		2		NA	8
rs113193174^1,2	C	--	9546376(+)	`CTTCAA/GTGTGT`	2	--	ut3¹		2		WA NA	4
rs28570521^1,2	F	--	9546413(+)	`CATCTC/AGTCTT`	2	--	ut3¹		1		NA	6
rs13392033^1,2	C	--	9546440(+)	`TGTGTG/TTGTCA`	2	--	ut3¹		1		NA	2
rs4669388^1,2	C,A	--	9546469(+)	`CATCTA/CGTCTT`	2	--	ut3¹		0	--	--	--	--
rs5026136^1,2	C	--	9546471(+)	`TCTAGG/TCTTCC`	2	--	ut3¹		2		NA	4
rs112706460^1,2	C,F	--	9546488(+)	`CTTCAG/ATGTGT`	2	--	ut3¹		2		WA NA	4
rs13392125^1,2	C,F	--	9546496(+)	`TGTGTG/TTGTCA`	2	--	ut3¹		2		WA NA	4
rs13427177^1,2	C	--	9546525(+)	`CATCTA/CGTCTT`	2	--	ut3¹		1		NA	2

HapMap Linkage Disequilibrium report for ITGB1BP1 (9543604 - 9563676 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ITGB1BP1
1 CNV: 97763
3 Indels: 78420 89468 72598

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ITGB1BP1 for disorders           About GeneDecksing

OMIM gene information: 607153    OMIM disorders: --

7 diseases for ITGB1BP1:    About MalaCards

cerebral cavernous malformations-1 cerebral cavernous malformations cavernous malformation cerebritis

breast cancer prostatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: ITGB1BP1 (1 document)

Export disorders for ITGB1BP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITGB1BP1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with ITGB1BP1)

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ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. (PubMed id 9281591)^{1, 2, 3, 9} Chang D.D.... Liu J. (1997)
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. (PubMed id 11854171)^{1, 3, 9} Zawistowski J.S....Marchuk D.A. (2002)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular basis for interaction between Icap1alpha PTB domain and beta 1 integrin. (PubMed id 11741908)^{1, 2} Chang D.D.... Springer T.A. (2002)
Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha. (PubMed id 9813144)^{1, 2} Bouvard D. and Block M.R. (1998)
Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation. (PubMed id 15703214)^{1, 9} Fournier H.N....Albiges-Rizo C. (2005)
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. (PubMed id 11741838)^{1, 9} Zhang J....Dietz H.C. (2001)
krit1 modulates beta1-integrin-mediated endothelial cell proliferation. (PubMed id 18812969)^{1, 9} Zhang J....Clatterbuck R.E. (2008)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9270	HGNC: 23927	AceView: ITGB1BP1	Ensembl:ENSG00000119185	euGenes: HUgn9270
ECgene: ITGB1BP1	H-InvDB: ITGB1BP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGB1BP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ITGB1BP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGB1BP1 gene:
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GeneCards and IP:
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integrin beta 1 binding protein 1

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integrin beta 1 binding protein 1

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