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Aliases for ITGB1 Gene

Aliases for ITGB1 Gene

  • Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29 Includes MDF2, MSK12) 2 3
  • Glycoprotein IIa 3 4
  • MSK12 3 4
  • GPIIA 3 4
  • MDF2 3 4
  • FNRB 3 4
  • Very Late Activation Protein, Beta Polypeptide 3
  • Fibronectin Receptor Subunit Beta 4
  • Integrin VLA-4 Beta Subunit 3
  • Antigen CD29 Includes MDF2 6
  • VLA-4 Subunit Beta 4
  • Integrin Beta-1 3
  • CD29 Antigen 4
  • VLA-BETA 3
  • MSK12) 6
  • CD29 3
  • VLAB 3

External Ids for ITGB1 Gene

Previous HGNC Symbols for ITGB1 Gene

  • FNRB
  • MSK12
  • MDF2

Previous GeneCards Identifiers for ITGB1 Gene

  • GC10M033339
  • GC10M033193
  • GC10M033164
  • GC10M033229
  • GC10M033189

Summaries for ITGB1 Gene

Entrez Gene Summary for ITGB1 Gene

  • Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGB1 Gene

ITGB1 (Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29 Includes MDF2, MSK12)) is a Protein Coding gene. Diseases associated with ITGB1 include fraser syndrome and frozen shoulder. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include protein heterodimerization activity and protein kinase binding. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot for ITGB1 Gene

  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.

  • Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.

Tocris Summary for ITGB1 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB1 Gene

Genomics for ITGB1 Gene

Regulatory Elements for ITGB1 Gene

Transcription factor binding sites by QIAGEN in the ITGB1 gene promoter:

Genomic Location for ITGB1 Gene

Start:
32,900,318 bp from pter
End:
33,005,792 bp from pter
Size:
105,475 bases
Orientation:
Minus strand

Genomic View for ITGB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB1 Gene

Proteins for ITGB1 Gene

  • Protein details for ITGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05556-ITB1_HUMAN
    Recommended name:
    Integrin beta-1
    Protein Accession:
    P05556
    Secondary Accessions:
    • A8K6N2
    • D3DRX9
    • D3DRY3
    • D3DRY4
    • D3DRY5
    • P78466
    • P78467
    • Q13089
    • Q13090
    • Q13091
    • Q13212
    • Q14622
    • Q14647
    • Q29RW2
    • Q7Z3V1
    • Q8WUM6

    Protein attributes for ITGB1 Gene

    Size:
    798 amino acids
    Molecular mass:
    88415 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity).
    SequenceCaution:
    • Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGB1 Gene

    Alternative splice isoforms for ITGB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB1 Gene

Proteomics data for ITGB1 Gene at MOPED

Post-translational modifications for ITGB1 Gene

  • The cysteine residues are involved in intrachain disulfide bonds.
  • Ubiquitination at Lys774, Lys784, and Lys794
  • Glycosylation at Asn50, Asn94, Asn97, Asn212, Asn269, Asn363, Thr394, Asn403, Asn406, Asn411, Asn417, Asn481, Asn520, Asn584, and Asn669
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGB1 Gene

Domains for ITGB1 Gene

Gene Families for ITGB1 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGB1 Gene

Graphical View of Domain Structure for InterPro Entry

P05556

UniProtKB/Swiss-Prot:

ITB1_HUMAN :
  • P05556
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB1: view

Function for ITGB1 Gene

Molecular function for ITGB1 Gene

GENATLAS Biochemistry: integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes
UniProtKB/Swiss-Prot Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
UniProtKB/Swiss-Prot Function: Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.

Gene Ontology (GO) - Molecular Function for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001948 glycoprotein binding IEA --
GO:0001968 fibronectin binding IEA --
GO:0002020 protease binding IPI 10455171
GO:0003779 actin binding IDA 16803572
genes like me logo Genes that share ontologies with ITGB1: view
genes like me logo Genes that share phenotypes with ITGB1: view

Animal Models for ITGB1 Gene

MGI Knock Outs for ITGB1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGB1 Gene

Localization for ITGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB1 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269 PubMed:10455171, ECO:0000303 PubMed:10455171}.
Isoform 5: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGB1 Gene COMPARTMENTS Subcellular localization image for ITGB1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 3
cytoskeleton 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0001726 ruffle TAS 11919189
GO:0005604 basement membrane IEA --
GO:0005737 cytoplasm IDA 16803572
GO:0005768 endosome --
genes like me logo Genes that share ontologies with ITGB1: view

Pathways for ITGB1 Gene

genes like me logo Genes that share pathways with ITGB1: view

Gene Ontology (GO) - Biological Process for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001708 cell fate specification IEA --
GO:0001894 tissue homeostasis IEA --
GO:0002042 cell migration involved in sprouting angiogenesis IEA --
genes like me logo Genes that share ontologies with ITGB1: view

Compounds for ITGB1 Gene

(5) Tocris Compounds for ITGB1 Gene

Compound Action Cas Number
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 [327613-57-0]
Eptifibatide Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation [188627-80-7]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(1) Drugbank Compounds for ITGB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antithymocyte globulin
  • rabbit ATG
target

(64) Novoseek inferred chemical compound relationships for ITGB1 Gene

Compound -log(P) Hits PubMed IDs
grgdsp 65.5 1
kalinin 63.9 1
herbimycin a 57.6 4
tyrosine 48.7 49
matrigel 48.7 2
genes like me logo Genes that share compounds with ITGB1: view

Transcripts for ITGB1 Gene

Unigene Clusters for ITGB1 Gene

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB1 Gene

No ASD Table

Relevant External Links for ITGB1 Gene

GeneLoc Exon Structure for
ITGB1
ECgene alternative splicing isoforms for
ITGB1

Expression for ITGB1 Gene

mRNA expression in normal human tissues for ITGB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB1 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGB1 Gene

SOURCE GeneReport for Unigene cluster for ITGB1 Gene Hs.643813

mRNA Expression by UniProt/SwissProt for ITGB1 Gene

P05556-ITB1_HUMAN
Tissue specificity: Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
genes like me logo Genes that share expressions with ITGB1: view

Orthologs for ITGB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB1 35
  • 99.67 (n)
  • 99.62 (a)
ITGB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGB1 35
  • 90.23 (n)
  • 94.24 (a)
ITGB1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB1 35
  • 92.44 (n)
  • 95.24 (a)
ITGB1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb1 35
  • 87.72 (n)
  • 92.48 (a)
Itgb1 16
Itgb1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgb1 35
  • 87.05 (n)
  • 92.11 (a)
chicken
(Gallus gallus)
Aves ITGB1 35
  • 78.8 (n)
  • 85.14 (a)
ITGB1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7623 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itgb1 35
  • 74.87 (n)
  • 81.28 (a)
MGC76178 35
zebrafish
(Danio rerio)
Actinopterygii itgb1a 35
  • 68.93 (n)
  • 78.17 (a)
itgb1a 36
  • 78 (a)
OneToMany
itgb1b 36
  • 76 (a)
OneToMany
itgb1b.1 36
  • 66 (a)
OneToMany
itgb1b.2 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta INTB 35
  • 49.46 (n)
  • 47.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta mys 35
  • 51.11 (n)
  • 47.58 (a)
mys 36
  • 41 (a)
OneToMany
bgrInt-ngr 37
  • 31 (a)
mys 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 35
  • 51.86 (n)
  • 43.35 (a)
pat-3 36
  • 39 (a)
OneToMany
pat-3 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.871 36
  • 39 (a)
OneToMany
Species with no ortholog for ITGB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB1 Gene

ENSEMBL:
Gene Tree for ITGB1 (if available)
TreeFam:
Gene Tree for ITGB1 (if available)

Paralogs for ITGB1 Gene

Pseudogenes.org Pseudogenes for ITGB1 Gene

genes like me logo Genes that share paralogs with ITGB1: view

Variants for ITGB1 Gene

Sequence variations from dbSNP and Humsavar for ITGB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7217 -- 32,900,729(-) TTTCT(A/G)TCACC utr-variant-3-prime
rs17468 -- 32,901,357(-) GGTTA(C/T)TCTTG utr-variant-3-prime
rs1009002 -- 32,947,973(-) TACGT(C/T)GTTAT intron-variant
rs1049433 -- 32,900,536(-) TGTAT(A/G)TTTAC utr-variant-3-prime
rs1187068 -- 32,947,325(+) ACTGC(C/T)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB1 Gene

Variant ID Type Subtype PubMed ID
nsv831827 CNV Loss 17160897
esv23179 CNV Loss 19812545
esv999118 CNV Loss 20482838

Relevant External Links for ITGB1 Gene

HapMap Linkage Disequilibrium report
ITGB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB1 Gene

Disorders for ITGB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for ITGB1 Gene including...

Search for ITGB1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ITGB1 Gene

(81) Novoseek inferred disease relationships for ITGB1 Gene

Disease -log(P) Hits PubMed IDs
melanoma 38.7 26
tumors 38.3 63
metastasis 34 13
myeloma 27.1 6
fibrosarcoma 25.6 1

Relevant External Links for ITGB1

Genetic Association Database (GAD)
ITGB1
Human Genome Epidemiology (HuGE) Navigator
ITGB1
genes like me logo Genes that share disorders with ITGB1: view

No data available for UniProtKB/Swiss-Prot for ITGB1 Gene

Publications for ITGB1 Gene

  1. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. (PMID: 8630057) Radford K.J. … Hersey P. (Biochem. Biophys. Res. Commun. 1996) 3 23
  2. The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly. (PMID: 8163531) Lenter M. … Vestweber D. (J. Biol. Chem. 1994) 3 23
  3. Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization. (PMID: 9812906) Scherberich A. … Beretz A. (Arterioscler. Thromb. Vasc. Biol. 1998) 3 23
  4. The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking. (PMID: 11208159) Wang J. … Howell K.E. (Traffic 2000) 3 23
  5. Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. (PMID: 11553610) Wang J.F. … Groopman J.E. (J. Biol. Chem. 2001) 3 23

Products for ITGB1 Gene

  • Addgene plasmids for ITGB1

Sources for ITGB1 Gene

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