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ITGB1 Gene(Protein Coding)

Integrin Subunit Beta 1

GCID:
GC10M032936
GIFtS:
71
Genes Participants
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Aliases for ITGB1 Gene

Aliases for ITGB1 Gene

  • Integrin Subunit Beta 1 2 3 5
  • Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29 Includes MDF2, MSK12) 2 3
  • Glycoprotein IIa 3 4
  • MSK12 3 4
  • GPIIA 3 4
  • FNRB 3 4
  • MDF2 3 4
  • Very Late Activation Protein, Beta Polypeptide 3
  • Fibronectin Receptor Subunit Beta 4
  • Integrin VLA-4 Beta Subunit 3
  • VLA-4 Subunit Beta 4
  • Integrin Beta 1 3
  • Integrin Beta-1 3
  • CD29 Antigen 4
  • VLA-BETA 3
  • CD29 3
  • VLAB 3

External Ids for ITGB1 Gene

Previous HGNC Symbols for ITGB1 Gene

  • FNRB
  • MSK12
  • MDF2

Previous GeneCards Identifiers for ITGB1 Gene

  • GC10M033339
  • GC10M033193
  • GC10M033164
  • GC10M033229
  • GC10M033189

Summaries for ITGB1 Gene

Entrez Gene Summary for ITGB1 Gene

  • Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGB1 Gene

ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Cerebral Hypoxia and Hydrocele. Among its related pathways are GPCR Pathway and MAPK-Erk Pathway. GO annotations related to this gene include protein heterodimerization activity and receptor binding. An important paralog of this gene is ITGB2.

UniProtKB/Swiss-Prot for ITGB1 Gene

  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).

  • Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.

  • (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Tocris Summary for ITGB1 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGB1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB1 Gene

Genomics for ITGB1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ITGB1 Gene

Enhancers for ITGB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G032947 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +50.2 50236 17.1 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 ZNF610 GLIS1 LOC105376486 ITGB1 CCDC7 LOC101929475 AK3P5
GH10G033031 0.9 Ensembl ENCODE 11.7 -27.1 -27087 1.9 JUN HLF MAX SIN3A EP300 NR2F2 JUND MAFF GATA2 FOS ITGB1 LOC105376486 NRP1 RN7SL847P MTND4LP11
GH10G032929 0.8 ENCODE dbSUPER 11.4 +76.0 75985 0.2 GATA3 RAD21 ZBTB40 FOXA1 ITGB1 AK3P5 LOC105376486
GH10G032795 0.7 ENCODE 12.2 +210.0 210005 0.2 CTCF ZNF654 FOXA2 FOXA3 TRIM22 REST ZNF2 RAD21 FOXA1 JUND ITGB1 GC10M032819 PIR43634
GH10G032445 1.1 ENCODE 7.3 +559.2 559181 3.1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 LOC105376486 EPC1 ITGB1 CCDC7 GC10M032511
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGB1 on UCSC Golden Path with GeneCards custom track

Promoters for ITGB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000026579 192 801 PKNOX1 FOXA2 ARID4B SIN3A YY1 FOS SMARCB1 KAT8 SMARCA4 ZNF585B

Transcription factor binding sites by QIAGEN in the ITGB1 gene promoter:

Genomic Location for ITGB1 Gene

Chromosome:
10
Start:
32,900,318 bp from pter
End:
33,005,792 bp from pter
Size:
105,475 bases
Orientation:
Minus strand

Genomic View for ITGB1 Gene

Genes around ITGB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGB1 Gene

Proteins for ITGB1 Gene

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  • Protein details for ITGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05556-ITB1_HUMAN
    Recommended name:
    Integrin beta-1
    Protein Accession:
    P05556
    Secondary Accessions:
    • A8K6N2
    • D3DRX9
    • D3DRY3
    • D3DRY4
    • D3DRY5
    • P78466
    • P78467
    • Q13089
    • Q13090
    • Q13091
    • Q13212
    • Q14622
    • Q14647
    • Q29RW2
    • Q7Z3V1
    • Q8WUM6

    Protein attributes for ITGB1 Gene

    Size:
    798 amino acids
    Molecular mass:
    88415 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity). ITGA5:ITGB1 interacts with NOV. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881).
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.
    • (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.
    • (Microbial infection) Interacts with mammalian reovirus capsid proteins.
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.
    SequenceCaution:
    • Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGB1 Gene

    Alternative splice isoforms for ITGB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB1 Gene

Protein Expression for ITGB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGB1 Gene

  • The cysteine residues are involved in intrachain disulfide bonds.
  • Ubiquitination at isoforms=794
  • Glycosylation at posLast=5050, isoforms=2, 3, 4, 594, posLast=9797, posLast=212212, isoforms=2, 3, 4, 5269, isoforms=2, 3, 4, 5363, isoforms=2, 3, 4, 5394, posLast=403403, isoforms=2, 3, 4, 5406, posLast=411411, posLast=417417, posLast=481481, posLast=520520, posLast=584584, and posLast=669669
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
  • Cell Signaling Technology (CST) Antibodies for ITGB1 (ITGB1)

Assay Products

  • Cloud-Clone Corp Assay Kits for ITGB1

No data available for DME Specific Peptides for ITGB1 Gene

Domains & Families for ITGB1 Gene

Gene Families for ITGB1 Gene

HGNC:

Protein Domains for ITGB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ITGB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05556

UniProtKB/Swiss-Prot:

ITB1_HUMAN :
  • Belongs to the integrin beta chain family.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB1: view

Function for ITGB1 Gene

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  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for ITGB1 Gene

GENATLAS Biochemistry:
integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes
UniProtKB/Swiss-Prot Function:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
UniProtKB/Swiss-Prot Function:
Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Gene Ontology (GO) - Molecular Function for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001968 fibronectin binding IPI 11792823
GO:0002020 protease binding IPI 10455171
GO:0003779 actin binding IDA 16803572
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with ITGB1: view
genes like me logo Genes that share phenotypes with ITGB1: view

Animal Models for ITGB1 Gene

MGI Knock Outs for ITGB1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGB1
  • R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB1 Gene

Localization for ITGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB1 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269 PubMed:10455171, ECO:0000303 PubMed:10455171}.
Isoform 5: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGB1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 4
cytoskeleton 3
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005737 cytoplasm IDA 16803572
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 colocalizes_with focal adhesion IEA,IDA 14970227
genes like me logo Genes that share ontologies with ITGB1: view

Pathways & Interactions for ITGB1 Gene

genes like me logo Genes that share pathways with ITGB1: view

Pathways by source for ITGB1 Gene

3 Cell Signaling Technology pathways for ITGB1 Gene
2 Tocris pathways for ITGB1 Gene

SIGNOR curated interactions for ITGB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001708 cell fate specification IEA --
GO:0002042 cell migration involved in sprouting angiogenesis IEA --
GO:0006968 cellular defense response TAS 10201960
genes like me logo Genes that share ontologies with ITGB1: view

Drugs & Compounds for ITGB1 Gene

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(61) Drugs for ITGB1 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target 0
ATL1102 Investigational Pharma antisense 0
R1295 Investigational Pharma antagonist 0
Firategrast Pharma antagonist α4β1/α4β7 integrin antagonist 0
BIO 1211 Pharma α4β1 inhibitor,selective and high affinity, Selective alpha4beta1 (VLA-4) inhibitor 0

(31) Additional Compounds for ITGB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BTT 3033
1259028-99-3

(5) Tocris Compounds for ITGB1 Gene

Compound Action Cas Number
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor 187735-94-0
BTT 3033 Selective inhibitor of integrin alpha2beta1 1259028-99-3
Cilengitide Potent and selective inhibitor of integrins alphavbeta3 and alphavbeta5 188968-51-6
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo 916734-43-5

(15) ApexBio Compounds for ITGB1 Gene

Compound Action Cas Number
BIO 1211 α4β1 inhibitor,selective and high affinity 187735-94-0
BIO 5192 Integrin α4β1 inhibitor 327613-57-0
CWHM-12 1564286-55-0
Echistatin, α1 isoform 154303-05-6
Firategrast α4β1/α4β7 integrin antagonist 402567-16-2
GR 144053 trihydrochloride 1215333-48-4
LDV FITC 1207610-07-8
Obtustatin
P11 848644-86-0
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
RGDS peptide 91037-65-9
TC-I 15 916734-43-5
TCS 2314 317353-73-4
TR-14035 α4β7 and α4β1 integrins antagonist 232271-19-1
Zaurategrast Integrin inhibitor 455264-31-0
genes like me logo Genes that share compounds with ITGB1: view

Drug Products

Transcripts for ITGB1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ITGB1 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1076) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITGB1 Gene

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGB1
  • R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB1 Gene

No ASD Table

Relevant External Links for ITGB1 Gene

GeneLoc Exon Structure for
ITGB1
ECgene alternative splicing isoforms for
ITGB1

Expression for ITGB1 Gene

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  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGB1 Gene

mRNA expression in normal human tissues for ITGB1 Gene
mRNA expression by BioGPS for ITGB1 GenemRNA expression by GTEx for ITGB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB1 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for ITGB1 Gene

This gene is overexpressed in Amniocyte (7.7) and Seminal vesicle (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGB1 Gene



Protein tissue co-expression partners for ITGB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGB1 Gene:

ITGB1

SOURCE GeneReport for Unigene cluster for ITGB1 Gene:

Hs.643813

mRNA Expression by UniProt/SwissProt for ITGB1 Gene:

P05556-ITB1_HUMAN
Tissue specificity: Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).

Evidence on tissue expression from TISSUES for ITGB1 Gene

  • Muscle(4.9)
  • Skin(4.9)
  • Liver(4.8)
  • Bone marrow(4.7)
  • Heart(4.7)
  • Nervous system(4.7)
  • Lung(4.3)
  • Intestine(4)
  • Pancreas(3.8)
  • Kidney(3.7)
  • Bone(3.5)
  • Blood(3.2)
  • Spleen(3.1)
  • Lymph node(2.8)
  • Eye(2.7)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ITGB1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGB1 Gene

Orthologs for ITGB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ITGB1 34 35
  • 99.67 (n)
dog
(Canis familiaris)
 Mammalia ITGB1 34 35
  • 92.44 (n)
cow
(Bos Taurus)
 Mammalia ITGB1 34 35
  • 90.23 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 90 (a)
 OneToMany
-- 35
  • 46 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia ITGB1 35
  • 89 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Itgb1 34 16 35
  • 87.72 (n)
rat
(Rattus norvegicus)
 Mammalia Itgb1 34
  • 87.05 (n)
chicken
(Gallus gallus)
 Aves ITGB1 34 35
  • 78.8 (n)
lizard
(Anolis carolinensis)
 Reptilia ITGB1 35
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia itgb1 34
  • 74.87 (n)
MGC76178 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7623 34
zebrafish
(Danio rerio)
 Actinopterygii itgb1b 35
  • 76 (a)
 OneToMany
itgb1a 34 35
  • 68.93 (n)
itgb1b.1 35
  • 66 (a)
 OneToMany
itgb1b.2 35
  • 61 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta mys 36 34 35
  • 51.11 (n)
bgrInt-ngr 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta INTB 34
  • 49.46 (n)
worm
(Caenorhabditis elegans)
 Secernentea pat-3 36 34 35
  • 51.86 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.871 35
  • 39 (a)
 OneToMany
Species where no ortholog for ITGB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB1 Gene

ENSEMBL:
Gene Tree for ITGB1 (if available)
TreeFam:
Gene Tree for ITGB1 (if available)

Paralogs for ITGB1 Gene

Paralogs for ITGB1 Gene

(6) SIMAP similar genes for ITGB1 Gene using alignment to 14 proteins:

Pseudogenes.org Pseudogenes for ITGB1 Gene

genes like me logo Genes that share paralogs with ITGB1: view

Variants for ITGB1 Gene

Sequence variations from dbSNP and Humsavar for ITGB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000047047 -- 32,947,313(+) GAAAG(A/G)AAGAA intron-variant
rs1000100800 -- 32,939,764(+) AGTGA(A/G)TGAGA intron-variant
rs1000132030 -- 32,913,428(+) AAAGA(C/G)TAGAC intron-variant
rs1000168827 -- 32,930,347(+) AATTG(A/T)GCATG intron-variant
rs1000200782 -- 32,912,515(+) AGAGG(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB1 Gene

Variant ID Type Subtype PubMed ID
dgv1031n54 CNV loss 21841781
esv23179 CNV loss 19812545
esv3622842 CNV loss 21293372
esv999118 CNV loss 20482838
nsv1069469 CNV deletion 25765185
nsv550383 CNV loss 21841781
nsv831827 CNV loss 17160897
nsv947823 CNV duplication 23825009

Variation tolerance for ITGB1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGB1 Gene

Human Gene Mutation Database (HGMD)
ITGB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB1 Gene

Disorders for ITGB1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for ITGB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral hypoxia
  • brain hypoxia
hydrocele
  • testicular hydrocele
mast cell disease
  • maculopapular cutaneous mastocytosis
pustulosis palmaris et plantaris
  • localized pustular psoriasis
fraser syndrome
  • cryptophthalmos syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ITGB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGB1

Genetic Association Database (GAD)
ITGB1
Human Genome Epidemiology (HuGE) Navigator
ITGB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGB1
genes like me logo Genes that share disorders with ITGB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB1 Gene

Publications for ITGB1 Gene

  1. Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. (PMID: 23317506) Liu W. … Boggon T.J. (Mol. Cell 2013) 3 4 64
  2. Integrins I+vI^3 and I+4I^1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. (PMID: 23125415) Fujita M. … Takada Y. (J. Immunol. 2012) 3 4 64
  3. Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M. … Takagi J. (J. Cell Biol. 2012) 3 4 64
  4. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. (PMID: 21325030) Qu H. … Wu C. (J. Cell Sci. 2011) 3 4 64
  5. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin I^1 recycling in cell migration. (PMID: 22027826) Yu X. … Yao X. (J. Biol. Chem. 2011) 3 4 64

Products for ITGB1 Gene

  • Addgene plasmids for ITGB1