Aliases for ITGB1 Gene
Aliases for ITGB1 Gene
External Ids for ITGB1 Gene
- HGNC: 6153
- Entrez Gene: 3688
- Ensembl: ENSG00000150093
- OMIM: 135630
- UniProtKB: P05556
Previous HGNC Symbols for ITGB1 Gene
- FNRB
- MSK12
- MDF2
Previous GeneCards Identifiers for ITGB1 Gene
- GC10M033339
- GC10M033193
- GC10M033164
- GC10M033229
- GC10M033189
Summaries for ITGB1 Gene
-
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGB1 Gene
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Cerebral Hypoxia and Hydrocele. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and CXCR4-mediated signaling events. GO annotations related to this gene include protein heterodimerization activity and receptor binding. An important paralog of this gene is ITGB2.
UniProtKB/Swiss-Prot for ITGB1 Gene
-
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
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Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.
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(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).
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Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB1 Gene
Genomics for ITGB1 Gene
Regulatory Elements for ITGB1 Gene
Enhancers for ITGB1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10F032947 | 1.7 | FANTOM5 Ensembl ENCODE | 12.1 | +50.2 | 50238 | 17.1 | PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 | LOC105376486 ITGB1 ENSG00000150076 LOC101929475 AK3P5 |
| GH10F033031 | 0.9 | Ensembl ENCODE | 11.7 | -27.1 | -27087 | 1.9 | JUN HLF MAX SIN3A EP300 NR2F2 JUND MAFK TCF7L2 | ITGB1 LOC105376486 NRP1 RN7SL847P MTND4LP11 |
| GH10F032795 | 0.7 | ENCODE | 12.2 | +210.0 | 210005 | 0.2 | CTCF ZNF654 FOXA3 TRIM22 REST ZNF2 RAD21 JUND FOXK2 SMC3 | ITGB1 GC10M032819 PIR43634 |
| GH10F032445 | 1.1 | ENCODE | 7.3 | +559.2 | 559181 | 3.1 | PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 CBX5 ZNF143 ZNF207 | LOC105376486 EPC1 ITGB1 CCDC7 GC10M032511 |
| GH10F033213 | 1.5 | FANTOM5 Ensembl ENCODE | 5.3 | -210.7 | -210686 | 5.5 | PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 FOS JUNB | NRP1 ITGB1 ENSG00000238258 GC10M033237 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ITGB1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ITGB1 gene promoter:
Regulatory Element Products
Genomic Location for ITGB1 Gene
- Chromosome:
- 10
- Start:
- 32,900,318 bp from pter
- End:
- 33,005,792 bp from pter
- Size:
- 105,475 bases
- Orientation:
- Minus strand
Genomic View for ITGB1 Gene
Genes around ITGB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.22 by Ensembl
- 10p11.22 by Entrez Gene
- 10p11.22 by HGNC
ITGB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGB1 Gene
Proteins for ITGB1 Gene
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Protein details for ITGB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05556-ITB1_HUMAN
- Recommended name:
- Integrin beta-1
- Protein Accession:
- P05556
- A8K6N2
- D3DRX9
- D3DRY3
- D3DRY4
- D3DRY5
- P78466
- P78467
- Q13089
- Q13090
- Q13091
- Q13212
- Q14622
- Q14647
- Q29RW2
- Q7Z3V1
- Q8WUM6
Protein attributes for ITGB1 Gene
- Size:
- 798 amino acids
- Molecular mass:
- 88415 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity). ITGA5:ITGB1 interacts with NOV. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881).
- (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.
- (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.
- (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.
- (Microbial infection) Interacts with mammalian reovirus capsid proteins.
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.
- SequenceCaution:
-
- Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ITGB1 Gene
Protein Expression for ITGB1 Gene
Post-translational modifications for ITGB1 Gene
- The cysteine residues are involved in intrachain disulfide bonds.
- Ubiquitination at Lys 794
- Glycosylation at Asn 50, Asn 94, Asn 97, Asn 212, Asn 269, Asn 363, Thr 394, Asn 403, Asn 406, Asn 411, Asn 417, Asn 481, Asn 520, Asn 584, and Asn 669
- Modification sites at PhosphoSitePlus
Other Protein References for ITGB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top ITGB1 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ITGB1
- R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
- Cell Signaling Technology (CST) Antibodies for ITGB1 (ITGB1)
-
Custom Antibody ServicesOriGene Antibodies for ITGB1
- AM06734PU-N
- AM06735PU-N
- AM09002PU-N
- AM09002PU-S
- AM31183AF-N
- CF807138
- TA807138
- CF806909
- TA806909
- TA353270
- TA353269
- TA353268
- TA352676
- TA352640
- TA352317
- TA352316
- TA349358
- TA347998
- TA341149
- TA341143
- TA328165
- TA320394
- TA320393
- TA320392
- TA311971
- TA311970
- TA311969
- TA311968
- SM3016R
- SM3016P
- SM3016F
- SM3016B
- SM3016APC
- SM2210PT
- SM2210PS
- SM2210P
- SM2210LE
- SM2210FX
- SM2210FT
- SM2210F
- SM2210B
- SM2118P
- SM1740PT
- SM1740P
- SM1578PT
- SM1578PS
- SM1578P
- SM1578FT
- SM1578F
- BM6029P
- BM6028P
- BM2540
- AP55840PU-S
- AP55840PU-N
- AP55700PU-S
- AP55700PU-N
- AP20348PU-N
- AP06431PU-N
- AM32361PU-N
- AM32089PU-N
- AM32088PU-N
- AM31183RP-N
- AM31183PU-S
- AM31183PU-N
- AM31183FC-N
- Novus Biologicals Antibodies for ITGB1
-
Abcam antibodies for ITGB1
-
Cloud-Clone Corp. Antibodies for ITGB1
- Invitrogen Antibodies for ITGB1
- antibodies-online Antibodies for ITGB1: See all 637
- GeneTex ITGB1 antibody for ITGB1
-
St John's Laboratory Antibodies for ITGB1
- integrin-b1-antibody-p-98913
- integrin-b1-antibody-p-92812
- integrin-b1-antibody-p-92811
- integrin-b1-antibody
- phospho-integrin-b1-t789-antibody
- phospho-integrin-b1-y795-antibody
- phospho-integrin-b1-t788-antibody
- anti-itgb1-cd29-antibody
- anti-integrin-beta-1-antibody
- anti-itgb1-antibody
- anti-integrin-b1-antibody
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Santa Cruz Biotechnology (SCBT) Antibodies for ITGB1
- Integrin beta1 (4B7R)
- Integrin alpha2 (P1H5)
- Integrin beta1 (P5D2)
- Integrin beta1 (P4G11)
- Integrin beta1 (K-20)
- Integrin beta1 (MEM-101A)
- Integrin beta1 (TS2/16)
- Integrin beta1 (12G10)
- Integrin beta1 (JB1B)
- Integrin alpha2/beta1 (16B4)
- Integrin alpha9/beta1 (Y9A2)
- Integrin betaId (1G2)
- Integrin betaId (2B1)
- Integrin beta1 (2Q837)
- Integrin beta1 (3H1192)
- Integrin alpha9/beta1 (2Q954)
- Integrin alpha2/beta1 (2B2.29)
- Integrin alpha2/beta1 (3H1472)
- Integrin beta1 (102DF5)
- Integrin beta1 (A-4)
- Integrin beta1 (E-11)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGB1
- Origene Custom Protein Services for ITGB1
- Sino Biological Cell Lysates for ITGB1
- Sino Biological Recombinant Proteins for ITGB1
-
Cloud-Clone Corp. Proteins for ITGB1
- antibodies-online Proteins for ITGB1: See all 23
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ITGB1
Assay Products
- EMD Millipore Kits and Assays for ITGB1
-
Custom Assay ServicesOriGene ELISA Kits for ITGB1
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGB1 (Integrin beta 1/CD29)
-
Cloud-Clone Corp Assay Kits for ITGB1
- antibodies-online Kits for ITGB1: See all 21
No data available for DME Specific Peptides for ITGB1 Gene
Domains & Families for ITGB1 Gene
Gene Families for ITGB1 Gene
Protein Domains for ITGB1 Gene
Suggested Antigen Peptide Sequences for ITGB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05556UniProtKB/Swiss-Prot:
ITB1_HUMAN :- Contains 1 VWFA domain.
- Belongs to the integrin beta chain family.
- Domain:
-
- Contains 1 VWFA domain.
- Family:
-
- Belongs to the integrin beta chain family.
Function for ITGB1 Gene
Molecular function for ITGB1 Gene
- GENATLAS Biochemistry:
- integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes
- UniProtKB/Swiss-Prot Function:
- Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
- UniProtKB/Swiss-Prot Function:
- Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0001968 | fibronectin binding | IPI | 11792823 |
| GO:0002020 | protease binding | IPI | 10455171 |
| GO:0003779 | actin binding | IDA | 16803572 |
| GO:0004872 | receptor activity | IEA | -- |
Phenotypes for ITGB1 Gene
- MGI mutant phenotypes for ITGB1:
-
inferred from 26 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- growth/size/body region phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- normal phenotype
- muscle phenotype
- respiratory system phenotype
- immune system phenotype
- cardiovascular system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- liver/biliary system phenotype
- integument phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- embryo phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for ITGB1:
-
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Increased number of mitotic cells
- Decreased Salmonella enterica Typhimurium invasion
- Decreased cell migration
- Increased HPV16-GFP infection
- Synthetic lethal with imatinib mesylate
Animal Models for ITGB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
- Search ViGene Biosciences for ITGB1
CRISPR Products
-
OriGene CRISPR knockouts for ITGB1
- GenScript: Design CRISPR guide RNA sequences for ITGB1
miRNA for ITGB1 Gene
- miRTarBase miRNAs that target ITGB1
-
- hsa-mir-124-3p (MIRT002731)
- gga-mir-124a-3p (MIRT003906)
- hsa-mir-183-5p (MIRT004015)
- hsa-mir-375 (MIRT019882)
- hsa-mir-215-5p (MIRT024365)
- hsa-mir-192-5p (MIRT026513)
- hsa-mir-9-3p (MIRT035520)
- hsa-mir-769-5p (MIRT039178)
- hsa-mir-186-5p (MIRT044978)
- hsa-mir-25-3p (MIRT050264)
- hsa-mir-134-5p (MIRT054591)
- hsa-mir-130b-3p (MIRT054592)
- hsa-mir-29b-3p (MIRT438919)
- hsa-mir-218-5p (MIRT440422)
- hsa-mir-183-3p (MIRT562097)
- hsa-mir-223-3p (MIRT562098)
- hsa-mir-4697-3p (MIRT562099)
- hsa-mir-3622b-5p (MIRT562100)
- hsa-mir-5588-5p (MIRT562101)
- hsa-mir-4799-3p (MIRT562102)
- hsa-mir-4720-5p (MIRT562103)
- hsa-mir-8073 (MIRT562104)
- hsa-mir-221-5p (MIRT562105)
- hsa-mir-4292 (MIRT562106)
- hsa-mir-6791-5p (MIRT562107)
- hsa-mir-4308 (MIRT562108)
- hsa-mir-1910-5p (MIRT562109)
- hsa-mir-2114-5p (MIRT562110)
- hsa-mir-3529-3p (MIRT562111)
- hsa-mir-455-3p (MIRT562112)
- hsa-mir-4452 (MIRT567105)
- hsa-mir-6126 (MIRT567106)
- hsa-mir-4493 (MIRT567107)
- hsa-mir-605-3p (MIRT567108)
- hsa-mir-4521 (MIRT567109)
- hsa-mir-3910 (MIRT567110)
- hsa-mir-548at-5p (MIRT567111)
- hsa-mir-4796-3p (MIRT567112)
- hsa-mir-93-5p (MIRT567113)
- hsa-mir-526b-3p (MIRT567114)
- hsa-mir-519d-3p (MIRT567115)
- hsa-mir-20b-5p (MIRT567116)
- hsa-mir-20a-5p (MIRT567117)
- hsa-mir-17-5p (MIRT567118)
- hsa-mir-106b-5p (MIRT567119)
- hsa-mir-106a-5p (MIRT567120)
- hsa-mir-548ah-5p (MIRT567121)
- hsa-mir-3609 (MIRT567122)
- hsa-mir-548t-5p (MIRT567123)
- hsa-mir-548az-5p (MIRT567124)
- hsa-mir-548n (MIRT567125)
miRNA Products
- Search ViGene Biosciences for ITGB1
- SwitchGear ITGB1 3' UTR sequence
- SwitchGear ITGB1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Clone Products
- Sino Biological Human cDNA Clone for ITGB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ITGB1
- VectorBuilder custom plasmid, inducible vectors for ITGB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)
Cell Line Products
-
Horizon Cell Lines for ITGB1
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11977) for ITGB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB1 Gene
Localization for ITGB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGB1 Gene
- Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269 PubMed:10455171, ECO:0000303 PubMed:10455171}.
- Isoform 5: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IEA,TAS | 11919189 |
| GO:0005737 | cytoplasm | IDA | 16803572 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | NAS,TAS | -- |
| GO:0005913 | cell-cell adherens junction | IDA | 25468996 |
Pathways & Interactions for ITGB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
|
.38
.38
.38
.38
.38
|
| 2 | AKT Signaling Pathway | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 4 | ERK Signaling |
.61
.58
|
.49
|
| 5 | Integrin Pathway |
.67
.67
.56
|
.56
|
Pathways by source for ITGB1 Gene
17 Sino Biological pathways for ITGB1 Gene
3 Cell Signaling Technology pathways for ITGB1 Gene
24 BioSystems pathways for ITGB1 Gene
33 Reactome pathways for ITGB1 Gene
14 GeneGo (Thomson Reuters) pathways for ITGB1 Gene
8 R&D Systems pathways for ITGB1 Gene
- Articular Cartilage Extracellular Matrix Pathway
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier Pathway: Anatomy
2 Tocris pathways for ITGB1 Gene
Interacting Proteins for ITGB1 Gene
Selected Interacting proteins:
P05556-ITB1_HUMAN
ENSP00000303351
for ITGB1 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001708 | cell fate specification | IEA | -- |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IEA | -- |
| GO:0006968 | cellular defense response | TAS | 10201960 |
Drugs & Compounds for ITGB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Anti-thymocyte Globulin (Rabbit) | Approved | Pharma | Target | 0 | ||
| ATL1102 | Investigational | Pharma | antisense | 0 | ||
| R1295 | Investigational | Pharma | antagonist | 0 | ||
| Firategrast | Pharma | antagonist | α4β1/α4β7 integrin antagonist | 0 | ||
| BIO 1211 | Pharma | α4β1 inhibitor,selective and high affinity, Selective alpha4beta1 (VLA-4) inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| BTT 3033 |
|
1259028-99-3 |
|
|
(5) Tocris Compounds for ITGB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BIO 1211 | Selective alpha4beta1 (VLA-4) inhibitor | 187735-94-0 |
| BTT 3033 | Selective inhibitor of integrin alpha2beta1 | 1259028-99-3 |
| Cilengitide | Potent and selective inhibitor of integrins alphavbeta3 and alphavbeta5 | 188968-51-6 |
| Obtustatin | Potent and selective alpha1beta1 inhibitor | |
| TC-I 15 | Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo | 916734-43-5 |
(15) ApexBio Compounds for ITGB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BIO 1211 | α4β1 inhibitor,selective and high affinity | 187735-94-0 |
| BIO 5192 | Integrin α4β1 inhibitor | 327613-57-0 |
| CWHM-12 | 1564286-55-0 | |
| Echistatin, α1 isoform | 154303-05-6 | |
| Firategrast | α4β1/α4β7 integrin antagonist | 402567-16-2 |
| GR 144053 trihydrochloride | 1215333-48-4 | |
| LDV FITC | 1207610-07-8 | |
| Obtustatin | ||
| P11 | 848644-86-0 | |
| RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
| RGDS peptide | 91037-65-9 | |
| TC-I 15 | 916734-43-5 | |
| TCS 2314 | 317353-73-4 | |
| TR-14035 | α4β7 and α4β1 integrins antagonist | 232271-19-1 |
| Zaurategrast | Integrin inhibitor | 455264-31-0 |
Drug Products
- ApexBio compounds for ITGB1
Transcripts for ITGB1 Gene
mRNA/cDNA for ITGB1 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (1076) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGB1
- GenScript: Design CRISPR guide RNA sequences for ITGB1
miRNA Products
- Search ViGene Biosciences for ITGB1
- SwitchGear ITGB1 3' UTR sequence
- SwitchGear ITGB1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Clone Products
- Sino Biological Human cDNA Clone for ITGB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ITGB1
- VectorBuilder custom plasmid, inducible vectors for ITGB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11977) for ITGB1
Expression for ITGB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Cord Blood
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Mesenchymal Stem Cells Whartons Jelly
-
Epithelial Cells
- Fetal Matrix Cells Hair Follicle
- Anterior Lens Epithelial Cells Lens
- Limbal Basal Epithelial Cells Limbus Epithelium
- Inner Enamel Epithelial Cells Dental Enamel
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Umbilical Cord (Extraembryonic Tissues)
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Anterior Neck Muscles
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Trunk Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Lumbar Vertebrae Column Muscles
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
- Bone (Muscoskeletal System)
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Visceral White Preadipocytes Visceral White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Adipose-derived stem cells (Adipoplus)
- Adipose-derived stem cells
-
Hair (Integumentary System)
- Fetal Matrix Cells Hair Follicle
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
- Hair follicle stem cells
- Epidermal keratinocytes (EpiDex)
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Placenta-derived mesenchymal stem cells (family)
- Decidua-derived mesenchymal stem cells
- Decidua-derived mesenchymal cells
-
Eye (Sensory Organs)
- Anterior Lens Epithelial Cells Lens
- Limbal Basal Epithelial Cells Limbus Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
- Blood (Hematopoietic System)
-
Limb (Muscoskeletal System)
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Interzone Cells Autopod Synovial Joint
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
- Brain (Nervous System)
- NULL (Uncategorized)
-
Amnion (Extraembryonic Tissues)
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Mesenchymal Stem Cells Amniotic Fluid
- Amniotic Epithelial Cells Amniotic Membrane
- Amnion-derived mesenchymal stem cells
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Interzone Cells Autopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Zeugopod Synovial Joint
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Glial Cells
- Bergmann Glia Purkinje Cell Layer
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Spermatogonial Stem Cells Seminiferous Tubules
- Sertoli cells Seminiferous Tubules
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Hepatoblasts Liver Bud
- Fetal liver cells
- Epidermis (Integumentary System)
- Kidney (Urinary System)
- Heart (Cardiovascular System)
-
Somite (Muscoskeletal System)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Pancreas (Endocrine System)
- Mature Beta Cells Islets of Langerhans
- Islets of Langerhans
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Dopaminergic neuron-like cells (Sundberg M et. al. 2013)
- Neural Crest (Gastrulation Derivatives)
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
-
Gonad
- Spermatogonial Stem Cells Seminiferous Tubules
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Uterus (Reproductive System)
- Oral Cavity (Gastrointestinal Tract)
- Dopaminergic Neurons (Nervous System)
- Smooth Muscle (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ITGB1 Gene
This gene is overexpressed in Artery - Aorta (x4.1).
This gene is overexpressed in Amniocyte (7.7) and Seminal vesicle (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ITGB1 Gene:
ITGB1SOURCE GeneReport for Unigene cluster for ITGB1 Gene:
Hs.643813mRNA Expression by UniProt/SwissProt for ITGB1 Gene:
P05556-ITB1_HUMAN
Tissue specificity:
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
Primer Products
-
OriGene qPCR primer pairs for ITGB1
-
OriGene qPCR primer pairs and template standards for ITGB1
Orthologs for ITGB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGB1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ITGB1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ITGB1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ITGB1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Itgb1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itgb1 34 |
|
||
| chicken (Gallus gallus) |
Aves | ITGB1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ITGB1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | itgb1 34 |
|
||
| MGC76178 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7623 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | itgb1b 35 |
|
OneToMany | |
| itgb1a 34 35 |
|
||||
| itgb1b.1 35 |
|
OneToMany | |||
| itgb1b.2 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | mys 36 34 35 |
|
||
| bgrInt-ngr 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | INTB 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pat-3 36 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.871 35 |
|
OneToMany |
- Species where no ortholog for ITGB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ITGB1 Gene
Paralogs for ITGB1 Gene
(6) SIMAP similar genes for ITGB1 Gene using alignment to 14 proteins:
Pseudogenes.org Pseudogenes for ITGB1 Gene
Variants for ITGB1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1009002 | -- | 32,947,973(-) | TACGT(C/T)GTTAT | intron-variant | |
| rs1049433 | -- | 32,900,536(-) | TGTAT(A/G)TTTAC | utr-variant-3-prime | |
| rs10508776 | -- | 32,900,099(+) | ACTAA(C/T)GGCTC | downstream-variant-500B | |
| rs10586245 | -- | 32,908,763(+) | AATAT(-/AA)GTTTT | intron-variant | |
| rs10622276 | -- | 32,953,555(+) | AAAAA(-/AA)GTTGC | intron-variant |
Residual Variation Intolerance Score:
12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.99% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ITGB1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB1 Gene
Disorders for ITGB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral hypoxia |
|
|
| hydrocele |
|
|
| pustulosis palmaris et plantaris |
|
|
| mast cell disease |
|
|
| mast-cell leukemia |
|
|
Search ITGB1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ITGB1
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB1 Gene
Publications for ITGB1 Gene
- Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. (PMID: 23317506) Liu W. … Boggon T.J. (Mol. Cell 2013) 3 4 64
- Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M. … Takagi J. (J. Cell Biol. 2012) 3 4 64
- Integrins I+vI^3 and I+4I^1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. (PMID: 23125415) Fujita M. … Takada Y. (J. Immunol. 2012) 3 4 64
- Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. (PMID: 21325030) Qu H. … Wu C. (J. Cell Sci. 2011) 3 4 64
- ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin I^1 recycling in cell migration. (PMID: 22027826) Yu X. … Yao X. (J. Biol. Chem. 2011) 3 4 64
Products for ITGB1 Gene
- R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGB1 (Integrin beta 1/CD29)
- R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ITGB1
- AM06734PU-N
- AM06735PU-N
- AM09002PU-N
- AM09002PU-S
- AM31183AF-N
- AM31183FC-N
- AM31183PU-N
- AM31183PU-S
- AM31183RP-N
- AM32088PU-N
- AM32089PU-N
- AM32361PU-N
- AP06431PU-N
- AP20348PU-N
- AP55700PU-N
- AP55700PU-S
- AP55840PU-N
- AP55840PU-S
- BM2540
- BM6028P
- BM6029P
- SM1578F
- SM1578FT
- SM1578P
- SM1578PS
- SM1578PT
- SM1740P
- SM1740PT
- SM2118P
- SM2210B
- SM2210F
- SM2210FT
- SM2210FX
- SM2210LE
- SM2210P
- SM2210PS
- SM2210PT
- SM3016APC
- SM3016B
- SM3016F
- SM3016P
- SM3016R
- TA311968
- TA311969
- TA311970
- TA311971
- TA320392
- TA320393
- TA320394
- TA328165
- TA341143
- TA341149
- TA347998
- TA349358
- TA352316
- TA352317
- TA352640
- TA352676
- TA353268
- TA353269
- TA353270
- TA806909
- CF806909
- TA807138
- CF807138
- Custom Assay ServicesOriGene ELISA Kits for ITGB1
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- OriGene qPCR primer pairs and template standards for ITGB1
- OriGene qPCR primer pairs for ITGB1
- OriGene CRISPR knockouts for ITGB1
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- GenScript: Design CRISPR guide RNA sequences for ITGB1
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