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ITGB1 Gene

protein-coding   GIFtS: 68

GC10M033229
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FNRB, MSK12, MDF2)
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Aliases &
Descriptions
for ITGB1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CD29 1, 2
FNRB 2, 3, 5
GPIIA 1, 2
MDF2 2, 3
MSK12 2, 3
OTTHUMP00000019420 2
OTTHUMP00000046253 2
OTTHUMP00000063731 2
OTTHUMP00000063732 2
OTTHUMP00000063733 2
VLA-BETA 2
VLAB 2
Descriptions
CD29 antigen 3
Fibronectin receptor subunit beta 3
Integrin VLA-4 subunit beta 3
fibronectin receptor beta subunit 2
integrin VLA-4 beta subunit 2
integrin beta 1 2
integrin, beta 1 (fibronectin receptor, beta polypeptide,
antigen CD29 includes MDF2, MSK12) 2
External Ids
HGNC: 61531
Entrez Gene: 36882
UniProtKB: P055563
Ensembl: ENSG000001500937
Search outside databases for aliases for ITGB1 gene

Previous GC identifers: GC10M032936 GC10M033339 GC10M033193 GC10M033164

Summaries
for ITGB1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ITGB1:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8
beta subunits have been described in mammals. Integrin family members are membrane receptors
involved in cell adhesion and recognition in a variety of processes including embryogenesis,
hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene
encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different
protein isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are
receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the
proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1,
alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and
alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within
the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a
receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and
alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It
recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1,
cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin
alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate
with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a
receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of
ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect
on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with
extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When
associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation
of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1,
serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during
telophase, required for the successful completion of cytokinesis

Gene Wiki entry for ITGB1 (CD29)

Genomic Location
for ITGB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ITGB1 gene  

Entrez Gene cytogenetic band: 10p11.2   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.2

ITGB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M033229:     (about GC identifiers)

Start:
 33,229,326 bp from pter
End:
 33,287,204 bp from pter
Size:
 57,879 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  

Proteins
for ITGB1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 (See protein sequence)
Recommended Name: Integrin beta-1 precursor  
Size: 798 amino acids; 88415 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1,
alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or
alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5.
Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A
interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and
SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a
receptor for these viruses. Interacts with RAB21
Subcellular location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform
beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on
plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and
metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early
telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated
to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase,
concentrated to the extending protrusions formed at the opposite ends of the spreading daughter
cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells
PDB structure from and Proteopedia :
1K11 (3D)    1LHA (3D)    
Secondary accessions: A8K6N2 P78466 P78467 Q13089 Q13090 Q13091 Q13212 Q14622 Q14647 Q29RW2 Q7Z3V1
Q8WUM6
Alternative splicing: 5 isoforms:  P05556-1   P05556-2   P05556-3   P05556-4   P05556-5   

Post-translational modifications:

  • The cysteine residues are involved in intrachain disulfide bonds (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (6 alternative transcripts): 
    NP_002202.2  NP_389647.1  NP_391987.1  NP_391988.1  NP_391989.1  NP_596867.1  


    ENSEMBL proteins: 
    ENSP00000364094 ENSP00000302683 ENSP00000352630 ENSP00000384687 ENSP00000303351 ENSP00000379350 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ITGB1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Integrin alpha 4 + beta 1, Integrin alpha 6+beta 1, Integrin alpha 1 + beta 1, Integrin alpha 3+beta 1, Integrin beta 1, Integrin alpha 9+beta 1 , Integrin alpha 5 + beta 1, Integrin beta 1d, Integrin alpha 2+beta 1)
    Human Recombinant Proteins from Abnova (ITGB1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005925colocalizes with focal adhesion IDA14970227
    GO:0008305 integrin complex NAS9552005
    GO:0009986 cell surface IDA1715889
    GO:0016021 integral to membrane IEA--
    GO:0019717 synaptosome IEA--
    About this table

    Antibodies for ITGB1: 
    Invitrogen Antibodies for ITGB1
    Millipore Mono- and Polyclonal Antibodies for the study of ITGB1
    Sigma-Aldrich Antibodies for ITGB1
    R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
    Cell Signaling Technology (CST) Antibodies for ITGB1 (Integrin Beta1, Integrin _1)
    Antibodies from Abcam (Integrin alpha 4 + beta 1, Integrin alpha 6+beta 1, Integrin alpha 1 + beta 1, Integrin alpha 3+beta 1, Integrin alpha 9+beta 1 , Integrin beta 1, Integrin alpha 5 + beta 1, Integrin alpha 2+beta 1, Integrin beta 1d), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ITGB1)
    Novus Biologicals Antibodies for ITGB1

    Assays for ITGB1: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of ITGB1
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ITGB1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/11 InterPro domains/families (see all 11 ):
     IPR003659 Plexin-like
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR013032 EGF-like_reg_CS
     IPR001169 Integrin_bsu_C


       GeneDecks  ITGB1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P05556

    ProtoNet protein and cluster: P05556

    2 Blocks protein families:
    IPB001169 Integrin beta
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain

    Gene Function
    for ITGB1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ITGB1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ITGB1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_002211

                  Applied Biosystems Silencer® siRNAs for ITGB1

                  Sigma-Aldrich siRNA and siRNA Panels for ITGB1  
                         Sigma-Aldrich shRNA Panels and shRNA for ITGB1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ITGB1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_002211
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_002211
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_002211 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_033667

    UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
    Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are
    receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the
    proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1,
    alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and
    alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within
    the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a
    receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and
    alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It
    recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1,
    cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin
    alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate
    with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a
    receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of
    ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect
    on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with
    extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When
    associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
    Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation
    of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1,
    serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during
    telophase, required for the successful completion of cytokinesis

    Genatlas biochemistry entry for ITGB1:
    integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and
    fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal
    antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular
    matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and
    various signaling molecules within cells,inducing an alternatively spliced isoform
    ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer
    (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of
    terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle
    inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes

    15/27 MGI mutant phenotypes (inferred from 15 alleles) (MGI details for Itgb1) (see all 27 ):

    behavior/neurologicalcellularcraniofacialdigestive/alimentary
    embryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/earhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aging

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005178 integrin binding IEA--
    GO:0042802 identical protein binding IPI14681217
    GO:0046982 protein heterodimerization activity NAS9552005
    About this table

    Pathways & Interactions
    for ITGB1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/14 Invitrogen iPath™ Online BioAtlas - Pathways for ITGB1 (see all 14 ) (Maps provided by GeneGo):
     Integrin-mediated cell-matrix adhesion
     Putative integrins pathway. Part 2
     PTEN pathway
     Pleckstrin homology proteins interactions. Part VIII
     The role of amyloid proteins in cell adhesion

       GeneDecks  ITGB1 for the pathways selected above  
    About GeneDecksing

    5/14 Millipore Pathways for ITGB1 (see all 14 )
     Cytoskeleton remodeling Integrin outside-in signaling
     Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
     Signal transduction PTEN pathway
     Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
     Cell adhesion PLAU signaling

       GeneDecks  ITGB1 for the pathways selected above  
    About GeneDecksing

    5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for  ITGB1  (Your Favorite Gene powered by Ingenuity) (see all 20 ) 
     Germ Cell-Sertoli Cell Junction Signaling
     CDK5 Signaling
     PTEN Signaling
     Agrin Interactions at Neuromuscular Junction
     Clathrin-mediated Endocytosis

       GeneDecks  ITGB1 for the pathways selected above  
    About GeneDecksing

    5/10 Kegg Pathways  (Kegg details for ITGB1) (see all 10 ):
     hsa04360 Axon guidance
     hsa04510 Focal adhesion
     hsa04512 ECM-receptor interaction
     hsa04514 Cell adhesion molecules (CAMs)
     hsa04670 Leukocyte transendothelial migration

       GeneDecks  ITGB1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ITGB1 


    5/312 Interacting proteins for ITGB1 (P055561, 2 ENSP000003640943) via UniProtKB, MINT, and/or STRING (see all 312 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNAP213332, ENSP000003588793MINT-51379 MINT-5226973 MINT-5227032 STRING (score=.997)
    CD63P089622, ENSP000002578573MINT-2981958 MINT-2981939 STRING (score=.995)
    FHL2Q141922, ENSP000003442663MINT-16547 MINT-16546 STRING (score=.77)
    ITGB1P055561EBI-703066, EBI-703066
    ANKS1BQ7Z6G82MINT-45910
    About this table

    5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082 G1/S transition of mitotic cell cycle IEA--
    GO:0001701 in utero embryonic development IEA--
    GO:0006968 cellular defense response TAS10201960
    GO:0007155 cell adhesion IEA--
    GO:0007156 homophilic cell adhesion TAS10201960
    About this table

    Drugs & Compounds
    for ITGB1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ITGB1
    10/44 Novoseek chemical compound relationships for ITGB1 gene (see all 44 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    grgdsp 65.92 1 7648723 (1)
    kalinin 64.32 1 8876604 (1)
    tyrosine 49.50 52 11250890 (3), 7520449 (3), 7592610 (2), 10395641 (2) (see all 37)
    matrigel 44.25 2 8740459 (2)
    cytochalasin b 36.85 2 14706635 (1), 8989906 (1)
    phosphotyrosine 36.09 5 7577832 (1), 7527397 (1), 8546227 (1), 8748369 (1) (see all 5)
    slex 36.08 2 9733622 (1), 18334960 (1)
    wortmannin 25.61 6 8557753 (2), 15546505 (1), 12209735 (1), 8526858 (1)
    manganese 21.18 8 7526892 (3), 7592728 (2), 8534485 (2), 9762467 (1)
    tripeptide 18.41 1 7630002 (1)
    About this table


    Transcripts
    for ITGB1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ITGB1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ITGB1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_002211

                  Sigma-Aldrich siRNA and siRNA Panels for ITGB1  
                         Sigma-Aldrich shRNA Panels and shRNA for ITGB1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002211  NM_033666  NM_033667  NM_033668  NM_033669  NM_133376  

    REFSEQ mRNAs for ITGB1 gene (6 alternative transcripts): 

    NM_002211.3   NM_033666.2   NM_033667.2   NM_033668.2   NM_033669.2   NM_133376.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002211  NM_033666  NM_033667  NM_033668  NM_033669  NM_133376  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_002211
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_002211
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_002211 

    Additional cDNA sequence: 

    AF086249.1 AK291697.1 BC020057.1 BC113901.1 BX537407.1 CR618169.1 M34189.1 U28252.1 

    24/45 DOTS entries (see all 45 ):

    DT.95144425  DT.95250205  DT.100889329  DT.92468841  DT.102839004  DT.92411211  DT.65286518  DT.100659208 
    DT.100889330  DT.92468837  DT.100889338  DT.100889328  DT.121292288  DT.100889349  DT.121292242  DT.100045345 
    DT.100889343  DT.121292182  DT.95172289  DT.95129453  DT.97820426  DT.100889347  DT.121292178  DT.121292202 

    24/1076 AceView cDNA sequences (see all 1076 ):

    AW304321 BE925988 AI452617 AA363458 BG165217 AI755271 AW295975 AL701790 
    AI281485 BX425120 AW166647 AI470664 AL710877 W39486 AI567046 AU131214 
    BX952322 BU623410 AA172376 BU542455 BU145712 BM752439 BQ773452 BM564553 

    highest scoring ESTs for ITGB1:

    AA315894 AL708823 AL709083 AL710294 AL710827 AL710862 AL710868 AL710873 AL710877 AL710893 

    Unigene Cluster for ITGB1:

    Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    Hs.643813  [show with all ESTs]
    Unigene Representative Sequence: NM_002211


    GeneLoc Exon Structure

    6 Ensembl transcripts including schematic representations:
    ENST00000374956  ENST00000302252  ENST00000359614  ENST00000401956  ENST00000302278  ENST00000396033  

    Expression
    for ITGB1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ITGB1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ITGB1

    1 / 2 / 3

    12 probe-sets matching ITGB1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		2055_s_at2, 3 U95-A 1 1.00 1.00 0.59 0.33 M34189 0.80 1.00 0.91 1

    		32808_at2, 3 U95-A 1 1.00 1.00 0.77 1.30 X07979 0.80 1.00 0.91 1

    		74589_at2, 3 U95-D 1 0.81 1.00 0.92 1.38 AI926538 0.40 1.00 0.76 1

    		211945_s_at2, 3 U133-A 1 1.00 1.00 -- -- BG500301 0.40 1.00 0.76 1

    		216178_x_at2, 3 U133-A 1 1.00 1.00 -- -- AA215854 0.40 1.00 0.76 1

    		215878_at2, 3 U133-A 1 0.46 1.00 -- -- BG435463 0.60 1.00 0.82 1

    		1553530_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		211945_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1561042_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1553678_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		216178_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		215878_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGAAGTTATA

    SOURCE GeneReport for Unigene cluster: Hs.643813

    Expression variation in blood from EXPOLDB for ITGB1

    UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
    Tissue specificity: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed
    with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle,
    cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells,
    hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in
    muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast
    cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather
    than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed
    in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the
    surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is
    expressed specifically in striated muscle (skeletal and cardiac muscle)

    Orthologs
    for ITGB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ITGB1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ITGB11   -- integrin, beta 1 (fibronectin receptor, beta polypeptide, more 92.59(n)
    95.26(a)    		 477956  XM_535143.2  XP_535143.2 
    chimpanzee
    (Pan troglodytes)    		 ITGB11   -- integrin, beta 1 (fibronectin receptor, beta polypeptide, more 98.75(n)
    98.37(a)    		 450396  XM_507735.2  XP_507735.2 
    cow
    (Bos taurus)    		 ITGB11   -- integrin, beta 1 (fibronectin receptor, beta polypeptide, more 89.56(n)
    92.98(a)    		 281876  NM_174368.2  NP_776793.1 
    rat
    (Rattus norvegicus)    		 Itgb11   -- integrin beta 1 (fibronectin receptor beta) 86.17(n)
    90.6(a)    		 24511  NM_017022.1  NP_058718.1 
    mouse
    (Mus musculus)    		 Itgb11, 5 85
    		 integrin beta 1 (fibronectin receptor beta)1, 5 86.88(n)1
    91.23(a)1    		 164121  NM_010578.11  NP_034708.11 
     AA4099755  AA9601595  (see all 26)
    About this table        Species with no ortholog for ITGB1

    ENSEMBL Gene Tree for ITGB1

    Paralogs
    for ITGB1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ITGB1 gene
    ITGB72  ITGB22  

    SNPs/Variants
    for ITGB1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/322 NCBI SNPs in ITGB1 are shown (see all 322 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 127)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs25040011,2
    		A,C,F,H,O33264893(+) AGACCA/GGCATA 6 -- ng31 int17Minor allele frequency- G:0.34NA EU EA WA 552
    --
    rs174681,2
    		A,C,F,H,O33230291(-) GGTTAT/CTCTTG 5 -- ut313Minor allele frequency- C:0.25EA MN EU 1574
    rs11870781,2
    		A,C,F,H33289139(+) ACACTG/ACAACT 1 -- ng3112Minor allele frequency- A:0.33EU EA WA NA 1198
    rs25040171,2
    		A,C,F,O33228897(+) GTAGTA/TCTTAT 1 -- ng513Minor allele frequency- T:0.39NA 138
    rs24883151,2
    		A,C,F,O33229095(+) CCAGCG/ATAGCA 1 -- ng514Minor allele frequency- A:0.41EA NA 214
    rs13167571,2
    		C,F,H,O33237203(+) TTAGAA/CAGGAC 6 -- int1 ut319Minor allele frequency- C:0.32EA NA MN EU WA 1966
    --
    rs38246021,2
    		A,C,F,H33235883(-) ATATCG/ACTATT 6 -- ng51 int14Minor allele frequency- A:0.26EU EA WA 412
    rs22458441,2
    		A,C,F,H33264782(+) GCGCTC/AAAAAA 6 -- int1 ng314Minor allele frequency- A:0.19EU EA WA 412
    rs22458401,2
    		A,C,F,H33264662(+) CCCTAG/TCTGGT 6 -- int1 ng314Minor allele frequency- T:0.25EU EA WA 388
    rs105087761,2
    		C,F,H33229033(+) ACTAAT/CGGCTC 1 -- ng5112Minor allele frequency- C:0.11NS EU EA WA NA 666
    About this table

    HapMap Linkage Disequilibrium images for ITGB1 (up to first 250kb)

    Disorders & Mutations
    for ITGB1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 135630

    10/82 Novoseek disease relationships for ITGB1 gene (see all 82 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 39.33 30 8630057 (3), 8006453 (3), 8694563 (3), 1293173 (2) (see all 16)
    tumors 36.47 67 7508107 (5), 11319874 (4), 7529636 (4), 7526040 (3) (see all 44)
    metastasis 32.53 13 14666731 (2), 1282908 (1), 9337541 (1), 1293172 (1) (see all 10)
    myeloma 28.31 11 7861616 (1), 18850009 (1), 9513075 (1), 7686332 (1) (see all 6)
    fibrosarcoma 26.67 1 11921440 (1)
    colon carcinoma 24.83 1 7509799 (1)
    necrosis 23.96 7 1723314 (1), 9348298 (1), 10417618 (1), 10235499 (1) (see all 6)
    osteosarcoma 23.93 4 8326445 (2), 8010959 (1), 7541624 (1)
    nephrotic syndrome minimal change 22.87 2 9355070 (1)
    plasma cell leukemia 21.91 1 7686332 (1)
    About this table

    Genetic Association Database: ITGB1
    Human Genome Epidemiology Navigator: ITGB1 (8 documents)

    Medical News
    for ITGB1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ITGB1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1085 PubMed articles for ITGB1 gene (see all 1085 ):

    Search for ITGB1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITGB1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3688 HGNC: 6153 AceView: ITGB1 Ensembl:ENSG00000150093 euGenes: HUgn3688
    ECgene: ITGB1 H-InvDB: ITGB1

    Other Databases showing ITGB1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ITGB1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ITGB1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD29

    Licensable Technologies
    for ITGB1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ITGB1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ITGB1:
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    		  Free SNP selection tool



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     Antibodies & Assays for ITGB1 (Integrin Beta1, Integrin _1)

     Recombinant Proteins
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     Antibodies for ITGB1

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