ITGB1 Gene protein-coding GIFtS : 70 GCID: GC10 M033189
Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide,... FNRB, MSK12, MDF2 )
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Aliasesfor ITGB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29Includes MDF2, MSK12) 1 2 VLAB2 FNRB1 2 3 5 Integrin Beta-12 MDF21 2 3 Integrin VLA-4 Beta Subunit2 MSK121 2 3 Very Late Activation Protein, Beta Polypeptide2 Glycoprotein IIa2 3 CD29 Antigen3 GPIIA2 3 Fibronectin Receptor Subunit Beta3 CD292 VLA-4 Subunit Beta3 VLA-BETA2
Export aliases for ITGB1 gene to outside databases Previous GC identifers: GC10M032936 GC10M033339 GC10M033193 GC10M033164 GC10M033229
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Summariesfor ITGB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ITGB1 Gene: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunitshave been described in mammals. Integrin family members are membrane receptors involved in cell adhesion andrecognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response andmetastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcriptvariants which encode different protein isoforms have been found for this gene. (provided by RefSeq, Jul 2008) GeneCards Summary for ITGB1 Gene: ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)) is a protein-coding gene. Diseases associated with ITGB1 include frozen shoulder cerebral hypoxia related super-pathways are Integrin-mediated cell adhesion and ECM-receptor interaction . GO annotations related to this gene include protein kinase binding and protein heterodimerization activity . An important paralog of this gene is ITGB4 . UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 Function : Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors forcollagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R incollagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1,alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes oneor more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 isa receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 arereceptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S inVCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequenceA-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrinalpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array ofligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesionand migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seemsto enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates celladhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis.Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly processand the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases suchas PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation orinactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion ofcytokinesis summary
for ITGB1 Gene: Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist asheterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated andcontain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cellattachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes withproteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focaladhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also havea significant role in cell signaling and can activate protein kinases involved in the regulation of cellgrowth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) isan integrin receptor found on the surface of platelets. It is involved in the cross-linking of plateletswith fibrin, and so has a vital role in blood clot formation. Gene Wiki entry for ITGB1 (CD29) Gene
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Genomic Viewsfor ITGB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NT_008705.16 NC_018921.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ITGB1 gene promoter:AP-1 ATF-2 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for ITGB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10p11.2 Ensembl cytogenetic band: 10p11.22 HGNC cytogenetic band: 10p11.2 ITGB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M033189: view genomic region
(about GC identifiers )
Start: 33,189,246 bp from pter End:
33,294,720 bp from pter
Size: 105,475 bases Orientation:
minus strand
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Proteinsfor ITGB1 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 See
protein sequence )Recommended Name: Size : 798 amino acids; 88415 DaSubunit : Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3,alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and NMRK2,when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK (By similarity). Interacts (viathe cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interactswith KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsidproteins and acts as a receptor for these viruses. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1Dinteracts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with MYO10.Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts withITGB1BP1 (via C-terminus region); the interaction is a prerequisite for focal adhesion disassembly. Interactswith TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with humancytomegalovirus/HHV-5 envelop glycoprotein B/gB
Subcellular location : Cell membrane; Single-pass type I membrane protein. Melanosome. Cleavage furrow. Cellprojection, lamellipodium. Cell projection, ruffle. Note=Isoform beta-1B does not localize to focal adhesions.Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancercell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellularvesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase,concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase,concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, invesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 andmetastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages ofcell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillaradhesions in a ITGB1BP1-dependent manner
Sequence caution : Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;6/7 PDB 3D structures from (see all 7 ):1K11 (3D) 1LHA (3D) 3G9W (3D) 3T9K (3D) 3VI3 (3D) 3VI4 (3D) Secondary accessions : A8K6N2 D3DRX9 D3DRY3 D3DRY4 D3DRY5 P78466 P78467 Q13089 Q13090 Q13091Q13212 Q14622 Q14647 Q29RW2 Q7Z3V1 Q8WUM6 Alternative splicing : 5 isoforms : P05556-1 P05556-2 P05556-3 P05556-4 P05556-5 Explore the universe of human proteins at neXtProt for ITGB1: NX_P05556 Explore proteomics data for ITGB1 at MOPED Post-translational modifications:
UniProtKB: The cysteine residues are involved in intrachain disulfide bonds (By similarity) View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P05556 ITGB1 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (3 alternative transcripts): NP_002202.2 NP_391988.1 NP_596867.1 ENSEMBL proteins: ENSP00000303351 ENSP00000417508 ENSP00000417799 ENSP00000417537 ENSP00000420282 ENSP00000418725 ENSP00000431326 ENSP00000398029 ENSP00000417243 ENSP00000436214 ENSP00000404546 ENSP00000420792 ENSP00000420416 ENSP00000400544 ENSP00000379350 ENSP00000364094 ENSP00000388694 Reactome Protein details: P05556 Human Recombinant Protein Products for ITGB1: Gene Ontology (GO): 5/28 cellular component terms (GO ID links to tree view) (see all 28 ): About this table
About GeneDecksing ITGB1 Antibody Products: Assay Products for ITGB1:
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Protein
Domains /for ITGB1 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: CD: CD molecules ITG: Integrins 5/9 InterPro protein domains (see all 9 ):
Graphical View of Domain Structure for InterPro Entry P05556 ProtoNet protein and cluster: P05556
2 Blocks protein domains : IPB001169 IPB002369 UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 Similarity : Belongs to the integrin beta chain familySimilarity : Contains 1 VWFA domainAbout GeneDecksing
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Functionfor ITGB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ITB1_HUMAN, P05556 Function : Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors forcollagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R incollagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1,alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes oneor more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 isa receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 arereceptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S inVCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequenceA-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrinalpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array ofligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesionand migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seemsto enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates celladhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis.Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly processand the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases suchas PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation orinactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion ofcytokinesis
Genatlas biochemistry entry for ITGB1 integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 andfibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodiesA-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to othercells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules withincells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermalcells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasalmarkers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitorp27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19 ): About this table
About GeneDecksing Phenotypes: 5 GenomeRNAi human phenotypes for ITGB1 :15/27 MGI mutant phenotypes (inferred from 24 alleles(MGI details for Itgb1) (see all 27 ):About GeneDecksing Animal Models: MGI mouse knock-outs for ITGB1: Itgb1 tm1Son Itgb1 tm1Lscd Itgb1 tm2Ref Itgb1 tm1.1Efu Cell Line GenScript Custom overexpressing Cell Line Services for ITGB1 Search LifeMap BioReagents cell lines for ITGB1 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1
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Pathways & Interactionsfor ITGB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for ITGB1 About (see all 84 ) See pathways by source SuperPath Contained pathways About 1 Focal Adhesion 2 Non-integrin membrane-ECM interactions 3 Hypertrophic cardiomyopathy (HCM) 4 Development Slit-Robo signaling 5 Integrin Pathway
Pathways by source See SuperPaths Show all pathways 5/14 (see all 14 )1 5/38 (see all 38 )2 2 5/14 (see all 14 )5/22 (see all 22 )5/27 (see all 27 )5/20 (Kegg details for ITGB1) (see all 20 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/297 Interacting proteins for ITGB1 (P05556 1 , 2 , 3 ENSP00000364094 4 via UniProtKB, MINT, STRING , and/or I2D (see all 297 )Interactant Interaction Details GeneCard External ID(s) CD63 P08962 2 , 3 ENSP00000257857 4 MINT-2981958 MINT-2981939 MINT-8407185 I2D:
score=2 STRING: ENSP00000257857 FHL2 Q14192 2 , 3 ENSP00000322909 4 MINT-16547 MINT-16546 I2D:
score=4 STRING: ENSP00000322909 ITGA2 P17301 1 , 3 ENSP00000296585 4 EBI-703066,EBI-702960 I2D:
score=3 STRING: ENSP00000296585 CSF2RB P32927 1 , 3 ENSP00000384053 4 EBI-703066,EBI-1809771 I2D:
score=2 STRING: ENSP00000384053 FN1 P02751 2 , 3 ENSP00000346839 4 MINT-8208428 I2D:
score=2 STRING: ENSP00000346839
About this table Gene Ontology (GO): 5/55 biological process terms (GO ID links to tree view) (see all 55 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000082 G1/S transition of mitotic cell cycle
IEA -- GO:0001701 in utero embryonic development
IEA -- GO:0001708 cell fate specification
IEA -- GO:0001894 tissue homeostasis
IEA -- GO:0002042 cell migration involved in sprouting angiogenesis
IEA --
About GeneDecksing
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Drugs & Compoundsfor ITGB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for ITGB1 available from Tocris Bioscience About this table Compound Action
CAS
# TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5] BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0] Leukadherin 1 Allosteric activator of CD11b/CD18 [344897-95-6] A 286982 Potent inhibitor of the LFA-1/ICAM-1 interaction [280749-17-9] Obtustatin Potent and selective alpha1beta1 inhibitor --
1 DrugBank Compound for ITGB1 About this table 10/64 Novoseek inferred chemical compound relationships for ITGB1 gene (see all 64 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
grgdsp
65.5
1
7648723 (1)
kalinin
63.9
1
8876604 (1)
herbimycin a
57.6
4
15546505 (1), 8089188 (1), 9230816 (1), 12209735 (1)
tyrosine
48.7
52
11250890 (3), 7520449 (3), 7592610 (2), 10395641 (2) (see
all 37 )
matrigel
48.7
2
8740459 (2)
cytochalasin b
39.3
2
14706635 (1), 8989906 (1)
adapalene
38.9
1
19657615 (1), 19903100 (1)
phosphotyrosine
35.3
5
7577832 (1), 7527397 (1), 8546227 (1), 8748369 (1) (see
all 5 )
slex
35.1
2
9733622 (1), 18334960 (1)
genistein
30.5
2
11315093 (1), 8089188 (1)
ITGB1 / ITB1
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Transcriptsfor ITGB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ITGB1 gene (6 alternative transcripts): NM_002211.3 NM_033668.2 NM_133376.2 NM_033666.2 NM_033667.2 NM_033669.2 Unigene Cluster for ITGB1:
Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Hs.643813 [show with all ESTs ] Unigene Representative Sequence: NM_002211 18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20 ): ENST00000302278 ENST00000488427 ENST00000494395 ENST00000484088 ENST00000480226 ENST00000474568 ENST00000488494 ENST00000534049 ENST00000437302 ENST00000475184 ENST00000528877 ENST00000417122 ENST00000464001 ENST00000493758 ENST00000472147 ENST00000414670 ENST00000439974 ENST00000396033 (uc001iws.4 ) Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 Primer ITGB1 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AK291697.1 BC020057.1 BC113901.1 BX537407.1 M34189.1 U28252.1
24/46 DOTS entries (see all 46 ): DT.95250205 DT.95144425
DT.92411211 DT.100889329 DT.92468841 DT.65286518 DT.102839004 DT.100659208 DT.100889330 DT.92468837 DT.100889334 DT.100889338 DT.100889349 DT.100889328 DT.121292288 DT.100045345 DT.100889343 DT.121292182 DT.95172289 DT.95129453 DT.121292178 DT.97820426 DT.100889347 DT.121292202 24/1076 AceView cDNA sequences (see all 1076 ):
BX952322 BQ773452 AA984009 AA393858 AI597586 AU129980 BG568595 AL047242 CD722765 AA894385 CF552433 AI978938 BG055271 CD514801 CD516552 AV655409 AW471282 AL710873 AA136528 CR618169 CN483087 AL598172 AI753845 AA563900 GeneLoc Exon Structure
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Expression for ITGB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ITGB1 expression in normal human tissues
(normalized intensities) ITGB1 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TGAAGTTATAAbout this image
ITGB1 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/53 selected tissues (see all 53 ) fully expand See ITGB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ITGB1 SOURCE GeneReport for Unigene cluster: Hs.643813 UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 Tissue specificity : Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a morerestricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta,umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells.Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium,umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood celllines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoformbeta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, onthe surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressedspecifically in striated muscle (skeletal and cardiac muscle) SABiosciences Expression via Pathway-Focused PCR Arrays including ITGB1 (see all 15 ): Primer ITGB1 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1
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Orthologsfor ITGB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ITGB1 gene from 7/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Itgb11 5
integrin beta 1 (fibronectin receptor beta)1, 5
86.84(n) 1 91.23(a) 1
8 (76.09 cM) 5 16412 1 NM_010578.2 1 NP_034708.1 1 128685654 5
chicken Aves ITGB11
integrin, beta 1 (fibronectin receptor, beta polypeptide, more
78.04(n) 83.88(a)
374058 NM_001039254.2 NP_001034343.2
lizard Reptilia ITGB16
integrin, beta 1 (fibronectin receptor, beta polyp... 79(a)
1 ↔ 1
6(12274686-12325701)
African clawed frog Amphibia Xl.76232
X.laevis integrin beta-1* subunit mRNA, complete cds
78.8(n)
M20180.1
zebrafish Actinopterygii itgb1a1
integrin, beta 1a
68.55(n) 77.04(a)
556734 NM_001034971.1 NP_001030143.1
fruit fly Insecta mys1 3
central nervous system developmentmore 3 1
42(a) 3 51.05(n) 1 47.38(a) 1
44885 1 NM_080054.2 1 NP_524793.2 1
worm Secernentea pat-31 3
beta integrin3 1
41(a) 3 52.25(n) 1 43.24(a) 1
III(3981133-3985933)3 175504 1 NM_065386.4 1 NP_497787.1 1
ENSEMBL Gene Tree for ITGB1 (if available)TreeFam Gene Tree for ITGB1 (if available)
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Paralogsfor ITGB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ITGB1 gene ITGB4 2 ENSG00000259753 2 ITGB7 2 ITGB2 2 ITGBL1 2 ITGB3 2 ITGB8 2 ITGB6 2 ITGB5 2 6 SIMAP similar genes for ITGB1 using alignment to 14 protein entries: ITB1_HUMAN (see all proteins ):ITGB5 ITGB8 ITGB3 ITGB7 ITGB2 ITGB6 About GeneDecksing 1 Pseudogenes.org Pseudogene for ITGB1 PGOHUM00000234172
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Genomic Variantsfor ITGB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 10 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ITGB1 (33189246 - 33294720 bp)
Structural Variations Database of Genomic Variants (DGV) 3 variations for ITGB1 : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ITGB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 135630
OMIM disorders : --20/144 (see all 144 ): About MalaCards frozen shoulder cerebral hypoxia sipple syndrome plasma cell leukemia blood clots bullous keratopathy hemorrhagic fever with renal syndrome keratopathy oral leukoplakia glanders von willebrand's disease fraser syndrome leukoplakia focal segmental glomerulosclerosis synovitis adenomyosis teratocarcinoma bullous pemphigoid benign tumors prostate adenocarcinoma 1 disease from the University of Copenhagen DISEASES database for ITGB1 :Cancer About GeneDecksing Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/81 Novoseek inferred disease relationships for ITGB1 gene (see all 81 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma
38.7
30
8630057 (3), 8006453 (3), 8694563 (3), 1293173 (2) (see
all 16 )
tumors
38.3
71
7508107 (5), 11319874 (4), 7529636 (4), 7526040 (3) (see
all 47 )
metastasis
34
15
14666731 (2), 1282908 (1), 9337541 (1), 1293172 (1) (see
all 12 )
myeloma
27.1
11
7861616 (1), 18850009 (1), 9513075 (1), 7686332 (1) (see
all 6 )
fibrosarcoma
25.6
1
11921440 (1)
colon carcinoma
23.7
1
7509799 (1)
necrosis
23.2
7
1723314 (1), 9348298 (1), 10417618 (1), 10235499 (1) (see
all 6 )
osteosarcoma
22.5
4
8326445 (2), 8010959 (1), 7541624 (1)
nephrotic syndrome minimal change
21.9
2
9355070 (1)
plasma cell leukemia
20.6
1
7686332 (1)
Genetic Association Database (GAD): ITGB1 Human Genome Epidemiology (HuGE) Navigator: ITGB1 (18 documents) Export disorders for ITGB1 gene to outside databases
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Publicationsfor ITGB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ITGB1 gene, integrated from 9 sources (see all 1475 ):(articles sorted by number of sources associating them with ITGB1) Utopia : connect your pdf to the dynamic
Crystal structure of a5b1 integrin ectodomain: atomic details of the fibronectin receptor. (PubMed id 22451694) 1 , 2 (2012) Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. (PubMed id 21325030) 1 , 2 (2011) Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624) 1 , 4(2010) The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. (PubMed id 20660204) 1 , 2 (2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 , 4(2010) Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444) 1 , 4(2010) Genome-wide association scan of trait depression. (PubMed id 20800221) 1 , 4(2010) KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674) 1 , 4(2009) Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. (PubMed id 18057877) 1 , 4(2008) Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571) 1 , 4(2008)
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External Searches for ITGB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ITGB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ITGB1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ITGB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ITGB1 gene: ITGB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ITGB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ITGB1
Tocris compounds for ITGB1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1
ThermoFisher Antibody for ITGB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITGB1
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