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ITGB1 Gene

protein-coding   GIFtS: 70
GCID: GC10M033189

Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide,...


(Previous symbols: FNRB, MSK12, MDF2)
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Aliases
for ITGB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29
Includes MDF2, MSK12)1 2
     VLAB2
FNRB1 2 3 5     Integrin Beta-12
MDF21 2 3     Integrin VLA-4 Beta Subunit2
MSK121 2 3     Very Late Activation Protein, Beta Polypeptide2
Glycoprotein IIa2 3     CD29 Antigen3
GPIIA2 3     Fibronectin Receptor Subunit Beta3
CD292     VLA-4 Subunit Beta3
VLA-BETA2     

External Ids:    HGNC: 61531   Entrez Gene: 36882   Ensembl: ENSG000001500937   OMIM: 1356305   UniProtKB: P055563   

Export aliases for ITGB1 gene to outside databases

Previous GC identifers: GC10M032936 GC10M033339 GC10M033193 GC10M033164 GC10M033229


Summaries
for ITGB1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGB1 Gene:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits
have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and
recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and
metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript
variants which encode different protein isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGB1 Gene:
ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)) is a protein-coding gene. Diseases associated with ITGB1 include sipple syndrome, and cerebral hypoxia. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity. An important paralog of this gene is ITGB4.

UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for
collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in
collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1,
alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one
or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is
a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are
receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in
VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.
Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin
alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of
ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and
migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to
enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell
adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis.
Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process
and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such
as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or
inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of
cytokinesis
Function: Isoform 5: Isoform 5 displaces isoform 1 in striated muscles (By similarity)

summary for ITGB1 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGB1 (CD29) Gene


Genomic Views
for ITGB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGB1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGB1 promoter sequence
   Search Chromatin IP Primers for ITGB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.2   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.2

ITGB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M033189:  view genomic region     (about GC identifiers)

Start:
 33,189,246 bp from pter      End:
 33,294,720 bp from pter
Size:
 105,475 bases      Orientation:
 minus strand

Proteins
for ITGB1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556 (See protein sequence)
Recommended Name: Integrin beta-1 precursor  
Size: 798 amino acids; 88415 Da
Subunit: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3,
alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and NMRK2,
when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic
region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the
presence of GNB2L1 and SRC. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial
cells adhesion by controlling AMICA1 homodimerization. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and
8 capsid proteins and acts as a receptor for these viruses. Interacts with FLNA, FLNB and RANBP9. Isoform 5
interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with
DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via
C-terminus region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the
interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus/HHV-5 envelope
glycoprotein B/gB. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts
with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult
heart
Sequence caution: Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for ITGB1 (see all 7):
1K11 (3D)        1LHA (3D)        3G9W (3D)        3T9K (3D)        3VI3 (3D)        3VI4 (3D)    
Secondary accessions: A8K6N2 D3DRX9 D3DRY3 D3DRY4 D3DRY5 P78466 P78467 Q13089 Q13090 Q13091
Q13212 Q14622 Q14647 Q29RW2 Q7Z3V1 Q8WUM6
Alternative splicing: 5 isoforms:  P05556-1   P05556-2   P05556-3   P05556-4   P05556-5   

Explore the universe of human proteins at neXtProt for ITGB1: NX_P05556

Explore proteomics data for ITGB1 at MOPED

Post-translational modifications: 

  • The cysteine residues are involved in intrachain disulfide bonds (By similarity)1
  • Ubiquitination2 at Lys774, Lys784, Lys794
  • Glycosylation2 at Asn50, Asn94, Asn97, Asn212, Asn269, Asn363, Thr394, Asn403, Asn406, Asn411,
                                 Asn417, Asn481, Asn520, Asn584, Asn669
  • Modification sites at PhosphoSitePlus

    • See ITGB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002202.2  NP_391988.1  NP_596867.1  

    ENSEMBL proteins: 
     ENSP00000303351   ENSP00000417508   ENSP00000417799   ENSP00000417537   ENSP00000420282  
     ENSP00000418725   ENSP00000431326   ENSP00000398029   ENSP00000417243   ENSP00000436214  
     ENSP00000404546   ENSP00000420792   ENSP00000420416   ENSP00000400544   ENSP00000379350  
     ENSP00000364094   ENSP00000388694  
    Reactome Protein details: P05556

    ITGB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ITGB1
    OriGene Protein Over-expression Lysate for ITGB1
    OriGene MassSpec for ITGB1
    OriGene Custom Protein Services for ITGB1
    GenScript Custom Purified and Recombinant Proteins Services for ITGB1
    Novus Biologicals ITGB1 Proteins
    Novus Biologicals ITGB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGB1
    R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
    Cell Signaling Technology (CST) Antibodies for ITGB1 
    OriGene Antibodies for ITGB1
    OriGene Custom Antibody Services for ITGB1
    Novus Biologicals ITGB1 Antibodies
    Abcam antibodies for ITGB1 (P26006, P05556)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGB1
    LSBio Antibodies in human, mouse, rat for ITGB1

    ITGB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGB1
    R&D Systems Proteome Profiler Antibody Arrays for ITGB1 (Integrin beta 1/CD29)
    GenScript Custom Assay Services for ITGB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for ITGB1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    Selected InterPro protein domains (see all 8):
     IPR027071 Integrin_beta-1
     IPR002369 Integrin_bsu_N
     IPR012896 Integrin_bsu_tail
     IPR015812 Integrin_bsu
     IPR014836 Integrin_bsu_cyt_dom

    Graphical View of Domain Structure for InterPro Entry P05556

    ProtoNet protein and cluster: P05556

    2 Blocks protein domains:
    IPB001169 Integrin beta
    IPB002369 Integrin beta subunit signature


    UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
    Similarity: Belongs to the integrin beta chain family
    Similarity: Contains 1 VWFA domain


    ITGB1 for domains           About GeneDecksing


    Function
    for ITGB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITB1_HUMAN, P05556
    Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for
    collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in
    collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1,
    alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one
    or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is
    a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are
    receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in
    VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
    A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.
    Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin
    alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of
    ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and
    migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to
    enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell
    adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis.
    Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process
    and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such
    as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or
    inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of
    cytokinesis
    Function: Isoform 5: Isoform 5 displaces isoform 1 in striated muscles (By similarity)

         Genatlas biochemistry entry for ITGB1:
    integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and
    fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies
    A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal
    cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal
    markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor
    p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0001948glycoprotein binding IEA--
    GO:0001968fibronectin binding IEA--
    GO:0002020protease binding IEA--
    GO:0003779actin binding IDA16803572
         
    ITGB1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ITGB1:
     Increased G2M DNA content, inc  Increased Salmonella enterica   Increased number of mitotic ce  Synthetic lethal with imatinib 
     Weaker migration 

         Selected MGI mutant phenotypes (inferred from 26 alleles) (MGI details for Itgb1) (see all 27):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    ITGB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGB1: Itgb1tm1Son Itgb1tm1Lscd Itgb1tm2Ref Itgb1tm1.1Efu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGB1

    miRNA
    Products:            		miRTarBase miRNAs that target ITGB1:
    hsa-mir-192-5p (MIRT026513), hsa-mir-124-3p (MIRT002731), hsa-mir-186-5p (MIRT044978), hsa-mir-183-5p (MIRT004015), hsa-mir-25-3p (MIRT050264), hsa-mir-9-3p (MIRT035520), hsa-mir-215-5p (MIRT024365), hsa-mir-769-5p (MIRT039178), hsa-mir-375 (MIRT019882)

    Block miRNA regulation of human, mouse, rat ITGB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGB1 (see all 13):
    hsa-miR-29c hsa-miR-29a hsa-miR-183 hsa-miR-513c hsa-miR-221* hsa-miR-548t hsa-miR-124 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ITGB1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ITGB1
    Predesigned siRNA for gene silencing in human, mouse, rat ITGB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ITGB1

    Clone
    Products:             		 OriGene clones in human, mouse for ITGB1 (see all 22)
    OriGene ORF clones in mouse, rat for ITGB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITGB1 (NM_033668)
    Sino Biological Human cDNA Clone for ITGB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ITGB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGB1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1


    Localization
    for ITGB1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    ITB1_HUMAN, P05556: Cell membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage
    furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 does not localize to focal
    adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a
    lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few
    intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By
    mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late
    telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells,
    in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1
    and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages
    of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar
    adhesions in a ITGB1BP1-dependent manner
    ITB1_HUMAN, P05556: Isoform 5: Cell membrane, sarcolemma (By similarity). Cell junction (By similarity). Note=In
    cardiac muscle, isoform 5 is found in costameres and intercalated disks (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum3
    extracellular3
    cytoskeleton2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0001726ruffle TAS11919189
    GO:0005604basement membrane IEA--
    GO:0005737cytoplasm IDA16803572
    GO:0005886plasma membrane TAS--

    ITGB1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ITGB1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for ITGB1 About   (see all 81)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    		Focal adhesion0.65
    		HGF Pathway0.34
    		Focal Adhesion0.65
    		ECM-receptor interaction0.31
    		Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    		Hypertrophic cardiomyopathy (HCM)0.75
    		Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    		Dilated cardiomyopathy0.75
    		Arrhythmogenic right ventricular cardiomyopathy0.54
    3Development Slit Robo signaling
    		Pathogenic Escherichia coli infection0.43
    		Pathogenic Escherichia coli infection0.41
    4VEGFR3 signaling in lymphatic endothelium
    		VEGFR3 signaling in lymphatic endothelium
    		Fibronectin matrix formation0.00
    5Integrin Pathway
    		FAK1 Signaling0.67
    		UPA-UPAR Pathway0.56
    		Integrin Pathway0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGB1
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGB1 (see all 38)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for ITGB1
        Angiogenesis
    Adhesion

    2 Tocris Bioscience Pathways for ITGB1
        NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for ITGB1 (see all 14)
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin inside-out signaling
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility

    Selected BioSystems Pathways for ITGB1 (see all 22)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Neural Crest Differentiation
    Arrhythmogenic right ventricular cardiomyopathy
    Pathogenic Escherichia coli infection


    Selected Reactome Pathways for ITGB1 (see all 15)
        Localization of the PINCH-ILK-PARVIN complex to focal adhesions
    Platelet Adhesion to exposed collagen
    Laminin interactions
    Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for ITGB1) (see all 21):
        Rap1 signaling pathway
    Phagosome
    PI3K-Akt signaling pathway
    Axon guidance
    Focal adhesion


    ITGB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB1 (see all 15): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGB1 (P055561, 2, 3 ENSP000003640944) via UniProtKB, MINT, STRING, and/or I2D (see all 327)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD63P089622, 3, ENSP000002578574MINT-2981958 MINT-2981939 MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    FHL2Q141922, 3, ENSP000003229094MINT-16547 MINT-16546 I2D: score=4 STRING: ENSP00000322909
    ENGP178131, 2EBI-703066,EBI-2834630 MINT-8410725 MINT-8415241 MINT-8410698
    ITGA2P173011, 3, ENSP000002965854EBI-703066,EBI-702960 I2D: score=3 STRING: ENSP00000296585
    CSF2RBP329271, 3, ENSP000003840534EBI-703066,EBI-1809771 I2D: score=2 STRING: ENSP00000384053
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 57):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001708cell fate specification IEA--
    GO:0001894tissue homeostasis IEA--
    GO:0002042cell migration involved in sprouting angiogenesis IEA--

    ITGB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITGB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ITGB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    1 DrugBank Compound for ITGB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600

    Selected Novoseek inferred chemical compound relationships for ITGB1 gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grgdsp 65.5 1 7648723 (1)
    kalinin 63.9 1 8876604 (1)
    herbimycin a 57.6 4 15546505 (1), 8089188 (1), 9230816 (1), 12209735 (1)
    tyrosine 48.7 52 11250890 (3), 7520449 (3), 7592610 (2), 10395641 (2) (see all 37)
    matrigel 48.7 2 8740459 (2)
    cytochalasin b 39.3 2 14706635 (1), 8989906 (1)
    adapalene 38.9 1 19657615 (1), 19903100 (1)
    phosphotyrosine 35.3 5 7577832 (1), 7527397 (1), 8546227 (1), 8748369 (1) (see all 5)
    slex 35.1 2 9733622 (1), 18334960 (1)
    genistein 30.5 2 11315093 (1), 8089188 (1)



    ITGB1 for compounds           About GeneDecksing



    Transcripts
    for ITGB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ITGB1 gene (6 alternative transcripts): 
    NM_002211.3  NM_033668.2  NM_133376.2  NM_033666.2  NM_033667.2  NM_033669.2  

    Unigene Cluster for ITGB1:

    Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    Hs.643813  [show with all ESTs]
    Unigene Representative Sequence: NM_002211
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000302278 ENST00000488427 ENST00000494395 ENST00000484088 ENST00000480226
    ENST00000474568 ENST00000488494 ENST00000534049 ENST00000437302 ENST00000475184
    ENST00000528877 ENST00000417122 ENST00000464001 ENST00000493758 ENST00000472147
    ENST00000414670 ENST00000439974 ENST00000396033(uc001iws.4)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ITGB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGB1 (see all 13):
    hsa-miR-29c hsa-miR-29a hsa-miR-183 hsa-miR-513c hsa-miR-221* hsa-miR-548t hsa-miR-124 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ITGB1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ITGB1
    Predesigned siRNA for gene silencing in human, mouse, rat ITGB1
    Clone
    Products:             		 OriGene clones in human, mouse for ITGB1 (see all 22)
    OriGene ORF clones in mouse, rat for ITGB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITGB1 (NM_033668)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGB1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for ITGB1
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGB1
      QuantiTect SYBR Green Assays in human, mouse, rat ITGB1
      QuantiFast Probe-based Assays in human, mouse, rat ITGB1

    Additional mRNA sequence: 

    AK291697.1 BC020057.1 BC113901.1 BX537407.1 M34189.1 U28252.1 

    Selected DOTS entries (see all 46):

    DT.95250205  DT.95144425  DT.92411211  DT.100889329  DT.92468841  DT.65286518  DT.102839004  DT.100659208 
    DT.100889330  DT.92468837  DT.100889334  DT.100889338  DT.100889349  DT.100889328  DT.121292288  DT.100045345 
    DT.100889343  DT.121292182  DT.95172289  DT.95129453  DT.121292178  DT.97820426  DT.100889347  DT.121292202 

    Selected AceView cDNA sequences (see all 1076):

    AV660413 BM975072 AA344631 AU280595 W39486 CN482345 AW471282 AW073508 
    AA625397 AI249245 CR618169 CN484393 AA393858 AI637935 BM788072 CB143602 
    BE076329 BM541713 AV645488 BQ946348 AA029726 BX505769 NM_033668 AI755271 

    GeneLoc Exon Structure


    Expression
    for ITGB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ITGB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGTTATA
    ITGB1 Expression
    About this image


    ITGB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 44) fully expand
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Decidua-derived mesenchymal stem cells
     
     Tooth (Integumentary System)    fully expand to see all 14 entries
             Dental Pulp Stem Cells Dental Pulp
             Dental pulp stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 12 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (HYNR-CS inj)
     
     Adipose (Muscoskeletal System)    fully expand to see all 11 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 9 entries
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Decidua-derived mesenchymal stem cells
             placenta ; decidual cells   
    ITGB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ITGB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643813

    UniProtKB/Swiss-Prot: ITB1_HUMAN, P05556
    Tissue specificity: Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted
    distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein
    endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and
    isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial
    cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than
    isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and
    differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in
    various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac
    muscle)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGB1 (see all 15): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for ITGB1
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGB1
    QuantiTect SYBR Green Assays in human, mouse, rat ITGB1
    QuantiFast Probe-based Assays in human, mouse, rat ITGB1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGB1

    Orthologs
    for ITGB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ITGB1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Itgb11 , 5 integrin beta 1 (fibronectin receptor beta)1, 5 87.72(n)1
    92.48(a)1    		   8 (76.09 cM)5
    164121  NM_010578.21  NP_034708.11 
     1286856545 
    chicken
    (Gallus gallus)    		 Aves ITGB11 integrin, beta 1 (fibronectin receptor, beta polypeptide, more 78.8(n)
    85.14(a)    		   374058  NM_001039254.2  NP_001034343.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ITGB16
    		 integrin, beta 1 (fibronectin receptor, beta polyp...
    		 79(a)
    		 1 ↔ 1
    		 6(12274686-12325701)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.76232 X.laevis integrin beta-1* subunit mRNA, complete cds 78.8(n)    M20180.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii itgb1a1 integrin, beta 1a 68.93(n)
    78.17(a)    		   556734  NM_001034971.1  NP_001030143.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mys1 , 3 central nervous system development
    calcium-dependent more3
    myospheroid1    		 42(a)
    (best of 2)3
    51.11(n)1
    47.58(a)1    		   448851  NM_080054.21  NP_524793.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea pat-31 , 3 beta integrin3
    pat-31    		 41(a)3
    51.86(n)1
    43.35(a)1    		   III(3981133-3985933)3
    1755041  NM_065386.51  NP_497787.11 


    ENSEMBL Gene Tree for ITGB1 (if available)
    TreeFam Gene Tree for ITGB1 (if available)

    Paralogs
    for ITGB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ITGB1 gene
    ITGB42  ENSG000002597532  ITGB72  ITGB22  ITGBL12  ITGB32  ITGB82  ITGB62  
    ITGB52  
    6 SIMAP similar genes for ITGB1 using alignment to 14 protein entries:     ITB1_HUMAN (see all proteins):
    ITGB5    ITGB8    ITGB3    ITGB7    ITGB2    ITGB6

    ITGB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGB1
    PGOHUM00000234172


    Genomic Variants
    for ITGB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ITGB1 (see all 1359)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs777445831,2
    		C--32916639(+) GGATG-/CTTT  
                CTGTT     		3 -- int10--------
    rs30351751,2
    		C--32916641(+) ATGCTTTCT/-  
                GTTTT     		3 -- int15Minor allele frequency- -:0.21EU NA MN 382
    rs1471600131,2
    		C--32926365(+) GCAAA-/GACTTG 3 -- int10--------
    rs348875341,2
    		C--32939397(+) AATGTG/-GGGGA 3 -- int11Minor allele frequency- -:0.50NA 2
    rs562805521,2
    		C--32946020(+) AAAAA-/AAAAAAA
    /AAAAAAAA    GAGTT     		2 -- int11NA 2
    rs357573671,2
    		C--32955194(+) GGGGG-/GATTAT 2 -- int10--------
    rs1834209901,2
    		--32955205(+) GGGGGG/TGGGAT 2 -- int10--------
    rs1486944781,2
    		C--32955878(+) TAGCC-/GTGTGT
    /GTGTGTGT    GTGTG     		4 -- int1 cds10--------
    rs1414346471,2
    		--32955923(+) TGTACA/GTACAT 2 -- int10--------
    rs11870761,2
    		C,F,A--32966421(+) ACTTCT/CTCCTG 2 -- us2k1 int16Minor allele frequency- C:0.22MN NA 312

    HapMap Linkage Disequilibrium report for ITGB1 (33189246 - 33294720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITGB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999118CNV Loss20482838
    esv23179CNV Loss19812545
    nsv831827CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGB1

    Disorders / Diseases
    for ITGB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 135630    OMIM disorders: --

    Selected diseases for ITGB1 (see all 147):    
    About MalaCards
    sipple syndrome    cerebral hypoxia    frozen shoulder    pustulosis palmaris et plantaris
    plasma cell leukemia    bullous keratopathy    actinic cheilitis    nephrotic syndrome
    hemorrhagic fever with renal syndrome    cheilitis    keratopathy    glanders
    oral leukoplakia    fraser syndrome    dermatitis herpetiformis    von willebrand's disease
    leukoplakia    synovitis    focal segmental glomerulosclerosis    teratocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ITGB1:
    Cancer

    ITGB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ITGB1 gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 38.7 30 8630057 (3), 8006453 (3), 8694563 (3), 1293173 (2) (see all 16)
    tumors 38.3 71 7508107 (5), 11319874 (4), 7529636 (4), 7526040 (3) (see all 47)
    metastasis 34 15 14666731 (2), 1282908 (1), 9337541 (1), 1293172 (1) (see all 12)
    myeloma 27.1 11 7861616 (1), 18850009 (1), 9513075 (1), 7686332 (1) (see all 6)
    fibrosarcoma 25.6 1 11921440 (1)
    colon carcinoma 23.7 1 7509799 (1)
    necrosis 23.2 7 1723314 (1), 9348298 (1), 10417618 (1), 10235499 (1) (see all 6)
    osteosarcoma 22.5 4 8326445 (2), 8010959 (1), 7541624 (1)
    nephrotic syndrome minimal change 21.9 2 9355070 (1)
    plasma cell leukemia 20.6 1 7686332 (1)

    Genetic Association Database (GAD): ITGB1
    Human Genome Epidemiology (HuGE) Navigator: ITGB1 (18 documents)

    Export disorders for ITGB1 gene to outside databases

    Publications
    for ITGB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ITGB1 gene, integrated from 10 sources (see all 1512):
    (articles sorted by number of sources associating them with ITGB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. (PubMed id 22451694)1, 2 Nagae M.... Takagi J. (J. Cell Biol. 2012)
    2. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. (PubMed id 21325030)1, 2 Qu H.... Wu C. (J. Cell Sci. 2011)
    3. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin I^1 recycling in cell migration. (PubMed id 22027826)1, 2 Yu X....Yao X. (J. Biol. Chem. 2011)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    5. The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. (PubMed id 20660204)1, 2 Feire A.L.... Compton T. (J. Virol. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    8. Genome-wide association scan of trait depression. (PubMed id 20800221)1, 4 Terracciano A....Costa P.T. (Biol. Psychiatry 2010)
    9. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)
    10. Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. (PubMed id 18057877)1, 4 Saidi S....Almawi W.Y. (Cerebrovasc. Dis. 2008)

    External Searches for ITGB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITGB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3688 HGNC: 6153 AceView: ITGB1 Ensembl:ENSG00000150093 euGenes: HUgn3688
    ECgene: ITGB1 Kegg: 3688 H-InvDB: ITGB1

    Other Databases showing ITGB1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing ITGB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGB1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD29

    Intellectual Property
    for ITGB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for ITGB1 gene:
    Search GeneIP for patents involving ITGB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ITGB1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Block miRNA regulation of human, mouse, rat ITGB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ITGB1
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for ITGB1
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGB1
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