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Aliases for ITGAX Gene

Aliases for ITGAX Gene

  • Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit) 2 3
  • Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide) 2 3
  • Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain 3 4
  • Leukocyte Adhesion Receptor P150,95 3 4
  • CD11 Antigen-Like Family Member C 3 4
  • CD11C 3 4
  • Leukocyte Surface Antigen P150,95, Alpha Subunit 3
  • Myeloid Membrane Antigen, Alpha Subunit 3
  • P150 95 Integrin Alpha Chain 3
  • Leu M5, Alpha Subunit 3
  • CD11c Antigen 4
  • Leu M5 4
  • SLEB6 3

External Ids for ITGAX Gene

Previous HGNC Symbols for ITGAX Gene

  • CD11C

Previous GeneCards Identifiers for ITGAX Gene

  • GC16P030448
  • GC16P031863
  • GC16P031363
  • GC16P031402
  • GC16P031274
  • GC16P028926

Summaries for ITGAX Gene

Entrez Gene Summary for ITGAX Gene

  • This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ITGAX Gene

ITGAX (Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit)) is a Protein Coding gene. Diseases associated with ITGAX include systemic lupus erythematous, association with 6 and benign cephalic histiocytosis. Among its related pathways are Regulation of actin cytoskeleton and TGF-Beta Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAX Gene

  • Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis

Gene Wiki entry for ITGAX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAX Gene

Genomics for ITGAX Gene

Regulatory Elements for ITGAX Gene

Genomic Location for ITGAX Gene

Chromosome:
16
Start:
31,355,134 bp from pter
End:
31,382,997 bp from pter
Size:
27,864 bases
Orientation:
Plus strand

Genomic View for ITGAX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAX Gene

Proteins for ITGAX Gene

  • Protein details for ITGAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20702-ITAX_HUMAN
    Recommended name:
    Integrin alpha-X
    Protein Accession:
    P20702
    Secondary Accessions:
    • Q8IVA6

    Protein attributes for ITGAX Gene

    Size:
    1163 amino acids
    Molecular mass:
    127829 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

    Three dimensional structures from OCA and Proteopedia for ITGAX Gene

neXtProt entry for ITGAX Gene

Proteomics data for ITGAX Gene at MOPED

Post-translational modifications for ITGAX Gene

  • Glycosylation at Asn 61, Asn 89, Asn 392, Asn 697, Asn 735, Asn 899, Asn 904, Asn 939, and Asn 1050
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGAX Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for ITGAX

No data available for DME Specific Peptides for ITGAX Gene

Domains & Families for ITGAX Gene

Suggested Antigen Peptide Sequences for ITGAX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20702

UniProtKB/Swiss-Prot:

ITAX_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAX: view

Function for ITGAX Gene

Molecular function for ITGAX Gene

GENATLAS Biochemistry:
integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in fibrinogen,C3b receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis

Gene Ontology (GO) - Molecular Function for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2303426
GO:0005515 protein binding IPI 17726152
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGAX: view
genes like me logo Genes that share phenotypes with ITGAX: view

Animal Models for ITGAX Gene

MGI Knock Outs for ITGAX:

Animal Model Products

miRNA for ITGAX Gene

miRTarBase miRNAs that target ITGAX

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGAX

Clone Products

  • Addgene plasmids for ITGAX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGAX Gene

Localization for ITGAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAX Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAX Gene COMPARTMENTS Subcellular localization image for ITGAX gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
cytosol 2
extracellular 2
lysosome 2
nucleus 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009897 external side of plasma membrane --
GO:0009986 cell surface IDA 19234460
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ITGAX: view

Pathways & Interactions for ITGAX Gene

genes like me logo Genes that share pathways with ITGAX: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ITGAX Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 2303426
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0009887 organ morphogenesis TAS 3327687
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ITGAX: view

Drugs & Compounds for ITGAX Gene

(5) Drugs for ITGAX Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Nitric Oxide Approved Pharma 540
Ornithine Approved Nutra Full agonist, Agonist 31
arachidonic acid Experimental Nutra Potentiation, Activator 27

(14) Additional Compounds for ITGAX Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
butyrate
Cycloheximide
Cytochalasin D
FIBRINOGEN
FMLP
genes like me logo Genes that share compounds with ITGAX: view

Transcripts for ITGAX Gene

Unigene Clusters for ITGAX Gene

Integrin, alpha X (complement component 3 receptor 4 subunit):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGAX

Clone Products

  • Addgene plasmids for ITGAX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ITGAX Gene

GeneLoc Exon Structure for
ITGAX
ECgene alternative splicing isoforms for
ITGAX

Expression for ITGAX Gene

mRNA expression in normal human tissues for ITGAX Gene

mRNA differential expression in normal tissues according to GTEx for ITGAX Gene

This gene is overexpressed in Whole Blood (x33.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for ITGAX Gene

This gene is overexpressed in Lymph node (18.9), Monocytes (15.7), and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAX Gene



SOURCE GeneReport for Unigene cluster for ITGAX Gene Hs.248472

mRNA Expression by UniProt/SwissProt for ITGAX Gene

P20702-ITAX_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes
genes like me logo Genes that share expression patterns with ITGAX: view

Protein tissue co-expression partners for ITGAX Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ITGAX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAX Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ITGAX 35
  • 81.47 (n)
  • 76.54 (a)
ITGAX 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgax 35
  • 76.94 (n)
  • 71.92 (a)
Itgax 16
Itgax 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGAX 35
  • 98.56 (n)
  • 98.59 (a)
ITGAX 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgax 35
  • 76.59 (n)
  • 72.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32n7.4 36
  • 36 (a)
ManyToMany
Species with no ortholog for ITGAX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAX Gene

ENSEMBL:
Gene Tree for ITGAX (if available)
TreeFam:
Gene Tree for ITGAX (if available)

Paralogs for ITGAX Gene

(5) SIMAP similar genes for ITGAX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ITGAX Gene

genes like me logo Genes that share paralogs with ITGAX: view

Variants for ITGAX Gene

Sequence variations from dbSNP and Humsavar for ITGAX Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2929 -- 31,381,987(+) GGGGA(A/G)GAACC utr-variant-3-prime, intron-variant, downstream-variant-500B
rs1106398 -- 31,359,131(+) TCACT(C/T)TTTTG intron-variant
rs1140191 -- 31,382,372(+) tcctg(A/C)gtagc utr-variant-3-prime, intron-variant
rs1140193 -- 31,382,567(+) GAGAG(C/G)CTCTG utr-variant-3-prime
rs1140194 -- 31,382,657(+) CGATT(C/T)CCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ITGAX Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
esv2714194 CNV Deletion 23290073
nsv905747 CNV Gain 21882294

Variation tolerance for ITGAX Gene

Residual Variation Intolerance Score: 15.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAX Gene

HapMap Linkage Disequilibrium report
ITGAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAX Gene

Disorders for ITGAX Gene

MalaCards: The human disease database

(13) MalaCards diseases for ITGAX Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematous, association with 6
  • systemic lupus erythematous, association with susceptibility to, 6
benign cephalic histiocytosis
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
bladder lymphoma
  • lymphoma of the urinary bladder
non-secretory myeloma
- elite association
Search ITGAX in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAX

Genetic Association Database (GAD)
ITGAX
Human Genome Epidemiology (HuGE) Navigator
ITGAX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAX
genes like me logo Genes that share disorders with ITGAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAX Gene

Publications for ITGAX Gene

  1. Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. (PMID: 19800635) Brummett B.H. … Williams R.B. (J Psychiatr Res 2010) 23 67
  2. Impaired terminal differentiation of pulmonary macrophages in a Guinea pig model of chronic ethanol ingestion. (PMID: 19645732) Brown S.D. … Brown L.A. (Alcohol. Clin. Exp. Res. 2009) 23 67
  3. Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation. (PMID: 19199469) Parney I.F. … Parsa A.T. (J. Neurosurg. 2009) 23 67
  4. Mesenchymal cells from limbal stroma of human eye. (PMID: 18334960) Polisetty N. … Vemuganti G.K. (Mol. Vis. 2008) 23 67
  5. All-trans retinoic acid induces different immunophenotypic changes on human HL60 and NB4 myeloid leukaemias. (PMID: 17561254) Barber N. … Christopherson R.I. (Leuk. Res. 2008) 23 67

Products for ITGAX Gene

Sources for ITGAX Gene

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