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ITGAX Gene

protein-coding   GIFtS: 65
GCID: GC16P031366

Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit)

(Previous names: integrin, alpha X (antigen CD11C (p150), alpha polypeptide))
(Previous symbol: CD11C)
  See ITGAX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit)1 2     Integrin Alpha-X2
CD11C1 2 3 5     Leu M5, Alpha Subunit2
Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide)1 2     Leukocyte Surface Antigen P150,95, Alpha Subunit2
Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain2 3     Myeloid Membrane Antigen, Alpha Subunit2
Leukocyte Adhesion Receptor P150,952 3     P150 95 Integrin Alpha Chain2
CD11 Antigen-Like Family Member C2 3     CD11c Antigen3
SLEB62     Leu M53

External Ids:    HGNC: 61521   Entrez Gene: 36872   Ensembl: ENSG000001406787   OMIM: 1515105   UniProtKB: P207023   

Export aliases for ITGAX gene to outside databases

Previous GC identifers: GC16P030448 GC16P031863 GC16P031363 GC16P031402 GC16P031274 GC16P028926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGAX Gene:
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins
composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a
leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex
seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to
stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2013)

GeneCards Summary for ITGAX Gene:
ITGAX (integrin, alpha X (complement component 3 receptor 4 subunit)) is a protein-coding gene. Diseases associated with ITGAX include benign cephalic histiocytosis, and sporotrichosis. GO annotations related to this gene include receptor activity. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702
Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It
mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and
chemotaxis

Gene Wiki entry for ITGAX (CD11c) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGAX gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   Sp1   NRSF form 1   c-Myb   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGAX promoter sequence
   Search Chromatin IP Primers for ITGAX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ITGAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAX gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031366:  view genomic region     (about GC identifiers)

Start:
31,366,455 bp from pter      End:
31,394,318 bp from pter
Size:
27,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702 (See protein sequence)
Recommended Name: Integrin alpha-X precursor  
Size: 1163 amino acids; 127829 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2
Selected PDB 3D structures from and Proteopedia for ITGAX (see all 7):
1N3Y (3D)        2LUV (3D)        3K6S (3D)        3K71 (3D)        3K72 (3D)        4NEH (3D)    
Secondary accessions: Q8IVA6

Explore the universe of human proteins at neXtProt for ITGAX: NX_P20702

Explore proteomics data for ITGAX at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61, Asn89, Asn392, Asn697, Asn735, Asn899, Asn939, Asn1050
  • Modification sites at PhosphoSitePlus

  • See ITGAX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000878.2  NP_001273304.1  

    ENSEMBL proteins: 
     ENSP00000268296   ENSP00000454623  
    Reactome Protein details: P20702

    ITGAX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGAX (CD11c, Integrin alpha X beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITGAX
    GenScript Custom Purified and Recombinant Proteins Services for ITGAX
    Novus Biologicals ITGAX Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGAX 

    ITGAX Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAX
    R&D Systems Antibodies for ITGAX (CD11c)
    OriGene Antibodies for ITGAX
    OriGene Custom Antibody Services for ITGAX
    Novus Biologicals ITGAX Antibodies
    Abcam antibodies for ITGAX (P11215, P20702)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGAX
    LSBio Antibodies in human, mouse, rat for ITGAX

    ITGAX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAX
    R&D Systems Proteome Profiler Antibody Arrays for ITGAX (CD11c)
    GenScript Custom Assay Services for ITGAX
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGAX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins
    complement: Complement system

    Selected InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P20702

    ProtoNet protein and cluster: P20702

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGAX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAX_HUMAN, P20702
    Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It
    mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and
    chemotaxis

         Genatlas biochemistry entry for ITGAX:
    integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB2 in fibrinogen,C3b receptor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS2303426
    GO:0005515protein binding IPI17726152
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGAX           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itgax):
     hematopoietic system  immune system  no phenotypic analysis  normal 

    Find genes that share phenotypes with ITGAX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itgaxtm1Bll for ITGAX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGAX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGAX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAX

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGAX:
    hsa-mir-26b-5p (MIRT030204)

    Block miRNA regulation of human, mouse, rat ITGAX using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ITGAX:
    hsa-miR-3613-3p hsa-miR-3908 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidITGAX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGAX
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAX

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAX (see all 6)
    OriGene ORF clones in mouse, rat for ITGAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAX (NM_000887)
    Sino Biological Human cDNA Clone for ITGAX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAX
    Addgene plasmids for ITGAX 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAX

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12824) for ITGAX 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITAX_HUMAN, P20702: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    extracellular2
    cytoskeleton1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ITGAX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGAX About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with ITGAX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGAX (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 GeneGo (Thomson Reuters) Pathways for ITGAX
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    2 BioSystems Pathways for ITGAX
        Focal Adhesion
    Integrin-mediated cell adhesion


    3 Reactome Pathways for ITGAX
        ECM proteoglycans
    Integrin cell surface interactions
    Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for ITGAX):
        Regulation of actin cytoskeleton
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAX (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGAX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGAX (P207023 ENSP000002682964) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051073, ENSP000003032424I2D: score=4 STRING: ENSP00000303242
    C3P010243, ENSP000002459074I2D: score=3 STRING: ENSP00000245907
    JAM3Q9BX673, ENSP000002991064I2D: score=1 STRING: ENSP00000299106
    FCER2P067343, ENSP000002640724I2D: score=2 STRING: ENSP00000264072
    CEBPAP497153I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0009887organ morphogenesis TAS3327687
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with ITGAX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGAX (ITAX)

    Selected Novoseek inferred chemical compound relationships for ITGAX gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 53.7 3 1680065 (1), 7669656 (1), 12610322 (1)
    phorbol-12-myristate 53 3 8649405 (1), 9360988 (1)
    n-formylmethionyl-leucylphenylalanine 44.7 1 1680065 (1)
    phorbol 39.5 3 8649434 (1), 8649405 (1)
    pdtc 30.4 3 8631910 (2)
    retinoic acid 28.3 10 17561254 (3), 10641747 (1), 9067636 (1), 16764927 (1) (see all 5)
    fibrinogen 22.5 2 7669656 (1), 12393714 (1)
    cytochalasin d 16.2 2 7669656 (2)
    cycloheximide 15.2 2 9160089 (1), 7739574 (1)
    ornithine 14.1 1 1673351 (1)



    Find genes that share compounds with ITGAX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGAX gene (2 alternative transcripts): 
    NM_000887.4  NM_001286375.1  

    Unigene Cluster for ITGAX:

    Integrin, alpha X (complement component 3 receptor 4 subunit)
    Hs.248472  [show with all ESTs]
    Unigene Representative Sequence: NM_000887
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564308 ENST00000268296(uc002ebt.3 uc002ebu.1) ENST00000562918
    ENST00000567409(uc010cao.1) ENST00000562522(uc010vfk.1) ENST00000571644
    ENST00000562138
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGAX using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ITGAX:
    hsa-miR-3613-3p hsa-miR-3908 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidITGAX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGAX
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAX
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAX (NM_000887)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAX
    Addgene plasmids for ITGAX 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAX
      QuantiTect SYBR Green Assays in human, mouse, rat ITGAX
      QuantiFast Probe-based Assays in human, mouse, rat ITGAX
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12824) for ITGAX 

    Additional mRNA sequence: 

    AK293367.1 AK296666.1 AK309642.1 BC038237.1 M81695.1 

    13 DOTS entries:

    DT.95262776  DT.411782  DT.95262956  DT.120664138  DT.101972447  DT.102822469  DT.120664143  DT.120664150 
    DT.95177642  DT.97821814  DT.99964818  DT.100672898  DT.97785802 

    Selected AceView cDNA sequences (see all 45):

    AW014280 BC037577 NM_000887 AA258227 BC038237 CD369592 AW206231 AA251501 
    N28267 AI950296 BG427526 AI963970 M81695 AA251543 AA259072 CA308944 
    AW968280 AI144342 AW196330 BP361262 BM923194 AW003517 BX644051 BQ312815 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                          -                                                                                   -                                             
    SP2:                          -                                                                                   -                                             
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:  -                                                                           
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ITGAX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGAX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTTTTT
    ITGAX Expression
    About this image


    ITGAX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 8 entries
             pre Conventional Dendritic Cells Peripheral Blood
             Mouse immunosuppressive dendritic cells
             Monocyte-like cells
     
     Spleen (Hematopoietic System)    fully expand to see all 4 entries
             Conventional Dendritic Cells I Spleen
             spleen ; cells in red pulp   
     
     Adipose (Muscoskeletal System)
             Stromal Cells Subcutaneous White Adipose
    ITGAX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGAX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248472

    UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702
    Tissue specificity: Predominantly expressed in monocytes and granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAX (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGAX gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgax1 , 5 integrin alpha X1, 5 76.94(n)1
    71.92(a)1
      7 (69.98 cM)5
    164111  NM_021334.21  NP_067309.11 
     1281295685 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    47(a)
    46(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343220.1(2388207-2422669)
    GL343220.1(2431120-2468441)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-32n7.46
    si:dkey-32n7.4
    36(a)
    many ↔ many
    12(4794914-4825546) ENSDARG00000002956


    ENSEMBL Gene Tree for ITGAX (if available)
    TreeFam Gene Tree for ITGAX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGAX gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    5 SIMAP similar genes for ITGAX using alignment to 2 protein entries:     ITAX_HUMAN (see all proteins):
    FLJ00114    ITGAD    ITGAM    ITGA2    ITGAL

    Find genes that share paralogs with ITGAX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ITGAX
    PGOHUM00000248808


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGAX (see all 871)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429795651,2
    C--28930391(+) CCTGG-/TTTTTT 1 -- int10--------
    rs1511839971,2
    C--28936597(+) TCTCG-/AACA  
            
    AACAA
    1 -- int10--------
    rs1450683571,2
    C--28937500(+) TCTCT-/AAAC  
            
    AAACA
    1 -- int10--------
    rs721131821,2
    C--28937501(+) CTCTA-/AAAC  
            
    AACAA
    1 -- int10--------
    rs1390451781,2
    C--28944492(+) AACAA-/AAC/AA
    CAACAAC
    /C
    AACAA
    3 -- int1 cds10--------
    rs586597241,2
    C--28944520(+) CAACA-/ACA/
    CAACAACA
    TCACT
    2 -- cds10--------
    rs1113074761,2
    C--28945864(+) AAAAAA/-GTTAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs113242301,2
    C--28950396(+) CTCTC-/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.00CSA 2
    rs2011472231,2
    --28950410(+) TTTTT-/TGAGACC 1 -- int10--------
    rs615758061,2
    C--28953806(+) CTTTCT/-TTTTT 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for ITGAX (31366455 - 31394318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITGAX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714194CNV Deletion23290073
    nsv833194CNV Loss17160897
    nsv905747CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAX
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151510    OMIM disorders: --

    6 diseases for ITGAX:    
    About MalaCards
    benign cephalic histiocytosis    sporotrichosis    lymphocytic vasculitis    vasculitis
    leukocyte adhesion deficiency    acute promyelocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for ITGAX:
    Hairy cell leukemia

    Find genes that share disorders with ITGAX           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGAX gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia hairy cell 60.9 1 12576324 (1)
    lymphoproliferative disorders 21.8 1 10721778 (1)
    splenomegaly 15.8 1 2234204 (1)
    inflammation 12 3 14688376 (1), 19702851 (1), 11151969 (1)
    leukemia 10.8 4 1689668 (2), 17561254 (1), 2328771 (1)
    colitis ulcerative 0.886 1 9473377 (1)
    acute leukemia 0 1 9658721 (1)
    lymphoma non-hodgkins 0 1 10979212 (1)
    lymphoma 0 1 11937543 (1)
    preeclampsia 0 2 11799095 (2)

    Genetic Association Database (GAD): ITGAX
    Human Genome Epidemiology (HuGE) Navigator: ITGAX (5 documents)

    Export disorders for ITGAX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGAX gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with ITGAX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PubMed id 2303426)1, 2, 3 Corbi A.L.... Springer T.A. (J. Biol. Chem. 1990)
    2. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)1, 4, 9 Hellmig S....Schreiber S. (Tissue Antigens 2005)
    3. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)1, 4, 9 Hom G....Behrens T.W. (N. Engl. J. Med. 2008)
    4. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    5. Structure of an integrin with an alphaI domain, complement receptor type 4. (PubMed id 20033057)1, 2 Xie C.... Springer T.A. (EMBO J. 2010)
    6. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). (PubMed id 19129174)1, 4 Han S....Nath S.K. (Hum. Mol. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. (PubMed id 3284962)1, 3 Corbi A.L....Morton C.C. (J. Exp. Med. 1988)
    9. Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins. (PubMed id 3549901)1, 2 Miller L.J.... Springer T.A. (J. Immunol. 1987)
    10. cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. (PubMed id 3327687)1, 2 Corbi A.L.... Springer T.A. (EMBO J. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3687 HGNC: 6152 AceView: ITGAX Ensembl:ENSG00000140678 euGenes: HUgn3687
    ECgene: ITGAX Kegg: 3687 H-InvDB: ITGAX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGAX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGAX gene:
    Search GeneIP for patents involving ITGAX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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