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Aliases for ITGAX Gene

Aliases for ITGAX Gene

  • Integrin Subunit Alpha X 2 3 5
  • Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit) 2 3
  • Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide) 2 3
  • Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain 3 4
  • Complement Component 3 Receptor 4 Subunit 2 3
  • Leukocyte Adhesion Receptor P150,95 3 4
  • CD11 Antigen-Like Family Member C 3 4
  • CD11C 3 4
  • Leukocyte Surface Antigen P150,95, Alpha Subunit 3
  • Myeloid Membrane Antigen, Alpha Subunit 3
  • P150 95 Integrin Alpha Chain 3
  • Leu M5, Alpha Subunit 3
  • Integrin Alpha X 3
  • Integrin Alpha-X 3
  • CD11c Antigen 4
  • Leu M5 4
  • SLEB6 3

External Ids for ITGAX Gene

Previous HGNC Symbols for ITGAX Gene

  • CD11C

Previous GeneCards Identifiers for ITGAX Gene

  • GC16P030448
  • GC16P031863
  • GC16P031363
  • GC16P031402
  • GC16P031274
  • GC16P028926

Summaries for ITGAX Gene

Entrez Gene Summary for ITGAX Gene

  • This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ITGAX Gene

ITGAX (Integrin Subunit Alpha X) is a Protein Coding gene. Diseases associated with ITGAX include Hairy Cell Leukemia and Benign Cephalic Histiocytosis. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and ECM proteoglycans. GO annotations related to this gene include receptor activity. An important paralog of this gene is ITGAD.

UniProtKB/Swiss-Prot for ITGAX Gene

  • Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Gene Wiki entry for ITGAX Gene

Additional gene information for ITGAX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAX Gene

Genomics for ITGAX Gene

Regulatory Elements for ITGAX Gene

Enhancers for ITGAX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H031351 1.9 FANTOM5 Ensembl ENCODE dbSUPER 35.6 -0.3 -327 7 HDGF PKNOX1 ATF1 TBL1XR1 KLF17 BATF RAD21 RFX5 EGR1 FOS ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 ZNF764 HSD3B7 LOC647086
GH16H031349 1.5 FANTOM5 Ensembl ENCODE dbSUPER 30.7 -4.7 -4719 1 BCOR SMARCA5 ZNF146 ZMYM3 MAX EGR2 ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 HSD3B7 ZNF668 FUS
GH16H031116 1.7 FANTOM5 ENCODE dbSUPER 26 -236.7 -236722 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 SETD1A SRCAP KAT8 STX4 ENSG00000261614 ITGAX NPIPB13 ZNF720 ZNF747 SMG1P5
GH16H031125 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.8 -224.0 -223996 10 HDGF ARNT SIN3A ZNF766 ZNF207 ZNF548 SP3 MCM3 ZNF592 SREBF1 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C TGFB1I1 ITGAX
GH16H031111 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.3 -241.8 -241809 3 DRAP1 SAP130 ARID4B MAX RAD21 ZNF121 POLR2A PRDM10 NFE2 NR2F6 KAT8 ITGAX STX4 ZNF785 ZNF720 FUS MIR762HG ENSG00000260625 ZNF747 ZNF646
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGAX on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGAX Gene

Chromosome:
16
Start:
31,355,134 bp from pter
End:
31,382,997 bp from pter
Size:
27,864 bases
Orientation:
Plus strand

Genomic View for ITGAX Gene

Genes around ITGAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAX Gene

Proteins for ITGAX Gene

  • Protein details for ITGAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20702-ITAX_HUMAN
    Recommended name:
    Integrin alpha-X
    Protein Accession:
    P20702
    Secondary Accessions:
    • Q8IVA6

    Protein attributes for ITGAX Gene

    Size:
    1163 amino acids
    Molecular mass:
    127829 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

    Three dimensional structures from OCA and Proteopedia for ITGAX Gene

neXtProt entry for ITGAX Gene

Post-translational modifications for ITGAX Gene

  • Glycosylation at posLast=6161, posLast=8989, isoforms=392, posLast=697697, posLast=735735, posLast=899899, posLast=904904, isoforms=939, and isoforms=1050
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGAX Gene

No data available for DME Specific Peptides for ITGAX Gene

Domains & Families for ITGAX Gene

Gene Families for ITGAX Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ITGAX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20702

UniProtKB/Swiss-Prot:

ITAX_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGAX: view

Function for ITGAX Gene

Molecular function for ITGAX Gene

GENATLAS Biochemistry:
integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in fibrinogen,C3b receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Phenotypes From GWAS Catalog for ITGAX Gene

Gene Ontology (GO) - Molecular Function for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2303426
GO:0005515 protein binding IPI 17726152
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGAX: view
genes like me logo Genes that share phenotypes with ITGAX: view

Animal Models for ITGAX Gene

MGI Knock Outs for ITGAX:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGAX

CRISPR Products

miRNA for ITGAX Gene

miRTarBase miRNAs that target ITGAX

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAX
  • Applied Biological Materials Clones for ITGAX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAX Gene

Localization for ITGAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAX Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGAX gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
cytoskeleton 2
nucleus 2
lysosome 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009986 cell surface IDA 19234460
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITGAX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAX Gene

Pathways & Interactions for ITGAX Gene

genes like me logo Genes that share pathways with ITGAX: view

SIGNOR curated interactions for ITGAX Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2303426
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0009887 animal organ morphogenesis TAS 3327687
GO:0030198 extracellular matrix organization TAS --
GO:0034113 heterotypic cell-cell adhesion IMP 20563599
genes like me logo Genes that share ontologies with ITGAX: view

Drugs & Compounds for ITGAX Gene

(9) Drugs for ITGAX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for ITGAX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGAX: view

Transcripts for ITGAX Gene

Unigene Clusters for ITGAX Gene

Integrin, alpha X (complement component 3 receptor 4 subunit):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAX
  • Applied Biological Materials Clones for ITGAX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ITGAX Gene

GeneLoc Exon Structure for
ITGAX
ECgene alternative splicing isoforms for
ITGAX

Expression for ITGAX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGAX Gene

mRNA differential expression in normal tissues according to GTEx for ITGAX Gene

This gene is overexpressed in Whole Blood (x33.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for ITGAX Gene

This gene is overexpressed in Lymph node (18.9), Monocytes (15.7), and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAX Gene



Protein tissue co-expression partners for ITGAX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAX Gene:

ITGAX

SOURCE GeneReport for Unigene cluster for ITGAX Gene:

Hs.248472

mRNA Expression by UniProt/SwissProt for ITGAX Gene:

P20702-ITAX_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes.

Evidence on tissue expression from TISSUES for ITGAX Gene

  • Blood(4.7)
  • Liver(4.4)
  • Spleen(4.1)
  • Lymph node(4)
  • Bone marrow(3.4)
  • Intestine(3)
  • Lung(2.9)
  • Skin(2.5)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ITGAX: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAX Gene

Orthologs for ITGAX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAX 33 34
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia ITGAX 33 34
  • 81.47 (n)
mouse
(Mus musculus)
Mammalia Itgax 33 16 34
  • 76.94 (n)
rat
(Rattus norvegicus)
Mammalia Itgax 33
  • 76.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32n7.4 34
  • 36 (a)
ManyToMany
Species where no ortholog for ITGAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAX Gene

ENSEMBL:
Gene Tree for ITGAX (if available)
TreeFam:
Gene Tree for ITGAX (if available)

Paralogs for ITGAX Gene

(5) SIMAP similar genes for ITGAX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ITGAX Gene

genes like me logo Genes that share paralogs with ITGAX: view

Variants for ITGAX Gene

Sequence variations from dbSNP and Humsavar for ITGAX Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000145527 -- 31,376,223(+) CCATT(A/G)TAAGA intron-variant
rs1000200595 -- 31,373,783(+) TTTCA(A/G)CTTCG intron-variant
rs1000211681 -- 31,368,603(+) TATTT(A/T)TTTTT intron-variant
rs1000391622 -- 31,370,154(+) TTTCA(C/T)CATGT intron-variant
rs1000404770 -- 31,379,529(+) GCCCC(A/G)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAX Gene

Variant ID Type Subtype PubMed ID
dgv503e214 CNV gain 21293372
esv2714194 CNV deletion 23290073
nsv1059610 CNV gain 25217958
nsv1061980 CNV gain 25217958
nsv833194 CNV loss 17160897

Variation tolerance for ITGAX Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAX Gene

Disorders for ITGAX Gene

MalaCards: The human disease database

(12) MalaCards diseases for ITGAX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
benign cephalic histiocytosis
histiocytosis
  • chronic histiocytosis x
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
mantle cell lymphoma
  • lymphoma, mantle cell
- elite association - COSMIC cancer census association via MalaCards
Search ITGAX in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAX

Genetic Association Database (GAD)
ITGAX
Human Genome Epidemiology (HuGE) Navigator
ITGAX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAX
genes like me logo Genes that share disorders with ITGAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAX Gene

Publications for ITGAX Gene

  1. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PMID: 15730520) Hellmig S … Schreiber S (Tissue antigens 2005) 3 22 45 60
  2. Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PMID: 2303426) Corbi AL … Springer TA (The Journal of biological chemistry 1990) 2 3 4 60
  3. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 45 60
  4. Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. (PMID: 19800635) Brummett BH … Williams RB (Journal of psychiatric research 2010) 3 22 60
  5. Structure of an integrin with an alphaI domain, complement receptor type 4. (PMID: 20033057) Xie C … Springer TA (The EMBO journal 2010) 3 4 60

Products for ITGAX Gene

  • Addgene plasmids for ITGAX

Sources for ITGAX Gene

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