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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGAX Gene

protein-coding GIFtS: 63
GCID: GC16P031366

integrin, alpha X (complement component 3 receptor 4 subunit)

(Previous names: integrin, alpha X (antigen CD11C (p150), alpha polypeptide)...)
(Previous symbol: CD11C)

Explore 47 diseases affiliated with
ITGAX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit)¹ ²		Integrin Alpha-X²
CD11C¹ ² ³ ⁵		Leu M5, Alpha Subunit²
Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide)¹ ²		Leukocyte Surface Antigen P150,95, Alpha Subunit²
Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain² ³		Myeloid Membrane Antigen, Alpha Subunit²
Leukocyte Adhesion Receptor P150,95² ³		P150 95 Integrin Alpha Chain²
CD11 Antigen-Like Family Member C² ³		CD11c Antigen³
CD11c¹		Leu M5³
SLEB6²

External Ids:	HGNC: 6152¹	Entrez Gene: 3687²	Ensembl: ENSG00000140678⁷	OMIM: 151510⁵	UniProtKB: P20702³

Export aliases for ITGAX gene to outside databases

Previous GC identifers: GC16P030448 GC16P031863 GC16P031363 GC16P031402 GC16P031274 GC16P028926

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAX:

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed

of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific

integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the

properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium

cells, and in the phagocytosis of complement coated particles. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702

Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It

mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and

chemotaxis

Gene Wiki entry for ITGAX (CD11c)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGAX gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F Sp1 NRSF form 1 c-Myb E2F-2 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGAX promoter sequence

Search SABiosciences Chromatin IP Primers for ITGAX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

ITGAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAX gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P031366: view genomic region (about GC identifiers)

Start:	31,366,455 bp from pter	End:	31,394,318 bp from pter
Size:	27,864 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702 (See protein sequence)

Recommended Name: Integrin alpha-X precursor

Size: 1163 amino acids; 127829 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2

Subcellular location: Membrane; Single-pass type I membrane protein

5 PDB 3D structures from and Proteopedia for ITGAX:

1N3Y (3D)

2LUV (3D)

3K6S (3D)

3K71 (3D)

3K72 (3D)

Secondary accessions: Q8IVA6

Explore the universe of human proteins at neXtProt for ITGAX: NX_P20702

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20702

ITGAX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000878.2

ENSEMBL proteins:

ENSP00000268296 ENSP00000454623

Reactome Protein details: P20702
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ITGAX (Integrin alpha X/CD11c, Integrin alpha X beta 2)
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ITGAX
	GenScript Custom Purified and Recombinant Proteins Services for ITGAX
	Novus Biologicals ITGAX Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

ITGAX for ontologies About GeneDecksing

ITGAX Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAX
	R&D Systems Antibodies for ITGAX (Integrin alpha X/CD11c)
	OriGene Antibodies (see all 3): ITGAX OriGene Custom Antibody Services for ITGAX
	GenScript Custom Superior Antibodies Services for ITGAX
	Novus Biologicals ITGAX Antibodies
	Abcam antibodies for ITGAX
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ITGAX

Assay Products for ITGAX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for ITGAX (Integrin alpha X/CD11c)
	GenScript Custom Assay Services for ITGAX
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGAX for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P20702

ProtoNet protein and cluster: P20702

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702

Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It

mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and

chemotaxis

Genatlas biochemistry entry for ITGAX:

integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,dimerizing with ITGB2 in fibrinogen,C3b receptor

miRNA Products:		OriGene 3'-UTR Clone: ITGAX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAX
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAX:
		hsa-miR-3613-3p hsa-miR-3908 hsa-miR-2113
		SwitchGear 3'UTR luciferase reporter plasmid: ITGAX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAX (see all 4) OriGene shRNA RFP: ITGAX OriGene siRNA: ITGAX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAX

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGAX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAX (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAX OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGAX (NM_000887)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGAX
		Search LifeMap BioReagents cell lines for ITGAX

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAX

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	2303426
GO:0005515	protein binding	IPI	17726152
GO:0046872	metal ion binding	IEA	--

ITGAX for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Itgax^tm1Bll for ITGAX
     5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Itgax):

cellular

hematopoietic system

immune system

no phenotypic analysis

normal

ITGAX for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Immune response_Alternative complement pathway

	Immune response Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response_Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for ITGAX

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Immune response Lectin Induced complement pathway

5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAX (see all 35)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

3 GeneGo (Thomson Reuters) Pathways for ITGAX

	Immune response Alternative complement pathway
	Immune response Classical complement pathway
	Immune response Lectin induced complement pathway

2 BioSystems Pathways for ITGAX

	Integrin-mediated cell adhesion
	Focal Adhesion

4 Reactome Pathways for ITGAX

	Hemostasis
	Integrin cell surface interactions
	Signal Transduction
	Cell surface interactions at the vascular wall

2 Kegg Pathways (Kegg details for ITGAX):

	Regulation of actin cytoskeleton
	Tuberculosis

ITGAX for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGAX

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/46 Interacting proteins for ITGAX (P20702³ ENSP00000268296⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=4 STRING: ENSP00000303242
C3	P01024³, ENSP00000245907⁴	I2D: score=3 STRING: ENSP00000245907
JAM3	Q9BX67³, ENSP00000299106⁴	I2D: score=1 STRING: ENSP00000299106
FCER2	P06734³, ENSP00000264072⁴	I2D: score=2 STRING: ENSP00000264072
CEBPA	P49715³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0009887	organ morphogenesis	TAS	3327687
GO:0050900	leukocyte migration	TAS	--

ITGAX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGAX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGAX
10/19 Novoseek chemical compound relationships for ITGAX gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp	53.7	3	1680065 (1), 7669656 (1), 12610322 (1)
phorbol-12-myristate	53	3	8649405 (1), 9360988 (1)
n-formylmethionyl-leucylphenylalanine	44.7	1	1680065 (1)
phorbol	39.5	3	8649434 (1), 8649405 (1)
pdtc	30.4	3	8631910 (2)
retinoic acid	28.3	10	17561254 (3), 10641747 (1), 9067636 (1), 16764927 (1) (see all 5)
fibrinogen	22.5	2	7669656 (1), 12393714 (1)
cytochalasin d	16.2	2	7669656 (2)
cycloheximide	15.2	2	9160089 (1), 7739574 (1)
ornithine	14.1	1	1673351 (1)

Search CenterWatch for drugs/clinical trials and news about ITGAX / ITAX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGAX gene:

NM_000887.3

Unigene Cluster for ITGAX:

Integrin, alpha X (complement component 3 receptor 4 subunit)

Hs.248472 [show with all ESTs]

Unigene Representative Sequence: NM_000887

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000564308 ENST00000268296(uc002ebt.3 uc002ebu.1) ENST00000562918

ENST00000567409(uc010cao.1) ENST00000562522(uc010vfk.1) ENST00000571644

ENST00000562138

miRNA Products:		OriGene 3'-UTR Clone: ITGAX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAX
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAX:
		hsa-miR-3613-3p hsa-miR-3908 hsa-miR-2113
		SwitchGear 3'UTR luciferase reporter plasmid: ITGAX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAX (see all 4) OriGene shRNA RFP: ITGAX OriGene siRNA: ITGAX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAX (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAX OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGAX (NM_000887)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGAX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGAX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAX

Additional cDNA sequence:

AK293367.1 AK296666.1 AK309642.1 BC038237.1 M81695.1

13 DOTS entries:

DT.95262776 DT.411782 DT.95262956 DT.120664138 DT.101972447 DT.102822469 DT.120664143 DT.120664150

DT.95177642 DT.97821814 DT.99964818 DT.100672898 DT.97785802

24/45 AceView cDNA sequences (see all 45):

AW206231 CD369592 NM_000887 BC037577 AA258227 BC038237 AW014280 BG427526

CA308944 BM923194 M81695 AA259072 BP361262 AI950296 AW968280 AW196330

AA251543 N28267 AI963970 AA251501 AI144342 AA765843 BQ312815 CA437454

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^
SP1:									-																												-
SP2:									-																												-
SP3:																																															-
SP4:
SP5:

ExUns:	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	^	32
SP1:																							-
SP2:
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for ITGAX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGAX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTATTTTTT

About this image

ITGAX expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Monocyte-like cells (Derivation of dendri...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITGAX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGAX

SOURCE GeneReport for Unigene cluster: Hs.248472

UniProtKB/Swiss-Prot: ITAX_HUMAN, P20702

Tissue specificity: Predominantly expressed in monocytes and granulocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGAX (see all 6):

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Focal Adhesions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGAX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGAX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAX

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGAX gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	47(a) 46(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343220.1(2391221-2422669) GL343220.1(2431120-2468441)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-32n7.4⁶	si:dkey-32n7.4	36(a)	1 → many	12(4794914-4825546)
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ scb⁶ (see all 3)	scab (see all 3)	19(a) 17(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11136290-11146003)

ENSEMBL Gene Tree for ITGAX (if available)
TreeFam Gene Tree for ITGAX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGAX gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA2²

ITGA5² ITGAE² ITGAD² ITGA2B² ITGAV² ITGAL² ITGA9² ITGA4²

ITGA10²

5 SIMAP similar genes for ITGAX using alignment to 2 protein entries: ITAX_HUMAN (see all proteins):

FLJ00114 ITGAD ITGAM ITGA2 ITGAL

ITGAX for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ITGAX
PGOHUM00000248808

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112893030^1,2	F	--	28924776(+)	`AGATGC/TCCTCT`	1	--	us2k¹		2	CSA	4
rs74015508^1,2	C,	--	28925028(+)	`TCCTCC/TTCCAT`	1	--	us2k¹		2	WA	120
rs71391210^1,2	C,F,	--	28925229(+)	`GATCAC/TGAGGT`	1	--	us2k¹		2	NA CSA	4
rs77493918^1,2	C,F,	--	28926391(+)	`CTCCTA/GGGGAC`	1	--	us2k¹		1	WA	118
rs74015509^1,2	C,	--	28926621(+)	`TCTGAT/CGAGAG`	1	--	us2k¹		3	WA CSA	121
rs74015510^1,2	C,F,	--	28927104(+)	`TCTCTG/ATACTG`	1	--	int¹		3	WA CSA	122
rs114050460^1,2	C,F,	--	28928060(+)	`AATCCC/GTTCCA`	1	--	int¹		1	WA	118
rs114590772^1,2	C,F,	--	28928129(+)	`GGAACG/ACAAAC`	1	--	int¹		1	WA	118
rs11574634^1,2	H	--	28928561(+)	`ACAGCC/TTTCTC`	1	--	int¹		5	NA NS EA	460
rs11574636^1,2	C,F,H,	--	28929091(+)	`TGCTGC/TCCGCA`	1	--	int¹		23	NA NS EA WA CSA	1547

HapMap Linkage Disequilibrium report for ITGAX (31366455 - 31394318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ITGAX: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGAX

DNA2.0 Custom Variant and Variant Library Synthesis for ITGAX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ITGAX for disorders           About GeneDecksing

OMIM gene information: 151510    OMIM disorders: --

20/47 diseases for ITGAX (see all 47):    About MalaCards

human t-cell leukemia virus type 1 polyclonal hypergammaglobulinemia proliferative vitreoretinopathy venous insufficiency

sporotrichosis splenomegaly hairy cell leukemia chronic granulomatous disease

obstructive jaundice systemic mastocytosis mastocytosis systemic lupus erythematosus

acute promyelocytic leukemia lupus erythematosus vitreoretinopathy vasculitis

lymphocytic vasculitis jaundice hypergammaglobulinemia chronic lymphocytic leukemia

1 disease from the University of Copenhagen DISEASES database for ITGAX:

Hairy cell leukemia

10/11 Novoseek disease relationships for ITGAX gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia hairy cell	60.9	1	12576324 (1)
lymphoproliferative disorders	21.8	1	10721778 (1)
splenomegaly	15.8	1	2234204 (1)
inflammation	12	3	14688376 (1), 19702851 (1), 11151969 (1)
leukemia	10.8	4	1689668 (2), 17561254 (1), 2328771 (1)
colitis ulcerative	0.886	1	9473377 (1)
acute leukemia	0	1	9658721 (1)
lymphoma non-hodgkins	0	1	10979212 (1)
lymphoma	0	1	11937543 (1)
preeclampsia	0	2	11799095 (2)

Genetic Association Database (GAD): ITGAX
Human Genome Epidemiology (HuGE) Navigator: ITGAX (5 documents)

Export disorders for ITGAX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITGAX gene, integrated from 9 sources (see all 258):
(articles sorted by number of sources associating them with ITGAX)

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Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PubMed id 2303426)^{1, 2, 3} Corbi A.L.... Springer T.A. (1990)
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)^{1, 4, 9} Hellmig S....Schreiber S. (2005)
Structure of an integrin with an alphaI domain, compl ement receptor type 4. (PubMed id 20033057)^{1, 2} Xie C....Springer T.A. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. (PubMed id 3284962)^{1, 3} Corbi A.L....Morton C.C. (1988)
Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins. (PubMed id 3549901)^{1, 2} Miller L.J.... Springer T.A. (1987)
cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. (PubMed id 3327687)^{1, 2} Corbi A.L.... Springer T.A. (1987)
Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells. (PubMed id 16716806)^{1, 9} Lee T.J....Kwon T.K. (2006)
CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. (PubMed id 12576324)^{1, 9} Nicolaou F....Shelley C.S. (2003)
CD11c integrin gene promoter activity during myeloid differentiation. (PubMed id 9250811)^{1, 9} Corbi A.L. and Lopez-Rodriguez C. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3687	HGNC: 6152	AceView: ITGAX	Ensembl:ENSG00000140678	euGenes: HUgn3687
ECgene: ITGAX	Kegg: 3687	H-InvDB: ITGAX

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ITGAX	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGAX	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGAX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGAX gene:
Search GeneIP for patents involving ITGAX

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ITGAX Gene

integrin, alpha X (complement component 3 receptor 4 subunit)

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ITGAX Gene

integrin, alpha X (complement component 3 receptor 4 subunit)

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