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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGAV Gene

protein-coding GIFtS: 69
GCID: GC02P187418

integrin, alpha V

(Previous names: antigen identified by monoclonal antibody L230, vitronectin...)
(Previous symbols: VNRA, MSK8, VTNR)

Explore 87 diseases affiliated with
ITGAV via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha V¹ ²		Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51)¹ ²
VNRA¹ ² ³ ⁵		Vitronectin Receptor Subunit Alpha² ³
MSK8¹ ² ³		Vitronectin Receptor¹
CD51¹ ²		Integrin Alpha-V²
VTNR¹ ²		Integrin AlphaVbeta3²
Antigen Identified By Monoclonal Antibody L230¹ ²		CD51 Antigen³

External Ids:	HGNC: 6150¹	Entrez Gene: 3685²	Ensembl: ENSG00000138448⁷	OMIM: 193210⁵	UniProtKB: P06756³

Export aliases for ITGAV gene to outside databases

Previous GC identifers: GC02P185662 GC02P186138 GC02P187657 GC02P187280 GC02P187163 GC02P179314

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAV:

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain

and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield

disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins.

Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'),

each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these,

is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate

signal transduction. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix

metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D

in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to

enhance angiogenesis in Kaposi's sarcoma lesions

Gene Wiki entry for ITGAV

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGAV gene promoter:
FOXF2 Cart-1 FOXO1a IRF-7A Ik-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGAV promoter sequence

Search SABiosciences Chromatin IP Primers for ITGAV

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAV

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31-q32 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q31-q32

ITGAV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAV gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P187418: view genomic region (about GC identifiers)

Start:	187,454,790 bp from pter	End:	187,545,628 bp from pter
Size:	90,839 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756 (See protein sequence)

Recommended Name: Integrin alpha-V precursor

Size: 1048 amino acids; 116038 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked

by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with

HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this

virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a

receptor for these viruses. Interacts with RAB25

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAD93131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

6/7 PDB 3D structures from and Proteopedia for ITGAV (see all 7):

1JV2 (3D)

1L5G (3D)

1M1X (3D)

1U8C (3D)

3IJE (3D)

4G1E (3D)

Secondary accessions: A0AV67 B0LPF4 B7Z883 D3DPG8 E7EWZ6 Q53SK4 Q59EB7 Q6LD15

Alternative splicing: 3 isoforms: P06756-1 P06756-2 P06756-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGAV: NX_P06756

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06756

ITGAV Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138471.1 NP_001138472.1 NP_002201.1

ENSEMBL proteins:

ENSP00000261023 ENSP00000364042 ENSP00000404291 ENSP00000389442

Reactome Protein details: P06756
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant ITGAV Protein
	R&D Systems Recombinant & Natural Proteins for ITGAV (Integrin alpha V beta 8, Integrin alpha V beta 6, Integrin alpha V beta 3, Integrin alpha V beta 5, Integrin alpha V beta 1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): ITGAV OriGene Custom Protein Services for ITGAV
	GenScript Custom Purified and Recombinant Proteins Services for ITGAV
	Novus Biologicals ITGAV Proteins Novus Biologicals ITGAV Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	11877390
GO:0008305	integrin complex	NAS	11877390
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	ISS	--

ITGAV for ontologies About GeneDecksing

ITGAV Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAV
	R&D Systems Antibodies for ITGAV (Integrin alpha V beta 3, Integrin alpha V beta 5, Integrin alpha V/CD51)
	Cell Signaling Technology (CST) Antibodies for ITGAV
	OriGene Antibodies: ITGAV OriGene Custom Antibody Services for ITGAV
	GenScript Custom Superior Antibodies Services for ITGAV
	Novus Biologicals ITGAV Antibodies
	Abcam antibodies for ITGAV
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ITGAV

Assay Products for ITGAV:

	EMD Millipore Kits and Assays for the Analysis of ITGAV
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for ITGAV (Integrin alpha V beta 3) (see all)
	GenScript Custom Assay Services for ITGAV
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGAV for domains About GeneDecksing

5 InterPro domains/families:

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P06756

ProtoNet protein and cluster: P06756

3 Blocks protein families:

IPB000413 Integrins alpha chain

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix

metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D

in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to

enhance angiogenesis in Kaposi's sarcoma lesions

Genatlas biochemistry entry for ITGAV:

integrin,alpha V,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand

factor,thrombospondin,fibronectin,osteopontin,collagen receptors;with ITGB1 or ITGB5 in vitronectin receptor;with

ITGB6 in fibronectin receptor

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ITGAV Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAV
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAV (see all 41):
		hsa-miR-142-5p hsa-miR-300 hsa-miR-146a hsa-miR-25 hsa-let-7a-2* hsa-miR-4325 hsa-miR-520g hsa-miR-1183

		SwitchGear 3'UTR luciferase reporter plasmid: ITGAV 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAV (see all 7) OriGene shRNA RFP: ITGAV OriGene siRNA: ITGAV
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAV

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGAV

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): ITGAV (NM_002210)
		Sino Biological Human cDNA Clone for ITGAV
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGAV
		Search LifeMap BioReagents cell lines for ITGAV

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAV

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001846	contributes to opsonin binding	ISS	--
GO:0004872	receptor activity	--	--
GO:0005080	contributes to protein kinase C binding	ISS	--
GO:0005245	voltage-gated calcium channel activity	IDA	18395422
GO:0005515	protein binding	IPI	--

ITGAV for ontologies About GeneDecksing

10 GenomeRNAi human phenotypes for ITGAV:

Decreased focal adhesion (FA)	Decreased viability of wild-ty	Increased Salmonella enterica	Increased Salmonella enterica
Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella-containin
Increased cell death HMECs cel	Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for ITGAV: Itgav^tm1Hyn Itgav^tm2.1Hyn
15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Itgav) (see all 16):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	muscle	nervous system	renal/urinary system

ITGAV for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility	0.32
Cytoskeleton remodeling Integrin outside-in signaling	0.37	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	0.32	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Signal transduction by L1	0.12

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for ITGAV

	Cytoskeleton remodeling Integrin outside-in signaling
	Development VEGF-family signaling
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Cell adhesion Integrin inside-out signaling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAV (see all 35)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

2 Cell Signaling Technology (CST) Pathways for ITGAV

	Angiogenesis
	Adhesion

2 Tocris Bioscience Pathways for ITGAV

	NF-kappaB Pathway
	MAPK Pathway

5/6 GeneGo (Thomson Reuters) Pathways for ITGAV (see all 6)

	Development VEGF-family signaling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Development VEGF signaling via VEGFR2 - generic cascades
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin inside-out signaling

5/12 BioSystems Pathways for ITGAV (see all 12)

	Focal Adhesion
	Integrin-mediated cell adhesion
	Arrhythmogenic right ventricular cardiomyopathy
	PDGFR-alpha signaling pathway
	S1P3 pathway

5/17 Reactome Pathways for ITGAV (see all 17)

	L1CAM interactions
	Developmental Biology
	Elastic fibre formation
	Signal transduction by L1
	Molecules associated with elastic fibres

1 PharmGKB Pathway for ITGAV

VEGF Signaling Pathway

5/10 Kegg Pathways (Kegg details for ITGAV) (see all 10):

	Phagosome
	Focal adhesion
	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Regulation of actin cytoskeleton

ITGAV for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGAV

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/176 Interacting proteins for ITGAV (P06756^{1, 2, 3} ENSP00000261023⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 176)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB5	P18084¹^,³, ENSP00000296181⁴	EBI-298282,EBI-1223434 I2D: score=4 STRING: ENSP00000296181
ITGB3	P05106¹^,²^,³, ENSP00000262017⁴	EBI-298282,EBI-702847 MINT-8216018 MINT-8216025 MINT-25081 I2D: score=5 STRING: ENSP00000262017
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=3 STRING: ENSP00000364094
ANGPTL3	Q9Y5C1³, ENSP00000360170⁴	I2D: score=2 STRING: ENSP00000360170
CALR	P27797³, ENSP00000320866⁴	I2D: score=2 STRING: ENSP00000320866

About this table

Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEP	11866539
GO:0001568	blood vessel development	--	--
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0007155	cell adhesion	IDA	10218736

ITGAV for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGAV for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGAV

1 DrugBank Compound for ITGAV About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Antithymocyte globulin	rabbit ATG (see all 3)	--	target	--	12586600

8 Novoseek chemical compound relationships for ITGAV gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
penton	82.3	9	9930328 (2), 9135136 (1), 7533853 (1), 8837891 (1) (see all 7)
lm 609	67.8	2	12901232 (1), 12379637 (1)
fibrinogen	31.4	2	9033403 (2)
vegf	30.8	15	18854653 (5), 16496302 (2), 19212638 (2), 16598467 (1) (see all 6)
calcium	3.66	1	17158881 (1)
titanium	1.36	1	10817264 (1)
tyrosine	0	2	17228150 (1)
hydroxyapatite	0	2	10817264 (1), 18780564 (1)

Search CenterWatch for drugs/clinical trials and news about ITGAV / ITAV

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGAV gene (3 alternative transcripts):

NM_001144999.1 NM_001145000.1 NM_002210.3

Unigene Cluster for ITGAV:

Integrin, alpha V

Hs.436873 [show with all ESTs]

Unigene Representative Sequence: NM_002210

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261023(uc002upq.3 uc010frs.3 uc010zfv.2) ENST00000374907

ENST00000433736 ENST00000460641 ENST00000496477 ENST00000496854 ENST00000474571

ENST00000430709

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAV
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAV (see all 41):
		hsa-miR-142-5p hsa-miR-300 hsa-miR-146a hsa-miR-25 hsa-let-7a-2* hsa-miR-4325 hsa-miR-520g hsa-miR-1183

		SwitchGear 3'UTR luciferase reporter plasmid: ITGAV 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAV (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAV (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ITGAV (NM_002210)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAV
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAV

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAV
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAV

Additional cDNA sequence:

AB209894.1 AK302550.1 AK302990.1 AK309711.1 BC047454.1 BC072686.1 BC126231.1 BC136442.1

BC144100.1 EF560727.1 M14648.1

11 DOTS entries:

DT.99956906 DT.91755266 DT.100795812 DT.91755262 DT.100795820 DT.75107177 DT.120970004 DT.91850420

DT.95191020 DT.120969933 DT.120969966

24/305 AceView cDNA sequences (see all 305):

AA962495 BM984332 AL707747 NM_002210 AI285412 BU742606 BX477489 AI702361

BU681894 AA587812 AI953758 BC072686 BG260819 AA320843 BM786564 BU629798

AA214606 CB044028 BM830812 AW341935 AA307350 AI362557 CD676605 CA396552

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAV About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:
SP2:											-		-

ExUns:	26	^	27	^	28	^	29	^	30
SP1:
SP2:

ECgene alternative splicing isoforms for ITGAV

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGAV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTTGTGA

About this image

ITGAV expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Gut Tube

Midgut

Gut Tube

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Epithelial Podocyte-like cells (Induction of mesench...)

See ITGAV Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGAV

SOURCE GeneReport for Unigene cluster: Hs.436873

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGAV (see all 10):

Osteogenesis in human mouse rat

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

Cell Junction PathwayFinder in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGAV gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGAV¹	integrin, alpha V (vitronectin receptor, alpha polypeptide, more	78.01(n) 83.04(a)		396420 NM_205439.1 NP_990770.1
lizard (Anolis carolinensis)	Reptilia	ITGAV⁶	--	78(a)	1 ↔ 1	GL343737.1(30388-112534)
African clawed frog (Xenopus laevis)	Amphibia	LOC397997²	integrin alphaV subunit	76.25(n)		U92006.1
zebrafish (Danio rerio)	Actinopterygii	itgav¹	integrin, alpha V	62.71(n) 61.56(a)		100151255 NM_001033721.1 NP_001028893.1
fruit fly (Drosophila melanogaster)	Insecta	if^{1 , 3}	maintenance of protein localization cell adhesion more³ inflated¹	31(a) (best of 4)³ 45.34(n)¹ 33.75(a)¹		32661¹ NM_078654.2¹ NP_523378.2¹
worm (Caenorhabditis elegans)	Secernentea	F54F2.1³	Vitronectin receptor alpha subunit	30(a) (best of 2)		III(8890624-8896700) --

ENSEMBL Gene Tree for ITGAV (if available)
TreeFam Gene Tree for ITGAV (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGAV gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA2²

ITGA5² ITGAE² ITGAD² ITGA2B² ITGAX² ITGAL² ITGA9² ITGA4²

ITGA10²

4 SIMAP similar genes for ITGAV using alignment to 5 protein entries: ITAV_HUMAN (see all proteins):

ITGA8 ITGA5 ITGA2B ITGA4

ITGAV for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183191755^1,2		--	187452806(+)	`CTTTGA/GTGTAT`	2	--	us2k¹		0	--	--	--	--
rs187828336^1,2		--	187452822(+)	`AAGAAA/GGTGAG`	2	--	us2k¹		0	--	--	--	--
rs6739787^1,2	C,F,H,	--	187452875(+)	`ATTTCC/TTCTCT`	2	--	us2k¹ trp³		25		NS EA NA WA CSA	1888
rs139057847^1,2	C,	--	187452988(+)	`ATGCA-/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs191974665^1,2		--	187453111(+)	`GAGTAC/GCTGGG`	2	--	us2k¹		0	--	--	--	--
rs146255137^1,2		--	187453138(+)	`GCCACA/GCCCGG`	2	--	us2k¹		0	--	--	--	--
rs139605375^1,2		--	187453224(+)	`AATTTA/GCCGGC`	2	--	us2k¹		0	--	--	--	--
rs144325150^1,2		--	187453225(+)	`ATTTGA/CCGGCC`	2	--	us2k¹		0	--	--	--	--
rs150647110^1,2		--	187453227(+)	`TTGCCA/GGCCTC`	2	--	us2k¹		0	--	--	--	--
rs182896541^1,2		--	187453276(+)	`TCGCCC/TGGCCT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ITGAV (187454790 - 187545628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ITGAV
3 CNVs: 9438 3403 2419

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGAV for disorders           About GeneDecksing

OMIM gene information: 193210    OMIM disorders: --

20/87 diseases for ITGAV (see all 87):    About MalaCards

localized scleroderma arteriovenous malformation primary biliary cirrhosis squamous cell carcinoma

cavernous malformation mouth disease laryngeal squamous cell carcinoma chorioangioma

cutaneous malignant melanoma oral squamous cell carcinoma cytomegalovirus infection inflammatory bowel disease

priapism sickle cell disease rheumatoid arthritis basal cell carcinoma

chronic lymphocytic leukemia acute myeloid leukemia epithelial ovarian cancer lymphocytic leukemia

10/27 Novoseek disease relationships for ITGAV gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenovirus infections	40.3	3	7533853 (2), 9930328 (1)
metastasis	32.8	20	18427826 (4), 12629984 (2), 16631833 (1), 18794119 (1) (see all 11)
tumors	29.4	23	18357713 (3), 9159820 (2), 12901232 (1), 7538977 (1) (see all 17)
lung carcinoma	22.4	2	9354507 (1), 16569454 (1)
osteosarcoma	21.2	10	18854653 (6), 10429943 (2)
carcinoma lobular	21.1	3	8548120 (2), 7680285 (1)
colon carcinoma	20.8	1	9223381 (1)
cancer	19.5	8	18427826 (2), 18357713 (2), 17786296 (1), 17955485 (1) (see all 5)
melanoma	15.8	7	1285050 (1), 7538977 (1), 1376331 (1), 8641196 (1) (see all 5)
breast carcinoma	13.4	2	8548120 (2)

Human Genome Epidemiology (HuGE) Navigator: ITGAV (14 documents)

Export disorders for ITGAV gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGAV gene, integrated from 9 sources (see all 541):
(articles sorted by number of sources associating them with ITGAV)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. (PubMed id 10965141)^{1, 2, 9} Sims M.A.... Campbell D.A. (2000)
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PubMed id 17925226)^{1, 2} Caswell P.T....Norman J.C. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. (PubMed id 15194773)^{1, 2} Williams C.H....Stanway G. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. (PubMed id 14596610)^{1, 2} Krokhin O.V....Wilkins J.A. (2003)
Crystal structure of the extracellular segment of integrin alpha Vbeta3. (PubMed id 11546839)^{1, 2} Xiong J.P.... Arnaout M.A. (2001)
The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. (PubMed id 10397733)^{1, 2} Barillari G.... Ensoli B. (1999)
The integrin alpha v gene: identification and characterization of the promoter region. (PubMed id 7522056)^{1, 2} Donahue J.P.... Hawiger J. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3685	HGNC: 6150	AceView: ITGAV	Ensembl:ENSG00000138448	euGenes: HUgn3685
ECgene: ITGAV	Kegg: 3685	H-InvDB: ITGAV

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGAV	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGAV	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGAV gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGAV gene:
Search GeneIP for patents involving ITGAV

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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