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Aliases for ITGAV Gene

Aliases for ITGAV Gene

  • Integrin, Alpha V 2 3
  • VNRA 3 4 6
  • Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51) 2 3
  • Antigen Identified By Monoclonal Antibody L230 2 3
  • Vitronectin Receptor Subunit Alpha 3 4
  • MSK8 3 4
  • Vitronectin Receptor 2
  • Integrin AlphaVbeta3 3
  • Integrin Alpha-V 3
  • CD51 Antigen 4
  • CD51 3
  • VTNR 3

External Ids for ITGAV Gene

Previous Symbols for ITGAV Gene

  • VNRA
  • MSK8
  • VTNR

Summaries for ITGAV Gene

Entrez Gene Summary for ITGAV Gene

  • This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]

GeneCards Summary for ITGAV Gene

ITGAV (Integrin, Alpha V) is a Protein Coding gene. Diseases associated with ITGAV include chorioangioma and cerebral hypoxia. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include protein kinase C binding and virus receptor activity. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAV Gene

  • The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions

Gene Wiki entry for ITGAV Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAV Gene

Genomics for ITGAV Gene

Genomic Location for ITGAV Gene

186,589,645 bp from pter
186,680,902 bp from pter
91,258 bases
Plus strand

Genomic View for ITGAV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGAV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAV Gene

Regulatory Elements for ITGAV Gene

Proteins for ITGAV Gene

  • Protein details for ITGAV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrin alpha-V
    Protein Accession:
    Secondary Accessions:
    • A0AV67
    • B0LPF4
    • B7Z883
    • B7ZLX0
    • D3DPG8
    • E7EWZ6
    • Q53SK4
    • Q59EB7
    • Q6LD15

    Protein attributes for ITGAV Gene

    1048 amino acids
    Molecular mass:
    116038 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. lpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with CIB1 (PubMed:24011356). Interacts with RAB25 (PubMed:17925226). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). Interacts with HIV-1 Tat (PubMed:10397733). Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus.
    • Sequence=BAD93131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGAV Gene

    Alternative splice isoforms for ITGAV Gene


neXtProt entry for ITGAV Gene

Proteomics data for ITGAV Gene at MOPED

Post-translational modifications for ITGAV Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys233 and Lys360
  • Glycosylation at Asn74, Asn290, Asn296, Asn488, Asn554, Asn615, Asn704, Asn835, Asn851, Asn874, Asn945, Asn973, and Asn980

Other Protein References for ITGAV Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGAV Gene

Domains for ITGAV Gene

Gene Families for ITGAV Gene

  • CD :CD molecules
  • ITG :Integrins


  • Belongs to the integrin alpha chain family.:
    • P06756
  • Contains 7 FG-GAP repeats.:
    • P06756
genes like me logo Genes that share domains with ITGAV: view

Function for ITGAV Gene

Molecular function for ITGAV Gene

GENATLAS Biochemistry: integrin,alpha V,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand factor,thrombospondin,fibronectin,osteopontin,collagen receptors;with ITGB1 or ITGB5 in vitronectin receptor;with ITGB6 in fibronectin receptor
UniProtKB/Swiss-Prot Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions

Gene Ontology (GO) - Molecular Function for ITGAV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001846 contributes_to opsonin binding ISS --
GO:0001968 fibronectin binding IDA 24658351
GO:0002020 protease binding IDA 22505472
GO:0005080 contributes_to protein kinase C binding ISS --
genes like me logo Genes that share ontologies with ITGAV: view
genes like me logo Genes that share phenotypes with ITGAV: view

Animal Models for ITGAV Gene

MGI Knock Outs for ITGAV:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGAV Gene

Localization for ITGAV Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAV Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ITGAV Gene COMPARTMENTS Subcellular localization image for ITGAV gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGAV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 11877390
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex NAS 11877390
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGAV: view

Pathways for ITGAV Gene

genes like me logo Genes that share pathways with ITGAV: view

Gene Ontology (GO) - Biological Process for ITGAV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001568 blood vessel development --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0007155 cell adhesion IDA 10218736
genes like me logo Genes that share ontologies with ITGAV: view

Compounds for ITGAV Gene

(1) Drugbank Compounds for ITGAV Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antithymocyte globulin
  • rabbit ATG

(8) Novoseek inferred chemical compound relationships for ITGAV Gene

Compound -log(P) Hits PubMed IDs
penton 82.3 8
lm 609 67.8 2
fibrinogen 31.4 2
vegf 30.8 12
calcium 3.66 1
genes like me logo Genes that share compounds with ITGAV: view

Transcripts for ITGAV Gene

Unigene Clusters for ITGAV Gene

Integrin, alpha V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAV Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP2: - -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30

Relevant External Links for ITGAV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITGAV Gene

mRNA expression in normal human tissues for ITGAV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGAV Gene

SOURCE GeneReport for Unigene cluster for ITGAV Gene Hs.436873

genes like me logo Genes that share expressions with ITGAV: view

Orthologs for ITGAV Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGAV Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITGAV 36
  • 99.65 (n)
  • 99.9 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ITGAV 36
  • 91.76 (n)
  • 95.39 (a)
  • 95 (a)
(Canis familiaris)
Mammalia ITGAV 36
  • 89.62 (n)
  • 95.13 (a)
  • 93 (a)
(Mus musculus)
Mammalia Itgav 36
  • 87.87 (n)
  • 93.69 (a)
Itgav 16
Itgav 37
  • 93 (a)
(Monodelphis domestica)
Mammalia ITGAV 37
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
-- 37
  • 86 (a)
(Rattus norvegicus)
Mammalia Itgav 36
  • 85.23 (n)
  • 90.21 (a)
(Gallus gallus)
Aves ITGAV 36
  • 78.43 (n)
  • 83.48 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia ITGAV 37
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397997 36
tropical clawed frog
(Silurana tropicalis)
Amphibia itgav 36
  • 70.93 (n)
  • 72.8 (a)
(Danio rerio)
Actinopterygii itgav 36
  • 62.62 (n)
  • 61.26 (a)
itgav 37
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta if 37
  • 23 (a)
if 38
  • 31 (a)
scb 38
  • 24 (a)
alphaPS5 38
  • 22 (a)
alphaPS4 38
  • 23 (a)
(Caenorhabditis elegans)
Secernentea pat-2 37
  • 26 (a)
F54F2.1 38
  • 30 (a)
ina-1 38
  • 24 (a)
Species with no ortholog for ITGAV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGAV Gene

Gene Tree for ITGAV (if available)
Gene Tree for ITGAV (if available)

Paralogs for ITGAV Gene

Selected SIMAP similar genes for ITGAV Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ITGAV: view

Variants for ITGAV Gene

Sequence variations from dbSNP and Humsavar for ITGAV Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13482 -- 186,680,526(-) TAGGC(C/T)TACTA utr-variant-3-prime
rs1031295 -- 186,656,047(-) TTAAT(C/T)AAACT intron-variant
rs1054194 -- 186,679,205(+) CCTAG(C/T)AACAG utr-variant-3-prime
rs1054197 -- 186,679,459(+) AAGAG(C/T)AATTT utr-variant-3-prime
rs1054264 -- 186,680,758(+) CACCC(A/C)CATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ITGAV Gene

Variant ID Type Subtype PubMed ID
dgv1279e1 CNV Complex 17122850
nsv875552 CNV Loss 21882294
dgv1280e1 CNV Complex 17122850
nsv818105 CNV Gain 17921354
esv1634124 CNV Insertion 17803354
esv2721241 CNV Deletion 23290073

Relevant External Links for ITGAV Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ITGAV Gene

(27) Novoseek inferred disease relationships for ITGAV Gene

Disease -log(P) Hits PubMed IDs
adenovirus infections 40.3 3
metastasis 32.8 15
tumors 29.4 20
lung carcinoma 22.4 2
osteosarcoma 21.2 8

Relevant External Links for ITGAV

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ITGAV: view

No data available for UniProtKB/Swiss-Prot for ITGAV Gene

Publications for ITGAV Gene

  1. Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. (PMID: 10965141) Sims M.A. … Campbell D.A. (Cytogenet. Cell Genet. 2000) 3 4 23
  2. The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study. (PMID: 17615072) Jacq L. … CornAclis F. (Arthritis Res. Ther. 2007) 3 23 49
  3. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PMID: 18550570) Brendle A. … FAPrsti A. (Carcinogenesis 2008) 3 23 49
  4. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. (PMID: 17879163) Kamarajan P. … Kapila Y.L. (Apoptosis 2007) 3 23
  5. Quantitative gene-expression of the tumor angiogenesis markers vascular endothelial growth factor, integrin alphaV and integrin beta3 in human neuroendocrine tumors. (PMID: 19212638) Oxboel J. … Kjaer A. (Oncol. Rep. 2009) 3 23

Products for ITGAV Gene

  • Addgene plasmids for ITGAV

Sources for ITGAV Gene

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