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ITGAV Gene

protein-coding GIFtS: 68

GC02P187163

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
(Previous name: antigen identified by monoclonal antibody L230 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: VNRA, MSK8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD51 ^¹, ²
DKFZp686A08142 ^²
MSK8 ^², ³
VNRA ^², ³, ⁵

Descriptions
CD51 antigen ^³
Vitronectin receptor subunit alpha ^³
antigen identified by monoclonal antibody L230 ^¹, ²
integrin alpha-V ^²
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ^²

External Ids
HGNC: 6150¹
Entrez Gene: 3685²
UniProtKB: P06756³
Ensembl: ENSG00000138448⁷

Search outside databases for aliases for ITGAV gene

Previous GC identifers: GC02P185662 GC02P186138 GC02P187418 GC02P187657 GC02P187280

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ITGAV:

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins

composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes

post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with

multiple integrin beta chains to form different integrins. Among the known associating beta chains

(beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5',

'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands;

the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin

receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal

transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen,

laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and

vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the

interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma

lesions

Gene Wiki entry for ITGAV

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ITGAV gene

Entrez Gene cytogenetic band: 2q31-q32 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q31-q32

ITGAV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P187163: (about GC identifiers)

Start:	187,163,045 bp from pter
End:	187,253,873 bp from pter
Size:	90,829 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756 (See protein sequence)

Recommended Name: Integrin alpha-V precursor

Size: 1048 amino acids; 116038 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and

a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5,

beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease

virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6

binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these

viruses

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1JV2 (3D)

1L5G (3D)

1M1X (3D)

1U8C (3D)

Secondary accessions: A0AV67 Q53SK4 Q59EB7 Q6LD15

Alternative splicing: 2 isoforms: P06756-1 P06756-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001138471.1 NP_001138472.1 NP_002201.1

ENSEMBL proteins:

ENSP00000364042 ENSP00000261023

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ITGAV Protein
	Sigma-Aldrich CompoZr ZFN for ITGAV
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Integrin alpha V beta 3, Integrin alpha V, Integrin alpha V+beta 5, CD51 + CD61)
	Human Recombinant Proteins from Abnova (ITGAV)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IDA	18029348
GO:0008305	integrin complex	NAS	11877390
GO:0009897	external side of plasma membrane	IEA	--

About this table

Antibodies for ITGAV:

	Invitrogen Antibodies for ITGAV
	Millipore Mono- and Polyclonal Antibodies for the study of ITGAV
	Sigma-Aldrich Antibodies for ITGAV
	R&D Systems Antibodies for ITGAV (Integrin alpha V/CD51)
	Cell Signaling Technology (CST) Antibodies for ITGAV (integrin alpha5)
	Antibodies from Abcam (Integrin alpha V beta 3, Integrin alpha V, Integrin alpha V+beta 5, CD51 + CD61), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ITGAV)
	Novus Biologicals Antibodies for ITGAV

Assays for ITGAV:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ITGAV
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06756

ProtoNet protein and cluster: P06756

3 Blocks protein families:

IPB000413 Integrins alpha chain

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITGAV)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITGAV)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002210

Applied Biosystems Silencer® siRNAs for ITGAV

Sigma-Aldrich siRNA and siRNA Panels for ITGAV

Sigma-Aldrich shRNA Panels and shRNA for ITGAV

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001144999
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001144999
untagged cDNA clones in CMV expression vector (see all 3): NM_001144999

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002210

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756

Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen,

laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and

vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the

interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma

lesions

Genatlas biochemistry entry for ITGAV:

integrin,alpha V,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or

to other cells,through hetero dimerization and connecting to the cytoskeleton and various

signaling molecules within cells,dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand

factor,thrombospondin,fibronectin,osteopontin,collagen receptors;with ITGB1 or ITGB5 in

vitronectin receptor;with ITGB6 in fibronectin receptor

15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Itgav):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	nervous system	skeleton	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	11877390

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ITGAV (Your Favorite Gene powered by Ingenuity)

NF-&kappa
Integrin Signaling
Caveolar-mediated Endocytosis

GeneDecks ITGAV for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ITGAV

5/171 Interacting proteins for ITGAV (ENSP00000364042³ P06756^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 171 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANGPTL3	Q9Y5C1¹	STRING (score=.961) EBI-298282, EBI-298276
ITGB3	P05106¹^,²	STRING (score=.999) EBI-298282, EBI-702847 MINT-25081 EBI-298282, EBI-702847 MINT-25081
ITGB3	P05106¹^,²	STRING (score=.999) EBI-298282, EBI-702847 MINT-25081 EBI-298282, EBI-702847 MINT-25081
ITGB5	ENSP00000296181³	STRING (score=.999)
VTN	ENSP00000226218³	STRING (score=.999)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0007155	cell adhesion	TAS	2430295
GO:0007160	cell-matrix adhesion	NAS	11877390
GO:0007229	integrin-mediated signaling pathway	NAS	11877390
GO:0010745	negative regulation of foam cell differentiation	IMP	15215180

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ITGAV:

Antagonist

Browse Tocris compounds for ITGAV
7 Novoseek chemical compound relationships for ITGAV gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
penton	82.68	9	9930328 (2), 9135136 (1), 7533853 (1), 8837891 (1) (see all 7)
lm 609	68.17	2	12901232 (1), 12379637 (1)
fibrinogen	32.18	2	9033403 (2)
calcium	3.37	1	17158881 (1)
titanium	3.10	1	10817264 (1)
hydroxyapatite	0.00	2	10817264 (1), 18780564 (1)
tyrosine	0.00	2	17228150 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITGAV)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITGAV)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002210

Sigma-Aldrich siRNA and siRNA Panels for ITGAV

Sigma-Aldrich shRNA Panels and shRNA for ITGAV

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002210

REFSEQ mRNAs for ITGAV gene (3 alternative transcripts):

NM_001144999.1 NM_001145000.1 NM_002210.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002210

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001144999
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001144999
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001144999

Additional cDNA sequence:

AB209894.1 AK302550.1 AK302990.1 AK309711.1 BC047454.1 BC072686.1 BC126231.1 BC136442.1

BC144100.1 EF560727.1 M14648.1

11 DOTS entries:

DT.99956906 DT.91755266 DT.100795812 DT.91755262 DT.100795820 DT.75107177 DT.120969933 DT.120970004

DT.91850420 DT.120969966 DT.95191020

24/305 AceView cDNA sequences (see all 305 ):

CB128487 AU118713 AW778727 AA709042 BX481015 R38032 BQ025424 M14648

AI362557 AW272306 CA396552 BM728668 BQ129340 AA044639 AA307350 AA320843

T29242 BC072686 AW341935 CB044028 CB138635 AA214606 BU742606 BQ024759

highest scoring ESTs for ITGAV:

M14648 AA029934 AA030046 AA044639 AA044703 AA095243 AA098978 AA214606 AA307350 AA313002

Unigene Cluster for ITGAV:

Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Hs.436873 [show with all ESTs]

Unigene Representative Sequence: NM_002210

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAV

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:
SP2:											-		-

ExUns:	26	^	27	^	28	^	29	^	30
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for ITGAV

2 Ensembl transcripts including schematic representations:

ENST00000374907 ENST00000261023

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ITGAV expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ITGAV

¹ / ² / ³

5 probe-sets matching ITGAV gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39071_at²^{, 3}	U95-A	1	1.00	1.00	0.83	1.16	M14648	1.00	1.00	1.00	1
257_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.62	M14648	1.00	1.00	1.00	1
2032_s_at²^{, 3}	U95-A	1	1.00	1.00	0.59	1.23	U07375	0.20	1.00	0.72	1
202351_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI093579	0.80	1.00	0.91	1
202351_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ITGAV for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAACTTGTGA

SOURCE GeneReport for Unigene cluster: Hs.436873
Expression variation in blood from EXPOLDB for ITGAV

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ITGAV gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ITGAV¹	--	integrin, alpha V (vitronectin receptor, alpha polypeptide, more	89.7(n) 95.12(a)	488437 XM_845896.1 XP_850989.1
chimpanzee (Pan troglodytes)	ITGAV¹	--	integrin, alpha V (vitronectin receptor, alpha polypeptide, more	99.65(n) 99.9(a)	459807 XM_515967.2 XP_515967.2
cow (Bos taurus)	ITGAV¹	--	integrin, alpha V (vitronectin receptor, alpha polypeptide, more	91.98(n) 95.51(a)	281875 NM_174367.1 NP_776792.1
rat (Rattus norvegicus)	Itgav¹	--	integrin alpha V	84.64(n) 89.68(a)	296456 XM_230950.4 XP_230950.4
mouse (Mus musculus)	Itgav^{1, 5}	2 (46.00 cM)⁵	integrin alpha V^{1, 5}	87.09(n)¹ 92.33(a)¹	16410¹ NM_008402.1¹ NP_032428.1¹ AK003416⁵ AK036485⁵ (see all 22)

About this table Species with no ortholog for ITGAV

ENSEMBL Gene Tree for ITGAV

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ITGAV gene

ITGA8² ITGA2B² ITGA5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/523 NCBI SNPs in ITGAV are shown (see all 523 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 143)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11902171^1,2	A,C,F,H	187251472(+)	`CGGCTG/CTCAGA`	1	--	ut3¹ ese³		11	EU EA WA NA	970
	rs2230616^1,2	C,F,H	187240662(+)	`ATCATA/GTCTTT`	1	I/V	mis¹ ese³		9	MN EU EA WA	874
	rs6739787^1,2	C,F,H	187161120(+)	`ATTTCC/TTCTCT`	1	--	ng5¹ trp³		8	EU EA WA	834
--	rs13419307^1,2	A,F,H	187161598(+)	`ttatcG/Ataacc`	1	--	ng5¹ tfbs³		4	EU EA WA	420
	rs3738918^1,2	C,F,H	187219711(+)	`TTTATA/GTCTTC`	1	I/V	mis¹ ese³		11	NA EU EA WA	968
	rs7556971^1,2	F,H	187251547(+)	`AGTTCG/ATTAGT`	1	--	ut3¹		4	EU EA WA	410
	rs1839123^1,2	C,F	187251619(-)	`CTACAG/AAGCCA`	1	--	ut3¹ ese³		3	NA	142
	rs11891461^1,2	C,F	187251368(+)	`GGAATA/TAAAAC`	1	--	ut3¹		3	NA	142
--	rs2230615^1,2	F	187229296(+)	`GCAGGT/GCCCCA`	1	A/S	mis¹		8	MN NA EU EA WA	592
	rs1054264^1,2	F	187253730(+)	`CACCCA/CCATTG`	1	--	ut3¹		1	MN	184

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HapMap Linkage Disequilibrium images for ITGAV (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 193210

10/27 Novoseek disease relationships for ITGAV gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adenovirus infections	41.16	3	7533853 (2), 9930328 (1)
metastasis	32.87	19	18427826 (4), 12629984 (2), 16631833 (1), 18794119 (1) (see all 10)
tumors	29.14	22	18357713 (3), 9159820 (2), 12901232 (1), 7538977 (1) (see all 16)
osteosarcoma	22.25	10	18854653 (6), 10429943 (2)
carcinoma lobular	21.70	3	8548120 (2), 7680285 (1)
colon carcinoma	21.61	1	9223381 (1)
cancer	19.99	8	18427826 (2), 18357713 (2), 17786296 (1), 17955485 (1) (see all 5)
melanoma	16.88	7	1285050 (1), 7538977 (1), 1376331 (1), 8641196 (1) (see all 5)
breast carcinoma	14.22	2	8548120 (2)
carcinoma	11.99	5	18427826 (2), 12716042 (1), 9159820 (1)

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Human Genome Epidemiology Navigator: ITGAV (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/387 PubMed articles for ITGAV gene (see all 387 ):

Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. (PubMed id 10965141)^{1, 3, 4} Sims M.A.... Campbell D.A. (2000)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. (PubMed id 15194773)^{3, 4} Williams C.H....Stanway G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{3, 4} Zhang H.... Aebersold R. (2003)
Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. (PubMed id 14596610)^{3, 4} Krokhin O.V....Wilkins J.A. (2003)
Crystal structure of the extracellular segment of integrin alpha Vbeta3. (PubMed id 11546839)^{3, 4} Xiong J.P.... Arnaout M.A. (2001)
The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. (PubMed id 10397733)^{3, 4} Barillari G.... Ensoli B. (1999)
The integrin alpha v gene: identification and characterization of the promoter region. (PubMed id 7522056)^{3, 4} Donahue J.P.... Hawiger J. (1994)
A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. (PubMed id 2467745)^{3, 4} Cheresh D.A.... Quaranta V. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3685	HGNC: 6150	AceView: ITGAV	Ensembl:ENSG00000138448	euGenes: HUgn3685
ECgene: ITGAV	H-InvDB: ITGAV

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ITGAV	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ITGAV
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ITGAV:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ITGAV-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ITGAV		Antibodies for ITGAV
	Explore super-pooled esiRNAs		Proteins for ITGAV
	Lentivirus-delivered shRNAs for ITGAV		Small molecules for ITGAV
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ITGAV)
	Antibodies (ITGAV)
	Chimera RNAi (ITGAV)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ITGAV (integrin alpha5)

	Recombinant Proteins (Integrin alpha V beta 3, Integrin alpha V, Integrin alpha V+beta 5, CD51 + CD61)
	Antibodies (Integrin alpha V beta 3, Integrin alpha V, Integrin alpha V+beta 5, CD51 + CD61)

Search OriGene for ITGAV

Search Tocris compounds for ITGAV

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ITGAV

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ITGAV Gene at Home site.
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ITGAV Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ITGAV

Summaries
for ITGAV

Genomic Location
for ITGAV

Proteins
for ITGAV

Protein Domains/
Families
for ITGAV

Gene Function
for ITGAV

Pathways & Interactions
for ITGAV

Drugs & Compounds
for ITGAV

Transcripts
for ITGAV

Expression
for ITGAV

Orthologs
for ITGAV

Paralogs
for ITGAV

SNPs/Variants
for ITGAV

Disorders & Mutations
for ITGAV

Medical News
for ITGAV

Publications
for ITGAV

Search for ITGAV

Genome Databases showing ITGAV

Other Databases showing ITGAV

Specialized Databases showing ITGAV

Licensable Technologies
for ITGAV

Services
for ITGAV

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ITGAV Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ITGAV

Summariesfor ITGAV

Genomic Locationfor ITGAV

Proteinsfor ITGAV

Protein Domains/Familiesfor ITGAV

Gene Functionfor ITGAV

Pathways & Interactionsfor ITGAV

Drugs & Compoundsfor ITGAV

Transcriptsfor ITGAV

Expression for ITGAV

Orthologsfor ITGAV

Paralogsfor ITGAV

SNPs/Variantsfor ITGAV

Disorders & Mutationsfor ITGAV

Medical Newsfor ITGAV

Publicationsfor ITGAV

Search for ITGAV

Genome Databases showing ITGAV

Other Databases showing ITGAV

Specialized Databases showing ITGAV

Licensable Technologiesfor ITGAV

Servicesfor ITGAV

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ITGAV

Summaries
for ITGAV

Genomic Location
for ITGAV

Proteins
for ITGAV

Protein Domains/
Families
for ITGAV

Gene Function
for ITGAV

Pathways & Interactions
for ITGAV

Drugs & Compounds
for ITGAV

Transcripts
for ITGAV

Expression
for ITGAV

Orthologs
for ITGAV

Paralogs
for ITGAV

SNPs/Variants
for ITGAV

Disorders & Mutations
for ITGAV

Medical News
for ITGAV

Publications
for ITGAV

Licensable Technologies
for ITGAV

Services
for ITGAV