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ITGAV Gene

protein-coding   GIFtS: 71
GCID: GC02P187418

Integrin, Alpha V

(Previous names: antigen identified by monoclonal antibody L230, vitronectin...)
(Previous symbols: VNRA, MSK8, VTNR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha V1 2     Vitronectin Receptor Subunit Alpha2 3
VNRA1 2 3 5     Vitronectin Receptor1
MSK81 2 3     CD512
VTNR1 2     Integrin Alpha-V2
Antigen Identified By Monoclonal Antibody L2301 2     Integrin AlphaVbeta32
Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51)1 2     CD51 Antigen3

External Ids:    HGNC: 61501   Entrez Gene: 36852   Ensembl: ENSG000001384487   OMIM: 1932105   UniProtKB: P067563   

Export aliases for ITGAV gene to outside databases

Previous GC identifers: GC02P185662 GC02P186138 GC02P187657 GC02P187280 GC02P187163 GC02P179314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGAV Gene:
This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral
membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage
to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form
different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta
8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several
extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that
this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple
transcript variants that encode different protein isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for ITGAV Gene:
ITGAV (integrin, alpha V) is a protein-coding gene. Diseases associated with ITGAV include chorioangioma, and cerebral hypoxia. GO annotations related to this gene include protein kinase C binding and virus receptor activity. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756
Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin,
matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the
sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral
Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

Gene Wiki entry for ITGAV Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGAV gene promoter:
         FOXF2   Cart-1   FOXO1a   IRF-7A   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGAV promoter sequence
   Search Chromatin IP Primers for ITGAV

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31-q32   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q31-q32

ITGAV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAV gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P187418:  view genomic region     (about GC identifiers)

Start:
187,454,790 bp from pter      End:
187,545,628 bp from pter
Size:
90,839 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756 (See protein sequence)
Recommended Name: Integrin alpha-V precursor  
Size: 1048 amino acids; 116038 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit.
Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a
receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid
proteins and acts as a receptor for these viruses. Interacts with RAB25. Alpha-V/beta-3 interacts with herpes
virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with CIB1
Sequence caution: Sequence=BAD93131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for ITGAV (see all 7):
1JV2 (3D)        1L5G (3D)        1M1X (3D)        1U8C (3D)        3IJE (3D)        4G1E (3D)    
Secondary accessions: A0AV67 B0LPF4 B7Z883 D3DPG8 E7EWZ6 Q53SK4 Q59EB7 Q6LD15
Alternative splicing: 3 isoforms:  P06756-1   P06756-2   P06756-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGAV: NX_P06756

Explore proteomics data for ITGAV at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys233, Lys360
  • Glycosylation2 at Asn74, Asn290, Asn296, Asn488, Asn554, Asn615, Asn704, Asn835, Asn851, Asn874,
                                 Asn945, Asn973, Asn980
  • Modification sites at PhosphoSitePlus

  • See ITGAV Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138471.1  NP_001138472.1  NP_002201.1  

    ENSEMBL proteins: 
     ENSP00000261023   ENSP00000364042   ENSP00000404291   ENSP00000389442  
    Reactome Protein details: P06756

    ITGAV Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ITGAV Protein
    R&D Systems Recombinant & Natural Proteins for ITGAV (Integrin alpha V beta 8, Integrin alpha V beta 6, Integrin alpha V beta 3, Integrin alpha V beta 5, Integrin alpha V beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ITGAV
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITGAV
    GenScript Custom Purified and Recombinant Proteins Services for ITGAV
    Novus Biologicals ITGAV Proteins
    Novus Biologicals ITGAV Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGAV Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAV
    R&D Systems Antibodies for ITGAV (Integrin alpha V beta 3, Integrin alpha V beta 5, Integrin alpha V/CD51)
    Cell Signaling Technology (CST) Antibodies for ITGAV 
    OriGene Antibodies for ITGAV
    OriGene Custom Antibody Services for ITGAV
    Novus Biologicals ITGAV Antibodies
    Abcam antibodies for ITGAV (P18564, P05106, P18084, P06756)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGAV
    LSBio Antibodies in human, mouse, rat for ITGAV

    ITGAV Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAV
    R&D Systems ELISAs for ITGAV (Integrin alpha V beta 3)         (see all)
    GenScript Custom Assay Services for ITGAV
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P06756

    ProtoNet protein and cluster: P06756

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAV_HUMAN, P06756
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGAV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAV_HUMAN, P06756
    Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin,
    matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the
    sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral
    Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

         Genatlas biochemistry entry for ITGAV:
    integrin,alpha V,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand
    factor,thrombospondin,fibronectin,osteopontin,collagen receptors;with ITGB1 or ITGB5 in vitronectin receptor;with
    ITGB6 in fibronectin receptor

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0001846contributes to opsonin binding ISS--
    GO:0005080contributes to protein kinase C binding ISS--
    GO:0005245voltage-gated calcium channel activity IDA18395422
    GO:0005515protein binding IPI11546839
         
    ITGAV for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for ITGAV:
     Decreased focal adhesion (FA)   Decreased viability of wild-ty  Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin 
     Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itgav) (see all 16):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  renal/urinary system 

    ITGAV for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGAV: Itgavtm1Hyn Itgavtm2.1Hyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGAV
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGAV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAV
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAV

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGAV:
    hsa-mir-32-5p (MIRT028372), hsa-mir-192-5p (MIRT026587), hsa-mir-215-5p (MIRT024872), hsa-mir-142-3p (MIRT021641), hsa-mir-196a-5p (MIRT026088)

    Block miRNA regulation of human, mouse, rat ITGAV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGAV (see all 41):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-146a hsa-miR-25 hsa-let-7a-2* hsa-miR-4325 hsa-miR-520g hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidITGAV 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGAV
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAV

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAV (see all 18)
    OriGene ORF clones in mouse, rat for ITGAV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITGAV (NM_002210)
    Sino Biological Human cDNA Clone for ITGAV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAV

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAV
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAV 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAV


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITAV_HUMAN, P06756: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS11877390
    GO:0008305integrin complex NAS11877390
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ISS--

    ITGAV for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGAV About   (see all 54)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGAV
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGAV (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for ITGAV
        Angiogenesis
    Adhesion

    2 Tocris Bioscience Pathways for ITGAV
        NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for ITGAV (see all 6)
        Development VEGF-family signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Development VEGF signaling via VEGFR2 - generic cascades
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin inside-out signaling

    Selected BioSystems Pathways for ITGAV (see all 12)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    S1P1 pathway
    Signaling events mediated by VEGFR1 and VEGFR2


    Selected Reactome Pathways for ITGAV (see all 9)
        Cross-presentation of particulate exogenous antigens (phagosomes)
    Laminin interactions
    Integrin cell surface interactions
    Elastic fibre formation
    PECAM1 interactions

    1 PharmGKB Pathway for ITGAV
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for ITGAV) (see all 13):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)


    ITGAV for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAV (see all 10): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGAV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGAV (P067561, 2, 3 ENSP000002610234) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051061, 2, 3EBI-298282,EBI-702847 MINT-8216018 MINT-8216025 MINT-25081 I2D: score=5 
    ITGB5P180841, 3, ENSP000002961814EBI-298282,EBI-1223434 I2D: score=4 STRING: ENSP00000296181
    ITGB1P055563, ENSP000003640944I2D: score=3 STRING: ENSP00000364094
    ITGB6P185643, ENSP000002832494I2D: score=3 STRING: ENSP00000283249
    ANGPTL3Q9Y5C13, ENSP000003601704I2D: score=2 STRING: ENSP00000360170
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP11866539
    GO:0001568blood vessel development ----
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0007155cell adhesion IDA10218736

    ITGAV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGAV (ITAV)

    1 DrugBank Compound for ITGAV    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600

    8 Novoseek inferred chemical compound relationships for ITGAV gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    penton 82.3 9 9930328 (2), 9135136 (1), 7533853 (1), 8837891 (1) (see all 7)
    lm 609 67.8 2 12901232 (1), 12379637 (1)
    fibrinogen 31.4 2 9033403 (2)
    vegf 30.8 15 18854653 (5), 16496302 (2), 19212638 (2), 16598467 (1) (see all 6)
    calcium 3.66 1 17158881 (1)
    titanium 1.36 1 10817264 (1)
    tyrosine 0 2 17228150 (1)
    hydroxyapatite 0 2 10817264 (1), 18780564 (1)



    ITGAV for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITGAV gene (3 alternative transcripts): 
    NM_001144999.2  NM_001145000.2  NM_002210.4  

    Unigene Cluster for ITGAV:

    Integrin, alpha V
    Hs.436873  [show with all ESTs]
    Unigene Representative Sequence: NM_002210
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261023(uc002upq.3 uc010frs.3 uc010zfv.2) ENST00000374907
    ENST00000433736 ENST00000460641 ENST00000496477 ENST00000496854 ENST00000474571
    ENST00000430709
    miRNA
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    Block miRNA regulation of human, mouse, rat ITGAV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGAV (see all 41):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-146a hsa-miR-25 hsa-let-7a-2* hsa-miR-4325 hsa-miR-520g hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidITGAV 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITGAV
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAV
    Clone
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    OriGene clones in human, mouse for ITGAV (see all 18)
    OriGene ORF clones in mouse, rat for ITGAV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ITGAV (NM_002210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAV
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAV
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAV
      QuantiTect SYBR Green Assays in human, mouse, rat ITGAV
      QuantiFast Probe-based Assays in human, mouse, rat ITGAV

    Additional mRNA sequence: 

    AB209894.1 AK302550.1 AK302990.1 AK309711.1 BC047454.1 BC072686.1 BC126231.1 BC136442.1 
    BC144100.1 EF560727.1 M14648.1 

    11 DOTS entries:

    DT.99956906  DT.91755266  DT.100795812  DT.91755262  DT.100795820  DT.75107177  DT.120970004  DT.91850420 
    DT.95191020  DT.120969933  DT.120969966 

    Selected AceView cDNA sequences (see all 305):

    AA587812 BG260819 AU132646 AW772513 CA396552 BQ002676 BX481015 AI702361 
    AU137550 AA030046 AI636254 AA214606 BU682417 AA307350 BM311731 CA389708 
    AI274861 BM984332 BC072686 AI351881 AW341935 NM_002210 AI362557 CB140017 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAV    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                -     -                                                                                                                     

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for ITGAV

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGAV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTTGTGA
    ITGAV Expression
    About this image


    ITGAV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Kidney (Urinary System)
             Epithelial Podocyte-like cells
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Inner Enamel Epithelial Cells Dental Enamel
    ITGAV Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGAV Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436873
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAV (see all 10): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ITGAV gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgav1 , 5 integrin alpha V1, 5 87.87(n)1
    93.69(a)1
      2 (49.33 cM)5
    164101  NM_008402.31  NP_032428.21 
     837243975 
    chicken
    (Gallus gallus)
    Aves ITGAV1 integrin, alpha V 78.43(n)
    83.48(a)
      396420  NM_205439.1  NP_990770.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGAV6
    integrin, alpha V
    79(a)
    1 ↔ 1
    GL343737.1(30207-112534)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979972 integrin alphaV subunit 76.25(n)    U92006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itgav1 integrin, alpha V 62.62(n)
    61.26(a)
      100151255  NM_001033721.1  NP_001028893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta if3 maintenance of protein localization
    cell adhesion more
    31(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F54F2.13 Vitronectin receptor alpha subunit 30(a)
    (best of 2)
      III(8890624-8896700)   --


    ENSEMBL Gene Tree for ITGAV (if available)
    TreeFam Gene Tree for ITGAV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGAV gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGAV using alignment to 5 protein entries:     ITAV_HUMAN (see all proteins):
    ITGA8    ITGA5    ITGA2B    ITGA4

    ITGAV for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGAV (see all 2194)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349862921,2
    C--186851184(+) AGCATT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1902698911,2
    --186851310(+) CTCCCA/GAGTAG 1 -- us2k10--------
    rs617636181,2
    C--186851391(+) TGTTGG/ATCTCA 1 -- us2k12Minor allele frequency- A:0.01NS 78
    rs1828127431,2
    --186851443(+) AGTGTG/TGGGAT 1 -- us2k10--------
    rs1867759131,2
    --186851617(+) ATAGGA/GCGTGG 1 -- us2k10--------
    rs1493855231,2
    --186851679(+) TGTCAC/GAAAGC 1 -- us2k10--------
    rs1446652371,2
    --186851862(+) TGTTTC/GCTTTG 1 -- us2k10--------
    rs617636191,2
    C,F--186851885(+) AAGTGA/GCTTAG 1 -- us2k12Minor allele frequency- G:0.01NS 94
    rs1915717971,2
    --186851944(+) TTGTCC/TGCCTG 1 -- us2k10--------
    rs617636201,2
    C,F--186851984(+) ATCAGT/GTTCTT 1 -- us2k12Minor allele frequency- G:0.01NS 94

    HapMap Linkage Disequilibrium report for ITGAV (187454790 - 187545628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ITGAV:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721241CNV Deletion23290073
    esv1634124CNV Insertion17803354
    nsv875552CNV Loss21882294
    nsv818105CNV Gain17921354
    dgv1279e1CNV Complex17122850
    dgv1280e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAV
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 193210    OMIM disorders: --

    Selected diseases for ITGAV (see all 84):    
    About MalaCards
    chorioangioma    cerebral hypoxia    localized scleroderma    priapism
    mouth disease    arteriovenous malformation    bronchiectasis    cutaneous malignant melanoma
    scleroderma    cavernous malformation    hypoxia    laryngeal squamous cell carcinoma
    kaposi's sarcoma    rheumatic disease    sickle cell disease    chondrosarcoma
    cytomegalovirus infection    endometrial adenocarcinoma    squamous cell carcinoma    squamous cell carcinoma of the head and neck


    ITGAV for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ITGAV gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenovirus infections 40.3 3 7533853 (2), 9930328 (1)
    metastasis 32.8 20 18427826 (4), 12629984 (2), 16631833 (1), 18794119 (1) (see all 11)
    tumors 29.4 23 18357713 (3), 9159820 (2), 12901232 (1), 7538977 (1) (see all 17)
    lung carcinoma 22.4 2 9354507 (1), 16569454 (1)
    osteosarcoma 21.2 10 18854653 (6), 10429943 (2)
    carcinoma lobular 21.1 3 8548120 (2), 7680285 (1)
    colon carcinoma 20.8 1 9223381 (1)
    cancer 19.5 8 18427826 (2), 18357713 (2), 17786296 (1), 17955485 (1) (see all 5)
    melanoma 15.8 7 1285050 (1), 7538977 (1), 1376331 (1), 8641196 (1) (see all 5)
    breast carcinoma 13.4 2 8548120 (2)

    Genetic Association Database (GAD): ITGAV
    Human Genome Epidemiology (HuGE) Navigator: ITGAV (14 documents)

    Export disorders for ITGAV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGAV gene, integrated from 10 sources (see all 583):
    (articles sorted by number of sources associating them with ITGAV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. (PubMed id 10965141)1, 2, 9 Sims M.A.... Campbell D.A. (Cytogenet. Cell Genet. 2000)
    2. The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study. (PubMed id 17615072)1, 4, 9 Jacq L....CornAclis F. (amp 2007)
    3. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)1, 4, 9 Brendle A....FAPrsti A. (Carcinogenesis 2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Integrin alpha V polymorphisms and haplotypes in a Korean population are associated with susceptibility to chronic hepatitis and hepatocellular carcinoma. (PubMed id 18694400)1, 4 Lee S.K....Kwack K. (Liver Int. 2009)
    8. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. (PubMed id 19590686)1, 4 Wilker E....Schwartz J. (Environ. Health Perspect. 2009)
    9. The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. (PubMed id 19818132)1, 4 Hollis-Moffatt J.E....Merriman T.R. (amp 2009)
    10. Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. (PubMed id 18045938)1, 2 Garrigues H.J....Rose T.M. (J. Virol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3685 HGNC: 6150 AceView: ITGAV Ensembl:ENSG00000138448 euGenes: HUgn3685
    ECgene: ITGAV Kegg: 3685 H-InvDB: ITGAV

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGAV Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAV Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ITGAV gene:
    Search GeneIP for patents involving ITGAV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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