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Aliases for ITGAM Gene

Aliases for ITGAM Gene

  • Integrin Subunit Alpha M 2 3 5
  • Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit) 2 3
  • Cell Surface Glycoprotein MAC-1 Subunit Alpha 3 4
  • Complement Component 3 Receptor 3 Subunit 2 3
  • CD11 Antigen-Like Family Member B 3 4
  • Leukocyte Adhesion Receptor MO1 3 4
  • CR-3 Alpha Chain 3 4
  • CD11B 3 4
  • CR3A 3 4
  • Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide) 2
  • Neutrophil Adherence Receptor Alpha-M Subunit 3
  • Macrophage Antigen Alpha Polypeptide 3
  • Neutrophil Adherence Receptor 4
  • Antigen CD11b (P170) 3
  • Integrin Alpha-M 3
  • CD11b Antigen 4
  • MAC-1 3
  • MAC1A 3
  • SLEB6 3
  • MO1A 3

External Ids for ITGAM Gene

Previous HGNC Symbols for ITGAM Gene

  • CR3A
  • CD11B

Previous GeneCards Identifiers for ITGAM Gene

  • GC16P030449
  • GC16P031767
  • GC16P031268
  • GC16P031307
  • GC16P031168
  • GC16P028833

Summaries for ITGAM Gene

Entrez Gene Summary for ITGAM Gene

  • This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for ITGAM Gene

ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematous, Association With 6 and Itgam-Related Susceptibility To Systemic Lupus Erythematosus. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Immune response_Role of integrins in NK cells cytotoxicity. GO annotations related to this gene include protein heterodimerization activity and glycoprotein binding. An important paralog of this gene is ITGAX.

UniProtKB/Swiss-Prot for ITGAM Gene

  • Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Gene Wiki entry for ITGAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAM Gene

Genomics for ITGAM Gene

Regulatory Elements for ITGAM Gene

Enhancers for ITGAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F031125 1.3 FANTOM5 Ensembl ENCODE 18.5 -128.8 -128829 10.7 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KAT8 ITGAX ZNF764 BCL7C ITGAM ZNF646 ZNF668 ENSG00000260267 ENSG00000260304 NPIPB13
GH16F031350 1 FANTOM5 ENCODE 8.4 +90.6 90620 0.9 BCOR ZNF146 ZMYM3 MAX EGR2 ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 HSD3B7 ZNF668 FUS
GH16F031116 1.3 FANTOM5 ENCODE 8.3 -141.6 -141555 3.9 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KAT8 ITGAX ENSG00000260304 ENSG00000260267 STX4 NDUFA3P6 ENSG00000261648 VN1R64P ENSG00000261475 VN1R65P
GH16F031252 1.5 FANTOM5 Ensembl ENCODE 7.7 -6.1 -6067 2.6 ATF1 PKNOX1 ARNT ZNF493 FOS ZNF202 JUNB NCOA1 REST ZNF623 ENSG00000260267 ZNF720 ZNF747 ZNF764 ENSG00000260304 NPIPB13 PYDC1 BCL7C ZNF785 ENSG00000261474
GH16F031351 1.4 FANTOM5 ENCODE 6.5 +92.4 92407 2.0 HDGF TBL1XR1 MTA2 ZMYM3 CEBPB EBF1 EP300 RELA TARDBP EED ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 HSD3B7 LOC647086 TRIM72
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ITGAM on UCSC Golden Path with GeneCards custom track

Promoters for ITGAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000506576 433 1201 ZFHX2 PBX2 IKZF1 PRDM10 SPI1 EGR2

Genomic Location for ITGAM Gene

Chromosome:
16
Start:
31,259,967 bp from pter
End:
31,332,892 bp from pter
Size:
72,926 bases
Orientation:
Plus strand

Genomic View for ITGAM Gene

Genes around ITGAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAM Gene

Proteins for ITGAM Gene

  • Protein details for ITGAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11215-ITAM_HUMAN
    Recommended name:
    Integrin alpha-M
    Protein Accession:
    P11215
    Secondary Accessions:
    • Q4VAK0
    • Q4VAK1
    • Q4VAK2

    Protein attributes for ITGAM Gene

    Size:
    1152 amino acids
    Molecular mass:
    127179 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3 (PubMed:15194813, PubMed:12208882). Interacts with THBD (PubMed:27055590).

    Three dimensional structures from OCA and Proteopedia for ITGAM Gene

    Alternative splice isoforms for ITGAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGAM Gene

Post-translational modifications for ITGAM Gene

  • Glycosylation at Asn 86, Asn 240, Asn 391, Asn 469, Asn 692, Asn 696, Asn 734, Asn 801, Asn 880, Asn 900, Asn 911, Asn 940, Asn 946, Asn 978, Asn 993, Asn 1021, Asn 1044, Asn 1050, and Asn 1075
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGAM Gene

Domains & Families for ITGAM Gene

Suggested Antigen Peptide Sequences for ITGAM Gene

Graphical View of Domain Structure for InterPro Entry

P11215

UniProtKB/Swiss-Prot:

ITAM_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAM: view

Function for ITGAM Gene

Molecular function for ITGAM Gene

GENATLAS Biochemistry:
integrin,alpha M,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in vitronectin,fibrinogen,von Willebrand factor,thrombospondin,fibronectin,osteopontin,collagen
UniProtKB/Swiss-Prot Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Gene Ontology (GO) - Molecular Function for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 15004192
GO:0005515 protein binding IPI 15194813
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ITGAM: view
genes like me logo Genes that share phenotypes with ITGAM: view

Human Phenotype Ontology for ITGAM Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGAM Gene

MGI Knock Outs for ITGAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGAM

miRNA for ITGAM Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAM
  • R&D Systems cDNA Clones for ITGAM (CD11b/Integrin alpha M)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGAM Gene

Localization for ITGAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAM Gene COMPARTMENTS Subcellular localization image for ITGAM gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
lysosome 2
mitochondrion 2
nucleus 2
vacuole 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009986 cell surface IDA 19234460
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ITGAM: view

Pathways & Interactions for ITGAM Gene

genes like me logo Genes that share pathways with ITGAM: view

Gene Ontology (GO) - Biological Process for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0010668 ectodermal cell differentiation IEP 23154389
GO:0030198 extracellular matrix organization TAS --
GO:0034142 toll-like receptor 4 signaling pathway TAS --
genes like me logo Genes that share ontologies with ITGAM: view

No data available for SIGNOR curated interactions for ITGAM Gene

Drugs & Compounds for ITGAM Gene

(57) Drugs for ITGAM Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Leukadherin 1 Pharma CD11b/CD18 activator 0

(60) Additional Compounds for ITGAM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ITGAM Gene

Compound Action Cas Number
Leukadherin 1 CD11b/CD18 activator 344897-95-6
genes like me logo Genes that share compounds with ITGAM: view

Transcripts for ITGAM Gene

Unigene Clusters for ITGAM Gene

Integrin, alpha M (complement component 3 receptor 3 subunit):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAM
  • R&D Systems cDNA Clones for ITGAM (CD11b/Integrin alpha M)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAM Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1:
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1: -
SP2: -
SP3:

Relevant External Links for ITGAM Gene

GeneLoc Exon Structure for
ITGAM
ECgene alternative splicing isoforms for
ITGAM

Expression for ITGAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGAM Gene

This gene is overexpressed in Whole Blood (x31.3).

Protein differential expression in normal tissues from HIPED for ITGAM Gene

This gene is overexpressed in Neutrophil (31.4), Nasal epithelium (9.4), and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAM Gene



Protein tissue co-expression partners for ITGAM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAM Gene:

ITGAM

SOURCE GeneReport for Unigene cluster for ITGAM Gene:

Hs.172631

mRNA Expression by UniProt/SwissProt for ITGAM Gene:

P11215-ITAM_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes.
genes like me logo Genes that share expression patterns with ITGAM: view

Primer Products

Orthologs for ITGAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAM 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ITGAM 34 35
  • 81.68 (n)
cow
(Bos Taurus)
Mammalia ITGAM 34 35
  • 81.34 (n)
mouse
(Mus musculus)
Mammalia Itgam 34 16 35
  • 78.61 (n)
rat
(Rattus norvegicus)
Mammalia Itgam 34
  • 77.99 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia itgad 34
  • 52.48 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882585 34
  • 47.15 (n)
si:dkey-32n7.4 35
  • 36 (a)
ManyToMany
Species where no ortholog for ITGAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAM Gene

ENSEMBL:
Gene Tree for ITGAM (if available)
TreeFam:
Gene Tree for ITGAM (if available)

Paralogs for ITGAM Gene

(4) SIMAP similar genes for ITGAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITGAM: view

Variants for ITGAM Gene

Sequence variations from dbSNP and Humsavar for ITGAM Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs41321249 Benign 31,330,103(+) CCACA(A/C)CAAGG nc-transcript-variant, reference, missense
rs10574650 -- 31,330,796(+) AACAG(-/AC)ACAGA intron-variant
rs10647928 -- 31,277,359(+) GCTAA(-/T/TT)TTTTT intron-variant
rs10661829 -- 31,330,807(+) GACAG(-/AC)ACAAA intron-variant
rs10661830 -- 31,330,874(+) GAGAT(-/AGAG)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAM Gene

Variant ID Type Subtype PubMed ID
dgv503e214 CNV gain 21293372
esv1039007 CNV deletion 17803354
esv2052288 CNV deletion 18987734
esv2436135 CNV deletion 19546169
esv2714193 CNV deletion 23290073
esv3553318 CNV deletion 23714750
esv3553319 CNV deletion 23714750
nsv1061980 CNV gain 25217958
nsv1071284 CNV deletion 25765185
nsv1111132 CNV tandem duplication 24896259
nsv1138424 CNV deletion 24896259
nsv953803 CNV deletion 24416366
nsv958208 CNV deletion 24416366

Variation tolerance for ITGAM Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAM Gene

Human Gene Mutation Database (HGMD)
ITGAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAM Gene

Disorders for ITGAM Gene

MalaCards: The human disease database

(24) MalaCards diseases for ITGAM Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematous, association with 6
  • systemic lupus erythematosus 6
itgam-related susceptibility to systemic lupus erythematosus
  • sleb6
granulocytopenia
  • agranulocytosis
shwartzman phenomenon
  • shwartzman reaction
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency, type iii
- elite association - COSMIC cancer census association via MalaCards
Search ITGAM in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ITAM_HUMAN
  • Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18204446, ECO:0000269 PubMed:18204448}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for ITGAM

Genetic Association Database (GAD)
ITGAM
Human Genome Epidemiology (HuGE) Navigator
ITGAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAM
genes like me logo Genes that share disorders with ITGAM: view

No data available for Genatlas for ITGAM Gene

Publications for ITGAM Gene

  1. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PMID: 18204446) Harley J.B. … Kelly J.A. (Nat. Genet. 2008) 3 4 46 64
  2. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. (PMID: 18204448) Nath S.K. … Harley J.B. (Nat. Genet. 2008) 3 4 46 64
  3. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. (PMID: 1683702) Shelley C.S. … Arnaout M.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 22 64
  4. ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population. (PMID: 20666624) WarchoA8 T. … JagodziA8ski P.P. (DNA Cell Biol. 2011) 3 46 64
  5. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. (PMID: 20881011) Webb R. … Sawalha A.H. (Ann. Rheum. Dis. 2011) 3 46 64

Products for ITGAM Gene

Sources for ITGAM Gene

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