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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGAM Gene

protein-coding GIFtS: 68
GCID: GC16P031271

integrin, alpha M (complement component 3 receptor 3 subunit)

(Previous names: integrin, alpha M (complement component receptor 3, alpha;...)
(Previous symbols: CR3A, CD11B)

Explore 114 diseases affiliated with
ITGAM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)¹ ²		CD11b¹
CD11B¹ ² ³ ⁵		Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide)¹
CR3A¹ ² ³ ⁵		MO1A²
MAC-1¹ ²		Antigen CD11b (P170)²
Cell Surface Glycoprotein MAC-1 Subunit Alpha² ³		Integrin Alpha-M²
Leukocyte Adhesion Receptor MO1² ³		Macrophage Antigen Alpha Polypeptide²
CD11 Antigen-Like Family Member B² ³		Neutrophil Adherence Receptor Alpha-M Subunit²
CR-3 Alpha Chain² ³		CD11b Antigen³
MAC1A² ⁵		Neutrophil Adherence Receptor³
SLEB6² ⁵

External Ids:	HGNC: 6149¹	Entrez Gene: 3684²	Ensembl: ENSG00000169896⁷	OMIM: 120980⁵	UniProtKB: P11215³

Export aliases for ITGAM gene to outside databases

Previous GC identifers: GC16P030449 GC16P031767 GC16P031268 GC16P031307 GC16P031168 GC16P028833

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAM:

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an

alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a

leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3

('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated

endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215

Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and

granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the

receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b.

Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of

fibrinogen gamma chain

Gene Wiki entry for ITGAM (Integrin alpha M)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGAM gene promoter:
C/EBPbeta Sp1 AP-1 ATF-2 Lmo2 c-Jun Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGAM promoter sequence

Search SABiosciences Chromatin IP Primers for ITGAM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

ITGAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAM gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P031271: view genomic region (about GC identifiers)

Start:	31,271,288 bp from pter	End:	31,344,213 bp from pter
Size:	72,926 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215 (See protein sequence)

Recommended Name: Integrin alpha-M precursor

Size: 1152 amino acids; 127179 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3

Subcellular location: Membrane; Single-pass type I membrane protein

6/14 PDB 3D structures from and Proteopedia for ITGAM (see all 14):

1A8X (3D)

1BHO (3D)

1BHQ (3D)

1IDN (3D)

1IDO (3D)

1JLM (3D)

Secondary accessions: Q4VAK0 Q4VAK2

Explore the universe of human proteins at neXtProt for ITGAM: NX_P11215

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11215

ITGAM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000623.2 NP_001139280.1

ENSEMBL proteins:

ENSP00000287497 ENSP00000441691 ENSP00000454568 ENSP00000461850

Reactome Protein details: P11215
Human Recombinant Protein Products:

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	Novus Biologicals ITGAM Proteins
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	ProSpec Recombinant Protein for ITGAM
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	--	--

ITGAM for ontologies About GeneDecksing

ITGAM Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAM
	R&D Systems Antibodies for ITGAM (Integrin alpha M/CD11b)
	OriGene Antibodies (see all 3): ITGAM OriGene Custom Antibody Services for ITGAM
	GenScript Custom Superior Antibodies Services for ITGAM
	Novus Biologicals ITGAM Antibodies
	Abcam antibodies for ITGAM
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ITGAM

Assay Products for ITGAM:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for ITGAM (Integrin alpha M/CD11b)
	GenScript Custom Assay Services for ITGAM
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGAM for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P11215

ProtoNet protein and cluster: P11215

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215

Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and

granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the

receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b.

Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of

fibrinogen gamma chain

Genatlas biochemistry entry for ITGAM:

integrin,alpha M,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,dimerizing with ITGB2 in vitronectin,fibrinogen,von Willebrand

factor,thrombospondin,fibronectin,osteopontin,collagen

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ITGAM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAM
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAM:
		hsa-miR-661 hsa-miR-3941 hsa-miR-412
		SwitchGear 3'UTR luciferase reporter plasmid: ITGAM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAM (see all 7) OriGene shRNA RFP: ITGAM OriGene siRNA: ITGAM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAM

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGAM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAM (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAM (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ITGAM (NM_000632)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGAM
		Search LifeMap BioReagents cell lines for ITGAM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAM

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001846	opsonin binding	IEA	--
GO:0001948	glycoprotein binding	IPI	15004192
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	15194813
GO:0008201	heparin binding	IEA	--

ITGAM for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ITGAM: Itgam^tm1Rws Itgam^tm1Myd Itgam^tm1Bll
     5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Itgam):

cellular

hematopoietic system

homeostasis/metabolism

immune system

nervous system

ITGAM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Immune response_Alternative complement pathway

	Immune response Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response_Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for ITGAM

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response Lectin Induced complement pathway

5/36 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAM (see all 36)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

4 GeneGo (Thomson Reuters) Pathways for ITGAM

	Immune response Alternative complement pathway
	Immune response Classical complement pathway
	Immune response Role of integrins in NK cells cytotoxicity
	Immune response Lectin induced complement pathway

4 BioSystems Pathways for ITGAM

	Integrin-mediated cell adhesion
	Focal Adhesion
	IL-5 Signaling Pathway
	amb2 Integrin signaling

5/8 Reactome Pathways for ITGAM (see all 8)

	Hemostasis
	Integrin cell surface interactions
	Toll Like Receptor 4 (TLR4) Cascade
	Toll-Like Receptors Cascades
	Signal Transduction

5/10 Kegg Pathways (Kegg details for ITGAM) (see all 10):

	Phagosome
	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

ITGAM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGAM

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/90 Interacting proteins for ITGAM (P11215^{2, 3} ENSP00000287497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLEC4M	Q9H2X3²^,³, ENSP00000316228⁴	MINT-72825 MINT-72823 I2D: score=1 STRING: ENSP00000316228
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=5 STRING: ENSP00000303242
ICAM1	P05362³, ENSP00000264832⁴	I2D: score=3 STRING: ENSP00000264832
IRAK1	P51617³, ENSP00000358997⁴	I2D: score=3 STRING: ENSP00000358997
JAM3	Q9BX67³, ENSP00000299106⁴	I2D: score=2 STRING: ENSP00000299106

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2563162
GO:0007159	leukocyte cell-cell adhesion	IEA	--
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0014005	microglia development	IEA	--

ITGAM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGAM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGAM
10/116 Novoseek chemical compound relationships for ITGAM gene (see all 116) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp	81.8	92	1672890 (5), 20348036 (4), 16249234 (4), 8100744 (3) (see all 53)
n-formylmethionyl-leucylphenylalanine	75.2	22	10500036 (2), 7508644 (1), 1680065 (1), 15673886 (1) (see all 18)
cuprophan	66.3	15	9890318 (3), 8079969 (3), 8770974 (2), 1292337 (1) (see all 8)
nitroblue tetrazolium	65.6	18	8947589 (2), 12618899 (1), 2359342 (1), 8260698 (1) (see all 10)
5-oxoete	64.6	6	9300719 (3), 11174193 (1), 19164129 (1), 18292294 (1)
kh 1060	58.3	3	9823949 (2)
bwa868c	56.5	1	11535533 (1)
retinoic acid	54.2	30	17561254 (3), 9067636 (2), 9823949 (2), 17917245 (2) (see all 18)
leukotriene b4	52.4	15	14722206 (3), 19048279 (2), 8926047 (2), 12952263 (1) (see all 7)
fibrinogen	52.3	51	16241954 (4), 12469900 (2), 19281927 (2), 10353467 (2) (see all 31)

Search CenterWatch for drugs/clinical trials and news about ITGAM / ITAM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGAM gene (2 alternative transcripts):

NM_000632.3 NM_001145808.1

Unigene Cluster for ITGAM:

Integrin, alpha M (complement component 3 receptor 3 subunit)

Hs.172631 [show with all ESTs]

Unigene Representative Sequence: NM_001145808

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000287497(uc010cam.1 uc002ebs.1) ENST00000544665(uc002ebq.3 uc002ebr.3 uc010can.3)

ENST00000570242 ENST00000567031 ENST00000561838 ENST00000567178 ENST00000569746

ENST00000565142

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAM
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAM:
		hsa-miR-661 hsa-miR-3941 hsa-miR-412
		SwitchGear 3'UTR luciferase reporter plasmid: ITGAM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAM (see all 7) OriGene shRNA RFP: ITGAM OriGene siRNA: ITGAM
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAM (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAM (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAM

Additional cDNA sequence:

AK057856.1 AK127637.1 AY187247.1 AY187248.1 BC096346.3 BC096347.3 BC096348.3 BC099660.3

J03925.1 J04145.1 M18044.1

8 DOTS entries:

DT.410499 DT.87016127 DT.95144732 DT.91711441 DT.92422257 DT.91883151 DT.95295494 DT.95342181

24/93 AceView cDNA sequences (see all 93):

BU684507 BF901924 BF933045 M18044 BI022050 AY187248 BI031616 AY187247

BP366620 AK057856 BG057336 CA307360 BP362919 AK127637 BF897564 BV185720

BP345653 BE243071 AA436187 J03925 BV185721 BV185719 BV185717 BX644572

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAM About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:
SP2:															-		-		-		-		-		-		-		-		-		-				-
SP3:									-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	22a	·	22b	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30
SP1:			-
SP2:			-
SP3:

ECgene alternative splicing isoforms for ITGAM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGAM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGCCGTG

About this image

ITGAM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

Granulocyte-Monocyte Progenitor Cells

Selective marker (cell-identifying gene)

Blood

Blood

Blood

Myeloid Dendritic Cells

Blood

Blood

Extraembryonic Tissues, Placenta

Adipose

Vascular Adipose

Stromal Vascular Preadipocyte Progenitor Cells

Adipose

Bone

Bone Marrow

Hematopoietic Stem Cells

Blood

Umbilical Cord

Wharton's Jelly

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Mesenchymal stem cell (Adult Stem / Progenitor Cell)

Bone

Monocyte-like cells (Derivation of dendri...)

See ITGAM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGAM

SOURCE GeneReport for Unigene cluster: Hs.172631

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215

Tissue specificity: Predominantly expressed in monocytes and granulocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGAM (see all 9):

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Terminal Differentiation Markers in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Innate & Adaptive Immune Responses in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGAM gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	47(a) 43(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343220.1(2391221-2422669) GL343220.1(2431120-2468441)
zebrafish (Danio rerio)	Actinopterygii	LOC563715¹	integrin alpha-M-like	48.7(n) 40.4(a)		563715 XM_687072.4 XP_692164.4
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ alphaPS4⁶ (see all 3)	alphaPS4 (see all 3)	18(a) 17(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11146272-11150371)

ENSEMBL Gene Tree for ITGAM (if available)
TreeFam Gene Tree for ITGAM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGAM gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGA11² ITGA2² ITGA5²

ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9² ITGA4²

ITGA10²

4 SIMAP similar genes for ITGAM using alignment to 4 protein entries: ITAM_HUMAN (see all proteins):

ITGAD ITGAX FLJ00114 ITGAL

ITGAM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114758195^1,2	F,	--	31269479(+)	`AAAAGT/GGACAG`	2	--	us2k¹		1		WA	118
rs150828639^1,2		--	31269496(+)	`GGGAGA/GGTAAG`	2	--	us2k¹		0	--	--	--	--
rs187303659^1,2		--	31269532(+)	`TGAACA/CATTCC`	2	--	us2k¹		0	--	--	--	--
rs8057320^1,2	C,F,A,H,	--	31269551(+)	`ATATTT/CAGGTT`	2	--	us2k¹ tfbs³		21		NS EA NA WA CSA	2334
rs192245345^1,2		--	31269598(+)	`AACAAA/GCTTGC`	2	--	us2k¹		0	--	--	--	--
rs184674471^1,2		--	31269764(+)	`AGGTGA/CCTGCC`	2	--	us2k¹		0	--	--	--	--
rs41364046^1,2	C,	--	31269867(+)	`ACCCCA/GCCTCA`	2	--	us2k¹		0	--	--	--	--
rs8058867^1,2	C,	--	31270039(+)	`ACACAC/AAAATA`	2	--	us2k¹		4		WA CSA NA EA	243
rs192508595^1,2		--	31270071(+)	`CCTGTA/TATCTC`	2	--	us2k¹		0	--	--	--	--
rs12935156^1,2	C,F,	--	31270172(+)	`aaattT/Aaaaaa`	2	--	us2k¹		5		NA WA	244

HapMap Linkage Disequilibrium report for ITGAM (31271288 - 31344213 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ITGAM
1 CNV: 102246
2 Indels: 25635 45419
Human Gene Mutation Database (HGMD): ITGAM

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGAM for disorders           About GeneDecksing

OMIM gene information: 120980
OMIM disorders: 609939
UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215

Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6

(SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic

disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought

to represent a failure of the regulatory mechanisms of the autoimmune system

20/114 diseases for ITGAM (see all 114): About MalaCards

hypersensitivity reaction type ii disease lichen planus age related macular degeneration central nervous system disease

oral lichen planus pre-eclampsia myocardial infarction nervous system disease

bronchopulmonary dysplasia familial mediterranean fever acute myocardial infarction systemic lupus erythematosus

glycogen storage disease lupus erythematosus type 1 diabetes mellitus hemorrhagic fever

coronary heart disease polycythemia vera systemic lupus erythematosus, association with dermatitis herpetiformis

8 diseases from the University of Copenhagen DISEASES database for ITGAM:

Leukemia Vascular disease Leukocyte adhesion deficiency Leukopenia

Asthma Arthritis Hypersensitivity reaction type II disease Respiratory failure

10/73 Novoseek disease relationships for ITGAM gene (see all 73) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	58.5	44	15104334 (5), 11920354 (4), 10029565 (3), 15217824 (1) (see all 28)
shwartzman reaction	48.3	1	18424751 (1)
necrosis	48.3	34	11408721 (2), 8394087 (1), 12431190 (1), 7517990 (1) (see all 30)
leukemia	45.9	5	10978780 (1), 17561254 (1), 7579392 (1), 18173208 (1) (see all 5)
myeloid leukemia	45	2	11893077 (2)
promyelocytic leukemia	44.2	1	19415458 (1)
sepsis	38.3	18	8554683 (2), 16670636 (2), 11433091 (2), 9529172 (1) (see all 13)
agranulocytosis	32.3	4	8856254 (2), 1292337 (1), 7490516 (1)
systemic inflammatory response syndrome	27.5	1	10545303 (1)
monocytic leukemia	25.6	1	20438701 (1)

Genetic Association Database (GAD): ITGAM
Human Genome Epidemiology (HuGE) Navigator: ITGAM (28 documents)

Export disorders for ITGAM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGAM gene, integrated from 9 sources (see all 977):
(articles sorted by number of sources associating them with ITGAM)

Utopia: connect your pdf to the dynamic
world of online information

The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. (PubMed id 1683702)^{1, 2, 9} Shelley C.S. and Arnaout M.A. (1991)
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)^{1, 4, 9} Hellmig S....Schreiber S. (2005)
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PubMed id 18204446)^{1, 2} Harley J.B.... Kelly J.A. (2008)
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. (PubMed id 18204448)^{1, 2} Nath S.K.... Harley J.B. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. (PubMed id 15194813)^{1, 2} Zen K....Parkos C.A. (2004)
The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. (PubMed id 12208882)^{1, 2} Santoso S....Chavakis T. (2002)
Cation binding to the integrin CD11b I domain and activation model assessment. (PubMed id 9687375)^{1, 2} Baldwin E.T.... Wiley V.H. (1998)
Experimental support for a beta-propeller domain in integrin alpha- subunits and a calcium binding site on its lower surface. (PubMed id 9560195)^{1, 2} Oxvig C. and Springer T.A. (1998)
Two conformations of the integrin A-domain (I-domain): a pathway for activation? (PubMed id 8747460)^{1, 2} Lee J.O.... Liddington R.C. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3684	HGNC: 6149	AceView: ITGAM	Ensembl:ENSG00000169896	euGenes: HUgn3684
ECgene: ITGAM	Kegg: 3684	H-InvDB: ITGAM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGAM	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGAM	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGAM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGAM gene:
Search GeneIP for patents involving ITGAM

GeneCards and IP:
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ITGAM Gene

integrin, alpha M (complement component 3 receptor 3 subunit)

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ITGAM (Gene Symbol)
Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)
CD11B
CR3A
MAC-1
Cell Surface Glycoprotein MAC-1 Subunit Alpha
Leukocyte Adhesion Receptor MO1
CD11 Antigen-Like Family Member B
CR-3 Alpha Chain
MAC1A
SLEB6
CD11b
Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide)
MO1A
Antigen CD11b (P170)
Integrin Alpha-M
Macrophage Antigen Alpha Polypeptide
Neutrophil Adherence Receptor Alpha-M Subunit
CD11b Antigen
Neutrophil Adherence Receptor

sepsis
Acute myocardial infarction
Cystic Fibrosis
Dermatitis Atopic
Shock Hemorrhagic
Atherosclerosis
Respiratory Distress Syndrome
Edema
Hypercholesterolemia
AIDS
Asthma
cell damage
Bronchopulmonary Dysplasia
Shock
acute pancreatitis
Sarcoidosis Pulmonary
Inflammation
Tuberculosis
Monocytic leukemia
immunodeficiency
Neutropenia
Pulmonary Disease Chronic Obstructive
MYELOMA
Sarcoidosis
Rheumatoid Arthritis
Pneumonia
Tumors
Thrombosis
Necrosis
Lymphoblastic Leukemia Acute
Asthma allergic
Lichen Planus
virus infection
Preeclampsia
Coronary Heart Disease
Shock Septic
Myeloid Leukemia
promyelocytic leukemia
Vasculitis
Abscess
Venous Thrombosis
Systemic Inflammatory Response Syndrome
Lung Diseases Interstitial
PULMONARY INFECTION
Leukocytosis
Bacterial Infections
Carcinoma
INFARCT
ACUTE LEUKEMIA
Leukemia
Diabetes Mellitus
Leukopenia
Airway Obstruction
Postoperative Complications
Agranulocytosis
SEPSIS NEONATAL
Myocardial Infarction
Uremia
Multiple Organ Failure
HIV Infections
Eosinophilia
Septicemia
Lung diseases
Gastritis
restenosis
SKIN LESION
Shwartzman Reaction
Vascular Diseases
Community-Acquired Infections
Lymphoma Non-Hodgkins
LEUKAEMIA LYMPHOCYTIC
Renal Failure Chronic
Lupus Erythematosus Systemic

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ITGAM Gene

integrin, alpha M (complement component 3 receptor 3 subunit)

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