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ITGAM Gene

protein-coding   GIFtS: 67
GCID: GC16P031271

Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)

(Previous names: integrin, alpha M (complement component receptor 3, alpha;...)
(Previous symbols: CR3A, CD11B)
  See ITGAM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)1 2     Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As
CD11b (P170), Macrophage Antigen Alpha Polypeptide)1
CD11B1 2 3 5     MAC-12
CR3A1 2 3 5     MO1A2
Cell Surface Glycoprotein MAC-1 Subunit Alpha2 3     Antigen CD11b (P170)2
Leukocyte Adhesion Receptor MO12 3     Integrin Alpha-M2
CD11 Antigen-Like Family Member B2 3     Macrophage Antigen Alpha Polypeptide2
CR-3 Alpha Chain2 3     Neutrophil Adherence Receptor Alpha-M Subunit2
MAC1A2 5     CD11b Antigen3
SLEB62 5     Neutrophil Adherence Receptor3

External Ids:    HGNC: 61491   Entrez Gene: 36842   Ensembl: ENSG000001698967   OMIM: 1209805   UniProtKB: P112153   

Export aliases for ITGAM gene to outside databases

Previous GC identifers: GC16P030449 GC16P031767 GC16P031268 GC16P031307 GC16P031168 GC16P028833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGAM Gene:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of
an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2)
to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b)
receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to
stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for ITGAM Gene:
ITGAM (integrin, alpha M (complement component 3 receptor 3 subunit)) is a protein-coding gene. Diseases associated with ITGAM include systemic lupus erythematous, association with 6, and granulocytopenia. GO annotations related to this gene include heparin binding and heparan sulfate proteoglycan binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215
Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and
granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the
receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in
C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2
peptides of fibrinogen gamma chain

Gene Wiki entry for ITGAM (Integrin alpha M) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGAM gene promoter:
         C/EBPbeta   Sp1   AP-1   ATF-2   Lmo2   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGAM promoter sequence
   Search Chromatin IP Primers for ITGAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ITGAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAM gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031271:  view genomic region     (about GC identifiers)

Start:
31,271,288 bp from pter      End:
31,344,213 bp from pter
Size:
72,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215 (See protein sequence)
Recommended Name: Integrin alpha-M precursor  
Size: 1152 amino acids; 127179 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3
Selected PDB 3D structures from and Proteopedia for ITGAM (see all 15):
1A8X (3D)        1BHO (3D)        1BHQ (3D)        1IDN (3D)        1IDO (3D)        1JLM (3D)    
Secondary accessions: Q4VAK0 Q4VAK1 Q4VAK2
Alternative splicing: 2 isoforms:  P11215-1   P11215-2   

Explore the universe of human proteins at neXtProt for ITGAM: NX_P11215

Explore proteomics data for ITGAM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn86, Asn240, Asn391, Asn469, Asn692, Asn696, Asn734, Asn801, Asn880, Asn900,
                                 Asn911, Asn940, Asn946, Asn978, Asn993, Asn1021, Asn1044, Asn1050, Asn1075
  • Modification sites at PhosphoSitePlus

  • See ITGAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000623.2  NP_001139280.1  

    ENSEMBL proteins: 
     ENSP00000287497   ENSP00000441691   ENSP00000454568   ENSP00000461850  
    Reactome Protein details: P11215

    ITGAM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGAM (Integrin alpha M beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAM
    OriGene Protein Over-expression Lysate for ITGAM
    OriGene MassSpec for ITGAM
    OriGene Custom Protein Services for ITGAM
    GenScript Custom Purified and Recombinant Proteins Services for ITGAM
    Novus Biologicals ITGAM Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ITGAM
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGAM 

    ITGAM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAM
    R&D Systems Antibodies for ITGAM (Integrin alpha M/CD11b)
    OriGene Antibodies for ITGAM
    OriGene Custom Antibody Services for ITGAM
    Novus Biologicals ITGAM Antibodies
    Abcam antibodies for ITGAM (P11215, P05107)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGAM
    LSBio Antibodies in human, mouse, rat for ITGAM

    ITGAM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for ITGAM (Integrin alpha M/CD11b)
    GenScript Custom Assay Services for ITGAM
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGAM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins
    complement: Complement system

    Selected InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P11215

    ProtoNet protein and cluster: P11215

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGAM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAM_HUMAN, P11215
    Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and
    granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the
    receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in
    C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2
    peptides of fibrinogen gamma chain

         Genatlas biochemistry entry for ITGAM:
    integrin,alpha M,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB2 in vitronectin,fibrinogen,von Willebrand
    factor,thrombospondin,fibronectin,osteopontin,collagen

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001846opsonin binding IEA--
    GO:0001948glycoprotein binding IPI15004192
    GO:0005515protein binding IPI15194813
    GO:0008201heparin binding IEA--
    GO:0043395heparan sulfate proteoglycan binding IEA--
         
    Find genes that share ontologies with ITGAM           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itgam):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 

    Find genes that share phenotypes with ITGAM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ITGAM: Itgamtm1Rws Itgamtm1Myd Itgamtm1Bll

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGAM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGAM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAM

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ITGAM using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ITGAM:
    hsa-miR-661 hsa-miR-3941 hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidITGAM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGAM
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAM

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAM (see all 12)
    OriGene ORF clones in mouse, rat for ITGAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAM (NM_000632)
    Sino Biological Human cDNA Clone for ITGAM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAM
    Addgene plasmids for ITGAM 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAM

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10313) for ITGAM 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITAM_HUMAN, P11215: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytoskeleton2
    golgi apparatus2
    lysosome2
    nucleus2
    vacuole2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----

    Find genes that share ontologies with ITGAM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGAM About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with ITGAM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGAM (see all 36)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGAM
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Role of integrins in NK cells cytotoxicity
    Immune response Lectin induced complement pathway

    4 BioSystems Pathways for ITGAM
        Focal Adhesion
    Integrin-mediated cell adhesion
    IL-5 Signaling Pathway
    amb2 Integrin signaling


    3 Reactome Pathways for ITGAM
        Integrin cell surface interactions
    Toll Like Receptor 4 (TLR4) Cascade
    Cell surface interactions at the vascular wall


    Selected Kegg Pathways  (Kegg details for ITGAM) (see all 13):
        Rap1 signaling pathway
    Phagosome
    Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage
    Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAM (see all 9): 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGAM (P112152, 3 ENSP000002874974) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLEC4MQ9H2X32, 3, ENSP000003162284MINT-72825 MINT-72823 I2D: score=1 STRING: ENSP00000316228
    ITGB2P051073, ENSP000003032424I2D: score=5 STRING: ENSP00000303242
    ICAM1P053623, ENSP000002648324I2D: score=3 STRING: ENSP00000264832
    IRAK1P516173, ENSP000003589974I2D: score=3 STRING: ENSP00000358997
    JAM3Q9BX673, ENSP000002991064I2D: score=2 STRING: ENSP00000299106
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0007155cell adhesion TAS2563162
    GO:0007159leukocyte cell-cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with ITGAM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGAM (ITAM)

    Selected Novoseek inferred chemical compound relationships for ITGAM gene (see all 116)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 81.8 92 1672890 (5), 20348036 (4), 16249234 (4), 8100744 (3) (see all 53)
    n-formylmethionyl-leucylphenylalanine 75.2 22 10500036 (2), 7508644 (1), 1680065 (1), 15673886 (1) (see all 18)
    cuprophan 66.3 15 9890318 (3), 8079969 (3), 8770974 (2), 1292337 (1) (see all 8)
    nitroblue tetrazolium 65.6 18 8947589 (2), 12618899 (1), 2359342 (1), 8260698 (1) (see all 10)
    5-oxoete 64.6 6 9300719 (3), 11174193 (1), 19164129 (1), 18292294 (1)
    kh 1060 58.3 3 9823949 (2)
    bwa868c 56.5 1 11535533 (1)
    retinoic acid 54.2 30 17561254 (3), 9067636 (2), 9823949 (2), 17917245 (2) (see all 18)
    leukotriene b4 52.4 15 14722206 (3), 19048279 (2), 8926047 (2), 12952263 (1) (see all 7)
    fibrinogen 52.3 51 16241954 (4), 12469900 (2), 19281927 (2), 10353467 (2) (see all 31)



    Find genes that share compounds with ITGAM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGAM gene (2 alternative transcripts): 
    NM_000632.3  NM_001145808.1  

    Unigene Cluster for ITGAM:

    Integrin, alpha M (complement component 3 receptor 3 subunit)
    Hs.172631  [show with all ESTs]
    Unigene Representative Sequence: NM_001145808
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287497(uc010cam.1 uc002ebs.1) ENST00000544665(uc002ebq.3 uc002ebr.3 uc010can.3)
    ENST00000570242 ENST00000567031 ENST00000561838 ENST00000567178 ENST00000569746
    ENST00000565142
    miRNA
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    hsa-miR-661 hsa-miR-3941 hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidITGAM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ITGAM
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    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAM (NM_000632)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAM
    Addgene plasmids for ITGAM 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAM
      QuantiTect SYBR Green Assays in human, mouse, rat ITGAM
      QuantiFast Probe-based Assays in human, mouse, rat ITGAM
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10313) for ITGAM 

    Additional mRNA sequence: 

    AK057856.1 AK127637.1 AY187247.1 AY187248.1 BC096346.3 BC096347.3 BC096348.3 BC099660.3 
    J03925.1 J04145.1 M18044.1 

    8 DOTS entries:

    DT.410499  DT.87016127  DT.95144732  DT.91711441  DT.92422257  DT.91883151  DT.95295494  DT.95342181 

    Selected AceView cDNA sequences (see all 93):

    BI022050 AY187247 BP366620 M18044 AY187248 BF933045 AK057856 BF901924 
    BU684507 BG057336 BI031616 BV185719 BM992311 AI631857 J04145 AK127637 
    BI028552 BX644572 BV185718 BP362919 BV185720 AW401751 BI018134 BQ004580 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAM    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                                                                                                            
    SP2:                                            -     -     -     -     -     -     -     -     -     -           -                                             
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                             

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:        -                                                   
    SP2:        -                                                   
    SP3:                                                            


    ECgene alternative splicing isoforms for ITGAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ITGAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGCCGTG
    ITGAM Expression
    About this image


    ITGAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 12 entries
             Monocytes Peripheral Blood
             Facilitating cells
             Monocyte-like cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Hofbauer Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells
     
     Chorion (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    ITGAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172631

    UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215
    Tissue specificity: Predominantly expressed in monocytes and granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAM (see all 9): 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAM
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGAM gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgam1 , 5 integrin alpha M1, 5 78.61(n)1
    74.93(a)1
      7 (69.93 cM)5
    164091  NM_001082960.11  NP_001076429.11 
     1280626405 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    47(a)
    47(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343287.1(369977-372197)
    GL343220.1(2388207-2422669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itgad1 integrin, alpha D 52.48(n)
    43.73(a)
      101731775  XM_004918150.1  XP_004918207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018825851 integrin alpha-X-like 47.15(n)
    38.26(a)
      101882585  XM_005156007.1  XP_005156064.1 


    ENSEMBL Gene Tree for ITGAM (if available)
    TreeFam Gene Tree for ITGAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGAM gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGAM using alignment to 3 protein entries:     ITAM_HUMAN (see all proteins):
    ITGAD    ITGAX    FLJ00114    ITGAL

    Find genes that share paralogs with ITGAM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGAM (see all 1589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116416241,2
    C,F,A,H--28830490(+) CACCAT/CACCTG 2 -- us2k121Minor allele frequency- C:0.31NS EA WA NA CSA 2230
    rs133374271,2
    C--31273670(+) cttccA/Ttcctt 2 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs583174461,2
    C--31275174(+) TTATT-/TATT/ 
    TATTTATT
    GAGAT
    2 -- int11NA 2
    rs620514621,2
    C,F--31275409(+) GCCTCG/AGCCTC 2 -- int11Minor allele frequency- A:0.50NA 2
    rs579697161,2
    C--31276566(+) TTTTT-/TCTTTG 2 -- int10--------
    rs105261781,2
    C--31278206(+) ttttt-/TTTTT 
     TTTTTTT
    gaggc
    4 -- int1 cds11Minor allele frequency- TTTTTTTTTTTT:0.00NA 2
    rs1409979971,2
    C--31281482(+) TCCTT-/TC    
       CTTTC
    CTTTC
    2 -- int10--------
    rs118617711,2
    H--31283784(+) tatatA/TtTTTT 2 -- int10--------
    rs80620721,2
    A--31283786(+) TATATA/TTTTTT 2 -- int1 trp30--------
    rs2012259431,2
    C--31284618(+) AAAAA-/ACTAGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ITGAM (31271288 - 31344213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ITGAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2052288CNV Deletion18987734
    esv2714193CNV Deletion23290073
    esv1039007CNV Deletion17803354
    esv2436135CNV Deletion19546169

    Human Gene Mutation Database (HGMD): ITGAM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAM
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120980   
    OMIM disorders: 609939  
    UniProtKB/Swiss-Prot: ITAM_HUMAN, P11215
  • Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often
    febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin,
    joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the
    regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an
    elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility may be associated with variations affecting the gene represented in this entry

  • 10 diseases for ITGAM:    
    About MalaCards
    systemic lupus erythematous, association with 6    granulocytopenia    lymphocytic vasculitis    sepsis
    bronchopulmonary dysplasia    leukocyte adhesion deficiency    lichen planus    vasculitis
    acute promyelocytic leukemia    myocardial infarction

    8 diseases from the University of Copenhagen DISEASES database for ITGAM:
    Leukemia     Vascular disease     Leukocyte adhesion deficiency     Leukopenia
    Asthma     Arthritis     Respiratory failure     Hypersensitivity reaction type II disease

    Find genes that share disorders with ITGAM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGAM gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 58.5 44 15104334 (5), 11920354 (4), 10029565 (3), 15217824 (1) (see all 28)
    shwartzman reaction 48.3 1 18424751 (1)
    necrosis 48.3 34 11408721 (2), 8394087 (1), 12431190 (1), 7517990 (1) (see all 30)
    leukemia 45.9 5 10978780 (1), 17561254 (1), 7579392 (1), 18173208 (1) (see all 5)
    myeloid leukemia 45 2 11893077 (2)
    promyelocytic leukemia 44.2 1 19415458 (1)
    sepsis 38.3 18 8554683 (2), 16670636 (2), 11433091 (2), 9529172 (1) (see all 13)
    agranulocytosis 32.3 4 8856254 (2), 1292337 (1), 7490516 (1)
    systemic inflammatory response syndrome 27.5 1 10545303 (1)
    monocytic leukemia 25.6 1 20438701 (1)

    Genetic Association Database (GAD): ITGAM
    Human Genome Epidemiology (HuGE) Navigator: ITGAM (28 documents)

    Export disorders for ITGAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGAM gene, integrated from 10 sources (see all 1002):
    (articles sorted by number of sources associating them with ITGAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PubMed id 18204446)1, 2, 4 Harley J.B.... Kelly J.A. (Nat. Genet. 2008)
    2. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. (PubMed id 18204448)1, 2, 4 Nath S.K.... Harley J.B. (Nat. Genet. 2008)
    3. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. (PubMed id 1683702)1, 2, 9 Shelley C.S. and Arnaout M.A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    4. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). (PubMed id 19129174)1, 4, 9 Han S....Nath S.K. (Hum. Mol. Genet. 2009)
    5. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)1, 4, 9 Hom G....Behrens T.W. (N. Engl. J. Med. 2008)
    6. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)1, 4, 9 Hellmig S....Schreiber S. (Tissue Antigens 2005)
    7. ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population. (PubMed id 20666624)1, 4 WarchoA8 T....JagodziA8ski P.P. (DNA Cell Biol. 2011)
    8. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    9. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (PLoS Genet. 2011)
    10. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (Ann. Rheum. Dis. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3684 HGNC: 6149 AceView: ITGAM Ensembl:ENSG00000169896 euGenes: HUgn3684
    ECgene: ITGAM Kegg: 3684 H-InvDB: ITGAM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGAM gene:
    Search GeneIP for patents involving ITGAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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