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Aliases for ITGAL Gene

Aliases for ITGAL Gene

  • Integrin Subunit Alpha L 2 3 5
  • Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide) 2 3
  • Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 2 3
  • Leukocyte Function-Associated Molecule 1 Alpha Chain 3 4
  • Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain 3 4
  • CD11 Antigen-Like Family Member A 3 4
  • Antigen CD11A (P180) 2 3
  • LFA-1A 3 4
  • CD11A 3 4
  • Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 3
  • Lymphocyte Function-Associated Antigen 1 3
  • Integrin Gene Promoter 3
  • Integrin Alpha-L 3
  • CD11a Antigen 4
  • LFA-1 Alpha 3
  • LFA-1 3
  • LFA1A 3

External Ids for ITGAL Gene

Previous HGNC Symbols for ITGAL Gene

  • CD11A

Previous GeneCards Identifiers for ITGAL Gene

  • GC16P029766
  • GC16P030972
  • GC16P030480
  • GC16P030520
  • GC16P030391
  • GC16P028046

Summaries for ITGAL Gene

Entrez Gene Summary for ITGAL Gene

  • ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGAL Gene

ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. Diseases associated with ITGAL include Benign Cephalic Histiocytosis and Leukocyte Adhesion Deficiency. Among its related pathways are HTLV-I infection and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include protein heterodimerization activity and cell adhesion molecule binding. An important paralog of this gene is ITGAX.

UniProtKB/Swiss-Prot for ITGAL Gene

  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Gene Wiki entry for ITGAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAL Gene

Genomics for ITGAL Gene

Regulatory Elements for ITGAL Gene


Enhancers around ITGAL on UCSC Golden Path with GeneCards custom track

Promoters for ITGAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051804 642 1401 HDGF ELF3 TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A ARID4B YBX1 ZNF48

Transcription factor binding sites by QIAGEN in the ITGAL gene promoter:

Genomic Location for ITGAL Gene

Chromosome:
16
Start:
30,472,658 bp from pter
End:
30,523,185 bp from pter
Size:
50,528 bases
Orientation:
Plus strand

Genomic View for ITGAL Gene

Genes around ITGAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAL Gene

Proteins for ITGAL Gene

  • Protein details for ITGAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20701-ITAL_HUMAN
    Recommended name:
    Integrin alpha-L
    Protein Accession:
    P20701
    Secondary Accessions:
    • O43746
    • Q45H73
    • Q96HB1
    • Q9UBC8

    Protein attributes for ITGAL Gene

    Size:
    1170 amino acids
    Molecular mass:
    128770 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit (PubMed:12526797). Alpha-L associates with beta-2 (PubMed:12526797). Interacts with THBD (PubMed:27055590).

    Three dimensional structures from OCA and Proteopedia for ITGAL Gene

    Alternative splice isoforms for ITGAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGAL Gene

Post-translational modifications for ITGAL Gene

  • In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
  • Ubiquitination at Lys 93, Lys 321, Lys 371, Lys 416, Lys 776, Lys 831, Lys 836, Lys 950, and Lys 664
  • Glycosylation at Asn 65, Asn 89, Asn 188, Asn 649, Asn 670, Asn 726, Asn 730, Asn 862, Asn 885, Asn 897, Asn 1060, and Asn 1071
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGAL Gene

Domains & Families for ITGAL Gene

Gene Families for ITGAL Gene

Graphical View of Domain Structure for InterPro Entry

P20701

UniProtKB/Swiss-Prot:

ITAL_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAL: view

Function for ITGAL Gene

Molecular function for ITGAL Gene

GENATLAS Biochemistry:
integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Gene Ontology (GO) - Molecular Function for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11544294
GO:0030369 ICAM-3 receptor activity IMP 19029120
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ITGAL: view
genes like me logo Genes that share phenotypes with ITGAL: view

Animal Models for ITGAL Gene

MGI Knock Outs for ITGAL:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAL
  • R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAL Gene

Localization for ITGAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAL Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAL Gene COMPARTMENTS Subcellular localization image for ITGAL gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0008305 integrin complex IEA,NAS 8103515
GO:0009986 cell surface IDA 19029120
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITGAL: view

Pathways & Interactions for ITGAL Gene

genes like me logo Genes that share pathways with ITGAL: view

Pathways by source for ITGAL Gene

Gene Ontology (GO) - Biological Process for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
GO:0006909 phagocytosis IEA --
GO:0006928 movement of cell or subcellular component TAS 10477596
GO:0006954 inflammatory response NAS 8103515
GO:0007155 cell adhesion IEA,NAS 8103515
genes like me logo Genes that share ontologies with ITGAL: view

No data available for SIGNOR curated interactions for ITGAL Gene

Drugs & Compounds for ITGAL Gene

(67) Drugs for ITGAL Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Efalizumab Approved, Investigational Pharma antibody, Target 0
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, Target, other/unknown HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 62
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target 0
LFA703 Experimental Pharma Target 0
(S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE Experimental Pharma Target 0

(38) Additional Compounds for ITGAL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ITGAL Gene

Compound Action Cas Number
A 286982 LFA-1/ICAM-1 interaction inhibitor 280749-17-9
genes like me logo Genes that share compounds with ITGAL: view

Transcripts for ITGAL Gene

Unigene Clusters for ITGAL Gene

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAL
  • R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for ITGAL Gene

GeneLoc Exon Structure for
ITGAL
ECgene alternative splicing isoforms for
ITGAL

Expression for ITGAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGAL Gene

This gene is overexpressed in Whole Blood (x25.6) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for ITGAL Gene

This gene is overexpressed in Lymph node (20.7), Tlymphocyte (13.6), Peripheral blood mononuclear cells (8.2), CD8 Tcells (7.4), and NK cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGAL Gene



Protein tissue co-expression partners for ITGAL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAL Gene:

ITGAL

SOURCE GeneReport for Unigene cluster for ITGAL Gene:

Hs.174103

mRNA Expression by UniProt/SwissProt for ITGAL Gene:

P20701-ITAL_HUMAN
Tissue specificity: Leukocytes.
genes like me logo Genes that share expression patterns with ITGAL: view

Primer Products

Orthologs for ITGAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAL 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ITGAL 34 35
  • 83.36 (n)
cow
(Bos Taurus)
Mammalia ITGAL 34 35
  • 82.66 (n)
rat
(Rattus norvegicus)
Mammalia Itgal 34
  • 78.28 (n)
mouse
(Mus musculus)
Mammalia Itgal 34 16 35
  • 77.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ITGAL 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGAL 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGAL 35
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zmp:0000001082 34
  • 48.58 (n)
ITGAL 35
  • 30 (a)
OneToOne
Species where no ortholog for ITGAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAL Gene

ENSEMBL:
Gene Tree for ITGAL (if available)
TreeFam:
Gene Tree for ITGAL (if available)

Paralogs for ITGAL Gene

(3) SIMAP similar genes for ITGAL Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ITGAL: view

Variants for ITGAL Gene

Sequence variations from dbSNP and Humsavar for ITGAL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1064524 -- 30,481,502(+) TTAAA(C/T)GGAAG nc-transcript-variant, reference, missense
rs1064525 -- 30,522,575(+) GATGA(C/T)GCCTC utr-variant-3-prime
rs1064526 -- 30,522,579(+) ATGCC(G/T)CATGA utr-variant-3-prime
rs10871452 -- 30,481,369(+) AAAAG(A/C)AGTAG intron-variant
rs111290078 -- 30,493,078(+) GACGG(C/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAL Gene

Variant ID Type Subtype PubMed ID
nsv1116127 CNV deletion 24896259
nsv1127486 CNV deletion 24896259
nsv1783 CNV deletion 18451855
nsv1784 CNV insertion 18451855

Variation tolerance for ITGAL Gene

Residual Variation Intolerance Score: 3.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAL Gene

Disorders for ITGAL Gene

MalaCards: The human disease database

(15) MalaCards diseases for ITGAL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
benign cephalic histiocytosis
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency, type iii
lichen planus
  • lichen planus nos
guttate psoriasis
  • psoriasis guttate
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search ITGAL in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAL

Genetic Association Database (GAD)
ITGAL
Human Genome Epidemiology (HuGE) Navigator
ITGAL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAL
genes like me logo Genes that share disorders with ITGAL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAL Gene

Publications for ITGAL Gene

  1. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PMID: 10493852) Kallen J. … Hommel U. (J. Mol. Biol. 1999) 3 4 22 25 64
  2. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PMID: 8097887) Cornwell R.D. … Hickstein D.D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64
  3. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PMID: 8103515) Nueda A. … Corbi A.L. (J. Biol. Chem. 1993) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PMID: 15730520) Hellmig S. … Schreiber S. (Tissue Antigens 2005) 3 46 64

Products for ITGAL Gene

Sources for ITGAL Gene

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