Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGAL Gene

protein-coding   GIFtS: 70
GCID: GC16P030483

Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated...


(Previous symbol: CD11A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated
Antigen 1; Alpha Polypeptide)1 2
     LFA-12
CD11A1 2 3 5     Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha
Polypeptide2
Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain2 3     Integrin Alpha-L2
Leukocyte Function-Associated Molecule 1 Alpha Chain2 3     Integrin Gene Promoter2
LFA-1A2 3     LFA-1 Alpha2
CD11 Antigen-Like Family Member A2 3     Lymphocyte Function-Associated Antigen 12
LFA1A2 5     CD11a Antigen3

External Ids:    HGNC: 61481   Entrez Gene: 36832   Ensembl: ENSG000000058447   OMIM: 1533705   UniProtKB: P207013   

Export aliases for ITGAL gene to outside databases

Previous GC identifers: GC16P029766 GC16P030972 GC16P030480 GC16P030520 GC16P030391 GC16P028046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAL Gene:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an
alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to
form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1
plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3
(intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGAL Gene: 
ITGAL (integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)) is a protein-coding gene. Diseases associated with ITGAL include cutaneous necrotizing vasculitis, and benign cephalic histiocytosis, and among its related super-pathways are Integrin-mediated cell adhesion and FAK1 Signaling. GO annotations related to this gene include cell adhesion molecule binding and metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of
immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and
antibody dependent killing by granulocytes and monocytes

Gene Wiki entry for ITGAL (CD11a) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGAL gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAL promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p13.1-p11

ITGAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030483:  view genomic region     (about GC identifiers)

Start:
30,483,979 bp from pter      End:
30,534,506 bp from pter
Size:
50,528 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701 (See protein sequence)
Recommended Name: Integrin alpha-L precursor  
Size: 1170 amino acids; 128770 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2
Subcellular location: Membrane; Single-pass type I membrane protein
6/30 PDB 3D structures from and Proteopedia for ITGAL (see all 30):
1CQP (3D)        1DGQ (3D)        1IJ4 (3D)        1LFA (3D)        1MJN (3D)        1MQ8 (3D)    
Secondary accessions: O43746 Q45H73 Q96HB1 Q9UBC8
Alternative splicing: 3 isoforms:  P20701-1   P20701-2   P20701-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGAL: NX_P20701

Explore proteomics data for ITGAL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20701

  • ITGAL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGAL Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107852.1  NP_002200.2  

    ENSEMBL proteins: 
     ENSP00000349252   ENSP00000456521   ENSP00000350886   ENSP00000457785   ENSP00000454908  
     ENSP00000454342   ENSP00000456888   ENSP00000409377   ENSP00000461006   ENSP00000458739  
     ENSP00000408615  
    Reactome Protein details: P20701
    Human Recombinant Protein Products for ITGAL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGAL (Integrin alpha L beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAL
    OriGene Protein Over-expression Lysate for ITGAL
    OriGene MassSpec for ITGAL 
    OriGene Custom Protein Services for ITGAL
    GenScript Custom Purified and Recombinant Proteins Services for ITGAL
    Novus Biologicals ITGAL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex NAS8103515
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane ----

    ITGAL for ontologies           About GeneDecksing



    ITGAL Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ITGAL (Integrin alpha L/CD11a)
    OriGene Antibodies for ITGAL
    OriGene Custom Antibody Services for ITGAL
    GenScript Custom Superior Antibodies Services for ITGAL
    Novus Biologicals ITGAL Antibodies
    Abcam antibodies for ITGAL
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for ITGAL
    LSBio Antibodies in human, mouse, rat for ITGAL 

    Assay Products for ITGAL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAL
    R&D Systems Proteome Profiler Antibody Arrays for ITGAL (Integrin alpha L/CD11a)
    GenScript Custom Assay Services for ITGAL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5/6 InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P20701

    ProtoNet protein and cluster: P20701

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGAL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAL_HUMAN, P20701
    Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of
    immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and
    antibody dependent killing by granulocytes and monocytes

         Genatlas biochemistry entry for ITGAL:
    integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15946252
    GO:0046872metal ion binding IEA--
    GO:0050839cell adhesion molecule binding IPI1448173
         
    ITGAL for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ITGAL:
     Decreased number of cells in m  G0/1 arrest  Increased G1 DNA content  Increased cell size 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Itgal):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    ITGAL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGAL: Itgaltm1Mak Itgaltm1Hlz Itgaltm1Wpfl Itgaltm1Bll

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAL
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAL (see all 15):
    hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidITGAL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAL
    Sirion Biotech Customized adenovirus for overexpression of ITGAL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGAL (see all 11)
    OriGene ORF clones in mouse, rat for ITGAL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
    Sino Biological Human cDNA Clone for ITGAL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAL 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAL
    Search LifeMap BioReagents cell lines for ITGAL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGAL About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ITGAL
        Immune response Role of integrins in NK cells cytotoxicity
    Cell adhesion Integrin inside-out signaling

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAL (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 GeneGo (Thomson Reuters) Pathways for ITGAL
        Cell adhesion Integrin inside-out signaling
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response Role of integrins in NK cells cytotoxicity

    4 BioSystems Pathways for ITGAL
        Focal Adhesion
    Integrin-mediated cell adhesion
    CXCR3-mediated signaling events
    Paxillin-dependent events mediated by a4b1


    5/7        Reactome Pathways for ITGAL (see all 7)
        Hemostasis
    Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System


    5/10         Kegg Pathways  (Kegg details for ITGAL) (see all 10):
        Cell adhesion molecules (CAMs)
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton
    Malaria


    ITGAL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for ITGAL (P207012, 3 ENSP000003492524) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRCP085752, 3, ENSP000003563464MINT-8213340 MINT-8213325 I2D: score=4 STRING: ENSP00000356346
    RANBP9Q96S592, 3, ENSP000000116194MINT-50056 MINT-50070 I2D: score=3 STRING: ENSP00000011619
    ENSG00000206379O759553I2D: score=1 
    ENSG00000206480O759553I2D: score=1 
    ENSG00000230143O759553I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP2477710
    GO:0006928cellular component movement TAS10477596
    GO:0006954inflammatory response NAS8103515
    GO:0007155cell adhesion NAS8103515
    GO:0007157heterophilic cell-cell adhesion IMP2477710

    ITGAL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGAL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGAL (ITAL)

    8 DrugBank Compounds for ITGAL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Efalizumabanti alphaL integrin (see all 4)214745-43-4targetantibody17053736 11752352 19170413
    1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine-- --target--17139284 17016423
    LFA703-- --target--17139284 17016423
    3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline-- --target--10592235
    7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile-- --target--10592235
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600
    Lovastatin6 alpha-Methylcompactin (see all 4)75330-75-5targetother/unknown10493852
    (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE-- --target----

    10/96 Novoseek inferred chemical compound relationships for ITGAL gene (see all 96)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    efalizumab 78.4 30 17167274 (2), 17587888 (2), 14627785 (1), 18341848 (1) (see all 21)
    lfa703 70.8 3 15161667 (1), 15618295 (1)
    slex 66.6 25 12845988 (2), 16689823 (1), 7541055 (1), 7487990 (1) (see all 14)
    celgosivir 61.6 1 7780199 (1)
    nkh 1 52.3 2 1905985 (1), 10541572 (1)
    slea 52 1 9430509 (1)
    cytochalasin b 48.3 8 18069239 (1), 9083889 (1), 2246503 (1), 10672935 (1) (see all 5)
    phorbol 42.5 5 9765268 (2), 9735343 (1), 10531396 (1), 10634414 (1)
    cuprophan 40.2 1 8770974 (1)
    fmlp 38.6 5 1680065 (2), 8707129 (1), 12198042 (1), 10464825 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGAL / ITAL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGAL gene (2 alternative transcripts): 
    NM_001114380.1  NM_002209.2  

    Unigene Cluster for ITGAL:

    Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
    Hs.174103  [show with all ESTs]
    Unigene Representative Sequence: NM_002209
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000356798(uc010veu.1) ENST00000562652 ENST00000569570 ENST00000358164(uc002dyi.4 uc002dyj.4 uc010vev.2)
    ENST00000568926 ENST00000565864 ENST00000562857 ENST00000565348 ENST00000564118
    ENST00000433423 ENST00000569725 ENST00000566149 ENST00000568012 ENST00000564935
    ENST00000568987 ENST00000563615 ENST00000562020 ENST00000566267
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAL
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAL (see all 15):
    hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidITGAL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAL
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAL (see all 11)
    OriGene ORF clones in mouse, rat for ITGAL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAL 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAL

    Additional mRNA sequence: 

    AK298674.1 AK303190.1 AK314246.1 BC008777.2 Y00796.1 

    16 DOTS entries:

    DT.455112  DT.99976275  DT.100684944  DT.120672226  DT.120672197  DT.40113484  DT.86855467  DT.86859420 
    DT.91659930  DT.101967087  DT.120672194  DT.91742949  DT.95184191  DT.92057784  DT.95184188  DT.95329677 

    24/121 AceView cDNA sequences (see all 121):

    AW505283 AX794819 CA430398 BM819802 BC008777 AW502592 BM853879 AW576571 
    AW502651 AI350394 AX794818 BM768725 CF142739 BX114703 BV167398 BG744200 
    BX485565 Y00796 BM151337 BU430141 CA309449 BX457402 BM149473 BI769098 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                -     -           -                                                                                                         
    SP2:                                -     -           -                       -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                -     -           -     -     -     -                                                                                       
    SP5:                                                  -                                                                                                         

    ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:  -                                                                                                               
    SP2:  -                                                                                                               
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ITGAL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGAL expression in normal human tissues (normalized intensities)      ITGAL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATCCA
    ITGAL Expression
    About this image


    ITGAL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             cd4+ t cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Bone (Muscoskeletal System)
             BONE MARROW   

    See ITGAL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGAL

    SOURCE GeneReport for Unigene cluster: Hs.174103

    UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
    Tissue specificity: Leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGAL: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGAL gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgal1 , 5 integrin alpha L1, 5 77.81(n)1
    73.11(a)1
      7 (69.44 cM)5
    164081  NM_001253872.11  NP_001240801.11 
     1272962605 
    lizard
    (Anolis carolinensis)
    Reptilia ITGAL6
    integrin, alpha L (antigen CD11A (p180), lymphocyt...
    41(a)
    1 ↔ 1
    GL343516.1(235225-282822)
    zebrafish
    (Danio rerio)
    Actinopterygii ITGAL6
    integrin, alpha L (antigen CD11A (p180), lymphocyt...
    29(a)
    1 ↔ 1
    1(60006661-60019406)
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS56
    scb6
    (see all 3)
    scab
    (see all 3)
    19(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(19444333-19447720)
    2R(11136290-11146003)


    ENSEMBL Gene Tree for ITGAL (if available)
    TreeFam Gene Tree for ITGAL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGAL gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGA92  ITGA102  
    ITGA42  
    3 SIMAP similar genes for ITGAL using alignment to 9 protein entries:     ITAL_HUMAN (see all proteins):
    ITGAM    ITGAD    ITGAX

    ITGAL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/982 SNPs in ITGAL are shown (see all 982)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124461701,2
    H--30481996(+) gagccA/Cccatg 2 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs3677807761,2
    C--30482090(+) GAGGCA/GGCAAA 2 -- us2k10--------
    rs1405548701,2
    --30482203(+) AGTTCC/TAGCTA 2 -- us2k10--------
    rs1856879141,2
    --30482216(+) CAGGAC/TGCTGA 2 -- us2k10--------
    rs1881171241,2
    --30482244(+) AGCCCG/TTGAGG 2 -- us2k10--------
    rs1133030751,2
    C,F--30482393(+) GCCAGC/AAATGT 2 -- us2k12Minor allele frequency- A:0.06NA 122
    rs111505891,2
    C,F,A,H--30482494(+) cactgC/Tggttt 2 -- us2k1 tfbs320Minor allele frequency- T:0.45NS EA NA WA 2344
    rs125989781,2
    C,F,A,H--30482540(+) tatcaG/Tttcat 2 -- us2k122Minor allele frequency- T:0.45NS EA NA WA 2582
    rs1162161491,2
    C,F--30482564(+) ATTTAT/CATGTC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1810133171,2
    --30482771(+) TCAAGC/TAGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGAL (30483979 - 30534506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITGAL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1784CNV Insertion18451855
    nsv1783CNV Loss18451855
    nsv905726CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAL
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153370    OMIM disorders: --

    20/135 diseases for ITGAL (see all 135):    About MalaCards
    cutaneous necrotizing vasculitis    benign cephalic histiocytosis    lymph node cancer    actinic prurigo
    guttate psoriasis    immune-complex glomerulonephritis    leukocyte adhesion deficiency    sialadenitis
    pustulosis palmaris et plantaris    pasteurellosis    venous insufficiency    spondylarthropathy
    allergic conjunctivitis    coronary stenosis    lichen planus    ileus
    glomerulonephritis    mycosis fungoides    arteriosclerosis obliterans    lichen sclerosus

    5 diseases from the University of Copenhagen DISEASES database for ITGAL:
    Leukocyte adhesion deficiency     Psoriasis     Leukemia     Lymphoma
    Lung disease

    ITGAL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/88 Novoseek inferred disease relationships for ITGAL gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 58.1 21 1401271 (1), 14627785 (1), 11758117 (1), 17596165 (1) (see all 15)
    inflammation 52.1 46 11698049 (2), 10614768 (1), 10493852 (1), 11144049 (1) (see all 31)
    necrosis 49.8 35 8656013 (2), 8094958 (2), 10198263 (2), 8394087 (1) (see all 25)
    leukemia t-cell 34.5 5 7678112 (1), 7525481 (1), 7530239 (1), 11321434 (1)
    lichen planus 33.6 6 8784900 (3), 1348286 (1), 17034521 (1)
    tumors 30.6 74 9162263 (3), 10087180 (3), 1562732 (3), 8656013 (2) (see all 46)
    immunodeficiency 30.5 23 12921757 (2), 11134324 (2), 7847878 (1), 8656013 (1) (see all 18)
    skin diseases 29.6 3 11758117 (1), 7616000 (1), 1607407 (1)
    autoimmunity 28.7 8 12163700 (3), 1671565 (1), 11130783 (1)
    mycosis fungoides 28.7 2 7539248 (1), 8537552 (1)

    Genetic Association Database (GAD): ITGAL
    Human Genome Epidemiology (HuGE) Navigator: ITGAL (7 documents)

    Export disorders for ITGAL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGAL gene, integrated from 9 sources (see all 1090):
    (articles sorted by number of sources associating them with ITGAL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PubMed id 10493852)1, 2, 7, 9 Kallen J.... Hommel U. (1999)
    2. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PubMed id 8097887)1, 2, 9 Cornwell R.D.... Hickstein D.D. (1993)
    3. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PubMed id 8103515)1, 2, 9 Nueda A.... Corbi A.L. (1993)
    4. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)1, 4, 9 Hellmig S....Schreiber S. (2005)
    5. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. (PubMed id 8099450)1, 2, 9 Shelley C.S.... Arnaout M.A. (1993)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. (PubMed id 12526797)1, 2 Shimaoka M....Springer T.A. (2003)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    9. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. (PubMed id 8805579)1, 2 Qu A. and Leahy D.J. (1996)
    10. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. (PubMed id 7479767)1, 2 Qu A. and Leahy D.J. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3683 HGNC: 6148 AceView: ITGAL Ensembl:ENSG00000005844 euGenes: HUgn3683
    ECgene: ITGAL Kegg: 3683 H-InvDB: ITGAL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGAL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAL Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/itgal/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGAL gene:
    Search GeneIP for patents involving ITGAL

    Licensable Technologies for ITGAL gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITGAL (Integrin alpha L/CD11a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ITGAL (Integrin alpha L beta 2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ITGAL (Integrin alpha L/CD11a)  
     OriGene Antibodies for ITGAL   OriGene RNAi products in human, mouse, rat for ITGAL  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGAL  
     OriGene MassSpec something-or-other for ITGAL   OriGene clones in human, mouse for ITGAL  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGAL   OriGene Purified Protein for ITGAL  
     OriGene ORF clones in mouse, rat for ITGAL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGAL   OriGene Custom Protein Services for ITGAL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGAL
     QIAGEN SeqTarget long-range PCR primers for resequencing ITGAL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAL
     GenScript Custom Purified and Recombinant Proteins Services for ITGAL GenScript cDNA clones with any tag delivered in your preferred vector for ITGAL
     GenScript Custom Assay Services for ITGAL GenScript Custom Superior Antibodies Services for ITGAL
     GenScript Custom overexpressing Cell Line Services for ITGAL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITGAL promoter
     Search Chromatin IP Primers for ITGAL
     RT2 qPCR Primer Assay in human, mouse, rat ITGAL
     GNC Network for ITGAL
     SABiosciences PCR Arrays including human, mouse, rat ITGAL
     Search Tocris compounds for ITGAL (ITAL)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ITGAL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGAL antibodies
     ITGAL lysates
     Antibodies for ITGAL
     See all of Abcam's Antibodies, Kits and Proteins for ITGAL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ITGAL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAL
     SwitchGear 3'UTR luciferase reporter plasmids for ITGAL
     SwitchGear Promoter luciferase reporter plasmids for ITGAL
     ThermoFisher Antibody for ITGAL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAL
    Customized:
     lentivirus for stable overexpression of ITGAL
     lentivirus expression plasmids for stable overexpression of ITGAL
     adenovirus for overexpression of ITGAL
     LSBio Antibodies in human, mouse, rat for ITGAL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGAL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4