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Aliases for ITGAL Gene

Aliases for ITGAL Gene

  • Integrin Subunit Alpha L 2 3 5
  • Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide) 2 3
  • Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 2 3
  • Leukocyte Function-Associated Molecule 1 Alpha Chain 3 4
  • Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain 3 4
  • CD11 Antigen-Like Family Member A 3 4
  • LFA-1A 3 4
  • CD11A 3 4
  • Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 3
  • Integrin Gene Promoter 3
  • Antigen CD11A (P180) 2
  • Integrin Alpha-L 3
  • CD11a Antigen 4
  • LFA-1 Alpha 3
  • LFA-1 3
  • LFA1A 3

External Ids for ITGAL Gene

Previous HGNC Symbols for ITGAL Gene

  • CD11A

Previous GeneCards Identifiers for ITGAL Gene

  • GC16P029766
  • GC16P030972
  • GC16P030480
  • GC16P030520
  • GC16P030391
  • GC16P028046

Summaries for ITGAL Gene

Entrez Gene Summary for ITGAL Gene

  • ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGAL Gene

ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. Diseases associated with ITGAL include Benign Cephalic Histiocytosis and Leukocyte Adhesion Deficiency. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Akt Signaling. GO annotations related to this gene include protein heterodimerization activity and cell adhesion molecule binding. An important paralog of this gene is ITGAX.

UniProtKB/Swiss-Prot for ITGAL Gene

  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Gene Wiki entry for ITGAL Gene

Additional gene information for ITGAL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAL Gene

Genomics for ITGAL Gene

Regulatory Elements for ITGAL Gene

Enhancers for ITGAL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030547 1.5 Ensembl ENCODE dbSUPER 11.5 +76.3 76315 2 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS ATF7 NCOA1 ZNF689 ZNF764 SETD1A ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2
GH16H030538 1.5 Ensembl ENCODE dbSUPER 11.4 +68.7 68744 5 PKNOX1 ATF1 MLX ARNT ARID4B DMAP1 TCF12 ZNF121 ZNF302 FOS ZNF764 ZNF785 INO80E ENSG00000235560 SRCAP SMG1P2 ENSG00000260267 SMG1P5 ENSG00000260304 ENSG00000260114
GH16H030550 1.2 Ensembl ENCODE dbSUPER 10.5 +79.7 79738 2 BCOR HDAC1 PKNOX1 L3MBTL2 NR2F1 GATA3 MTA3 POLR2A IKZF1 KLF9 ZNF688 ZNF785 DCTPP1 ZNF689 SEPHS2 ITGAL ENSG00000222701 CD2BP2 ENSG00000235560 PIR49345
GH16H030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +97.2 97217 6 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A SETD1A SRCAP ENSG00000260267 ZNF747 NPIPB13 INO80E ZNF764 C16orf58 SMG1P5 SMG1P2
GH16H030589 0.9 ENCODE 11.7 +117.8 117825 1 ZNF493 ZFP64 ZEB1 TCF12 ZNF121 ZNF23 ZNF138 KLF7 ZNF548 ZNF202 SETD1A SRCAP ENSG00000260267 NPIPB13 C16orf58 FUS INO80E ZNF764 ZNF747 SMG1P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGAL on UCSC Golden Path with GeneCards custom track

Promoters for ITGAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085204 342 401 ELF3 HDGF PKNOX1 TBL1XR1 RB1 ARID4B RAD21 YY1 SCRT2 ATF7

Transcription factor binding sites by QIAGEN in the ITGAL gene promoter:

Genomic Location for ITGAL Gene

Chromosome:
16
Start:
30,472,658 bp from pter
End:
30,523,185 bp from pter
Size:
50,528 bases
Orientation:
Plus strand

Genomic View for ITGAL Gene

Genes around ITGAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAL Gene

Proteins for ITGAL Gene

  • Protein details for ITGAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20701-ITAL_HUMAN
    Recommended name:
    Integrin alpha-L
    Protein Accession:
    P20701
    Secondary Accessions:
    • O43746
    • Q45H73
    • Q96HB1
    • Q9UBC8

    Protein attributes for ITGAL Gene

    Size:
    1170 amino acids
    Molecular mass:
    128770 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit (PubMed:12526797). Alpha-L associates with beta-2 (PubMed:12526797). Interacts with THBD (PubMed:27055590).

    Three dimensional structures from OCA and Proteopedia for ITGAL Gene

    Alternative splice isoforms for ITGAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGAL Gene

Post-translational modifications for ITGAL Gene

  • In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
  • Ubiquitination at posLast=9393, isoforms=2, 3321, posLast=371371, isoforms=2, 3416, posLast=776776, posLast=831831, posLast=836836, isoforms=3950, and posLast=664664
  • Glycosylation at isoforms=2, 365, posLast=8989, posLast=188188, isoforms=2, 3649, posLast=670670, posLast=726726, isoforms=2, 3730, posLast=862862, posLast=885885, isoforms=2, 3897, isoforms=2, 31060, and posLast=10711071
  • Modification sites at PhosphoSitePlus

Assay Products

  • Cloud-Clone Corp. Assay Kits for ITGAL

No data available for DME Specific Peptides for ITGAL Gene

Domains & Families for ITGAL Gene

Gene Families for ITGAL Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P20701

UniProtKB/Swiss-Prot:

ITAL_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGAL: view

Function for ITGAL Gene

Molecular function for ITGAL Gene

GENATLAS Biochemistry:
integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Phenotypes From GWAS Catalog for ITGAL Gene

Gene Ontology (GO) - Molecular Function for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11544294
GO:0030369 ICAM-3 receptor activity IMP 19029120
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ITGAL: view
genes like me logo Genes that share phenotypes with ITGAL: view

Animal Models for ITGAL Gene

MGI Knock Outs for ITGAL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAL
  • Applied Biological Materials Clones for ITGAL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAL Gene

Localization for ITGAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAL Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGAL gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex NAS 8103515
GO:0009986 cell surface IDA 19029120
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITGAL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAL Gene

Pathways & Interactions for ITGAL Gene

genes like me logo Genes that share pathways with ITGAL: view

Gene Ontology (GO) - Biological Process for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
GO:0006909 phagocytosis IEA --
GO:0006928 movement of cell or subcellular component TAS 10477596
GO:0006954 inflammatory response NAS 8103515
GO:0007155 cell adhesion NAS 8103515
genes like me logo Genes that share ontologies with ITGAL: view

No data available for SIGNOR curated interactions for ITGAL Gene

Drugs & Compounds for ITGAL Gene

(69) Drugs for ITGAL Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Efalizumab Approved, Investigational Pharma antibody, Target 0
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, Target, other/unknown HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 67
Simvastatin Approved Pharma Competitive, Inhibitor, Target, inhibitor HMG-CoA reductase inhibitor 528
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target 0
Lifitegrast Approved Pharma Target, antagonist 0

(37) Additional Compounds for ITGAL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ITGAL Gene

Compound Action Cas Number
A 286982 LFA-1/ICAM-1 interaction inhibitor 280749-17-9
genes like me logo Genes that share compounds with ITGAL: view

Drug Products

Transcripts for ITGAL Gene

Unigene Clusters for ITGAL Gene

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGAL
  • Applied Biological Materials Clones for ITGAL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for ITGAL Gene

GeneLoc Exon Structure for
ITGAL
ECgene alternative splicing isoforms for
ITGAL

Expression for ITGAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGAL Gene

This gene is overexpressed in Whole Blood (x25.6) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for ITGAL Gene

This gene is overexpressed in Lymph node (20.7), Tlymphocyte (13.6), Peripheral blood mononuclear cells (8.2), CD8 Tcells (7.4), and NK cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGAL Gene



Protein tissue co-expression partners for ITGAL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAL Gene:

ITGAL

SOURCE GeneReport for Unigene cluster for ITGAL Gene:

Hs.174103

mRNA Expression by UniProt/SwissProt for ITGAL Gene:

P20701-ITAL_HUMAN
Tissue specificity: Leukocytes.

Evidence on tissue expression from TISSUES for ITGAL Gene

  • Blood(3.5)
  • Lymph node(3)
  • Spleen(2.9)
  • Bone marrow(2.8)
  • Heart(2.6)
  • Intestine(2.4)
  • Lung(2.4)
  • Skin(2)
genes like me logo Genes that share expression patterns with ITGAL: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAL Gene

Orthologs for ITGAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAL 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ITGAL 33 34
  • 83.36 (n)
cow
(Bos Taurus)
Mammalia ITGAL 33 34
  • 82.66 (n)
rat
(Rattus norvegicus)
Mammalia Itgal 33
  • 78.28 (n)
mouse
(Mus musculus)
Mammalia Itgal 33 16 34
  • 77.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ITGAL 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGAL 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGAL 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zmp:0000001082 33
  • 48.58 (n)
ITGAL 34
  • 30 (a)
OneToOne
Species where no ortholog for ITGAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAL Gene

ENSEMBL:
Gene Tree for ITGAL (if available)
TreeFam:
Gene Tree for ITGAL (if available)

Paralogs for ITGAL Gene

(3) SIMAP similar genes for ITGAL Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ITGAL: view

Variants for ITGAL Gene

Sequence variations from dbSNP and Humsavar for ITGAL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000015257 -- 30,479,537(+) GGAAA(A/T)GTTAG intron-variant
rs1000136272 -- 30,508,510(+) ACCCA(A/G)CCGAA intron-variant
rs1000167609 -- 30,483,628(+) AGTGT(C/G)AGGAC intron-variant
rs1000215271 -- 30,472,385(+) TCACT(C/T)TCTCC upstream-variant-2KB
rs1000217833 -- 30,519,160(+) AGAGG(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAL Gene

Variant ID Type Subtype PubMed ID
nsv1116127 CNV deletion 24896259
nsv1127486 CNV deletion 24896259
nsv1783 CNV deletion 18451855
nsv1784 CNV insertion 18451855

Variation tolerance for ITGAL Gene

Residual Variation Intolerance Score: 3.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAL Gene

Disorders for ITGAL Gene

MalaCards: The human disease database

(17) MalaCards diseases for ITGAL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
benign cephalic histiocytosis
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency 1
lichen planus
  • lichen ruber planus
rheumatoid arthritis
  • rheumatoid arthritis, progression of
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search ITGAL in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAL

Genetic Association Database (GAD)
ITGAL
Human Genome Epidemiology (HuGE) Navigator
ITGAL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAL
genes like me logo Genes that share disorders with ITGAL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAL Gene

Publications for ITGAL Gene

  1. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PMID: 10493852) Kallen J … Hommel U (Journal of molecular biology 1999) 3 4 22 25 60
  2. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PMID: 8097887) Cornwell RD … Hickstein DD (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 60
  3. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PMID: 8103515) Nueda A … Corbí AL (The Journal of biological chemistry 1993) 3 4 22 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms. (PMID: 16301335) Fagerholm SC … Gahmberg CG (The Journal of cell biology 2005) 3 4 60

Products for ITGAL Gene

  • Addgene plasmids for ITGAL

Sources for ITGAL Gene

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