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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGAL Gene

protein-coding GIFtS: 67
GCID: GC16P030483

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated...

(Previous symbol: CD11A)

Explore 138 diseases affiliated with
ITGAL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide)¹ ²		LFA1A² ⁵
CD11A¹ ² ³ ⁵		Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide²
LFA-1¹ ²		Integrin Alpha-L²
Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain² ³		Integrin Gene Promoter²
Leukocyte Function-Associated Molecule 1 Alpha Chain² ³		LFA-1 Alpha²
LFA-1A² ³		Lymphocyte Function-Associated Antigen 1²
CD11 Antigen-Like Family Member A² ³		CD11a Antigen³

External Ids:	HGNC: 6148¹	Entrez Gene: 3683²	Ensembl: ENSG00000005844⁷	OMIM: 153370⁵	UniProtKB: P20701³

Export aliases for ITGAL gene to outside databases

Previous GC identifers: GC16P029766 GC16P030972 GC16P030480 GC16P030520 GC16P030391 GC16P028046

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAL:

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha

chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the

integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central

role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion

molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of

immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody

dependent killing by granulocytes and monocytes

Gene Wiki entry for ITGAL (CD11a)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGAL gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAL promoter sequence

Search SABiosciences Chromatin IP Primers for ITGAL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p13.1-p11

ITGAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAL gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P030483: view genomic region (about GC identifiers)

Start:	30,483,979 bp from pter	End:	30,534,506 bp from pter
Size:	50,528 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701 (See protein sequence)

Recommended Name: Integrin alpha-L precursor

Size: 1170 amino acids; 128770 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2

Subcellular location: Membrane; Single-pass type I membrane protein

6/30 PDB 3D structures from and Proteopedia for ITGAL (see all 30):

1CQP (3D)

1DGQ (3D)

1IJ4 (3D)

1LFA (3D)

1MJN (3D)

1MQ8 (3D)

Secondary accessions: O43746 Q45H73 Q96HB1 Q9UBC8

Alternative splicing: 3 isoforms: P20701-1 P20701-2 P20701-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGAL: NX_P20701

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20701

ITGAL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001107852.1 NP_002200.2

ENSEMBL proteins:

ENSP00000349252 ENSP00000456521 ENSP00000350886 ENSP00000457785 ENSP00000454908

ENSP00000454342 ENSP00000456888 ENSP00000409377 ENSP00000461006 ENSP00000458739

ENSP00000408615

Reactome Protein details: P20701
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001772	immunological synapse	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	NAS	8103515
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	--	--

ITGAL for ontologies About GeneDecksing

ITGAL Antibody Products:

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Assay Products for ITGAL:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGAL for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P20701

ProtoNet protein and cluster: P20701

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of

immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody

dependent killing by granulocytes and monocytes

Genatlas biochemistry entry for ITGAL:

integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ITGAL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAL
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGAL (see all 15):
		hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*

		SwitchGear 3'UTR luciferase reporter plasmid: ITGAL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAL (see all 7) OriGene shRNA RFP: ITGAL OriGene siRNA: ITGAL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGAL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGAL
		Search LifeMap BioReagents cell lines for ITGAL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAL

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0046872	metal ion binding	IEA	--
GO:0046982	protein heterodimerization activity	--	--
GO:0050839	cell adhesion molecule binding	IPI	1448173

ITGAL for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for ITGAL:

Decreased number of cells in m

G0/1 arrest

Increased G1 DNA content

Increased cell size

Animal Models:
Mouse knock-outs for ITGAL: Itgal^tm1Mak Itgal^tm1Hlz Itgal^tm1Wpfl Itgal^tm1Bll
5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Itgal):

cellular

hematopoietic system

homeostasis/metabolism

immune system

tumorigenesis

ITGAL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Focal Adhesion

	Focal Adhesion	1.00			HGF Pathway	0.24
	Integrin-mediated cell adhesion	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ITGAL

	Immune response Role of integrins in NK cells cytotoxicity
	Cell adhesion Integrin inside-out signaling

5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAL (see all 35)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

3 GeneGo (Thomson Reuters) Pathways for ITGAL

	Cell adhesion Integrin inside-out signaling
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response Role of integrins in NK cells cytotoxicity

4 BioSystems Pathways for ITGAL

	Integrin-mediated cell adhesion
	Focal Adhesion
	Paxillin-dependent events mediated by a4b1
	CXCR3-mediated signaling events

5/7 Reactome Pathways for ITGAL (see all 7)

	Hemostasis
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Signal Transduction
	Adaptive Immune System

5/8 Kegg Pathways (Kegg details for ITGAL) (see all 8):

	Cell adhesion molecules (CAMs)
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Malaria

ITGAL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGAL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/58 Interacting proteins for ITGAL (P20701^{2, 3} ENSP00000349252⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRC	P08575²^,³, ENSP00000356346⁴	MINT-8213340 MINT-8213325 I2D: score=4 STRING: ENSP00000356346
RANBP9	Q96S59²^,³, ENSP00000011619⁴	MINT-50056 MINT-50070 I2D: score=3 STRING: ENSP00000011619
ICAM1	P05362³, ENSP00000264832⁴	I2D: score=5 STRING: ENSP00000264832
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=4 STRING: ENSP00000303242
CD82	P27701³, ENSP00000227155⁴	I2D: score=1 STRING: ENSP00000227155

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP	2477710
GO:0006928	cellular component movement	TAS	10477596
GO:0006954	inflammatory response	NAS	8103515
GO:0007155	cell adhesion	NAS	8103515
GO:0007157	heterophilic cell-cell adhesion	IMP	2477710

ITGAL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGAL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGAL

8 DrugBank Compounds for ITGAL About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Efalizumab	anti alphaL integrin (see all 4)	214745-43-4	target	antibody	17053736 11752352 19170413
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine	--	--	target	--	17139284 17016423
LFA703	--	--	target	--	17139284 17016423
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline	--	--	target	--	10592235
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile	--	--	target	--	10592235
Antithymocyte globulin	rabbit ATG (see all 3)	--	target	--	12586600
Lovastatin	6 alpha-Methylcompactin (see all 4)	75330-75-5	target	other/unknown	10493852
(S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE	--	--	target	--	--

10/96 Novoseek chemical compound relationships for ITGAL gene (see all 96) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
efalizumab	78.4	30	17167274 (2), 17587888 (2), 14627785 (1), 18341848 (1) (see all 21)
lfa703	70.8	3	15161667 (1), 15618295 (1)
slex	66.6	25	12845988 (2), 16689823 (1), 7541055 (1), 7487990 (1) (see all 14)
celgosivir	61.6	1	7780199 (1)
nkh 1	52.3	2	1905985 (1), 10541572 (1)
slea	52	1	9430509 (1)
cytochalasin b	48.3	8	18069239 (1), 9083889 (1), 2246503 (1), 10672935 (1) (see all 5)
phorbol	42.5	5	9765268 (2), 9735343 (1), 10531396 (1), 10634414 (1)
cuprophan	40.2	1	8770974 (1)
fmlp	38.6	5	1680065 (2), 8707129 (1), 12198042 (1), 10464825 (1)

Search CenterWatch for drugs/clinical trials and news about ITGAL / ITAL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGAL gene (2 alternative transcripts):

NM_001114380.1 NM_002209.2

Unigene Cluster for ITGAL:

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Hs.174103 [show with all ESTs]

Unigene Representative Sequence: NM_002209

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000356798(uc010veu.1) ENST00000562652 ENST00000569570 ENST00000358164(uc002dyi.4 uc002dyj.4 uc010vev.2)

ENST00000568926 ENST00000565864 ENST00000562857 ENST00000565348 ENST00000564118

ENST00000433423 ENST00000569725 ENST00000566149 ENST00000568012 ENST00000564935

ENST00000568987 ENST00000563615 ENST00000562020 ENST00000566267

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		hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*

		SwitchGear 3'UTR luciferase reporter plasmid: ITGAL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAL

Additional cDNA sequence:

AK298674.1 AK303190.1 AK314246.1 BC008777.2 Y00796.1

16 DOTS entries:

DT.455112 DT.99976275 DT.100684944 DT.120672226 DT.120672197 DT.40113484 DT.86855467 DT.86859420

DT.91659930 DT.101967087 DT.120672194 DT.91742949 DT.95184191 DT.92057784 DT.95184188 DT.95329677

24/121 AceView cDNA sequences (see all 121):

BM819802 CF142739 AW576571 AI350394 AX794818 AW505283 CA430398 AX794819

BC008777 BX114703 AW502651 BM768725 BM853879 AW502592 AX794817 BU430141

CF135698 AX794821 BU678102 BX457402 CA309449 AW137744 Y00796 BM145532

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·
SP1:											-		-				-
SP2:											-		-				-								-		-		-		-
SP3:
SP4:											-		-				-		-		-		-
SP5:																	-

ExUns:	16b	^	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32
SP1:	-
SP2:	-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ITGAL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTATCCA

About this image
See ITGAL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGAL

SOURCE GeneReport for Unigene cluster: Hs.174103

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701

Tissue specificity: Leukocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGAL:

Extracellular Matrix & Adhesion Molecules in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGAL gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ITGAL⁶ -- (see all 3)	--	38(a) 32(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343516.1(235252-250865) GL343516.1(363337-389505)
zebrafish (Danio rerio)	Actinopterygii	CABZ01043370.2⁶	--	30(a)	1 ↔ 1	1(60006661-60019406)
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ scb⁶ (see all 3)	scab (see all 3)	17(a) 16(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11136290-11146003)

ENSEMBL Gene Tree for ITGAL (if available)
TreeFam Gene Tree for ITGAL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGAL gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA2²

ITGA5² ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGA9² ITGA4²

ITGA10²

3 SIMAP similar genes for ITGAL using alignment to 9 protein entries: ITAL_HUMAN (see all proteins):

ITGAM ITGAD ITGAX

ITGAL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11574945^1,2	C,F,	--	28072702(+)	`ACAACA/GTAGGA`	1	--	ds500¹		7		NA NS WA	348
rs34854709^1,2	C	--	28074125(-)	`GTCTC-/AAAT AAATA`	1	--	us2k¹		1		NA	2
rs35121851^1,2		--	28074882(-)	`CACGCA/CGCTAA`	1	--	us2k¹		0	--	--	--	--
rs12446170^1,2	H	--	30481996(+)	`gagccA/Cccatg`	2	--	us2k¹		4		NS EA	418
rs140554870^1,2		--	30482203(+)	`AGTTCC/TAGCTA`	2	--	us2k¹		0	--	--	--	--
rs185687914^1,2		--	30482216(+)	`CAGGAC/TGCTGA`	2	--	us2k¹		0	--	--	--	--
rs188117124^1,2		--	30482244(+)	`AGCCCG/TTGAGG`	2	--	us2k¹		0	--	--	--	--
rs113303075^1,2	C,	--	30482393(+)	`GCCAGC/AAATGT`	2	--	us2k¹		2		NA	122
rs11150589^1,2	C,F,A,H,	--	30482494(+)	`CACTGC/TGGTTT`	2	--	us2k¹ tfbs³		20		NS EA NA WA	2344
rs12598978^1,2	C,F,A,H,	--	30482540(+)	`TATCAG/TTTCAT`	2	--	us2k¹		22		NS EA NA WA	2582

HapMap Linkage Disequilibrium report for ITGAL (30483979 - 30534506 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ITGAL: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGAL for disorders           About GeneDecksing

OMIM gene information: 153370    OMIM disorders: --

20/138 diseases for ITGAL (see all 138):    About MalaCards

graft versus host disease immune-complex glomerulonephritis lymph node cancer human t-cell leukemia virus type 1

hypersensitivity reaction type ii disease lichen planus cutaneous necrotizing vasculitis otitis media

mycosis fungoides venous insufficiency oral lichen planus myocardial infarction

guttate psoriasis lichen sclerosus coronary heart disease arteriosclerosis obliterans

membranoproliferative glomerulonephritis inflammatory bowel disease severe combined immunodeficiency sialadenitis

5 diseases from the University of Copenhagen DISEASES database for ITGAL:

Leukocyte adhesion deficiency Psoriasis Leukemia Lymphoma

Lung disease

10/88 Novoseek disease relationships for ITGAL gene (see all 88) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis	58.1	21	1401271 (1), 14627785 (1), 11758117 (1), 17596165 (1) (see all 15)
inflammation	52.1	46	11698049 (2), 10614768 (1), 10493852 (1), 11144049 (1) (see all 31)
necrosis	49.8	35	8656013 (2), 8094958 (2), 10198263 (2), 8394087 (1) (see all 25)
leukemia t-cell	34.5	5	7678112 (1), 7525481 (1), 7530239 (1), 11321434 (1)
lichen planus	33.6	6	8784900 (3), 1348286 (1), 17034521 (1)
tumors	30.6	74	9162263 (3), 10087180 (3), 1562732 (3), 8656013 (2) (see all 46)
immunodeficiency	30.5	23	12921757 (2), 11134324 (2), 7847878 (1), 8656013 (1) (see all 18)
skin diseases	29.6	3	11758117 (1), 7616000 (1), 1607407 (1)
autoimmunity	28.7	8	12163700 (3), 1671565 (1), 11130783 (1)
mycosis fungoides	28.7	2	7539248 (1), 8537552 (1)

Genetic Association Database (GAD): ITGAL
Human Genome Epidemiology (HuGE) Navigator: ITGAL (7 documents)

Export disorders for ITGAL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGAL gene, integrated from 9 sources (see all 1084):
(articles sorted by number of sources associating them with ITGAL)

Utopia: connect your pdf to the dynamic
world of online information

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PubMed id 10493852)^{1, 2, 7, 9} Kallen J.... Hommel U. (1999)
Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PubMed id 8097887)^{1, 2, 9} Cornwell R.D.... Hickstein D.D. (1993)
Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PubMed id 8103515)^{1, 2, 9} Nueda A.... Corbi A.L. (1993)
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)^{1, 4, 9} Hellmig S....Schreiber S. (2005)
Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. (PubMed id 8099450)^{1, 2, 9} Shelley C.S.... Arnaout M.A. (1993)
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. (PubMed id 12526797)^{1, 2} Shimaoka M....Springer T.A. (2003)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)
The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. (PubMed id 8805579)^{1, 2} Qu A. and Leahy D.J. (1996)
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. (PubMed id 7479767)^{1, 2} Qu A. and Leahy D.J. (1995)
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. (PubMed id 2537322)^{1, 2} Larson R.S.... Springer T. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3683	HGNC: 6148	AceView: ITGAL	Ensembl:ENSG00000005844	euGenes: HUgn3683
ECgene: ITGAL	Kegg: 3683	H-InvDB: ITGAL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGAL	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGAL	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/itgal/

Intellectual Property for ITGAL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGAL gene:
Search GeneIP for patents involving ITGAL

Licensable Technologies for ITGAL gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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