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ITGAL Gene

protein-coding   GIFtS: 70
GCID: GC16P030483

Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated...


(Previous symbol: CD11A)
  See ITGAL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated
Antigen 1; Alpha Polypeptide)1 2
     LFA-12
CD11A1 2 3 5     Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha
Polypeptide2
Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain2 3     Integrin Alpha-L2
Leukocyte Function-Associated Molecule 1 Alpha Chain2 3     Integrin Gene Promoter2
LFA-1A2 3     LFA-1 Alpha2
CD11 Antigen-Like Family Member A2 3     Lymphocyte Function-Associated Antigen 12
LFA1A2 5     CD11a Antigen3

External Ids:    HGNC: 61481   Entrez Gene: 36832   Ensembl: ENSG000000058447   OMIM: 1533705   UniProtKB: P207013   

Export aliases for ITGAL gene to outside databases

Previous GC identifers: GC16P029766 GC16P030972 GC16P030480 GC16P030520 GC16P030391 GC16P028046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGAL Gene:
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an
alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to
form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1
plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3
(intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGAL Gene:
ITGAL (integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)) is a protein-coding gene. Diseases associated with ITGAL include cutaneous necrotizing vasculitis, and benign cephalic histiocytosis. GO annotations related to this gene include cell adhesion molecule binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of
immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and
antibody dependent killing by granulocytes and monocytes

Gene Wiki entry for ITGAL (CD11a) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGAL gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAL promoter sequence
   Search Chromatin IP Primers for ITGAL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p13.1-p11

ITGAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030483:  view genomic region     (about GC identifiers)

Start:
30,483,979 bp from pter      End:
30,534,506 bp from pter
Size:
50,528 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701 (See protein sequence)
Recommended Name: Integrin alpha-L precursor  
Size: 1170 amino acids; 128770 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2
Selected PDB 3D structures from and Proteopedia for ITGAL (see all 32):
1CQP (3D)        1DGQ (3D)        1IJ4 (3D)        1LFA (3D)        1MJN (3D)        1MQ8 (3D)    
Secondary accessions: O43746 Q45H73 Q96HB1 Q9UBC8
Alternative splicing: 3 isoforms:  P20701-1   P20701-2   P20701-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGAL: NX_P20701

Explore proteomics data for ITGAL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93, Lys321, Lys371, Lys416, Lys776, Lys831, Lys836, Lys950
  • Glycosylation2 at Asn65, Asn89, Asn188, Asn649, Asn670, Asn726, Asn730, Asn862, Asn885, Asn897,
                                 Asn1060, Asn1071
  • Modification sites at PhosphoSitePlus

  • See ITGAL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107852.1  NP_002200.2  

    ENSEMBL proteins: 
     ENSP00000349252   ENSP00000456521   ENSP00000350886   ENSP00000457785   ENSP00000454908  
     ENSP00000454342   ENSP00000456888   ENSP00000409377   ENSP00000461006   ENSP00000458739  
     ENSP00000408615  
    Reactome Protein details: P20701

    ITGAL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGAL (Integrin alpha L beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAL
    OriGene Protein Over-expression Lysate for ITGAL
    OriGene MassSpec for ITGAL
    OriGene Custom Protein Services for ITGAL
    GenScript Custom Purified and Recombinant Proteins Services for ITGAL
    Novus Biologicals ITGAL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGAL 

    ITGAL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ITGAL (Integrin alpha L/CD11a)
    OriGene Antibodies for ITGAL
    OriGene Custom Antibody Services for ITGAL
    Novus Biologicals ITGAL Antibodies
    Abcam antibodies for ITGAL (P20701, P05107)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGAL
    LSBio Antibodies in human, mouse, rat for ITGAL

    ITGAL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAL
    R&D Systems Proteome Profiler Antibody Arrays for ITGAL (Integrin alpha L/CD11a)
    GenScript Custom Assay Services for ITGAL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGAL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    Selected InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P20701

    ProtoNet protein and cluster: P20701

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGAL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAL_HUMAN, P20701
    Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of
    immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and
    antibody dependent killing by granulocytes and monocytes

         Genatlas biochemistry entry for ITGAL:
    integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11544294
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0046982protein heterodimerization activity IEA--
    GO:0050839cell adhesion molecule binding IPI1448173
         
    Find genes that share ontologies with ITGAL           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ITGAL:
     Decreased number of cells in m  G0/1 arrest  Increased G1 DNA content  Increased cell size 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Itgal):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    Find genes that share phenotypes with ITGAL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ITGAL: Itgaltm1Mak Itgaltm1Hlz Itgaltm1Wpfl Itgaltm1Bll

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGAL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGAL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAL

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ITGAL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGAL (see all 15):
    hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidITGAL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGAL
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAL

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAL (see all 11)
    OriGene ORF clones in mouse, rat for ITGAL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
    Sino Biological Human cDNA Clone for ITGAL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL
    Addgene plasmids for ITGAL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAL
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITAL_HUMAN, P20701: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex NAS8103515
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----

    Find genes that share ontologies with ITGAL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGAL About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with ITGAL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGAL (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 GeneGo (Thomson Reuters) Pathways for ITGAL
        Cell adhesion Integrin inside-out signaling
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response Role of integrins in NK cells cytotoxicity

    4 BioSystems Pathways for ITGAL
        Focal Adhesion
    Integrin-mediated cell adhesion
    CXCR3-mediated signaling events
    Paxillin-dependent events mediated by a4b1


    3 Reactome Pathways for ITGAL
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Cell surface interactions at the vascular wall


    Selected Kegg Pathways  (Kegg details for ITGAL) (see all 11):
        Rap1 signaling pathway
    Cell adhesion molecules (CAMs)
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAL: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGAL (P207011, 2, 3 ENSP000003492524) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRCP085751, 2, 3, ENSP000003563464EBI-961214,EBI-1341 MINT-8213340 MINT-8213325 I2D: score=4 STRING: ENSP00000356346
    RANBP9Q96S592, 3, ENSP000000116194MINT-50056 MINT-50070 I2D: score=3 STRING: ENSP00000011619
    ENSG00000206379O759553I2D: score=1 
    ENSG00000206480O759553I2D: score=1 
    ENSG00000230143O759553I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP2477710
    GO:0006928cellular component movement TAS10477596
    GO:0006954inflammatory response NAS8103515
    GO:0007155cell adhesion NAS8103515
    GO:0007157heterophilic cell-cell adhesion IMP2477710

    Find genes that share ontologies with ITGAL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGAL (ITAL)

    8 DrugBank Compounds for ITGAL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Efalizumabanti alphaL integrin (see all 4)214745-43-4targetantibody17053736 11752352 19170413
    1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine-- --target--17139284 17016423
    LFA703-- --target--17139284 17016423
    3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline-- --target--10592235
    7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile-- --target--10592235
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600
    Lovastatin6 alpha-Methylcompactin (see all 4)75330-75-5targetother/unknown10493852
    (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE-- --target----

    Selected Novoseek inferred chemical compound relationships for ITGAL gene (see all 96)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    efalizumab 78.4 30 17167274 (2), 17587888 (2), 14627785 (1), 18341848 (1) (see all 21)
    lfa703 70.8 3 15161667 (1), 15618295 (1)
    slex 66.6 25 12845988 (2), 16689823 (1), 7541055 (1), 7487990 (1) (see all 14)
    celgosivir 61.6 1 7780199 (1)
    nkh 1 52.3 2 1905985 (1), 10541572 (1)
    slea 52 1 9430509 (1)
    cytochalasin b 48.3 8 18069239 (1), 9083889 (1), 2246503 (1), 10672935 (1) (see all 5)
    phorbol 42.5 5 9765268 (2), 9735343 (1), 10531396 (1), 10634414 (1)
    cuprophan 40.2 1 8770974 (1)
    fmlp 38.6 5 1680065 (2), 8707129 (1), 12198042 (1), 10464825 (1)



    Find genes that share compounds with ITGAL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGAL gene (2 alternative transcripts): 
    NM_001114380.1  NM_002209.2  

    Unigene Cluster for ITGAL:

    Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
    Hs.174103  [show with all ESTs]
    Unigene Representative Sequence: NM_002209
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000356798(uc010veu.1) ENST00000562652 ENST00000569570 ENST00000358164(uc002dyi.4 uc002dyj.4 uc010vev.2)
    ENST00000568926 ENST00000565864 ENST00000562857 ENST00000565348 ENST00000564118
    ENST00000433423 ENST00000569725 ENST00000566149 ENST00000568012 ENST00000564935
    ENST00000568987 ENST00000563615 ENST00000562020 ENST00000566267
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGAL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGAL (see all 15):
    hsa-miR-485-5p hsa-miR-4324 hsa-miR-1321 hsa-miR-130a* hsa-miR-1236 hsa-miR-23c hsa-miR-3138 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidITGAL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGAL
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAL
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAL (see all 11)
    OriGene ORF clones in mouse, rat for ITGAL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGAL (NM_002209)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAL
    Addgene plasmids for ITGAL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAL
      QuantiTect SYBR Green Assays in human, mouse, rat ITGAL
      QuantiFast Probe-based Assays in human, mouse, rat ITGAL

    Additional mRNA sequence: 

    AK298674.1 AK303190.1 AK314246.1 BC008777.2 Y00796.1 

    16 DOTS entries:

    DT.455112  DT.99976275  DT.100684944  DT.120672226  DT.120672197  DT.40113484  DT.86855467  DT.86859420 
    DT.91659930  DT.101967087  DT.120672194  DT.91742949  DT.95184191  DT.92057784  DT.95184188  DT.95329677 

    Selected AceView cDNA sequences (see all 121):

    CA430398 CF142739 BM853879 AW502651 AX794819 BM768725 AX794818 AW502592 
    AW505283 BM819802 AI350394 AW576571 BX114703 BC008777 CA426308 AW500465 
    BI769098 AW500768 BX953711 AA215666 AX794814 F30979 NM_002209 Y00796 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                -     -           -                                                                                                         
    SP2:                                -     -           -                       -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                -     -           -     -     -     -                                                                                       
    SP5:                                                  -                                                                                                         

    ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:  -                                                                                                               
    SP2:  -                                                                                                               
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ITGAL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ITGAL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATCCA
    ITGAL Expression
    About this image


    ITGAL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Adipose (Muscoskeletal System)
             Stromal Cells Subcutaneous White Adipose
     
     Spleen (Hematopoietic System)
    ITGAL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGAL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.174103

    UniProtKB/Swiss-Prot: ITAL_HUMAN, P20701
    Tissue specificity: Leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGAL: 
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              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGAL gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgal1 , 5 integrin alpha L1, 5 77.86(n)1
    73.19(a)1
      7 (69.44 cM)5
    164081  NM_001253872.11  NP_001240801.11 
     1272962605 
    lizard
    (Anolis carolinensis)
    Reptilia ITGAL6
    integrin, alpha L (antigen CD11A (p180), lymphocyt...
    41(a)
    1 ↔ 1
    GL343516.1(235225-282822)
    zebrafish
    (Danio rerio)
    Actinopterygii zmp:00000010821 zmp:0000001082 48.58(n)
    36.81(a)
      557935  XM_005171064.1  XP_005171121.1 


    ENSEMBL Gene Tree for ITGAL (if available)
    TreeFam Gene Tree for ITGAL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGAL gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGA92  ITGA42  
    ITGA102  
    3 SIMAP similar genes for ITGAL using alignment to 9 protein entries:     ITAL_HUMAN (see all proteins):
    ITGAM    ITGAD    ITGAX

    Find genes that share paralogs with ITGAL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGAL (see all 982)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124461701,2
    H--30481996(+) gagccA/Cccatg 2 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs3677807761,2
    C--30482090(+) GAGGCA/GGCAAA 2 -- us2k10--------
    rs1405548701,2
    --30482203(+) AGTTCC/TAGCTA 2 -- us2k10--------
    rs1856879141,2
    --30482216(+) CAGGAC/TGCTGA 2 -- us2k10--------
    rs1881171241,2
    --30482244(+) AGCCCG/TTGAGG 2 -- us2k10--------
    rs1133030751,2
    C,F--30482393(+) GCCAGC/AAATGT 2 -- us2k12Minor allele frequency- A:0.06NA 122
    rs111505891,2
    C,F,A,H--30482494(+) cactgC/Tggttt 2 -- us2k1 tfbs320Minor allele frequency- T:0.45NS EA NA WA 2344
    rs125989781,2
    C,F,A,H--30482540(+) tatcaG/Tttcat 2 -- us2k122Minor allele frequency- T:0.45NS EA NA WA 2582
    rs1162161491,2
    C,F--30482564(+) ATTTAT/CATGTC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1810133171,2
    --30482771(+) TCAAGC/TAGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGAL (30483979 - 30534506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITGAL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1784CNV Insertion18451855
    nsv1783CNV Loss18451855
    nsv905726CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAL
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153370    OMIM disorders: --

    8 diseases for ITGAL:    
    About MalaCards
    cutaneous necrotizing vasculitis    benign cephalic histiocytosis    actinic prurigo    guttate psoriasis
    sialadenitis    pustulosis palmaris et plantaris    leukocyte adhesion deficiency    acute myeloid leukemia

    5 diseases from the University of Copenhagen DISEASES database for ITGAL:
    Leukocyte adhesion deficiency     Psoriasis     Leukemia     Lymphoma
    Lung disease

    Find genes that share disorders with ITGAL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGAL gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 58.1 21 1401271 (1), 14627785 (1), 11758117 (1), 17596165 (1) (see all 15)
    inflammation 52.1 46 11698049 (2), 10614768 (1), 10493852 (1), 11144049 (1) (see all 31)
    necrosis 49.8 35 8656013 (2), 8094958 (2), 10198263 (2), 8394087 (1) (see all 25)
    leukemia t-cell 34.5 5 7678112 (1), 7525481 (1), 7530239 (1), 11321434 (1)
    lichen planus 33.6 6 8784900 (3), 1348286 (1), 17034521 (1)
    tumors 30.6 74 9162263 (3), 10087180 (3), 1562732 (3), 8656013 (2) (see all 46)
    immunodeficiency 30.5 23 12921757 (2), 11134324 (2), 7847878 (1), 8656013 (1) (see all 18)
    skin diseases 29.6 3 11758117 (1), 7616000 (1), 1607407 (1)
    autoimmunity 28.7 8 12163700 (3), 1671565 (1), 11130783 (1)
    mycosis fungoides 28.7 2 7539248 (1), 8537552 (1)

    Genetic Association Database (GAD): ITGAL
    Human Genome Epidemiology (HuGE) Navigator: ITGAL (7 documents)

    Export disorders for ITGAL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGAL gene, integrated from 10 sources (see all 1093):
    (articles sorted by number of sources associating them with ITGAL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PubMed id 10493852)1, 2, 7, 9 Kallen J.... Hommel U. (J. Mol. Biol. 1999)
    2. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PubMed id 8097887)1, 2, 9 Cornwell R.D.... Hickstein D.D. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PubMed id 8103515)1, 2, 9 Nueda A.... Corbi A.L. (J. Biol. Chem. 1993)
    4. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PubMed id 15730520)1, 4, 9 Hellmig S....Schreiber S. (Tissue Antigens 2005)
    5. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. (PubMed id 8099450)1, 2, 9 Shelley C.S.... Arnaout M.A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. (PubMed id 12526797)1, 2 Shimaoka M....Springer T.A. (Cell 2003)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    9. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. (PubMed id 8805579)1, 2 Qu A. and Leahy D.J. (Structure 1996)
    10. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. (PubMed id 7479767)1, 2 Qu A. and Leahy D.J. (Proc. Natl. Acad. Sci. U.S.A. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3683 HGNC: 6148 AceView: ITGAL Ensembl:ENSG00000005844 euGenes: HUgn3683
    ECgene: ITGAL Kegg: 3683 H-InvDB: ITGAL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGAL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAL Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/itgal/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGAL gene:
    Search GeneIP for patents involving ITGAL

    Licensable Technologies for ITGAL gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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